﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Pfister, DG
   Cassileth, BR
   Deng, GE
   Yeung, KS
   Lee, JS
   Garrity, D
   Cronin, A
   Lee, N
   Kraus, D
   Shaha, AR
   Shah, J
   Vickers, AJ
AF Pfister, David G.
   Cassileth, Barrie R.
   Deng, Gary E.
   Yeung, K. Simon
   Lee, Jennifer S.
   Garrity, Donald
   Cronin, Angel
   Lee, Nancy
   Kraus, Dennis
   Shaha, Ashok R.
   Shah, Jatin
   Vickers, Andrew J.
TI Acupuncture for Pain and Dysfunction After Neck Dissection: Results of a
   Randomized Controlled Trial
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID QUALITY-OF-LIFE; SPINAL ACCESSORY NERVE; INTENSITY-MODULATED
   RADIOTHERAPY; STAGE NASOPHARYNGEAL CARCINOMA; CLINICAL-TRIAL;
   POSTIRRADIATION XEROSTOMIA; SHOULDER; CANCER; HEAD; SCALES
AB Purpose
   To determine whether acupuncture reduces pain and dysfunction in patients with cancer with a history of neck dissection. The secondary objective is to determine whether acupuncture relieves dry mouth in this population.
   Patients and Methods
   Patients at a tertiary cancer center with chronic pain or dysfunction attributed to neck dissection were randomly assigned to weekly acupuncture versus usual care (eg, physical therapy, analgesia, and/or anti-inflammatory drugs, per patient preference or physician recommendation) for 4 weeks. The Constant-Murley score, a composite measure of pain, function, and activities of daily living, was the primary outcome measure. Xerostomia, a secondary end point, was assessed using the Xerostomia Inventory.
   Results
   Fifty-eight evaluable patients were accrued and randomly assigned from 2004 to 2007 (28 and 30 patients on acupuncture and control arms, respectively). Constant-Murley scores improved more in the acupuncture group (adjusted difference between groups = 11.2; 95% CI, 3.0 to 19.3; P = .008). Acupuncture produced greater improvement in reported xerostomia (adjusted difference in Xerostomia Inventory = -5.8; 95% CI, -0.9 to -10.7; P = .02).
   Conclusion
   Significant reductions in pain, dysfunction, and xerostomia were observed in patients receiving acupuncture versus usual care. Although further study is needed, these data support the potential role of acupuncture in addressing post-neck dissection pain and dysfunction, as well as xerostomia.
C1 Mem Sloan Kettering Canc Ctr, Dept Med, Sect Head & Neck Oncol, New York, NY 10021 USA.
   Mem Sloan Kettering Canc Ctr, Dept Med, Sect Integrat Med, New York, NY 10021 USA.
   Mem Sloan Kettering Canc Ctr, Dept Epidemiol Biostat, New York, NY 10021 USA.
   Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA.
   Mem Sloan Kettering Canc Ctr, Dept Surg, Head & Neck Surg Serv, New York, NY 10021 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering
   Cancer Center; Memorial Sloan Kettering Cancer Center
RP Pfister, DG (corresponding author), Mem Hosp, 1275 York Ave,Box 188, New York, NY 10065 USA.
EM pfisterd@mskcc.org
OI Vickers, Anew/0000-0003-1525-6503; Shah, Jatin/0000-0002-6444-6592;
   Yeung, Kwokwai/0000-0002-4930-4895
FU National Institutes of Health (Bethesda, MD) [CA098792]
FX Supported by Grant No. CA098792 from the National Institutes of Health
   (Bethesda, MD).
CR Andersen SW, 1997, ORAL ONCOL, V33, P146, DOI 10.1016/S0964-1955(96)00058-9
   [Anonymous], HEAD NECK
   Bolton JE, 1998, J MANIP PHYSIOL THER, V21, P1
   Breivik EK, 2000, CLIN J PAIN, V16, P22, DOI 10.1097/00002508-200003000-00005
   Brizel DM, 2000, J CLIN ONCOL, V18, P3339, DOI 10.1200/JCO.2000.18.19.3339
   Cappiello J, 2005, LARYNGOSCOPE, V115, P259, DOI 10.1097/01.mlg.0000154729.31281.da
   Ceccherelli F, 2001, ACUPUNCTURE ELECTRO, V26, P229, DOI 10.3727/036012901816355938
   Chambers MS, 2007, INT J RADIAT ONCOL, V68, P1102, DOI 10.1016/j.ijrobp.2007.01.019
   Cheng PT, 2000, ANN OTO RHINOL LARYN, V109, P761, DOI 10.1177/000348940010900811
   CONSTANT CR, 1987, CLIN ORTHOP RELAT R, P160
   Deng G, 2008, BMC COMPLEM ALTERN M, V8, DOI 10.1186/1472-6882-8-37
   Erisen L, 2004, HEAD NECK-J SCI SPEC, V26, P967, DOI 10.1002/hed.20095
   Ernst E, 1998, BRIT DENT J, V184, P443, DOI 10.1038/sj.bdj.4809654
   FRISON L, 1992, STAT MED, V11, P1685, DOI 10.1002/sim.4780111304
   FRYDHOLM M, 1999, J PALLIAT CARE, V15, P20
   Inoue H, 2006, ARCH OTOLARYNGOL, V132, P662, DOI 10.1001/archotol.132.6.662
   Irnich D, 2002, PAIN, V99, P83, DOI 10.1016/S0304-3959(02)00062-3
   Irnich D, 2001, BMJ-BRIT MED J, V322, P1574, DOI 10.1136/bmj.322.7302.1574
   Jemal A, 2009, CA-CANCER J CLIN, V59, P225, DOI 10.3322/caac.20006
   JOHNSON JT, 1993, NEW ENGL J MED, V329, P390, DOI 10.1056/NEJM199308053290603
   Johnstone PAS, 2002, CANCER, V94, P1151, DOI 10.1002/cncr.10348
   Kam MKM, 2007, J CLIN ONCOL, V25, P4873, DOI 10.1200/JCO.2007.11.5501
   Kleinhenz J, 1999, PAIN, V83, P235, DOI 10.1016/S0304-3959(99)00107-4
   KRAUSE HR, 1992, INT J ORAL MAX SURG, V21, P276
   Kuntz AL, 1999, LARYNGOSCOPE, V109, P1334, DOI 10.1097/00005537-199908000-00030
   Laverick S, 2004, ARCH OTOLARYNGOL, V130, P149, DOI 10.1001/archotol.130.2.149
   LEIPZIG B, 1983, AM J SURG, V146, P526, DOI 10.1016/0002-9610(83)90246-5
   McNeely ML, 2008, CANCER, V113, P214, DOI 10.1002/cncr.23536
   Melchart D, 1999, CEPHALALGIA, V19, P779, DOI 10.1046/j.1468-2982.1999.1909779.x
   Nutting C, 2009, J CLIN ONCOL, V27
   O'Connor DA, 1999, ARTHROSCOPY, V15, P836, DOI 10.1053/ar.1999.v15.015083
   Paice JA, 1997, CANCER NURS, V20, P88, DOI 10.1097/00002820-199704000-00002
   PEETS JM, 1978, NATURE, V273, P675, DOI 10.1038/273675a0
   POMERANZ B, 1976, LIFE SCI, V19, P1757, DOI 10.1016/0024-3205(76)90084-9
   Pow EHN, 2006, INT J RADIAT ONCOL, V66, P981, DOI 10.1016/j.ijrobp.2006.06.013
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Robbins KT, 2008, ARCH OTOLARYNGOL, V134, P536, DOI 10.1001/archotol.134.5.536
   SCHULZ KF, 1995, JAMA-J AM MED ASSOC, V273, P408, DOI 10.1001/jama.273.5.408
   SHONE GR, 1991, J LARYNGOL OTOL, V105, P760, DOI 10.1017/S0022215100117232
   Skutek M, 2000, ARCH ORTHOP TRAUM SU, V120, P432, DOI 10.1007/s004020000133
   SOBOL S, 1985, AM J SURG, V150, P503, DOI 10.1016/0002-9610(85)90164-3
   STEEDMAN SM, 1992, CLIN J PAIN, V8, P204, DOI 10.1097/00002508-199209000-00004
   *STRICTA, STAND REP CLIN TRIAL
   Sun K. O., 2001, Hong Kong Medical Journal, V7, P381
   Terrell JE, 2000, LARYNGOSCOPE, V110, P620, DOI 10.1097/00005537-200004000-00016
   Thomson WM, 1999, COMMUNITY DENT HLTH, V16, P12
   van Wilgen CP, 2003, BRIT J ORAL MAX SURG, V41, P7, DOI 10.1016/S0266-4356(02)00288-7
   Vickers A, 2001, BRIT MED J, V323, P1306, DOI 10.1136/bmj.323.7324.1306
   Witt Robert L, 2006, Ear Nose Throat J, V85, P540
NR 49
TC 127
Z9 138
U1 2
U2 19
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2010
VL 28
IS 15
BP 2565
EP 2570
DI 10.1200/JCO.2009.26.9860
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 598JO
UT WOS:000277832400012
PM 20406930
OA Bronze
DA 2026-01-16
ER

PT J
AU Cassileth, BR
   Keefe, FJ
AF Cassileth, Barrie R.
   Keefe, Francis J.
TI Integrative and Behavioral Approaches to the Treatment of Cancer-Related
   Neuropathic Pain
SO ONCOLOGIST
LA English
DT Article
DE Acupuncture; Pain; Cancer; Psychological stress; Behavioral medicine;
   Integrative medicine; Complementary therapies
ID ACUPUNCTURE; THERAPY
AB Integrative oncology is the synthesis of mainstream cancer care and evidence-based complementary therapies. Complementary strategies include massage therapies, acupuncture, fitness, and mind-body techniques, which take advantage of the reciprocal relationship between the mind and body. Neuropathic pain-and pain more generally-is part of a complex process involving the whole physical and psychosocial being, therefore requiring an integrative management approach. Several studies have demonstrated, for example, that social context plays an important role in the perception of pain and that a patient's coping strategies can influence the persistence of pain. In this article, we briefly describe research illustrating the promise of integrative approaches for the treatment of cancer-related neuropathic pain. The Oncologist 2010; 15(suppl 2): 19-23
C1 [Keefe, Francis J.] Duke Univ, Med Ctr, Duke Pain Prevent & Treatment Res Program, Durham, NC 27705 USA.
   [Cassileth, Barrie R.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
C3 Duke University; Memorial Sloan Kettering Cancer Center
RP Keefe, FJ (corresponding author), Duke Univ, Med Ctr, Duke Pain Prevent & Treatment Res Program, Suite 340,2200 Main St, Durham, NC 27705 USA.
EM keefe003@mc.duke.edu
FU NIH [R01 CA131148, R01 CA100771]
FX We thank Dr. Mark Jensen whose advice was invaluable in preparing the
   section on self-hypnosis. Preparation of this manuscript was supported,
   in part, by NIH Grants R01 CA131148 and R01 CA100771.
CR [Anonymous], DRUGS FDA
   [Anonymous], NCCN CLIN PRACT GUID
   Bardia A, 2006, J CLIN ONCOL, V24, P5457, DOI 10.1200/JCO.2006.08.3725
   Borud EK, 2009, MENOPAUSE, V16, P484, DOI 10.1097/gme.0b013e31818c02ad
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   Chan BL, 2007, NEW ENGL J MED, V357, P2206, DOI 10.1056/NEJMc071927
   Dawidson I, 1998, LIFE SCI, V63, P659, DOI 10.1016/S0024-3205(98)00317-8
   Deng G, 2008, BMC COMPLEM ALTERN M, V8, DOI 10.1186/1472-6882-8-37
   Ehde DM, 2004, REHABIL PSYCHOL, V49, P254, DOI 10.1037/0090-5550.49.3.254
   Jensen MP, 2009, INT J CLIN EXP HYP, V57, P239, DOI 10.1080/00207140902881007
   Jensen TS, 2009, CURR OPIN NEUROL, V22, P467, DOI 10.1097/WCO.0b013e3283311e13
   Kaptchuk TJ., 2000, The Web That Has No Weaver: Understanding Chinese Medicine, V2, P1
   Lake Alvin E 3rd, 2006, Curr Pain Headache Rep, V10, P4, DOI 10.1007/s11916-006-0002-6
   Langevin HM, 2006, J CELL PHYSIOL, V207, P767, DOI 10.1002/jcp.20623
   Pfister DG, 2008, J CLIN ONCOL, V26, P4701, DOI 10.1200/JCO.2008.17.3682
   Pollo A, 2009, PROG BRAIN RES, V175, P283, DOI 10.1016/S0079-6123(09)17520-9
   Santiago-Figueroa J, 2009, P R HEALTH SCI J, V28, P289
   Treede RD, 2008, NEUROLOGY, V70, P1630, DOI 10.1212/01.wnl.0000282763.29778.59
   *US C, 1990, FIN ACC CANC TREATM, P175
   Vickers Andrew J, 2005, BMC Palliat Care, V4, P5, DOI 10.1186/1472-684X-4-5
   Vickers Andrew J, 2006, BMC Anesthesiol, V6, P5, DOI 10.1186/1471-2253-6-5
   Zaza C, 2002, J PAIN SYMPTOM MANAG, V24, P526, DOI 10.1016/S0885-3924(02)00497-9
   Zhou YH, 2009, AM J CLIN ONCOL-CANC, V32, P319, DOI 10.1097/COC.0b013e318173a520
NR 23
TC 38
Z9 48
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1083-7159
EI 1549-490X
J9 ONCOLOGIST
JI Oncologist
PD MAY
PY 2010
VL 15
SU 2
BP 19
EP 23
DI 10.1634/theoncologist.2009-S504
PG 5
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 599NL
UT WOS:000277919900005
PM 20489193
DA 2026-01-16
ER

PT J
AU Paloni, EDMP
   Alves, FB
   Morais, AD
   Pereira, ML
   Bahmdouni, L
AF Paloni, E. D. M. P.
   Bonachela Alves, F.
   Morais, A. D.
   Pereira, M. L.
   Bahmdouni, L.
TI THE COST OF STRONG OPIOID TREATMENT OF ONCOLOGICAL PAIN IN THE BRAZILIAN
   PRIVATE HEALTH CARE SYSTEM
SO VALUE IN HEALTH
LA English
DT Meeting Abstract
C1 [Paloni, E. D. M. P.; Bonachela Alves, F.] ORIZON Companhia Brasileira Gestao Serv, Sao Paulo, Brazil.
   [Morais, A. D.; Pereira, M. L.; Bahmdouni, L.] Janssen Cilag Farmaceut, Sao Paulo, Brazil.
C3 Johnson & Johnson; Johnson & Johnson Brazil
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1098-3015
J9 VALUE HEALTH
JI Value Health
PD NOV
PY 2011
VL 14
IS 7
BP A444
EP A444
DI 10.1016/j.jval.2011.08.1159
PG 1
WC Economics; Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Business & Economics; Health Care Sciences & Services
GA 876KT
UT WOS:000299107101232
DA 2026-01-16
ER

PT J
AU Ding, YY
   Xu, F
   Wang, YF
   Han, LL
   Huang, SQ
   Zhao, S
   Ma, LL
   Zhang, TH
   Zhao, WJ
   Chen, XD
AF Ding, Yuan-yuan
   Xu, Feng
   Wang, Ya-feng
   Han, Lin-lin
   Huang, Shi-qian
   Zhao, Shuai
   Ma, Lu-lin
   Zhang, Tian-hao
   Zhao, Wen-jing
   Chen, Xiang-dong
TI Electroacupuncture alleviates postoperative pain through inhibiting
   neuroinflammation via stimulator of interferon genes/type-1 interferon
   pathway
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Article
DE Electroacupuncture; Inflammation; Pain; Primary sensory neurons;
   Stimulator of interferon genes; Type -1 interferon
ID INFLAMMATORY PAIN; NEUROPATHIC PAIN; RAT; INJURY; HYPERSENSITIVITY;
   ACTIVATION; MECHANISMS; LAPAROTOMY; ALLODYNIA; ANALGESIA
AB Objective: This work explores the impact of electroacupuncture (EA) on acute postoperative pain (APP) and the role of stimulator of interferon genes/type-1 interferon (STING/IFN-1) signaling pathway modulation in the analgesic effect of EA in APP rats. Methods: The APP rat model was initiated through abdominal surgery and the animals received two 30 min sessions of EA at bilateral ST36 (Zusanli) and SP6 (Sanyinjiao) acupoints. Mechanical, thermal and cold sensitivity tests were performed to measure the pain threshold, and electroencephalograms were recorded in the primary somatosensory cortex to identify the effects of EA treatment on APP. Western blotting and immunofluorescence were used to examine the expression and distribution of proteins in the STING/IFN-1 pathway as well as neuroinflammation. A STING inhibitor (C-176) was administered intrathecally to verify its role in EA.Results: APP rats displayed mechanical and thermal hypersensitivities compared to the control group (P < 0.05). APP significantly reduced the amplitude of 0, a and c oscillations compared to their baseline values (P < 0.05). Interestingly, expression levels of proteins in the STING/IFN-1 pathway were downregulated after inducing APP (P < 0.05). Further, APP increased pro-inflammatory factors, including interleukin-6, tumor necrosis factor-a and inducible nitric oxide synthase, and downregulated antiinflammatory factors, including interleukin-10 and arginase-1 (P < 0.05). EA effectively attenuated APP-induced painful hypersensitivities (P < 0.05) and restored the 0, a and c power in APP rats (P < 0.05). Meanwhile, EA distinctly activated the STING/IFN-1 pathway and mitigated the neuroinflammatory response (P < 0.05). Furthermore, STING/IFN-1 was predominantly expressed in isolectin-B4- or calcitonin-gene-related-peptide-labeled dorsal root ganglion neurons and superficial laminae of the spinal dorsal horn. Inhibition of the STING/IFN-1 pathway by intrathecal injection of C-176 weakened the analgesic and anti-inflammatory effects of EA on APP (P < 0.05). Conclusion: EA can generate robust analgesic and anti-inflammatory effects on APP, and these effects may be linked to activating the STING/IFN-1 pathway, suggesting that STING/IFN-1 may be a target for relieving APP. Please cite this article as: Ding YY, Xu F, Wang YF, Han LL, Huang SQ, Zhao S, Ma LL, Zhang TH, Zhao WJ, Chen XD. Electroacupuncture alleviates postoperative pain through inhibiting neuroinflammation via stimulator of interferon genes/type-1 interferon pathway. J Integr Med. 2023; 21(5): 496-508.(c) 2023 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. All rights reserved.
C1 [Ding, Yuan-yuan; Xu, Feng; Wang, Ya-feng; Han, Lin-lin; Huang, Shi-qian; Zhao, Shuai; Ma, Lu-lin; Zhang, Tian-hao; Zhao, Wen-jing; Chen, Xiang-dong] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430022, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Chen, XD (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430022, Hubei, Peoples R China.
EM xdchen@hust.edu.cn
RI ding, yuanyuan/ISA-9433-2023; HAN, Linlin/KVB-1879-2024; Zhang,
   Tianhao/IAQ-9078-2023; Xu, Feng/GXH-6922-2022; Chen,
   Xiangdong/KCX-7707-2024; 马, 璐琳/ITT-4028-2023
FU National Natural Science Foundation of China [82071251]; National Key
   Research and Development Program of China [2018YFC2001802]; Hubei
   Province Key Research and Development Program [2021BCA145]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 82071251) , National Key Research and Development
   Program of China (Grant No. 2018YFC2001802) and Hubei Province Key
   Research and Development Program (Grant No. 2021BCA145) .
CR Barr MS, 2013, J NEUROIMMUNE PHARM, V8, P535, DOI 10.1007/s11481-012-9383-y
   Basbaum AI, 2009, CELL, V139, P267, DOI 10.1016/j.cell.2009.09.028
   Beaulieu P, 2021, PAIN, V162, P2309, DOI 10.1097/j.pain.0000000000002294
   Cavanaugh DJ, 2009, P NATL ACAD SCI USA, V106, P9075, DOI 10.1073/pnas.0901507106
   Chai WX, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/2598975
   Chang XY, 2022, NEURAL REGEN RES, V17, P2526, DOI 10.4103/1673-5374.339003
   CHAPLAN SR, 1994, J NEUROSCI METH, V53, P55, DOI 10.1016/0165-0270(94)90144-9
   Charlet A, 2011, J PAIN, V12, P246, DOI 10.1016/j.jpain.2010.07.005
   Chen J., 2013, Neuroscience in the 21st Century: From Basic to Clinical, P965, DOI DOI 10.1007/978-1-4614-1997-6_32
   Cheng ZL, 2020, SIGNAL TRANSDUCT TAR, V5, DOI 10.1038/s41392-020-0198-7
   Dan Y., 2004, J Acupunct Tuina Sci, V2, P34, DOI [10.1007/BF02848398, DOI 10.1007/BF02848398]
   Deuis JR, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00284
   Dobbs N, 2015, CELL HOST MICROBE, V18, P157, DOI 10.1016/j.chom.2015.07.001
   Donnelly CR, 2021, NATURE, V591, P275, DOI 10.1038/s41586-020-03151-1
   Donnelly CR, 2020, TRENDS NEUROSCI, V43, P822, DOI 10.1016/j.tins.2020.07.008
   Fairbanks CA, 2003, ADV DRUG DELIVER REV, V55, P1007, DOI 10.1016/S0169-409X(03)00101-7
   Feng L, 2021, NEURAL PLAST, V2021, DOI 10.1155/2021/8537437
   Feng XM, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-225
   Gao YH, 2017, PURINERG SIGNAL, V13, P215, DOI 10.1007/s11302-016-9552-1
   Gao Y, 2020, BRAIN BEHAV IMMUN, V88, P482, DOI 10.1016/j.bbi.2020.04.019
   Gao YH, 2013, NEUROCHEM RES, V38, P1467, DOI 10.1007/s11064-013-1047-7
   Gu N, 2016, CELL REP, V16, P605, DOI 10.1016/j.celrep.2016.06.018
   Hajat Z, 2017, ANAESTHESIA, V72, P38, DOI 10.1111/anae.13739
   Han LL, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.728300
   HARGREAVES K, 1988, PAIN, V32, P77, DOI 10.1016/0304-3959(88)90026-7
   He Lan, 2012, Zhongguo Zhen Jiu, V32, P107
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hou PP, 2021, CELL MOL IMMUNOL, V18, P2358, DOI 10.1038/s41423-021-00758-w
   Hu L, 2019, P NATL ACAD SCI USA, V116, P1782, DOI 10.1073/pnas.1812499116
   Ji RR, 2018, ANESTHESIOLOGY, V129, P343, DOI 10.1097/ALN.0000000000002130
   Ji RR, 2016, SCIENCE, V354, P572, DOI 10.1126/science.aaf8924
   Jiang QY, 2016, ACUPUNCT MED, V34, P223, DOI 10.1136/acupmed-2015-010951
   Kalso E, 2013, BRIT J ANAESTH, V111, P9, DOI 10.1093/bja/aet211
   Kim JH, 2004, BRAIN RES, V998, P230, DOI 10.1016/j.brainres.2003.11.045
   LeBlanc BW, 2016, PAIN, V157, P2330, DOI 10.1097/j.pain.0000000000000652
   Lee SH, 2012, MOL MED REP, V6, P157, DOI 10.3892/mmr.2012.879
   Li WW, 2020, SCI TRANSL MED, V12, DOI 10.1126/scitranslmed.aay9013
   Li YY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235917
   Liao HY, 2021, AM J CHINESE MED, V49, P1417, DOI 10.1142/S0192415X2150066X
   Lin JG, 2002, PAIN, V99, P509, DOI 10.1016/S0304-3959(02)00261-0
   Liu CC, 2016, SCI REP-UK, V6, DOI 10.1038/srep34356
   Liu QY, 2021, PAIN THER, V10, P1755, DOI 10.1007/s40122-021-00283-8
   Liu SB, 2021, NATURE, V598, P641, DOI 10.1038/s41586-021-04001-4
   Lv ZT, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1899-6
   Malver LP, 2014, BRIT J CLIN PHARMACO, V77, P72, DOI 10.1111/bcp.12137
   Martin TJ, 2004, ANESTHESIOLOGY, V101, P191, DOI 10.1097/00000542-200407000-00030
   McCoy ES, 2013, NEURON, V78, P138, DOI 10.1016/j.neuron.2013.01.030
   Meng XZ, 2011, BRAIN RES, V1414, P58, DOI 10.1016/j.brainres.2011.08.004
   Niwa F, 2019, ISCIENCE, V22, P453, DOI 10.1016/j.isci.2019.11.013
   Norcini M, 2016, FRONT MOL NEUROSCI, V9, DOI 10.3389/fnmo1.2015.00100
   Peng XX, 2017, MOL PAIN, V13, DOI 10.1177/1744806917697007
   Sideris-Lampretsas G, 2022, SCIENCE, V376, P33, DOI 10.1126/science.abo5592
   Simis M, 2022, PAIN MED, V23, P955, DOI 10.1093/pm/pnab124
   Small C, 2020, BJS-BRIT J SURG, V107, pE70, DOI 10.1002/bjs.11477
   Sun J, 2022, J NEUROIMMUNE PHARM, V17, P453, DOI 10.1007/s11481-021-10031-6
   Tan LL, 2021, TRENDS NEUROSCI, V44, P629, DOI 10.1016/j.tins.2021.05.003
   Wang KY, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-24867-2
   Wang XM, 2021, J CLIN ANESTH, V68, DOI 10.1016/j.jclinane.2020.110071
   Wang YP, 2020, J NEUROINFLAMM, V17, DOI 10.1186/s12974-020-01991-2
   Xiang XN, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20133248
   Xing Guogang, 2003, Beijing Da Xue Xue Bao Yi Xue Ban, V35, P453
   Xu J, 2016, ANESTH ANALG, V122, P882, DOI 10.1213/ANE.0000000000001097
   Yang LY, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.955581
   Zhong SB, 2009, EVID-BASED COMPL ALT, V6, P51, DOI 10.1093/ecam/nem062
   Zhu HM, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00466
   Zhu YY, 2019, MOL CANCER, V18, DOI 10.1186/s12943-019-1087-y
NR 66
TC 9
Z9 12
U1 3
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD SEP
PY 2023
VL 21
IS 5
BP 496
EP 508
DI 10.1016/j.joim.2023.07.001
EA SEP 2023
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA U1IC4
UT WOS:001082399600001
PM 37517892
DA 2026-01-16
ER

PT J
AU Liou, KT
   Hung, TKW
   Meghani, SH
   Epstein, AS
   Li, QSS
   Romero, SAD
   Cohen, RB
   Mao, JJ
AF Liou, Kevin T.
   Hung, Tony K. W.
   Meghani, Salimah H.
   Epstein, Andrew S.
   Li, Q. Susan
   Romero, Sally A. D.
   Cohen, Roger B.
   Mao, Jun J.
TI What if Acupuncture Were Covered by Insurance for Pain Management? A
   Cross-Sectional Study of Cancer Patients at One Academic Center and 11
   Community Hospitals
SO PAIN MEDICINE
LA English
DT Article
DE Acupuncture; Pain; Cancer; Insurance; Disparities; Health Beliefs;
   Access
ID ALTERNATIVE MEDICINE USE; PERSISTENT OPIOID USE; PLANNED BEHAVIOR;
   BREAST-CANCER; COMPLEMENTARY; ATTITUDES; DISPARITIES; PREVALENCE;
   GUIDELINE; SURVIVORS
AB Objective. In response to the national opioid crisis, governmental and medical organizations have called for broader insurance coverage of acupuncture to improve access to nonpharmacologic pain therapies, especially in cancer populations, where undertreatment of pain is prevalent. We evaluated whether cancer patients would be willing to use insurance-covered acupuncture for pain. Design and Setting. We conducted a cross-sectional survey of cancer patients with pain at one academic center and 11 community hospitals. Methods. We used logistic regression models to examine factors associated with willingness to use insurance-covered acupuncture for pain. Results. Among 634 cancer patients, 304 (47.9%) reported willingness to use insurance-covered acupuncture for pain. In univariate analyses, patients were more likely to report willingness if they had severe pain (odds ratio [OR] = 1.59, 95% confidence interval [CI] = 1.03-2.45) but were less likely if they were nonwhite (OR = 0.59, 95% CI = 0.39-0.90) or had only received high school education or less (OR = 0.46, 95% CI = 0.32-0.65). After adjusting for attitudes and beliefs in multivariable analyses, willingness was no longer significantly associated with education (adjusted OR [aOR] = 0.78, 95% CI = 0.50-1.21) and was more negatively associated with nonwhite race (aOR = 0.49, 95% CI = 0.29-0.84). Conclusions. Approximately one in two cancer patients was willing to use insurance-covered acupuncture for pain. Willingness was influenced by patients' attitudes and beliefs, which are potentially modifiable through counseling and education. Further research on racial disparities is needed to close the gap in utilization as acupuncture is integrated into insurance plans in response to the opioid crisis.
C1 [Liou, Kevin T.; Li, Q. Susan; Romero, Sally A. D.; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, 1429 First Ave, New York, NY 10021 USA.
   [Hung, Tony K. W.] Olive View UCLA Med Ctr, Dept Hematol Oncol, 14445 Olive View Dr, Sylmar, CA 91342 USA.
   [Meghani, Salimah H.] Univ Penn, Sch Nursing, Dept Biobehav Hlth Sci, Philadelphia, PA 19104 USA.
   [Epstein, Andrew S.] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA.
   [Epstein, Andrew S.; Mao, Jun J.] Weill Cornell Med Coll, Dept Med, New York, NY USA.
   [Cohen, Roger B.] Univ Penn, Div Hematol Oncol, Perelman Sch Med, Philadelphia, PA 19104 USA.
C3 Memorial Sloan Kettering Cancer Center; University of California System;
   University of California Los Angeles; University of Pennsylvania;
   Memorial Sloan Kettering Cancer Center; Cornell University; Weill
   Cornell Medicine; University of Pennsylvania
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, 1429 First Ave, New York, NY 10021 USA.
EM maoj@mskcc.org
RI ; Hung, Tony/LLK-9898-2024
OI Meghani, Salimah/0000-0002-5866-8279; 
FU National Cancer Institute [2P30CA016520-40, 3P30CA008748-50]; Byrne
   Fund; Translational Research and Integrative Medicine Fund at Memorial
   Sloan Kettering Cancer Center; National Cancer Institute [P30CA016520,
   P30CA008748] Funding Source: NIH RePORTER
FX Research related to the development of this paper was supported in part
   by National Cancer Institute grants to the University of Pennsylvania
   Abramson Cancer Center (2P30CA016520-40) and the Memorial Sloan
   Kettering Cancer Center (3P30CA008748-50), the Byrne Fund, and the
   Translational Research and Integrative Medicine Fund at Memorial Sloan
   Kettering Cancer Center.
CR Ajzen I, 2011, PSYCHOL HEALTH, V26, P1113, DOI 10.1080/08870446.2011.613995
   American Association of Acupuncture and Oriental Medicine (AAAOM), 2009, POS STAT SUPP DES AC
   Austin Shamly, 2015, Health Mark Q, V32, P113, DOI [10.1080/07359683.2015.1033929, 10.1080/07359683.2015.1033929]
   Ballantyne JC, 2015, JAMA-J AM MED ASSOC, V313, P1059, DOI 10.1001/jama.2015.0521
   Bao T, 2018, ACUPUNCT MED, V36, P80, DOI 10.1136/acupmed-2017-011435
   Barclay JS, 2014, SUPPORT CARE CANCER, V22, P1883, DOI 10.1007/s00520-014-2167-6
   Bauml JM, 2015, CANCER-AM CANCER SOC, V121, P2431, DOI 10.1002/cncr.29173
   Bennett Mike, 2017, Am Soc Clin Oncol Educ Book, V37, P705, DOI [10.1200/edbk_180469, 10.14694/EDBK_180469]
   Bishop FL, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-102
   Bishop FL, 2011, BMC HEALTH SERV RES, V11, DOI 10.1186/1472-6963-11-129
   Bonafede M, 2008, MED CARE, V46, P41, DOI 10.1097/MLR.0b013e3181589b7d
   Breuer B, 2011, J CLIN ONCOL, V29, P4769, DOI 10.1200/JCO.2011.35.0561
   Brummett CM, 2017, JAMA SURG, V152, DOI 10.1001/jamasurg.2017.0504
   Chuang E, 2018, J ALTERN COMPLEM MED, V24, P336, DOI 10.1089/acm.2017.0262
   Clarke Hance, 2014, BMJ, V348, pg1251, DOI 10.1136/bmj.g1251
   Davis RT, 2018, GLOB ADV HLTH MED, V7, P1
   Deandrea S, 2008, ANN ONCOL, V19, P1985, DOI 10.1093/annonc/mdn419
   Dowell D, 2016, JAMA-J AM MED ASSOC, V315, P1624, DOI 10.1001/jama.2016.1464
   Enblom A, 2017, ACUPUNCT MED, V35, P251, DOI 10.1136/acupmed-2015-011007
   Everdingen MHJVDBV, 2007, ANN ONCOL, V18, P1437, DOI 10.1093/annonc/mdm056
   Frankel E, 2014, EUR J INTEGR MED, V6, P532, DOI 10.1016/j.eujim.2014.06.007
   Green CR, 2011, CANCER-AM CANCER SOC, V117, P1994, DOI 10.1002/cncr.25761
   Han B, 2017, ANN INTERN MED, V167, P293, DOI 10.7326/M17-0865
   Henry J., EMPLOYER HLTH BENEFI
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hirai K, 2008, ANN ONCOL, V19, P49, DOI 10.1093/annonc/mdm494
   Hopton A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056806
   Jabbour MJ, 2009, AM ACUPUNCT, V49, P1
   Judson PL, 2017, INTEGR CANCER THER, V16, P96, DOI 10.1177/1534735416660384
   Kim SY, 2012, ACUPUNCT MED, V30, P273, DOI 10.1136/acupmed-2012-010178
   Kligler B, 2015, J ALTERN COMPLEM MED, V21, P713, DOI 10.1089/acm.2014.0376
   Kwon JH, 2014, J CLIN ONCOL, V32, P1727, DOI 10.1200/JCO.2013.52.4827
   Lafferty WE, 2006, AM J MANAG CARE, V12, P397
   Lee JSJ, 2017, J CLIN ONCOL, V35, P4042, DOI 10.1200/JCO.2017.74.1363
   Lino S, 2014, COMPLEMENT THER MED, V22, P400, DOI 10.1016/j.ctim.2014.03.002
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Lu WD, 2013, CURR PAIN HEADACHE R, V17, DOI 10.1007/s11916-013-0321-3
   Mao JJ, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/798098
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   McKee MD, 2013, J AM BOARD FAM MED, V26, P692, DOI 10.3122/jabfm.2013.06.130003
   Mckee MD, 2012, J ALTERN COMPLEM MED, V18, P839, DOI 10.1089/acm.2011.0193
   Meghani SH, 2014, J CLIN ONCOL, V32, P2773, DOI 10.1200/JCO.2013.54.7992
   Meghani SH, 2012, PAIN MED, V13, P150, DOI 10.1111/j.1526-4637.2011.01310.x
   Nahin Richard L, 2016, NCHS Data Brief, P1
   Oh B, 2017, ACUPUNCT MED, V35, P107, DOI 10.1136/acupmed-2016-011115
   Paice JA, 2016, J ONCOL PRACT, V12, P757, DOI 10.1200/JOP.2016.014837
   Prochaska J.O., 2008, HLTH BEHAV HLTH ED T, V4th, P97
   Schwehr NA, 2018, ACUPUNCT MED, V36, P88, DOI 10.1136/acupmed-2016-011341
   Sohn H, 2017, POPUL RES POLICY REV, V36, P181, DOI 10.1007/s11113-016-9416-y
   Soneji N, 2016, JAMA SURG, V151, P1083, DOI 10.1001/jamasurg.2016.1681
   Tanco K, 2014, PALLIAT SUPPORT CARE, V12, P515, DOI 10.1017/S1478951514000091
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Weeks J, 2016, J ALTERN COMPLEM MED, V22, P947, DOI 10.1089/acm.2016.29016.jjw
   Zhang Y, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/710750
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 56
TC 23
Z9 24
U1 0
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD OCT
PY 2019
VL 20
IS 10
BP 2060
EP 2068
DI 10.1093/pm/pnz087
PG 9
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; General & Internal Medicine
GA JP1SN
UT WOS:000498052000022
PM 31329938
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Liang, Y
   Bao, GA
   Gong, LY
   Zhou, J
   Kong, XM
   Ran, R
   Shao, XM
   Jiang, YL
   Zhang, WP
   Liu, BY
   Du, JY
   Fang, JF
   Nie, N
   Ji, CH
   Fang, JQ
AF Liang, Yi
   Bao, Guanai
   Gong, Liyan
   Zhou, Jie
   Kong, Xiangming
   Ran, Ran
   Shao, Xiaomei
   Jiang, Yongliang
   Zhang, Weiping
   Liu, Boyi
   Du, Junying
   Fang, Junfan
   Nie, Na
   Ji, Conghua
   Fang, Jianqiao
TI Evaluating the analgesic effect and advantage of transcutaneous
   electrical acupoint stimulation combined with opioid drugs for moderate
   to severe cancer-related pain: a study protocol for a randomized
   controlled trial
SO TRIALS
LA English
DT Article
DE Study protocol; Randomized controlled trial; TEAS; Cancer-related pain
ID NERVE-STIMULATION; ACUPUNCTURE; PREVALENCE; RELIEF; MORPHINE; SURGERY;
   LABOR; TENS
AB BackgroundTranscutaneous electrical acupoint stimulation (TEAS), which is also known as acupuncture-like transcutaneous electrical nerve stimulation (TENS), has been widely used in acute or chronic pain. However, previous research has not demonstrated that TEAS is effective for cancer-related pain. Opioid drugs are strongly recommended for treating cancer-related pain, but opioid-induced immunosuppression is still the most intractable drug-induced medical problem. Evaluating the efficacy and potential advantage of TEAS combined with opioid drugs in moderate and severe cancer-related pain in China is important because such studies are lacking.Methods/DesignThis trial is a multicenter, prospective randomized controlled clinical trial. In total, 160 patients who were enrolled from two hospitals in the Zhejiang Province (China) will be randomly allocated into two groups: a TEAS group and sham TEAS group without acupoint electrical stimulation. Both groups will receive a 21-day interval of chemotherapy and conventional cancer pain therapy. Fifteen treatment sessions will be performed over a three-week period. The primary outcomes will be measured by changes in the Numerical Rating Scale (NRS) scores and equivalent dosage of morphine at baseline, three weeks of treatment and one two-week follow-up. The secondary outcome measures include cellular immunity function, life quality assessment, opioids side effects assessment, and safety and compliance evaluation.DiscussionThis trial is expected to clarify whether TEAS is effective for cancer-related pain. These results demonstrate the advantage of TEAS combined with opioid drugs on improving immune function and decreasing opioid induced side effects.Trial registrationChinese Clinical Trial Registry, ChiCTR-13003803. Registered on 27 August 2013.
C1 [Liang, Yi; Zhou, Jie; Ran, Ran; Shao, Xiaomei; Jiang, Yongliang; Zhang, Weiping; Du, Junying; Fang, Junfan; Nie, Na; Fang, Jianqiao] Zhejiang Chinese Med Univ, Dept Acupuncture, Affiliated Hosp 3, 219 Moganshan Rd, Hangzhou 310005, Zhejiang, Peoples R China.
   [Liang, Yi; Shao, Xiaomei; Jiang, Yongliang; Liu, Boyi; Du, Junying; Fang, Junfan; Fang, Jianqiao] Zhejiang Chinese Med Univ, Clin Med Coll 3, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.
   [Bao, Guanai; Gong, Liyan; Kong, Xiangming] Zhejiang Canc Hosp, 1 Banshan East Rd, Hangzhou 310022, Zhejiang, Peoples R China.
   [Ji, Conghua] Zhejiang Prov Hosp TCM, Clin Res Inst, 54 Youdian Rd, Hangzhou 310006, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Zhejiang Cancer Hospital; Zhejiang Chinese Medical
   University
RP Fang, JQ (corresponding author), Zhejiang Chinese Med Univ, Dept Acupuncture, Affiliated Hosp 3, 219 Moganshan Rd, Hangzhou 310005, Zhejiang, Peoples R China.; Fang, JQ (corresponding author), Zhejiang Chinese Med Univ, Clin Med Coll 3, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.
EM fangjianqiao7532@163.com
RI Ran, Ran/AHC-1848-2022; Du, Junying/AEV-3719-2022
OI Fang, Jianqiao/0000-0002-5155-8544
FU National Natural Science Foundation of China [81102643, 81674061];
   Foundation of the Zhejiang Health Committee [2014KYA162]
FX This study is supported by the National Natural Science Foundation of
   China (No. 81102643, 81674061) and the Foundation of the Zhejiang Health
   Committee (No. 2014KYA162). Sponsor and funders of this study do not
   have influence or authority regarding collection, management, analysis,
   and interpretation of data, writing of the report, or the decision to
   submit the report for publication.
CR [Anonymous], 2016, EVID-BASED COMPL ALT, DOI DOI 10.1155/2016/1720239
   Cabioglu MT, 2008, AM J CHINESE MED, V36, P25, DOI 10.1142/S0192415X08005552
   Chao AS, 2007, PAIN, V127, P214, DOI 10.1016/j.pain.2006.08.016
   Chesterton LS, 2009, BMC MUSCULOSKEL DIS, V10, DOI 10.1186/1471-2474-10-156
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Colson J, 2011, PAIN PHYSICIAN, V14, pE85
   Deandrea S, 2008, ANN ONCOL, V19, P1985, DOI 10.1093/annonc/mdn419
   Deandrea S, 2014, J PAIN SYMPTOM MANAG, V47, P57, DOI 10.1016/j.jpainsymman.2013.02.015
   Everdingen MHJVDBV, 2007, ANN ONCOL, V18, P1437, DOI 10.1093/annonc/mdm056
   Gavronsky S, 2012, PAIN MANAG NURS, V13, P150, DOI 10.1016/j.pmn.2009.08.001
   Houghtling RA, 2000, ANN NY ACAD SCI, V917, P771
   Hurlow A, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006276.pub3
   Johnson MI, 2011, EXPERT REV NEUROTHER, V11, P735, DOI [10.1586/ern.11.48, 10.1586/ERN.11.48]
   Lan F, 2012, MINERVA ANESTESIOL, V78, P887
   MELZACK R, 1984, POSTGRAD MED J, V60, P893, DOI 10.1136/pgmj.60.710.893
   Neufeld NJ, 2017, FUTURE ONCOL, V13, P833, DOI 10.2217/fon-2016-0423
   Page G G, 1997, Semin Oncol Nurs, V13, P10, DOI 10.1016/S0749-2081(97)80044-7
   Paley CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub3
   Peng T, 2010, CHIN J INTEGR MED, V16, P234, DOI 10.1007/s11655-010-0234-9
   Robb K, 2009, J PAIN SYMPTOM MANAG, V37, P746, DOI 10.1016/j.jpainsymman.2008.03.022
   Sacerdote P, 2006, PALLIATIVE MED, V20, pS9, DOI 10.1191/0269216306pm1124oa
   Sacerdote P, 2000, ANESTH ANALG, V90, P1411, DOI 10.1097/00000539-200006000-00028
   Searle RD, 2009, J PAIN SYMPTOM MANAG, V37, P424, DOI 10.1016/j.jpainsymman.2008.03.017
   Singhal P, 2001, ADV EXP MED BIOL, V493, P127
   Sun K, 2017, CLIN J PAIN, V33, P340, DOI 10.1097/AJP.0000000000000400
   Wei G, 2003, BIOCHEM PHARMACOL, V65, P1761, DOI 10.1016/S0006-2952(03)00085-6
   Wu HX, 2016, EXP THER MED, V11, P495, DOI 10.3892/etm.2015.2913
NR 27
TC 14
Z9 16
U1 3
U2 31
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JAN 11
PY 2019
VL 20
AR 40
DI 10.1186/s13063-018-3145-y
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HH2EI
UT WOS:000455531100004
PM 30635007
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Quinlan-Woodward, J
   Gode, A
   Dusek, JA
   Reinstein, AS
   Johnson, JR
   Sendelbach, S
AF Quinlan-Woodward, Jessica
   Gode, Autumn
   Dusek, Jeffery A.
   Reinstein, Adam S.
   Johnson, Jill R.
   Sendelbach, Sue
TI Assessing the Impact of Acupuncture on Pain, Nausea, Anxiety, and Coping
   in Women Undergoing a Mastectomy
SO ONCOLOGY NURSING FORUM
LA English
DT Article
DE anxiety; pain; nausea/vomiting; breast cancer; acupuncture
ID ACUTE POSTOPERATIVE PAIN; INTEGRATIVE MEDICINE; CANCER-PATIENTS;
   BREAST-CANCER; MANAGEMENT; MECHANISMS; INPATIENTS; SURGERY; ADULTS; CARE
AB Purpose/Objectives: To compare the effect of acupuncture to a standard-of-care (control) group on pain, nausea, anxiety, and ability to cope.
   Design: Pilot randomized, controlled trial.
   Setting: Abbott Northwestern Hospital, a large, urban, tertiary care hospital in Minneapolis, Minnesota.
   Sample: 30 adult women undergoing surgery for breast cancer.
   Methods: Women were randomly assigned to two hospital-based acupuncture treatments versus usual care after breast cancer surgery. Pain, nausea, anxiety, and the patient's ability to cope pre-and post-treatment were compared within and between groups at two different time points postoperatively.
   Main Research Variables: Mean change in pain, nausea, anxiety, and ability to cope by treatment group.
   Findings: Compared to women assigned to the control group, women who received acupuncture reported a statistically significant greater reduction in pain, nausea, anxiety, and increase in ability to cope on the first postoperative day and in pain on the second postoperative day following mastectomy surgery.
   Conclusions: Acupuncture delivered postoperatively in the hospital after mastectomy can reduce the severity of symptoms experienced, as well as increase the patient's ability to cope with her symptoms. However, before implementation as a standard of care, further research needs to be conducted.
   Implications for Nursing: Acupuncture adds a nonpharmacologic intervention for symptom management in women undergoing mastectomies for breast cancer.
C1 [Quinlan-Woodward, Jessica; Gode, Autumn; Reinstein, Adam S.; Johnson, Jill R.] Abbott NW Hosp, Penny George Inst Hlth & Healing, Minneapolis, MN 55407 USA.
   [Dusek, Jeffery A.] Abbott NW Hosp, Penny George Inst Hlth & Healing, Res, Minneapolis, MN USA.
   [Sendelbach, Sue] Abbott NW Hosp, Nursing Res, Minneapolis, MN USA.
RP Quinlan-Woodward, J (corresponding author), Abbott NW Hosp, Penny George Inst Hlth & Healing, Minneapolis, MN 55407 USA.
EM jessica.quinlan@allina.com
OI Dusek, Jeffery/0000-0001-9581-0564
CR [Anonymous], 2015, NCCN clinical practice guidelines in oncology: Prostate cancer
   [Anonymous], 2016, WHAT AR KEY STAT BRE
   Chae Y, 2008, NEUROSCI LETT, V430, P98, DOI 10.1016/j.neulet.2007.10.026
   Cheong KB, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082474
   Cho YH, 2015, PAIN PRACT, V15, P279, DOI 10.1111/papr.12208
   Collins AS, 2011, CRIT CARE NURSE, V31, P36, DOI 10.4037/ccn2011470
   Crespin DJ, 2015, PAIN MED, V16, P1195, DOI 10.1111/pme.12685
   Dibble SL, 2007, ONCOL NURS FORUM, V34, P815, DOI 10.1188/07.ONF.813-820
   Elkins Gary, 2004, Clin Nurs Res, V13, P237, DOI 10.1177/1054773803262222
   Fecho K, 2009, PAIN MED, V10, P708, DOI 10.1111/j.1526-4637.2009.00611.x
   Greenlee Heather, 2014, Journal of the National Cancer Institute Monographs, P346, DOI 10.1093/jncimonographs/lgu041
   Hjermstad MJ, 2011, J PAIN SYMPTOM MANAG, V41, P1073, DOI 10.1016/j.jpainsymman.2010.08.016
   Hutchison RW, 2007, AM J HEALTH-SYST PH, V64, pS2, DOI 10.2146/ajhp060679
   Johnson JR, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-486
   Johnson Jill R., 2014, Journal of the National Cancer Institute Monographs, P330, DOI 10.1093/jncimonographs/lgu030
   Kreindler G., 2014, EVID-BASED COMPL ALT, V2014, DOI [10.1155/2014/120486, DOI 10.1155/2014/120486]
   Lee A, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003281.pub3
   LoBiondo-Wood G, 2014, ONCOL NURS FORUM, V41, P67, DOI 10.1188/14.ONF.67-76
   Mallory MJ, 2015, AM J CHINESE MED, V43, P45, DOI 10.1142/S0192415X15500032
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   Mehling WE, 2007, J PAIN SYMPTOM MANAG, V33, P258, DOI 10.1016/j.jpainsymman.2006.09.016
   National Center for Complementary and Integrative Health, 2015, US COMPL HLTH APPR U
   Park HJ, 2005, NEUROSCI LETT, V377, P179, DOI 10.1016/j.neulet.2004.11.097
   Pfister DG, 2010, J CLIN ONCOL, V28, P2565, DOI 10.1200/JCO.2009.26.9860
   Potter S, 2009, BRIT J SURG, V96, P613, DOI 10.1002/bjs.6605
   Stone JAM, 2010, CURR TREAT OPTION ON, V11, P118, DOI 10.1007/s11864-010-0128-y
   Tada H, 2003, DIGEST DIS SCI, V48, P59, DOI 10.1023/A:1021730314068
   Vase L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119612
   Wang SM, 2008, ANESTH ANALG, V106, P602, DOI 10.1213/01.ane.0000277493.42335.7b
   Ware LJ, 2011, PAIN MANAG NURS, V12, P25, DOI 10.1016/j.pmn.2009.12.001
NR 30
TC 40
Z9 46
U1 0
U2 41
PU ONCOLOGY NURSING SOC
PI PITTSBURGH
PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA
SN 0190-535X
EI 1538-0688
J9 ONCOL NURS FORUM
JI Oncol. Nurs. Forum
PD NOV
PY 2016
VL 43
IS 6
BP 725
EP 732
DI 10.1188/16.ONF.725-732
PG 8
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA EA1EY
UT WOS:000386336500013
PM 27768139
DA 2026-01-16
ER

PT J
AU Kim, HW
   Yoo, JE
AF Kim, Hae-Won
   Yoo, Jeong-Eun
TI Inhibitory effect of traditional Korean medicine on the recurrent
   endometriosis after laparoscopic excision: a case report
SO INTEGRATIVE MEDICINE RESEARCH
LA English
DT Article
DE Boheotang; Dienogest; Endometriosis; Laparoscopic surgery; traditional
   Korean medicine
ID DIENOGEST; MULTICENTER; SYMPTOMS; ACETATE; TRIAL; WOMEN; PAIN
AB Endometriosis is a common benign gynecologic tumor, and it can destroy a patient's life. Surgery and hormone therapy are established therapies for endometriosis. However, there are many cases of recurrent endometriosis after conventional therapies. This report presents a case of a patient who has repetitive recurrence of endometriosis after laparoscopic excision and hormone therapy. A 32-years-old female patient first had laparoscopic surgery to remove endometriosis in 2011. The disease recurred two more times after the first excision. Hormone therapy by dienogest and two more laparoscopic surgeries were done in 2012 and 2014. With acupuncture, moxibustion, fumigation therapy, and herbal medicine therapy, endometriosis didn't recur during treatment and observation period of 34 months. Menstrual pain numeric rating scales (NRS) decreased from 2 to none. Shortened menstrual cycle (24 days) after second surgery became longer (26.63 +/- 2.28 days) after traditional Korean medicine therapy. This case presents the therapeutic potential of TKM for inhibitory effect on the recurrent endometriosis after laparoscopic excision and hormone therapy. (C) 2018 Korea Institute of Oriental Medicine. Publishing services by Elsevier B.V.
C1 [Kim, Hae-Won; Yoo, Jeong-Eun] Dae Jeon Univ, Dept Korean Med Obstet & Gynecol, Coll Korean Med, Daejeon, South Korea.
RP Yoo, JE (corresponding author), Dae Jeon Univ, Dept Korean Med Obstet & Gynecol, Dunsan Korean Med Hosp, 75 Daeduk Daero 176 Beon Gil, Daejeon 35235, South Korea.
EM jeyoo@dju.ac.kr
CR Abbott JA, 2003, HUM REPROD, V18, P1922, DOI 10.1093/humrep/deg275
   [Anonymous], 2008, FERTIL STERIL, V90, pS260, DOI 10.1016/j.fertnstert.2008.08.057
   [Anonymous], J KOREAN OBSTET GYNE
   [Anonymous], BR J OBSTET GYNAECOL
   Chan RYK, 2002, J CLIN ENDOCR METAB, V87, P3691, DOI 10.1210/jc.87.8.3691
   Cosson M, 2002, FERTIL STERIL, V77, P684, DOI 10.1016/S0015-0282(01)03270-8
   Dong-Il-Kim, 2002, [The Journal of Oriental Obstetrics ＆ Gynecology, 대한한방부인과학회지], V15, P126
   Farquhar CM, 2000, BMJ-BRIT MED J, V320, P1449, DOI 10.1136/bmj.320.7247.1449
   Garry R, 2004, CURR OPIN OBSTET GYN, V16, P299, DOI 10.1097/01.gco.0000136496.95075.79
   Harada T, 2009, FERTIL STERIL, V91, P675, DOI 10.1016/j.fertnstert.2007.12.080
   Holoch KJ, 2010, CLIN OBSTET GYNECOL, V53, P429, DOI 10.1097/GRF.0b013e3181db7d71
   정명주, 2015, [The Journal of Oriental Obstetrics ＆ Gynecology, 대한한방부인과학회지], V28, P87, DOI [10.15204/jkobgy.2015.28.3.087, 10.15204/jkobgy.2015.28.3.087]
   Kang AR, 2010, J KOREAN MED ASSOC, V53, P424, DOI 10.5124/jkma.2010.53.5.424
   Kennedy S, 2005, HUM REPROD, V20, P2698, DOI 10.1093/humrep/dei135
   Lee EunBang Lee EunBang, 1999, Korean Journal of Pharmacognosy, V30, P137
   OOSTERLYNCK DJ, 1991, FERTIL STERIL, V56, P45
   Petraglia F, 2012, ARCH GYNECOL OBSTET, V285, P167, DOI 10.1007/s00404-011-1941-7
   Schindler AE, 2011, INT J WOMENS HEALTH, V3, P175, DOI 10.2147/IJWH.S5633
   Strowitzki T, 2010, HUM REPROD, V25, P633, DOI 10.1093/humrep/dep469
   조현정, 2007, [The Journal of Oriental Obstetrics ＆ Gynecology, 대한한방부인과학회지], V20, P202
   이혜인, 2017, [The Journal of Oriental Obstetrics ＆ Gynecology, 대한한방부인과학회지], V30, P107, DOI [10.15204/jkobgy.2017.30.2.107, 10.15204/jkobgy.2017.30.2.107]
   백선은, 2015, [The Journal of Oriental Obstetrics ＆ Gynecology, 대한한방부인과학회지], V28, P119, DOI [10.15204/jkobgy.2015.28.3.119, 10.15204/jkobgy.2015.28.3.119]
   조정훈, 2009, [The Journal of Oriental Obstetrics ＆ Gynecology, 대한한방부인과학회지], V22, P172
NR 31
TC 4
Z9 5
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4220
EI 2213-4239
J9 INTEGR MED RES
JI Integr. Med. Res.
PD SEP
PY 2018
VL 7
IS 3
BP 296
EP 301
DI 10.1016/j.imr.2018.07.003
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GV1GA
UT WOS:000445817600012
PM 30271719
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Masuyama, S
   Yamashita, H
   Amino, T
   Kawamoto, R
   Tsuji, R
   Nakanishi, H
   Yoshida, H
AF Masuyama, Shoko
   Yamashita, Hitoshi
   Amino, Tamami
   Kawamoto, Ryouko
   Tsuji, Ryota
   Nakanishi, Hiromoto
   Yoshida, Hiroshi
TI Acupuncture for patients with Cancer in a Japanese palliative care team:
   A prospective case series study
SO INTEGRATIVE MEDICINE RESEARCH
LA English
DT Article
DE Acupuncture; Cancer patient; Palliative care; Japan; Case series
ID PAIN; MANAGEMENT; MEDICINE; TRIALS
AB Background: The joint guidelines of the Society for Integrative Oncology and the American Society of Clinical Oncology recommend acupuncture for pain symptoms in some patients with cancer. This study assessed whether adding acupuncture to usual palliative care alleviates the subjective symptoms of hospitalized patients with cancer in Japan, at least in the short term. Methods: Between 2015 and 2019, we conducted a prospective case series study at a regional core hospital in Osaka. Acupuncture was included in the usual care of patients with cancer. The primary outcome was immediate changes in each patient's subjective symptoms measured by a 10 cm visual analog scale (VAS). A 20 % reduction in VAS was set as the minimal clinically important difference (MCID). Results: A total of 83 cancer patients (mean age: 66.1) were treated with acupuncture. A significant reduction was observed in the VAS scores for pain, edema, nausea, neck/shoulder/back stiffness, and breathlessness during at least one treatment session. The percentage of patients that improved beyond the MCID was as follows: 67 % for pain, 75 % for edema, 60 % for paresthesia, 80 % for nausea, 88 % for stiffness, 38 % for malaise, and 83 % for breathlessness, based on the maximum improvement recorded per session. Conclusion: Japanese-style acupuncture, with relatively finer needles and gentler stimulation, has shown promise as a palliative treatment for patients with cancer, potentially offering temporary relief from pain, edema, nausea, stiffness, and breathlessness. Based on our findings, a pragmatic randomized controlled trial with an appropriate control group is recommended.
C1 [Masuyama, Shoko; Yamashita, Hitoshi] Morinomiya Univ Med Sci, Grad Sch Hlth Sci, Osaka, Japan.
   [Masuyama, Shoko; Yamashita, Hitoshi; Tsuji, Ryota; Nakanishi, Hiromoto] Morinomiya Univ Med Sci, Dept Acupuncture, Osaka, Japan.
   [Amino, Tamami; Kawamoto, Ryouko; Yoshida, Hiroshi] Osaka Gen Med Ctr, Osaka, Japan.
RP Yamashita, H (corresponding author), Morinomiya Univ Med Sci, 1-26-16 Nanko Kita,Suminoe Ku, Osaka 5598611, Japan.
EM yamashita@morinomiya-u.ac.jp
OI Masuyama, Shoko/0000-0003-4273-331X
FU JSPS [20K10334]
FX <STRONG> </STRONG>This work was partly supported by the JSPS
   Grants-in-Aid for Scientific Research (KAKENHI) (Grant Number: 20K10334)
   .
CR [Anonymous], 2015, Palliative Care Fact Sheet
   [Anonymous], 2022, jamovi (Version 2.3). jamovi website
   Birch S, 1998, Japanese acupuncture: a Clinical Guide, P39
   Birch S, 2022, INTEGR MED RES, V11, DOI 10.1016/j.imr.2022.100834
   Chae Y, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00243
   Cheong KB, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082474
   de Valois B, 2024, SUPPORT CARE CANCER, V32, DOI 10.1007/s00520-024-08386-6
   Dworkin RH, 2008, J PAIN, V9, P105, DOI 10.1016/j.jpain.2007.09.005
   Garcia MK, 2018, INTEGR CANCER THER, V17, P148, DOI 10.1177/1534735416685403
   Guo J, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420959442
   Haynes RB, 2002, BMJ-BRIT MED J, V324, P1350, DOI 10.1136/bmj.324.7350.1350
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Henson LA, 2020, J CLIN ONCOL, V38, P905, DOI 10.1200/JCO.19.00470
   Hyodo I, 2005, J CLIN ONCOL, V23, P2645, DOI 10.1200/JCO.2005.04.126
   Ishizaki N, 2010, EVID-BASED COMPL ALT, V7, P493, DOI 10.1093/ecam/nen037
   Jin B, 2024, COMPLEMENT THER MED, V85, DOI 10.1016/j.ctim.2024.103079
   Kivity O, 2018, Eur J Orient Med, V9, P16
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Masuyama S, 2023, BMC COMPLEMENT MED, V23, DOI 10.1186/s12906-023-03910-3
   Mathew G, 2023, INT J SURG, V109, P3760, DOI 10.1097/JS9.0000000000000940
   Okawa Y, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0292729
   Shirota B, 1940, Shinkyu Chiryo Kiso Gaku
   Suzuki M, 2012, ARCH INTERN MED, V172, P878, DOI 10.1001/archinternmed.2012.1233
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Yamashita H, 1999, J ALTERN COMPLEM MED, V5, P229, DOI 10.1089/acm.1999.5.229
   Yan YQ, 2023, CANCER MED-US, V12, P12504, DOI 10.1002/cam4.5962
NR 27
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4220
EI 2213-4239
J9 INTEGR MED RES
JI Integr. Med. Res.
PD MAR
PY 2026
VL 15
IS 1
AR 101212
DI 10.1016/j.imr.2025.101212
EA AUG 2025
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 6XJ5O
UT WOS:001564280400001
PM 40933787
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Gonzalez-Guerrero, JF
   Alcorta-Garza, AG
   Alcorta-Nuñez, F
   Melgoza-Alcorta, EM
   Gonzalez-Rodriguez, M
   Gonzalez-Alcorta, CB
   Alcorta-Garza, A
AF Francisco Gonzalez-Guerrero, Juan
   Gloria Alcorta-Garza, Antonia
   Alcorta-Nunez, Fernando
   Maria Melgoza-Alcorta, Emma
   Gonzalez-Rodriguez, Melany
   Beatriz Gonzalez-Alcorta, Celia
   Alcorta-Garza, Adelina
TI Association of the quality of psychosocial support and quality of life
   in patients with chronic oncological pain.
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)
CY MAY 31-JUN 04, 2019
CL Chicago, IL
SP Amer Soc Clin Oncol
C1 UANL, Monterrey, NL, Mexico.
   UANL, San Pedro Garza Garcia, Mexico.
   Univ Hosp, Monterrey, Mexico.
C3 Universidad Autonoma de Nuevo Leon; Universidad Autonoma de Nuevo Leon
NR 0
TC 1
Z9 1
U1 0
U2 2
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2019
VL 37
IS 15
SU S
MA e23113
DI 10.1200/JCO.2019.37.15_suppl.e23113
PG 1
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology
GA IZ8HT
UT WOS:000487345803152
DA 2026-01-16
ER

PT J
AU Liu, C
   Zhang, H
   Sun, CG
AF Liu, Cun
   Zhang, Heng
   Sun, Changgang
TI Acupuncture for Aromatase Inhibitor-Related Joint Pain Among Breast
   Cancer Patients
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Letter
ID SHAM ACUPUNCTURE; WOMEN
C1 [Liu, Cun; Zhang, Heng] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan, Shandong, Peoples R China.
   [Sun, Changgang] Weifang Tradit Chinese Hosp, Weifang, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine
RP Sun, CG (corresponding author), Weifang Tradit Chinese Hosp, Dept Tradit Chinese Med Oncol, Weifang 261000, Peoples R China.
EM zhongliuyike@163.com
RI Sun, Changgang/NXX-9480-2025
OI Sun, Changgang/0000-0003-0778-8788
CR Asghar AU, 2010, BRAIN RES, V1315, P111, DOI 10.1016/j.brainres.2009.12.019
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Kim KH, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005068
   Liu ZS, 2017, JAMA-J AM MED ASSOC, V317, P2493, DOI 10.1001/jama.2017.7220
   Wechsler ME, 2011, NEW ENGL J MED, V365, P119, DOI 10.1056/NEJMoa1103319
NR 5
TC 3
Z9 3
U1 0
U2 29
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD DEC 4
PY 2018
VL 320
IS 21
BP 2270
EP 2270
DI 10.1001/jama.2018.16740
PG 1
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HD4MB
UT WOS:000452500600022
PM 30512093
DA 2026-01-16
ER

PT J
AU Oberoi, DV
   Longo, CJ
   Reed, EN
   Landmann, J
   Piedalue, KAL
   Carlson, LE
AF Oberoi, Devesh V.
   Longo, Christopher J.
   Reed, Erica N.
   Landmann, Jessa
   Piedalue, Katherine-ann L.
   Carlson, Linda E.
TI GROUP ACUPUNCTURE IS MORE COST-EFFECTIVE THAN INDIVIDUAL ACUPUNCTURE FOR
   TREATING CANCER-RELATED PAIN
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Meeting Abstract
C1 [Oberoi, Devesh V.; Reed, Erica N.; Piedalue, Katherine-ann L.; Carlson, Linda E.] Univ Calgary, Calgary, AB, Canada.
   [Longo, Christopher J.] McMaster Univ, DeGroote Sch Business, Burlington, ON, Canada.
   [Landmann, Jessa] Vive Integrat Hlth Grp, Calgary, AB, Canada.
C3 University of Calgary; McMaster University
EM devesh.oberoi@ahs.ca
RI Carlson, Linda/AEN-5702-2022; Oberoi, Devesh/H-8299-2016
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD APR
PY 2021
VL 55
SU 1
BP S243
EP S243
PG 1
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA RZ9MM
UT WOS:000648922700492
DA 2026-01-16
ER

PT J
AU Plaut, S
AF Plaut, Shiloh
TI Suggesting a mechanism for acupuncture as a global percutaneous needle
   fasciotomy that respects tensegrity principles for treating fibromyalgia
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE acupuncture; fascial armoring; fibromyalgia; mechanism; myofibroblast;
   needling; pain; treatment
ID MYOFASCIAL TRIGGER POINTS; SMOOTH MUSCLE ACTIN; CONNECTIVE-TISSUE;
   UNDERLYING MECHANISMS; JOINT HYPERMOBILITY; CONTROLLED-TRIAL;
   DOUBLE-BLIND; PAIN; THERAPY; MANAGEMENT
AB Acupuncture is a minimally invasive therapeutic method that uses small caliber needles while inserting them through the skin into various areas of the body. Some empirical studies find evidence to support the use of acupuncture as a treatment for certain medical conditions, however, this peculiar practice is widely considered as the domain of alternative and non-evidence-based medicine. Several mechanisms have been suggested in an attempt to explain the therapeutic action of acupuncture, but the way in which acupuncture alleviates chronic non-cancer pain or psychosomatic and psychiatric disorders is not fully understood. A recent study suggested a theoretical model (coined "Fascial Armoring") with a cellular pathway to help explain the pathogenesis of myofascial pain/fibromyalgia syndrome and functional psychosomatic syndromes. It proposes that these syndromes are a spectrum of a single medical entity that involves myofibroblasts with contractile activity in fascia and aberrant extracellular matrix (ECM) remodeling, which may lead to widespread mechanical tension and compression. This can help explain diverse psycho-somatic manifestations of fibromyalgia-like syndromes. Fascia is a continuous interconnected tissue network that extends throughout the body and has qualities of bio-tensegrity. Previous studies show that a mechanical action by needling induces soft tissue changes and lowers the shear modulus and stiffness in myofascial tissue. This hypothesis and theory paper offers a new mechanism for acupuncture therapy as a global percutaneous needle fasciotomy that respects tensegrity principles (tensegrity-based needling), in light of the theoretical model of "Fascial Armoring." The translation of this model to other medical conditions carries potential to advance therapies. These days opioid overuse and over-prescription are ubiquitous, as well as chronic pain and suffering.
C1 [Plaut, Shiloh] Univ Nicosia, Dept Primary Care & Populat Hlth, Med Sch, Nicosia, Cyprus.
C3 University of Nicosia
RP Plaut, S (corresponding author), Univ Nicosia, Dept Primary Care & Populat Hlth, Med Sch, Nicosia, Cyprus.
EM shilowhale@gmail.com
RI Plaut, Shiloh/GQH-4459-2022; , Shiloh/GQH-4459-2022
OI , Shiloh/0000-0001-5823-3390
CR Acasuso-Díaz M, 1998, ARTHRIT CARE RES, V11, P39, DOI 10.1002/art.1790110107
   ARORA PD, 1994, J CELL PHYSIOL, V161, P187, DOI 10.1002/jcp.1041610202
   Balfour William, 1815, Edinb Med Surg J, V11, P168
   Bensoussan A, 2000, ARCH FAM MED, V9, P1071, DOI 10.1001/archfami.9.10.1071
   Bisson MA, 2003, J HAND SURG-BRIT EUR, V28B, P351, DOI 10.1016/S0266-7681(03)00135-9
   Bose A, 2018, MOL NEUROBIOL, V55, P6558, DOI 10.1007/s12035-017-0861-3
   Cabioglu MT, 2008, AM J CHINESE MED, V36, P25, DOI 10.1142/S0192415X08005552
   Caldeira P, 2020, SPORTS MED-OPEN, V6, DOI 10.1186/s40798-020-00253-y
   Calvo-Lobo C, 2018, J GERIATR PHYS THER, V41, P1, DOI 10.1519/JPT.0000000000000079
   Castella LF, 2010, J CELL SCI, V123, P1751, DOI 10.1242/jcs.066795
   Chen G, 2021, J PSYCHOSOM RES, V148, DOI 10.1016/j.jpsychores.2021.110556
   Chiarelli N, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10113236
   Chiarelli N, 2021, BBA-MOL BASIS DIS, V1867, DOI 10.1016/j.bbadis.2020.166051
   Cirka H, 2016, BIOPHYS J, V110, P1845, DOI 10.1016/j.bpj.2016.02.036
   Cummings TM, 2001, ARCH PHYS MED REHAB, V82, P986, DOI 10.1053/apmr.2001.24023
   De Meulemeester K, 2022, AM J PHYS MED REHAB, V101, P18, DOI 10.1097/PHM.0000000000001732
   Deare JC, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007070.pub2
   Discher DE, 2005, SCIENCE, V310, P1139, DOI 10.1126/science.1116995
   DORIGO B, 1979, PAIN, V6, P183, DOI 10.1016/0304-3959(79)90125-8
   Doss BL, 2020, P NATL ACAD SCI USA, V117, P12817, DOI 10.1073/pnas.1917555117
   Ernberg M, 1999, LIFE SCI, V65, P313, DOI 10.1016/S0024-3205(99)00250-7
   Ernst E, 1997, PAIN, V71, P123, DOI 10.1016/S0304-3959(97)03368-X
   Evdokimov D, 2020, J RHEUMATOL, V47, P140, DOI 10.3899/jrheum.190248
   Fernández-De-Las-Peñas C, 2021, PAIN RES MANAG, V2021, DOI 10.1155/2021/8836427
   Firestein G.S., 2013, KELLEYS TXB RHEUMATO, V9th
   Focks C., 2008, Atlas of Acupuncture
   Fox JR, 2014, J ALTERN COMPLEM MED, V20, P290, DOI 10.1089/acm.2013.0397
   FROST FA, 1980, LANCET, V1, P499
   Furlan AD, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001351.pub2
   Gattie E, 2017, J ORTHOP SPORT PHYS, V47, P133, DOI 10.2519/jospt.2017.7096
   GEDALIA A, 1993, ANN RHEUM DIS, V52, P494, DOI 10.1136/ard.52.7.494
   Geist KT, 2021, J BODYW MOV THER, V26, P158, DOI 10.1016/j.jbmt.2020.12.021
   Gerdle B, 2010, J REHABIL MED, V42, P679, DOI 10.2340/16501977-0581
   Goffin JM, 2006, J CELL BIOL, V172, P259, DOI 10.1083/jcb.200506179
   Grafstein B, 2000, ANN NEUROL, V47, P18, DOI 10.1002/1531-8249(200001)47:1<18::AID-ANA6>3.3.CO;2-E
   Gronemann ST, 2004, RHEUMATOLOGY, V43, P27, DOI 10.1093/rheumatology/keg452
   Gu Y, 2012, BIOMATERIALS, V33, P6672, DOI 10.1016/j.biomaterials.2012.06.006
   Guo Q, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.713548
   Harty J, 2005, FOOT ANKLE INT, V26, P1089, DOI 10.1177/107110070502601215
   Hopwood V., 2004, ACUPUNCTURE PHYSIOTH, V1st
   Hsieh YL, 2011, ARCH PHYS MED REHAB, V92, P1098, DOI 10.1016/j.apmr.2010.11.018
   Hu HT, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011225
   Jiang WB, 2020, SPINE, V45, pE1296, DOI 10.1097/BRS.0000000000003602
   Kalia V, 2021, J BODYW MOV THER, V25, P146, DOI 10.1016/j.jbmt.2020.10.014
   KALYANRAMAN UP, 1984, J RHEUMATOL, V11, P808
   Kaptchuk TJ, 2002, ANN INTERN MED, V136, P374, DOI 10.7326/0003-4819-136-5-200203050-00010
   Karagounis Panagiotis, 2011, Foot Ankle Spec, V4, P226, DOI 10.1177/1938640011407320
   Katz RS, 2021, J RHEUMATOL, V48, P598, DOI 10.3899/jrheum.191068
   Kayal C, 2020, ADV HEALTHC MATER, V9, DOI 10.1002/adhm.201901036
   Kluger BM, 2016, MOVEMENT DISORD, V31, P1027, DOI 10.1002/mds.26597
   Kural MH, 2016, ACTA BIOMATER, V32, P223, DOI 10.1016/j.actbio.2015.12.031
   Labovitz Jonathan M, 2011, Foot Ankle Spec, V4, P141, DOI 10.1177/1938640010397341
   Langevin HM, 2007, J ALTERN COMPLEM MED, V13, P355, DOI 10.1089/acm.2007.6351
   Langevin Helene M., 2002, Anatomical Record, V269, P257, DOI 10.1002/ar.10185
   Langevin HM, 2006, J CELL PHYSIOL, V207, P767, DOI 10.1002/jcp.20623
   Langevin HM, 2004, HISTOCHEM CELL BIOL, V122, P7, DOI 10.1007/s00418-004-0667-z
   Langevin HM, 2002, FASEB J, V16, P872, DOI 10.1096/fj.01-0925fje
   Langevin HM, 2004, ULTRASOUND MED BIOL, V30, P1173, DOI 10.1016/j.ultrasmedbio.2004.07.010
   Langevin HM, 2001, FASEB J, V15, P2275, DOI 10.1096/fj.01-0015hyp
   Langevin HM, 2001, J APPL PHYSIOL, V91, P2471, DOI 10.1152/jappl.2001.91.6.2471
   LEWIT K, 1979, PAIN, V6, P83, DOI 10.1016/0304-3959(79)90142-8
   Li ADR, 2021, IEEE T BIO-MED ENG, V68, P1477, DOI 10.1109/TBME.2021.3054922
   Li ADR, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-68596-w
   Li XX, 2017, PAIN PHYSICIAN, V20, pE882
   Linde K, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001218.pub3
   Linde K, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007587.pub2
   Liu L, 2018, ARCH PHYS MED REHAB, V99, P144, DOI 10.1016/j.apmr.2017.06.008
   Liu L, 2015, ARCH PHYS MED REHAB, V96, P944, DOI 10.1016/j.apmr.2014.12.015
   Llamas-Ramos R, 2014, J ORTHOP SPORT PHYS, V44, P852, DOI 10.2519/jospt.2014.5229
   Lu LM, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj-2021-067475
   Luan S, 2019, AM J PHYS MED REHAB, V98, P677, DOI 10.1097/PHM.0000000000001173
   Lumley MA, 2017, PAIN, V158, P2354, DOI 10.1097/j.pain.0000000000001036
   Ma H, 2020, MACROMOL BIOSCI, V20, DOI 10.1002/mabi.202000268
   Maher RM, 2013, ARCH PHYS MED REHAB, V94, P2146, DOI 10.1016/j.apmr.2013.04.021
   Martín-Pintado-Zugasti A, 2018, J BODYW MOV THER, V22, P941, DOI 10.1016/j.jbmt.2018.01.003
   Mejuto-Vázquez MJ, 2014, J ORTHOP SPORT PHYS, V44, P252, DOI 10.2519/jospt.2014.5108
   Melchart D, 2005, BMJ-BRIT MED J, V331, P376, DOI 10.1136/bmj.38512.405440.8F
   MELZACK R, 1977, PAIN, V3, P3, DOI 10.1016/0304-3959(77)90032-X
   Mercier F, 2000, J COMP NEUROL, V420, P445, DOI 10.1002/(SICI)1096-9861(20000515)420:4<445::AID-CNE4>3.0.CO;2-3
   Mercier F, 2001, J COMP NEUROL, V431, P88, DOI 10.1002/1096-9861(20010226)431:1<88::AID-CNE1057>3.0.CO;2-D
   Mishra AK, 2014, AM J SPORT MED, V42, P463, DOI 10.1177/0363546513494359
   Mist SD, 2018, PAIN MED, V19, P1862, DOI 10.1093/pm/pnx322
   Moog P, 2019, ARCH ORTHOP TRAUM SU, V139, P1471, DOI 10.1007/s00402-019-03247-y
   Moraska AF, 2013, ARCH PHYS MED REHAB, V94, P196, DOI 10.1016/j.apmr.2012.08.216
   Morf S, 2005, ARTHRITIS RES THER, V7, pR209, DOI 10.1186/ar1459
   Ng CP, 2005, J CELL SCI, V118, P4731, DOI 10.1242/jcs.02605
   Nordez A, 2017, SPORTS MED, V47, P1925, DOI 10.1007/s40279-017-0703-5
   Padhi A, 2020, COMMUN BIOL, V3, DOI 10.1038/s42003-020-01117-7
   Perreault T, 2021, J CLIN MED, V10, DOI 10.3390/jcm10102189
   Plaut S, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0263087
   Raja GP, 2022, CLIN ANAT, V35, P340, DOI 10.1002/ca.23835
   Rajkannan P, 2019, J BODYW MOV THER, V23, P94, DOI 10.1016/j.jbmt.2018.01.004
   Ramírez-Tejero JA, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082386
   Sacheti A, 1997, J PAIN SYMPTOM MANAG, V14, P88, DOI 10.1016/S0885-3924(97)00007-9
   Sánchez-Infante J, 2021, J PAIN, V22, P817, DOI 10.1016/j.jpain.2021.02.004
   Sasabe R, 2017, J ORTHOP RES, V35, P1998, DOI 10.1002/jor.23498
   Scarr G, 2020, J BODYW MOV THER, V24, P134, DOI 10.1016/j.jbmt.2019.09.006
   Schleip R, 2019, CLIN ANAT, V32, P891, DOI 10.1002/ca.23391
   Schleip R, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00336
   Shah JP, 2008, J BODYW MOV THER, V12, P371, DOI 10.1016/j.jbmt.2008.06.006
   Shin KM, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-174
   Sluka KA, 2016, NEUROSCIENCE, V338, P114, DOI 10.1016/j.neuroscience.2016.06.006
   Smith CA, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004046.pub4
   Soiné JRD, 2016, INTERFACE FOCUS, V6, DOI 10.1098/rsfs.2016.0024
   Soreide E, 2018, BONE JOINT J, V100B, P1138, DOI 10.1302/0301-620X.100B9.BJJ-2017-1194.R2
   Sprott H, 2004, ANN RHEUM DIS, V63, P245, DOI 10.1136/ard.2002.004762
   Staud R, 2011, BEST PRACT RES CL RH, V25, P155, DOI 10.1016/j.berh.2010.01.010
   Stecco A, 2009, J BODYW MOV THER, V13, P53, DOI 10.1016/j.jbmt.2007.04.009
   Tadeo I, 2014, FRONT ONCOL, V4, DOI 10.3389/fonc.2014.00039
   Tan R., 1991, AM J SURG PATHOL
   TOMASEK JJ, 1992, ANAT REC, V232, P359, DOI 10.1002/ar.1092320305
   Tomasek JJ, 2002, NAT REV MOL CELL BIO, V3, P349, DOI 10.1038/nrm809
   VANDEBERG JS, 1982, PLAST RECONSTR SURG, V69, P835, DOI 10.1097/00006534-198205000-00021
   Vassaux M, 2017, BIOMECH MODEL MECHAN, V16, P1295, DOI 10.1007/s10237-017-0888-4
   Veith I., 1972, Huang ti nei ching su wen: The yellow emperor's classic of internal medicine
   Verjee LS, 2009, J HAND SURG-AM, V34A, P1785, DOI 10.1016/j.jhsa.2009.08.005
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Vincent C, 2001, BRIT MED J, V323, P467, DOI 10.1136/bmj.323.7311.467
   Wan R, 2021, WOUND REPAIR REGEN, V29, P573, DOI 10.1111/wrr.12954
   Wang WM, 2021, ACUPUNCT MED, V39, P272, DOI 10.1177/0964528420947739
   Wen JY, 2021, AM J CHINESE MED, V49, P1, DOI 10.1142/S0192415X21500014
   Wessely S, 1999, BEST PRACT RES CL RH, V13, P427, DOI 10.1053/berh.1999.0032
   Wilke J, 2019, CLIN ANAT, V32, P934, DOI 10.1002/ca.23424
   Wilke J, 2018, J APPL PHYSIOL, V124, P234, DOI 10.1152/japplphysiol.00565.2017
   Wilke J, 2016, ARCH PHYS MED REHAB, V97, P454, DOI 10.1016/j.apmr.2015.07.023
   WILLIAMS PE, 1984, J ANAT, V138, P343
   Wolfson B, 2017, MOL CELL BIOL, V37, DOI 10.1128/MCB.00461-16
   Wu LJ, 2007, CLIN BIOMECH, V22, P221, DOI 10.1016/j.clinbiomech.2006.09.009
   Yamashita H, 1998, JAMA-J AM MED ASSOC, V280, P1563, DOI 10.1001/jama.280.18.1563-a
   Yamashita H, 2001, COMPLEMENT THER MED, V9, P98, DOI 10.1054/ctim.2001.0446
   Yang WL, 2019, J MOL CELL CARDIOL, V134, P119, DOI 10.1016/j.yjmcc.2019.07.004
   Yang Z., 2020, YELLOW EMPERORS INNE
   Yip AK, 2013, BIOPHYS J, V104, P19, DOI 10.1016/j.bpj.2012.11.3805
   Yuan QL, 2016, SCI REP-UK, V6, DOI 10.1038/srep30675
   Zhang D, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nep050
   Zhang XC, 2019, J PAIN RES, V12, P527, DOI 10.2147/JPR.S186227
   Zheng N, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06863-z
   Zoppi N, 2018, BBA-MOL BASIS DIS, V1864, P1010, DOI 10.1016/j.bbadis.2018.01.005
NR 138
TC 7
Z9 8
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JAN 27
PY 2023
VL 9
AR 952159
DI 10.3389/fmed.2022.952159
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8T1NM
UT WOS:000929035500001
PM 36777160
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lohse, I
   Brothers, SP
AF Lohse, Ines
   Brothers, Shaun P.
TI Pathogenesis and Treatment of Pancreatic Cancer Related Pain
SO ANTICANCER RESEARCH
LA English
DT Review
DE Pancreatic cancer; pain; cancer treatment-induced pain; pancreatic
   cancer treatment; pancreatic cancer pain
ID CELIAC PLEXUS BLOCK; PERINEURAL INVASION; NEURAL INVASION; RISK;
   CHEMOTHERAPY; SURVIVAL; NEUROTOXICITY; HYPERALGESIA; INNERVATION;
   ACUPUNCTURE
AB Pancreatic cancer is often diagnosed due to the patient seeking medical attention for abdominal pain. It is among the most painful cancers, with pain severity strongly correlating with prognosis. Perineural invasion is a prominent feature of pancreatic cancer and often the first route of metastasis resulting in neuropathic pain. While surgical pain is present, it is generally short-lived; chemo- and radio-therapy associated side effect pain is often longer lasting and more difficult to manage. Treatment-induced mucositis in response to chemotherapy occurs throughout the GI tract resulting in infection-prone ulcers on the lip, buccal mucosa, palate or tongue. Cisplatin treatment is associated with axonal neuropathy in the dorsal root ganglion, although other large sensory fibers can be affected. Opioid-induced hyperalgesia can also emerge in patients. Along with traditional means to address pain, neurolytic celiac plexus block of afferent nociceptive fibers has been reported to be effective in 74% of patients. Moreover, as cancer treatments become more effective and result in improved survival, treatment-related side effects become more prevalent. Here, pancreatic cancer and treatment associated pain are reviewed along with current treatment strategies. Potential future therapeutic strategies to target the pathophysiology underlying pancreatic cancer and pain induction are also presented.
C1 [Lohse, Ines; Brothers, Shaun P.] Univ Miami, Miller Sch Med, Ctr Therapeut Innovat, Miami, FL 33136 USA.
   [Lohse, Ines; Brothers, Shaun P.] Univ Miami, Sylvester Comprehens Canc Ctr, Dept Psychiat & Behav Sci, Miami, FL USA.
   [Lohse, Ines; Brothers, Shaun P.] Univ Miami, Sylvester Comprehens Canc Ctr, Mol Therapeut Shared Resource, Miami, FL USA.
C3 University of Miami; University of Miami; University of Miami
RP Brothers, SP (corresponding author), Univ Miami, Miller Sch Med, Ctr Therapeut Innovat, Dept Psychiat & Behav Sci, 1501 NW 10th Ave,BRB 415, Miami, FL 33136 USA.
EM sbrothers@med.miami.edu
FU National Institutes of Health [R01NS092671, R01MH110441]; University of
   Miami Sylvester Comprehensive Cancer Center Molecular Therapeutics
   Shared Resource (MTSR); Jay Weiss Institute for Health Equity; Ryan
   Foundation; National Cancer Institute [P30CA240139] Funding Source: NIH
   RePORTER
FX SPB receives support from the National Institutes of Health (R01NS092671
   and R01MH110441), the University of Miami Sylvester Comprehensive Cancer
   Center Molecular Therapeutics Shared Resource (MTSR), the Jay Weiss
   Institute for Health Equity and the Ryan Foundation.
CR Abrams DI, 2016, CURR ONCOL, V23, pS8, DOI 10.3747/co.23.3099
   Allen PJ, 2011, ANN SURG ONCOL, V18, P636, DOI 10.1245/s10434-010-1372-x
   Alsamarrai A, 2014, CLIN GASTROENTEROL H, V12, P1635, DOI 10.1016/j.cgh.2014.01.038
   Alvarado S, 2015, FRONT CELL NEUROSCI, V9, DOI 10.3389/fncel.2015.00088
   Aprile G, 2015, WORLD J GASTROENTERO, V21, P11793, DOI 10.3748/wjg.v21.i41.11793
   Avritscher Elenir B C, 2004, Semin Oncol Nurs, V20, P3
   Bapat AA, 2011, NAT REV CANCER, V11, P695, DOI 10.1038/nrc3131
   Benyamin R, 2008, PAIN PHYSICIAN, V11, pS105
   Bertholet J, 2019, CLIN TRANSL RAD ONCO, V16, P21, DOI 10.1016/j.ctro.2019.03.001
   Boldrini L, 2019, RADIAT ONCOL, V14, DOI 10.1186/s13014-019-1275-3
   Bryant KL, 2020, NAT MED, V26, P982, DOI 10.1038/s41591-020-0947-8
   Carter GT, 2014, PHYS MED REH CLIN N, V25, P457, DOI 10.1016/j.pmr.2014.01.007
   Ceyhan GO, 2008, BIOCHEM BIOPH RES CO, V374, P442, DOI 10.1016/j.bbrc.2008.07.035
   Ceyhan GO, 2009, GASTROENTEROLOGY, V136, P177, DOI 10.1053/j.gastro.2008.09.029
   Chee NT, 2019, MOL CANCER, V18, DOI 10.1186/s12943-019-0968-4
   Chen H, 2013, PANCREATOLOGY, V13, P594, DOI 10.1016/j.pan.2013.10.007
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Collins MA, 2012, J CLIN INVEST, V122, P639, DOI 10.1172/JCI59227
   Colvin LA, 2019, PAIN, V160, pS1, DOI 10.1097/j.pain.0000000000001540
   Cornman-Homonoff J, 2017, SEMIN INTERVENT RAD, V34, P376, DOI 10.1055/s-0037-1608861
   D'Haese JG, 2014, WORLD J GASTROENTERO, V20, P9154, DOI 10.3748/wjg.v20.i27.9154
   Denk F, 2016, CELL REP, V15, P1771, DOI 10.1016/j.celrep.2016.04.063
   Denk F, 2014, NAT NEUROSCI, V17, P192, DOI 10.1038/nn.3628
   di Mola FF, 2008, LANGENBECK ARCH SURG, V393, P919, DOI 10.1007/s00423-007-0277-z
   Dobosz L, 2016, ANZ J SURG, V86, P756, DOI 10.1111/ans.13609
   Doehring A, 2011, EUR J PAIN, V15, P11, DOI 10.1016/j.ejpain.2010.06.004
   Donertas Basak, 2018, J Exp Pharmacol, V10, P19, DOI [10.2147/jep.s162059, 10.2147/JEP.S162059]
   Eibl G, 2005, PANCREAS, V31, P258, DOI 10.1097/01.mpa.0000175176.40045.0f
   Ernsting MJ, 2015, J CONTROL RELEASE, V206, P122, DOI 10.1016/j.jconrel.2015.03.023
   Fernandes R, 2016, SUPPORT CARE CANCER, V24, P1583, DOI 10.1007/s00520-015-2941-0
   Flak RV, 2019, SCAND J GASTROENTERO, V54, P252, DOI 10.1080/00365521.2019.1575465
   Furness JB, 2014, ADV EXP MED BIOL, V817, P39, DOI 10.1007/978-1-4939-0897-4_3
   Gamelin L, 2004, CLIN CANCER RES, V10, P4055, DOI 10.1158/1078-0432.CCR-03-0666
   Gil Z, 2010, J NATL CANCER I, V102, P107, DOI 10.1093/jnci/djp456
   Gill P, 2019, ENDOCR PATHOL
   Gunduz OH, 2017, J PAIN RES, V10, P2815, DOI 10.2147/JPR.S134775
   Gurbuz N, 2019, ANTICANCER RES, V39, P529, DOI 10.21873/anticanres.13144
   Hameed Mariam, 2010, Cancers (Basel), V3, P43, DOI 10.3390/cancers3010043
   Haney SL, 2019, ONCOGENE, V38, P5308, DOI 10.1038/s41388-019-0794-6
   Hanks GW, 2001, BRIT J CANCER, V84, P587, DOI 10.1054/bjoc.2001.1680
   Harirforoosh S, 2013, J PHARM PHARM SCI, V16, P821, DOI 10.18433/J3VW2F
   Harris Debra J, 2006, Ther Clin Risk Manag, V2, P251, DOI 10.2147/tcrm.2006.2.3.251
   Harris DG, 2014, BRIT MED BULL, V110, P117, DOI 10.1093/bmb/ldu010
   JEMAL A, 2011, CA-CANCER J CLIN, V61, P134, DOI DOI 10.3322/caac.20115
   Jiao L, 2009, ARCH INTERN MED, V169, P764, DOI 10.1001/archinternmed.2009.46
   Jing WQ, 2019, J IMMUNOTHER CANCER, V7, DOI 10.1186/s40425-019-0573-5
   Kanat O, 2017, WORLD J CLIN ONCOL, V8, P329, DOI 10.5306/wjco.v8.i4.329
   Kapral M, 2017, MOLECULES, V22, DOI 10.3390/molecules22101657
   Katsuda M, 2019, TRIALS, V20, DOI 10.1186/s13063-019-3332-5
   Kirkegård J, 2017, AM J GASTROENTEROL, V112, P1366, DOI 10.1038/ajg.2017.218
   Larsson SC, 2005, BRIT J CANCER, V93, P1310, DOI 10.1038/sj.bjc.6602868
   Lindsay TH, 2005, PAIN, V119, P233, DOI 10.1016/j.pain.2005.10.019
   Liu Y, 2019, ONCOL REP, V41, P1521, DOI 10.3892/or.2019.6979
   Lohse I, 2017, ONCOTARGET, V8, P3064, DOI 10.18632/oncotarget.13619
   Lohse I, 2015, BRIT J CANCER, V113, P425, DOI 10.1038/bjc.2015.220
   Lohse Ines, 2018, Oncotarget, V9, P35448, DOI [10.18632/oncotarget.26234, 10.18632/oncotarget.26234]
   Lohse I, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0167272
   Lohse I, 2016, ONCOTARGET, V7, P33571, DOI 10.18632/oncotarget.9654
   Lohse I, 2014, CANCERS, V6, P459, DOI 10.3390/cancers6010459
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Malsy M, 2019, BMC BIOCHEM, V20, DOI 10.1186/s12858-019-0105-4
   Matsushita Y, 2013, BRIT J PHARMACOL, V170, P991, DOI 10.1111/bph.12366
   McCarthy MW, 2018, EXPERT REV ANTI-INFE, V16, P849, DOI 10.1080/14787210.2018.1536546
   Mercadante S, 2003, J PAIN SYMPTOM MANAG, V26, P1140, DOI 10.1016/j.jpainsymman.2003.04.004
   MERCADANTE S, 1993, PAIN, V52, P187, DOI 10.1016/0304-3959(93)90130-H
   Meyer L, 2010, CELL MOL LIFE SCI, V67, P3017, DOI 10.1007/s00018-010-0372-0
   Montgomery GH, 2013, CA-CANCER J CLIN, V63, P31, DOI 10.3322/caac.21165
   Müller MW, 2008, AM J SURG, V195, P221, DOI 10.1016/j.amjsurg.2007.02.026
   Murakawa M, 2019, J CANCER, V10, P627, DOI 10.7150/jca.28660
   Niederberger E, 2017, NAT REV NEUROL, V13, P434, DOI 10.1038/nrneurol.2017.68
   Nienhuijs SW, 2012, PANCREAS, V41, P1063, DOI 10.1097/MPA.0b013e31824c3dbf
   Niu LZ, 2013, CRYOBIOLOGY, V66, P105, DOI 10.1016/j.cryobiol.2012.12.002
   Obazee O, 2019, INT J CANCER, V145, P686, DOI 10.1002/ijc.32127
   Oronsky B, 2018, TRANSL ONCOL, V11, P771, DOI 10.1016/j.tranon.2018.03.014
   Paulson AS, 2013, GASTROENTEROLOGY, V144, P1316, DOI 10.1053/j.gastro.2013.01.078
   Pei YY, 2019, SMALL, V15, DOI 10.1002/smll.201900631
   Pour PM, 2003, PANCREAS, V26, P322, DOI 10.1097/00006676-200305000-00002
   Ray P, 2019, J CELL COMMUN SIGNAL
   Rodríguez-Caballero A, 2012, INT J ORAL MAX SURG, V41, P225, DOI 10.1016/j.ijom.2011.10.011
   Roeckel LA, 2016, NEUROSCIENCE, V338, P160, DOI 10.1016/j.neuroscience.2016.06.029
   Seicean A, 2014, WORLD J GASTROENTERO, V20, P110, DOI 10.3748/wjg.v20.i1.110
   Seufferlein T, 2012, ANN ONCOL, V23, P33, DOI 10.1093/annonc/mds224
   Singhal M, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0211711
   Sisignano M, 2019, NAT REV NEUROL, V10, P694
   Thibodeau ML, 2019, CSH MOL CASE STUD, V5, DOI 10.1101/mcs.a003681
   van Mackelenbergh MG, 2019, CANCERS, V11, DOI 10.3390/cancers11050588
   Varrassi G, 2018, PAIN THER, V7, P59, DOI 10.1007/s40122-018-0094-9
   Wawszczyk J, 2015, ACTA POL PHARM, V72, P895
   Wolfgang CL, 2013, CA-CANCER J CLIN, V63, P318, DOI 10.3322/caac.21190
   Wong GY, 2004, JAMA-J AM MED ASSOC, V291, P1092, DOI 10.1001/jama.291.9.1092
   Wood LD, 2019, GASTROENTEROLOGY
   Wu J, 2019, J ENZYM INHIB MED CH, V34, P420, DOI 10.1080/14756366.2018.1484734
   Zheng JL, 2017, NUTR REV, V75, P883, DOI 10.1093/nutrit/nux038
NR 93
TC 57
Z9 70
U1 7
U2 56
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0250-7005
EI 1791-7530
J9 ANTICANCER RES
JI Anticancer Res.
PD APR
PY 2020
VL 40
IS 4
BP 1789
EP 1796
DI 10.21873/anticanres.14133
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA KY7DO
UT WOS:000522734400001
PM 32234867
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Guo, X
   Zhao, YY
   Huang, F
   Li, SY
   Luo, M
   Wang, Y
   Zhang, JL
   Li, L
   Zhang, Y
   Jiao, Y
   Zhao, B
   Wang, JY
   Meng, H
   Zhang, ZJ
   Rong, PJ
AF Guo, Xiao
   Zhao, Yuanyuan
   Huang, Feng
   Li, Shaoyuan
   Luo, Man
   Wang, Yu
   Zhang, Jinling
   Li, Liang
   Zhang, Yue
   Jiao, Yue
   Zhao, Bin
   Wang, Junying
   Meng, Hong
   Zhang, Zhangjin
   Rong, Peijing
TI Effects of Transcutaneous Auricular Vagus Nerve Stimulation on
   Peripheral and Central Tumor Necrosis Factor Alpha in Rats with
   Depression-Chronic Somatic Pain Comorbidity
SO NEURAL PLASTICITY
LA English
DT Article
ID CHOLINERGIC ANTIINFLAMMATORY PATHWAY; NEUROPATHIC PAIN; SUBSTANCE-P;
   NEUROPEPTIDE; INVOLVEMENT; DYSFUNCTION; MECHANISMS; BEHAVIOR
AB Depression and pain disorders share a high degree of comorbidity. Inflammatory mechanisms play an important role in the pathogenesis of depression-chronic somatic pain comorbidity. In this study, we investigated the effects of acupuncture on blood and brain regional tumor necrosis factor alpha (TNF-alpha) in rats with depression and chronic somatic pain comorbidity. Forty Sprague-Dawley rats were randomly divided into the following 4 groups with 10 each: control, model, model treated with transcutaneous auricular vagus nerve stimulation (taVNS), and model treated with electroacupuncture (EA). Chronic unpredictable mild stress (CUMS) with chronic constriction injury of the sciatic nerve (CCI) was used to produce depression and chronic somatic pain comorbidity in the latter 3 groups. The rats of the taVNS and EA groups received, respectively, taVNS and EA at ST 36 for 28 days. Pain intensity was measured using a mechanical withdrawal threshold and thermal stimulation latency once biweekly. Depressive behavior was examined using a sucrose preference test at baseline and the end of modeling and intervention. The level of plasma TNF-alpha and the expression of TNF-alpha in the prefrontal cortex (PFC), hippocampus, amygdala, and hypothalamus were measured. While CUMS plus CCI produced remarkable depression-like behavior and pain disorders, EA and taVNS significantly improved depression and reduced pain intensity. CUMS plus CCI also resulted in a significant increase in plasma TNF-alpha level and the expression in all brain regions examined compared to the intact controls. Both EA and taVNS interventions, however, suppressed the elevated level of TNF-alpha. These results suggest that EA and taVNS have antidepressant and analgesic effects. Such effects may be associated with the suppression of TNF-alpha-related neuroinflammation.
C1 [Guo, Xiao; Huang, Feng; Li, Shaoyuan; Luo, Man; Wang, Yu; Zhang, Jinling; Li, Liang; Zhang, Yue; Jiao, Yue; Zhao, Bin; Wang, Junying; Rong, Peijing] China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Beijing 100700, Peoples R China.
   [Guo, Xiao] China Acad Chinese Med Sci, Dept Sci Res Management, Beijing 100700, Peoples R China.
   [Zhao, Yuanyuan] Hebei Med Univ, Dept Psychiat, Hosp 1, Shijiazhuang 050031, Hebei, Peoples R China.
   [Huang, Feng] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing 100010, Peoples R China.
   [Meng, Hong] Beijing Technol & Business Univ, Key Lab Cosmet, China Natl Light Ind, Beijing 100048, Peoples R China.
   [Zhang, Zhangjin] Univ Hong Kong, LKS Fac Med, Sch Chinese Med, Hong Kong, Peoples R China.
C3 Institute of Acupuncture & Moxibustion, CACMS; China Academy of Chinese
   Medical Sciences; China Academy of Chinese Medical Sciences; Hebei
   Medical University; Capital Medical University; Beijing Technology &
   Business University; University of Hong Kong
RP Rong, PJ (corresponding author), China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Beijing 100700, Peoples R China.; Zhang, ZJ (corresponding author), Univ Hong Kong, LKS Fac Med, Sch Chinese Med, Hong Kong, Peoples R China.
EM zhangzj@hku.hk; drrongpj@163.com
RI ZHANG, ZHANG-JIN/ORK-0709-2025; Wang, Yu/KZU-7684-2024; Wang,
   Junying/OHV-2884-2025; Guo, Xiaoyuan/AAP-1101-2021
OI Wang, Yu/0000-0001-5070-0038; Zhang, Jinling/0000-0001-8186-5919; 
FU National Basic Research Program of China [2018YFC1705800]; International
   Cooperation Project of Traditional Chinese Medicine in China Academy of
   Chinese Medical Sciences [GH2017-07]; Guangdong Province Higher
   Vocational Colleges and Schools Pearl River Scholar Funded Scheme (2018)
   [A1-AFD018181Z3905]; Beijing Key Laboratory of Plant Resources Research
   and Development; Beijing Technology and Business University Innovation
   [PRRD-2016-ZD2]; Fundamental Research Funds for Beijing Municipal
   Science & Technology Commission [Z161100002616003]; Joint Sino-German
   Research Project [GZ1236]
FX This work was supported by the National Basic Research Program of China
   (2018YFC1705800), International Cooperation Project of Traditional
   Chinese Medicine in China Academy of Chinese Medical Sciences
   (GH2017-07), Guangdong Province Higher Vocational Colleges and Schools
   Pearl River Scholar Funded Scheme (2018) (A1-AFD018181Z3905), Beijing
   Key Laboratory of Plant Resources Research and Development, Beijing
   Technology and Business University Innovation (PRRD-2016-ZD2),
   Fundamental Research Funds for Beijing Municipal Science & Technology
   Commission (Z161100002616003), and Joint Sino-German Research Project
   (GZ1236).
CR [Anonymous], 2013, THESIS
   Bortolato B, 2015, CURR NEUROPHARMACOL, V13, P558, DOI 10.2174/1570159X13666150630171433
   Bravo L, 2012, ANESTHESIOLOGY, V117, P613, DOI 10.1097/ALN.0b013e3182657b3e
   Burke NN, 2015, MOD TR PHARMACOPSYCH, V30, P36, DOI 10.1159/000435931
   Burke NN, 2015, BEHAV BRAIN RES, V278, P193, DOI 10.1016/j.bbr.2014.09.044
   Cao BY, 2016, J TRADIT CHIN MED, V36, P768
   Chang CT, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071596
   Doan L, 2015, NEURAL PLAST, V2015, DOI 10.1155/2015/504691
   Du JY, 2017, NEURAL PLAST, V2017, DOI 10.1155/2017/3728752
   Felger JC, 2013, NEUROSCIENCE, V246, P199, DOI 10.1016/j.neuroscience.2013.04.060
   Fishbain DA, 2014, PAIN MED, V15, P1522, DOI 10.1111/pme.12448
   Gao Yong-Hui, 2018, Zhen Ci Yan Jiu, V43, P537, DOI 10.13702/j.1000-0607.170450
   Geng Y, 2017, EVID-BASED COMPL ALT, V2017
   Hsu HC, 2014, SCI WORLD J, DOI 10.1155/2014/129875
   Johnson MB, 2017, FRONT CELL NEUROSCI, V10, DOI 10.3389/fncel.2016.00296
   Kong J, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00020
   Kox M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034431
   Liang Hai-xia, 2008, Chinese Pharmacological Bulletin, V24, P555
   Lin CH, 2014, J AFFECT DISORDERS, V166, P173, DOI 10.1016/j.jad.2014.03.039
   Liu D, 2018, ARTHRITIS RES THER, V20, DOI 10.1186/s13075-018-1759-9
   Lu XX, 2017, MED SCI MONITOR, V23, P6072, DOI 10.12659/MSM.907628
   Mashaghi A, 2016, CELL MOL LIFE SCI, V73, P4249, DOI 10.1007/s00018-016-2293-z
   Rijavec N, 2012, PSYCHIAT DANUB, V24, P346
   [荣培晶 Rong Peijing], 2019, [中医杂志, Journal of Traditional Chinese Medicine], V60, P295
   Sheng JY, 2017, NEURAL PLAST, V2017, DOI 10.1155/2017/9724371
   Shiozawa P, 2014, ARQ NEURO-PSIQUIAT, V72, P542
   Song Q, 2014, AFR J TRADIT COMPLEM, V11, P469, DOI 10.4314/ajtcam.v11i2.35
   Sun H., 2003, J CLIN ACUPUNCTURE M, V19, P47
   Sun Hua, 2010, Zhongguo Zhen Jiu, V30, P195
   Suvas S, 2017, J IMMUNOL, V199, P1543, DOI 10.4049/jimmunol.1601751
   Tu YH, 2018, BRAIN STIMUL, V11, P501, DOI 10.1016/j.brs.2018.01.006
   Walker AK, 2014, PHARMACOL REV, V66, P80, DOI 10.1124/pr.113.008144
   Wang H, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/787393
   Wang ZJ, 2018, J PSYCHIATR RES, V102, P123, DOI 10.1016/j.jpsychires.2017.12.018
   Wu YY, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/732845
   Yang M., 2013, J NANCHANG U, V53, P80
   Yang XH, 2017, NEUROPSYCH DIS TREAT, V13, P2727, DOI 10.2147/NDT.S150028
   [俞裕天 Yu Yutian], 2017, [世界科学技术：中医药现代化, Modernization of Traditional Chinese Medicine and Materia Medica--World Science and Technology], V19, P462
   Zhao GM, 2015, YIXUE ZONGSHU, V21, P2890
   Zhao YX, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/627023
   Zhou DP, 2018, VIRULENCE, V9, P1364, DOI 10.1080/21505594.2018.1482179
NR 41
TC 38
Z9 43
U1 2
U2 29
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-5904
EI 1687-5443
J9 NEURAL PLAST
JI Neural. Plast.
PD OCT 22
PY 2020
VL 2020
AR 8885729
DI 10.1155/2020/8885729
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA OU6JL
UT WOS:000591632700001
PM 33144854
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Kong, C
   Han, MF
   Zhang, CP
   Zhao, ZB
   Fang, FF
   Zhang, Z
   Huang, F
   Luan, XW
   Li, B
AF Kong, Chen
   Han, Mengfei
   Zhang, Chunpeng
   Zhao, Zhibin
   Fang, Fanfu
   Zhang, Zhan
   Huang, Feng
   Luan, Xiaowei
   Li, Bai
TI Auricular point acupressure improved nausea, vomiting, diarrhea and
   nutritional status in gastric cancer patients receiving oral S-1.
   therapy
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Auricular point acupressure; chemotherapy; nausea; vomiting; diarrhea;
   nutrition
ID LOW-BACK-PAIN; ACUPUNCTURE; CHEMOTHERAPY; FATIGUE; TRIAL
AB Objective: This study explored the efficacy of auricular point acupressure (APA) on controlling gastrointestinal dysfunction and improving nutritional status in gastric cancer patients receiving oral S-1 treatments. Methods: One-hundred and ten gastric cancer patients who received oral S-1 therapy were enrolled and randomized into two sub-cohorts (1:1). In the experimental sub-cohort, specific auricular points were stimulated to control nausea, vomiting, and diarrhea, including the shenmen, cardia, stomach, sympathetic, digestive subcortex, liver, and spleen. The auricular points that were stimulated in the control cohort included the eye, wrist, toe, and external genitals. Patients wore auricular seeds for 21 days and recorded instances of nausea, vomiting, and diarrhea using the National Cancer Institute common toxicity criteria as benchmarks. Weight, height, total blood protein, and albumin levels were measured twice per patient at the start and end of the experimental course. Results: Incidence rates of nausea, vomiting, and diarrhea were similar between the two sub-cohorts (p>0.05). Patients in the experimental sub-cohort experienced lower severities and shorter durations of nausea, vomiting, and diarrhea when compared to controls (p<0.05). Additionally, patients in the experimental sub-cohort experienced less dramatic reductions in nutrition indices, including body weight, body mass index, total blood protein, and albumin levels (p<0.05). Conclusions: The data presented here indicate that APA treatment decreased the severity and duration of nausea, vomiting and diarrhea in gastric cancer patients receiving oral S-1 chemotherapy. This treatment may improve the nutritional status of treated patients. However, incidence rates of S-1 treatment-related side effects were unaltered by APA.
C1 [Kong, Chen; Han, Mengfei; Zhang, Chunpeng; Fang, Fanfu; Zhang, Zhan; Huang, Feng; Luan, Xiaowei; Li, Bai] Second Mil Med Univ, Changhai Hosp Tradit Chinese Med, Dept Rehabil Med, Shanghai, Peoples R China.
   [Zhao, Zhibin] Second Mil Med Univ, Changhai Hosp Tradit Chinese Med, Dept Acupuncture & Moxibust, Shanghai, Peoples R China.
   [Kong, Chen] New Jiangwan City Community Hlth Serv Ctr, Dept Tradit Chinese Med, Shanghai, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Li, B (corresponding author), Dept Rehabil Med, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM yadianna560@126.com
RI li, bai/GRJ-4913-2022; Zhao, Zhibin/KIJ-6474-2024
CR [Anonymous], 1990, Report of the Working Group on Auricular Acupuncture Nomenclature
   [Anonymous], 2005, Auricular Medicine: A Complete Manual of Auricular Diagnosis and Treatment
   [Anonymous], HDB AURICULAR TREATM
   Cherkin DC, 2001, ARCH INTERN MED, V161, P1081, DOI 10.1001/archinte.161.8.1081
   Earle CC, 1999, EUR J CANCER, V35, P1059, DOI 10.1016/S0959-8049(99)00076-3
   Gallo A, 2006, WORLD J GASTROENTERO, V12, P3237, DOI 10.3748/wjg.v12.i20.3237
   Gunderson LL, 2002, SEMIN RADIAT ONCOL, V12, P150, DOI 10.1053/srao.2002.30817
   Herr I, 2003, CANCER RES, V63, P3112
   Hong YS, 2012, LANCET ONCOL, V13, P1125, DOI 10.1016/S1470-2045(12)70363-7
   Huang YK, 2015, WORLD J GASTROENTERO, V21, P9863, DOI 10.3748/wjg.v21.i34.9863
   Jemal A, 2010, CA-CANCER J CLIN, V60, P277, DOI [10.3322/caac.20073, 10.3322/caac.21254]
   Kilic L, 2016, WORLD J GASTRO ONCOL, V8, P439, DOI 10.4251/wjgo.v8.i5.439
   Nogier P., 1981, HDB AURICULOTHERAPY
   Oleson T., 2003, Auriculotherapy Manual Chinese and Western Systems of Ear Acupuncture, V3rd
   Reindl TK, 2006, SUPPORT CARE CANCER, V14, P172, DOI 10.1007/s00520-005-0846-z
   Schneider S, 2011, J PAIN, V12, P228, DOI 10.1016/j.jpain.2010.07.001
   Sorbi MJ, 2006, CLIN J PAIN, V22, P55, DOI 10.1097/01.ajp.0000148624.46756.fa
   Stone AA, 2003, CONTROL CLIN TRIALS, V24, P182, DOI 10.1016/S0197-2456(02)00320-3
   Yang L, 2015, ONCOL LETT, V9, P1451, DOI 10.3892/ol.2014.2821
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Yeh CH, 2015, PAIN MED, V16, P1857, DOI 10.1111/pme.12789
   Yeh CH, 2015, PAIN MANAG NURS, V16, P285, DOI 10.1016/j.pmn.2014.08.005
   Yeh CH, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/375173
   Yeh CH, 2014, HOLIST NURS PRACT, V28, P184, DOI 10.1097/HNP.0000000000000027
   Yeh CH, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/196978
   Yeh CH, 2012, J ALTERN COMPLEM MED, V18, P334, DOI 10.1089/acm.2011.0102
   Yeh CH, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/383257
   Yuan J, 2008, SPINE, V33, pE887, DOI 10.1097/BRS.0b013e318186b276
NR 28
TC 6
Z9 6
U1 1
U2 19
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2018
VL 11
IS 9
BP 9200
EP 9209
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GY8AL
UT WOS:000448839700036
DA 2026-01-16
ER

PT J
AU Zhi, WI
   Gentile, D
   Diller, M
   Kinney, A
   Bao, T
   Master, V
   Wang, XS
AF Zhi, W. Iris
   Gentile, Danielle
   Diller, Maggie
   Kinney, Anita
   Bao, Ting
   Master, Viraj
   Wang, Xin Shelley
TI Patient-Reported Outcomes of Pain and Related Symptoms in Integrative
   Oncology Practice and Clinical Research: Evidence and Recommendations
SO ONCOLOGY-NEW YORK
LA English
DT Review
AB Pain is a primary concern among patients with cancer and cancer survivors. Integrative interventions such as acupuncture, massage, and music therapy are effective nonpharmacologic approaches for cancer pain with low cost and minimal adverse events. Patient-reported outcomes (PROs) that have been validated in many clinical and research settings can be used to evaluate pain intensity, associated symptom burden, and quality of life. Clearly defined, reliable PROs can improve patient satisfaction and symptom control. As integrative oncology continues to evolve and expand, cancer-related pain PROs must be standardized to accurately guide clinicians and researchers. Well-validated pain PROs, such as the Brief Pain Inventory, are among the most commonly used for pain intensity assessment. Multiple symptom assessment tools such as the MD Anderson Symptom Inventory, the Memorial Symptom Assessment Scale, the Edmonton Symptom Assessment System, and the Patient-Reported Outcomes-Common Terminology Criteria for Adverse Events measurement system can also capture pain-associated symptom burden. Electronic PROs provide flexibility in collecting and analyzing PRO data. Clinical trials using carefully selected PROs and rigorous statistical analysis plans are fundamental to conducting high-quality integrative oncology research and promoting utilization of effective integrative interventions to improve patient outcomes. In this review, we aim to summarize current, validated PROs specific to cancer-related pain to aid integrative oncology clinicians and researchers in patient care and in study design and implementation.
C1 [Zhi, W. Iris] Mem Sloan Kettering Canc Ctr, Solid Tumor Div, Breast Med Serv, 1275 York Ave, New York, NY 10021 USA.
   [Gentile, Danielle] Levine Canc Inst, Dept Support Oncol, Med, Charlotte, NC USA.
   [Diller, Maggie] Emory Univ, Winship Canc Inst, Dept Surg, Atlanta, GA 30322 USA.
   [Kinney, Anita] Sch Publ Hlth, Dept Biostat & Epidemiol, New Brunswick, NJ USA.
   [Kinney, Anita] Rutgers Canc Inst New Jersey, New Brunswick, NJ USA.
   [Bao, Ting] Mem Sloan Kettering Canc Ctr, Integrat Breast Oncol Integrat Med & Breast Med S, 1275 York Ave, New York, NY 10021 USA.
   [Wang, Xin Shelley] Univ Texas MD Anderson Canc Ctr, Dept Symptom Res, Houston, TX 77030 USA.
   [Master, Viraj] Emory Univ, Sch Med, Winship Canc Inst, Integrat Oncol & Survivorship, Atlanta, GA 30322 USA.
C3 Memorial Sloan Kettering Cancer Center; Emory University; Rutgers
   University System; Rutgers University New Brunswick; Rutgers University
   Biomedical & Health Sciences; Rutgers Cancer Institute of New Jersey;
   Memorial Sloan Kettering Cancer Center; University of Texas System; UTMD
   Anderson Cancer Center; Emory University
RP Zhi, WI (corresponding author), Mem Sloan Kettering Canc Ctr, Solid Tumor Div, Breast Med Serv, 1275 York Ave, New York, NY 10021 USA.
RI ; Gentile, Danielle/L-5733-2019
OI Kinney, Anita/0000-0002-2996-9355; Zhi, Iris/0000-0003-4263-7272
CR Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Cleeland C S, 1987, Oncology (Williston Park), V1, P19
   Cleeland CS, 2013, CANCER-AM CANCER SOC, V119, P4333, DOI 10.1002/cncr.28376
   Deandrea S, 2008, ANN ONCOL, V19, P1985, DOI 10.1093/annonc/mdn419
   Dowell Deborah, 2016, JAMA, V315, P1624, DOI [10.15585/mmwr.rr6501e1, 10.1001/jama.2016.1464]
   Everdingen MHJVDBV, 2007, ANN ONCOL, V18, P1437, DOI 10.1093/annonc/mdm056
   Gallagher LM, 2018, AM J HOSP PALLIAT ME, V35, P250, DOI 10.1177/1049909117696723
   Inst Med, 2011, RELIEVING PAIN IN AMERICA: A BLUEPRINT FOR TRANSFORMING PREVENTION, CARE, EDUCATION, AND RESEARCH, P1
   Jemal A, 2020, CA-CANCER J CLIN, V70, P7, DOI 10.3322/caac.21590
   Lee SH, 2015, INTEGR CANCER THER, V14, P297, DOI 10.1177/1534735415572885
   Miller KD, 2019, CA-CANCER J CLIN, V69, P363, DOI 10.3322/caac.21565
   Oldenmenger WH, 2009, EUR J CANCER, V45, P1370, DOI 10.1016/j.ejca.2009.01.007
   Paice JA, 2016, J CLIN ONCOL, V34, P3325, DOI 10.1200/JCO.2016.68.5206
   Porta-Sales J, 2015, J PALLIAT MED, V18, P923, DOI 10.1089/jpm.2015.29002.jps
   van den Beuken-van Everdingen MHJ, 2016, J PAIN SYMPTOM MANAG, V51, P1070, DOI 10.1016/j.jpainsymman.2015.12.340
NR 15
TC 16
Z9 18
U1 1
U2 17
PU UBM MEDICA
PI NORWALK
PA 535 CONNECTICUT AVE, STE 300, NORWALK, CT 06854 USA
SN 0890-9091
EI 2767-7389
J9 ONCOLOGY-NY
JI Oncology-NY
PD JAN
PY 2021
VL 35
IS 1
BP 35
EP 41
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA PT5XQ
UT WOS:000608688400012
PM 33443769
DA 2026-01-16
ER

PT J
AU Bell, A
   Helm, J
   Reid, J
AF Bell, A.
   Helm, J.
   Reid, J.
TI Veterinarians' attitudes to chronic pain in dogs
SO VETERINARY RECORD
LA English
DT Article
ID QUALITY-OF-LIFE; APPENDICULAR OSTEOSARCOMA; ANTIINFLAMMATORY DRUGS;
   NEUROPATHIC PAIN; QUESTIONNAIRE; PHARMACOKINETICS; ACUPUNCTURE;
   VALIDATION; ANALGESIA; MORPHINE
AB Veterinary surgeons in the UK were invited to complete an internet survey concerning their attitudes to chronic pain in dogs. UK veterinary surgeons numbering 215 completed surveys in full along with 48 worldwide specialists in anaesthesia and 37 worldwide specialists in oncology. Osteoarthritis, dental and aural disease, vertebral and spinal cord conditions, neoplasia and skin conditions were considered important causes of chronic pain in dogs. UK practitioners used significantly fewer classes of analgesic drugs regularly than either category of specialist. The major barriers to adequate treatment of chronic pain were reported as difficulties with pain assessment, expense of drugs, and difficulties with owner compliance. Illustrations of six common neoplastic conditions were used and scored for pain according to prior experience by practitioners. All six conditions were consistently described as involving some degree of pain with primary bone tumour and oral tumour, causing severe pain and moderate to severe pain, respectively. Years since graduation and specialist status affected the pain scores attributed to the conditions. There was a significant correlation between the pain score attributed to the illustrated condition, and the tendency to administer analgesia.
C1 [Bell, A.; Helm, J.; Reid, J.] Univ Glasgow, Sch Vet Med, Glasgow G61 1QH, Lanark, Scotland.
C3 University of Glasgow
RP Bell, A (corresponding author), Univ Glasgow, Sch Vet Med, Glasgow G61 1QH, Lanark, Scotland.
EM Andrew.bell@glasgow.ac.uk
OI Bell, Anew/0000-0001-6510-4423
FU Boehringer Ingelheim
FX The authors would like to thank all the veterinary surgeons who took the
   time to complete the survey, and Boehringer Ingelheim for their generous
   support with the costs of the study.
CR Adams VJ, 2005, JAVMA-J AM VET MED A, V226, P567, DOI 10.2460/javma.2005.226.567
   Beckman BW, 2006, J VET DENT, V23, P50, DOI 10.1177/089875640602300110
   Bound NJ, 2011, VET REC, V168, DOI 10.1136/vr.d1021
   Breivik H, 2008, BRIT J ANAESTH, V101, P17, DOI 10.1093/bja/aen103
   Brown DC, 2008, JAVMA-J AM VET MED A, V233, P1278, DOI 10.2460/javma.233.8.1278
   Brown DC, 2009, PAIN MED, V10, P133, DOI 10.1111/j.1526-4637.2008.00513.x
   Capner CA, 1999, VET REC, V145, P95
   Chen Lucy, 2011, J Opioid Manag, V7, P267
   Chew DJ, 1998, J AM VET MED ASSOC, V213, P1282
   Colvin LA, 2008, BRIT J ANAESTH, V101, P1, DOI 10.1093/bja/aen120
   Dobson JM, 2002, J SMALL ANIM PRACT, V43, P240, DOI 10.1111/j.1748-5827.2002.tb00066.x
   Fan TM, 2007, J VET INTERN MED, V21, P431, DOI 10.1892/0891-6640(2007)21[431:SPFPTO]2.0.CO;2
   Fleming JM, 2011, J VET INTERN MED, V25, P187, DOI 10.1111/j.1939-1676.2011.0695.x
   Flôr PB, 2013, VET ANAESTH ANALG, V40, P316, DOI 10.1111/vaa.12023
   Fox S M., 2010, Chronic Pain in Small Animal Medicine, P74
   Fox SM, 2012, VET CLIN N AM-SMALL, V42, P727, DOI 10.1016/j.cvsm.2012.04.010
   Giorgi M, 2009, VET RES COMMUN, V33, P875, DOI 10.1007/s11259-009-9236-1
   Habacher G, 2006, J VET INTERN MED, V20, P480, DOI 10.1892/0891-6640(2006)20[480:EOAIVM]2.0.CO;2
   Hielm-Björkman AK, 2009, AM J VET RES, V70, P727, DOI 10.2460/ajvr.70.6.727
   Hunter JEB, 2010, VET REC, V167, P947, DOI 10.1136/vr.c7045
   Innes JF, 2010, VET REC, V166, P226, DOI 10.1136/vr.c97
   Johnston SA, 1997, VET CLIN N AM-SMALL, V27, P699, DOI 10.1016/S0195-5616(97)50076-3
   Kong VKF, 2007, BRIT J ANAESTH, V99, P775, DOI 10.1093/bja/aem316
   KuKanich B, 2005, J VET PHARMACOL THER, V28, P461, DOI 10.1111/j.1365-2885.2005.00681.x
   Kukanich B, 2005, J VET PHARMACOL THER, V28, P371, DOI 10.1111/j.1365-2885.2005.00661.x
   KuKanich B, 2004, J VET PHARMACOL THER, V27, P239, DOI 10.1111/j.1365-2885.2004.00578.x
   KuKanich B, 2010, J VET PHARMACOL THER, V33, P15, DOI 10.1111/j.1365-2885.2009.01098.x
   KuKanich B, 2012, VET ANAESTH ANALG, V39, P69, DOI 10.1111/j.1467-2995.2011.00675.x
   Lascelles BDX, 2008, J VET INTERN MED, V22, P53, DOI 10.1111/j.1939-1676.2007.0014.x
   LASCELLES B. D. X., 2012, WITHROW MACEWENS SMA, P245
   Lascelles BDX, 1999, VET REC, V145, P601, DOI 10.1136/vr.145.21.601
   Lindley S, 2006, IN PRACTICE, V28, P544, DOI 10.1136/inpract.28.9.544
   Looney A, 2010, TOP COMPANION ANIM M, V25, P32, DOI 10.1053/j.tcam.2009.10.008
   Lund EM, 1999, J AM VET MED ASSOC, V214, P1336
   Malek S, 2012, BMC VET RES, V8, DOI 10.1186/1746-6148-8-185
   Mathews KA, 2008, VET CLIN N AM-SMALL, V38, P1365, DOI 10.1016/j.cvsm.2008.09.001
   [Merskey H. IASP. IASP.], 1994, IASP Task Force on Taxonomy, VSecond
   Mölsä SH, 2013, JAVMA-J AM VET MED A, V243, P689, DOI 10.2460/javma.243.5.689
   Platt S., 2013, BSAVA manual of canine and feline neurology, V4a, P252
   Raekallio M, 2003, VET J, V165, P131, DOI 10.1016/S1090-0233(02)00186-7
   Ramirez O III, 1999, VET RADIOL ULTRASOUN, V40, P517, DOI 10.1111/j.1740-8261.1999.tb00385.x
   Reid J, 2013, J SMALL ANIM PRACT, V54, P227, DOI 10.1111/jsap.12059
   Reid J, 2013, IN PRACTICE, V35, P51, DOI 10.1136/inp.f631
   Rusbridge C, 2008, VET J, V175, P164, DOI 10.1016/j.tvjl.2006.12.007
   Sasamura T, 2002, EUR J PHARMACOL, V441, P185, DOI 10.1016/S0014-2999(02)01450-4
   Sessler DI, 2008, CONTEMP CLIN TRIALS, V29, P517, DOI 10.1016/j.cct.2008.01.002
   Wiseman-Orr ML, 2006, AM J VET RES, V67, P1826, DOI 10.2460/ajvr.67.11.1826
   Wiseman-Orr ML, 2004, AM J VET RES, V65, P1077, DOI 10.2460/ajvr.2004.65.1077
   Xellyerw P, 2007, J AM ANIM HOSP ASSOC, V43, P235, DOI 10.5326/0430235
   Yazbek KVB, 2005, JAVMA-J AM VET MED A, V226, P1354, DOI 10.2460/javma.2005.226.1354
NR 50
TC 32
Z9 35
U1 1
U2 60
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0042-4900
EI 2042-7670
J9 VET REC
JI Vet. Rec.
PD NOV 1
PY 2014
VL 175
IS 17
DI 10.1136/vr.102352
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA AS2DH
UT WOS:000344089100015
PM 25028465
DA 2026-01-16
ER

PT J
AU Rahman, A
   Rahman, R
   Macrinici, G
   Li, S
AF Rahman, Abed
   Rahman, Raed
   Macrinici, George
   Li, Sam
TI Low Volume Neurolytic Retrocrural Celiac Plexus Block for Visceral
   Cancer Pain: Retrospective Review of 507 Patients with Severe Malignancy
   Related Pain Due to Primary Abdominal Cancer or Metastatic Disease
SO PAIN PHYSICIAN
LA English
DT Review
DE Celiac plexus; neurolytic; abdominal cancer pain; pain; retrocrural;
   cancer pain
ID SPLANCHNIC NERVE NEUROLYSIS; QUALITY-OF-LIFE; PANCREATIC-CANCER;
   MANAGEMENT; RELIEF; ACUPUNCTURE; ALCOHOL
AB Background: Abdominal pain from primary cancer or metastatic disease is a significant cause of pain for patients undergoing treatment for the disease. Patient's pain may be resistant to conventional analgesics. The need for timely pain relief in order to facilitate further care in the cancer treatment plan should be a priority.
   Objectives: The aim of this retrospective observational review was to assess the relief given with a low volume neurolytic retrocrural celiac plexus nerve block, the duration of the procedure, the duration of relief, the reduction in daily opioid consumption, and the improvement of quality of life in a patient suffering from incapacitating abdominal pain due to primary abdominal malignancy or abdominal metastatic disease. Patients were given a neurolytic celiac plexus block without previous diagnostic block due to multiple comorbidities.
   Study Design: This is a retrospective, observational study.
   Methods: Five hundred and seven patients were studied and data at 5 months for 455 patients were retained at the end of the review. They were evaluated in the pain center prior to and after the neurolytic retrocrural celiac plexus nerve block under fluoroscopic guidance. They were assessed on duration of procedure, pain scores (numeric rating scale 0-10), daily opioid consumption, quality of life improvement (simple yes or no question at 3 months) and routine follow-up during treatment for the cancer for 6 months or end of life. All data was gathered by extensive chart review and placed on a spreadsheet for analysis.
   Results: Follow-up was completed 6 months after the procedure. Pain scores, daily opioid consumption, and quality of life showed improvement for the duration of the study. There was some return in pain during the fourth to sixth month due to disease progression and the anticipated duration of the neurolytic agent. Some short duration known side effects did occur. An initial vascular contrast uptake of 6.7% was noted during the procedure while utilizing digital subtraction angiography with fluoroscopy.
   Limitations: A larger sample size would be ideal, as well as, a prospective trial with a control group, but this is unrealistic in our patient population. A proven quality of life questionnaire would be beneficial. Comparing alcohol, phenol and radiofrequency thermocoagulation would be interesting to equate duration, effect, and side effects.
   Conclusion: Low volume neurolytic retrocrural celiac plexus nerve block with phenol is a safe procedure providing up to 6 months of pain relief and is an effective, well-established, minimally time-consuming procedure for abdominal pain due to primary malignancy or metastatic spread.
C1 [Rahman, Abed; Rahman, Raed; Macrinici, George] Midwestern Reg Med Ctr, Dept Pain Med, Intervent Pain Management, 2520 Elisha Ave, Zion, IL 60099 USA.
   [Li, Sam] JHS Hosp Cook Cty, Dept Anesthesiol & Pain Management, Chicago, IL USA.
C3 John H Stroger Junior Hospital Cook County
RP Rahman, A (corresponding author), Midwestern Reg Med Ctr, Dept Pain Med, Intervent Pain Management, 2520 Elisha Ave, Zion, IL 60099 USA.
EM Abed.rahman@ctca-hope.com
CR [Anonymous], 2015, CANC FACTS FIG 2015
   Best CA, 2015, PLAST SURG-CHIR PLAS, V23, P87, DOI 10.1177/229255031502300206
   Bhaskar AK, 2012, CURR OPIN SUPPORT PA, V6, P1, DOI 10.1097/SPC.0b013e32835017e7
   Bjelic-Radisic V, 2012, EUR J CANCER, V48, P3009, DOI 10.1016/j.ejca.2012.05.011
   Buscher HCJL, 2012, SURG ENDOSC, V26, P2183, DOI 10.1007/s00464-012-2152-4
   Elahi F, 2013, ANESTHESIOLOGY, V118, P187, DOI 10.1097/ALN.0b013e3182600eca
   Gong HB, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003061
   ISCHIA S, 1992, ANESTHESIOLOGY, V76, P534, DOI 10.1097/00000542-199204000-00008
   Kamdar MM, 2015, REGION ANESTH PAIN M, V40, P610, DOI 10.1097/AAP.0000000000000290
   Kilian-Kita A, 2016, WSPOLCZESNA ONKOL, V20, P119, DOI 10.5114/wo.2016.60065
   Koyyalagunta D, 2016, PAIN PHYSICIAN, V19, P281, DOI 10.36076/ppj/2019.19.281
   Lahoud MJ, 2016, WORLD J GASTRO ONCOL, V8, P599, DOI 10.4251/wjgo.v8.i8.599
   Loukas M, 2010, CLIN ANAT, V23, P512, DOI 10.1002/ca.20964
   McAninch Scott A, 2016, Proc (Bayl Univ Med Cent), V29, P329
   Novy D, 2016, PAIN PHYSICIAN, V19, P397, DOI 10.36076/ppj/2016.19.397
   Nurwidya F, 2016, ADV RESPIR MED, V84, P331, DOI 10.5603/ARM.2016.0043
   Oh B, 2017, ACUPUNCT MED, V35, P107, DOI 10.1136/acupmed-2016-011115
   Papadopoulos D, 2013, PAIN PHYSICIAN, V16, P125
   RAJ P, 1996, PAIN MED COMPREHENSI, P227
   Shwita AH, 2015, KOREAN J PAIN, V28, P22, DOI 10.3344/kjp.2015.28.1.22
   Tewari S, 2016, INDIAN J PALLIAT CAR, V22, P301, DOI 10.4103/0973-1075.185041
   VENTAFRIDDA V, 1987, CANCER-AM CANCER SOC, V59, P850, DOI 10.1002/1097-0142(19870215)59:4<850::AID-CNCR2820590432>3.0.CO;2-1
   Vorenkamp K., 2011, Tech Reg Anesth Pain Manag, V15, P28, DOI [10.1053/j.trap.2011.03.001, DOI 10.1053/J.TRAP.2011.03.001]
   WONG GY, 1995, REGION ANESTH, V20, P352, DOI 10.1136/rapm-00115550-199520040-00013
   Yajima R, 2016, J PHARM HEALTH CARE, V2, DOI 10.1186/s40780-016-0063-6
   Yang HJ, 2008, CLIN ANAT, V21, P171, DOI 10.1002/ca.20599
NR 26
TC 11
Z9 13
U1 0
U2 2
PU AM SOC INTERVENTIONAL PAIN PHYSICIANS
PI PADUCAH
PA 81 LAKEVIEW DR, PADUCAH, KY 42001 USA
SN 1533-3159
J9 PAIN PHYSICIAN
JI Pain Physician
PD SEP-OCT
PY 2018
VL 21
IS 5
BP 497
EP 504
PG 8
WC Anesthesiology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA GV1AY
UT WOS:000445800200020
PM 30282394
OA Bronze
DA 2026-01-16
ER

PT J
AU Zou, X
   Yang, YC
   Wang, Y
   Pei, W
   Han, JG
   Lu, Y
   Zhang, MS
   Tu, JF
   Lin, LL
   Wang, LQ
   Shi, GX
   Yan, SY
   Yang, JW
   Liu, CZ
AF Zou, Xuan
   Yang, Ying-Chi
   Wang, Yu
   Pei, Wei
   Han, Jia-Gang
   Lu, Yun
   Zhang, Mao-Shen
   Tu, Jian Feng
   Lin, Lu Lu
   Wang, Li-Qiong
   Shi, Guangxia
   Yan, Shi-Yan
   Yang, Jing-Wen
   Liu, Cun-Zhi
TI Electroacupuncture versus sham electroacupuncture in the treatment of
   postoperative ileus after laparoscopic surgery for colorectal cancer:
   study protocol for a multicentre, randomised, sham-controlled trial
SO BMJ OPEN
LA English
DT Article
DE COMPLEMENTARY MEDICINE; Functional bowel disorders; Gastrointestinal
   tumours; Endoscopic surgery
ID POSTPRANDIAL DISTRESS SYNDROME; GASTROINTESTINAL MOTILITY; ACUPUNCTURE;
   RECOVERY; PATHOPHYSIOLOGY; COMPLICATIONS; DISORDERS
AB Introduction Postoperative ileus (POI) is an inevitable complication of almost all abdominal surgeries, which results in prolonged hospitalisation and increased healthcare costs. Various treatment strategies have been developed for POI but with limited success. Electroacupuncture (EA) might be a potential therapy for POI. However, evidence from rigorous trials that evaluated the effectiveness of EA for POI is limited. Thus, the aim of this study was to examine whether EA can safely reduce the time to the first defecation after laparoscopic surgery in patients with POI. Methods and analysis This multicentre randomised sham-controlled trial will be conducted in four hospitals in China. A total of 248 eligible participants with colorectal cancer who will undergo laparoscopic surgery will be randomly allocated to an EA group and a sham EA group in a 1:1 ratio. Treatment will be performed starting on postoperative day 1 and continued for four consecutive days, once per day. If the participant is discharged within 4 days after surgery, the treatment will cease on the day of discharge. The primary outcome will be the time to first defecation. The secondary outcome measures will include time to first flatus, tolerability of semiliquid and solid food, length of postoperative hospital stay, postoperative nausea and vomiting, abdominal distension, postoperative pain, postoperative analgesic, time to first ambulation, blinding assessment, credibility and expectancy and readmission rate. Ethics and dissemination Ethics approval was obtained from the Ethics Committee of Beijing University of Chinese Medicine (number 2020BZHYLL0116) and the institutional review board of each hospital. The results will be disseminated through peer-reviewed publications. This study protocol (V.3.0, 6 March 2020) involves human participants and was approved by the ethics committees of Beijing University of Chinese Medicine (number 2020BZHYLL0116), Beijing Friendship Hospital Affiliated to Capital Medical University (number 2020-P2-069-01), Beijing Chao-Yang Hospital Affiliated to Capital Medical University (number 2020-3-11-2), National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (number 20/163-2359), and the Affiliated Hospital of Qingdao University (number QYFYKYLL711311920). The participants gave informed consent to participate in the study before taking part.
C1 [Zou, Xuan; Wang, Yu; Tu, Jian Feng; Lin, Lu Lu; Wang, Li-Qiong; Shi, Guangxia; Yan, Shi-Yan; Yang, Jing-Wen; Liu, Cun-Zhi] Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Beijing, Peoples R China.
   [Zou, Xuan; Wang, Yu; Tu, Jian Feng; Lin, Lu Lu; Wang, Li-Qiong; Shi, Guangxia; Yan, Shi-Yan; Yang, Jing-Wen; Liu, Cun-Zhi] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
   [Yang, Ying-Chi] Capital Med Univ, Beijing Friendship Hosp, Beijing, Peoples R China.
   [Pei, Wei] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, Canc Hosp, Beijing, Peoples R China.
   [Han, Jia-Gang] Capital Med Univ, Beijing Chao Yang Hosp, Beijing, Peoples R China.
   [Lu, Yun; Zhang, Mao-Shen] Qingdao Univ, Affiliated Hosp, Qingdao, Shandong, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Capital Medical University; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Cancer Institute & Hospital -
   CAMS; Peking Union Medical College; Capital Medical University; Qingdao
   University
RP Yan, SY; Yang, JW (corresponding author), Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Beijing, Peoples R China.; Yan, SY; Yang, JW (corresponding author), Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
EM ysy20200927@163.com; yangjw0626@126.com
RI Lin, Lulu/JSL-6136-2023; Liu, Cunzhi/J-9190-2017; Yan,
   Shiyan/J-7224-2013; Tu, Jian-Feng/J-7768-2017; WANG, Yu/OSI-5971-2025;
   PEI, WEI/HNC-0257-2023
OI PEI, WEI/0000-0001-5201-6432
FU National Key R&D Program of China [2019YFC1712100]
FX This study was supported by the National Key R&D Program of China
   (number 2019YFC1712100). The sponsors have no roles in the design of the
   study; collection, analysis and interpretation of data; and writing of
   the manuscript.
CR AUN C, 1986, PAIN, V25, P215, DOI 10.1016/0304-3959(86)90095-3
   Bian ZX, 2011, ANN INTERN MED, V154, P290, DOI 10.7326/0003-4819-154-4-201102150-00016
   Brown SR, 2014, ANN SURG, V259, P916, DOI 10.1097/SLA.0000000000000407
   Chapman SJ, 2018, BRIT J SURG, V105, P797, DOI 10.1002/bjs.10781
   Chen JDZ, 2018, NEUROGASTROENT MOTIL, V30, DOI 10.1111/nmo.13393
   Chen KB, 2019, INT J SURG, V70, P93, DOI 10.1016/j.ijsu.2019.08.034
   Chen L., 2018, Chinese Journal of Practical Surgery, V38, P1
   Devilly GJ, 2000, J BEHAV THER EXP PSY, V31, P73, DOI 10.1016/S0005-7916(00)00012-4
   Dindo D, 2004, ANN SURG, V240, P205, DOI [10.17116/hirurgia2018090162, 10.1097/01.sla.0000133083.54934.ae]
   Doorly MG, 2012, SURG CLIN N AM, V92, P259, DOI 10.1016/j.suc.2012.01.010
   Fang JF, 2017, SCI REP-UK, V7, DOI 10.1038/srep39801
   Gkegkes ID, 2020, DIGEST SURG, V37, P22, DOI 10.1159/000496431
   Harnsberger CR, 2019, CLIN COLON RECT SURG, V32, P166, DOI 10.1055/s-0038-1677003
   Horowitz JA, 2018, WORLD NEUROSURG, V115, pE185, DOI 10.1016/j.wneu.2018.04.006
   Hou YQ, 2019, TRIALS, V20, DOI 10.1186/s13063-018-3051-3
   Kim KH, 2016, ACUPUNCT MED, V34, P248, DOI 10.1136/acupmed-2015-010941
   Landrum Laurie, 2006, Qual Manag Health Care, V15, P83
   Li LDT, 2013, J AM GERIATR SOC, V61, P1175, DOI 10.1111/jgs.12307
   Li Y, 2012, CAN MED ASSOC J, V184, P401, DOI 10.1503/cmaj.110551
   Liu YH, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/3178472
   Liu ZS, 2017, JAMA-J AM MED ASSOC, V317, P2493, DOI 10.1001/jama.2017.7220
   Ma TT, 2012, ALIMENT PHARM THER, V35, P552, DOI 10.1111/j.1365-2036.2011.04979.x
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Moffet HH, 2009, J ALTERN COMPLEM MED, V15, P213, DOI 10.1089/acm.2008.0356
   Ng SSM, 2013, GASTROENTEROLOGY, V144, P307, DOI 10.1053/j.gastro.2012.10.050
   Person B, 2006, CURR PROB SURG, V43, P6, DOI 10.1067/j.cpsurg.2005.10.003
   Peters EG, 2020, NEUROGASTROENT MOTIL, V32, DOI 10.1111/nmo.13862
   Ravikumar R, 2017, BMJ-BRIT MED J, V357, DOI 10.1136/bmj.j1455
   Rollins KE, 2019, ANN SURG, V270, P43, DOI 10.1097/SLA.0000000000003145
   Sen S, 2020, J ORAL REHABIL, V47, P783, DOI 10.1111/joor.12952
   Stakenborg N, 2017, HANDB EXP PHARMACOL, V239, P39, DOI 10.1007/164_2016_108
   Sultan S, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012111.pub2
   Sun DL, 2020, ANN TRANSL MED, V8, DOI 10.21037/atm.2020.01.95
   Tevis SE, 2015, J GASTROINTEST SURG, V19, P1684, DOI 10.1007/s11605-015-2877-1
   van Bree SHW, 2014, ANN SURG, V259, P708, DOI 10.1097/SLA.0b013e318293ee55
   van Bree SHW, 2012, NAT REV GASTRO HEPAT, V9, P675, DOI 10.1038/nrgastro.2012.134
   Venara A, 2016, J VISC SURG, V153, P439, DOI 10.1016/j.jviscsurg.2016.08.010
   Wang HG, 2018, MED SCI MONITOR, V24, P7231, DOI 10.12659/MSM.910817
   Wong ELY, 2011, BMC HEALTH SERV RES, V11, DOI 10.1186/1472-6963-11-149
   Wu ZQ, 2015, EUR SURG RES, V54, P127, DOI 10.1159/000369529
   Xu SB, 2013, CAN MED ASSOC J, V185, P473, DOI 10.1503/cmaj.121108
   Yang JW, 2020, ANN INTERN MED, V172, P777, DOI 10.7326/M19-2880
   Yang NN, 2020, NEUROGASTROENT MOTIL, V32, DOI 10.1111/nmo.13808
   Yang Y, 2017, SCI REP-UK, V7, DOI 10.1038/srep37826
   Yin JY, 2010, AUTON NEUROSCI-BASIC, V157, P31, DOI 10.1016/j.autneu.2010.03.007
   You XM, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001968
   Zhang X, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/860631
   Zhao L, 2019, JAMA INTERN MED, V179, P1388, DOI 10.1001/jamainternmed.2019.2407
   Zhou JZ, 2017, NEUROMODULATION, V20, P767, DOI 10.1111/ner.12602
NR 49
TC 4
Z9 6
U1 2
U2 21
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD APR
PY 2022
VL 12
IS 4
AR e050000
DI 10.1136/bmjopen-2021-050000
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0O9KM
UT WOS:000783842400023
PM 35428615
OA Green Submitted, Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Qi, L
   Shi, HS
   Zhang, YS
   Zhang, XC
   Jia, HL
   Tian, H
AF Qi, Lin
   Shi, Hongshuo
   Zhang, Yunsong
   Zhang, Xuecheng
   Jia, Hongling
   Tian, Hu
TI The effect of acupuncture on recovery after colorectal cancer resection:
   A systematic review meta-analysis of randomized controlled trials
SO MEDICINE
LA English
DT Review
DE abdominal surgery; acupuncture; colorectal cancer; meta-analysis
ID POSTOPERATIVE NAUSEA; ELECTROACUPUNCTURE; SURGERY; CHEMOTHERAPY;
   PREVENTION; MECHANISMS; MOTILITY
AB Background:To evaluate the efficacy and safety of acupuncture by systematically reviewing the literature on colorectal cancer resection.Methods:Seven electronic databases were searched from inception to February 28, 2023. Randomized controlled trials on acupuncture in patients after CRC resection were included. Two reviewers independently selected relevant trials, extracted data, and assessed the risk of bias. A random-effects meta-analysis model was used to obtain summary effect estimates. The data were pooled and analyzed using RevMan 5.3. The heterogeneity of selected studies was evaluated by evaluating the I-squared (I2) statistics.Results:Twenty-two studies with 1878 patients were included. Results of the meta-analysis showed there was a low level evidence that acupuncture may improve early postoperative symptoms, such as time to first flatus (n = 876, MD -0.77h, 95% CI -1.22 to -0.33 h, I2 = 89%), time to first bowel movement (n = 671, MD -1.41h, 95% CI -2.20 to -0.63 h, I2 = 95%), time to first defecation (n = 556, MD -1.03h, 95% CI -1.88 to -0.18 h, I2 = 95%), and nausea/vomiting (n = 1488, RR 0.72, 95% CI 0.59-0.89, I2 = 49%) compared with usual care and sham acupuncture. However, there were no statistically significant differences in postoperative pain (n = 1188, MD-0.21, 95% CI -0.59 to 0.17, I2 = 74%). And there was no sufficient evidence of improving long-term functional outcomes. There was substantial heterogeneity across trials. The adverse events associated with acupuncture stimulation were minor in include studies.Conclusion subsections:There is currently low-level evidence supporting the use of acupuncture on postoperative symptoms for patients after colorectal cancer resection. More investigations should be established based on the STRICTA statement strictly.
C1 [Qi, Lin; Shi, Hongshuo; Tian, Hu] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan, Peoples R China.
   [Zhang, Yunsong] Shandong Univ Tradit Chinese Med, Affiliated Hosp 1, Jinan, Peoples R China.
   [Zhang, Xuecheng] Beijing Univ Chinese Med, Beijing, Peoples R China.
   [Jia, Hongling] Shandong Univ Tradit Chinese Med, Affiliated Hosp 2, Jinan, Peoples R China.
   [Qi, Lin] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan 250010, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Beijing University of Chinese Medicine;
   Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine
RP Qi, L (corresponding author), Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan 250010, Shandong, Peoples R China.
EM tcmqilin@163.com; 2015111@sdutcm.edu.cn; zhangxuecheng@bucm.edu.cn;
   zhangxuecheng@bucm.edu.cn; jiahl1969@163.com; sdzyydxth@163.com
CR [Anonymous], 2009, BMJ-BRIT MED J, V6, pe1000097, DOI [DOI 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, DOI 10.1371/JOURNAL.PMED.1000097]
   Balshem H, 2011, J CLIN EPIDEMIOL, V64, P401, DOI 10.1016/j.jclinepi.2010.07.015
   Bray F, 2020, CA-CANCER J CLIN, V70, P313, DOI 10.3322/caac.21609
   Cao XZ, 2017, J ANESTH, V31, P617, DOI 10.1007/s00540-017-2363-x
   Chan KY, 2020, TRIALS, V21, DOI 10.1186/s13063-019-3972-5
   Chen JB, 2020, INT J SURG, V73, P57, DOI 10.1016/j.ijsu.2019.10.036
   Chen KB, 2019, INT J SURG, V70, P93, DOI 10.1016/j.ijsu.2019.08.034
   Chen T-L., Efficacy of acupuncture in prevention of chemotherapy induced peripheral neuropathy - a pilot study
   ChiCtr, 2020, Study on the effect of acupuncture on the gastrointestinal function of patients with colorectal cancer after operation: a randomized controlled trial
   ChiCtr, 2019, Electroacupuncture for postoperative ileus after colorectal cancer surgery: a randomized controlled clinical study
   Deng G, 2013, ANN SURG ONCOL, V20, P1164, DOI 10.1245/s10434-012-2759-7
   Du XT, 2021, WORLD J ACUPUNCT-MOX, V31, P83, DOI 10.1016/j.wjam.2020.11.013
   Frey UH, 2009, BRIT J ANAESTH, V102, P620, DOI 10.1093/bja/aep014
   Haddaway NR, 2022, CAMPBELL SYST REV, V18, DOI 10.1002/cl2.1230
   Kim KH, 2016, ACUPUNCT MED, V34, P248, DOI 10.1136/acupmed-2015-010941
   Lan Z., 2019, Gen Nurs, V17, P206
   Lee Y, 2020, SURG ONCOL, V32, P75, DOI 10.1016/j.suronc.2019.11.004
   Li FF, 2018, WORLD J ACUPUNCT-MOX, V28, P151, DOI 10.1016/j.wjam.2018.08.001
   Li Huai-Yu, 2022, Zhongguo Zhen Jiu, V42, P595, DOI 10.13703/j.0255-2930.20210214-0003
   Li L., 2006, China Acupunct Moxibustion, V26, P65
   Lin JG, 2008, AM J CHINESE MED, V36, P635, DOI 10.1142/S0192415X08006107
   Ling X., 2016, Shandong J Tradit Chin Med, V35, P701
   Liska D, 2021, ANN SURG, V273, P772, DOI 10.1097/SLA.0000000000003438
   Liu M., 2017, Journal of Shanghai University of Traditional Chinese Medicine, V31, P38
   Liu XY., 2021, Chin J Colorectal Dis, V10, P605, DOI [10.3877/cma.j.issn.2095-3224.2021.06.007, DOI 10.3877/CMA.J.ISSN.2095-3224.2021.06.007]
   Liu YH, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/3178472
   Luo DH, 2018, STAT METHODS MED RES, V27, P1785, DOI 10.1177/0962280216669183
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Mai Sicong, 2017, Zhongguo Zhen Jiu, V37, P483, DOI 10.13703/j.0255-2930.2017.05.008
   Ng S S M, 2013, Hong Kong Med J, V19 Suppl 9, P33
   Ni XF, 2019, INT J SURG, V69, P108, DOI 10.1016/j.ijsu.2019.07.034
   Ni XF, 2019, J GASTROINTEST SURG, V23, P1502, DOI 10.1007/s11605-019-04170-8
   Oh JE, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.813748
   Patel SG, 2022, LANCET GASTROENTEROL, V7, P262, DOI 10.1016/S2468-1253(21)00426-X
   Stein DJ, 1997, ANESTH ANALG, V84, P342, DOI 10.1097/00000539-199702000-00018
   Sun Hui, 2021, Zhen Ci Yan Jiu, V46, P592, DOI [10.13702/j.1000-0607.200647, 10.13702/j.1000-0607.200647]
   The World Health Organization, 1992, Cancer, V03, P254
   Wang D, 2022, PAIN RES MANAG, V2022, DOI 10.1155/2022/7570533
   Wang XL, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/7837711
   Wanyun T., 2014, Introduction Tradit Chin Med, V20, P39
   Xiangdong P., 2016, China Acupunct Moxibustion, V36, P613
   Xuying G., 2020, Acupunct Res, V45, P315
   Yang JW, 2022, ECLINICALMEDICINE, V49, DOI 10.1016/j.eclinm.2022.101472
   Yang NN, 2020, NEUROGASTROENT MOTIL, V32, DOI 10.1111/nmo.13808
   [姚新宇 Yao Xinyu], 2012, [中华麻醉学杂志, Chinese Journal of Anesthesiology], V32, P820
   Ye Z, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0271580
   Yi W., 2019, Clin J Acupunct Moxibustion Moxibustion, V35, P26
   Ying L., 2021, J Guangzhou Univ Chin Med, V38, P518
   Yu B, 2021, AM J CHINESE MED, V49, P1151, DOI 10.1142/S0192415X21500555
   Yuan W, 2019, CHINESE MED J-PEKING, V132, P707, DOI 10.1097/CM9.0000000000000123
   Yun S., 2019, Integrated Tradit Chin West Med Nurs, V5, P41
   Zhang RX, 2014, ANESTHESIOLOGY, V120, P482, DOI 10.1097/ALN.0000000000000101
   Zhang S., 2020, Zhejiang J Tradit Chin Med, V55, P215
   Zhang Shuang-yan, 2011, Zhongguo Zhen Jiu, V31, P513
   Zhang WL, 2022, AM J CHINESE MED, V50, P961, DOI 10.1142/S0192415X22500392
   Zhang ZD, 2014, ACUPUNCT MED, V32, P223, DOI 10.1136/acupmed-2013-010490
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
NR 57
TC 5
Z9 6
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP 1
PY 2023
VL 102
IS 35
AR e34678
DI 10.1097/MD.0000000000034678
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q8JQ7
UT WOS:001059934400012
PM 37657054
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Romero, SAD
   Emard, N
   Baser, RE
   Panageas, K
   MacLeod, J
   Walker, D
   Barton-Burke, M
   Liou, K
   Deng, G
   Farrar, J
   Xiao, H
   Mao, JJ
   Epstein, A
AF Romero, Sally A. D.
   Emard, Nicholas
   Baser, Raymond E.
   Panageas, Katherine
   MacLeod, Jodi
   Walker, Desiree
   Barton-Burke, Margaret
   Liou, Kevin
   Deng, Gary
   Farrar, John
   Xiao, Han
   Mao, Jun J.
   Epstein, Andrew
TI Acupuncture versus massage for pain in patients living with advanced
   cancer: a protocol for the IMPACT randomised clinical trial
SO BMJ OPEN
LA English
DT Article
ID INSOMNIA SEVERITY INDEX; INHIBITOR-RELATED ARTHRALGIA; FALSE DISCOVERY
   RATE; BREAST-CANCER; HOSPITAL ANXIETY; ONCOLOGY MASSAGE; DEPRESSION
   SCALE; UNITED-STATES; OUTCOMES; THERAPY
AB Introduction Pain, comorbid fatigue and sleep disturbances are common and distressing symptoms for patients with advanced cancer, negatively impacting their quality of life. Clinical guidelines recommend non-pharmacological interventions, including acupuncture and massage, for pain management in adult patients with cancer in adjunct to conventional care. However, high-quality evidence about the comparative effectiveness and long-term durability of these therapies for symptom management is limited.
   Methods and analysis We describe the design of a two-arm, parallel group, multicentre randomised controlled trial that investigates the use of acupuncture versus massage for musculoskeletal pain among 300 patients with diverse types of advanced cancer. The primary aim is to evaluate the long-term effectiveness (26 weeks from randomisation) of acupuncture vs massage for pain (primary outcome) and comorbid symptoms (fatigue, sleep disturbance and quality of life). The secondary aim is to identify patient-level demographic characteristics (eg, sex, race, age), clinical factors (eg, insomnia, pain severity) and psychological attributes that are associated with a greater reduction in pain for either acupuncture or massage. Patients will receive weekly acupuncture or massage treatments for 10 weeks, followed by monthly booster sessions up to 26 weeks. The primary endpoint will be the change in worst pain intensity score from baseline to 26 weeks. We will collect validated patient-reported outcomes at multiple time points over 26 weeks.
   Ethics and dissemination The Institutional Review Board at Memorial Sloan Kettering Cancer Center in New York approved this protocol. Results will be disseminated via peer-reviewed scientific journals and conference presentations. Our findings will help patients and healthcare providers make informed decisions about incorporating non-pharmacological treatments to manage pain for patients with advanced cancer.
C1 [Romero, Sally A. D.] Univ Calif San Diego, Dept Obstet Gynecol & Reprod Sci, San Diego, CA 92103 USA.
   [Emard, Nicholas; Panageas, Katherine] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, 1275 York Ave, New York, NY 10021 USA.
   [Baser, Raymond E.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.
   [MacLeod, Jodi; Walker, Desiree; Liou, Kevin; Deng, Gary; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1275 York Ave, New York, NY 10021 USA.
   [Barton-Burke, Margaret] Mem Sloan Kettering Canc Ctr, Off Nursing Res, 1275 York Ave, New York, NY 10021 USA.
   [Farrar, John] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.
   [Xiao, Han; Epstein, Andrew] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
C3 University of California System; University of California San Diego;
   Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering
   Cancer Center; University of Pennsylvania; Memorial Sloan Kettering
   Cancer Center
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1275 York Ave, New York, NY 10021 USA.
EM maoj@mskcc.org
OI Emard, Nicholas/0000-0003-4786-4423
FU Patient-Centered Outcomes Research Institute (PCORI)
   [SMPAI-2018C2-12883]; National Institutes of Health/National Cancer
   Institute Cancer Center [P30 CA008748]; Translational and Integrative
   Medicine Research Fund at Memorial Sloan Kettering Cancer Center;
   National Cancer Institute [P30CA008748] Funding Source: NIH RePORTER
FX Research reported in this article was funded through a Patient-Centered
   Outcomes Research Institute (PCORI) award (SMPAI-2018C2-12883). The
   statements presented in this work are solely the responsibility of the
   authors and do not necessarily represent the views of the
   Patient-Centered Outcomes Research Institute (PCORI), its Board of
   Governors or Methodology Committee. It was also supported in part
   through the National Institutes of Health/National Cancer Institute
   Cancer Center Support Grant (P30 CA008748) and the Translational and
   Integrative Medicine Research Fund (award/grant number not applicable)
   at Memorial Sloan Kettering Cancer Center.
CR [Anonymous], 2014, Medicine Hands: Massage Therapy for People With Cancer
   [Anonymous], 2017, Cancer facts and statistics
   Barile JP, 2013, QUAL LIFE RES, V22, P1201, DOI 10.1007/s11136-012-0246-z
   Bastien CH, 2001, SLEEP MED, V2, P297, DOI 10.1016/S1389-9457(00)00065-4
   Benjamini Y, 2001, ANN STAT, V29, P1165
   BENJAMINI Y, 1995, J ROY STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Boyd C, 2016, PAIN MED, V17, P1553, DOI 10.1093/pm/pnw100
   Buckenmaier C, 2016, PAIN MED, V17, P1211, DOI 10.1093/pm/pnw092
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   Chen LX, 2013, JCR-J CLIN RHEUMATOL, V19, P308, DOI 10.1097/RHU.0b013e3182a21848
   Chen P.Y., 2008, INT J BIOSTAT, P4, DOI DOI 10.2202/1557-4679.1098
   Cheng Xin-Nong., 1987, Chinese acupuncture and moxibustion
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Cleeland CS, 2013, CANCER-AM CANCER SOC, V119, P4333, DOI 10.1002/cncr.28376
   Colagiuri B, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/857804
   Commission TJ, 2018, R3 REP ISS 11 PAIN A
   Delgado-Guay MO, 2018, J PALLIAT MED, V21, P678, DOI 10.1089/jpm.2017.0236
   Dodd M J, 2001, Oncol Nurs Forum, V28, P465
   Dodd MJ, 2010, EUR J ONCOL NURS, V14, P101, DOI 10.1016/j.ejon.2009.09.005
   Dong ST, 2016, SUPPORT CARE CANCER, V24, P1373, DOI 10.1007/s00520-015-2913-4
   Dong ST, 2014, J PAIN SYMPTOM MANAG, V48, P411, DOI 10.1016/j.jpainsymman.2013.10.027
   Dowell D, 2016, JAMA-J AM MED ASSOC, V315, P1624, DOI 10.1001/jama.2016.1464
   Farrar JT, 2010, J PAIN, V11, P109, DOI 10.1016/j.jpain.2009.06.007
   Farrar JT, 2001, PAIN, V94, P149, DOI 10.1016/S0304-3959(01)00349-9
   Farrar JT, 2000, PAIN, V88, P287, DOI 10.1016/S0304-3959(00)00339-0
   Garland SN, 2016, CONTEMP CLIN TRIALS, V47, P349, DOI 10.1016/j.cct.2016.02.010
   Hays RD, 2009, QUAL LIFE RES, V18, P873, DOI 10.1007/s11136-009-9496-9
   Henderson NC, 2016, HEALTH SERV OUTCOME, V16, P213, DOI 10.1007/s10742-016-0159-3
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hurst H, 2004, J MANIP PHYSIOL THER, V27, P26, DOI 10.1016/j.jmpt.2003.11.003
   Imai K, 2013, ANN APPL STAT, V7, P443, DOI 10.1214/12-AOAS593
   Johnsen AT, 2009, PALLIATIVE MED, V23, P491, DOI 10.1177/0269216309105400
   Kalauokalani D, 2001, SPINE, V26, P1418, DOI 10.1097/00007632-200107010-00005
   Keefe JR, 2017, J PSYCHIATR RES, V84, P90, DOI 10.1016/j.jpsychires.2016.09.029
   Kent DM, 2010, TRIALS, V11, DOI 10.1186/1745-6215-11-85
   Kirkova J, 2011, AM J HOSP PALLIAT ME, V28, P350, DOI 10.1177/1049909110391464
   Kutner JS, 2008, ANN INTERN MED, V149, P369, DOI 10.7326/0003-4819-149-6-200809160-00003
   Lin CC, 2006, J PAIN SYMPTOM MANAG, V32, P52, DOI 10.1016/j.jpainsymman.2005.12.019
   Liou KT, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000020085
   Lopez G, 2017, SUPPORT CARE CANCER, V25, P3645, DOI 10.1007/s00520-017-3784-7
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Mao JJ, 2009, INTEGR CANCER THER, V8, P123, DOI 10.1177/1534735409332903
   Mao Jun J, 2007, Acupunct Med, V25, P158
   Mao JJ, 2007, EXPLORE-NY, V3, P372, DOI 10.1016/j.explore.2006.12.003
   Mao JJ, 2021, JAMA ONCOL, V7, P720, DOI 10.1001/jamaoncol.2021.0310
   Mao JJ, 2017, J ONCOL PRACT, V13, pE207, DOI 10.1200/JOP.2016.015081
   Mao JJ, 2015, J CLIN ONCOL, V33, P3615, DOI 10.1200/JCO.2015.60.9412
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Mao JJ, 2010, PRIMARY CARE, V37, P105, DOI 10.1016/j.pop.2009.09.010
   Mendoza TR, 1999, CANCER-AM CANCER SOC, V85, P1186, DOI 10.1002/(SICI)1097-0142(19990301)85:5<1186::AID-CNCR24>3.0.CO;2-N
   Miaskowski Christine, 2006, Oncol Nurs Forum, V33, pE79, DOI 10.1188/06.ONF.E79-E89
   MOOREY S, 1991, BRIT J PSYCHIAT, V158, P255, DOI 10.1192/bjp.158.2.255
   Morin CM, 2011, SLEEP, V34, P601, DOI 10.1093/sleep/34.5.601
   Network NCC, 2018, NCCN CLIN PRACTICE G
   Paice JA, 2016, J CLIN ONCOL, V34, P3325, DOI 10.1200/JCO.2016.68.5206
   Porta-Sales J, 2015, J PALLIAT MED, V18, P923, DOI 10.1089/jpm.2015.29002.jps
   Qaseem A, 2017, ANN INTERN MED, V166, P514, DOI 10.7326/M16-2367
   Revicki DA, 2009, QUAL LIFE RES, V18, P783, DOI 10.1007/s11136-009-9489-8
   Robinson-Papp J, 2015, J PAIN SYMPTOM MANAG, V50, P381, DOI 10.1016/j.jpainsymman.2015.03.013
   Rothrock NE, 2010, J CLIN EPIDEMIOL, V63, P1195, DOI 10.1016/j.jclinepi.2010.04.012
   Savard MH, 2005, PSYCHO-ONCOLOGY, V14, P429, DOI 10.1002/pon.860
   Schulz KF, 2010, BMJ-BRIT MED J, V340, DOI [10.1136/bmj.c869, 10.1136/bmj.c332]
   Smith AB, 2002, PSYCHOL PSYCHOTHER-T, V75, P165, DOI 10.1348/147608302169625
   Swarm RA, 2013, J NATL COMPR CANC NE, V11, P992, DOI 10.6004/jnccn.2013.0119
   Tango T, 2017, J BIOPHARM STAT, V27, P963, DOI 10.1080/10543406.2017.1293083
   Tick H, 2018, EXPLORE-NY, V14, P177, DOI 10.1016/j.explore.2018.02.001
   van den Beuken-van Everdingen MHJ, 2016, J PAIN SYMPTOM MANAG, V51, P1070, DOI 10.1016/j.jpainsymman.2015.12.340
   Wager S, 2018, J AM STAT ASSOC, V113, P1228, DOI 10.1080/01621459.2017.1319839
   Walsh D, 2000, SUPPORT CARE CANCER, V8, P175, DOI 10.1007/s005200050281
   Walsh D, 2006, SUPPORT CARE CANCER, V14, P831, DOI 10.1007/s00520-005-0899-z
   Walton T, 2010, Medical Conditions and Massage Therapy: A Decision Tree Approach
   Wang CG, 2018, J STAT SOFTW, V85, P1, DOI 10.18637/jss.v085.i07
   Yun Hyeongjun, 2017, Journal of the National Cancer Institute Monographs, P29, DOI [10.1093/jncimonographs/lgx004, 10.1093/jncimonographs/lgx004]
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 76
TC 5
Z9 5
U1 5
U2 30
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD SEP
PY 2022
VL 12
IS 9
AR e058281
DI 10.1136/bmjopen-2021-058281
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4M6LJ
UT WOS:000853434200053
PM 36581960
OA Green Submitted, Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Yang, MX
   Liou, KT
   Garland, SN
   Bao, T
   Hung, TKW
   Li, SSQ
   Li, YL
   Mao, JJ
AF Yang, Mingxiao
   Liou, Kevin T.
   Garland, Sheila N.
   Bao, Ting
   Hung, Tony K. W.
   Li, Susan Q.
   Li, Yuelin
   Mao, Jun J.
TI Acupuncture versus cognitive behavioral therapy for pain among cancer
   survivors with insomnia: an exploratory analysis of a randomized
   clinical trial
SO NPJ BREAST CANCER
LA English
DT Article
ID SEVERITY INDEX; SLEEP DISTURBANCE; ADULTS; VALIDATION; MANAGEMENT;
   MEDICATION; SYMPTOMS
AB Pain and insomnia often co-occur and impair the quality of life in cancer survivors. This study evaluated the effect of acupuncture versus cognitive behavioral therapy for insomnia (CBT-I) on pain severity among cancer survivors with comorbid pain and insomnia. Using data from the CHOICE trial that compared acupuncture versus CBT-I for insomnia among cancer survivors, we analyzed the effect of interventions on pain outcomes in 70 patients with moderate to severe baseline pain. Interventions were delivered over eight weeks. We assessed average pain severity (primary outcome) and pain interference at baseline, week 8, and week 20. We further defined insomnia and pain responders as patients who achieved clinically meaningful improvement in insomnia and pain outcomes, respectively, at week 8. We found that compared with baseline, the between-group difference (-1.0, 95% CI -1.8 to -0.2) was statistically significant favoring acupuncture for reduced pain severity at week 8 (-1.4, 95% CI -2.0 to -0.8) relative to CBT-I (-0.4, 95% CI-1.0 to 0.2). Responder analysis showed that 1) with acupuncture, insomnia responders reported significantly greater pain reduction from baseline to week 4, compared with insomnia non-responders (-1.5, 95% CI -2.7 to -0.3); 2) with CBT-I, pain responders reported significantly greater insomnia reduction at week 8, compared with pain non-responders (-4.7, 95% CI -8.7 to -1.0). These findings suggest that among cancer survivors with comorbid pain and insomnia, acupuncture led to rapid pain reductions, which contributed to a decrease in insomnia, whereas CBT-I had a delayed effect on pain, possibly achieved by insomnia improvement.
C1 [Yang, Mingxiao; Liou, Kevin T.; Bao, Ting; Li, Susan Q.; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
   [Garland, Sheila N.] Mem Univ, Dept Psychol & Discipline Oncol, 232 Elizabeth Ave, St John, NF A1B 3X9, Canada.
   [Hung, Tony K. W.] Mem Sloan Kettering Canc Ctr, Dept Med, Div Solid Tumor Oncol Head & Neck Oncol Serv, 1275 York Ave, New York, NY 10065 USA.
   [Li, Yuelin] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, 1275 York Ave, New York, NY 10065 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial University
   Newfoundland; Memorial Sloan Kettering Cancer Center; Memorial Sloan
   Kettering Cancer Center
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
EM maoj@mskcc.org
RI Garland, Sheila/AGL-7759-2022; Hung, Tony Kin Wai/LLK-9898-2024; Yang,
   Mingxiao/ABF-6416-2021
OI Mao, Jun/0000-0001-9229-0380; Hung, Tony Kin Wai/0000-0002-3872-5512;
   Yang, Mingxiao/0000-0002-6514-3366; Liou, Kevin/0000-0002-2438-9749
FU Patient-Centered Outcomes Research Institute (PCORI) award
   [CER-1403-14292]; National Institutes of Health/National Cancer
   Institute Cancer Center [P30 CA008748]; Translational and Integrative
   Medicine Research Fund at Memorial Sloan Kettering Cancer Center;
   National Cancer Institute [P30CA008748] Funding Source: NIH RePORTER
FX This work is supported in part by a Patient-Centered Outcomes Research
   Institute (PCORI) award (CER-1403-14292), by a grant from the National
   Institutes of Health/National Cancer Institute Cancer Center (P30
   CA008748), and by the Translational and Integrative Medicine Research
   Fund at Memorial Sloan Kettering Cancer Center. The statements presented
   in this article are solely the responsibility of the authors and do not
   necessarily represent the views of the Patient-Centered Outcomes
   Research Institute (PCORI), its Board of Governors, or its Methodology
   Committee. We sincerely thank the CHOICE Study Patient Advisory Board
   members, the study participants, the study therapists, and the research
   staff for their support of this study.
CR [Anonymous], 1980, Diagnostic and Statistical Manual of Mental Disorders, V3rd, DOI DOI 10.1176/APPI.BOOKS.9780890425596
   Babiloni AH, 2020, J NEURAL TRANSM, V127, P647, DOI 10.1007/s00702-019-02067-z
   Bastien CH, 2001, SLEEP MED, V2, P297, DOI 10.1016/S1389-9457(00)00065-4
   Campbell CM, 2015, ARTHRIT CARE RES, V67, P1387, DOI 10.1002/acr.22609
   Cheatle MD, 2016, SLEEP MED CLIN, V11, P531, DOI 10.1016/j.jsmc.2016.08.004
   Chim K, 2013, BMC CANCER, V13, DOI 10.1186/1471-2407-13-401
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Currie SR, 2000, J CONSULT CLIN PSYCH, V68, P407, DOI 10.1037//0022-006X.68.3.407
   Desai K, 2013, SUPPORT CARE CANCER, V21, P43, DOI 10.1007/s00520-012-1490-z
   Edinger JD., 2015, ARCH INTERN MED, V165, P2535
   Farrar JT., 2020, PAIN, V88, P294
   Finan PH, 2014, SLEEP MED CLIN, V9, P261, DOI 10.1016/j.jsmc.2014.02.007
   Fu C, 2017, SLEEP, V40, DOI 10.1093/sleep/zsx153
   Garland SN, 2019, JNCI-J NATL CANCER I, V111, P1323, DOI 10.1093/jnci/djz050
   Garland SN, 2016, CONTEMP CLIN TRIALS, V47, P349, DOI 10.1016/j.cct.2016.02.010
   Haack M, 2020, NEUROPSYCHOPHARMACOL, V45, P205, DOI 10.1038/s41386-019-0439-z
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hershman DL, 2011, BREAST CANCER RES TR, V126, P529, DOI 10.1007/s10549-010-1132-4
   Howell D, 2014, ANN ONCOL, V25, P791, DOI 10.1093/annonc/mdt506
   Inotai A, 2021, CANCER TREAT REV, V100, DOI 10.1016/j.ctrv.2021.102264
   Jungquist CR, 2010, SLEEP MED, V11, P302, DOI 10.1016/j.sleep.2009.05.018
   Koffel E, 2019, PAIN, V160, P529, DOI 10.1097/j.pain.0000000000001423
   Kwak A, 2020, BREAST CANCER RES TR, V181, P269, DOI 10.1007/s10549-020-05635-0
   LAIRD NM, 1982, BIOMETRICS, V38, P963, DOI 10.2307/2529876
   Liu FS, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/5381028
   Loh KP, 2018, J GERIATR ONCOL, V9, P464, DOI 10.1016/j.jgo.2018.02.006
   Ma Y, 2021, SLEEP MED REV, V55, DOI 10.1016/j.smrv.2020.101376
   Mandelblatt JS, 2020, CANCER-AM CANCER SOC, V126, P1183, DOI 10.1002/cncr.32663
   Mazor M, 2019, CANCER-AM CANCER SOC, V125, P4509, DOI 10.1002/cncr.32477
   McCrae CS, 2019, SLEEP, V42, DOI 10.1093/sleep/zsy234
   McCurry SM, 2021, JAMA INTERN MED, V181, P530, DOI 10.1001/jamainternmed.2020.9049
   Morin CM, 2014, SLEEP MED, V15, P701, DOI 10.1016/j.sleep.2014.02.004
   Morin CM, 2011, SLEEP, V34, P601, DOI 10.1093/sleep/34.5.601
   Morin CM, 2009, JAMA-J AM MED ASSOC, V301, P2005, DOI 10.1001/jama.2009.682
   Pachman DR, 2012, J CLIN ONCOL, V30, P3687, DOI 10.1200/JCO.2012.41.7238
   Qaseem A, 2016, ANN INTERN MED, V165, P125, DOI 10.7326/M15-2175
   Salwen JK, 2017, SLEEP, V40, DOI 10.1093/sleep/zsw064
   Savard J., 2021, J CLIN ONCOL, V19, P908
   Savard J, 2011, J CLIN ONCOL, V29, P3580, DOI 10.1200/JCO.2010.33.2247
   Savard MH, 2005, PSYCHO-ONCOLOGY, V14, P429, DOI 10.1002/pon.860
   Sela Rami A, 2005, Palliat Support Care, V3, P23
   Shaffer KM, 2020, J BEHAV MED, V43, P503, DOI 10.1007/s10865-019-00065-w
   Theobald Dale E, 2004, Clin Cornerstone, V6 Suppl 1D, pS15, DOI 10.1016/S1098-3597(05)80003-1
   Toivonen KI, 2021, CANCERS, V13, DOI 10.3390/cancers13010107
   van den Beuken-van Everdingen MHJ, 2016, J PAIN SYMPTOM MANAG, V51, P1070, DOI 10.1016/j.jpainsymman.2015.12.340
   Yin X, 2017, SLEEP MED, V37, P193, DOI 10.1016/j.sleep.2017.02.012
   Yusufov M., 2011, BREAST CANCER RES TR, V185, P62
   Zia FZ., 2017, JNCI MONOGR, V52
NR 48
TC 22
Z9 24
U1 0
U2 23
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2374-4677
J9 NPJ BREAST CANCER
JI npj Breast Cancer
PD NOV 30
PY 2021
VL 7
IS 1
AR 148
DI 10.1038/s41523-021-00355-0
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA XF6RL
UT WOS:000724196900001
PM 34848737
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Cherniack, EP
   Govorushko, S
AF Cherniack, E. Paul
   Govorushko, Sergey
TI To bee or not to bee: The potential efficacy and safety of bee venom
   acupuncture in humans
SO TOXICON
LA English
DT Review
DE Efficacy; Safety; Bee venom acupuncture
ID NEUROPATHIC COLD ALLODYNIA; ACUPOINT STIMULATION; FOS EXPRESSION;
   FORMALIN TEST; CANCER CELLS; PAIN; MELITTIN; PHARMACOPUNCTURE;
   APIPUNCTURE; INJECTION
AB Bee venom acupuncture is a form of acupuncture in which bee venom is applied to the tips of acupuncture needles, stingers are extracted from bees, or bees are held with an instrument exposing the stinger, and applied to acupoints on the skin. Bee venom is a complex substance consisting of multiple anti-inflammatory compounds such as melittin, adolapin, apamin. Other substances such as phospholipase A2 can be anti-inflammatory in low concentrations and pro-inflammatory in others. However, bee venom also contains proinflammatory substances, melittin, mast cell degranulation peptide 401, and histamine.
   Nevertheless, in small studies, bee venom acupuncture has been used in man to successfully treat a number of musculoskeletal diseases such as lumbar disc disease, osteoarthritis of the knee, rheumatoid arthritis, adhesive capsulitis, and lateral epicondylitis. Bee venom acupuncture can also alleviate neurological conditions, including peripheral neuropathies, stroke and Parkinson's Disease. The treatment has even been piloted in one series to alleviate depression.
   An important concern is the safety of bee venom. Bee venom can cause anaphylaxis, and several deaths have been reported in patients who successfully received the therapy prior to the adverse event. While the incidence of adverse events is unknown, the number of published reports of toxicity is small. Refining bee venom to remove harmful substances may potentially limit its toxicity.
   New uses for bee venom acupuncture may also be considered.
C1 [Cherniack, E. Paul] Univ Miami, Miller Sch Med, Miami VA Med Ctr, Div Geriatr & Palliat Med, Miami, FL 33136 USA.
   [Govorushko, Sergey] Russian Acad Sci, Pacific Geog Inst, Vladivostok, Russia.
   [Govorushko, Sergey] Far Eastern Fed Univ, Vladivostok, Russia.
C3 University of Miami; Russian Academy of Sciences; Pacific Geographical
   Institute of the Far Eastern Branch of the Russian Academy of Sciences;
   Far Eastern Federal University
RP Cherniack, EP (corresponding author), Miami VA Med Ctr, Room NH445,1201 NW 16 St, Miami, FL 33125 USA.
EM evan.cherniack@va.gov
CR Abdulsalam MA, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1091-3
   Ahn YJ, 2016, J ETHNOPHARMACOL, V194, P774, DOI 10.1016/j.jep.2016.11.012
   An H.J., 2016, Molecules, V21
   Bogdanov S., 2017, BEE VENOM COMPOSITIO
   Cai M, 2015, TOXINS, V7, P846, DOI 10.3390/toxins7030846
   Chae WY, 2015, ALLERGY ASTHMA RESPI, V3, P151, DOI 10.4168/aard.2015.3.2.151
   Chen HS, 2010, BRAIN RES, V1355, P61, DOI 10.1016/j.brainres.2010.08.002
   Cherniack EP, 2010, ALTERN MED REV, V15, P124
   Cho SY, 2018, J ALTERN COMPLEM MED, V24, P25, DOI 10.1089/acm.2016.0250
   Cho SY, 2013, COMPLEMENT THER MED, V21, P155, DOI 10.1016/j.ctim.2013.02.001
   Cho SY, 2014, CLIN INFECT DIS, V58, pE110, DOI 10.1093/cid/cit753
   Choi J, 2017, TOXINS, V9, DOI 10.3390/toxins9110351
   de Souza RN, 2017, J ACUPUNCT MERIDIAN, V10, P204, DOI 10.1016/j.jams.2017.04.003
   Doo KH, 2015, J ALTERN COMPLEM MED, V21, P598, DOI 10.1089/acm.2015.0078
   El-Wahab S.D.A., 2015, IOSR J Nurs Health Sci, V4, P19
   Fratini F, 2017, TOXICON, V130, P91, DOI 10.1016/j.toxicon.2017.02.020
   Huh JE, 2018, ALTERN THER HEALTH M, V24, P28
   Huh SY, 2008, ANN GERIATR MED RES, V12, P50
   Ip SW, 2008, IN VIVO, V22, P237
   Jin Z, 2018, J IMMUNOL RES, V2018, DOI 10.1155/2018/5038172
   Jo M, 2012, TOXICOL APPL PHARM, V258, P72, DOI 10.1016/j.taap.2011.10.009
   Jo N, 2015, J PHARMACOPUNCT, V18, P59, DOI 10.3831/KPI.2015.18.039
   Jung JW, 2012, ALLERGY ASTHMA IMMUN, V4, P107, DOI 10.4168/aair.2012.4.2.107
   Jung S, 2014, J PHARMACOPUNCT, V17, P22, DOI 10.3831/KPI.2014.17.033
   Kang SY, 2015, TOXINS, V7, P2571, DOI 10.3390/toxins7072571
   Karakurt F, 2010, J INVEST ALLERG CLIN, V20, P431
   KARAPATA A P, 1961, Klin Med (Mosk), V39, P142
   Kim HW, 2005, PHARMACOL RES, V51, P183, DOI 10.1016/j.phrs.2004.07.011
   Kim J.O.S.B., 2007, KOR J NEPHROL, V26, P1237
   Kim KW, 2011, BRAIN RES BULL, V84, P61, DOI 10.1016/j.brainresbull.2010.10.002
   Kim W, 2016, TOXINS, V8, DOI 10.3390/toxins8020033
   Kwon YB, 2004, MOL CELLS, V17, P329
   Kwon YB, 2001, PAIN, V90, P271, DOI 10.1016/S0304-3959(00)00412-7
   Lee HJ, 2015, INTERNAL MED, V54, P975, DOI 10.2169/internalmedicine.54.2238
   Lee JH, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-471
   Lee JA, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-006140
   Lee MJ, 2016, MOL NEUROBIOL, V53, P1977, DOI 10.1007/s12035-015-9131-4
   Lee MS, 2008, J PAIN, V9, P289, DOI 10.1016/j.jpain.2007.11.012
   Lee NR, 2013, INDIAN J DERMATOL VE, V79, DOI 10.4103/0378-6323.113113
   Lee SH, 2012, J PHARMACOPUNCT, V15, P7, DOI 10.3831/KPI.2012.15.011
   Lee SH., 2003, Journal of Acupuncture Research, V20, P80
   Lee SH, 2015, TOXINS, V7, P2835, DOI 10.3390/toxins7082835
   Lim BS, 2013, EVID-BASED COMPL ALT, V2013, DOI DOI 10.1155/2013/36932424058370
   Lim C, 2014, J PHARMACOPUNCT, V17, P74, DOI 10.3831/KPI.2014.17.030
   Lin L, 2017, BIOMED PHARMACOTHER, V90, P921, DOI 10.1016/j.biopha.2017.04.055
   Liu SJ, 2008, HEPATOLOGY, V47, P1964, DOI 10.1002/hep.22240
   Moga MA, 2018, MOLECULES, V23, DOI 10.3390/molecules23030692
   Mohseni-Kouchesfahani H, 2017, J CANCER RES THER, V13, P544, DOI 10.4103/0973-1482.183220
   OCONNOR R, 1980, J CHEM EDUC, V57, P206, DOI 10.1021/ed057p206
   Park JW, 2012, INTEGR CANCER THER, V11, P166, DOI 10.1177/1534735411413265
   Park JH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126971
   Park JH, 2000, J KOREAN NEUROL ASS, V18, P356
   Park JS, 2017, ANN REHABIL MED-ARM, V41, P483, DOI 10.5535/arm.2017.41.3.483
   Park MH, 2011, PROSTATE, V71, P801, DOI 10.1002/pros.21296
   Park SM, 2016, INT J DERMATOL, V55, P757, DOI 10.1111/ijd.12914
   Park YC, 2014, J ALTERN COMPLEM MED, V20, P919, DOI 10.1089/acm.2014.0220
   Pijak M, 2011, HEPATOL INT, V5, P104
   Rady I, 2017, CANCER LETT, V402, P16, DOI 10.1016/j.canlet.2017.05.010
   Ren X.H., 2004, J CLIN ACUPUNCT MOXI, V20, P54
   Rhee DY, 2009, CLIN EXP DERMATOL, V34, pE18, DOI 10.1111/j.1365-2230.2008.03149.x
   Roh DH, 2004, J PAIN, V5, P297, DOI 10.1016/j.jpain.2004.05.003
   Safaeinejad Z, 2013, J VENOM ANIM TOXINS, V19, DOI 10.1186/1678-9199-19-25
   Seo BK, 2017, TOXINS, V9, DOI 10.3390/toxins9110361
   Sur B, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1019-y
   Tsai LC, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/363801
   Vazquez-Revuelta P, 2018, J INVEST ALLERG CLIN, V28, P45, DOI 10.18176/jiaci.0202
   Yeo JH, 2016, J PAIN, V17, P298, DOI 10.1016/j.jpain.2015.10.018
   Yoon H, 2015, BIOL PHARM BULL, V38, P710, DOI 10.1248/bpb.b14-00797
   Yoon J, 2012, J ACUPUNCT MERIDIAN, V5, P156, DOI [10.1016/j.jams.2012.05.003, 10.106/j.jams.2012.05.003]
   Yoon SY, 2009, J PAIN, V10, P253, DOI 10.1016/j.jpain.2008.09.002
   Zhang S, 2018, TOXICON, V148, P64, DOI 10.1016/j.toxicon.2018.04.012
   Zhang SF, 2017, MOL MED REP, V16, P3581, DOI 10.3892/mmr.2017.6970
   Zhao MD, 2016, Journal of Traditional Chinese Medical Sciences, V3, P256, DOI [10.1016/j.jtcms.2016.09.005, 10.1016/j.jtcms.2016.09.005, DOI 10.1016/J.JTCMS.2016.09.005]
   Zhong Shan, 2005, Zhonghua Gan Zang Bing Za Zhi, V13, P831
NR 74
TC 64
Z9 72
U1 2
U2 79
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0041-0101
J9 TOXICON
JI Toxicon
PD NOV
PY 2018
VL 154
BP 74
EP 78
DI 10.1016/j.toxicon.2018.09.013
PG 5
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA GZ2TS
UT WOS:000449241900010
PM 30268393
DA 2026-01-16
ER

PT J
AU Liu, T
   Zhi, WQ
   Wang, XQ
   Pei, Q
   Guo, XF
   Huang, Q
AF Liu, Tong
   Zhi, Wenqian
   Wang, Xiaoquan
   Pei, Qian
   Guo, Xianfeng
   Huang, Qiang
TI Effectiveness of Fu's subcutaneous needling on pain and physical
   function in patients with knee osteoarthritis: A systematic review and
   meta-analysis
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Fu's subcutaneous needling; Knee osteoarthritis; Inflammatory cytokines;
   Randomized controlled trials; Pain assessment; Meta-analysis
ID RANDOMIZED CONTROLLED-TRIALS; VAGAL MODULATION; ACUPUNCTURE
AB Objectives This study aims to evaluate the efficacy of Fu's subcutaneous needling (FSN) for knee osteoarthritis (KOA) via a meta-analysis. Methods Randomized controlled trials (RCTs) of FSN for KOA were searched in PubMed, Cochrane Library, Embase, Web of Science, and other databases up to July 20, 2024. Stata 15.0 was leveraged for data analysis. Results 30 RCTs were included, involving 2169 individuals. Compared to electroacupuncture, acupuncture, and other therapies, FSN demonstrated significant benefits in reducing the Western Ontario and McMaster Universities Arthritis Index score (WOMAC, improved physical function) [SMD= -1.69 (-2.15 to -1.23), I-2 = 89.8 %, P < 0.001] and relieving pain (the visual analog scale) [SMD = -1.77( -2.14 to -1.40); I-2 = 89.8 %, P < 0.001]. Additionally, FSN was more effective in reducing inflammatory cytokine levels, such as interleukin 1 beta [SMD = -1.65 (-2.36, -0.94); I-2 = 91.9 %, P < 0.001], interleukin-6 [SMD = -3.93 (-5.08, -2.78); I-2 = 96.7 %, P < 0.001], and tumor necrosis factor-alpha [SMD = -2.65 (-3.46, -1.83); I-2 = 94.8 %, P < 0.001], and increasing the total effective rate [OR = 4.17, 95 % CI: 3.05-5.68; I-2 = 0.0 %, P < 0.001]. Conclusions FSN shows promise as an adjuvant therapy for KOA, with moderate-quality evidence supporting its short-term efficacy in pain relief and functional improvement. Further validation through standardized protocols is required to determine its long-term benefits.
C1 [Liu, Tong; Zhi, Wenqian; Wang, Xiaoquan; Pei, Qian; Guo, Xianfeng; Huang, Qiang] Capital Med Univ, Beijing Jishuitan Hosp, Dept Rehabil Med, 31 Xinjiekou East St, Beijing, Peoples R China.
C3 Capital Medical University
RP Huang, Q (corresponding author), Capital Med Univ, Beijing Jishuitan Hosp, Dept Rehabil Med, 31 Xinjiekou East St, Beijing, Peoples R China.
EM hq2349@vip.sina.com
FU Beijing Municipal Administration of Hospitals Incubating Program
   [PX2024018]
FX This research was supported by Beijing Municipal Administration of
   Hospitals Incubating Program (PX2024018)
CR Ali N, 2022, MOL CELL PROTEOMICS, V21, DOI 10.1016/j.mcpro.2022.100200
   Angst F, 2018, RMD OPEN, V4, DOI 10.1136/rmdopen-2018-000685
   Bassi GS, 2020, NEUROSCI BIOBEHAV R, V112, P363, DOI 10.1016/j.neubiorev.2020.02.011
   Bjarnason I, 2018, GASTROENTEROLOGY, V154, P500, DOI 10.1053/j.gastro.2017.10.049
   Chen J, 2023, Mod Drug Appl China, V17
   Chen P, 2021, Chin Pharm Sci, V11, P195
   Chen Q, 2021, Shenzhen J Integr Med, V31, P73, DOI [10.16458/j.cnki.1007-0893.2021.10.033, DOI 10.16458/J.CNKI.1007-0893.2021.10.033]
   Cheng J, 2022, Liaoning J Chin Med, V49
   Chiu PE, 2024, TRANSL RES, V273, P46, DOI 10.1016/j.trsl.2024.06.005
   Chiu PE, 2022, J CLIN MED, V11, DOI 10.3390/jcm11237184
   Dong W, 2023, Jilin Chin Med, V43, P1480, DOI [10.13463/j.cnki.jlzyy.2023.12.026, DOI 10.13463/J.CNKI.JLZYY.2023.12.026]
   Dworkin RH, 2008, J PAIN, V9, P105, DOI 10.1016/j.jpain.2007.09.005
   Fu ZH, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/353916
   Gelber AC, 2024, ANN INTERN MED, V177, DOI 10.7326/ANNALS-24-01249
   Gong M, 2025, Chin Acupunct Moxibustion, V45, P13
   Hauck M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13633-4
   Hayashi D, 2025, OSTEOARTHR CARTILAGE, V33, P88, DOI 10.1016/j.joca.2024.10.009
   Hayashi D, 2022, THER ADV MUSCULOSKEL, V14, DOI 10.1177/1759720X221146621
   Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928
   Huang CH, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/5951327
   Huang D, 2021, Chin Natl Health Med, V33, P110
   Huang Z, 2020, Inn Mong Tradit Chin Med, V39, P104, DOI [10.16040/j.cnki.cn15-1101.2020.01.062, DOI 10.16040/J.CNKI.CN15-1101.2020.01.062]
   Hwang HS, 2015, INT J MOL SCI, V16, P26035, DOI 10.3390/ijms161125943
   Irimes MB, 2024, MED RES REV, V44, P23, DOI 10.1002/med.21978
   Ji M, 2021, Chin Folk Rem, V29, P35, DOI [10.19621/j.cnki.11-3555/r.2021.0715, DOI 10.19621/J.CNKI.11-3555/R.2021.0715]
   Jia L, 2022, Chin Pharm Sci, V12, P127
   Jiang Y, 2019, J Pract Chin Med, P870
   Kan HS, 2019, HONG KONG MED J, V25, DOI 10.12809/hkmj187600
   Katz N, 2021, PAIN, V162, P1935, DOI 10.1097/j.pain.0000000000002204
   Kolasinski SL, 2020, ARTHRITIS RHEUMATOL, V72, P220, DOI [10.1002/art.41142, 10.1002/acr.24131]
   Langevin HM, 2001, FASEB J, V15, P2275, DOI 10.1096/fj.01-0015hyp
   Lei L, 2020, Lab Med Clin, V17, P807
   Li H, 2022, Shanghai Acupunct Moxibustion J, V41, P907, DOI [10.13460/j.issn.1005-0957.2022.09.0907, DOI 10.13460/J.ISSN.1005-0957.2022.09.0907]
   Li YP, 2022, MOL PAIN, V18, DOI 10.1177/17448069221108717
   Liang J, 2025, FRONT NEUROL, V16, DOI [10.3389/fneur.2025.1509291, 10.3389/fneur.2025.1509291]
   Liu W, 2021, J PAIN RES, V14, P2209, DOI 10.2147/JPR.S315956
   Liu Z, 2020, WORLD J ACUPUNCT-MOX, V30, P29, DOI 10.1016/j.wjam.2020.02.001
   Long HB, 2022, ARTHRITIS RHEUMATOL, V74, P1172, DOI 10.1002/art.42089
   Malemud CJ, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030484
   Mou JJ, 2024, EXPLORE-NY, V20, P562, DOI 10.1016/j.explore.2023.12.015
   Niu Z, 2023, Shanghai Acupunct Moxibustion J, V42, P170, DOI [10.13460/j.issn.1005-0957.2023.02.0170, DOI 10.13460/J.ISSN.1005-0957.2023.02.0170]
   Page M.J., 2021, BMJ, V372, pn71, DOI [10.1136/bmj.n71, DOI 10.1136/BMJ.N71]
   Paz-González R, 2024, ANN RHEUM DIS, V83, P661, DOI 10.1136/ard-2023-225090
   Peng HN, 2021, ORTHOP SURG, V13, P1465, DOI 10.1111/os.13021
   Sheng G, 2022, Massage Rehabil Med, V13, P1, DOI [10.19787/j.issn.1008-1879.2022.02.001, DOI 10.19787/J.ISSN.1008-1879.2022.02.001]
   Sheu ML, 2021, NEUROSURGERY, V89, pE49, DOI 10.1093/neuros/nyab105
   Tang Hui, 2019, Chinese Medical Sciences Journal, V34, P147, DOI [10.24920/003466, 10.24920/003466]
   Taylor P, 2014, PAIN PRACT, V14, P599, DOI 10.1111/papr.12116
   Torres-Rosas R, 2014, NAT MED, V20, P291, DOI 10.1038/nm.3479
   Wang M, 2023, Guangming Chin Med, V38, P3173
   [王琼 Wang Qiong], 2024, [上海针灸杂志, Shanghai Journal of Acupuncture and Moxibustion], V43, P416
   Wang Z, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1309751
   Wen X, 2019, Inn Mong Tradit Chin Med, V38, P82, DOI [10.16040/j.cnki.cn15-1101.2019.06.054, DOI 10.16040/J.CNKI.CN15-1101.2019.06.054]
   Wietek J, 2024, NAT METHODS, V21, DOI 10.1038/s41592-024-02285-8
   Xiao B, 2019, Chin Med Clin Res, V11, P17
   Xie Y, 2020, J Aerosp Med, V31, P985
   Yang J, 2021, Pract Integr Chin West Med Clin, V21, P79, DOI [10.13638/j.issn.1671-4040.2021.12.038, DOI 10.13638/J.ISSN.1671-4040.2021.12.038]
   Yang XL, 2024, MEDICINE, V103, DOI 10.1097/MD.0000000000038274
   Yao Q, 2023, SIGNAL TRANSDUCT TAR, V8, DOI 10.1038/s41392-023-01330-w
   Zhai P, 2022, Yi Kang, V3, P124, DOI [10.12332/j.issn.2095-6525.2022.03.042, DOI 10.12332/J.ISSN.2095-6525.2022.03.042]
   Zhang D, 2020, J Hubei Univ Tradit Chin Med., V22, P96
   Zhang L, 2019, MEDIAT INFLAMM, V2019, DOI 10.1155/2019/2165918
   Zhang N, 2021, J PAIN RES, V14, P2369, DOI 10.2147/JPR.S319195
   Zhang Q, 2020, J Pract Chin Med, V34, P109, DOI [10.13729/j.issn.1671-7813.z20200793, DOI 10.13729/J.ISSN.1671-7813.Z20200793]
   Zhang Y, 2021, Med Food Ther Health, V19, P78
   Zheng J, 2022, World J Sleep Med, V9, P642
   Zhou D, 2020, Chin Disabil Med, V28, P56, DOI [10.13214/j.cnki.cjotadm.2020.22.037, DOI 10.13214/J.CNKI.CJOTADM.2020.22.037]
   Zhou Z, 2016, ACS BIOMATER SCI ENG, V2, P929, DOI 10.1021/acsbiomaterials.6b00021
   Zhu J, 2019, Guangming Chin Med, V34
NR 69
TC 0
Z9 0
U1 4
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD OCT
PY 2025
VL 93
AR 103233
DI 10.1016/j.ctim.2025.103233
EA AUG 2025
PG 27
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 7OF7Q
UT WOS:001575715100001
PM 40846208
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Enblom, A
   Lekander, M
   Hammar, M
   Johnsson, A
   Onelöv, E
   Ingvar, M
   Steineck, G
   Börjeson, S
AF Enblom, Anna
   Lekander, Mats
   Hammar, Mats
   Johnsson, Anna
   Onelov, Erik
   Ingvar, Martin
   Steineck, Gunnar
   Borjeson, Sussanne
TI Getting the Grip on Nonspecific Treatment Effects: Emesis in Patients
   Randomized to Acupuncture or Sham Compared to Patients Receiving
   Standard Care
SO PLOS ONE
LA English
DT Article
ID CHEMOTHERAPY-INDUCED NAUSEA; CANCER-PATIENTS; CONTROLLED-TRIAL; PAIN;
   PROPHYLAXIS; MULTICENTER; ACUPRESSURE; SICKNESS; P6
AB Background: It is not known whether or not delivering acupuncture triggers mechanisms cited as placebo and if acupuncture or sham reduces radiotherapy-induced emesis more than standard care.
   Methodology/Principal Findings: Cancer patients receiving radiotherapy over abdominal/pelvic regions were randomized to verum (penetrating) acupuncture (n = 109; 99 provided data) in the alleged antiemetic acupuncture point PC6 or sham acupuncture (n = 106; 101 provided data) performed with a telescopic non-penetrating needle at a sham point 2-3 times/week during the whole radiotherapy period. The acupuncture cohort was compared to a reference cohort receiving standard care (n = 62; 62 provided data). The occurrence of emesis in each group was compared after a mean dose of 27 Gray. Nausea and vomiting were experienced during the preceding week by 37 and 8% in the verum acupuncture group, 38 and 7% in the sham acupuncture group and 63 and 15% in the standard care group, respectively. The lower occurrence of nausea in the acupuncture cohort (verum and sham) compared to patients receiving standard care (37% versus 63%, relative risk (RR) 0.6, 95 % confidence interval (CI) 0.5-0.8) was also true after adjustment for potential confounding factors for nausea (RR 0.8, CI 0.6 to 0.9). Nausea intensity was lower in the acupuncture cohort (78% no nausea, 13% a little, 8% moderate, 1% much) compared to the standard care cohort (52% no nausea, 32% a little, 15% moderate, 2% much) (p = 0.002). The acupuncture cohort expected antiemetic effects from their treatment (95%). Patients who expected nausea had increased risk for nausea compared to patients who expected low risk for nausea (RR 1.6; Cl 1.2-2.4).
   Conclusions/Significance: Patients treated with verum or sham acupuncture experienced less nausea and vomiting compared to patients receiving standard care, possibly through a general care effect or due to the high level of patient expectancy.
C1 [Enblom, Anna; Borjeson, Sussanne] Linkoping Univ, Div Nursing Sci, Dept Med & Hlth Sci, Linkoping, Sweden.
   [Enblom, Anna] Vardal Inst, Lund, Sweden.
   [Enblom, Anna; Lekander, Mats; Ingvar, Martin] Karolinska Inst, Dept Clin Neurosci, Osher Ctr Integrat Med, Stockholm, Sweden.
   [Lekander, Mats] Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.
   [Hammar, Mats] Linkoping Univ, Dept Clin & Expt Med Obstet & Gynecol, Linkoping, Sweden.
   [Johnsson, Anna] Univ Lund Hosp, Dept Oncol, Div Physiotherapy, S-22185 Lund, Sweden.
   [Onelov, Erik; Steineck, Gunnar] Karolinska Inst, Dept Oncol, Div Clin Canc Epidemiol, Stockholm, Sweden.
   [Steineck, Gunnar] Sahlgrens Acad, Dept Oncol, Div Clin Canc Epidemiol, Gothenburg, Sweden.
   [Borjeson, Sussanne] Linkoping Univ Hosp, Ctr Surg & Oncol, S-58185 Linkoping, Sweden.
C3 Linkoping University; Karolinska Institutet; Stockholm University;
   Linkoping University; Lund University; Skane University Hospital;
   Karolinska Institutet; University of Gothenburg; Linkoping University
RP Enblom, A (corresponding author), Linkoping Univ, Div Nursing Sci, Dept Med & Hlth Sci, Linkoping, Sweden.
EM anna.enblom@ki.se
RI Hammar, Mats/R-7908-2019; Steineck, Gunnar/W-1515-2019
OI Johnsson, Anna/0000-0001-9347-5336; Ingvar, Martin/0000-0002-9041-5714;
   Börjeson, Sussanne/0000-0002-9786-7326; Steineck,
   Gunnar/0000-0002-0787-3969
FU Swedish Cancer Society; Vardal Institute; County Council of
   Ostergotland; University of Linkoping; Cancer and Traffic Injury Fund;
   Vardal Foundation for Health Care Sciences and Allergy Research;
   Vinnova; Swedish Strategic Research Foundation
FX This study was supported by The Swedish Cancer Society, The Vardal
   Institute, The County Council of Ostergotland, The University of
   Linkoping, Cancer and Traffic Injury Fund and The Vardal Foundation for
   Health Care Sciences and Allergy Research. Mats Lekander and Martin
   Ingvar are members of Stockholm Brain Institute funded by Vinnova and
   The Swedish Strategic Research Foundation. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR AGLIETTI L, 1990, CANCER CHEMOTH PHARM, V26, P239, DOI 10.1007/BF02897209
   [Anonymous], COCHRANE DATABASE SY
   Arving Cecilia, 2007, Cancer Nurs, V30, pE10, DOI 10.1097/01.NCC.0000270709.64790.05
   Börjeson S, 2002, J PAIN SYMPTOM MANAG, V24, P345, DOI 10.1016/S0885-3924(02)00543-2
   Borjeson S, 1997, CANCER NURS, V20, P260
   Dibble S L, 2000, Oncol Nurs Forum, V27, P41
   DUNDEE JW, 1989, J ROY SOC MED, V82, P268, DOI 10.1177/014107688908200508
   ENBLOM A, 2008, 1088 LINK U MED DISS
   Enblom A, 2009, SUPPORT CARE CANCER, V17, P23, DOI 10.1007/s00520-008-0445-x
   FEYER PC, 2009, SUPPORT CAR IN PRESS
   Goldman RH, 2008, CLIN J PAIN, V24, P211, DOI 10.1097/AJP.0b013e31815ec20f
   Haake M, 2007, ARCH INTERN MED, V167, P1892, DOI 10.1001/archinte.167.17.1892
   Higgins SC, 2007, SUPPORT CARE CANCER, V15, P171, DOI 10.1007/s00520-006-0113-y
   Hui KKS, 2005, NEUROIMAGE, V27, P479, DOI 10.1016/j.neuroimage.2005.04.037
   Kaptchuk TJ, 2008, BMJ-BRIT MED J, V336, P999, DOI 10.1136/bmj.39524.439618.25
   Linde K, 2007, PAIN, V128, P264, DOI 10.1016/j.pain.2006.12.006
   Lu Weidong, 2005, Semin Oncol Nurs, V21, P190, DOI 10.1016/j.soncn.2005.04.008
   Luebbert K, 2001, PSYCHO-ONCOLOGY, V10, P490, DOI 10.1002/pon.537
   Maranzano E, 1999, INT J RADIAT ONCOL, V44, P619, DOI 10.1016/S0360-3016(99)00055-3
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P3, DOI 10.1016/j.ctim.2006.07.005
   Myers Cynthia D, 2008, J Soc Integr Oncol, V6, P19
   Mystakidou K, 2006, MED ONCOL, V23, P251, DOI 10.1385/MO:23:2:251
   Pariente J, 2005, NEUROIMAGE, V25, P1161, DOI 10.1016/j.neuroimage.2005.01.016
   Park J., 1999, ACUPUNCT MED, V17, P110
   Price DD, 2008, ANNU REV PSYCHOL, V59, P565, DOI 10.1146/annurev.psych.59.113006.095941
   Roscoe JA, 2003, J PAIN SYMPTOM MANAG, V26, P731, DOI 10.1016/S0885-3924(03)00254-9
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   Shin YH, 2004, CANCER NURS, V27, P267, DOI 10.1097/00002820-200407000-00002
   Shun SC, 2008, SUPPORT CARE CANCER, V16, P1059, DOI 10.1007/s00520-007-0384-y
   Steineck G, 2006, ACTA ONCOL, V45, P421, DOI 10.1080/02841860600649293
   Streitberger K, 2003, CLIN CANCER RES, V9, P2538
   Xia Y. S., 2000, INT J CLIN ACUPUNCTU, V11, P145
   Young SD, 2007, IEEE T VIS COMPUT GR, V13, P422, DOI [10.1109/TVCG.2007.1041, 10.1109/TVCG.2007.1029]
   Zachariae R, 2007, PSYCHOTHER PSYCHOSOM, V76, P376, DOI 10.1159/000107566
NR 34
TC 31
Z9 33
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 23
PY 2011
VL 6
IS 3
AR e14766
DI 10.1371/journal.pone.0014766
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 740QW
UT WOS:000288810500001
PM 21448267
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Boyd, C
   Crawford, C
   Paat, CF
   Price, A
   Xenakis, L
   Zhang, WM
AF Boyd, Courtney
   Crawford, Cindy
   Paat, Charmagne F.
   Price, Ashley
   Xenakis, Lea
   Zhang, Weimin
CA Evidence Massage Therapy EMT
TI The Impact of Massage Therapy on Function in Pain Populations-A
   Systematic Review and Meta-Analysis of Randomized Controlled Trials:
   Part II, Cancer Pain Populations
SO PAIN MEDICINE
LA English
DT Review
DE Systematic Review; Meta-Analysis; Massage Therapy; Pain; Function;
   Health-Related Quality of Life
ID RAPID EVIDENCE ASSESSMENT; BREAST-CANCER; ACUPUNCTURE RESEARCH;
   INTERVENTIONS; WOMEN; AROMATHERAPY; MILITARY; MOOD; CARE
AB Purpose. Pain is multi-dimensional and may be better addressed through a holistic, biopsychosocial approach. Massage therapy is commonly practiced among patients seeking pain management; however, its efficacy is unclear. This systematic review and meta-analysis is the first to rigorously assess the quality of massage therapy research and evidence for its efficacy in treating pain, function-related and health-related quality of life in cancer populations.
   Methods. Key databases were searched from inception through February 2014. Eligible randomized controlled trials were assessed for methodological quality using the SIGN 50 Checklist. Meta-analysis was applied at the outcome level. A diverse steering committee interpreted the results to develop recommendations.
   Results. Twelve high quality and four low quality studies were subsequently included in the review. Results demonstrate massage therapy is effective for treating pain compared to no treatment [standardized mean difference (SMD) = -.20] and active (SMD = -0.55) comparators. Compared to active comparators, massage therapy was also found to be beneficial for treating fatigue (SMD = -1.06) and anxiety (SMD = -1.24).
   Conclusion. Based on the evidence, weak recommendations are suggested for massage therapy, compared to an active comparator, for the treatment of pain, fatigue, and anxiety. No recommendations were suggested for massage therapy compared to no treatment or sham control based on the available literature to date. This review addresses massage therapy safety, research challenges, how to address identified research gaps, and necessary next steps for implementing massage therapy as a viable pain management option for cancer pain populations.
C1 [Boyd, Courtney; Crawford, Cindy; Paat, Charmagne F.; Price, Ashley; Xenakis, Lea; Zhang, Weimin; Evidence Massage Therapy EMT] Samueli Inst, 1737 King St,Suite 600, Alexandria, VA 22314 USA.
RP Boyd, C (corresponding author), Samueli Inst, 1737 King St,Suite 600, Alexandria, VA 22314 USA.
EM cboyd@samueliinstitute.org
RI Crawford, Cindy/AAI-3891-2021
FU Massage Therapy Foundation, through the American Massage Therapy
   Association
FX Funding for this project was provided by the Massage Therapy Foundation,
   through the generous support of the American Massage Therapy
   Association.
CR Ahles TA, 1999, J PAIN SYMPTOM MANAG, V18, P157, DOI 10.1016/S0885-3924(99)00061-5
   [Anonymous], 1988, Statistical Power for the Behavioral Sciences, DOI DOI 10.4324/9780203771587
   [Anonymous], GUID DEV HDB
   [Anonymous], PAIN ASS SCREEN TOOL
   [Anonymous], BOD OF KNOWL
   [Anonymous], ENTR LEV AN PROJ
   [Anonymous], 2010, AFMS News Letter
   [Anonymous], PROM PAT REP OUTC ME
   [Anonymous], 2014, PAIN MED S
   Archie P, 2013, SUPPORT CARE CANCER, V21, P2609, DOI 10.1007/s00520-013-1841-4
   Billhult A, 2007, J ALTERN COMPLEM MED, V13, P53, DOI 10.1089/acm.2006.6049
   Boyd C, 2016, PAIN MED, V17, P1757, DOI 10.1093/pm/pnw101
   Broom AF, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-98
   Campeau Marie-Pierre, 2007, J Soc Integr Oncol, V5, P133, DOI 10.2310/7200.2007.018
   CLEELAND CS, 1994, NEW ENGL J MED, V330, P592, DOI 10.1056/NEJM199403033300902
   Coleman EA, 2011, CANCER NURS, V34, P219, DOI 10.1097/NCC.0b013e3181f9904d
   Collinge W, 2013, SUPPORT CARE CANCER, V21, P1405, DOI 10.1007/s00520-012-1682-6
   Costello RB, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-106
   Crawford C, 2016, PAIN MED, V17, P1353, DOI 10.1093/pm/pnw099
   Crawford Cindy, 2015, BMC Res Notes, V8, P631, DOI [10.1186/s13104-015-1604-z, 10.1186/s13104-015-1604-z]
   Dalal S, 2012, CANCER-AM CANCER SOC, V118, P3869, DOI 10.1002/cncr.26694
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Ernst E, 2009, SUPPORT CARE CANCER, V17, P333, DOI 10.1007/s00520-008-0569-z
   Everdingen MHJVDBV, 2007, ANN ONCOL, V18, P1437, DOI 10.1093/annonc/mdm056
   Ezzo J, 2007, J ALTERN COMPLEM MED, V13, P291, DOI 10.1089/acm.2006.6291
   Farrar JT, 2000, PAIN, V88, P287, DOI 10.1016/S0304-3959(00)00339-0
   FURLAN AD, 2002, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD001929
   Furlan AD, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/953139
   Haraldsson B, 2006, COCHRANE DB SYST REV, V3, P1
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Jane SW, 2011, PAIN, V152, P2432, DOI 10.1016/j.pain.2011.06.021
   Jho HJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105900
   Khiewkhern S, 2013, ASIAN PAC J CANCER P, V14, P3903, DOI 10.7314/APJCP.2013.14.6.3903
   Khorsan R, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/694804
   Kutner JS, 2008, ANN INTERN MED, V149, P369, DOI 10.7326/0003-4819-149-6-200809160-00003
   Lee C, 2012, SYST REV, V1, DOI 10.1186/2046-4053-1-46
   Lee MS, 2011, ANN ONCOL, V22, P1459, DOI 10.1093/annonc/mdr147
   Lee SH, 2015, INTEGR CANCER THER, V14, P297, DOI 10.1177/1534735415572885
   Lesage, 1999, Cancer Control, V6, P136
   Levy MH, 1996, NEW ENGL J MED, V335, P1124, DOI 10.1056/NEJM199610103351507
   Listing M, 2009, PSYCHO-ONCOLOGY, V18, P1290, DOI 10.1002/pon.1508
   MacPherson H, 2010, ACUPUNCT MED, V28, P83, DOI 10.1136/aim.2009.001370
   Margarit Cesar, 2012, J Pain Res, V5, P559, DOI 10.2147/JPR.S36428
   Moyer CA, 2004, PSYCHOL BULL, V130, P3, DOI 10.1037/0033-2909.130.1.3
   O'Mahony S, 2005, J PAIN SYMPTOM MANAG, V29, P446, DOI 10.1016/j.jpainsymman.2004.08.010
   Pan YQ, 2014, INT J CLIN ONCOL, V19, P829, DOI 10.1007/s10147-013-0635-5
   Post-White J, 2009, J PEDIATR ONCOL NURS, V26, P16, DOI 10.1177/1043454208323295
   Post-White Janice, 2003, Integr Cancer Ther, V2, P332, DOI 10.1177/1534735403259064
   Reyes-Gibby CC, 2013, J PAIN SYMPTOM MANAG, V46, P161, DOI 10.1016/j.jpainsymman.2012.07.019
   Rosen Jennifer, 2013, Adv Mind Body Med, V27, P12
   Russell NC, 2008, J ALTERN COMPLEM MED, V14, P209, DOI 10.1089/acm.2007.7176
   Sagar SM, 2008, CURR ONCOL, V15, P42, DOI 10.3747/co.2008.197
   Smith H, 2012, CNS DRUGS, V26, P509, DOI 10.2165/11630580-000000000-00000
   Soden K, 2004, PALLIATIVE MED, V18, P87, DOI 10.1191/0269216304pm874oa
   Syrjala KL, 2008, PAIN, V135, P175, DOI 10.1016/j.pain.2007.10.026
   Toth M, 2013, J ALTERN COMPLEM MED, V19, P650, DOI 10.1089/acm.2012.0466
   Weinrich S P, 1990, Appl Nurs Res, V3, P140, DOI 10.1016/S0897-1897(05)80135-1
   Wilkie D J, 2000, Hosp J, V15, P31
   Williams AF, 2002, EUR J CANCER CARE, V11, P254, DOI 10.1046/j.1365-2354.2002.00312.x
   York A, 2011, MED ACUPUNCT, V23, P229, DOI 10.1089/acu.2011.0843
   Zeno SA, 2013, MED SCI SPORT EXER, V45, P1369, DOI 10.1249/MSS.0b013e318285c1b9
NR 61
TC 63
Z9 77
U1 0
U2 28
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD AUG
PY 2016
VL 17
IS 8
BP 1553
EP 1568
DI 10.1093/pm/pnw100
PG 16
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anesthesiology; General & Internal Medicine
GA DZ1WQ
UT WOS:000385632800017
PM 27165967
OA Bronze
DA 2026-01-16
ER

PT J
AU Axelsson, CK
   Ballegaard, S
   Karpatschof, B
   Schousen, P
AF Axelsson, Christen K.
   Ballegaard, Soren
   Karpatschof, Benny
   Schousen, Peer
TI Pressure pain sensitivity as a marker for stress and pressure pain
   sensitivity-guided stress management in women with primary breast cancer
SO SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
LA English
DT Article
DE Acupuncture; acupressure; clinical stress score; EORTC questionnaire;
   HADS questionnaire; patient education; self-evaluated stress; SF 36
   questionnaire
ID ANGINA-PECTORIS; INTEGRATED REHABILITATION; ACUPUNCTURE-POINT; MENTAL
   STRESS; DEPRESSION; HEALTH; RISK; INTERVENTION; ALLOSTASIS; DISEASE
AB Objectives. To validate (1) Pressure Pain Sensitivity (PPS) as a marker for stress and (2) a PPS-guided intervention in women with primary Breast Cancer (BC). Methods. (1) A total of 58 women with BC were examined before and after 6 months of intervention. A control group of 165 women office employees was divided in a High Stress Group (HSG, n = 37) and a Low Stress Group (LSG, n = 128) to evaluate the association between PPS, questionnaire-related Quality of Life (QOL) and self-evaluated stress. (2) A PPS-guided stress management program (n = 40) was compared to a Psychosocial Group Intervention (PGI, n = 91) and no treatment (n = 86) with respect to a European Organization for Research and Treatment of Cancer (EORTC) questionnaire measured QOL. Results. (1) Resting PPS and changes in PPS during the intervention period correlated significantly to EORTC and Short Form 36 (SF 36) main scores: (all p < 0.05). Between BC, HSG and LSG there was a significant and positive correlation with respect to PPS, SF 36 main scores, depression, and clinical stress scores (all p < 0.05). However, the BC group scored significantly lower than both HSG and LSG (both p < 0.05) with respect to self-evaluated stress. (2) The PPS-guided intervention group improved EORTC main score, pain and nausea, when compared to the control groups (all p < 0.05). Conclusions. PPS was positively associated with QOL, which was in contrast to self-evaluated stress. PPS-guided intervention improved QOL in women with breast cancer.
C1 [Axelsson, Christen K.] Univ Copenhagen, Herlev Hosp, Dept Breast Surg, DK-2730 Herlev, Denmark.
   [Ballegaard, Soren] UllCare, Hellerup, Denmark.
   [Karpatschof, Benny] Univ Copenhagen, Inst Psychol, Copenhagen K, Denmark.
   [Schousen, Peer] Horsholm Hosp, Surg Ctr, Horsholm, Denmark.
C3 University of Copenhagen; Herlev & Gentofte Hospital; University of
   Copenhagen; University of Copenhagen
RP Axelsson, CK (corresponding author), Bakkevej 14B, DK-2830 Virum, Denmark.
EM cax@dadlnet.dk
OI Ballegaard, soeren/0000-0002-4253-6909
FU Danish Cancer Society; KID Foundation, Copenhagen, Denmark
FX The study received economic support from the Danish Cancer Society
   (www.cancer.dk) and the KID Foundation, Copenhagen, Denmark. The support
   is greatly appreciated. The economic support contributed to the salary
   of the following staff members: Psychologist Gitte H. Sommer gave
   technical support, Nette Vestergaard Olsen (M.D. and acupuncturist),
   Gisli Magnusson (Physiotherapist and acupuncturist), and Bernadette
   Ballegaard (psychotherapist and acupuncturist) conducted the treatment
   of the patients in the active group; Rikke Gronkjaer (Reg. Nurse)
   conducted all the PPS measurements. Their contributions are greatly
   acknowledged.
CR Andersen BL, 2008, CANCER-AM CANCER SOC, V113, P3450, DOI 10.1002/cncr.23969
   Andersen BL, 2004, J CLIN ONCOL, V22, P3570, DOI 10.1200/JCO.2004.06.030
   Andersen SR, 2013, ACTA ONCOL, V52, P336, DOI 10.3109/0284186X.2012.745948
   [Anonymous], 2006, AM J MED
   BALLEGAARD S, 1991, J INTERN MED, V229, P357, DOI 10.1111/j.1365-2796.1991.tb00359.x
   Ballegaard S, 2004, J ALTERN COMPLEM MED, V10, P777
   BALLEGAARD S, 1995, ACUPUNCTURE ELECTRO, V20, P101, DOI 10.3727/036012995816357113
   BALLEGAARD S, 1993, ACUPUNCTURE ELECTRO, V18, P103, DOI 10.3727/036012993816357548
   Ballegaard S, 2009, SCAND J CLIN LAB INV, V69, P713, DOI 10.1080/00365510903042734
   Ballegaard S, 2014, SCAND J CLIN LAB INV, V74, P116, DOI 10.3109/00365513.2013.862847
   Ballegaard S, 2012, SCAND J CLIN LAB INV, V72, P459, DOI 10.3109/00365513.2012.695023
   BCoTC M, 1980, ESS CHIN AC
   Bergmann N, 2013, SCAND J CLIN LAB INV, V73, P373, DOI 10.3109/00365513.2013.785588
   BJORNER JB, 1997, DANISH MANUAL SF 36
   Boesen EH, 2011, EUR J CANCER, V47, P1363, DOI 10.1016/j.ejca.2011.01.002
   Boles M, 2004, J OCCUP ENVIRON MED, V46, P737, DOI 10.1097/01.jom.0000131830.45744.97
   Bredal IS, 2013, CANC NURS, V2013
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Christensen S, 2009, BREAST CANCER RES TR, V113, P339, DOI 10.1007/s10549-008-9920-9
   DUNDEE JW, 1991, J ROY SOC MED, V84, P210, DOI 10.1177/014107689108400409
   Ekman R., 2002, Stress, P69
   Ezzo J, 2006, J ALTERN COMPLEM MED, V12, P489, DOI 10.1089/acm.2006.12.489
   Folkow B, 2001, SCAND CARDIOVASC J, V35, P163, DOI 10.1080/140174301750305036
   Goetzel RZ, 2009, J OCCUP ENVIRON MED, V51, P487, DOI 10.1097/JOM.0b013e31819eb902
   Holmes SD, 2006, PROG CARDIOVASC DIS, V49, P106, DOI 10.1016/j.pcad.2006.08.013
   Hsieh LLC, 2006, BMJ-BRIT MED J, V332, P696, DOI 10.1136/bmj.38744.672616.AE
   Karasek R, 2006, Med Lav, V97, P258
   Kendler KS, 2000, AM J PSYCHIAT, V157, P1243, DOI 10.1176/appi.ajp.157.8.1243
   Korte SM, 2005, NEUROSCI BIOBEHAV R, V29, P3, DOI 10.1016/j.neubiorev.2004.08.009
   Loeppke R, 2009, J OCCUP ENVIRON MED, V51, P411, DOI 10.1097/JOM.0b013e3181a39180
   Magnusson G, 2010, J ALTERN COMPLEM MED, V16, P369, DOI 10.1089/acm.2009.0097
   Matsubara T, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1155/2011/543291
   McEwen Bruce S, 2006, Dialogues Clin Neurosci, V8, P367
   McEwen BS, 2004, ANN NY ACAD SCI, V1032, P1, DOI 10.1196/annals.1314.001
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Montazeri Ali, 2004, Asian Pac J Cancer Prev, V5, P316
   Montazeri A, 2008, BMC CANCER, V8, DOI [10.1186/1471-2407-8-330, 10.1186/1471-2393-8-12]
   Moraska A, 2010, EVID-BASED COMPL ALT, V7, P409, DOI 10.1093/ecam/nen029
   Nielsen NR, 2005, BRIT MED J, V331, P548, DOI 10.1136/bmj.38547.638183.06
   Noble RE, 2002, METABOLISM, V51, P37, DOI 10.1053/meta.2002.33190
   Oosterhuis WP, 2004, CLIN CHEM, V50, P806, DOI 10.1373/clinchem.2003.025528
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Raghavendra RM, 2009, INTEGR CANCER THER, V8, P37, DOI 10.1177/1534735409331456
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   SNAITH RP, 1986, BRIT MED J, V292, P344, DOI 10.1136/bmj.292.6516.344
   Stansfeld SA, 1998, PSYCHOSOM MED, V60, P247, DOI 10.1097/00006842-199805000-00004
   Wannamethee SG, 2005, ARCH INTERN MED, V165, P2644, DOI 10.1001/archinte.165.22.2644
   Würtzen H, 2013, EUR J CANCER, V49, P1365, DOI 10.1016/j.ejca.2012.10.030
NR 48
TC 5
Z9 6
U1 0
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5513
EI 1502-7686
J9 SCAND J CLIN LAB INV
JI Scand. J. Clin. Lab. Invest.
PD AUG
PY 2014
VL 74
IS 5
BP 399
EP 407
DI 10.3109/00365513.2014.900187
PG 9
WC Medical Laboratory Technology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; Research & Experimental Medicine
GA AN2QA
UT WOS:000340429200005
PM 24697620
DA 2026-01-16
ER

PT J
AU Wang, Y
   Yan, TQ
   Mu, XJ
   Dong, H
   Su, JM
AF Wang, Yan
   Yan, Tingquan
   Mu, Xiaojing
   Dong, Hong
   Su, Jinman
TI RETRACTED: Effects of Moxibustion Combined with Ultrashort Wave on Pain
   and Oxidative Stress in Elderly Patients with Knee Osteoarthritis
   (Retracted Article)
SO COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
LA English
DT Article; Retracted Publication
ID RESPONSIVENESS; RELIABILITY; VALIDITY
AB Objective. To explore the effect of moxibustion instrument combined with ultrashort wave on pain and oxidative stress in elderly patients with knee osteoarthritis (KOA). Method. 84 elderly patients with knee osteoarthritis treated in our hospital from May 2020 to June 2021 were randomly divided into observation group (n=42) and control group (n=42). The observation group was treated with moxibustion instrument combined with ultrashort wave, while the control group was treated with moxibustion instrument. The clinical efficacy of the two groups was compared, and the pain of the two groups was evaluated by visual analogue scale (VAS). Lysholm knee joint score scale and osteoarthritis index (WOMAC) scale of Western Ontario and McMaster University were used to evaluate the knee joint function of the two groups, and the levels of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), serum superoxide dismutase (SOD), serum malondialdehyde (MDA), serum miR-155, and NLRP3 were detected in the two groups, and the comprehensive quality of life assessment questionnaire-74 was used, and the adverse reactions were compared between the two groups. Results. The total effective rate of observation group (90.48%) was higher than that of control group (69.05%) (P < 0.05). After treatment, VAS, Lysholm knee joint, WOMAC, quality of life scores, IL-1 beta, TNF-alpha, SOD, MDA, miR-155, and NLRP3 in the observation group were better than those in the control group, and the differences were statistically significant (P < 0.05). There were no obvious adverse reactions in both groups. Conclusion. Moxibustion instrument combined with ultrashort wave can effectively improve knee joint pain, knee joint function, inflammatory reaction, oxidative stress reaction, and quality of life in elderly KOA patients, and the therapeutic effect is good.
C1 [Wang, Yan; Yan, Tingquan; Mu, Xiaojing; Dong, Hong] 971st Hosp, Outpatient Dept 1, Peoples Liberat Army Navy, Qingdao 266071, Shandong, Peoples R China.
   [Su, Jinman] Navy Qingdao Special Serv Convalescent Ctr, Ten Branches Recuperat, Qingdao 266071, Shandong, Peoples R China.
RP Yan, TQ (corresponding author), 971st Hosp, Outpatient Dept 1, Peoples Liberat Army Navy, Qingdao 266071, Shandong, Peoples R China.
EM 1203636806@qq.com; yantingquan0612@163.com; 108855689@qq.com;
   838341399@qq.com; 125383730@qq.com
RI Dong, Hongjie/ACJ-0166-2022
CR [Anonymous], 2007, OSTE BRANCH CHINESE
   Bing S., 2012, J NEUROSURG, V28, P645
   Chen Yu, 2020, Zhongguo Zhen Jiu, V40, P913, DOI [10.13703/j.0255-2930.20200310-k0011, 10.13703/j.0255-2930.20200310-k0011]
   Chen Yu, 2020, Zhen Ci Yan Jiu, V45, P569, DOI 10.13702/j.1000-0607.191015
   Fu W.J., 2020, ADV MODERN BIOMEDICI, V20, P5
   Jian-Hui Sun, 2020, Zhongguo Zhong Yao Za Zhi, V45, P4065, DOI 10.19540/j.cnki.cjcmm.20200608.203
   Kan HS, 2019, HONG KONG MED J, V25, DOI 10.12809/hkmj187600
   Kocher MS, 2004, J BONE JOINT SURG AM, V86A, P1139, DOI 10.2106/00004623-200406000-00004
   Li GS, 2021, EXP THER MED, V21, DOI 10.3892/etm.2020.9500
   Li SH, 2021, EUR REV MED PHARMACO, V25, P1185, DOI 10.26355/eurrev_202102_24821
   LiShumei W.Z, 2020, CONT NURSE 1 ISSUE, V27, P3
   Liu CX, 2020, ORTHOP SURG, V12, P286, DOI 10.1111/os.12586
   LiXiaojuan T., 2011, LIAONING J TRADITION, V38, P2
   Roos EM, 1999, SCAND J RHEUMATOL, V28, P210
   Scanzello CR, 2017, CURR OPIN RHEUMATOL, V29, P79, DOI 10.1097/BOR.0000000000000353
   Shen W, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/8204522
   Wang X, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019974
   Xiao YC, 2021, MOL MED REP, V23, DOI 10.3892/mmr.2020.11736
   Xu HF, 2018, TRIALS, V19, DOI 10.1186/s13063-018-2794-1
   Yildiz K, 2021, ACTA ORTHOP TRAUMATO, V55, P235, DOI 10.5152/j.aott.2021.19249
   Zhao LR, 2018, MOL MED REP, V17, P5463, DOI 10.3892/mmr.2018.8520
NR 21
TC 3
Z9 5
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1748-670X
EI 1748-6718
J9 COMPUT MATH METHOD M
JI Comput. Math. Method Med.
PD MAY 9
PY 2022
VL 2022
AR 3921021
DI 10.1155/2022/3921021
PG 7
WC Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Mathematical & Computational Biology
GA 1T8IG
UT WOS:000804969000004
PM 35586674
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Xue, YH
   Liu, F
   Huangfu, SH
   Jiang, YL
   Wang, XF
AF Xue, Yahong
   Liu, Fei
   Huangfu, Shaohua
   Jiang, Yunlin
   Wang, Xiaofeng
TI Electroacupuncture Treatment Alleviated Intracolonic Capsaicin-Induced
   Rectal Visceral Pain by Inhibiting the Expressions of TRPV1 and P2X4R
   and Blocking MAPK Pathway
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Article
DE rectal visceral pain; electroacupuncture; transient receptor potential
   vanilloid 1
AB Background: Electroacupuncture (EA) treatment can alleviate chronic neuropathic pain, like visceral pain, but the underlying mechanism remains unclear.Methods: Herein, rats were intracolonically injected with capsaicin to create a visceral (rectal) pain model. Then rats were treated with EA. The number of visceral pain-related behaviors, along with the mechanical pain thresholds of the rats' tail, metapedes and abdomen, were recorded. Meanwhile, the pathology of rectal tissue was observed by hematoxylin-eosin staining. The expressions of inflammatory factors (interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF-alpha)) and glial fibrillary acidic protein (GFAP) in the rat spinal cord or serum were assessed using enzyme-linked immunosorbent assay or Western blot. Likewise, the expression level of oxycocin-42 (OX42), GFAP, transient receptor potential vanilloid 1 (TRPV1), P2X4 receptor (P2X4R) and mitogen-activated protein kinase (MAPK) pathway-related proteins were determined by immunofluorescence or Western blot in the rats' spinal cord.Results: The increased visceral behavioral pain, mechanical pain threshold, secretion of inflammatory factors, edema of rectal mucosa and activation of spinal glial cells induced by capsaicin were all reversed by EA treatment. Additionally, the upregulation of TRPV1 and P2X4R as well as the activation of the MAPK pathway caused by capsaicin was offset by EA treatment.Conclusions: EA treatment ameliorates rats' rectal visceral pain by repressing TRPV1 and P2X4R expression levels as well as blocking MAPK pathway.
C1 [Xue, Yahong; Liu, Fei; Huangfu, Shaohua; Wang, Xiaofeng] Nanjing Univ Chinese Med, Proctol Dept, Nanjing Hosp Chinese Med, Nanjing 210000, Jiangsu, Peoples R China.
   [Jiang, Yunlin] Nanjing Univ Chinese Med, Surg Chinese Med, Nanjing Hosp Chinese Med, Nanjing 210000, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Xue, YH; Wang, XF (corresponding author), Nanjing Univ Chinese Med, Proctol Dept, Nanjing Hosp Chinese Med, Nanjing 210000, Jiangsu, Peoples R China.
EM wangxiaofe_wxf@163.com; xueyahong_1983@126.com
FU National Natural Science Foundation of China [82004362]
FX Funding This work was supported by National Natural Science Foundation
   of China, Role of P2X4 Receptor-mediated Spinal Microglia in the
   Mechanism of Electroacupunc-ture Treatment of Chronic Anorectal Pain
   [Grant Number: 82004362] .
CR Ali U, 2020, BIOMED PHARMACOTHER, V125, DOI 10.1016/j.biopha.2020.109898
   Baba K, 2021, NEUROSCI RES, V170, P273, DOI 10.1016/j.neures.2020.12.007
   Basso AR, 2021, J ETHNOPHARMACOL, V269, DOI 10.1016/j.jep.2020.113712
   Bujak JK, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.01087
   Du WB, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/8138017
   Feng B, 2020, J NEURAL TRANSM, V127, P415, DOI 10.1007/s00702-019-02088-8
   Fu R, 2021, NEUROSCI LETT, V750, DOI 10.1016/j.neulet.2021.135773
   Grundy L, 2019, ANNU REV PHYSIOL, V81, P261, DOI 10.1146/annurev-physiol-020518-114525
   Halievski K, 2020, J PHARMACOL EXP THER, V375, P202, DOI 10.1124/jpet.120.265017
   Hsu HC, 2019, ACUPUNCT MED, V37, P356, DOI 10.1136/acupmed-2017-011469
   Jiang GX, 2019, ACUPUNCT MED, V37, P116, DOI 10.1136/acupmed-2017-011559
   Jin X, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8828846
   Jin Y, 2021, ACUPUNCT MED, V39, P708, DOI 10.1177/09645284211020766
   Kelly RB, 2019, AM FAM PHYSICIAN, V100, P89
   King JL, 2021, PHARMACEUTICS, V13, DOI 10.3390/pharmaceutics13071053
   Leoni C, 2022, AM J MED GENET A, V188, P3287, DOI 10.1002/ajmg.a.62917
   Li YY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235917
   Li YH, 2019, J PAIN RES, V12, P2663, DOI 10.2147/JPR.S205987
   Liu YT, 2018, J MOL NEUROSCI, V66, P279, DOI 10.1007/s12031-018-1172-5
   Long T, 2020, J HEADACHE PAIN, V21, DOI 10.1186/s10194-019-1070-4
   Lucarini E, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9111671
   Matsui K, 2020, J PHARMACOL SCI, V143, P60, DOI 10.1016/j.jphs.2020.01.006
   Morales-Soto W, 2019, CELL MOL GASTROENTER, V7, P433, DOI 10.1016/j.jcmgh.2018.11.005
   Shi CX, 2017, MOL PAIN, V13, DOI 10.1177/1744806917725636
   Wang JY, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2134-8
   Wei TH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21134693
   Zhan MX, 2021, J PAIN RES, V14, P1201, DOI 10.2147/JPR.S303595
   Zhao JM, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/4956179
   Zhao YX, 2020, J PAIN RES, V13, P239, DOI 10.2147/JPR.S241101
   Zheng YY, 2021, MOL MED REP, V23, DOI 10.3892/mmr.2020.11814
NR 30
TC 1
Z9 1
U1 1
U2 4
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD SEP-OCT
PY 2022
VL 36
IS 5
BP 1369
EP 1378
DI 10.23812/j.biol.regul.homeost.agents.20223605.147
PG 10
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA C1RB3
UT WOS:000959762400001
OA hybrid
DA 2026-01-16
ER

PT J
AU Choi, HS
   Kang, SY
   Roh, DH
   Choi, SR
   Ryu, Y
   Lee, JH
AF Choi, Hoon-Seong
   Kang, Suk-Yun
   Roh, Dae-Hyun
   Choi, Sheu-Ran
   Ryu, Yeonhee
   Lee, Jang-Hern
TI Bee venom stimulation of a lung meridian acupoint reduces inflammation
   in carrageenan-induced pleurisy: an alternative therapeutic approach for
   respiratory inflammation
SO JOURNAL OF VETERINARY SCIENCE
LA English
DT Article
DE acupuncture; anti-inflammation; bee venoms; carrageenan-induced pleurisy
ID INDUCED PAW INFLAMMATION; WATER-SOLUBLE FRACTION; ANTIINFLAMMATORY
   DRUGS; RHEUMATOID-ARTHRITIS; MODEL; RATS; PAIN; ELECTROACUPUNCTURE;
   ACUPUNCTURE; ACTIVATION
AB Respiratory inflammation is a frequent and fatal pathologic state encountered in veterinary medicine. Although diluted bee venom (dBV) has potent anti-inflammatory effects, the clinical use of dBV is limited to several chronic inflammatory diseases. The present study was designed to propose an acupoint dBV treatment as a novel therapeutic strategy for respiratory inflammatory disease. Experimental pleurisy was induced by injection of carrageenan into the left pleural space in mouse. The dBV was injected into a specific lung meridian acupoint (LU-5) or into an arbitrary non-acupoint located near the midline of the back in mouse. The inflammatory responses were evaluated by analyzing inflammatory indicators in pleural exudate. The dBV injection into the LU-5 acupoint significantly suppressed the carrageenan-induced increase of pleural exudate volume, leukocyte accumulation, and myeloperoxidase activity. Moreover, dBV acupoint treatment effectively inhibited the production of interleukin 1 beta, but not tumor necrosis factor alpha in the pleural exudate. On the other hand, dBV treatment at non-acupoint did not inhibit the inflammatory responses in carrageenan-induced pleurisy. The present results demonstrate that dBV stimulation in the LU-5 lung meridian acupoint can produce significant anti-inflammatory effects on carrageenan-induced pleurisy suggesting that dBV acupuncture may be a promising alternative medicine therapy for respiratory inflammatory diseases.
C1 [Choi, Hoon-Seong; Choi, Sheu-Ran; Lee, Jang-Hern] Seoul Natl Univ, Res Inst Vet Sci, PLUS Program Creat Vet Sci Res BK21, Dept Vet Physiol, Seoul 08826, South Korea.
   [Choi, Hoon-Seong; Choi, Sheu-Ran; Lee, Jang-Hern] Seoul Natl Univ, Coll Vet Med, Seoul 08826, South Korea.
   [Kang, Suk-Yun; Ryu, Yeonhee] Korea Inst Oriental Med, KM Fundamental Res Div, Daejeon 34054, South Korea.
   [Roh, Dae-Hyun] Kyung Hee Univ, Sch Dent, Dept Oral Physiol, Seoul 02447, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Korea
   Institute of Oriental Medicine (KIOM); Kyung Hee University
RP Lee, JH (corresponding author), Seoul Natl Univ, Res Inst Vet Sci, PLUS Program Creat Vet Sci Res BK21, Dept Vet Physiol, Seoul 08826, South Korea.; Lee, JH (corresponding author), Seoul Natl Univ, Coll Vet Med, Seoul 08826, South Korea.; Ryu, Y (corresponding author), Korea Inst Oriental Med, KM Fundamental Res Div, Daejeon 34054, South Korea.
EM yhryu@kiom.re.kr; jhl1101@snu.ac.kr
RI ; Roh, Dae-Hyun/HPE-3599-2023
OI Choi, Sheu-Ran/0000-0001-8755-2024; Roh, Dae-Hyun/0000-0002-5139-5458
FU Korea Institute of Oriental Medicine (Daejeon, Republic of Korea)
   [K18181]
FX This research was supported by a grant (K18181) from the Korea Institute
   of Oriental Medicine (Daejeon, Republic of Korea).
CR Authier FJ, 1999, CELL DEATH DIFFER, V6, P1012, DOI 10.1038/sj.cdd.4400576
   Bhattacharyya S, 2011, AM J PHYSIOL-GASTR L, V301, pG475, DOI 10.1152/ajpgi.00071.2011
   Davies NM, 2004, J PHARM PHARM SCI, V7, P332
   Efthimiou P, 2010, RHEUMATOL INT, V30, P571, DOI 10.1007/s00296-009-1206-y
   Fuertes G, 2000, NEUROENDOCRINOLOGY, V71, P60, DOI 10.1159/000054521
   Gruber W, 2002, THORAX, V57, P222, DOI 10.1136/thorax.57.3.222
   Haegens A, 2008, EUR RESPIR J, V31, P252, DOI 10.1183/09031936.00029307
   Hajhashemi V, 2010, INFLAMM RES, V59, P1053, DOI 10.1007/s00011-010-0225-1
   Harirforoosh S, 2009, EXPERT OPIN DRUG SAF, V8, P669, DOI 10.1517/14740330903311023
   Kang SS, 2002, AM J CHINESE MED, V30, P73, DOI 10.1142/S0192415X02000089
   Kang SY, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/809062
   Kim HW, 2008, BRAIN RES BULL, V75, P698, DOI 10.1016/j.brainresbull.2007.11.015
   Kolber BJ, 2009, BRAIN RES, V1293, P85, DOI 10.1016/j.brainres.2009.03.061
   Kwon YB, 2005, PHARMACOL BIOCHEM BE, V80, P181, DOI 10.1016/j.pbb.2004.10.017
   Kwon YB, 2003, J NEUROENDOCRINOL, V15, P93, DOI 10.1046/j.1365-2826.2003.00951.x
   Kwon YB, 2002, LIFE SCI, V71, P191, DOI 10.1016/S0024-3205(02)01617-X
   Lee JD, 2005, EVID-BASED COMPL ALT, V2, P79, DOI 10.1093/ecam/neh070
   Lee JH, 2001, J VET MED SCI, V63, P251, DOI 10.1292/jvms.63.251
   Lee MS, 2008, J PAIN, V9, P289, DOI 10.1016/j.jpain.2007.11.012
   Li L, 2017, EVID-BASED COMPL ALT, V2017, P3162851
   Liu XY, 2004, EXP NEUROL, V189, P189, DOI 10.1016/j.expneurol.2004.05.028
   Loram LC, 2007, J PAIN, V8, P127, DOI 10.1016/j.jpain.2006.06.010
   Malhotra S, 2012, EXPERT OPIN THER TAR, V16, P195, DOI 10.1517/14728222.2012.661416
   Menegazzi M, 2008, PHARMACOL RES, V58, P22, DOI 10.1016/j.phrs.2008.05.012
   Nestor PJ, 2004, NAT MED, V10, pS34, DOI 10.1038/nrn1433
   Nicoletti F, 2010, AUTOIMMUN DIS, V2010, DOI 10.4061/2010/757432
   Ong CKS, 2007, CLIN MED RES, V5, P17, DOI 10.3121/cmr.2007.698
   Park HJ, 2008, J INFLAMM-LOND, V5, DOI 10.1186/1476-9255-5-7
   Roh DH, 2011, BRIT J PHARMACOL, V163, P1707, DOI 10.1111/j.1476-5381.2011.01316.x
   Saleh TSF, 1996, BRIT J PHARMACOL, V118, P811, DOI 10.1111/j.1476-5381.1996.tb15472.x
   Saleh TSF, 1999, PEPTIDES, V20, P949
   Son DJ, 2007, PHARMACOL THERAPEUT, V115, P246, DOI 10.1016/j.pharmthera.2007.04.004
   U.S. National Institutes of Health, 1985, Fed Regist, V50, P19584
   Vazquez E, 2015, INFLAMM RES, V64, P333, DOI 10.1007/s00011-015-0814-0
   Wu ZJ, 2016, MED ACUPUNCT, V28, P331, DOI 10.1089/acu.2016.1171
   Yin CS, 2008, RES VET SCI, V84, P159, DOI 10.1016/j.rvsc.2007.04.004
   Yoon SY, 2008, NEUROSCI LETT, V430, P163, DOI 10.1016/j.neulet.2007.10.035
   Yoon SY, 2007, NEUROSCI RES, V59, P51, DOI 10.1016/j.neures.2007.05.008
   ZIMMERMANN M, 1983, PAIN, V16, P109, DOI 10.1016/0304-3959(83)90201-4
NR 39
TC 8
Z9 9
U1 1
U2 8
PU KOREAN SOC VETERINARY SCIENCE
PI SEOUL
PA SEOUL NATL UNIV,  COLLEGE VETERINARY MEDICINE,, SEOUL, 151-742, SOUTH
   KOREA
SN 1229-845X
EI 1976-555X
J9 J VET SCI
JI J. Vet. Sci.
PD SEP
PY 2018
VL 19
IS 5
BP 708
EP 715
DI 10.4142/jvs.2018.19.5.708
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA GV2TS
UT WOS:000445944700016
PM 29929357
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Liu, NN
   Liu, GH
   Chang, XL
   Xu, YX
   Hou, Y
   Zhang, DB
   Wang, LZ
   Chen, SZ
AF Liu, Ningning
   Liu, Gaihong
   Chang, Xiaoli
   Xu, Yingxue
   Hou, Yi
   Zhang, Dongbin
   Wang, Lianzhu
   Chen, Shaozong
TI Combining various acupuncture therapies with multimodal analgesia to
   enhance postoperative pain management following total knee arthroplasty:
   a network meta-analysis of randomized controlled trials
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE acupuncture therapy; total knee arthroplasty (TKA); pain management;
   alternative therapies; network meta-analysis (NMA); randomized
   controlled trials
ID SYSTEMATIC REVIEWS; PLACEBO; OUTCOMES; OSTEOARTHRITIS; MODEL;
   ELECTROACUPUNCTURE; NEUROSCIENCE; REPLACEMENT; CANCER; PRISMA
AB Objective: This study aims to evaluate the efficacy and safety of various acupuncture treatments in conjunction with multimodal analgesia (MA) for managing postoperative pain and improving knee function in patients undergoing total knee arthroplasty (TKA), based on the findings from clinical research indicating the potential benefits of acupuncture-related therapies in this context. Methods: We searched Web of Science, PubMed, SCI-hub, Embase, Cochrane Library, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Data, and Chinese Scientific Journal Database (VIP) to collect randomized controlled trials of acupuncture-related therapies for post-TKA pain. After independent screening and data extraction, the quality of the included literature was evaluated. The potential for bias in the studies incorporated in the analysis was assessed according to the guidelines outlined in the Cochrane Handbook 5.1. Network meta-analysis (NMA) was conducted using RevMan 5.4 and Stata 16.0 software, with primary outcome measures including visual analog scale (VAS), pain pressure threshold (PPT), hospital for special surgery knee score (HSS), and knee joint range of motion (ROM). Furthermore, the interventions were ranked based on the SUCRA value. Results: We conducted an analysis of 41 qualifying studies encompassing 3,003 patients, examining the efficacy of four acupuncture therapies (acupuncture ACU, electroacupuncture EA, transcutaneous electrical acupoint stimulation TEAS, and auricular acupoint therapy AAT) in conjunction with multimodal analgesia (MA) and MA alone. The VAS results showed no significant difference in efficacy among the five interventions for VAS-3 score. However, TEAS+MA (SMD: 0.67; 95%CI: 0.01, 1.32) was more effective than MA alone for VAS-7 score. There was no significant difference in PPT score among the three interventions. ACU + MA (SMD: 6.45; 95%CI: 3.30, 9.60), EA + MA (SMD: 4.89; 95%CI: 1.46, 8.32), and TEAS+MA (SMD: 5.31; 95%CI: 0.85, 9.78) were found to be more effective than MA alone for HSS score. For ROM score, ACU + MA was more efficacious than EA + MA, TEAS+MA, and AAT + MA, MA. Regarding the incidence of postoperative adverse reactions, nausea and vomiting were more prevalent after using only MA. Additionally, the incidence of postoperative dizziness and drowsiness following ACU + MA (OR = 4.98; 95%CI: 1.01, 24.42) was observed to be higher compared to that after AAT + MA intervention. Similarly, the occurrence of dizziness and drowsiness after MA was found to be significantly higher compared to the following interventions: TEAS+MA (OR = 0.36; 95%CI: 0.18, 0.70) and AAT + MA (OR = 0.20; 95%CI: 0.08, 0.50). The SUCRA ranking indicated that ACU + MA, EA + MA, TEAS+MA, and AAT + MA displayed superior SUCRA scores for each outcome index, respectively. Conclusion: For the clinical treatment of post-TKA pain, acupuncture-related therapies can be selected as a complementary and alternative therapy. EA + MA and TEAS+MA demonstrate superior efficacy in alleviating postoperative pain among TKA patients. ACU + MA is the optimal choice for promoting postoperative knee joint function recovery in TKA patients. AAT + MA is recommended for preventing postoperative adverse reactions.
C1 [Liu, Ningning; Liu, Gaihong; Xu, Yingxue; Zhang, Dongbin; Wang, Lianzhu] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan, Shandong, Peoples R China.
   [Liu, Ningning; Hou, Yi] Shandong Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Jinan 250014, Shandong, Peoples R China.
   [Chang, Xiaoli; Chen, Shaozong] Shandong Univ Tradit Chinese Med, Res Inst Acupuncture & Moxibust, Jinan, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University of Traditional
   Chinese Medicine
RP Chen, SZ (corresponding author), Shandong Univ Tradit Chinese Med, Res Inst Acupuncture & Moxibust, Jinan, Shandong, Peoples R China.
EM ccsz1963@163.com
RI Liu, Ningning/JTS-4487-2023
FU Major Basic research of Natural Science Foundation of Shandong Province
   [ZR2020ZD17]; Youth Project of Natural Science Foundation of Shandong
   Province [ZR2023QH041]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was supported
   by the Major Basic research of Natural Science Foundation of Shandong
   Province (ZR2020ZD17) and Youth Project of Natural Science Foundation of
   Shandong Province (ZR2023QH041). The funding recipient SC was involved
   in conceptualizing, reviewing, and revising the manuscript. The funding
   recipient XC was also involved in the study design and data analysis.
CR Alciati A, 2021, CLIN EXP RHEUMATOL, V39, pS3, DOI [10.55563/clinexprheumatol/gz4i3i, 10.55563/clinexprheumatol/gz4i3i]
   [Anonymous], 2018, Global Action Plan on Physical Activity 2018-2030: More Active People for a Healthier World
   [Anonymous], 2014, CHIN J DIABETES, V22, P2, DOI DOI 10.3760/CMA.J.ISSN.1674-5809.2014.07.004
   Bingel U, 2008, PHYSIOLOGY, V23, P371, DOI 10.1152/physiol.00024.2008
   Bingxin K., 2022, Chinese J Integr Tradit Western Med, V42, P1169
   Breivik H, 2002, J PAIN SYMPTOM MANAG, V24, P97, DOI 10.1016/S0885-3924(02)00465-7
   Butcher NJ, 2022, JAMA-J AM MED ASSOC, V328, P2252, DOI 10.1001/jama.2022.21022
   Cai M, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1665-3
   Caixia G., 2020, Chinese Med Clin, V20, P2, DOI [10.11655/zgywylc2020.02.027, DOI 10.11655/ZGYWYLC2020.02.027]
   Chae Y, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00243
   Chaimani A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076654
   Chandrasekaran S, 2009, ANZ J SURG, V79, P526, DOI 10.1111/j.1445-2197.2009.04982.x
   Chao G., 2023, Clinical observation of electroacupuncture for pain after total knee arthroplasty
   Chen CC, 2015, REGION ANESTH PAIN M, V40, P31, DOI 10.1097/AAP.0000000000000138
   Chenghao M., 2021, Chinese J Tissue Eng Res, V25, P5798
   Cong-rui W., 2021, Chinese J Pharm Clin, V21, P3507, DOI [10.11655/zgywylc2021.21.002, DOI 10.11655/ZGYWYLC2021.21.002]
   Cook CE, 2023, FRONT PSYCHOL, V14, DOI 10.3389/fpsyg.2023.1178560
   Craig AD, 2011, ANN NY ACAD SCI, V1225, P72, DOI 10.1111/j.1749-6632.2011.05990.x
   Da C., 2019, Chinese J Acupunct Moxibustion, V39, P247, DOI [10.13703/j.0255-2930.2019.03.006, DOI 10.13703/J.0255-2930.2019.03.006]
   da Silva MD, 2015, MOL NEUROBIOL, V51, P19, DOI 10.1007/s12035-014-8790-x
   Dejin W., 2019, J Zhejiang Integr Tradit Western Med, V29, P2
   Dong S., 2018, Clinical efficacy analysis and experimental study of electroacupuncture on analgesia after total knee arthroplasty
   Eymir M, 2022, KNEE SURG SPORT TR A, V30, P2776, DOI 10.1007/s00167-021-06657-x
   Maistrello LF, 2023, Advances in Rehabilitation, V37, P40, DOI [10.5114/areh.2023.126056, 10.5114/areh.2023.126056, DOI 10.5114/AREH.2023.126056]
   Fang JQ, 2018, LIFE SCI, V200, P69, DOI 10.1016/j.lfs.2018.03.028
   Gang C., 2012, Chinese Acupunct, V32, P309, DOI [10.3969/j.issn.1672-7002.2006.07.017, DOI 10.3969/J.ISSN.1672-7002.2006.07.017]
   Garcia-Labbé D, 2015, CAN J CARDIOL, V31, DOI 10.1016/j.cjca.2014.12.008
   Geuter S, 2017, ANNU REV NEUROSCI, V40, P167, DOI 10.1146/annurev-neuro-072116-031132
   Gu L., 2022, Prog Psychol Sci, V30, P2518, DOI [10.3724/SP.J.1042.2022.02518, DOI 10.3724/SP.J.1042.2022.02518]
   Guiju D., 2020, Inner Mongolia J Tradit Chinese Med, V39, P108
   Haggard P, 2013, CURR BIOL, V23, pR164, DOI 10.1016/j.cub.2013.01.047
   Haiping Z., 2022, China Minkang Med, V34, P109
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   He BJ, 2013, PAIN MED, V14, P1608, DOI 10.1111/pme.12197
   Higgins J., 2008, COCHRANE HDB SYSTEMA
   Hong Z., 2020, Zhejiang J Integr Tradit Western Med, V30, P3
   Hudson TJ, 2017, PAIN, V158, P1039, DOI 10.1097/j.pain.0000000000000874
   Hutton B, 2015, ANN INTERN MED, V162, P777, DOI 10.7326/M14-2385
   Ip D., 2007, Orthopedic Rehabilitation, Assessment, and Enablement
   Jazaeri SZ, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192168
   Jeong HS, 2019, J ATHL TRAINING, V54, P418, DOI 10.4085/1062-6050-329-17
   Jiaqun Z., 2022, New Chin Med, V54, P192, DOI [10.13457/j.cnki.jncm.2022.07.045, DOI 10.13457/J.CNKI.JNCM.2022.07.045]
   Jinfa W., 2012, J TCM Bonesetting, V24, P4
   Jung WM, 2015, SCI REP-UK, V5, DOI 10.1038/srep12455
   Junteng Z., 2014, Study on the effect of electroacupuncture on pain and activity limitation after total knee arthroplasty
   Kahn TL, 2015, J ARTHROPLASTY, V30, P1521, DOI 10.1016/j.arth.2015.03.016
   Kean CO, 2017, CLIN BIOMECH, V42, P20, DOI 10.1016/j.clinbiomech.2017.01.002
   KEHLET H, 1993, ANESTH ANALG, V77, P1048
   Koog YH, 2016, COMPLEMENT THER MED, V24, P69, DOI 10.1016/j.ctim.2015.12.007
   Leung K, 2020, RADIOLOGY, V296, P584, DOI 10.1148/radiol.2020192091
   Li B., 2021, fMRI study on the brain effect mechanism of acupuncture at Taichong and Ligou groups
   Li D., 2022, Chinese Acupunct, V42, P13, DOI [10.13703/j.0255-2930.20210113-k0002, DOI 10.13703/J.0255-2930.20210113-K0002]
   Li L, 2007, PAIN MED, V8, P223, DOI 10.1111/j.1526-4637.2007.00296.x
   Li XY, 2023, MOL NEUROBIOL, V60, P6613, DOI 10.1007/s12035-023-03467-9
   Li YY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235917
   Liang L., 2020, Int J Tradit Chinese Med, V42, P5, DOI [10.3760/cma.j.cn115398-20190423-00155, DOI 10.3760/CMA.J.CN115398-20190423-00155]
   Liang Y., 2014, J Clin Tradit Chinese Med, V12, P2
   Longhini J, 2024, SPORTS MED-OPEN, V10, DOI 10.1186/s40798-024-00678-9
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Madry H, 2022, OSTEOARTHR CARTILAGE, V30, P1019, DOI 10.1016/j.joca.2022.01.012
   Meng ZY, 2023, ARCH ORTHOP TRAUM SU, V143, P409, DOI 10.1007/s00402-021-04326-9
   Menon V, 2010, BRAIN STRUCT FUNCT, V214, P655, DOI 10.1007/s00429-010-0262-0
   Mudumbai SC, 2016, KOREAN J ANESTHESIOL, V69, P32, DOI 10.4097/kjae.2016.69.1.32
   Nanavati Aditya J, 2014, Anesth Essays Res, V8, P127, DOI 10.4103/0259-1162.134474
   Nielsen A, 2020, PAIN MED, V21, P1276, DOI 10.1093/pm/pnz379
   Nielsen NI, 2022, BRIT J ANAESTH, V128, P150, DOI 10.1016/j.bja.2021.10.001
   Park JY, 2014, J PAIN, V15, P535, DOI 10.1016/j.jpain.2014.01.498
   Peijian T., 2010, Chinese J Integ Tradit Western Med, V30, P931
   Penghui Z., 2019, J Clin Anesthesiol, V3, P4
   Petersen T, 2018, PAIN MED, V19, P1280, DOI 10.1093/pm/pnx317
   Petrovic P, 2002, SCIENCE, V295, P1737, DOI 10.1126/science.1067176
   Piaopiao C., 2020, J Mod Integr Tradit Western Med, V29, P5, DOI [10.3969/j.issn.1008-8849.2020.31.009, DOI 10.3969/J.ISSN.1008-8849.2020.31.009]
   Piccoli Alessandro, 2018, J Funct Morphol Kinesiol, V3, DOI [10.3390/jfmk3030040, 10.3390/jfmk3030040]
   Pinto PR, 2013, J PAIN, V14, P502, DOI 10.1016/j.jpain.2012.12.020
   Pischon T, 2016, RECENT RESULTS CANC, V208, P1, DOI 10.1007/978-3-319-42542-9_1
   Qiao L, 2020, AM J CHINESE MED, V48, P245, DOI 10.1142/S0192415X20500135
   Remeniuk B, 2015, PAIN, V156, P1864, DOI 10.1097/j.pain.0000000000000218
   Rongzhen L., 2019, Chinese J Geriatr, V39, P3688, DOI [10.3969/j.issn.1005-9202.2019.15.028, DOI 10.3969/J.ISSN.1005-9202.2019.15.028]
   Rossettini G, 2022, FRONT PSYCHOL, V13, DOI 10.3389/fpsyg.2022.789377
   Rossettini G, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/2946465
   Rui L., 2023, Chinese Acupunct, V43, P427, DOI [10.13703/j.0255-2930.20221008-k0009, DOI 10.13703/J.0255-2930.20221008-K0009]
   Ruiting W., 2009, Qilu Med J, V24, P253
   Salanti G, 2011, J CLIN EPIDEMIOL, V64, P163, DOI 10.1016/j.jclinepi.2010.03.016
   Schafer SM, 2018, PROG NEUROBIOL, V160, P101, DOI 10.1016/j.pneurobio.2017.10.008
   Schreiber KL, 2020, J PAIN, V21, P294, DOI 10.1016/j.jpain.2019.08.008
   Sellmeijer J, 2018, J NEUROSCI, V38, P3102, DOI 10.1523/JNEUROSCI.3195-17.2018
   Sheng Z., 2021, Clinical efficacy and supraspinal mechanism of electroacupuncture for acute pain after total knee arthroplasty
   Shengjuan Z., 2015, Shanghai J Acupuncture Moxibust, V34, P3, DOI [10.13460/j.issn.1005-0957.2015.02.0134, DOI 10.13460/J.ISSN.1005-0957.2015.02.0134]
   Shuyi C., 2023, Chinese Acupunct, V43, P1118, DOI [10.13703/j.0255-2930.20221228-0002, DOI 10.13703/J.0255-2930.20221228-0002]
   Silva PKDD, 2023, J ARTHROPLASTY, V38, P281, DOI 10.1016/j.arth.2022.08.042
   Songpo S., 2018, Chin J Orthop, V38, P7, DOI [10.3760/cma.j.issn.0253-2352.2018.17.008, DOI 10.3760/CMA.J.ISSN.0253-2352.2018.17.008]
   Tang Yu-Long, 2017, Shengli Xuebao, V69, P637, DOI 10.13294/j.aps.2017.0055
   Taniguchi M, 2016, J ARTHROPLASTY, V31, P984, DOI 10.1016/j.arth.2015.11.012
   Tedesco D, 2017, JAMA SURG, V152, DOI 10.1001/jamasurg.2017.2872
   Tianyu B., 2023, Chinese J Tradit Chinese Med Inform, V30, P141, DOI [10.19879/j.cnki.1005-5304.202206544, DOI 10.19879/J.CNKI.1005-5304.202206544]
   Tsang RCC, 2007, CLIN REHABIL, V21, P719, DOI 10.1177/0269215507077362
   Tzeng CY, 2015, ACUPUNCT MED, V33, P284, DOI 10.1136/acupmed-2014-010722
   Váradi A, 2016, J MED CHEM, V59, P8381, DOI 10.1021/acs.jmedchem.6b00748
   Viceconti A, 2021, JOINT BONE SPINE, V88, DOI 10.1016/j.jbspin.2021.105153
   Viceconti A, 2020, FRONT HUM NEUROSCI, V14, DOI 10.3389/fnhum.2020.00083
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Wager TD, 2004, SCIENCE, V303, P1162, DOI 10.1126/science.1093065
   Wager TD, 2015, NAT REV NEUROSCI, V16, P403, DOI 10.1038/nrn3976
   Wand BM, 2013, BRIT J SPORT MED, V47, P1085, DOI 10.1136/bjsports-2013-092949
   Wang CL., 2019, Comparative study of total knee arthroplasty with and without preservation of posterior cruciate ligament
   Wang L., 2017, J Capital Med Univ, V38, P4, DOI [10.3969/j.issn.1006-7795.2017.06.026, DOI 10.3969/J.ISSN.1006-7795.2017.06.026]
   Wang XQ, 2019, BMC COMPLEM ALTERN M, V19, DOI 10.1186/s12906-019-2624-3
   Wang YL, 2023, EXP NEUROL, V362, DOI 10.1016/j.expneurol.2023.114324
   Wanlu L., 2021, J Mod Integr Tradit Western Med, DOI [10.3969/j.issn.1008-8849.2021.22.007, DOI 10.3969/J.ISSN.1008-8849.2021.22.007]
   Webber SC, 2017, MED SCI SPORT EXER, V49, P1057, DOI 10.1249/MSS.0000000000001207
   Weihua Z., 2023, Asia Pac J Tradit Med, V19, P88
   Weiwei K., 2020, West China J Tradit Chinese Med, DOI [10.12174/j.issn.1004-6852.2020.12.30, DOI 10.12174/J.ISSN.1004-6852.2020.12.30]
   Wenxing L., 2013, Therapeutic effect observation of electroacupuncture on analgesia after total knee arthroplasty
   White PB, 2020, J ARTHROPLASTY, V35, P3150, DOI 10.1016/j.arth.2020.06.024
   Wu TC, 2021, LANCET REG HEALTH-W, V16, DOI 10.1016/j.lanwpc.2021.100255
   Wulf G, 2013, INT REV SPORT EXER P, V6, P77, DOI 10.1080/1750984X.2012.723728
   Xiang Jilin, 2024, Zhongguo Zhen Jiu, V44, P57, DOI 10.13703/j.0255-2930.20230418-0003
   Xiao J., 2022, Guangming Chinese Med, V37, P3306
   Xiao X., 2022, Chinese J Tradit Chinese Med, V37, P3
   Xiaowei X., 2016, Chinese J Orthopaed Arthrit Surg, V9, P4, DOI [10.3969/j.issn.2095-9958.2016.06-10, DOI 10.3969/J.ISSN.2095-9958.2016.06-10]
   Xu YL., 2023, Chinese Journal of Orthopaedic Surgery, V31, P2104
   YaDeau JT, 2015, BRIT J ANAESTH, V115, P285, DOI 10.1093/bja/aev217
   Yan L., 2021, Chinese J Tissue Eng Res, V25, P957
   Yan T., 2011, Rehabilitation treatment guide, P468
   Yanchun S., 2017, Chinese Med Guide, V15, P124, DOI [10.15912/j.cnki.gocm.2017.28.099, DOI 10.15912/J.CNKI.GOCM.2017.28.099]
   Yang F., 2017, Clinical efficacy observation of auricular point application in postoperative analgesia after total knee arthroplasty
   Yebin H., 2020, Mod Preven Med, V47, P5
   Yi Z., 2019, Liaoning J Tradit Chinese Med, V46, P1045, DOI [10.13192/j.issn.1000-1719.2019.05.049, DOI 10.13192/J.ISSN.1000-1719.2019.05.049]
   Yong Y., 2017, World Latest Med Inform Digest, V17, P3
   Yonghui Z., 2018, Chinese J Acupunct Moxibust, V38, P251, DOI [10.13703/j.0255-2930.2018.03.006, DOI 10.13703/J.0255-2930.2018.03.006]
   Young Adam, 2012, Anesthesiol Clin, V30, P91, DOI 10.1016/j.anclin.2011.12.002
   Yujie G., 2022, Chinese J Tradit Chinese Med, V37, P5730
   Yuliu C., 2021, Modern Chinese Med Clin, V28, P14
   Zeng X., 2022, Massage Rehabil Med, V13, P17, DOI [10.19787/j.issn.1008-1879.2022.21.005, DOI 10.19787/J.ISSN.1008-1879.2022.21.005]
   Zequan L., 2023, J Acupunct Moxibust, V39, P29, DOI [10.19917/j.cnki.1005-0779.023173, DOI 10.19917/J.CNKI.1005-0779.023173]
   [张超 Zhang Chao], 2014, [中国循证医学杂志, Chinese Journal of Evidence-Based Medicine], V14, P884
   Zhang QX, 2023, MOL PAIN, V19, DOI 10.1177/17448069231202882
   Zhang W, 2019, CLIN EXP RHEUMATOL, V37, P118
   Zhang XH, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.657507
   Zhang Z, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.817716
   Zhao SS, 2019, BEST PRACT RES CL RH, V33, DOI 10.1016/j.berh.2019.06.005
   Zhihua Y., 2015, Clin Res Tradit Chinese Med, V34, P134, DOI [10.3969/j.issn.1674-7860.2015.34.071, DOI 10.3969/J.ISSN.1674-7860.2015.34.071]
   Zhongqing W., 2017, J Shandong Univ Tradit Chinese Med, V41, P244, DOI [10.16294/j.cnki.1007-659x.2017.03.015, DOI 10.16294/J.CNKI.1007-659X.2017.03.015]
   Zhou YF, 2018, PURINERG SIGNAL, V14, P359, DOI 10.1007/s11302-018-9617-4
   Zongwen L., 2021, Rheumatol Arthritis, V10, P13
   Zou K, 2016, ANN RHEUM DIS, V75, P1964, DOI 10.1136/annrheumdis-2015-208387
   [邹旭丽 Zou Xuli], 2018, [中华麻醉学杂志, Chinese Journal of Anesthesiology], V38, P1086, DOI 10.3760/cma.j.issn.0254-1416.2018.09.016
NR 147
TC 8
Z9 9
U1 12
U2 24
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD MAR 18
PY 2024
VL 15
AR 1361037
DI 10.3389/fneur.2024.1361037
PG 22
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA MP1P4
UT WOS:001194737700001
PM 38562427
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zeng, YC
   Luo, TZ
   Finnegan-John, J
   Cheng, ASK
AF Zeng, Yingchun
   Luo, Taizhen
   Finnegan-John, Jennifer
   Cheng, Andy S. K.
TI Meta-Analysis of Randomized Controlled Trials of Acupuncture for
   Cancer-Related Fatigue
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; cancer-related fatigue; quality of life; randomized
   controlled trials (RCTs); meta-analysis
ID LOW-BACK-PAIN; BREAST-CANCER; MANAGEMENT; COMPLEMENTARY; PREVALENCE
AB Background. Fatigue is a distressing and pervasive problem for people with cancer. In recent years, acupuncture has gained increasing attention among researchers as an alternative management strategy for cancer-related fatigue (CRF). This review aimed to evaluate the effectiveness of acupuncture for CRF. Methods. Five databases (Medline, CINAHL, Scopus, the Cochrane Library, and CAJ Full-text Database) were searched up to May 2013. Randomized controlled trials (RCTs) of acupuncture for the treatment of CRF were considered for inclusion. Results. Seven RCTs were included for meta-analysis, involving a total of 689 subjects. Three studies compared acupuncture with sham acupuncture for CRF with follow-up at 10 weeks; the standardized mean difference (SMD) for general CRF change values was -0.82 (95% confidence interval [CI] = -1.90 to 0.26). When acupuncture plus education intervention was compared with usual care, there was a statistically significant difference for the change score of general CRF (SMD = -2.12; 95% CI = -3.21 to -1.03). The SMD for general CRF change scores between acupuncture with no treatment or wait-list control was -1.46 (95% CI = -3.56 to 0.63). Finally, the SMD for general CRF change scores between acupuncture with acupressure or self-acupuncture was -1.12 (95% CI = -3.03 to 0.78). Three trials reported data for general quality of life and functioning status, reporting enough data for statistical pooling but showing no statistically significant difference (Z score = 1.15, P = .25, SMD = 0.99, 95% CI = -0.70 to 2.68 and Z score = 1.13, P = .26, SMD = 1.38, 95% CI = -1.02 to 3.79, respectively). The I-2 statistics of all statistically pooled data were higher than 50%, indicating heterogeneity between the trials. Conclusions. There were 4 sets of comparison for the effectiveness of acupuncture for CRF; statistical pooling of the reduction in CRF from baseline to follow-up showed in favor of acupuncture. However, 3 sets of comparison for the pooled estimates of effect sizes had no statistical significance. Although one set of comparison (acupuncture plus education interventions vs usual care) had statistically significant differences, it is unclear whether this pooled positive outcome is attributable to the effects of acupuncture or to the education intervention. In addition, the duration of follow-up in these included trials was up to 10 weeks, and some RCTs had methodological flaws. Further rigorously designed RCTs adhering to acceptable standards of trial methodology are required to determine the effectiveness of acupuncture and its long-term effects on CRF.
C1 [Zeng, Yingchun; Luo, Taizhen] Guangzhou Med Univ, Affiliated Hosp 3, Guangzhou 510150, Guangdong, Peoples R China.
   [Finnegan-John, Jennifer] Kings Coll London, London WC2R 2LS, England.
   [Cheng, Andy S. K.] Hong Kong Polytech Univ, Hong Kong, Hong Kong, Peoples R China.
C3 Guangzhou Medical University; University of London; King's College
   London; Hong Kong Polytechnic University
RP Zeng, YC (corresponding author), Guangzhou Med Univ, Affiliated Hosp 3, Dept Obstet, 63 DouBao Rd, Guangzhou 510150, Guangdong, Peoples R China.
EM chloezengyc@hotmail.co.uk
RI Zeng, Yingchun/AEO-1797-2022; Cheng, Andy SK/AAW-1120-2020
OI Zeng, Yingchun/0000-0001-9250-4086; Cheng, Andy SK/0000-0001-7503-5273
CR [Anonymous], REV MAN REVMAN
   Azad A, 2013, J CLIN ONCOL, V31, P2057, DOI 10.1200/JCO.2012.47.8750
   Balk Judith, 2009, J Soc Integr Oncol, V7, P4
   Berger AM, 2009, ONCOL NURS FORUM, V36, P401, DOI 10.1188/09.ONF.E165-E177
   Bishop FL, 2008, J ACUPUNCT MERIDIAN, V1, P1, DOI 10.1016/S2005-2901(09)60001-7
   Borneman T, 2013, J HOSP PALLIAT NURS, V15, P77, DOI 10.1097/NJH.0b013e318286dc19
   Cherkin DC, 2009, TRIALS, V10, DOI 10.1186/1745-6215-10-96
   Cheville AL, 2013, SUPPORT CARE CANCER, V21, P229, DOI 10.1007/s00520-012-1515-7
   Deng G, 2013, SUPPORT CARE CANCER, V21, P1735, DOI 10.1007/s00520-013-1720-z
   Escalante CP, 2009, J GEN INTERN MED, V24, P412, DOI 10.1007/s11606-009-1056-z
   Finnegan-John J, 2013, INTEGR CANCER THER, V12, P276, DOI 10.1177/1534735413485816
   Groenvold M, 2007, BREAST CANCER RES TR, V105, P209, DOI 10.1007/s10549-006-9447-x
   Higgins J., 2011, COCHRANE COLLABORATI
   Johnston MF, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-49
   Kamangar F, 2006, J CLIN ONCOL, V24, P2137, DOI 10.1200/JCO.2005.05.2308
   Kirshbaum Marilyn, 2010, Br J Community Nurs, V15, P214
   Molassiotis A, 2013, ANN ONCOL, V24, P1645, DOI 10.1093/annonc/mdt034
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P228, DOI 10.1016/j.ctim.2006.09.009
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Posadzki P, 2013, SUPPORT CARE CANCER, V21, P2067, DOI 10.1007/s00520-013-1765-z
   Rosman S, 2009, EUR J CANCER CARE, V18, P28, DOI 10.1111/j.1365-2354.2007.00863.x
   Scott JA, 2011, ONCOL NURS FORUM, V38, P368, DOI 10.1188/11.ONF.E191-E203
   Servaes P, 2002, EUR J CANCER, V38, P27, DOI 10.1016/S0959-8049(01)00332-X
   Smith C, 2013, ACUPUNCT MED, V31, P9, DOI 10.1136/acupmed-2012-010228
   Sood A, 2007, INTEGR CANCER THER, V6, P8, DOI 10.1177/1534735406298143
   Vickers AJ, 2004, J CLIN ONCOL, V22, P1731, DOI 10.1200/JCO.2004.04.102
   White Adrian, 2004, Acupunct Med, V22, P122
   Xu M, 2013, AM J CHINESE MED, V41, P1, DOI 10.1142/S0192415X13500018
   Zhang JH, 2010, B WORLD HEALTH ORGAN, V88, P915, DOI 10.2471/BLT.10.076737
NR 29
TC 47
Z9 59
U1 1
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD MAY
PY 2014
VL 13
IS 3
BP 193
EP 200
DI 10.1177/1534735413510024
PG 8
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA AH6UE
UT WOS:000336265900006
PM 24282102
OA gold
DA 2026-01-16
ER

PT J
AU Huh, JE
   Baek, YH
   Lee, MH
   Choi, DY
   Park, DS
   Lee, JD
AF Huh, Jeong-Eun
   Baek, Yong-Hyeon
   Lee, Min-Ho
   Choi, Do-Young
   Park, Dong-Suk
   Lee, Jae-Dong
TI Bee venom inhibits tumor angiogenesis and metastasis by inhibiting
   tyrosine phosphorylation of VEGFR-2 in LLC-tumor-bearing mice
SO CANCER LETTERS
LA English
DT Article
DE Bee venom; Angiogenesis; Metastasis; VEGF; VEGFR-2
ID RECOMBINANT HUMAN ENDOSTATIN; COLLAGEN-INDUCED ARTHRITIS; CELL
   LUNG-CANCER; GROWTH-FACTOR; IN-VIVO; ACUPUNCTURE APIPUNCTURE;
   ANTIANGIOGENIC THERAPY; EXPRESSION; APOPTOSIS; PAIN
AB Bee venom (BV) treatment is the therapeutic application of honeybee venom (HBV) for treating various diseases in Oriental medicine. In the present work, the authors investigated the functional specificity of BV as an angiogenesis inhibitor using in vitro models and in vivo mouse angiogenesis and lung metastasis models. BV significantly inhibited the viability of Lewis lung carcinoma (LLC) cells but did not affect peripheral blood mononuclear lymphocytes (PBML) cells. BV also inhibited vascular endothelial growth factor (VEGF)-induced proliferation, migration and capillary-like tube formation of human umbilical vein endothelial cells (HUVECs). Western blotting analysis showed that BV inhibited Ala and MAPK phosphorylation in LLC cells and HUVECs and down regulated expression of VEGF and VEGFR-2 of LLC cells and HUVECs. Also, BV effectively disrupted VEGF-induced neovascularization in Matrigel plugs in our in vivo angiogenesis assay. When given subcutaneously, BV also significantly suppressed tumor angiogenesis through inhibition of VEGF and VEGFR-2 in LLC model. Mice bearing subcutaneous LLC tumors were treated with 1 mu g/ml or 10 mu g/ml of BV. They showed reductions ranging between 49% and 62% in primary tumor volume and reduction of spontaneous pulmonary metastasis occurrences. Furthermore, BV treatment in the spontaneous lung metastases model after primary tumor excision prolonged their median survival time from 27 to 58 days. These results suggest that the tumor-specific anti-angiogenic activity of BV takes effect during different stages of tumor progression by blocking the tyrosine phosphorylation of VEGFR-2, and validate the application of BV in lung cancer treatment. (C) 2009 Published by Elsevier Ireland Ltd.
C1 [Lee, Min-Ho; Choi, Do-Young; Lee, Jae-Dong] Kyung Hee Univ, Dept Acupuncture & Moxibust, EW Neo Med Ctr, Seoul 134727, South Korea.
   [Baek, Yong-Hyeon; Park, Dong-Suk] Kyung Hee Univ, Dept Acupuncture & Moxibust, Coll Oriental Med, Seoul 130701, South Korea.
   [Huh, Jeong-Eun] Kyung Hee Univ, Oriental Med Res Ctr Bone & Joint Dis, Seoul 134727, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University; Korea
   Institute of Oriental Medicine (KIOM)
RP Lee, JD (corresponding author), Kyung Hee Univ, Dept Acupuncture & Moxibust, EW Neo Med Ctr, 149 Sangil Dong, Seoul 134727, South Korea.
EM ljdacu@khu.ac.kr
CR ANGIOLILLO AL, 1995, J EXP MED, V182, P155, DOI 10.1084/jem.182.1.155
   Baek YH, 2006, BRAIN RES, V1073, P305, DOI 10.1016/j.brainres.2005.12.086
   Cai KX, 2008, CLIN CANCER RES, V14, P939, DOI 10.1158/1078-0432.CCR-07-1930
   Folkman J, 2002, SEMIN ONCOL, V29, P15, DOI 10.1053/sonc.2002.37263
   FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182
   FOLKMAN J, 1992, J BIOL CHEM, V267, P10931
   Giaccone G, 2007, CLIN CANCER RES, V13, P1961, DOI 10.1158/1078-0432.CCR-06-2186
   Gorski DH, 1999, CANCER RES, V59, P3374
   Gutierrez M, 2008, CURR OPIN ONCOL, V20, P176, DOI 10.1097/CCO.0b013e3282f4e55e
   HIDER RC, 1988, ENDEAVOUR, V12, P60, DOI 10.1016/0160-9327(88)90082-8
   Hu HY, 2006, J PHARM PHARMACOL, V58, P83, DOI 10.1211/jpp.58.1.0010
   Jang MH, 2003, J PHARMACOL SCI, V91, P95, DOI 10.1254/jphs.91.95
   Jung MH, 2009, CARCINOGENESIS, V30, P655, DOI 10.1093/carcin/bgp039
   Kim HW, 2005, PHARMACOL RES, V51, P183, DOI 10.1016/j.phrs.2004.07.011
   Kim Hyun-Woo, 2004, J Vet Sci, V5, P309
   Kwon YB, 2001, NEUROSCI LETT, V308, P133, DOI 10.1016/S0304-3940(01)01989-9
   Lao YH, 2001, INT J BIOCHEM CELL B, V33, P357, DOI 10.1016/S1357-2725(01)00023-1
   Lariviere WR, 1996, PAIN, V66, P271, DOI 10.1016/0304-3959(96)03075-8
   Lee JD, 2004, AM J CHINESE MED, V32, P361, DOI 10.1142/S0192415X04002016
   Li TS, 2001, EUR J CANCER, V37, P2283, DOI 10.1016/S0959-8049(01)00281-7
   Ling Y, 2007, BIOCHEM BIOPH RES CO, V361, P79, DOI 10.1016/j.bbrc.2007.06.155
   Liu X, 2002, J PHARM PHARMACOL, V54, P1083, DOI 10.1211/002235702320266235
   Maniwa Y, 1998, CHEST, V114, P1668, DOI 10.1378/chest.114.6.1668
   Moon DO, 2007, INT IMMUNOPHARMACOL, V7, P1092, DOI 10.1016/j.intimp.2007.04.005
   Moon DO, 2006, INT IMMUNOPHARMACOL, V6, P1796, DOI 10.1016/j.intimp.2006.07.027
   MOSCATELLI D, 1986, J CELL PHYSIOL, V129, P273, DOI 10.1002/jcp.1041290220
   PASSANITI A, 1999, LAB INVEST, V267, P519
   Putz T, 2006, CANCER IMMUNOL IMMUN, V55, P1374, DOI 10.1007/s00262-006-0143-9
   Rodriguez SK, 2006, INT J CANCER, V118, P1635, DOI 10.1002/ijc.21545
   Scappaticci FA, 2002, J CLIN ONCOL, V20, P3906, DOI 10.1200/JCO.2002.01.033
   Son DJ, 2007, PHARMACOL THERAPEUT, V115, P246, DOI 10.1016/j.pharmthera.2007.04.004
   Suh SJ, 2006, TOXICOL IN VITRO, V20, P1465, DOI 10.1016/j.tiv.2006.06.016
   Sun JF, 2009, AM J PHYSIOL-HEART C, V296, pH1344, DOI 10.1152/ajpheart.01246.2008
   TAZAWA R, 1994, BIOCHEM BIOPH RES CO, V203, P190, DOI 10.1006/bbrc.1994.2167
   Thomas JP, 2003, J CLIN ONCOL, V21, P223, DOI 10.1200/JCO.2003.12.120
   VICK JA, 1972, TOXICON, V10, P377, DOI 10.1016/0041-0101(72)90061-X
   Watanabe K, 2004, J CLIN INVEST, V114, P898, DOI 10.1172/JC1200421152
   Wheatley-Price P, 2008, J THORAC ONCOL, V3, P1173, DOI 10.1097/JTO.0b013e318187220f
   Williams CS, 1996, AM J PHYSIOL-GASTR L, V270, pG393
   Xu R, 2003, HEPATOLOGY, V37, P1451, DOI 10.1053/jhep.2003.50244
NR 40
TC 63
Z9 70
U1 1
U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3835
EI 1872-7980
J9 CANCER LETT
JI Cancer Lett.
PD JUN 1
PY 2010
VL 292
IS 1
BP 98
EP 110
DI 10.1016/j.canlet.2009.11.013
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 597GN
UT WOS:000277744800013
PM 20188461
DA 2026-01-16
ER

PT J
AU Qu, JY
   Peng, YC
   Shen, XF
   Xiong, J
   Wang, H
   Xiao, X
   Wang, YL
AF Qu, Jinyu
   Peng, Yingchun
   Shen, Xuefang
   Xiong, Jin
   Wang, Huan
   Xiao, Xiang
   Wang, Yili
TI Electroacupuncture of Guanyuan (CV4) Acupoint Improved Pelvic
   Inflammatory Disease Pain by Inhibiting Neuroinflammation and
   Sympathetic Activity
SO IMMUNITY INFLAMMATION AND DISEASE
LA English
DT Article
DE electroacupuncture; Guanyuan acupoint; neuroinflammation; pelvic
   inflammatory disease; sympathetic activity
ID ACUPUNCTURE; SENSITIZATION; MECHANISMS
AB Objective To investigate the underlying mechanisms through which electroacupuncture (EA) at the Guanyuan (CV4) acupoint inhibits sympathetic activity and neurogenic inflammatory responses to relieve pain in rats with pelvic inflammatory disease (PID). Methods Escherichia coli and Staphylococcus aureus were used to establish a PID rat model. EA was evaluated at frequencies of 2, 100, and 2/100 Hz, and 2/100 Hz was selected for subsequent investigation. The rats were randomly divided into the control, model, EA-guanyuan (2/100 Hz), and EA-nonsensitized groups (n = 6). Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were assessed using von Frey filaments. Hematoxylin and eosin staining was performed to evaluate the histopathology. The tyrosine hydroxylase (TH) expression was analyzed using immunofluorescence (IF) staining. The levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), transforming growth factor-beta 1 (TGF-beta 1), intercellular cell adhesion molecule-1 (ICAM-1), 5-hydroxytryptamine receptor 3 (5-HT3R), substance P (SP), hyaluronic acid (HA), and bradykinin (BK) were measured using an enzyme-linked immunosorbent assay (ELISA). Western blot analysis was performed to measure the expression of 5-HT3R, calcitonin gene-related peptide (CGRP), HA, Kininogen 1 (KNG1), prostaglandin I2 (PGI2), and trefoil factor 2 (TFF2). Transmission electron microscopy (TEM) was used to observe synaptic connections. Results EA at CV4 reduced the behavioral pain score (p < 0.05), increased MWT and TWL, and alleviated uterine tissue pathological damage in rats. EA at CV4 reduced the levels of 5-HT3R, CGRP, BK, HA, KNG1, PGI2SP, TGF-beta 1, ICAM-1, and TNF-alpha, and increased IL-2 levels (p < 0.05). Furthermore, EA at CV4 inhibited sympathetic activity by decreasing TH expression (p < 0.05). Additionally, EA at CV4 restored the synaptic connections between the pelvic nerves of the dorsal commissural neuron (DCN). Conclusion EA at CV4 alleviated the pathological damage and pain sensitization of uterine tissue in rats with PID by inhibiting sympathetic activity and neurogenic inflammatory response.
C1 [Qu, Jinyu; Peng, Yingchun; Shen, Xuefang; Xiong, Jin] Chengdu Med Coll, Affiliated Hosp 1, Dept Neurol, Chengdu, Peoples R China.
   [Wang, Huan; Wang, Yili] Chengdu Med Coll, Affiliated Hosp 1, Dept Rehabil Med, Chengdu, Peoples R China.
   [Xiao, Xiang] Chengdu Med Coll, Affiliated Hosp 1, Dept Nephrol, Chengdu, Peoples R China.
C3 Chengdu Medical College; Chengdu Medical College; Chengdu Medical
   College
RP Wang, YL (corresponding author), Chengdu Med Coll, Affiliated Hosp 1, Dept Rehabil Med, Chengdu, Peoples R China.; Xiao, X (corresponding author), Chengdu Med Coll, Affiliated Hosp 1, Dept Nephrol, Chengdu, Peoples R China.
EM 301397@cmc.edu.cn; wangyili@cmc.edu.cn
FU This study was supported by medical research project plan of Sichuan
   Province (S21099) and medical research project plan of Chengdu
   (2023382).
FX This study was supported by medical research project plan of Sichuan
   Province (S21099) and medical research project plan of Chengdu
   (2023382).
CR [Anonymous], 1991, Laboratory Animals and Animal Experi (Chinese)
   Brunham RC, 2015, NEW ENGL J MED, V372, P2039, DOI 10.1056/NEJMra1411426
   Chen M, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.882214
   Cui X, 2023, J PAIN RES, V16, P2997, DOI 10.2147/JPR.S424841
   Cui X, 2022, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.822436
   D'Costa VM, 2011, NATURE, V477, P457, DOI 10.1038/nature10388
   Doménech-García V, 2016, PAIN, V157, P1164, DOI 10.1097/j.pain.0000000000000497
   Engel M, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00076
   Favoni V, 2019, J HEADACHE PAIN, V20, DOI 10.1186/s10194-019-0979-y
   Gao XY, 2021, PAIN, V162, P1068, DOI 10.1097/j.pain.0000000000002096
   Gomez R, 2011, PAIN, V152, P1548, DOI 10.1016/j.pain.2011.02.044
   Gustafsson JK, 2011, AM J PHYSIOL-GASTR L, V300, pG1080, DOI 10.1152/ajpgi.00349.2010
   Hillier SL, 2021, J INFECT DIS, V224, pS23, DOI 10.1093/infdis/jiab116
   Ji BY, 2017, BIOMED PHARMACOTHER, V94, P1057, DOI 10.1016/j.biopha.2017.08.042
   Ji H., 2022, Guizhou Med J (Chinese), V46, P296
   Kanda H, 2017, ENEURO, V4, DOI 10.1523/ENEURO.0064-17.2017
   KEEGAN JJ, 1948, ANAT RECORD, V102, P409, DOI 10.1002/ar.1091020403
   Kim DH, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-14359-z
   Li X., 2013, Chin J Exp Tradit Med Form (Chinese), V19, P225
   Liang Zhuo, 2021, Zhongguo Zhen Jiu, V41, P395, DOI 10.13703/j.0255-2930.20200329-k0003
   Lin YT, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-126
   Lin YW, 2022, BRAIN BEHAV IMMUN, V100, P8, DOI 10.1016/j.bbi.2021.11.008
   Liu J, 2013, PURINERG SIGNAL, V9, P463, DOI 10.1007/s11302-013-9367-2
   Liu LZ, 2016, COMPLEMENT THER MED, V26, P28, DOI 10.1016/j.ctim.2016.02.013
   Liu Z. F., 2018, Henan Tradit Chin Med (Chinese), V38, P1747
   Ozel S, 2011, ACUPUNCT MED, V29, P317, DOI 10.1136/acupmed-2011-010080
   Petrey AC, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00101
   Qin C, 2010, AM J PHYSIOL-GASTR L, V298, pG934, DOI 10.1152/ajpgi.00312.2009
   Ravel J, 2021, AM J OBSTET GYNECOL, V224, P251, DOI 10.1016/j.ajog.2020.10.019
   Savaris RF, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010285.pub3
   Schlievert PM, 2022, MICROBIOL SPECTR, V10, DOI 10.1128/spectrum.00106-22
   Soper DE, 2010, OBSTET GYNECOL, V116, P419, DOI 10.1097/AOG.0b013e3181e92c54
   [王飞 Wang Fei], 2014, [中国疼痛医学杂志, Chinese Journal of Pain Medicine], V20, P304
   Wang YH, 2023, NEURAL PLAST, V2023, DOI 10.1155/2023/8510213
   Wang YL, 2019, NEUROPEPTIDES, V77, DOI 10.1016/j.npep.2019.101957
   Wu Dan, 2018, Zhen Ci Yan Jiu, V43, P57, DOI 10.13702/j.1000-0607.160661
   [吴强 Wu Qiang], 2019, [中医杂志, Journal of Traditional Chinese Medicine], V60, P2001
   Wu Song, 2018, Zhongguo Zhen Jiu, V38, P1267, DOI 10.13703/j.0255-2930.2018.12.004
   Xu C, 2022, J TRADIT CHIN MED, V42, P965, DOI 10.19852/j.cnki.jtcm.20220928.003
   Yamakita S, 2023, MOL PAIN, V19, DOI 10.1177/17448069231181973
   Yang Y, 2024, CHIN J INTEGR MED, V30, P152, DOI 10.1007/s11655-023-3565-8
   Yi YJ, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041974
   Zeilhofer HU, 2012, ANNU REV PHARMACOL, V52, P111, DOI 10.1146/annurev-pharmtox-010611-134636
   Zhang RX, 2014, ANESTHESIOLOGY, V120, P482, DOI 10.1097/ALN.0000000000000101
   Zhang Y, 2018, CHIN MED-UK, V13, DOI 10.1186/s13020-018-0217-6
   Zhang ZY, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.812587
   Zheng XJ, 2018, J IMMUNOL, V200, P2941, DOI 10.4049/jimmunol.1701658
   Zieglgänsberger W, 2019, CELL TISSUE RES, V375, P227, DOI 10.1007/s00441-018-2922-y
   Zou W, 2021, J ETHNOPHARMACOL, V266, DOI 10.1016/j.jep.2020.113405
NR 49
TC 0
Z9 0
U1 5
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2050-4527
J9 IMMUN INFLAMM DIS
JI IMMUN. INFLAMM. DIS.
PD NOV 5
PY 2025
VL 13
IS 11
AR e70299
DI 10.1002/iid3.70299
PG 12
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 9ME1X
UT WOS:001609664800001
PM 41194515
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, HJ
   Doorenbos, AZ
   Xia, YL
   Sun, J
   Choi, H
   Harris, RE
   Gao, S
   Sullivan, K
   Schlaeger, JM
AF Li, Hongjin
   Doorenbos, Ardith Z.
   Xia, Yinglin
   Sun, Jun
   Choi, Hannah
   Harris, Richard E.
   Gao, Shuang
   Sullivan, Katy
   Schlaeger, Judith M.
TI Using Serum Metabolomic Signatures to Investigate Effects of Acupuncture
   on Pain-Fatigue-Sleep Disturbance in Breast Cancer Survivors
SO METABOLITES
LA English
DT Article
DE acupuncture; breast cancer; fatigue; metabolomics; pain;
   psychoneurological symptom cluster; sleep disturbance
ID SYMPTOM CLUSTER; WOMEN; FEASIBILITY
AB Background/Objectives: Acupuncture is an efficacious integrative therapy for treating pain, fatigue, and sleep disturbance (the psychoneurological symptom cluster) in breast cancer survivors. However, the mechanisms underlying its effects remain unclear, and related metabolomics studies are limited. This study aimed to examine serum metabolite changes after acupuncture and their relationships to symptom improvement. Methods: Forty-two breast cancer survivors experiencing pain, fatigue, and sleep disturbance participated in a single-arm acupuncture trial. They received a 10-session acupuncture intervention over 5 weeks. Fasting blood samples and symptom surveys were collected before and after the acupuncture intervention, and untargeted metabolomics profiling was conducted on serum samples. Mixed-effects models adjusting for covariates (age, race, body mass index, and antidepressant use) were applied for analysis. Results: After acupuncture, there was a significant reduction in the psychoneurological symptom cluster (mean reduction = -6.2, p < 0.001).Bonferroni correction was applied to 40 independent metabolite clusters (alpha = 0.00125); cysteine-glutathione disulfide (p = 0.0006) significantly increased, and retinal (p = 0.0002) and cis-urocanate (p = 0.0005) were significantly decreased. Dimethyl sulfone (p = 0.00139) showed a trend towards reduction after acupuncture and its change (p = 0.04, beta =1.97) was positively associated with reduction in the psychoneurological symptom cluster. Also, increased lauroylcarnitine (p = 0.0009) and decreased cytosine (p = 0.0008) can modulate the therapeutic effects of acupuncture. Conclusions: Acupuncture demonstrates beneficial effects on the psychoneurological symptom cluster in breast cancer survivors. Dimethyl sulfone may be a promising mediator in the relationship between acupuncture and psychoneurological symptoms, while acylcarnitine metabolism may modulate the therapeutic effect of acupuncture.
C1 [Li, Hongjin; Doorenbos, Ardith Z.; Choi, Hannah; Sullivan, Katy; Schlaeger, Judith M.] Univ Illinois, Coll Nursing, 845 S Damen Ave, Chicago, IL 60612 USA.
   [Li, Hongjin; Doorenbos, Ardith Z.; Sun, Jun] Univ Illinois, Canc Ctr, 818 South Wolcott Ave, Chicago, IL 60612 USA.
   [Xia, Yinglin; Sun, Jun; Gao, Shuang] Univ Illinois, Chicago Coll Med, 1853 W Polk St, Chicago, IL 60612 USA.
   [Harris, Richard E.] Univ Calif Irvine, Susan Samueli Integrat Hlth Inst, Sch Med, 856 Hlth Sci Rd Suite 2600, Irvine, CA 92617 USA.
   [Harris, Richard E.] Univ Calif Irvine, Sch Med, Dept Surg, 333 City Blvd West,Suite 850, Orange, CA 92868 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of California
   System; University of California Irvine; University of California
   System; University of California Irvine
RP Li, HJ (corresponding author), Univ Illinois, Coll Nursing, 845 S Damen Ave, Chicago, IL 60612 USA.; Li, HJ (corresponding author), Univ Illinois, Canc Ctr, 818 South Wolcott Ave, Chicago, IL 60612 USA.
EM hongjin@uic.edu; ardith@uic.edu; yxia@uic.edu; junsun7@uic.edu;
   hchoi213@uic.edu; richareh@uci.edu; sgao20@uic.edu; ksulli33@uic.edu;
   jschlaeg@uic.edu
RI ; Sun, Jun/S-7440-2019; schlaeger, Judith/N-4482-2017
OI Xia, Yinglin/0000-0001-6857-7437; Li, Hongjin/0000-0002-5466-1192; Sun,
   Jun/0000-0001-7465-3133; schlaeger, Judith/0000-0002-3754-6176; Choi,
   Hannah/0000-0002-1278-7969
FU National Cancer Institute; National Center for Complementary and
   Integrative Health [K24AT011995];  [R21 CA277153]
FX This work was supported by the National Cancer Institute (R21 CA277153)
   and National Center for Complementary and Integrative Health
   (K24AT011995).
CR Acuna I, 2022, BIOFACTORS, V48, P315, DOI 10.1002/biof.1766
   Al-Bashaireh AM, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.19953
   Amtmann D, 2010, PAIN, V150, P173, DOI 10.1016/j.pain.2010.04.025
   Bahrami Taghanaki H.R., 2021, J. Nutr. Fasting Health, V9, P196, DOI DOI 10.22038/JNFH.2021.54314.1310
   Beger RD, 2016, METABOLOMICS, V12, DOI 10.1007/s11306-016-1094-6
   Bjerkeset E, 2020, BREAST CANCER RES TR, V180, P63, DOI 10.1007/s10549-020-05522-8
   Butawan M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030290
   Cella D, 2010, J CLIN EPIDEMIOL, V63, P1179, DOI 10.1016/j.jclinepi.2010.04.011
   Cessna JM, 2016, J PSYCHOSOM RES, V81, P9, DOI 10.1016/j.jpsychores.2015.12.002
   Dambrova M, 2022, PHARMACOL REV, V74, P506, DOI 10.1124/pharmrev.121.000408
   DeHaven CD, 2012, METABOLOMICS, P167
   Denieffe S, 2014, J CLIN NURS, V23, P2491, DOI 10.1111/jocn.12430
   DiNicolantonio JJ, 2018, OPEN HEART, V5, DOI 10.1136/openhrt-2017-000676
   Goralski T, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020717
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Iwase S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134022
   Jinushi R, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04226-z
   JOCELYN PC, 1967, EUR J BIOCHEM, V2, P327, DOI 10.1111/j.1432-1033.1967.tb00142.x
   Kaneko K, 2011, J INVEST DERMATOL, V131, P1262, DOI 10.1038/jid.2011.37
   Kwon KK, 2024, SUPPORT CARE CANCER, V32, DOI 10.1007/s00520-024-08529-9
   Langford DJ, 2016, SUPPORT CARE CANCER, V24, P605, DOI 10.1007/s00520-015-2819-1
   Li HJ, 2024, CONTEMP CLIN TRIALS, V136, DOI 10.1016/j.cct.2023.107387
   Li HJ, 2023, BIOL RES NURS, V25, P326, DOI 10.1177/10998004221136567
   Li HJ, 2021, J ALTERN COMPLEM MED, V27, P1084, DOI 10.1089/acm.2021.0133
   Li MY, 2023, EUR J ONCOL NURS, V66, DOI 10.1016/j.ejon.2023.102380
   Li W, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000022752
   Lv Z, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.921119
   MacPherson H, 2002, J ALTERN COMPLEM MED, V8, P85, DOI 10.1089/107555302753507212
   MacPherson H, 2001, BMJ-BRIT MED J, V323, P486, DOI 10.1136/bmj.323.7311.486
   McFarlin Brian K, 2024, Methods, V230, P68, DOI [10.1016/j.ymeth.2024.07.013, 10.1016/j.ymeth.2024.07.013]
   Nicholson JK, 2002, NAT REV DRUG DISCOV, V1, P153, DOI 10.1038/nrd728
   Otte JL, 2011, CLIN NURSE SPEC, V25, P228, DOI 10.1097/NUR.0b013e318229950b
   Palczewski K, 2020, P NATL ACAD SCI USA, V117, P19629, DOI 10.1073/pnas.2008211117
   Peterson Ryan Andrew, 2023, CRAN
   Quach CW, 2016, QUAL LIFE RES, V25, P2811, DOI 10.1007/s11136-016-1325-3
   Sarzi-Puttini P, 2021, PHARMACOL RES, V173, DOI 10.1016/j.phrs.2021.105874
   Smith C, 2013, ACUPUNCT MED, V31, P9, DOI 10.1136/acupmed-2012-010228
   Storesund SK, 2022, INT J CARDIOL CARDIO, V14, DOI 10.1016/j.ijcrp.2022.200134
   Thompson FE, 2017, J NUTR, V147, P1226, DOI 10.3945/jn.116.246058
   Wu QF, 2016, SCI REP-UK, V6, DOI 10.1038/srep18852
   Xia QC, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000034768
   Xing Bei-Bei, 2018, Zhen Ci Yan Jiu, V43, P433, DOI 10.13702/j.1000-0607.180066
   Yang MX, 2016, SCI REP-UK, V6, DOI 10.1038/srep25871
   Yu L, 2012, BEHAV SLEEP MED, V10, P6, DOI 10.1080/15402002.2012.636266
   Zhang AH, 2016, SCI REP-UK, V6, DOI 10.1038/srep19942
   Zhang IW, 2024, JHEP REP, V6, DOI 10.1016/j.jhepr.2024.101187
   Zhao Y, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0271098
   Zhou Q, 2015, CANCER INFORM, V14, P139, DOI 10.4137/CIN.S17276
   Zick SM, 2018, JNCI CANCER SPECT, V2, DOI 10.1093/jncics/pky064
   Zick SM, 2014, BRAIN IMAGING BEHAV, V8, P506, DOI 10.1007/s11682-013-9270-z
NR 50
TC 1
Z9 1
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2024
VL 14
IS 12
AR 698
DI 10.3390/metabo14120698
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q6G6J
UT WOS:001385642400001
PM 39728478
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU de Matos, NMP
   Pach, D
   Xing, JJ
   Barth, J
   Beyer, LE
   Shi, XM
   Kern, A
   Lukic, N
   Ettlin, DA
   Brügger, M
   Witt, CM
AF de Matos, Nuno M. P.
   Pach, Daniel
   Xing, Jing Jing
   Barth, Jurgen
   Beyer, Lara Elena
   Shi, Xuemin
   Kern, Alexandra
   Lukic, Nenad
   Ettlin, Dominik A.
   Brugger, Mike
   Witt, Claudia M.
TI Evaluating the Effects of Acupuncture Using a Dental Pain Model in
   Healthy Subjects - A Randomized, Cross-Over Trial
SO JOURNAL OF PAIN
LA English
DT Article
DE Acupuncture; pain; toothache; nociception; Medicine; Chinese traditional
ID TENSION-TYPE HEADACHE; POSTOPERATIVE PAIN; PLACEBO ANALGESIA; ANXIETY;
   PREDICTORS; OPTIMISM; OSTEOARTHRITIS; ASSOCIATIONS; EXPERIENCE; OUTCOMES
AB Acupuncture is a complementary and nonpharmacological intervention that can be effective for the management of chronic pain in addition to or instead of medication. Various animal models for neuropathic pain, inflammatory pain, cancer-related pain, and visceral pain already exist in acupuncture research. We used a newly validated human pain model and examined whether acupuncture can influence experimentally induced dental pain. For this study, we compared the impact of manual acupuncture (real acupuncture), manual stimulation of a needle inserted at nonacupuncture points (sham acupuncture) and no acupuncture on experimentally induced dental pain in 35 healthy men who were randomized to different sequences of all 3 interventions in a within-subject design. BORG CR10 pain ratings and autonomic responses (electrodermal activity and heart rate variability) were investigated. An initial mixed model with repeated measures included preintervention pain ratings and the trial sequence as covariates. The results showed that acupuncture was effective in reducing pain intensity when compared to no acupuncture (beta = -.708, P = .002), corresponding to a medium Cohen's d effect size of .56. The comparison to the sham acupuncture revealed no statistically significant difference. No differences in autonomic responses between real and sham acupuncture were found during the intervention procedures.
   Perspective: This study established a dental pain model for acupuncture research and provided evidence that experimentally induced dental pain can be influenced by either real acupuncture or manual stimulation of needles at nonacupuncture points. The data do not support that acupoint specificity is a significant factor in reducing experimental pain. (C) 2020 THE AUTHORS. Published by Elsevier Inc. on behalf of the U.S Association forthe Study of Pain.
C1 [de Matos, Nuno M. P.; Pach, Daniel; Barth, Jurgen; Beyer, Lara Elena; Shi, Xuemin; Kern, Alexandra; Witt, Claudia M.] Univ Zurich, Inst Complementary & Integrat Med, Zurich, Switzerland.
   [de Matos, Nuno M. P.; Pach, Daniel; Barth, Jurgen; Beyer, Lara Elena; Shi, Xuemin; Kern, Alexandra; Witt, Claudia M.] Univ Hosp Zurich, Zurich, Switzerland.
   [de Matos, Nuno M. P.; Lukic, Nenad; Ettlin, Dominik A.; Brugger, Mike] Univ Zurich, Ctr Dent Med, Clin Craniomaxillofacial & Oral Surg, Zurich, Switzerland.
   [Brugger, Mike] Swiss Fed Inst Technol, Inst Biomed Engn, Zurich, Switzerland.
   [Brugger, Mike] Univ Zurich, Zurich, Switzerland.
   [Pach, Daniel; Witt, Claudia M.] Charite Univ Med Berlin, Berlin, Germany.
   [Pach, Daniel; Witt, Claudia M.] Humboldt Univ, Freie Univ Berlin, Berlin, Germany.
   [Pach, Daniel; Witt, Claudia M.] Berlin Inst Hlth, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.
   [Xing, Jing Jing] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China.
   [Witt, Claudia M.] Univ Maryland, Sch Med Baltimore, Ctr Integrat Med, Baltimore, MD USA.
C3 University of Zurich; University of Zurich; University Zurich Hospital;
   University of Zurich; Swiss Federal Institutes of Technology Domain; ETH
   Zurich; University of Zurich; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Humboldt
   University of Berlin; Free University of Berlin; Humboldt University of
   Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin;
   Berlin Institute of Health; Tianjin University of Traditional Chinese
   Medicine; University System of Maryland; University of Maryland
   Baltimore
RP Pach, D (corresponding author), Univ Zurich, Inst Complementary & Integrat Med, Zurich, Switzerland.; Pach, D (corresponding author), Univ Hosp Zurich, Zurich, Switzerland.
EM daniel.pach@uzh.ch
RI Witt med, Claudia M/AAX-2370-2021; Barth, Jürgen/F-9987-2011; shi,
   xuemin/LQK-7894-2024
OI Witt med, Claudia M/0000-0002-5440-7805; Pach,
   Daniel/0000-0002-2459-6596; 
CR ALABSI M, 1991, PAIN, V46, P43, DOI 10.1016/0304-3959(91)90032-S
   [Anonymous], 2011, J ACUPUNCT TUINA SCI
   Appelhans BM, 2008, BIOL PSYCHOL, V77, P174, DOI 10.1016/j.biopsycho.2007.10.004
   Barlas P, 2000, CLIN J PAIN, V16, P255, DOI 10.1097/00002508-200009000-00012
   Barth J, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-026712
   Beissner F, 2012, NEUROIMAGE, V60, P653, DOI 10.1016/j.neuroimage.2011.12.045
   [卞金玲 Bian Jinling], 2003, [中国针灸, Chinese Acupuncture and Moxibustion], V23, P287
   Birch S, 2017, J ALTERN COMPLEM MED, V23, P242, DOI 10.1089/acm.2016.0385
   Borg G., 1998, Borg's perceived exertion and pain scales: Human kinetics, DOI DOI 10.1097/00005768-199809000-00018
   Bourdillon N, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00456
   Brinkhaus B, 2006, ARCH INTERN MED, V166, P450
   Brügger M, 2012, J DENT RES, V91, P156, DOI 10.1177/0022034511431253
   Brügger M, 2011, FRONT HUM NEUROSCI, V5, DOI 10.3389/fnhum.2011.00012
   BYERS MR, 1984, INT REV NEUROBIOL, V25, P39, DOI 10.1016/S0074-7742(08)60677-7
   Cacioppo JT, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P1, DOI 10.2277/ 0521844711
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Chae Y, 2013, J PAIN, V14, P215, DOI 10.1016/j.jpain.2012.11.011
   Charron J, 2006, CLIN J PAIN, V22, P204, DOI 10.1097/01.ajp.0000161526.25374.e5
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   CORNWALL A, 1988, PAIN, V35, P105, DOI 10.1016/0304-3959(88)90282-5
   de Matos NMP, 2017, NEUROIMAGE, V162, P162, DOI 10.1016/j.neuroimage.2017.08.078
   De Pascalis V, 2002, PAIN, V96, P393, DOI 10.1016/S0304-3959(01)00485-7
   Dhond RP, 2007, J ALTERN COMPLEM MED, V13, P603, DOI 10.1089/acm.2007.7040
   Duschek S, 2007, INT J PSYCHOPHYSIOL, V65, P193, DOI 10.1016/j.ijpsycho.2007.03.012
   Ernst E, 1998, BRIT DENT J, V184, P443, DOI 10.1038/sj.bdj.4809654
   Ettlin DA, 2016, J NEUROPHYSIOL, V115, P1730, DOI 10.1152/jn.00917.2015
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
   Fujita T, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03542-x
   Goldman N, 2010, NAT NEUROSCI, V13, P883, DOI 10.1038/nn.2562
   Goodin BR, 2013, J PAIN, V14, P126, DOI 10.1016/j.jpain.2012.10.007
   Gutzeit A, 2013, EUR RADIOL, V23, P450, DOI 10.1007/s00330-012-2621-0
   Herman PM, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-001046
   Huang WJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032960
   Ip HYV, 2009, ANESTHESIOLOGY, V111, P657, DOI 10.1097/ALN.0b013e3181aae87a
   Jonas W, 2017, INTEGRATIVE APPROACH
   Kaptchuk TJ, 2002, ANN INTERN MED, V136, P374, DOI 10.7326/0003-4819-136-5-200203050-00010
   Karst M, 2000, PAIN, V88, P199, DOI 10.1016/S0304-3959(00)00315-8
   Kong J, 2005, J PAIN, V6, P55, DOI 10.1016/j.jpain.2004.10.005
   Kong J, 2007, J ALTERN COMPLEM MED, V13, P1059, DOI 10.1089/acm.2007.0524
   Langevin HM, 2018, J ALTERN COMPLEM MED, V24, P200, DOI 10.1089/acm.2017.0366
   Langevin HM, 2015, J ALTERN COMPLEM MED, V21, P113, DOI 10.1089/acm.2014.0186
   Langevin HM, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1155/2011/180805
   Langevin HM, 2006, J CELL PHYSIOL, V207, P767, DOI 10.1002/jcp.20623
   Laux L., 1981, STATE TRAIT ANXIETY
   Leung A, 2014, MOL PAIN, V10, DOI 10.1186/1744-8069-10-23
   Linde K, 2005, JAMA-J AM MED ASSOC, V293, P2118, DOI 10.1001/jama.293.17.2118
   Linde K, 2007, PAIN, V128, P264, DOI 10.1016/j.pain.2006.12.006
   Lumb BA, 2004, NEWS PHYSIOL SCI, V19, P22, DOI 10.1152/nips.01467.2003
   MacPherson H, 2001, BMJ-BRIT MED J, V323, P486, DOI 10.1136/bmj.323.7311.486
   Madsen C, 2018, MED ACUPUNCT, V30, P33, DOI 10.1089/acu.2017.1260
   Meier ML, 2015, J DENT RES, V94, P690, DOI 10.1177/0022034515572022
   Meier ML, 2014, FRONT HUM NEUROSCI, V8, DOI 10.3389/fnhum.2014.00526
   Melchart D, 2005, BMJ-BRIT MED J, V331, P376, DOI 10.1136/bmj.38512.405440.8F
   Micalos PS, 2011, J ALTERN COMPLEM MED, V17, P57, DOI 10.1089/acm.2010.0040
   More Ari O, 2013, J Caffeine Res, V3, P143, DOI 10.1089/jcr.2013.0014
   Musial F, 2012, ACUPUNCT MED, V30, P21, DOI 10.1136/acupmed-2011-010094
   Nahman-Averbuch H, 2014, EUR J PAIN, V18, P47, DOI 10.1002/j.1532-2149.2013.00349.x
   Napadow V, 2008, J ALTERN COMPLEM MED, V14, P861, DOI 10.1089/acm.2008.SAR-3
   Nierhaus T, 2016, FRONT HUM NEUROSCI, V10, DOI 10.3389/fnhum.2016.00404
   Nierhaus T, 2015, FRONT HUM NEUROSCI, V9, DOI 10.3389/fnhum.2015.00074
   Pan PH, 2006, ANESTHESIOLOGY, V104, P417, DOI 10.1097/00000542-200603000-00007
   Price DD, 1999, PAIN, V83, P147, DOI 10.1016/S0304-3959(99)00081-0
   Rhudy JL, 2000, PAIN, V84, P65, DOI 10.1016/S0304-3959(99)00183-9
   Sawynok J, 2016, NEUROSCIENCE, V338, P1, DOI 10.1016/j.neuroscience.2015.10.031
   SCHEIER MF, 1985, HEALTH PSYCHOL, V4, P219, DOI 10.1037/0278-6133.4.3.219
   SCHEIER MF, 1994, J PERS SOC PSYCHOL, V67, P1063, DOI 10.1037/0022-3514.67.6.1063
   Sedan O, 2005, PAIN, V113, P354, DOI 10.1016/j.pain.2004.11.012
   SESSLE BJ, 1987, DENT CLIN N AM, V31, P595
   Shi X, 2013, SHI XM COMPREHENSIVE
   Sommer M, 2010, CLIN J PAIN, V26, P87, DOI 10.1097/AJP.0b013e3181b43d68
   Takano T, 2012, J PAIN, V13, P1215, DOI 10.1016/j.jpain.2012.09.012
   Tang Y, 2016, NEUROSCIENTIST, V22, P563, DOI 10.1177/1073858416654453
   Theysohn N, 2014, J ALTERN COMPLEM MED, V20, P893, DOI 10.1089/acm.2014.0105
   Vaughn Felicia, 2007, AORN J, V85, P589, DOI 10.1016/S0001-2092(07)60130-6
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Wiesenfeld-Hallin Zsuzsanna, 2005, Gend Med, V2, P137, DOI 10.1016/S1550-8579(05)80042-7
   Witt C, 2005, LANCET, V366, P136, DOI 10.1016/S0140-6736(05)66871-7
   Witt CM, 2009, FORSCH KOMPLEMENTMED, V16, P91, DOI 10.1159/000209315
   Yin C, 2017, CURR OPIN ANESTHESIO, V30, P583, DOI 10.1097/ACO.0000000000000501
   Zhu SP, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/518784
   Zunhammer M, 2013, PAIN MED, V14, P843, DOI 10.1111/pme.12085
NR 82
TC 10
Z9 13
U1 1
U2 26
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
EI 1528-8447
J9 J PAIN
JI J. Pain
PD MAR-APR
PY 2020
VL 21
IS 3-4
BP 440
EP 454
DI 10.1016/j.jpain.2019.08.013
PG 15
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA MX7IM
UT WOS:000557894300017
PM 31521794
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Rostock, M
   Jaroslawski, K
   Guethlin, C
   Ludtke, R
   Schröder, S
   Bartsch, HH
AF Rostock, M.
   Jaroslawski, K.
   Guethlin, C.
   Ludtke, R.
   Schroeder, S.
   Bartsch, H. H.
TI Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A
   Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID CLINICAL-TRIALS; ACUPUNCTURE; PAIN; PREVENTION; MANAGEMENT
AB Purpose. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of cytostatic drugs. Since there are no proven therapeutic procedures against CIPN, we were interested to define the role of electroacupuncture (EA) from which preliminary data showed promising results. Methods. In a randomized trial with a group sequential adaptive design in patients with CIPN, we compared EA (LV3, SP9, GB41, GB34, LI4, LI11, SI3, and HT3; n = 14) with hydroelectric baths (HB, n = 14), vitamin B1/B6 capsules (300/300mg daily; VitB, n = 15), and placebo capsules (n = 17). The statistical power in this trial was primarily calculated for proving EA only, so results of HB and VitB are pilot data. Results. CIPN complaints improved by 0.8 +/- 1.2 (EA), 1.7+ 1.7 (HB), 1.6+ 2.0 (VitB), and 1.3+ 1.3 points (placebo) on a 10-point numeric rating scale without significant difference between treatment groups or placebo. In addition no significant differences in sensory nerve conduction studies or quality of life (EORTC QLQ-C30) were found. Conclusions. The used EA concept, HB, and VitB were not superior to placebo. Since, contrary to our results, studies with different acupuncture concepts showed a positive effect on CIPN, the effect of acupuncture on CIPN remains unclear. Further randomized, placebo controlled studies seem necessary. This trial is registered with DRKS00004448.
C1 [Rostock, M.; Jaroslawski, K.; Bartsch, H. H.] Univ Freiburg, Tumor Biol Ctr, D-79106 Freiburg, Germany.
   [Rostock, M.] Univ Zurich Hosp, Inst Complementary Med, CH-8006 Zurich, Switzerland.
   [Rostock, M.] Univ Canc Ctr Hamburg, Hubertus Wald Tumor Ctr, D-20246 Hamburg, Germany.
   [Jaroslawski, K.; Guethlin, C.] Univ Med Ctr Freiburg, D-79106 Freiburg, Germany.
   [Guethlin, C.] Goethe Univ Frankfurt, Inst Gen Practice, D-60590 Frankfurt, Germany.
   [Ludtke, R.] Carstens Fdn Essen, D-45276 Essen, Germany.
   [Schroeder, S.] Univ Med Ctr Hamburg Eppendorf, Hanse Merkur Ctr Tradit Chinese Med, D-20246 Hamburg, Germany.
C3 University of Freiburg; University of Zurich; University Zurich
   Hospital; University of Hamburg; University Medical Center
   Hamburg-Eppendorf; University of Freiburg; Goethe University Frankfurt;
   University of Hamburg; University Medical Center Hamburg-Eppendorf
RP Rostock, M (corresponding author), Univ Freiburg, Tumor Biol Ctr, Hugstetter Str 55, D-79106 Freiburg, Germany.
EM m.rostock@uke.de
RI Güthlin, Corina/AAP-2322-2020
OI Güthlin, Corina/0000-0001-8490-467X
FU Fordergesellschaft Forschung Tumorbiologie, Freiburg, Germany; Karl and
   Veronica Carstens Foundation, Essen, Germany
FX This study was supported by the Fordergesellschaft Forschung
   Tumorbiologie, Freiburg, Germany, and the Karl and Veronica Carstens
   Foundation, Essen, Germany.
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   Abuaisha BB, 1998, DIABETES RES CLIN PR, V39, P115, DOI 10.1016/S0168-8227(97)00123-X
   Ahn Andrew C, 2007, Acupunct Med, V25, P11
   Albers J, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005228.pub2
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Ang CD, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004573.pub3
   Bao T, 2011, PAIN RES TREAT, V2011, DOI 10.1155/2011/920807
   BAUER P, 1994, BIOMETRICS, V50, P1029, DOI 10.2307/2533441
   Brunelli B, 2004, J NEUROL SCI, V218, P59, DOI 10.1016/j.jns.2003.10.013
   Cavaletti G, 2013, ANN ONCOL, V24, P454, DOI 10.1093/annonc/mds329
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Dwan K, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003081
   Galantino MLA, 1999, J ALTERN COMPLEM MED, V5, P135, DOI 10.1089/acm.1999.5.135
   Grober J., 1963, KLIN LEHRBUCH PHYS T
   Hausheer FH, 2006, SEMIN ONCOL, V33, P15, DOI 10.1053/j.seminoncol.2005.12.010
   Hui Kathleen K S, 2007, BMC Complement Altern Med, V7, P33, DOI 10.1186/1472-6882-7-33
   Lee H, 2005, EUR J PAIN, V9, P437, DOI 10.1016/j.ejpain.2004.10.004
   Littner Y, 2005, ARCH PEDIAT ADOL MED, V159, P1036, DOI 10.1001/archpedi.159.11.1036
   Maurer W., 1995, BIOMETRIE CHEM PHARM, V6, P2
   Meng XZ, 2011, BRAIN RES, V1414, P58, DOI 10.1016/j.brainres.2011.08.004
   Minton O, 2007, J PAIN SYMPTOM MANAG, V33, P115, DOI 10.1016/j.jpainsymman.2006.09.011
   *NCI, 1999, CANC THER EV PROGR C
   Ocean AJ, 2004, SUPPORT CARE CANCER, V12, P619, DOI 10.1007/s00520-004-0657-7
   Pachman DR, 2011, CLIN PHARMACOL THER, V90, P377, DOI 10.1038/clpt.2011.115
   Phillips KD, 2004, J ALTERN COMPLEM MED, V10, P449, DOI 10.1089/1075553041323678
   Postma TJ, 2000, ANN ONCOL, V11, P509, DOI 10.1023/A:1008345613594
   Raffe M.R., 1985, Textbook of Small Animal Orthopaedics
   Schroder S., 2008, Journal of Acupuncture and Tuina Science, V6, P312
   Schröder S, 2007, EUR J NEUROL, V14, P276, DOI 10.1111/j.1468-1331.2006.01632.x
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   STUX G, 1999, AKUPUNKTUR LEHRBUCH
   Unnebrink K, 2001, STAT MED, V20, P3931, DOI 10.1002/sim.1149
   Visovsky Constance, 2007, Clin J Oncol Nurs, V11, P901
   Wang YF, 2005, CHINESE J ORG CHEM, V25, P8
   Weis J, 2006, RES REHABILITATION R, P162
   Wickham Rita, 2007, Clin J Oncol Nurs, V11, P361, DOI 10.1188/07.CJON.361-376
   Wolf S, 2008, EUR J CANCER, V44, P1507, DOI 10.1016/j.ejca.2008.04.018
   Wong Raimond, 2006, Acupunct Med, V24, P87
   Xu Wei-Ru, 2010, Zhongguo Zhen Jiu, V30, P457
NR 39
TC 65
Z9 73
U1 1
U2 24
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 349653
DI 10.1155/2013/349653
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 215AH
UT WOS:000324181000001
PM 24066010
OA Green Submitted, Green Published, hybrid
DA 2026-01-16
ER

PT J
AU Cheon, S
   Zhang, X
   Lee, IS
   Cho, SH
   Chae, Y
   Lee, H
AF Cheon, Soyeon
   Zhang, Xiuyu
   Lee, In-Seon
   Cho, Seung-Hun
   Chae, Younbyoung
   Lee, Hyangsook
TI Pharmacopuncture for Cancer Care: A Systematic Review
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID ALTERNATIVE MEDICINE; COMPLEMENTARY; ACUPUNCTURE; MANAGEMENT; INJECTION
AB Background. Pharmacopuncture, injection to acupoints with pharmacological medication or herbal medicine, is a new acupuncture therapy widely available in Korea and China for cancer-related symptoms. However, the evidence is yet to be clear. Objective. To determine pharmacopuncture's effectiveness on cancer-related symptoms. Methods. Eleven databases were searched for randomized controlled trials of pharmacopuncture in cancer patients. The Cochrane risk of bias (ROB) assessment tool was used for quality assessment. Results. Twenty-two studies involving 2,459 patients were included. Five trials of chemotherapy-induced nausea and vomiting (CINV) underwent meta-analysis. Pharmacopuncture significantly relieved severity of CINV compared with control group (3 trials, risk ratio (RR) 1.28, 95% confidence interval (CI) -1.14-1.44). The frequency of CINV was also significantly reduced with pharmacopuncture (2 trials, RR 2.47, 95% CI = 2.12-2.89). Seventeen trials studied various symptoms, and in most studies, pharmacopuncture significantly relieved pain, ileus, hiccup, fever, and gastrointestinal symptoms and improved quality of life in various cancer patients. ROB was generally high. Conclusion. It may be suggested with caution that pharmacopuncture may help various symptom relief in cancer patients, but it is hard to draw a firm conclusion due to clinical heterogeneity and high ROB of the included studies, hence warranting further investigation.
C1 [Cheon, Soyeon; Zhang, Xiuyu; Lee, In-Seon; Chae, Younbyoung] Kyung Hee Univ, Grad Sch, Dept Korean Med Sci, Seoul 130701, South Korea.
   [Cheon, Soyeon; Zhang, Xiuyu; Lee, In-Seon; Chae, Younbyoung; Lee, Hyangsook] Kyung Hee Univ, Coll Korean Med, Acupuncture & Meridian Sci Res Ctr, Seoul 130701, South Korea.
   [Cho, Seung-Hun] Kyung Hee Univ, Med Ctr, Hosp Korean Med, Seoul 130701, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University; Kyung
   Hee University Hospital
RP Lee, H (corresponding author), Kyung Hee Univ, Coll Korean Med, Acupuncture & Meridian Sci Res Ctr, Kyung Hee Dae Ro 26, Seoul 130701, South Korea.
EM erc633@khu.ac.kr
RI Cho, Seung-Hun/F-1294-2010; LEE, HYANGSOOK/D-2070-2017; Chae,
   Younbyoung/AAM-1243-2020; Lee, In-Seon/AAM-1252-2020
OI Cho, Seung-Hun/0000-0002-0627-768X; Cheon, Soyeon/0000-0003-2838-3720;
   LEE, HYANGSOOK/0000-0002-1107-9389; Chae,
   Younbyoung/0000-0001-6787-2215; Lee, In-Seon/0000-0001-9275-3111
FU National Research Foundation of Korea (NRF) - Korean government
   (Ministry of Science, ICT & Future Planning) [2013R1A6A6029251];
   National R & D Program for Cancer Control, Ministry for Health& Welfare,
   Republic of Korea [1020330]
FX This work was supported by the National Research Foundation of Korea
   (NRF) Grant funded by the Korean government (Ministry of Science, ICT &
   Future Planning) (no. 2013R1A6A6029251) and a Grant from the National R
   & D Program for Cancer Control, Ministry for Health& Welfare, Republic
   of Korea (1020330).
CR Anderson JG, 2012, J ALTERN COMPLEM MED, V18, P235, DOI 10.1089/acm.2011.0022
   刘增慧, 2011, [广东医学, Guangdong Medical Journal], V32, P1769
   [Anonymous], HENAN TRADITIONAL CH
   [Anonymous], BMC COMPLEMENTARY S1
   [Anonymous], CHINESE ACUPUNCTURE
   [Anonymous], FAMILY NURSE
   [Anonymous], TRADITIONAL CHINESE
   [Anonymous], CHINESE ACUPUNCTURE
   [Anonymous], J ZHENGZHOU U
   [Anonymous], 1979, WHO HDB REP RES CANC
   [Anonymous], BMC COMPLEMENTARY S1
   [Anonymous], CHINESE FOLK MED
   [Anonymous], CHINESE J MISDIAGNOS
   [Anonymous], J LIAONING U TRADITI
   [Anonymous], CLIN OBSERVATION MEC
   [Anonymous], HUNAN GUIDING J TRAD
   [Anonymous], CHINESE MED HERALD
   [Anonymous], HEBEI J TRADITIONAL
   [Anonymous], CHINESE J PRACTICAL
   [Anonymous], HEBEI MED J
   [Anonymous], CHINESE J NURSING
   [Anonymous], J MATH MED
   [Anonymous], J EMERGENCY TRADITIO
   [Anonymous], EVIDENCE BASED COMPL
   [Anonymous], MODERN REHABILITATIO
   [Anonymous], PHARMACOPUNCTUROLOGY
   [Anonymous], TRADITIONAL CHINESE
   [Anonymous], CHINESE J INFORM TCM
   Arthur K, 2012, INTEGR CANCER THER, V11, P232, DOI 10.1177/1534735411433832
   Bao YJ, 2014, SUPPORT CARE CANCER, V22, P825, DOI 10.1007/s00520-013-2063-5
   Basch E, 2011, J CLIN ONCOL, V29, P4189, DOI [10.1200/JCO.2010.34.4614, 10.1200/JOP.2011.000397]
   Chen J, 2010, BRIT J SURG, V97, P1798, DOI 10.1002/bjs.7227
   Dou Z, 2004, ZHEJIANG J INTEGRATE, V14, P538
   Gansler T, 2010, CA-CANCER J CLIN, V60, P345, DOI 10.3322/caac.20088
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Higgins J., 2011, COCHRANE COLLABORATI
   Higgins JPT, 2002, STAT MED, V21, P1539, DOI [10.1002/sim.1186, 10.1016/j.bandl.2008.10.005]
   [胡定政 Hu Dingzheng], 2003, [中国针灸, Chinese Acupuncture and Moxibustion], V23, P587
   Ioannidis JPA, 2004, ANN INTERN MED, V141, P781, DOI 10.7326/0003-4819-141-10-200411160-00009
   Jemal Ahmedin, 2011, CA Cancer J Clin, V61, P69, DOI 10.3322/caac.20107
   Kim JD, 2010, J ACUPUNCT MERIDIAN, V3, P141, DOI 10.1016/S2005-2901(10)60029-5
   유상민, 2006, Journal of Acupuncture Research, V23, P39
   Loke YK, 2011, Cochrane handbook for systematic reviews of interventions version 510
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   MILLER AB, 1981, CANCER, V47, P207, DOI 10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6
   Park JW, 2012, INTEGR CANCER THER, V11, P166, DOI 10.1177/1534735411413265
   Ripamonti CI, 2011, ANN ONCOL, V22, pvi69, DOI 10.1093/annonc/mdr390
   Schulz KF, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-18
   Siegel R, 2013, CA-CANCER J CLIN, V63, P11, DOI 10.3322/caac.21166
   Song HG, 2009, J PHARMACOPUNCT, V12, P111, DOI 10.3831/KPI.2009.12.4.111
   Spadacio C, 2008, REV SAUDE PUBL, V42, P158, DOI 10.1590/S0034-89102008000100023
   Stewart B., 2015, World cancer report 2014
   Strudwick Mark W, 2007, Acupunct Med, V25, P166
   Weitzel JN, 2011, CA-CANCER J CLIN, V61, P327, DOI 10.3322/caac.20128
   Yan ZM, 2012, QUINTESSENCE INT, V43, P695
   최주영, 2009, Journal of Acupuncture Research, V26, P95
   You Q, 2009, INT J GYNECOL CANCER, V19, P567, DOI 10.1111/IGC.0b013e31819d8b48
NR 57
TC 22
Z9 25
U1 0
U2 18
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2014
VL 2014
AR 804746
DI 10.1155/2014/804746
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AH7BC
UT WOS:000336286300001
PM 24899911
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Ge, XB
   Yue, GL
   Du, GZ
   Fang, X
AF Ge, Xiaobin
   Yue, Gonglei
   Du, Guangzhong
   Fang, Xue
TI Tiny needles, major benefits: acupuncture in child health
SO BMC PEDIATRICS
LA English
DT Article
DE Complementary and alternative medicine; Acupuncture therapy; Pediatrics;
   Disease spectrum; General Hospital
ID ENCEPHALITIS; PAIN; MANAGEMENT; ATTITUDES; SAFETY; STROKE; ILEUS
AB ObjectiveTo retrospectively investigate the utilization patterns and clinical indications of acupuncture within the pediatric population in general hospitals from 2015 to 2020, including disease spectrum characteristics and relevance to pediatric subspecialties.MethodsThe clinical data of pediatric inpatients consulted by Acupuncture-Moxibustion and Tuina Department of Qilu Hospital of Shandong University was collected from January 1, 2015, to December 31, 2020. The data collected include the number of wards in which consultation was requested, the diseases that require consultation, the distribution of pediatric tertiary disciplines and the system of disease affiliation.ResultsThis study summarizes 55 types of pediatric diseases treated with acupuncture. The most common health issues addressed include peripheral facial paralysis, diarrhea, reduced limb mobility or decreased muscle strength, postoperative bloating, and Guillain-Barr & eacute; syndrome. Acupuncture is utilized across all pediatric subdisciplines, with notable applications in neurology, critical care medicine, general surgery, respiratory medicine, and orthopedics. The classification of diseases for acupuncture consultations primarily focuses on disorders of the nervous system, respiratory system, neoplasms, and digestive system (according to ICD-11).ConclusionsIn summary, acupuncture has a broad range of applications in the treatment of pediatric diseases and can serve as a valuable complementary and alternative therapy. The advancement of Traditional Chinese Medicine (TCM) acupuncture in general hospitals is closely linked to the involvement of pediatric practices. The findings of this study provide valuable insights for clinical practice, acupuncture education, pediatric healthcare systems, and social research.
C1 [Ge, Xiaobin; Yue, Gonglei; Du, Guangzhong] Shandong Univ, Qilu Hosp, Dept Acupuncture Moxibust & Tuina, Jinan, Peoples R China.
   [Fang, Xue] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Acupuncture, 42 Wenhua West Rd, Jinan 250011, Shandong, Peoples R China.
C3 Shandong University; Shandong University of Traditional Chinese Medicine
RP Fang, X (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Acupuncture, 42 Wenhua West Rd, Jinan 250011, Shandong, Peoples R China.
EM fangxue0912@163.com
CR Abdullahi AM, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.11174
   Brittner M, 2016, CURR PROB PEDIATR AD, V46, P179, DOI 10.1016/j.cppeds.2015.12.005
   Carville S, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e5765
   Chen YC, 2023, COMPLEMENT THER MED, V78, DOI 10.1016/j.ctim.2023.102988
   Deng JJ, 2017, AM J CHINESE MED, V45, P737, DOI 10.1142/S0192415X17500392
   Ecevit A, 2011, J TRADIT CHIN MED, V31, P308, DOI 10.1016/S0254-6272(12)60009-0
   Ernst E, 2001, AM J MED, V110, P481, DOI 10.1016/S0002-9343(01)00651-9
   Franca RFO, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-016-0628-1
   Ge Xiaobin, 2018, Zhongguo Zhen Jiu, V38, P211, DOI 10.13703/j.0255-2930.2018.02.029
   Gilbey P, 2015, PEDIATR ANESTH, V25, P603, DOI 10.1111/pan.12621
   Gold JI, 2009, EVID-BASED COMPL ALT, V6, P429, DOI 10.1093/ecam/nem181
   Gottschling S, 2008, PAIN, V137, P405, DOI 10.1016/j.pain.2007.10.004
   [胡琳娜 Hu Linna], 2010, [中国组织工程研究与临床康复, Journal of Clinical Rehabilitative Tissue Engineering Research], V14, P8662
   Keefe KR, 2018, LARYNGOSCOPE, V128, P2625, DOI 10.1002/lary.27231
   Kelly D, 2013, ADV EXP MED BIOL, V764, P133, DOI 10.1007/978-1-4614-4726-9_10
   Kim KS, 2006, PEDIATR ANESTH, V16, P1036, DOI 10.1111/j.1460-9592.2006.01927.x
   Lai SR, 2025, CLIN PEDIATR, V64, P719, DOI 10.1177/00099228241283279
   Li PP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121880
   Lima-De Armas B, 2016, REV NEUROLOGIA, V62, P239, DOI 10.33588/rn.6205.2015497
   Lin RH, 2017, EXP THER MED, V14, P2373, DOI 10.3892/etm.2017.4750
   Lin Y, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000023953
   Mano KEJ, 2009, J ALTERN COMPLEM MED, V15, P661, DOI 10.1089/acm.2008.0449
   Piao HL, 2023, NEUROREHABILITATION, V53, P161, DOI 10.3233/NRE-230006
   Pintov S, 1997, PEDIATR NEUROL, V17, P129, DOI 10.1016/S0887-8994(97)00086-6
   Romero-García PA, 2024, HEALTHCARE-BASEL, V12, DOI 10.3390/healthcare12151547
   Sertel S, 2009, EUR ARCH OTO-RHINO-L, V266, P919, DOI 10.1007/s00405-008-0851-1
   Skjeie H, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-009486
   [孙超 Sun Chao], 2021, [中医杂志, Journal of Traditional Chinese Medicine], V62, P1343
   Tan L, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/6611461
   Tunkel AR, 2008, CLIN INFECT DIS, V47, P303, DOI 10.1086/589747
   Vather R, 2014, CLIN EXP PHARMACOL P, V41, P358, DOI 10.1111/1440-1681.12220
   Wang SY, 2017, MED ACUPUNCT, V29, P322, DOI 10.1089/acu.2017.1231
   Wen H, Inner Mongolia J Traditional Chin Med, V06, P92
   Wu S, 2009, PEDIATR CRIT CARE ME, V10, P291, DOI 10.1097/PCC.0b013e318198afd6
   Xu Kai-Sheng, 2014, Zhongguo Zhen Jiu, V34, P529
   Yan TB, 2009, J REHABIL MED, V41, P312, DOI 10.2340/16501977-0325
   Yang CS, 2015, PEDIATR RES, V78, P112, DOI 10.1038/pr.2015.91
   Yang NN, 2020, NEUROGASTROENT MOTIL, V32, DOI 10.1111/nmo.13808
   Yao Y, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5549006
   Zhao JG, 2009, J NEUROL SCI, V276, P143, DOI 10.1016/j.jns.2008.09.018
   Ziodeen KA, 2018, COMPLEMENT THER MED, V37, P133, DOI 10.1016/j.ctim.2018.02.004
NR 41
TC 0
Z9 0
U1 2
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD APR 14
PY 2025
VL 25
IS 1
AR 290
DI 10.1186/s12887-025-05586-9
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 1NW6K
UT WOS:001469477000003
PM 40223074
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, ZY
   Liu, CZ
   Pei, W
   Zhang, TZ
   Zhang, J
   Fan, WW
   Wei, XY
   Tu, JF
   Wang, L
   Wang, X
   Yang, NN
AF Wang, Ze-Yi
   Liu, Cun-Zhi
   Pei, Wei
   Zhang, Tian-Zhen
   Zhang, Jing
   Fan, Wen-Wen
   Wei, Xiao-Ya
   Tu, Jian-Feng
   Wang, Lu
   Wang, Xu
   Yang, Na-Na
TI Investigating the efficacy of electroacupuncture for postoperative ileus
   in patients with colorectal cancer: study protocol for a multicentre
   clinical trial with neuroimaging assessment
SO BMJ OPEN
LA English
DT Article
DE Acupuncture; Functional bowel disorders; Motility disorders; Colorectal
   surgery; Functional Magnetic Resonance Imaging; COMPLEMENTARY MEDICINE
ID OPIOID RECEPTOR ANTAGONIST; GASTRIC-CANCER; GASTRECTOMY; SURGERY;
   ALVIMOPAN; FMRI; CONNECTIVITY; ACUPUNCTURE; NETWORK; PAIN
AB Introduction Postoperative ileus (POI) is a prevalent complication following abdominal surgeries, significantly compromising patients' quality of life and imposing a socioeconomic burden. Electroacupuncture (EA), a widely used therapeutic approach in China, has shown promise as an effective intervention for POI. However, the neural mechanism underlying its therapeutic effects remains unclear. Thus, this study aims to evaluate the efficacy of EA treatment for POI and investigate its central mechanism by functional MRI (fMRI).Methods and analysis This randomised controlled clinical trial will be conducted across three hospitals in China. A total of 50 eligible patients with colorectal cancer scheduled for elective laparoscopic surgery will be randomly assigned to either the EA or sham electroacupuncture (SA) group in a 1:1 ratio. All patients will undergo 5 sessions of 30 min EA or SA over 5 consecutive days post-surgery (once daily). Resting-state fMRI (rs-fMRI) scans will be performed at baseline and the end of treatment to examine brain functional changes related to EA treatment. The primary outcome is the time to first defecation. Secondary outcomes include the time to first flatus, ambulation, tolerability of semiliquid and solid food; length of postoperative hospital stay; severity of postoperative pain, abdominal distension and nausea; frequency of postoperative nausea and vomiting episodes; rate of readmission. Postoperative complications will be monitored and documented throughout the trial duration. Credibility and expectancy evaluation, along with blinding assessment, will be conducted after the first treatment session. Pearson/Spearman correlation analysis will be performed to determine the relationship between clinical variables and rs-fMRI metrics.Ethics and dissemination This protocol has been approved by the ethics committees of Beijing University of Chinese Medicine (number 2024BZYLL0113), Cancer Hospital Chinese Academy of Medical Sciences (number 24/323-4603), Beijing Friendship Hospital Affiliated to Capital Medical University (number 2024-P2-081-01) and Beijing Chaoyang Huanxing Cancer Hospital (number 2024-011-02). Participants will sign the paper-based informed consent form before enrolment. The results will be disseminated through peer-reviewed publications.Trial registration number ITMCTR2024000504.
C1 [Wang, Ze-Yi; Liu, Cun-Zhi; Wei, Xiao-Ya; Tu, Jian-Feng; Wang, Lu; Yang, Na-Na] Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
   [Pei, Wei] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Colorectal Surg,Canc Hosp, Beijing, Peoples R China.
   [Zhang, Tian-Zhen] Capital Med Univ, Affiliated Beijing Friendship Hosp, Dept Gen Surg, Beijing, Peoples R China.
   [Zhang, Tian-Zhen] Natl Clin Res Ctr Digest Dis, Beijing, Peoples R China.
   [Zhang, Tian-Zhen] Capital Med Univ, State Key Lab Digest Hlth, Affiliated Beijing Friendship Hosp, Beijing, Peoples R China.
   [Zhang, Jing] Huanxing Canc Hosp, Dept Surg, Beijing, Peoples R China.
   [Fan, Wen-Wen] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Dept Radiol,Natl Canc Ctr,Natl Clin Res Ctr, Beijing, Peoples R China.
   [Wang, Xu] Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College;
   Cancer Institute & Hospital - CAMS; Capital Medical University; Capital
   Medical University; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Cancer Institute & Hospital - CAMS; Peking Union
   Medical College; Beijing University of Chinese Medicine
RP Yang, NN (corresponding author), Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.; Wang, X (corresponding author), Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China.
EM 18810201536@163.com; lcz623780@126.com; peiwei@cicams.ac.cn;
   tianzhen_zhang@126.com; 13436383665@163.com; 2024.fwwhy@163.com;
   xiaoya0414@vip.qq.com; tujianfeng1@126.com; wanglucomeonctgu@163.com;
   wangx@bucm.edu.cn; 1254614551@qq.com
RI Tu, Jian-Feng/J-7768-2017; Liu, Cunzhi/J-9190-2017; Fan,
   Wenwen/HJY-9622-2023; Pei, Wei/HNC-0257-2023
FU National Natural Science Foundation of China [82330126]
FX This work is supported by the National Natural Science Foundation of
   China (Grant No. 82330126).
CR Artinyan A, 2008, WORLD J SURG, V32, P1495, DOI 10.1007/s00268-008-9491-2
   Asgeirsson T, 2010, J AM COLL SURGEONS, V210, P228, DOI 10.1016/j.jamcollsurg.2009.09.028
   Barkhof F, 2014, RADIOLOGY, V272, P28, DOI 10.1148/radiol.14132388
   Basaia S, 2020, NEUROLOGY, V95, pE2552, DOI 10.1212/WNL.0000000000010731
   Buscail E, 2022, BRIT J PHARMACOL, V179, P3283, DOI 10.1111/bph.15800
   Cao J, 2020, NEUROIMAGE, V221, DOI 10.1016/j.neuroimage.2020.117176
   Chae HD, 2016, J ALTERN COMPLEM MED, V22, P465, DOI 10.1089/acm.2015.0161
   Chapman SJ, 2018, BRIT J SURG, V105, P797, DOI 10.1002/bjs.10781
   Chen HT, 2024, INT J SURG, V110, P1113, DOI 10.1097/JS9.0000000000000848
   Chen KB, 2019, INT J SURG, V70, P93, DOI 10.1016/j.ijsu.2019.08.034
   Chen KB, 2018, WORLD J GASTRO SURG, V10, P13, DOI 10.4240/wjgs.v10.i2.13
   Desmond JE, 2002, J NEUROSCI METH, V118, P115, DOI 10.1016/S0165-0270(02)00121-8
   Devilly GJ, 2000, J BEHAV THER EXP PSY, V31, P73, DOI 10.1016/S0005-7916(00)00012-4
   Dindo D, 2004, ANN SURG, V240, P205, DOI [10.17116/hirurgia2018090162, 10.1097/01.sla.0000133083.54934.ae]
   Ditzel FL, 2023, BRIT J ANAESTH, V130, pE281, DOI 10.1016/j.bja.2022.07.054
   Drake TM, 2016, J GASTROINTEST SURG, V20, P1253, DOI 10.1007/s11605-016-3140-0
   FRISTON KJ, 1993, J CEREBR BLOOD F MET, V13, P5, DOI 10.1038/jcbfm.1993.4
   Gkegkes ID, 2020, DIGEST SURG, V37, P22, DOI 10.1159/000496431
   Guo CH, 2025, SCI REP-UK, V15, DOI 10.1038/s41598-025-99406-w
   Harnsberger CR, 2019, CLIN COLON RECT SURG, V32, P166, DOI 10.1055/s-0038-1677003
   Hawker GA, 2011, ARTHRIT CARE RES, V63, pS240, DOI 10.1002/acr.20543
   Hou YQ, 2019, TRIALS, V20, DOI 10.1186/s13063-018-3051-3
   Irving G, 2011, J PAIN, V12, P175, DOI 10.1016/j.jpain.2010.06.013
   Jia WD, 2019, ASIAN J SURG, V42, P11, DOI 10.1016/j.asjsur.2018.01.007
   Jiang S, 2024, NUCLEIC ACIDS RES, V53, pD1670, DOI 10.1093/nar/gkae973
   Jovicich J, 2016, NEUROIMAGE, V124, P442, DOI 10.1016/j.neuroimage.2015.07.010
   Jung SY, 2017, J GASTRIC CANCER, V17, P11
   Kauf TL, 2014, J UROLOGY, V191, P1721, DOI 10.1016/j.juro.2013.12.015
   Kehlet H, 2008, NAT CLIN PRACT GASTR, V5, P552, DOI 10.1038/ncpgasthep1230
   Keller DS, 2016, AM J SURG, V212, P851, DOI 10.1016/j.amjsurg.2016.02.016
   Kong Q, 2024, INT J SURG, V110, P5713, DOI 10.1097/JS9.0000000000001641
   Kraft MD, 2008, EXPERT OPIN INV DRUG, V17, P1365, DOI 10.1517/13543784.17.9.1365 
   Landrum Laurie, 2006, Qual Manag Health Care, V15, P83
   Lee IS, 2016, NEUROGASTROENT MOTIL, V28, P793, DOI 10.1111/nmo.12793
   Li ZJ, 2014, FORSCH KOMPLEMENTMED, V21, P99, DOI 10.1159/000360804
   Liu PH, 2020, J AFFECT DISORDERS, V273, P95, DOI 10.1016/j.jad.2020.03.107
   Liu Q, 2017, INT J SURG, V47, P107, DOI 10.1016/j.ijsu.2017.07.107
   Liu YH, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/3178472
   Logothetis NK, 2008, NATURE, V453, P869, DOI 10.1038/nature06976
   Ma K, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.608688
   Mumford JA, 2008, NEUROIMAGE, V39, P261, DOI 10.1016/j.neuroimage.2007.07.061
   Pei LX, 2025, GASTROENTEROLOGY, V169, P73, DOI [10.1053/j.gastro.2025.02.006, 10.1053/j.gastro.2025.02.006]
   Qin RJ, 2025, ACUPUNCT HERB MED, V5, P36, DOI 10.1097/HM9.0000000000000142
   Qiu K, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/3685785
   Ravikumar R, 2017, BMJ-BRIT MED J, V357, DOI 10.1136/bmj.j1455
   Reichert M, 2024, INT J SURG, V110, P4329, DOI 10.1097/JS9.0000000000001393
   Rollins KE, 2019, ANN SURG, V270, P43, DOI 10.1097/SLA.0000000000003145
   Stakenborg N, 2017, HANDB EXP PHARMACOL, V239, P39, DOI 10.1007/164_2016_108
   Sultan S, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012111.pub2
   Sun RR, 2021, BRAIN IMAGING BEHAV, V15, P216, DOI 10.1007/s11682-019-00249-7
   Teixeira FM, 2012, BRAZ J MED BIOL RES, V45, P1209, DOI 10.1590/S0100-879X2012007500133
   van Bree SHW, 2014, ANN SURG, V259, P708, DOI 10.1097/SLA.0b013e318293ee55
   van Bree SHW, 2012, NAT REV GASTRO HEPAT, V9, P675, DOI 10.1038/nrgastro.2012.134
   Vilz TO, 2017, DTSCH ARZTEBL INT, V114, P508, DOI 10.3238/arztebl.2017.0508
   Wang L, 2024, BMC GASTROENTEROL, V24, DOI 10.1186/s12876-024-03124-y
   Wang Y, 2023, JAMA SURG, V158, P20, DOI 10.1001/jamasurg.2022.5674
   Wang YW, 2023, NEUROIMAGE, V274, DOI 10.1016/j.neuroimage.2023.120089
   Wu ZQ, 2015, EUR SURG RES, V54, P127, DOI 10.1159/000369529
   Yang H, 2007, NEUROIMAGE, V36, P144, DOI 10.1016/j.neuroimage.2007.01.054
   Yang JW, 2022, ECLINICALMEDICINE, V49, DOI 10.1016/j.eclinm.2022.101472
   Yang NN, 2021, THERANOSTICS, V11, P4078, DOI 10.7150/thno.52574
   You XL, 2018, J CANCER, V9, P2266, DOI 10.7150/jca.24767
   Yu MC, 2018, HUM BRAIN MAPP, V39, P4213, DOI 10.1002/hbm.24241
   Yu Z, 2020, WORLD J GASTROENTERO, V26, DOI 10.3748/wjg.v26.i23.3182
   Yuan L, 2024, J GASTROEN HEPATOL, V39, P2060, DOI 10.1111/jgh.16670
   Zang YF, 2004, NEUROIMAGE, V22, P394, DOI 10.1016/j.neuroimage.2003.12.030
   Zennami K, 2024, BJU INT, V134, P426, DOI 10.1111/bju.16340
   Zhao TT, 2021, FRONT HUM NEUROSCI, V15, DOI 10.3389/fnhum.2021.736512
   Zhou JZ, 2017, NEUROMODULATION, V20, P767, DOI 10.1111/ner.12602
   Zhou KH, 2011, J ALTERN COMPLEM MED, V17, P1007, DOI 10.1089/acm.2010.0652
   Zou X, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-050000
NR 71
TC 0
Z9 0
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD DEC 31
PY 2025
VL 15
IS 12
AR e108722
DI 10.1136/bmjopen-2025-108722
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AM4LU
UT WOS:001651591400001
PM 41475813
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Garcia, MK
   Driver, L
   Haddad, R
   Lee, R
   Palmer, JL
   Wei, Q
   Frenkel, M
   Cohen, L
AF Garcia, M. Kay
   Driver, Larry
   Haddad, Robin
   Lee, Richard
   Palmer, J. Lynn
   Wei, Qi
   Frenkel, Moshe
   Cohen, Lorenzo
TI Acupuncture for Treatment of Uncontrolled Pain in Cancer Patients: A
   Pragmatic Pilot Study
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; pain; cancer; complementary medicine; integrative medicine;
   symptom management
ID AURICULAR ACUPUNCTURE
AB Purpose. Pain control is an ongoing challenge in the oncology setting. Prior to implementing a large randomized trial at our institution, we investigated the feasibility, safety, and initial efficacy of acupuncture for uncontrolled pain among cancer patients. Hypotheses. Our hypotheses were that the acupuncture treatments provided would be (a) feasible, (b) safe, and (c) a beneficial adjunct to pain management. Study Design. This was a single arm, nonrandomized pragmatic pilot study. Methods. Participants experiencing pain 4 on a 0 to 10 numeric rating scale received a maximum of 10 treatments on an individualized basis. Recruitment, attrition, compliance, and adverse events (AEs) were assessed. Pain (Brief Pain Inventory-Short Form), quality of life (MD Anderson Symptom Inventory [MDASI]), and patient satisfaction were assessed at baseline and at the end of treatment. Results. Of 115 patients screened, 52 (45%) were eligible and agreed to participate. Eleven (21%) were lost to follow-up, leaving 41 who completed all study procedures. No AEs were reported. Mean pain severity was 6.0 +/- 1.3 at baseline and 3.8 +/- 2.0 at follow-up (P < .0001). Pain interference was 6.2 +/- 2.3 at baseline and 4.3 +/- 2.8 at follow-up (P < .0011). On the MDASI, the mean symptom severity was 4.6 +/- 1.8 at baseline and 3.2 +/- 1.9 at follow-up (P < .0001), and mean symptom interference was 5.8 +/- 2.4 at baseline and 4.1 +/- 2.9 at follow-up (P < .002). Prescribed pain medications decreased across the course of the study. Patient satisfaction was high: 87% reported that their expectations were met very well or extremely well; 90% said they were likely to participate again; 95% said they were likely to recommend acupuncture to others; and 90% reported they found the service to be useful or very useful. Conclusions. Acupuncture was feasible, safe, and a helpful treatment adjunct for cancer patients experiencing uncontrolled pain in this study. Randomized placebo-controlled trials are needed to confirm these results.
C1 [Garcia, M. Kay; Driver, Larry; Haddad, Robin; Lee, Richard; Palmer, J. Lynn; Wei, Qi; Cohen, Lorenzo] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Frenkel, Moshe] Meir Med Ctr, Integrat Oncol Serv, Inst Oncol, Kefar Sava, Israel.
C3 University of Texas System; UTMD Anderson Cancer Center; Tel Aviv
   University; Sackler Faculty of Medicine
RP Garcia, MK (corresponding author), Univ Texas MD Anderson Canc Ctr, Integrat Med Program, 1515 Holcombe Blvd,Unit 0462, Houston, TX 77030 USA.
EM kaygarcia@mdanderson.org
RI Lee, Richard/AAS-1416-2021; Wei, Qi/JJF-3393-2023
OI Lee, Richard/0000-0001-9916-6155; 
FU United States National Cancer Institute (NCI) [CA121503]; NCI Cancer
   Center [CA016672]; University of Texas MD Anderson Cancer Center;
   National Cancer Institute [P30CA016672] Funding Source: NIH RePORTER
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Support
   was provided in part by the United States National Cancer Institute
   (NCI) grant CA121503, the NCI Cancer Center Support Grant CA016672, and
   The University of Texas MD Anderson Cancer Center.
CR Alimi D, 2000, J PAIN SYMPTOM MANAG, V19, P81, DOI 10.1016/S0885-3924(99)00140-2
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   [Anonymous], ACUPUNCTURE ENERGETI
   Atkinson TM, 2010, PAIN MED, V11, P337, DOI 10.1111/j.1526-4637.2009.00774.x
   Burton Allen W, 2012, J Support Oncol, V10, P89, DOI 10.1016/j.suponc.2011.08.004
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Cleeland CS, 2000, CANCER-AM CANCER SOC, V89, P1634, DOI 10.1002/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO;2-V
   Dedman P, 1998, MANUAL ACUPUNCTURE
   Deng L, 1997, CHINESE ACUPUNCTURE
   Ernst E, 2001, AM J MED, V110, P481, DOI 10.1016/S0002-9343(01)00651-9
   Ernst G, 2003, COMPLEMENT THER MED, V11, P93, DOI 10.1016/S0965-2299(03)00004-9
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Grisold W, 2012, NEURO-ONCOLOGY, V14, P45, DOI 10.1093/neuonc/nos203
   HAN JS, 1980, AM J CHINESE MED, V8, P331, DOI 10.1142/S0192415X80000311
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   Huang LC., 1996, Auriculotherapy, diagnosis and treatment
   Huang WJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032960
   Kaptchuk TJ, 2011, PHILOS T R SOC B, V366, P1849, DOI 10.1098/rstb.2010.0385
   Lao Lixing, 2006, J Soc Integr Oncol, V4, P13
   Lao LX, 2003, ALTERN THER HEALTH M, V9, P72
   Lee H, 2005, EUR J PAIN, V9, P437, DOI 10.1016/j.ejpain.2004.10.004
   MacPherson H, 2001, Acupunct Med, V19, P93
   MacPherson Hugh, 2005, Acupunct Med, V23, P112
   Mittleman E, 2000, J AM VET MED ASSOC, V217, P1201, DOI 10.2460/javma.2000.217.1201
   Niemtzow RC, 2006, J ALTERN COMPLEM MED, V12, P597, DOI 10.1089/acm.2006.597
   Paley CA, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub2
   Peng Hao, 2010, Zhong Xi Yi Jie He Xue Bao, V8, P501
   Sherman Karen J, 2009, J Clin Outcomes Manag, V16, P224
   Ulett GA, 2003, AM J PUBLIC HEALTH, V93, P1037, DOI 10.2105/AJPH.93.7.1037
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
NR 32
TC 23
Z9 26
U1 0
U2 29
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD MAR
PY 2014
VL 13
IS 2
BP 133
EP 140
DI 10.1177/1534735413510558
PG 8
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA AB1KF
UT WOS:000331549700005
PM 24282103
OA gold
DA 2026-01-16
ER

PT J
AU Burnstock, G
AF Burnstock, G.
TI Purinergic signalling in the lower urinary tract
SO ACTA PHYSIOLOGICA
LA English
DT Review
DE acupuncture; ATP; bladder; cancer; prostate; ureter
ID P2X(3) RECEPTOR EXPRESSION; PROSTATE-CANCER CELLS; ATP RELEASE; HUMAN
   BLADDER; IN-VITRO; ADENOSINE-TRIPHOSPHATE; EXTRACELLULAR NUCLEOTIDES;
   BOTULINUM NEUROTOXIN; GROWTH-STIMULATION; ACTIVATION
AB The aim of this review is to describe the conceptual steps contributing to our current knowledge of purinergic signalling and to consider its involvement in the physiology and pathophysiology of the lower urinary tract. The voiding reflex involves ATP released as a cotransmitter with acetylcholine from parasympathetic nerves supplying the bladder and ATP released from urothelial cells during bladder distension to initiate the voiding reflex via P2X3 receptors on suburothelial low threshold sensory nerve fibres. This mechanosensory transduction pathway also participates, via high threshold sensory nerve fibres, in the initiation of pain in bladder and ureter. Treatment of prostate and bladder cancer with ATP is effective against the primary tumours in animal models and human cell lines, via P2X5 and P2X7 receptors, and also improves the systemic symptoms associated with advanced malignancy. Acupuncture is widely used for the treatment of urinary disorders, and a purinergic hypothesis is discussed for the underlying mechanism.
C1 UCL, Sch Med, Autonom Neurosci Ctr, London NW3 2PF, England.
C3 University of London; University College London; UCL Medical School
RP Burnstock, G (corresponding author), UCL, Sch Med, Autonom Neurosci Ctr, Rowland Hill St, London NW3 2PF, England.
EM g.burnstock@ucl.ac.uk
RI Burnstock, Geoffrey/AFR-8604-2022
CR Abraham EH, 2003, CURR TOP MEMBR, V54, P415, DOI 10.1016/S1063-5823(03)01013-5
   Agteresch HJ, 2000, J NATL CANCER I, V92, P321, DOI 10.1093/jnci/92.4.321
   Agteresch HJ, 2000, EUR J CLIN PHARMACOL, V56, P49, DOI 10.1007/s002280050719
   Andersson KE, 2002, UROLOGY, V60, P13, DOI 10.1016/S0090-4295(02)01786-7
   Artim DE, 2007, FASEB J, V21, pA1349
   Baqi Y, 2009, PURINERG SIGNAL, V5, P91, DOI 10.1007/s11302-008-9103-5
   Birder LA, 2004, AM J PHYSIOL-RENAL, V287, pF1084, DOI 10.1152/ajprenal.00118.2004
   Bo XN, 1999, NEUROREPORT, V10, P1107, DOI 10.1097/00001756-199904060-00037
   Boissier S, 1997, CANCER RES, V57, P3890
   BURNSTOCK G, 1972, BRIT J PHARMACOL, V44, P451, DOI 10.1111/j.1476-5381.1972.tb07283.x
   Burnstock G, 2007, CELL MOL LIFE SCI, V64, P1471, DOI 10.1007/s00018-007-6497-0
   BURNSTOCK G, 1978, BRIT J PHARMACOL, V63, P125, DOI 10.1111/j.1476-5381.1978.tb07782.x
   BURNSTOCK G, 1976, NEUROSCIENCE, V1, P239, DOI 10.1016/0306-4522(76)90054-3
   Burnstock G, 2010, CELL DEATH DIS, V1, DOI 10.1038/cddis.2009.11
   Burnstock G, 2009, ACTA PHYSIOL, V195, P415, DOI 10.1111/j.1748-1716.2009.01957.x
   Burnstock G, 2001, HANDB EXP PHARM, V151, P423
   BURNSTOCK G, 1985, GEN PHARMACOL, V16, P433, DOI 10.1016/0306-3623(85)90001-1
   Burnstock G, 1999, J ANAT, V194, P335, DOI 10.1046/j.1469-7580.1999.19430335.x
   BURNSTOCK G, 1972, PHARMACOL REV, V24, P509
   Burnstock G, 2001, TRENDS PHARMACOL SCI, V22, P182, DOI 10.1016/S0165-6147(00)01643-6
   Burnstock G, 2004, INT REV CYTOL, V240, P31, DOI 10.1016/S0074-7696(04)40002-3
   Burnstock G., 2009, ASPECTS PHARM PYELOU, P77
   Burnstock G., 1978, CELL MEMBRAIN RECEPT, P107
   Burnstock G, 2007, PHYSIOL REV, V87, P659, DOI 10.1152/physrev.00043.2006
   Burnstock G, 2009, MOL PAIN, V5, DOI 10.1186/1744-8069-5-69
   Burnstock G, 2009, MED HYPOTHESES, V73, P470, DOI 10.1016/j.mehy.2009.05.031
   Calvert RC, 2008, PURINERG SIGNAL, V4, P377, DOI 10.1007/s11302-008-9123-1
   Chancellor MB, 2008, NAT CLIN PRACT UROL, V5, P319, DOI 10.1038/ncpuro1124
   CHEN CC, 1995, NATURE, V377, P428, DOI 10.1038/377428a0
   Chen L, 2004, CANCER LETT, V215, P239, DOI 10.1016/j.canlet.2004.05.023
   Chen XW, 2010, J NEUROSCI, V30, P2365, DOI 10.1523/JNEUROSCI.5462-09.2010
   Cheng Y, 2010, J UROLOGY, V183, P1082, DOI 10.1016/j.juro.2009.11.028
   Cockayne DA, 2000, NATURE, V407, P1011, DOI 10.1038/35039519
   Dainty I. A., 1995, BR J PHARM, V114, p106P
   Donnelly-Roberts DL, 2007, BRIT J PHARMACOL, V151, P571, DOI 10.1038/sj.bjp.0707265
   Engberg S, 2009, J WOUND OSTOMY CONT, V36, P661, DOI 10.1097/WON.0b013e3181bd82dd
   FANG WG, 1992, J CLIN INVEST, V89, P191, DOI 10.1172/JCI115562
   Feng LL, 2011, NEOPLASIA, V13, P206, DOI 10.1593/neo.101332
   Fernando KC, 1999, ARCH BIOCHEM BIOPHYS, V362, P197, DOI 10.1006/abbi.1998.1045
   Ford APDW, 2006, BRIT J PHARMACOL, V147, pS132, DOI 10.1038/sj.bjp.0706637
   Gever JR, 2006, PFLUG ARCH EUR J PHY, V452, P513, DOI 10.1007/s00424-006-0070-9
   Gever JR, 2010, BRIT J PHARMACOL, V160, P1387, DOI 10.1111/j.1476-5381.2010.00796.x
   Ghiringhelli F, 2009, NAT MED, V15, P1170, DOI 10.1038/nm.2028
   Greig AVH, 2003, J INVEST DERMATOL, V121, P315, DOI 10.1046/j.1523-1747.2003.12379.x
   Harvey RA, 2002, J UROLOGY, V168, P1235, DOI 10.1016/S0022-5347(05)64632-0
   Heppner TJ, 2009, J PHYSIOL-LONDON, V587, P5275, DOI 10.1113/jphysiol.2009.178806
   HOYLE CHV, 1989, EUR J PHARMACOL, V174, P115, DOI 10.1016/0014-2999(89)90881-9
   Ito K, 2008, N-S ARCH PHARMACOL, V377, P483, DOI 10.1007/s00210-007-0197-z
   Jajoo S, 2009, NEOPLASIA, V11, P1132, DOI 10.1593/neo.09744
   Janssens R, 2001, BRIT J PHARMACOL, V132, P536, DOI 10.1038/sj.bjp.0703833
   Kaan TKY, 2010, J NEUROSCI, V30, P4503, DOI 10.1523/JNEUROSCI.6132-09.2010
   KASAKOV L, 1982, EUR J PHARMACOL, V86, P291, DOI 10.1016/0014-2999(82)90330-2
   Knight GE, 2002, AM J PHYSIOL-RENAL, V282, pF281, DOI 10.1152/ajprenal.00293.2000
   KOISO K, 1991, UROL INT, V46, P145, DOI 10.1159/000282120
   Korcok J, 2004, J BONE MINER RES, V19, P642, DOI 10.1359/JBMR.040108
   KYPRIANOU N, 1989, BIOCHEM BIOPH RES CO, V165, P73, DOI 10.1016/0006-291X(89)91035-8
   Lawrence GW, 2010, J PHARMACOL EXP THER, V334, P1080, DOI 10.1124/jpet.110.169342
   LEE YH, 1992, J UROLOGY, V147, P16, DOI 10.1016/S0022-5347(17)37121-5
   LEWIS C, 1995, NATURE, V377, P432, DOI 10.1038/377432a0
   MACKENZIE I, 1982, NEUROSCIENCE, V7, P997, DOI 10.1016/0306-4522(82)90056-2
   MARTIKAINEN P, 1991, CANCER RES, V51, P4693
   Martins I, 2009, CELL CYCLE, V8, P3723, DOI 10.4161/cc.8.22.10026
   Martins JP, 2012, BRIT J PHARMACOL, V165, P183, DOI 10.1111/j.1476-5381.2011.01535.x
   McCarthy CJ, 2009, J UROLOGY, V181, P1459, DOI 10.1016/j.juro.2008.10.139
   Minelli A, 2006, PROSTATE, V66, P1425, DOI 10.1002/pros.20458
   Minelli A, 2009, PROSTATE, V69, P538, DOI 10.1002/pros.20900
   Miyake H, 1999, J UROLOGY, V162, P916, DOI 10.1097/00005392-199909010-00090
   Mochizuki T, 2009, J BIOL CHEM, V284, P21257, DOI 10.1074/jbc.M109.020206
   Mönkkönen H, 2008, ANTI-CANCER DRUG, V19, P391, DOI 10.1097/CAD.0b013e3282f632bf
   Moore KH, 2001, J NEUROSCI, V21, DOI 10.1523/JNEUROSCI.21-18-j0002.2001
   Nandigama R, 2006, J BIOL CHEM, V281, P5686, DOI 10.1074/jbc.M510452200
   NERGARDH A, 1981, SCAND J UROL NEPHROL, V15, P103, DOI 10.3109/00365598109179584
   Nishiguchi J, 2004, EUR J NEUROSCI, V20, P474, DOI 10.1111/j.1460-9568.2004.03508.x
   Nucciarelli F, 2003, DRUG DEVELOP RES, V58, P390, DOI 10.1002/ddr.10183
   O'Reilly BA, 2002, J UROLOGY, V167, P157, DOI 10.1016/S0022-5347(05)65403-1
   O'Reilly BA, 2001, BJU INT, V87, P617, DOI 10.1046/j.1464-410x.2001.02179.x
   PALEA S, 1993, J UROLOGY, V150, P2007, DOI 10.1016/S0022-5347(17)35955-4
   Phelps PT, 2006, EUR J PHARMACOL, V536, P28, DOI 10.1016/j.ejphar.2006.02.046
   Ralevic V, 1998, PHARMACOL REV, V50, P413
   RAPAPORT E, 1983, J CELL PHYSIOL, V114, P279, DOI 10.1002/jcp.1041140305
   Rocha I, 2001, AUTON NEUROSCI-BASIC, V88, P6, DOI 10.1016/S1566-0702(00)00284-8
   Rong WF, 2000, J PHYSIOL-LONDON, V524, P891, DOI 10.1111/j.1469-7793.2000.00891.x
   Rong WF, 2004, NEUROPHARMACOLOGY, V47, P1093, DOI 10.1016/j.neuropharm.2004.08.003
   Ryten M, 2002, J CELL BIOL, V158, P345, DOI 10.1083/jcb.200202025
   Sauer H, 2002, J CELL SCI, V115, P3265
   Shabbir M, 2008, BJU INT, V102, P108, DOI 10.1111/j.1464-410X.2008.07578.x
   Shabbir M, 2008, BJU INT, V101, P352, DOI 10.1111/j.1464-410X.2007.07293.x
   Shabbir M, 2008, BJU INT, V101, P106, DOI 10.1111/j.1464-410X.2007.07286.x
   Shabbir M, 2009, INT J UROL, V16, P143, DOI 10.1111/j.1442-2042.2008.02207.x
   Shemon AN, 2006, J BIOL CHEM, V281, P2079, DOI 10.1074/jbc.M507816200
   SIBLEY GNA, 1984, J PHYSIOL-LONDON, V354, P431, DOI 10.1113/jphysiol.1984.sp015386
   Slater M, 2004, HISTOPATHOLOGY, V44, P206, DOI 10.1111/j.0309-0167.2004.01798.x
   Smith CP, 2005, NEUROCHEM INT, V47, P291, DOI 10.1016/j.neuint.2005.04.021
   Smith DJ., 1994, NEUROUROL URODYNAM, V13, P414
   Soe SHTE, 2009, MULT SCLER J, V15, P1376, DOI 10.1177/1352458509107020
   Stagg J, 2010, ONCOGENE, V29, P5346, DOI 10.1038/onc.2010.292
   Stella J, 2010, UROL ONCOL-SEMIN ORI, V28, P260, DOI 10.1016/j.urolonc.2009.01.035
   Sugaya K, 2009, BIOMED RES-TOKYO, V30, P287, DOI 10.2220/biomedres.30.287
   Sun Y, 2001, Urology, V57, P131, DOI 10.1016/S0090-4295(01)01106-2
   Sun Y, 2004, J UROLOGY, V171, P448, DOI 10.1097/01.ju.0000099660.46774.3c
   Tapia-Vieyra JV, 2001, ARCH MED RES, V32, P175, DOI 10.1016/S0188-4409(01)00274-0
   Tempest HV, 2004, BJU INT, V93, P1344, DOI 10.1111/j.1464-410X.2004.04858.x
   Tong YQ, 2009, J ALTERN COMPLEM MED, V15, P905, DOI 10.1089/acm.2009.0062
   van der Weyden L, 2000, HYPERTENSION, V36, P1093, DOI 10.1161/01.HYP.36.6.1093
   Vanoverberghe K, 2003, CELL CALCIUM, V34, P75, DOI 10.1016/S0143-4160(03)00024-1
   Vlaskovska M, 2001, J NEUROSCI, V21, P5670, DOI 10.1523/JNEUROSCI.21-15-05670.2001
   Wang QF, 2004, ENDOCRINOLOGY, V145, P5568, DOI 10.1210/en.2004-0807
   Wasilenko WJ, 1997, PROSTATE, V30, P167
   Wei Q, 2011, BIOCHEM PHARMACOL, V82, P418, DOI 10.1016/j.bcp.2011.05.013
   White N, 2006, TRENDS PHARMACOL SCI, V27, P211, DOI 10.1016/j.tips.2006.02.004
   Yegutkin GG, 2008, BBA-MOL CELL RES, V1783, P673, DOI 10.1016/j.bbamcr.2008.01.024
   Yegutkin GG, 2011, EUR J IMMUNOL, V41, P1231, DOI 10.1002/eji.201041292
   Yoshida M, 2001, EXP GERONTOL, V36, P99, DOI 10.1016/S0531-5565(00)00175-3
   Young JS, 2008, J PHYSIOL-LONDON, V586, P5743, DOI 10.1113/jphysiol.2008.162040
   Yuping Wang, 2006, J Tradit Chin Med, V26, P106
   Zhang Y, 2010, CANCER LETT, V293, P189, DOI 10.1016/j.canlet.2010.01.010
NR 116
TC 33
Z9 41
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD JAN
PY 2013
VL 207
IS 1
BP 40
EP 52
DI 10.1111/apha.12012
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 054JX
UT WOS:000312340900006
PM 23176070
DA 2026-01-16
ER

PT J
AU Tao, SY
   Yang, Y
   Tang, J
   Wang, X
   Jiang, NN
   Li, Y
   Wu, P
AF Tao, Siyu
   Yang, Yi
   Tang, Jie
   Wang, Xue
   Jiang, Nannan
   Li, Yuan
   Wu, Ping
TI The efficacy of moxibustion on the pressure pain threshold and substance
   P / leukotriene B4 contents in serum to patients with rheumatoid
   arthritis
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Moxibustion; Rheumatoid arthritis; Pressure pain threshold; Substance P;
   Leukotriene B4; Interleukin-1 beta; Tumor necrosis factor-alpha; Trial
   registration number; ChiCTR-IOR-17012282
ID AMERICAN-COLLEGE; B-4 RECEPTORS; NEUROPEPTIDES; MODULATION; MECHANISMS;
   BLT1; IL-6
AB Objective: To observe the effects of moxibustion on pressure-pain thresholds (PPTs) in affected joints and non-joint areas, as well as the contents of substance P (SP) and leukotriene B4 (LTB4) in serum of patients with rheumatoid arthritis (RA), and to explore the analgesic mechanism of moxibustion in RA patients. Methods: A total of 72 patients with RA were randomly and equally classified into the control and treatment groups. The control group was treated with routine drug therapy, while the treatment group received routine drug therapy and moxibustion. Both groups were treated for 8 weeks. The symptoms, measured by PPTs, Visual analogue scale (VAS), pain joint count (PJC), swollen joint count (SJC) and disease activity score of 28 joints (DAS28), and laboratory indicators, measured by the level of SP, LTB4, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), were compared in the two groups before and after intervention. Results: A total of 66 patients completed the trial, with 1 patients dropping out from the treatment group and 5 patients being excluded and dropped from the control group. Trial endpoints were change (triangle) in symptoms and laboratory indicators. The treatment group showed superior in triangle PPTs of the interphalangeal joints(1301.71 (95 %CI, 967.43-1636.00) vs 443.23(95 %CI, 99.51-786.95)), triangle SP(10.11 (95 %CI, 5.85-14.37) vs 3.10 (95 %CI, -1.13-7.34)), triangle LTB4(13.17 (95 %CI, 7.81-18.54) vs 3.37 (95 %CI, -5.73-12.48)), triangle TNF-alpha(4.57 (95 %CI, 2.60-6.55) vs 0.68 (95 %CI, -1.03-2.40)), triangle IL-1 beta(4.63 (95 %CI, 2.59-6.66) vs 1.63 (95 %CI, -0.53-3.80)), triangle PJC(7.14 (95 %CI, 5.17-8.58) vs 1.84 (95 %CI, 0.66-3.02)), triangle SJC(5.20 (95 %CI, 3.44-6.96) vs 1.00(95 %CI, 0.02-1.98)), triangle VAS(3.6 (95 %CI, 2.99-4.21) vs 0.9 (95 %CI, 0.24-1.57)), and triangle DAS(1.68 (95 %CI, 1.44-1.92) vs 0.41 (95 %CI, 0.08-0.73)) compared to the control group, at weeks 4. Furthermore, there was a significant negative correlation between triangle PPTs of the interphalangeal joints and triangle SP in the treatment group (r < 0, P < 0.05). Conclusion: Moxibustion combined with conventional western medicine can significantly improve PPTs in affected joints of RA patients, alleviate clinical symptoms, and reduce disease activity. The potential mechanism may be related to the down-regulation of SP and LTB4 levels and the reduction of the release of inflammatory factors Il-1 beta and TNF-alpha by moxibustion. The lack of double-blinding is a limitation of our study, which we plan to avoid by establishing a sham moxibustion group in the subsequent trials.
C1 [Tao, Siyu; Yang, Yi; Tang, Jie; Wang, Xue; Jiang, Nannan; Wu, Ping] Chengdu Univ Tradit Chinese Med, Chengdu 610075, Sichuan, Peoples R China.
   [Li, Yuan] Chengdu Univ Tradit Chinese Med, Affiliated Hosp, Chengdu 610075, Sichuan, Peoples R China.
   [Wu, Ping] 1166 Liutai Ave, Chengdu 610075, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Wu, P (corresponding author), Chengdu Univ Tradit Chinese Med, Chengdu 610075, Sichuan, Peoples R China.; Wu, P (corresponding author), 1166 Liutai Ave, Chengdu 610075, Sichuan, Peoples R China.
EM wuping_33@163.com
OI Tao, Siyu/0000-0002-5092-1743
FU National Natural Science Foundation of China [81373738]; Education
   Department of Sichuan Province [2017JY0016, 2022YFS0386]
FX This work was supported by The National Natural Science Foundation of
   China (81373738) and the Education Department of Sichuan Province
   (2017JY0016 and 2022YFS0386) .
CR Aletaha D, 2010, ANN RHEUM DIS, V69, P1580, DOI [10.1136/ard.2010.138461, 10.1002/art.27584]
   Altawil R, 2016, ARTHRIT CARE RES, V68, P1061, DOI 10.1002/acr.22790
   Burrage PS, 2006, FRONT BIOSCI-LANDMRK, V11, P529, DOI 10.2741/1817
   Chen Y, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6436420
   Cortes-Burgos LA, 2009, EUR J PHARMACOL, V617, P59, DOI 10.1016/j.ejphar.2009.06.058
   Douglas SD, 2011, ANN NY ACAD SCI, V1217, P83, DOI 10.1111/j.1749-6632.2010.05826.x
   Barbosa-Cobos RE, 2018, CLIN RHEUMATOL, V37, P901, DOI 10.1007/s10067-017-3929-6
   Fraenkel L, 2021, ARTHRITIS RHEUMATOL, V73, P1108, DOI 10.1002/art.41752
   Gong YY, 2019, PAIN RES MANAG, V2019, DOI 10.1155/2019/4705247
   Graven-Nielsen T, 2010, NAT REV RHEUMATOL, V6, P599, DOI 10.1038/nrrheum.2010.107
   Gursel T, 1997, PROSTAG LEUKOTR ESS, V56, P205, DOI 10.1016/S0952-3278(97)90535-4
   He YS, 2010, Shanghai J Acupunct Moxibustion, V29, P449
   Heisler AC, 2020, ARTHRIT CARE RES, V72, P1122, DOI 10.1002/acr.23994
   Hermans L, 2018, PAIN PRACT, V18, P418, DOI 10.1111/papr.12613
   Hu HF, 2013, Lishizhen Med Mater Med Res, V24, P677
   Karlson EW, 2012, RHEUM DIS CLIN N AM, V38, P405, DOI 10.1016/j.rdc.2012.04.002
   Kubanov AA, 2015, B EXP BIOL MED+, V159, P318, DOI 10.1007/s10517-015-2951-4
   Kuo HP, 2000, AM J RESP CRIT CARE, V162, P1891, DOI 10.1164/ajrccm.162.5.9911065
   Lee YC, 2011, ARTHRITIS RES THER, V13, DOI 10.1186/ar3353
   Leonard AV, 2013, J NEUROTRAUM, V30, P1812, DOI 10.1089/neu.2013.2993
   Li KX, 2020, CLIN EXP RHEUMATOL, V38, P543
   Liao CX, 2023, J PAIN RES, V16, P1739, DOI 10.2147/JPR.S408814
   Lisowska B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139206
   Liu J, 2017, Chin J Tradit Med Sci Technol, V24, P483
   Majumdar R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002336
   Mashaghi A, 2016, CELL MOL LIFE SCI, V73, P4249, DOI 10.1007/s00018-016-2293-z
   Mathis SP, 2010, J IMMUNOL, V185, P3049, DOI 10.4049/jimmunol.1001031
   MITCHELL DM, 1986, ARTHRITIS RHEUM-US, V29, P706, DOI 10.1002/art.1780290602
   O'Connor TM, 2004, J CELL PHYSIOL, V201, P167, DOI 10.1002/jcp.20061
   Oh JE, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.813748
   Okubo M, 2010, GLIA, V58, P599, DOI 10.1002/glia.20948
   PERIANIN A, 1989, BIOCHEM BIOPH RES CO, V161, P520, DOI 10.1016/0006-291X(89)92630-2
   Schratzberger P, 1997, J IMMUNOL, V158, P3895
   SCOTT DL, 1987, LANCET, V1, P1108
   Skovbjerg S, 2017, J PAIN, V18, P274, DOI 10.1016/j.jpain.2016.10.022
   Studenic P, 2012, ARTHRITIS RHEUM-US, V64, P2814, DOI 10.1002/art.34543
   Tao S, 2021, PAIN RES MANAG, V2021, DOI 10.1155/2021/7466313
   Tavano F, 2012, J CROHNS COLITIS, V6, P563, DOI 10.1016/j.crohns.2011.11.004
   Terenzi R, 2013, ANN RHEUM DIS, V72, P1107, DOI 10.1136/annrheumdis-2012-202846
   Tsilioni I, 2016, J PHARMACOL EXP THER, V356, P664, DOI 10.1124/jpet.115.230060
   UDDMAN R, 1986, PAIN, V27, P391, DOI 10.1016/0304-3959(86)90162-4
   Wang NH, 2004, Neural Inj Funct Reconstr, V03, P97
   Wang QQ, 2019, BMC GENOMICS, V20, DOI 10.1186/s12864-019-5510-y
   Wang YN, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/6637554
   Wasserman A, 2018, AM FAM PHYSICIAN, V97, P455
   Wolfe F, 2007, J RHEUMATOL, V34, P1674
   Wu Xiao, 2018, Zhongguo Zhen Jiu, V38, P1189, DOI 10.13703/j.0255-2930.2018.11.014
   Yao J, 2013, WORLD J ACUPUNCT-MOX, V23, P29, DOI 10.1016/S1003-5257(13)60040-9
   Yokomizo T, 2015, J BIOCHEM, V157, P65, DOI 10.1093/jb/mvu078
   Yu ZY, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/7150605
   Zhong YM, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/6108619
   Zhong Yu-Mei, 2020, Zhongguo Zhen Jiu, V40, P976, DOI [10.13703/j.0255-2930.20190729-0002, 10.13703/j.0255-2930.20190729-0002]
NR 52
TC 0
Z9 0
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD SEP
PY 2025
VL 92
AR 103187
DI 10.1016/j.ctim.2025.103187
EA MAY 2025
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 3JL2P
UT WOS:001501799100001
PM 40436210
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Kim, TH
   Kang, JW
AF Kim, Tae-Hun
   Kang, Jung Won
TI Acupuncture for symptoms management in Korean breast cancer survivors: a
   prospective pilot study
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE acupuncture; aromatase inhibitor-related arthralgia; breast cancer
   survivor; hot flushes; insomnia; Korea; post-mastectomy pain; sexual
   dysfunction
ID QUALITY-OF-LIFE; HOT FLASHES; UNMET NEEDS; RELIABILITY; ARTHRALGIA;
   PREVALENCE; VERSION; STATISTICS; VALIDATION; DEPRESSION
AB Background: There is an unmet need for effective treatment of the various treatment-related symptoms experienced by breast cancer survivors. These symptoms could be alleviated by acupuncture. Although several lines of evidence in Western countries suggest that acupuncture has a beneficial effect on symptoms in breast cancer survivors, few relevant studies have been conducted in Korean patients. This pilot study assessed the feasibility of acupuncture for a variety of treatment-related symptoms in Korean breast cancer survivors. Method: From October 2015 to March 2016, we recruited patients who had undergone treatment for breast cancer and subsequently reported symptoms, including aromatase inhibitor-related knee pain, vasomotor symptoms, insomnia, sexual dysfunction and post-mastectomy pain in the chest wall or shoulder. The women received 4 weeks of symptom-specific acupuncture followed by a further 4 weeks of follow-up to evaluate the feasibility of acupuncture for this indication, and its impact on common and symptom-specific outcome variables. Results: Eight study participants were recruited over a period of 6 months, six of whom completed the planned acupuncture treatment and follow-up assessments. A total of 78 acupuncture sessions were performed. We found that acupuncture was feasible, with only six minor self-limiting acupuncture-related adverse events. Most of the women felt that they had benefitted from participation in the study. The preliminary analysis indicated improvement in common symptom-specific outcomes. Conclusion: Our findings suggest that acupuncture is feasible, but low recruitment rates should be considered when considering future acupuncture research in Korean breast cancer survivors. Rigorous evaluation of this symptomatic treatment strategy is now needed in the Korean population.
C1 [Kim, Tae-Hun] Kyung Hee Univ, Korean Med Hosp, Korean Med Clin Trial Ctr, 23 Kyung Hee Dae Ro, Seoul 02447, South Korea.
   [Kang, Jung Won] Kyung Hee Univ, Coll Korean Med, Dept Acupuncture & Moxibust, Seoul, South Korea.
C3 Kyung Hee University; Kyung Hee University
RP Kim, TH (corresponding author), Kyung Hee Univ, Korean Med Hosp, Korean Med Clin Trial Ctr, 23 Kyung Hee Dae Ro, Seoul 02447, South Korea.
EM rockandmineral@gmail.com
FU Kyung Hee University
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This study was
   supported by Kyung Hee University.
CR [Anonymous], 2009, WHO Guidelines on Hand Hygiene in Health Care: First Global Patient Safety Challenge Clean Care is Safer Care, P30
   Aronson JK, 2003, BRIT MED J, V326, P1346, DOI 10.1136/bmj.326.7403.1346
   Bae K, 2015, INTEGR CANCER THER, V14, P496, DOI 10.1177/1534735415596573
   Bae SC, 2001, OSTEOARTHR CARTILAGE, V9, P746, DOI 10.1053/joca.2001.0471
   Bauml J, 2014, ACUPUNCT MED, V32, P183, DOI 10.1136/acupmed-2013-010459
   Blaes AH, 2011, SEMIN ONCOL, V38, P394, DOI 10.1053/j.seminoncol.2011.03.009
   Burg MA, 2015, CANCER-AM CANCER SOC, V121, P623, DOI 10.1002/cncr.28951
   Cheng KKF, 2016, SUPPORT CARE CANCER, V24, P2025, DOI 10.1007/s00520-015-2994-0
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Crew KD, 2007, J CLIN ONCOL, V25, P3877, DOI 10.1200/JCO.2007.10.7573
   Day R, 1999, J CLIN ONCOL, V17, P2659, DOI 10.1200/JCO.1999.17.9.2659
   Derogatis LR, 2015, CURR SEX HEALTH REP, V7, P151, DOI 10.1007/s11930-015-0052-z
   DeSantis CE, 2014, CA-CANCER J CLIN, V64, P252, DOI 10.3322/caac.21235
   Han Changsu, 2004, The World Journal of Men's Health, V22, P68
   Hervik JB, 2016, BREAST CANCER RES TR, V160, P223, DOI 10.1007/s10549-016-4002-x
   Hewitt M., 2005, CANC PATIENT CANC SU
   HWANG JH, 2015, EVID-BASED COMPL ALT, V2015
   Janz NK, 2007, J WOMENS HEALTH, V16, P1348, DOI 10.1089/jwh.2006.0255
   Jeong YJ, 2013, J ALTERN COMPLEM MED, V19, P690, DOI 10.1089/acm.2012.0347
   Jung KW, 2015, CANCER RES TREAT, V47, P127, DOI 10.4143/crt.2015.060
   Kang E, 2012, SUPPORT CARE CANCER, V20, P461, DOI 10.1007/s00520-011-1094-z
   Kim H.Y., 2002, Kor. J. Androl., V20, P50
   Lawani MA, 2017, SYST REV-LONDON, V6, DOI 10.1186/s13643-017-0446-2
   Levine DW, 2003, PSYCHOL ASSESSMENT, V15, P137, DOI 10.1037/1040-3590.15.2.137
   Li XB, 2018, PHARMACOPSYCHIATRY, V51, P100, DOI 10.1055/s-0043-114670
   Lim JW, 2016, J CANCER EDUC, V31, P108, DOI 10.1007/s13187-015-0790-7
   Maass SWMC, 2015, MATURITAS, V82, P100, DOI 10.1016/j.maturitas.2015.04.010
   Mallory MJ, 2015, AM J CHINESE MED, V43, P45, DOI 10.1142/S0192415X15500032
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   McGahuey CA, 2000, J SEX MARITAL THER, V26, P25, DOI 10.1080/009262300278623
   North Amer Menopause Soc, 2013, MENOPAUSE, V20, P888, DOI [10.1097/gme.0b013e3182a122c2, 10.1097/GME.0b013e3182a122c2]
   Paterson C, 1996, BRIT MED J, V312, P1016
   Pereira S, 2015, BREAST, V24, P582, DOI 10.1016/j.breast.2015.05.006
   Sloan JA, 2001, J CLIN ONCOL, V19, P4280, DOI 10.1200/JCO.2001.19.23.4280
   Sohn SI, 2012, SLEEP BREATH, V16, P803, DOI 10.1007/s11325-011-0579-9
   Spilker B, 1991, GUIDE CLIN TRIALS, P198
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   Wang MH, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0355-3
   Yun YH, 2004, ONCOLOGY-BASEL, V66, P439, DOI 10.1159/000079497
   Yun YH, 2004, SUPPORT CARE CANCER, V12, P441, DOI 10.1007/s00520-004-0632-3
NR 40
TC 5
Z9 10
U1 0
U2 19
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD JUN
PY 2019
VL 37
IS 3
BP 164
EP 174
DI 10.1177/0964528419832610
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA IW9LF
UT WOS:000485314300003
PM 30896247
DA 2026-01-16
ER

PT J
AU El Iskandarani, S
   Deng, GRY
AF El Iskandarani, Sarah
   Deng, Gary
TI Acupuncture in hematologic malignancies and hematopoietic cell
   transplantation
SO BLOOD REVIEWS
LA English
DT Review
DE Acupuncture; Cancer symptoms; Lymphoma; Leukemia; Integrative medicine
ID CHEMOTHERAPY-INDUCED NAUSEA; CANCER-RELATED FATIGUE; QUALITY-OF-LIFE;
   PAIN; COMPLEMENTARY; MEDICINE; PATHOPHYSIOLOGY; MANAGEMENT; DIAGNOSIS;
   SURVIVORS
AB Acupuncture is an integrative medicine modality that has been used historically and studied recently for man-aging various symptoms and diseases. Patients with hematological malignancies often experience a high symptom burden including pain, fatigue, nausea, vomiting, and insomnia. Pharmacological interventions are the mainstay of managing these symptoms, although they may not provide adequate control or are not well tolerated due to side effects. There have been many randomized controlled trials of acupuncture on reduction of these symptoms. In this review, we will summarize the current evidence on the effect of acupuncture on the man-agement of common symptoms experienced by patients with hematological malignancies and the current un-derstanding of acupuncture's mechanism of action. The evidence is the strongest for reducing pain and nausea vomiting, less strong for symptoms such as peripheral neuropathy, fatigue, constipation, insomnia, night sweat, and pruritus.
C1 [El Iskandarani, Sarah; Deng, Gary] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, New York, NY 10065 USA.
C3 Memorial Sloan Kettering Cancer Center
RP Deng, GRY (corresponding author), Mem Sloan Kettering Canc Ctr, Integrat Med Serv, New York, NY 10065 USA.
EM dengg@mskcc.org
FU Patient -Centered Outcomes Research Institute (PCORI)
   [CER-2019C1-15392]; NIH/NCI Cancer Center Support Grant [P30 CA008748];
   National Cancer Institute [P30CA008748] Funding Source: NIH RePORTER
FX Supported by the Patient -Centered Outcomes Research Institute (PCORI)
   grant CER-2019C1-15392. This research was funded in part through the
   NIH/NCI Cancer Center Support Grant P30 CA008748.
CR ANDERSSON S, 1995, MED HYPOTHESES, V45, P271, DOI 10.1016/0306-9877(95)90117-5
   Arranz L, 2017, BLOOD REV, V31, P306, DOI 10.1016/j.blre.2017.05.001
   Bao T, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.0681
   Bayo J, 2012, CLIN TRANSL ONCOL, V14, P413, DOI 10.1007/s12094-012-0818-y
   Bell TJ, 2009, PAIN MED, V10, P35, DOI 10.1111/j.1526-4637.2008.00495.x
   Bourin M, 2018, SOJ Pharmacy & Pharmaceutical Sciences, V5, P1, DOI [10.15226/2374-6866/5/3/00185, 10.15226/2374-6866/5/2/00179, DOI 10.15226/2374-6866/5/2/00179, 10.15226/2374-6866/5/4/00189, DOI 10.15226/2374-6866/5/4/00189]
   Brondum L, 2022, SCAND J CARING SCI, V36, P1046, DOI 10.1111/scs.12991
   Bryant AL, 2018, ONCOL NURS FORUM, V45, P653, DOI 10.1188/18.ONF.653-664
   Burger R, 2013, TRANSFUS MED HEMOTH, V40, P336, DOI 10.1159/000354194
   Chien TJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419886662
   Choi TY, 2017, INTEGR CANCER THER, V16, P135, DOI 10.1177/1534735416664172
   Chon TY, 2019, MED ACUPUNCT, V31, P164, DOI 10.1089/acu.2019.1343
   Chung VCH, 2021, BRIT MED BULL, V137, P70, DOI 10.1093/bmb/ldaa046
   Cohen MZ, 2012, J PAIN SYMPTOM MANAG, V44, P168, DOI 10.1016/j.jpainsymman.2011.08.011
   Colvin LA, 2019, PAIN, V160, pS1, DOI 10.1097/j.pain.0000000000001540
   Copelan EA, 2006, NEW ENGL J MED, V354, P1813, DOI 10.1056/NEJMra052638
   DAMICO JF, 1991, FERTIL STERIL, V55, P754
   De Valois B, 2003, FOCUS ALTERNAT COMPL, V8, P134
   Deng G, 2020, PAIN MED, V21, P636, DOI 10.1093/pm/pnz190
   Deng G, 2018, SUPPORT CARE CANCER, V26, P657, DOI 10.1007/s00520-017-3881-7
   Deng GE, 2013, CHEST, V143, pE420, DOI 10.1378/chest.12-2364
   Edlund MJ, 2014, CLIN J PAIN, V30, P557, DOI 10.1097/AJP.0000000000000021
   Evans LS, 2003, LANCET, V362, P139, DOI 10.1016/S0140-6736(03)13868-8
   Ezzo JM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002285.pub2
   Farmer AD, 2018, LANCET GASTROENTEROL, V3, P203, DOI 10.1016/S2468-1253(18)30008-6
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Gertz MA, 2014, BLOOD, V124, P882, DOI 10.1182/blood-2014-03-544759
   GOBBI PG, 1990, CANCER-AM CANCER SOC, V65, P2074, DOI 10.1002/1097-0142(19900501)65:9<2074::AID-CNCR2820650931>3.0.CO;2-O
   GOBBI PG, 1983, CANCER-AM CANCER SOC, V51, P1934, DOI 10.1002/1097-0142(19830515)51:10<1934::AID-CNCR2820511030>3.0.CO;2-R
   Götze H, 2019, J GERIATR ONCOL, V10, P55, DOI 10.1016/j.jgo.2018.05.011
   Goldman N, 2010, NAT NEUROSCI, V13, P883, DOI 10.1038/nn.2562
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Han CH, 2021, CLIN EPIDEMIOL, V13, P907, DOI 10.2147/CLEP.S324193
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   Harris P., 1997, COMPLEMENT THER MED, V5, P156, DOI [10.1016/S0965-2299(97)80059-3, DOI 10.1016/S0965-2299(97)80059-3]
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hesketh PJ, 2017, J CLIN ONCOL, V35, P3240, DOI 10.1200/JCO.2017.74.4789
   Ho RST, 2022, INTEGR MED RES, V11, DOI 10.1016/j.imr.2021.100771
   Ho RST, 2021, ACUPUNCT MED, V39, P3, DOI 10.1177/0964528420920299
   Hogberg K, 2019, SOC HLTH BEHAV, V2, P17
   Holm ACES, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/579321
   Huang CC, 2021, J CLIN MED, V10, DOI 10.3390/jcm10163694
   Huang WJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032960
   Hui KKS, 2010, AUTON NEUROSCI-BASIC, V157, P81, DOI 10.1016/j.autneu.2010.03.022
   Iravani S, 2020, PAIN RES MANAG, V2020, DOI 10.1155/2020/2504674
   Jiang YH, 2010, CHIN J INTEGR MED, V16, P71, DOI 10.1007/s11655-010-0070-7
   Jin YX, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8875433
   Kaptchuk T.J., 2000, WEB HAS NO WEAVER
   Kaptchuk TJ, 2002, ANN INTERN MED, V136, P374, DOI 10.7326/0003-4819-136-5-200203050-00010
   Kumar S S, 2003, Indian J Dermatol Venereol Leprol, V69, P12
   Kurzrock R, 2001, CANCER, V92, P1684, DOI 10.1002/1097-0142(20010915)92:6+<1684::AID-CNCR1497>3.0.CO;2-Z
   Langevin Helene M., 2002, Anatomical Record, V269, P257, DOI 10.1002/ar.10185
   Lee YH, 2020, CLIN EXP DENT RES, V6, P90, DOI 10.1002/cre2.253
   Li DH, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5558590
   Li MX, 2019, COMPLEMENT THER MED, V43, P247, DOI 10.1016/j.ctim.2019.02.013
   Li QW, 2020, CHIN MED-UK, V15, DOI 10.1186/s13020-020-00333-x
   Manchikanti L, 2018, EXPERT REV ANTICANC, V18, P705, DOI 10.1080/14737140.2018.1474103
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   McCrae CS, 2020, J SLEEP RES, V29, DOI 10.1111/jsr.13020
   MDAnderson, 2021, ADULT ANTIEMETIC MAN
   Mesía R, 2019, CURR TREAT OPTION ON, V20, DOI 10.1007/s11864-019-0686-6
   Meyer-Hamme G, 2021, J DIABETES, V13, P469, DOI 10.1111/1753-0407.13130
   Mu JL, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013814
   Muacevic A., 2021, CUREUS J MED SCIENCE, V12
   Navari RM, 2016, NEW ENGL J MED, V374, P1356, DOI 10.1056/NEJMra1515442
   NIH, 2021, DRUGS APPROVED DIFFE
   Niscola P, 2008, BONE MARROW TRANSPL, V41, P757, DOI 10.1038/bmt.2008.3
   Niscola P, 2011, INDIAN J PALLIAT CAR, V17, P175, DOI 10.4103/0973-1075.92333
   Niscola P, 2011, EXPERT REV HEMATOL, V4, P81, DOI [10.1586/ehm.10.79, 10.1586/EHM.10.79]
   Oerlemans S, 2013, HAEMATOLOGICA, V98, P479, DOI 10.3324/haematol.2012.064907
   Ouyang Ba-Si, 2010, Zhongguo Zhen Jiu, V30, P840
   Paley CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub3
   Quasthoff S, 2002, J NEUROL, V249, P9, DOI 10.1007/PL00007853
   Rischer J, 2009, BONE MARROW TRANSPL, V44, P121, DOI 10.1038/bmt.2008.430
   Rosenberg SM, 2013, J THORAC DIS, V5, pS55, DOI 10.3978/j.issn.2072-1439.2013.06.20
   Smith CA, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004046.pub4
   Song GQ, 2019, INFLAMM BOWEL DIS, V25, P1129, DOI 10.1093/ibd/izy371
   Staff NP, 2017, ANN NEUROL, V81, P772, DOI 10.1002/ana.24951
   Stone JAM, 2010, CURR TREAT OPTION ON, V11, P118, DOI 10.1007/s11864-010-0128-y
   Vendrell I, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/984570
   Viera AJ, 2003, AM FAM PHYSICIAN, V67, P1019
   Wang XP, 2018, J CANCER RES THER, V14, pS600, DOI 10.4103/0973-1482.183174
   Wang XS, 2002, J CLIN ONCOL, V20, P1319, DOI 10.1200/JCO.20.5.1319
   Wardley AM., 2020, ACUFOCIN RANDOMIZED
   Yosipovitch G, 2010, DERMATOL THER, V23, P590, DOI 10.1111/j.1529-8019.2010.01366.x
   Yu C, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/208690
   Yu Z, 2020, WORLD J GASTROENTERO, V26, DOI 10.3748/wjg.v26.i23.3182
   Yun Hyeongjun, 2017, Journal of the National Cancer Institute Monographs, P29, DOI [10.1093/jncimonographs/lgx004, 10.1093/jncimonographs/lgx004]
   Yung L, 2003, LANCET, V361, P943, DOI 10.1016/S0140-6736(03)12777-8
   Zhang Y, 2018, SUPPORT CARE CANCER, V26, P415, DOI 10.1007/s00520-017-3955-6
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 91
TC 4
Z9 5
U1 2
U2 14
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0268-960X
EI 1532-1681
J9 BLOOD REV
JI Blood Rev.
PD NOV
PY 2022
VL 56
AR 100985
DI 10.1016/j.blre.2022.100985
EA OCT 2022
PG 10
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA 5U2UP
UT WOS:000876408800004
PM 35725779
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Xia, BJ
   Xie, YP
   Hu, SF
   Xu, TT
   Tong, PJ
AF Xia, Bingjiang
   Xie, Yiping
   Hu, Songfeng
   Xu, Taotao
   Tong, Peijian
TI Effect of Auricular Point Acupressure on Axial Neck Pain After Anterior
   Cervical Discectomy and Fusion: A Randomized Controlled Trial
SO PAIN MEDICINE
LA English
DT Article
DE Auricular Point Acupressure; Axial Neck Pain; Anterior Cervical
   Discectomy and Fusion
ID INTERVERTEBRAL DISC; DISORDERS
AB Objectives. To evaluate the effect of auricular point acupressure (APA) on axial neck pain after anterior cervical discectomy and fusion (ACDF) surgery.
   Design. A prospective randomized controlled trial was performed.
   Subjects and setting. Twenty-nine participants were randomly divided into two groups, real or sham APA. Participants were enrolled from Shaoxing Hospital of Traditional Chinese Medicine, affiliated with Zhejiang Chinese Medical University.
   Methods. Eligible participants received a four-week real or sham APA treatment according to their assigned groups. The clinical outcomes were assessed by the criteria of Hosono et al., the Brief Pain Inventory Short Form (BPI), and the 36-item Short Form Health Survey (SF-36). In addition, plasma interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha were analyzed.
   Results. Patients with severe or moderate axial neck pain accounted for 28.6% and 35.7% in the real APA group at the end of treatment and one-month follow-up. BPI scores were decreased in the real APA group at the end of treatment and one-month follow-up. The total mean score of SF-36 was improved in the real APA group and significantly higher than in the sham APA group. Additional, the levels of IL-1 beta, IL-6, and TNF-alpha were decreased in the real APA group.
   Conclusions. The findings supported the therapeutic effect of APA treatment on axial neck pain after ACDF surgery, and they exert the possible therapeutic effect on downregulating the levels of plasma IL-1 beta, IL-6, and TNF-alpha.
C1 [Xia, Bingjiang; Hu, Songfeng] Zhejiang Chinese Med Univ, Shaoxing Hosp Tradit Chinese Med TCM, Shaoxing, Zhejiang, Peoples R China.
   [Xia, Bingjiang; Xu, Taotao; Tong, Peijian] Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China.
   [Xia, Bingjiang; Hu, Songfeng] Res Dept Spine & Joint Shaoxing, Shaoxing, Zhejiang, Peoples R China.
   [Xie, Yiping] Shangyu Hosp TCM, Shaoxing, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical University
RP Tong, PJ (corresponding author), Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China.
EM zhongxiyijieheguke@163.com
RI Xu, Taotao/GPW-7374-2022; Tong, Peijian/PCS-2009-2025
OI Xu, Taotao/0000-0002-2697-1484; tong, peijian/0000-0003-0948-8674; 
FU State Administration of Tradition Chinese Medicine of Zhejiang province
   [2016ZB132]; Science Technology Bureau of Shaoxing [2015B70060]
FX This study was supported by a grant to Bingjiang Xia from State
   Administration of Tradition Chinese Medicine of Zhejiang province (Grant
   No. 2016ZB132) and Science Technology Bureau of Shaoxing (Grant No.
   2015B70060).
CR Angevine PD, 2003, SPINE, V28, P931, DOI 10.1097/00007632-200305010-00016
   [Anonymous], EVID BASED COMPLEMEN
   [Anonymous], 2000, Qual. Life Res.
   [Anonymous], 2005, Auricular Medicine: A Complete Manual of Auricular Diagnosis and Treatment
   Asher GN, 2010, J ALTERN COMPLEM MED, V16, P1097, DOI 10.1089/acm.2009.0451
   Cao Junming, 2008, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V22, P1200
   Chang H, 2014, J KOREAN NEUROSURG S, V55, P343, DOI 10.3340/jkns.2014.55.6.343
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Fountas KN, 2007, SPINE, V32, P2310, DOI 10.1097/BRS.0b013e318154c57e
   Ganfeng C, 2008, WORLD J INTEGR TRADI, V3, P649
   Hosono N, 2006, EUR SPINE J, V15, P1375, DOI 10.1007/s00586-006-0089-9
   Huang H., 1974, EAR ACUPUNCTURE
   Kawakami M, 1999, J SPINAL DISORD, V12, P50
   Lin WC, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/103570
   [龙厚清 Long Houqing], 2015, [中国矫形外科杂志, Orthopedic Journal of China], V23, P22
   Matsumoto M, 2012, EUR SPINE J, V21, P304, DOI 10.1007/s00586-011-1978-0
   NOGIER PFM, 1972, TREATISE AURICULOTHE
   Oleson T., AURICULOTHERAPY MANU
   Santoro A, 2015, EVID BASED COMPLEMEN, V2015
   [申沧海 Shen Canghai], 2013, [中国修复重建外科杂志, Chinese Journal of Reparative and Reconstructive Surgery], V27, P58
   Slade GD, 2011, PAIN, V152, P2802, DOI 10.1016/j.pain.2011.09.005
   SMITH GW, 1958, J BONE JOINT SURG AM, V40, P607, DOI 10.2106/00004623-195840030-00009
   Wang SQ, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/343608
   World Health Organization, 1990, WHO REG WORK GROUP A
   Xu L, 2015, J NEW CHIN MED, V47, P222
   Yeh CH, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/934670
   Ylinen JJ, 2003, ARCH PHYS MED REHAB, V84, P1043, DOI 10.1016/S0003-9993(03)00039-X
NR 27
TC 18
Z9 20
U1 0
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD JAN
PY 2018
VL 19
IS 1
BP 193
EP 201
DI 10.1093/pm/pnx112
PG 9
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; General & Internal Medicine
GA FT0UG
UT WOS:000422842800021
PM 28505292
OA Bronze
DA 2026-01-16
ER

PT J
AU Li, DX
   Chung, G
   Kim, SK
AF Li, Daxian
   Chung, Geehoon
   Kim, Sun Kwang
TI The Involvement of Central Noradrenergic Pathway in the Analgesic Effect
   of Bee Venom Acupuncture on Vincristine-Induced Peripheral Neuropathy in
   Rats
SO TOXINS
LA English
DT Article
DE chemotherapy-induced peripheral neuropathy; vincristine; bee venom
   acupuncture; spinal wide dynamic range neuron; locus coeruleus;
   adrenergic receptor
ID LOCUS-CERULEUS NEURONS; DORSAL-HORN; SPINAL-CORD; PHOSPHOLIPASE A(2);
   MOUSE MODEL; PAIN MODEL; MECHANISMS; INHIBITION; ELECTROACUPUNCTURE;
   STIMULATION
AB Vincristine is a vinca alkaloid anti-mitotic drug with a broad spectrum of effects on solid and hematologic cancers. The major dose-limiting factor of this anti-cancer regimen is painful peripheral neuropathy. However, no gold-standard analgesic option has been used clinically. In this study, we investigated the effects and mechanism of bee venom acupuncture (BVA) to alleviate peripheral neuropathic pain induced by repeated intraperitoneal infusions of vincristine (1 mg/kg/day, days 1-5 and 8-12) in rats. Subcutaneous injection with bee venom (BV, 1.0 mg/kg) at the ST36 acupoint ameliorated cold and mechanical hypersensitivity (i.e., aberrant withdrawal responses in acetone drop and von Frey hair tests, respectively). In vivo extracellular recording demonstrated that BVA inhibited cutaneous cold (acetone) and mechanical (brush, press, and pinch) stimuli-elicited abnormal hyperexcitation of the spinal wide dynamic range (WDR) neurons in vincristine-treated rats. In addition, the microinjection of lidocaine into the ipsilateral locus coeruleus or the antagonism of the spinal alpha(2)-adrenergic receptors clearly reversed the effects of BVA on cold and mechanical hypersensitivity, indicating a vital role of the descending noradrenergic modulation in analgesia. These findings suggest that BVA could be a potential therapeutic option for vincristine-induced peripheral neuropathy.
C1 [Li, Daxian; Kim, Sun Kwang] Kyung Hee Univ, Grad Sch, Dept Sci Korean Med, Seoul 02447, South Korea.
   [Chung, Geehoon; Kim, Sun Kwang] Kyung Hee Univ, Coll Korean Med, Dept Physiol, Seoul 02447, South Korea.
   [Kim, Sun Kwang] Kyung Hee Univ, Grad Sch, Dept East West Med, Seoul 02447, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University
RP Kim, SK (corresponding author), Kyung Hee Univ, Grad Sch, Dept Sci Korean Med, Seoul 02447, South Korea.; Kim, SK (corresponding author), Kyung Hee Univ, Coll Korean Med, Dept Physiol, Seoul 02447, South Korea.; Kim, SK (corresponding author), Kyung Hee Univ, Grad Sch, Dept East West Med, Seoul 02447, South Korea.
EM lidaxian721@naver.com; geehoon.chung@khu.ac.kr; skkim77@khu.ac.kr
RI ; Chung, Geehoon/AHC-9717-2022; Kim, Sun Kwang/AAM-1289-2020
OI Li, Daxian/0000-0003-1327-5866; Chung, Geehoon/0000-0003-0771-4391; Kim,
   Sun Kwang/0000-0002-2649-6652
FU National Research Foundation of Korea (NRF) - Korean government
   [NRF-2017M3A9E4057926]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (NRF-2017M3A9E4057926).
CR Aufschnaiter A, 2020, TOXINS, V12, DOI 10.3390/toxins12020066
   Baek YH, 2006, BRAIN RES, V1073, P305, DOI 10.1016/j.brainres.2005.12.086
   Baron R, 2006, NAT CLIN PRACT NEURO, V2, P95, DOI 10.1038/ncpneuro0113
   Baron R, 2010, LANCET NEUROL, V9, P807, DOI 10.1016/S1474-4422(10)70143-5
   Boyette-Davis JA, 2018, PAIN MANAG, V8, P363, DOI 10.2217/pmt-2018-0020
   Brightwell JJ, 2009, NEUROSCIENCE, V160, P174, DOI 10.1016/j.neuroscience.2009.02.023
   Cherniack EP, 2018, TOXICON, V154, P74, DOI 10.1016/j.toxicon.2018.09.013
   Choi J, 2017, TOXINS, V9, DOI 10.3390/toxins9110351
   Choi S, 2019, TOXINS, V11, DOI 10.3390/toxins11070396
   Choi S, 2017, J PHYSIOL SCI, V67, P431, DOI 10.1007/s12576-016-0505-9
   CHOI Y, 1994, PAIN, V59, P369, DOI 10.1016/0304-3959(94)90023-X
   Chung ES, 2015, J IMMUNOL, V195, P4853, DOI 10.4049/jimmunol.1500386
   Chung G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09991-8
   CLARK FM, 1991, BRAIN RES, V538, P231, DOI 10.1016/0006-8993(91)90435-X
   De la Calle JL, 2002, BRAIN RES BULL, V59, P245, DOI 10.1016/S0361-9230(02)00866-3
   Dougherty PM, 2007, J PAIN SYMPTOM MANAG, V33, P166, DOI 10.1016/j.jpainsymman.2006.08.006
   EZE O.B. L., 2016, J Pharm Chem Biol Sci, V4, P48
   Flatters SJL, 2004, PAIN, V109, P150, DOI 10.1016/j.pain.2004.01.029
   Gwak YS, 2006, J NEUROTRAUM, V23, P1111, DOI 10.1089/neu.2006.23.1111
   Hickey L, 2014, J NEUROSCI, V34, P4148, DOI 10.1523/JNEUROSCI.4835-13.2014
   Jaggi AS, 2017, N-S ARCH PHARMACOL, V390, P1087, DOI 10.1007/s00210-017-1426-8
   Kerckhove N, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00086
   Kim W, 2016, TOXINS, V8, DOI 10.3390/toxins8020033
   Le Bars D., 2008, The Senses: A Comprehensive Reference, V5, P331, DOI 10.1016/B978-012370880-9.00167-5
   Lee C, 2019, J IMMUNOTHER CANCER, V7, DOI 10.1186/s40425-019-0610-4
   Li DX, 2020, TOXINS, V12, DOI 10.3390/toxins12100620
   Li DX, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071652
   Li D, 2015, TOXINS, V7, P2422, DOI 10.3390/toxins7072422
   Lin TY, 2020, TOXINS, V12, DOI 10.3390/toxins12100618
   Liu SJ, 2008, HEPATOLOGY, V47, P1964, DOI 10.1002/hep.22240
   Llorca-Torralba M, 2016, NEUROSCIENCE, V338, P93, DOI 10.1016/j.neuroscience.2016.05.057
   Lu KW, 2016, SCI REP-UK, V6, DOI 10.1038/srep22123
   Ma WY, 2003, BRAIN RES, V970, P110, DOI 10.1016/S0006-8993(03)02293-5
   Millan MJ, 2002, PROG NEUROBIOL, V66, P355, DOI 10.1016/S0301-0082(02)00009-6
   Moon DO, 2006, INT IMMUNOPHARMACOL, V6, P1796, DOI 10.1016/j.intimp.2006.07.027
   Mora E, 2016, AM J CANCER RES, V6, P2416
   Muto Y, 2012, BRIT J PHARMACOL, V166, P1047, DOI 10.1111/j.1476-5381.2011.01820.x
   Nazemi S, 2015, CLIN EXP PHARMACOL P, V42, P772, DOI 10.1111/1440-1681.12414
   Patel R, 2019, EUR J PAIN, V23, P183, DOI 10.1002/ejp.1300
   Paxinos G, 1998, RAT BRAIN IN STEREOTAXIC COORDINATES, FOURTH ED., pix
   Pertovaara A, 2006, HAND CLINIC, V81, P179, DOI 10.1016/S0072-9752(06)80017-5
   REN K, 1990, J NEUROPHYSIOL, V64, P1098, DOI 10.1152/jn.1990.64.4.1098
   Renn CL, 2011, MOL PAIN, V7, DOI 10.1186/1744-8069-7-29
   Roh DH, 2004, J PAIN, V5, P297, DOI 10.1016/j.jpain.2004.05.003
   Safari MS, 2009, PHARMACOL BIOCHEM BE, V92, P629, DOI 10.1016/j.pbb.2009.03.002
   Seo BK, 2017, TOXINS, V9, DOI 10.3390/toxins9110361
   Soliman C, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0224028
   Song Z, 2013, NEUROSCIENCE, V253, P426, DOI 10.1016/j.neuroscience.2013.09.006
   Starobova H, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00174
   Viisanen H, 2007, NEUROSCIENCE, V146, P1785, DOI 10.1016/j.neuroscience.2007.03.016
   Weng HR, 2003, PAIN, V103, P131, DOI 10.1016/S0304-3959(02)00445-1
   Yin CS, 2008, RES VET SCI, V84, P159, DOI 10.1016/j.rvsc.2007.04.004
   Yoshimura M, 2006, J PHARMACOL SCI, V101, P107, DOI 10.1254/jphs.CRJ06008X
   You HJ, 2003, BRAIN RES, V960, P235, DOI 10.1016/S0006-8993(02)03895-7
   Yu LL, 2019, J PAIN RES, V12, P231, DOI 10.2147/JPR.S182876
   Zajaczkowska R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061451
   Zeng YJ, 2018, LASER MED SCI, V33, P295, DOI 10.1007/s10103-017-2367-7
   Zhang S, 2018, TOXICON, V148, P64, DOI 10.1016/j.toxicon.2018.04.012
   Zhang S, 2018, J PAIN RES, V11, P505, DOI 10.2147/JPR.S152550
   Zheng FY, 2011, NEUROSCIENCE, V176, P447, DOI 10.1016/j.neuroscience.2010.12.052
   ZIMMERMANN M, 1983, PAIN, V16, P109, DOI 10.1016/0304-3959(83)90201-4
   Zuo CY, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/1807287
NR 62
TC 22
Z9 23
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6651
J9 TOXINS
JI Toxins
PD DEC
PY 2020
VL 12
IS 12
AR 775
DI 10.3390/toxins12120775
PG 16
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA PK5WY
UT WOS:000602516100001
PM 33291335
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, Q
   Li, ZH
   Nie, DY
   Mu, XR
   Wang, YX
   Jiang, YW
   Zhang, YC
   Lu, ZG
AF Wang, Qian
   Li, Zhonghao
   Nie, Dengyun
   Mu, Xinru
   Wang, Yuxuan
   Jiang, Yongwei
   Zhang, Yongchen
   Lu, Zhigang
TI Low-frequency electroacupuncture exerts antinociceptive effects through
   activation of POMC neural circuit induced endorphinergic input to the
   periaqueductal gray from the arcuate nucleus
SO MOLECULAR PAIN
LA English
DT Article
DE Electroacupuncture; beta-endorphin; pain; antinociceptive; mechanism
ID CANCER PAIN; ACUPUNCTURE; RECEPTORS
AB It has been widely recognized that electroacupuncture (EA) inducing the release of beta-endorphin represents a crucial mechanism of EA analgesia. The arcuate nucleus (ARC) in the hypothalamus is a vital component of the endogenous opioid peptide system. Serving as an integration center, the periaqueductal gray (PAG) receives neural fiber projections from the frontal cortex, insular cortex, and ARC. However, the specific mechanisms how EA facilitates the release of beta-endorphin within the ARC, eliciting analgesic effects are yet to be elucidated. In this study, we conducted in vivo and in vitro experiments by transcriptomics, microdialysis, photogenetics, chemical genetics, and calcium imaging, combined with transgenic animals. Firstly, we detected 2 Hz EA at the Zusanli (ST36) increased the level of beta-endorphin and transcriptional level of proopiomelanocortin (POMC). Our transcriptomics profiling demonstrated that 2 Hz EA at the ST36 modulates the expression of c-Fos and Jun B in ARC brain nuclear cluster, and the transcriptional regulation of 2 Hz EA mainly occur in POMC neurons by Immunofluorescence staining verification. Meaning while, 2 Hz EA specifically activated the cAMP-PKA-CREB signaling pathway in ARC which mediating the c-Fos and Jun B transcription, and 2 Hz EA analgesia is dependent on the activation of cAMP-PKA-CREB signaling pathway in ARC. In order to investigate how the beta-endorphin produced in ARC transfer to integration center PAG, transneuronal tracing technology was used to observe the 2 Hz EA promoted the neural projection from ARC to PAG compared to 100 Hz EA and sham mice. Inhibited PAGGABA neurons, the transfer of beta-endorphin from the ARC nucleus to the PAG nucleus through the ARCPOMC-PAGGABA neural circuit. Furthermore, by manipulating the excitability of POMC neurons from ARCPOMC to PAGGABA using inhibitory chemogenetics and optogenetics, we found that this inhibition significantly reduced transfer of beta-endorphin from the ARC nucleus to the PAG nucleus and the effectiveness of 2 Hz EA analgesia in neurological POMC cyclization recombination enzyme (Cre) mice and C57BL/6J mice, which indicates that the transfer of beta-endorphin depends on the activation of POMC neurons prefect from ARCPOMC to PAGGABA. These findings contribute to our understanding of the neural circuitry underlying the EA pain-relieving effects and maybe provide valuable insights for optimizing EA stimulation parameters in clinical pain treatment using the in vivo dynamic visual investigating the central analgesic mechanism.
C1 [Wang, Qian; Zhang, Yongchen] Shandong Univ Tradit Chinese Med, 4655 Daxue Rd, Nanjing 250355, Shandong, Peoples R China.
   [Li, Zhonghao] Peking Univ, Natl Inst Drug Dependence, Beijing, Peoples R China.
   [Li, Zhonghao] Peking Univ, Beijing Key Lab Drug Dependence Res, Beijing, Peoples R China.
   [Li, Zhonghao] Peking Univ Hlth Sci Ctr, Sch Basic Med Sci, Beijing, Peoples R China.
   [Li, Zhonghao; Nie, Dengyun; Mu, Xinru; Wang, Yuxuan; Jiang, Yongwei; Lu, Zhigang] Nanjing Univ Chinese Med, Key Lab Acupuncture & Med Res, Minist Educ, 138 Xianlin Rd, Nanjing 210046, Peoples R China.
   [Li, Zhonghao; Nie, Dengyun; Mu, Xinru; Wang, Yuxuan; Lu, Zhigang] Nanjing Univ Chinese Med, Sch Integrat Med, Nanjing, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Peking University;
   Peking University; Nanjing University of Chinese Medicine; Nanjing
   University of Chinese Medicine
RP Zhang, YC (corresponding author), Shandong Univ Tradit Chinese Med, 4655 Daxue Rd, Nanjing 250355, Shandong, Peoples R China.; Lu, ZG (corresponding author), Nanjing Univ Chinese Med, Key Lab Acupuncture & Med Res, Minist Educ, 138 Xianlin Rd, Nanjing 210046, Peoples R China.
EM zhangyc58@sina.com; luzg@njucm.edu.cn
RI ; Nie, Dengyun/JPL-9654-2023
OI lu, zhigang/0000-0001-6769-3647; 
FU National Natural Science Foundation of China
FX No Statement Available
CR Aklan I, 2020, CELL METAB, V31, P313, DOI 10.1016/j.cmet.2019.11.016
   Beale CN, 2018, J AM ASSOC LAB ANIM, V57, P392, DOI [10.30802/AALAS-JAALAS-17-000077, 10.30802/aalas-jaalas-17-000077]
   Chai WX, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/2598975
   Chang S, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aax1342
   Charlson ME, 2022, PSYCHOTHER PSYCHOSOM, V91, P8, DOI 10.1159/000521288
   Cuitavi J, 2021, TRENDS BIOCHEM SCI, V46, P315, DOI 10.1016/j.tibs.2020.10.002
   del Rey A, 2012, ANN NY ACAD SCI, V1262, P101, DOI 10.1111/j.1749-6632.2012.06621.x
   Dimidschstein J, 2016, NAT NEUROSCI, V19, P1743, DOI 10.1038/nn.4430
   Emons B, 2023, ANN GEN PSYCHIATR, V22, DOI 10.1186/s12991-023-00437-2
   Gao F, 2018, BRAIN BEHAV IMMUN, V67, P91, DOI 10.1016/j.bbi.2017.08.004
   Grüne B, 2021, UROLITHIASIS, V49, P269, DOI 10.1007/s00240-020-01234-2
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   Han P, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129576
   Harno E, 2018, PHYSIOL REV, V98, P2381, DOI 10.1152/physrev.00024.2017
   Hossain I, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00500
   Hu ML, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/3840202
   Labeur M, 2009, REV ENDOCR METAB DIS, V10, P103, DOI 10.1007/s11154-008-9080-6
   Lai F, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/3620741
   Lau BK, 2014, CURR OPIN NEUROBIOL, V29, P159, DOI 10.1016/j.conb.2014.07.010
   Lee HJ, 2009, ACUPUNCTURE ELECTRO, V34, P27, DOI 10.3727/036012909803861095
   Li HP, 2019, J PAIN RES, V12, P1259, DOI 10.2147/JPR.S191900
   Li QY, 2023, INTEGR CANCER THER, V22, DOI 10.1177/15347354231192017
   Liang Q, 2020, AM J CHINESE MED, V48, P1769, DOI 10.1142/S0192415X20500883
   Lv ZT, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1899-6
   Musolino ST, 2019, J NEUROSCI METH, V313, P24, DOI 10.1016/j.jneumeth.2018.12.013
   Nimbalkar S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25198-x
   Oh JE, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.813748
   Samineni VK, 2017, ENEURO, V4, DOI 10.1523/ENEURO.0129-16.2017
   Sanna MD, 2014, NEUROPHARMACOLOGY, V86, P67, DOI 10.1016/j.neuropharm.2014.06.007
   Shao XM, 2016, NEURAL PLAST, V2016, DOI 10.1155/2016/5320641
   Shapouri-Moghaddam A, 2018, J CELL PHYSIOL, V233, P6425, DOI 10.1002/jcp.26429
   Song HF, 2016, PLOS COMPUT BIOL, V12, DOI 10.1371/journal.pcbi.1004792
   Su XY, 2019, NEURON, V102, P858, DOI 10.1016/j.neuron.2019.03.030
   Torres SF, 2019, TRIALS, V20, DOI 10.1186/s13063-019-3813-6
   Ueki R, 2012, J AM CHEM SOC, V134, P12398, DOI 10.1021/ja305051u
   Walker CCF, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11081461
   Wang JY, 2020, J PAIN RES, V13, P1629, DOI 10.2147/JPR.S242330
   WANG Q, 1990, BRAIN RES, V518, P40, DOI 10.1016/0006-8993(90)90951-7
   Wiech K, 2016, SCIENCE, V354, P584, DOI 10.1126/science.aaf8934
   Williams JT, 2013, PHARMACOL REV, V65, P223, DOI 10.1124/pr.112.005942
   Zhang XY, 2020, ELIFE, V9, DOI 10.7554/eLife.55289
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zhou XX, 2022, EUR J PAIN, V26, P991, DOI 10.1002/ejp.1923
NR 43
TC 9
Z9 10
U1 2
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
EI 1744-8069
J9 MOL PAIN
JI Mol. Pain
PD MAY
PY 2024
VL 20
AR 17448069241254201
DI 10.1177/17448069241254201
PG 22
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA RD2V8
UT WOS:001225676800001
PM 38670551
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Noble, S
   Williamson, IJ
   Brewster, AE
   Ionescu, AA
   Kulatilake, N
AF Noble, S.
   Williamson, I. J.
   Brewster, A. E.
   Ionescu, A. A.
   Kulatilake, N.
TI The role of acupuncture in the management of post-thoracotomy pain:
   description and evaluation of an acupuncture service in lung cancer
   survivorship
SO LUNG CANCER
LA English
DT Meeting Abstract
C1 [Noble, S.] Cardiff Univ, Cardiff CF10 3AX, S Glam, Wales.
   [Williamson, I. J.; Ionescu, A. A.] Royal Gwent Hosp, Newport, Gwent, Wales.
   [Brewster, A. E.] Velindre Hosp, Cardiff, S Glam, Wales.
   [Kulatilake, N.] Univ Hosp Wales, Cardiff, S Glam, Wales.
C3 Cardiff University; Royal Gwent Hospital; Velindre Cancer Centre;
   Cardiff University
NR 0
TC 1
Z9 2
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0169-5002
J9 LUNG CANCER
JI Lung Cancer
PD JAN
PY 2013
VL 79
SU 1
MA 114
BP S39
EP S40
DI 10.1016/S0169-5002(13)70114-4
PG 2
WC Oncology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Respiratory System
GA 094BW
UT WOS:000315239000115
DA 2026-01-16
ER

PT J
AU Donald, GK
   Tobin, I
   Stringer, J
AF Donald, Graeme K.
   Tobin, Irene
   Stringer, Jacqui
TI Evaluation of acupuncture in the management of chemotherapy-induced
   peripheral neuropathy
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL;
   DIABETIC-NEUROPATHY; DOUBLE-BLIND; PAIN; AMITRIPTYLINE; PREGABALIN;
   EFFICACY
AB Aim To clinically evaluate the effectiveness of acupuncture when used in the management of chemotherapy-induced peripheral neuropathy (PN).
   Background During cancer treatment, certain chemotherapies can cause varying degrees of PN. Patients' quality of life can be seriously impaired through loss of sensation, pain or mobility problems. Conventional medications routinely used to manage neuropathic symptoms have poor side-effect profiles and there is little or no evidence justifying their use to treat chemotherapy-related neurotoxicities. There are studies suggesting that acupuncture may be an effective therapy in treating PN across a number of different aetiologies.
   Design A retrospective service evaluation.
   Method Patients (n=18) were referred for acupuncture by the medical staff and/or nurse specialists or they self-referred for treatment. A course of six weekly acupuncture sessions was offered to them, and their details were recorded on an evaluation form prior to session one. Points were selected by acupuncturists, based on patient presentation, and needles remained in situ for 30-45 min. Treatments took place in outpatient clinics, chemotherapy day case ward or a drop-in clinic based in a physiotherapy gym. The evaluation form was completed at the end of session 6 by a therapist who had not been involved in patient care.
   Results 82% (n=14) of patients reported an improvement in symptoms following their course of acupuncture; one patient with advanced disease died during the 6 weeks. Some patients derived additional benefits from the treatment including a reduction in analgesic use and improved sleeping patterns. The most common acupoints used were SP6 (n=18), ST36 (n=18) and LV3 (n=14).
   Conclusion Although these results are encouraging, they are uncontrolled. They suggest that acupuncture could be an option for these patients and controlled trials using validated patient-reported outcome measures are justified.
C1 [Donald, Graeme K.; Tobin, Irene; Stringer, Jacqui] Christie NHS Fdn Trust, Complementary Therapy Serv, Manchester M20 4BX, Lancs, England.
C3 Christie NHS Foundation Trust
RP Donald, GK (corresponding author), Christie NHS Fdn Trust, Complementary Therapy Serv, Wilmslow Rd, Manchester M20 4BX, Lancs, England.
EM graeme.donald@christie.nhs.uk
RI Donald, Graeme/O-1320-2015
OI Donald, Graeme/0000-0002-5405-9222
CR Abuaisha BB, 1998, DIABETES RES CLIN PR, V39, P115, DOI 10.1016/S0168-8227(97)00123-X
   Arezzo JC, 2008, BMC NEUROL, V8, DOI 10.1186/1471-2377-8-33
   Collins SL, 2000, J PAIN SYMPTOM MANAG, V20, P449, DOI 10.1016/S0885-3924(00)00218-9
   Dworkin RH, 2007, PAIN, V132, P237, DOI 10.1016/j.pain.2007.08.033
   Goldman N, 2010, NAT NEUROSCI, V13, P883, DOI 10.1038/nn.2562
   Hui KKS, 2005, NEUROIMAGE, V27, P479, DOI 10.1016/j.neuroimage.2005.04.037
   Kaptchuk TJ, 1999, JAMA-J AM MED ASSOC, V281, P1270, DOI 10.1001/jama.281.14.1270
   Kautio AL, 2008, J PAIN SYMPTOM MANAG, V35, P31, DOI 10.1016/j.jpainsymman.2007.02.043
   Manni L, 2010, AUTON NEUROSCI-BASIC, V157, P9, DOI 10.1016/j.autneu.2010.03.020
   Napadow V, 2009, NEUROIMAGE, V47, P289, DOI 10.1016/j.neuroimage.2009.03.060
   Postma TJ, 2000, ANN ONCOL, V11, P509, DOI 10.1023/A:1008345613594
   Rao RD, 2007, CANCER-AM CANCER SOC, V110, P2110, DOI 10.1002/cncr.23008
   Rosenstock J, 2004, PAIN, V110, P628, DOI 10.1016/j.pain.2004.05.001
   Saif M Wasif, 2005, Ther Clin Risk Manag, V1, P249
   Shlay JC, 1998, JAMA-J AM MED ASSOC, V280, P1590, DOI 10.1001/jama.280.18.1590
   Tong YQ, 2010, J ACUPUNCT MERIDIAN, V3, P95, DOI 10.1016/S2005-2901(10)60018-0
   Vondracek P, 2009, EUR J PAEDIATR NEURO, V13, P332, DOI 10.1016/j.ejpn.2008.06.011
   Watson CPN, 2003, PAIN, V105, P71, DOI 10.1016/S0304-3959(03)00160-X
   Wilkes Gail, 2007, Semin Oncol Nurs, V23, P162, DOI 10.1016/j.soncn.2007.05.001
   Wong Raimond, 2006, Acupunct Med, V24, P87
   Zhang C, 2010, J TRADIT CHIN MED, V30, P13, DOI 10.1016/S0254-6272(10)60003-9
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zhou YH, 2009, AM J CLIN ONCOL-CANC, V32, P319, DOI 10.1097/COC.0b013e318173a520
NR 23
TC 70
Z9 82
U1 2
U2 32
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-5284
J9 ACUPUNCT MED
JI Acupunct. Med.
PD SEP
PY 2011
VL 29
IS 3
BP 230
EP 233
DI 10.1136/acupmed.2011.010025
PG 4
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 812XL
UT WOS:000294326700013
PM 21875929
DA 2026-01-16
ER

PT J
AU Oura, M
   Omata, F
   Nishikawa, Y
AF Oura, Mitsuaki
   Omata, Fumiya
   Nishikawa, Yoshitaka
TI Acupuncture for Cancer Survivors
SO JAMA ONCOLOGY
LA English
DT Letter
ID PAIN
C1 [Oura, Mitsuaki] Takeda Gen Hosp, Fukushima 9650876, Japan.
   [Omata, Fumiya] Hirata Cent Hosp, Dept Internal Med, Fukushima, Japan.
   [Nishikawa, Yoshitaka] Kyoto Univ, Sch Publ Hlth, Kyoto, Japan.
C3 Kyoto University
RP Oura, M (corresponding author), Takeda Gen Hosp, Fukushima 9650876, Japan.
EM mooura-tky@umin.ac.jp
RI ; Nishikawa, Yoshitaka/GLV-3579-2022
OI Oguro, Fumiya/0000-0003-4739-7589; Oura, Mitsuaki/0000-0002-4907-4647;
   Nishikawa, Yoshitaka/0000-0003-3313-1990
CR Bankhead C., 2017, Catalogue of bias
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Mao JJ, 2021, JAMA ONCOL, V7, P720, DOI 10.1001/jamaoncol.2021.0310
   Robinson-Papp J, 2015, J PAIN SYMPTOM MANAG, V50, P381, DOI 10.1016/j.jpainsymman.2015.03.013
   Zeliadt SB, 2020, MED CARE, V58, pS101, DOI 10.1097/MLR.0000000000001368
NR 5
TC 1
Z9 2
U1 0
U2 10
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2374-2437
EI 2374-2445
J9 JAMA ONCOL
JI JAMA Oncol.
PD SEP
PY 2021
VL 7
IS 9
BP 1399
EP 1400
DI 10.1001/jamaoncol.2021.2517
EA JUL 2021
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA UR2VP
UT WOS:000679478800001
PM 34323934
DA 2026-01-16
ER

PT J
AU Ke, MY
   Qian, JJ
   Hao, F
   Li, XY
   Wu, HJ
   Luo, X
   Xu, B
   Gu, CY
   Yang, Y
AF Ke, Mengying
   Qian, Jinjun
   Hao, Feng
   Li, Xinying
   Wu, Hongjie
   Luo, Xian
   Xu, Bin
   Gu, Chunyan
   Yang, Ye
TI Acupuncture Synergized With Bortezomib Improves Survival of Multiple
   Myeloma Mice via Decreasing Metabolic Ornithine
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE ornithine; metabolomics; multiple myeloma; acupuncture; ODC1
ID INDUCED PERIPHERAL NEUROPATHY; THERAPEUTIC TARGETS; BREAST-CANCER; PAIN;
   ELECTROACUPUNCTURE; PROLIFERATION
AB Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients are fraught with high recurrence rate and incurability. Acupuncture is known for alleviating patient symptoms and improving the quality of life, but it is not well investigated in MM, especially in combination with bortezomib. In this study, we employed LC-MS and UHPLC-MS together with bioinformatics methods to test serum samples from 5TMM3VT MM murine model mice with four different treatments [control (C) group, bortezomib (V) treatment group, acupuncture (A) group, and combined (VA) group]. MM mice in group VA had longer survival time than mice in group A or group V. Joint pathway analysis indicated the underlying arginine and proline metabolism pathway among the 32 significantly decreased metabolites in group VA. CCK-8 assay and in vivo experiments validated that ornithine, the metabolite of arginine, promoted MM cell proliferation. In addition, gene expression omnibus (GEO) database analysis suggested that MM patients with higher ornithine decarboxylase 1 (ODC1) expression were evidently associated with poor overall survival. In summary, this study demonstrates the synergistic effects of acupuncture and bortezomib on extending the survival of MM model mice and provides potential therapeutic targets in the treatment of MM.
C1 [Ke, Mengying; Gu, Chunyan] Nanjing Univ Chinese Med, Large Data Ctr, Nanjing Hosp Chinese Med, Nanjing, Peoples R China.
   [Ke, Mengying; Qian, Jinjun; Li, Xinying; Wu, Hongjie; Luo, Xian; Gu, Chunyan; Yang, Ye] Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, Nanjing, Peoples R China.
   [Hao, Feng; Xu, Bin] Nanjing Univ Chinese Med, Acupuncture & Tuina Coll, Nanjing, Peoples R China.
   [Xu, Bin] Nanjing Univ Chinese Med, Key Lab Acupuncture & Med Res, Minist Educ, Nanjing, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine; Nanjing University of
   Chinese Medicine
RP Gu, CY (corresponding author), Nanjing Univ Chinese Med, Large Data Ctr, Nanjing Hosp Chinese Med, Nanjing, Peoples R China.; Gu, CY; Yang, Y (corresponding author), Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, Nanjing, Peoples R China.; Xu, B (corresponding author), Nanjing Univ Chinese Med, Acupuncture & Tuina Coll, Nanjing, Peoples R China.; Xu, B (corresponding author), Nanjing Univ Chinese Med, Key Lab Acupuncture & Med Res, Minist Educ, Nanjing, Peoples R China.
EM xubin@njucm.edu.cn; guchunyan@njucm.edu.cn; yangye876@sina.com
RI Hao, Feng/E-1001-2016; Wu, Hongjie/OOL-1666-2025; YANG, YE/B-8740-2014
OI YANG, YE/0000-0003-0228-5102
CR Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Bednarz-Misa I, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11081086
   Bianchi-Smiraglia A, 2018, J CLIN INVEST, V128, P4682, DOI 10.1172/JCI70712
   Blimark CH, 2018, HAEMATOLOGICA, V103, P506, DOI 10.3324/haematol.2017.178103
   Chao LF, 2009, BREAST CANCER RES TR, V118, P255, DOI 10.1007/s10549-009-0533-8
   Chen Y, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.736373
   Chen Y, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.00767
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Chong J, 2018, NUCLEIC ACIDS RES, V46, pW486, DOI 10.1093/nar/gky310
   Colombero C, 2020, BIOCHIMIE, V171, P147, DOI 10.1016/j.biochi.2020.02.014
   Dou RJ, 2021, CELL DEATH DIS, V12, DOI 10.1038/s41419-021-03510-4
   Du T, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.658861
   Faubert B, 2020, SCIENCE, V368, P152, DOI 10.1126/science.aaw5473
   Fernandez-Garcia JC, 2019, J CLIN MED, V8, DOI 10.3390/jcm8010071
   Gamble LD, 2021, CANCERS, V13, DOI 10.3390/cancers13081807
   Gamble LD, 2019, SCI TRANSL MED, V11, DOI 10.1126/scitranslmed.aau1099
   Gan CF, 2020, J STEROID BIOCHEM, V202, DOI 10.1016/j.jsbmb.2020.105709
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Grzywa TM, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00938
   Gu CY, 2021, MOL CANCER, V20, DOI 10.1186/s12943-021-01380-0
   Gu CY, 2021, LEUKEMIA, V35, P1803, DOI 10.1038/s41375-020-01033-z
   Guo MJ, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.675939
   Guo T, 2019, CANCER MED-US, V8, P7754, DOI 10.1002/cam4.2637
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   He W, 2017, NPJ PRECIS ONCOL, V1, DOI 10.1038/s41698-017-0014-1
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hou JH, 2020, ONCOTARGETS THER, V13, P959, DOI 10.2147/OTT.S235944
   Joshua DE, 2019, MED J AUSTRALIA, V210, P375, DOI 10.5694/mja2.50129
   Ke MY, 2021, J HEMATOL ONCOL, V14, DOI 10.1186/s13045-021-01101-6
   Khan A, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-20896-z
   Kourelis TV, 2013, J CLIN ONCOL, V31, P4319, DOI 10.1200/JCO.2013.50.8499
   Kus K, 2018, BREAST CANCER RES, V20, DOI 10.1186/s13058-018-1075-y
   Kyle RA, 2003, BRIT J HAEMATOL, V121, P749
   Lee YC, 2018, INT J MED SCI, V15, P953, DOI 10.7150/ijms.24146
   Lemos H, 2019, NAT REV CANCER, V19, P162, DOI 10.1038/s41568-019-0106-z
   Li Z, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122550
   Liberti MV, 2016, TRENDS BIOCHEM SCI, V41, P287, DOI 10.1016/j.tibs.2016.01.004
   Lim HD, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151882
   Lin JG, 2002, PAIN, V99, P509, DOI 10.1016/S0304-3959(02)00261-0
   Lin Y, 2019, INT J CANCER, V145, P1679, DOI 10.1002/ijc.32190
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Mavrommatis CI, 2012, PAIN, V153, P1720, DOI 10.1016/j.pain.2012.05.005
   Mi WL, 2008, BRAIN RES BULL, V77, P98, DOI 10.1016/j.brainresbull.2008.04.008
   Minnie SA, 2020, J CLIN INVEST, V130, P1565, DOI 10.1172/JCI129205
   Miret JJ, 2019, J IMMUNOTHER CANCER, V7, DOI 10.1186/s40425-019-0504-5
   O'Regan D, 2010, AUTON NEUROSCI-BASIC, V157, P96, DOI 10.1016/j.autneu.2010.05.001
   Poillet-Perez L, 2018, NATURE, V563, P569, DOI 10.1038/s41586-018-0697-7
   Qiao L, 2020, AM J CHINESE MED, V48, P245, DOI 10.1142/S0192415X20500135
   Robinson AJ, 2020, CANCER RES, V80, P937, DOI 10.1158/0008-5472.CAN-19-1920
   Seo SY, 2017, AM J CHINESE MED, V45, P1573, DOI 10.1142/S0192415X17500859
   Song X, 2019, CANCER RES, V79, P5288, DOI 10.1158/0008-5472.CAN-19-1504
   Steggerda SM, 2017, J IMMUNOTHER CANCER, V5, DOI 10.1186/s40425-017-0308-4
   Swarm RA, 2019, J NATL COMPR CANC NE, V17, P977, DOI 10.6004/jnccn.2019.0038
   Wang CH, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419866919
   Yan Wusheng, 2012, BMC Res Notes, V5, P73, DOI 10.1186/1756-0500-5-73
   Yao WF, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17091514
   Ye Z, 2019, ONCOTARGETS THER, V12, P4081, DOI 10.2147/OTT.S198341
   Zhang C, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.00681
   Zhao HY, 2021, BIOMED PHARMACOTHER, V142, DOI 10.1016/j.biopha.2021.112045
   Zou Y, 2021, J INFLAMM RES, V14, P3501, DOI 10.2147/JIR.S312385
NR 61
TC 4
Z9 5
U1 5
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD NOV 2
PY 2021
VL 11
AR 779562
DI 10.3389/fonc.2021.779562
PG 14
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA WZ0BH
UT WOS:000719639500001
PM 34804983
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ruiz-López, D
   Alonso-Babarro, A
AF Ruiz-Lopez, Diego
   Alonso-Babarro, Alberto
TI Questionnaire made to understand the opioid analgesics prescription
   habits in the community of Madrid (Spain)
SO ATENCION PRIMARIA
LA Spanish
DT Article
DE Pain; Primary Care; Palliative Care; Opioids
ID CHRONIC NONCANCER PAIN; PALLIATIVE-CARE; ABUSE; TRENDS; MANAGEMENT;
   ADDICTION; MORTALITY; PATTERNS; MISUSE; RISK
AB Objective: Pain is the fearest and disabling symptom for cancer patients. The cornerstone of treatment is opioid analgesics. The objective of this research was to relate the opioid consumption existing in the Community of Madrid (CM) with the prescription habits expressed by the Primary Care (PrC) and Palliative Care (PalC) physicians.
   Design: An opioid prescription habits questionnaire was designed. Sampling was consecutive non-probability.
   Site: PrC and specific PalC resources in the CM.
   Participants: The study population included all the family doctors who worked in PrC in the Madrid Public Health Service and all the physicians who worked in some specific PalC resources, both home-based teams and supportive hospital teams in the CM of the public and private/concerted health network services.
   Main measurements: We asked about the strong and weak opioids most used in moderate-severe oncological and non-oncological pain, the preferred administration route, the safety in the use of opioids in the treatment of pain and the preferred clinical practice guidelines.
   Results: The questionnaire was answered by 840 PrC physicians (20%) and 56 PaIC physicians (45%). For the treatment of moderate-severe cancer pain in both groups of professionals, the first choice was morphine; however, in non-cancer pain for PrC it was fentanyl and morphine for PalC professionals. Regarding the route of administration, 70% of family doctors and 87% of PalC physicians stated that the oral route was the first choice, compared to 27% in PrC and 5% in PalC who preferred the transdermal route. The PrC physicians rated their ability to use opioids as average (4-7/10), while the palliativists considered it as high (8-10/10). In PrC, they declared that they knew, above all, the European Association for Palliative Care (EAPC) and National Institute for Health and Care Excellence (NICE) guidelines, although the largest number answered that they trusted their experience. PaIC physicians preferred to use the EAPC guide.
   Conclusions: There is a clear disagreement between the actual consumption of opioids and the prescribing habits manifested by family doctors, as well as a false certainty in prescribing these drugs. (C) 2021 Published by Elsevier Espana, S.L.U.
C1 [Ruiz-Lopez, Diego] Ctr Salud Legazpi, Equipo Soporte Paliat Domiciliario ESAPD, Direcc Asistencial Noroeste Atenc Primaria, Serv Madrileno Salud, Madrid, Spain.
   [Alonso-Babarro, Alberto] Hosp Univ La Paz, Serv Madrileno Salud, Unidad Cuidados Paliat, Madrid, Spain.
C3 Hospital Universitario La Paz
RP Ruiz-López, D (corresponding author), Ctr Salud Legazpi, Equipo Soporte Paliat Domiciliario ESAPD, Direcc Asistencial Noroeste Atenc Primaria, Serv Madrileno Salud, Madrid, Spain.
EM diego.ruiz@salud.madrid.org
RI ; Alonso-Babarro, Alberto/ABK-9517-2022
OI Ruiz-López, Diego/0000-0002-5314-4505; 
CR Alford DP, 2016, NEW ENGL J MED, V374, P301, DOI 10.1056/NEJMp1512932
   Andalucia Consejeria de Salud, 2011, US SEG OP PAC SIT TE
   Barnett ML, 2017, NEW ENGL J MED, V376, P663, DOI 10.1056/NEJMsa1610524
   Belisario JSM, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.MR000042.pub2
   Caraceni A, 2012, LANCET ONCOL, V13, pE58, DOI 10.1016/S1470-2045(12)70040-2
   Chou R, 2009, J PAIN, V10, P131, DOI 10.1016/j.jpain.2008.10.009
   Clausen TG, 1997, ACTA ANAESTH SCAND, V41, P162, DOI 10.1111/j.1399-6576.1997.tb04632.x
   Correa-Casado M, 2017, ATEN PRIM, V49, P326, DOI 10.1016/j.aprim.2016.09.003
   Dart RC, 2015, NEW ENGL J MED, V372, P241, DOI [10.1056/NEJMsa1406143, 10.1056/NEJMc1501822]
   de Marchis P, 2012, ESTUDIO MENSAJE PERI, V18
   de Rada VD, 2012, PAPERS, V97, P193
   Duhagon MA, 2013, ANN ONCOL, V24, P558, DOI 10.1093/annonc/mds610
   Fallon M, 2018, ANN ONCOL, V29, P166, DOI 10.1093/annonc/mdy152
   Frieden TR, 2016, NEW ENGL J MED, V374, P1501, DOI 10.1056/NEJMp1515917
   Giraudon I, 2013, BRIT J CLIN PHARMACO, V76, P823, DOI 10.1111/bcp.12133
   Valle MCGD, 2018, MED PALIATIVA, V25, P281, DOI [10.1016/j.medipa.2016.12.002, 10.1016/j.medipa.2016.12.002, DOI 10.1016/J.MEDIPA.2016.12.002]
   Hamunen K, 2009, EUR J PAIN, V13, P954, DOI 10.1016/j.ejpain.2008.11.006
   Hui D, 2019, JAMA-J AM MED ASSOC, V321, P511, DOI 10.1001/jama.2018.18640
   Jamison Robert N, 2014, J Opioid Manag, V10, P375, DOI 10.5055/jom.2014.0234
   Joranson DE, 2000, JAMA-J AM MED ASSOC, V283, P1710, DOI 10.1001/jama.283.13.1710
   Katz NP, 2007, CLIN J PAIN, V23, P103, DOI 10.1097/01.ajp.0000210953.86255.8f
   Mansoa SL, 2018, FMC - Formación Médica Continuada en Atención Primaria, V25, P99, DOI 10.1016/j.fmc.2017.05.010
   Llaurado O., 2006, Investigacion Y Marketing, V91, P25
   Manjiani D, 2014, OCHSNER J, V14, P208
   Martínez-Nicolás I, 2016, REV CALID ASSIST, V31, P55, DOI 10.1016/j.cali.2015.06.009
   Nguyen LMT, 2013, J PAIN SYMPTOM MANAG, V45, P506, DOI 10.1016/j.jpainsymman.2012.02.023
   ORCPex, GUIA CLIN MAN OP POT
   Peretti-Watel P, 2003, Palliat Support Care, V1, P345
   Pezalla EJ, 2017, J PAIN RES, V10, DOI 10.2147/JPR.S129553
   Portal estadistico de personal del Servicio Madrile no de Salud, COMUNIDAD DE MADRID
   Portenoy RK, 2014, J CLIN ONCOL, V32, P1662, DOI 10.1200/JCO.2013.52.5188
   Portenoy RK, 2011, LANCET, V377, P2236, DOI 10.1016/S0140-6736(11)60236-5
   Ray WA, 2016, JAMA-J AM MED ASSOC, V315, P2415, DOI 10.1001/jama.2016.7789
   Ruiz-Lopez D, 2019, REV CLIN ESP
   Scholten W, 2016, J PAIN PALLIAT CARE, V30, P4, DOI 10.3109/15360288.2015.1136368
   Scholten Willem, 2014, J Pain Palliat Care Pharmacother, V28, P40, DOI 10.3109/15360288.2013.873513
   Schuckit MA, 2016, NEW ENGL J MED, V375, P357, DOI 10.1056/NEJMra1604339
   Spitz A, 2011, BMC GERIATR, V11, DOI 10.1186/1471-2318-11-35
   Sproule B, 2009, CAN FAM PHYSICIAN, V55, P68
   Stannard C, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f5108
   Tong ST, 2019, ANN FAM MED, V17, P200, DOI 10.1370/afm.2357
   Volkow ND, 2016, NEW ENGL J MED, V374, P1253, DOI 10.1056/NEJMra1507771
   von Gunten CF, 2016, J PALLIAT MED, V19, P348, DOI 10.1089/jpm.2016.0079
   Vowles KE, 2015, PAIN, V156, P569, DOI 10.1097/01.j.pain.0000460357.01998.f1
   Weisberg DF, 2014, INT J DRUG POLICY, V25, P1124, DOI 10.1016/j.drugpo.2014.07.009
   Worrld Health Organization, 1996, CANC PAIN REL GUID O, V2nd
NR 46
TC 1
Z9 1
U1 0
U2 5
PU EDICIONES DOYMA S A
PI BARCELONA
PA TRAV DE GRACIA 17-21, 08021 BARCELONA, SPAIN
SN 0212-6567
EI 1578-1275
J9 ATEN PRIM
JI Aten. Prim.
PD JUN-JUL
PY 2021
VL 53
IS 6
AR 102040
DI 10.1016/j.aprim.2021.102040
EA APR 2021
PG 9
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SU3KV
UT WOS:000663040600007
PM 33857704
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zeng, K
   Dong, HJ
   Chen, HY
   Chen, Z
   Li, B
   Zhou, QH
AF Zeng, Ke
   Dong, Hui-Juan
   Chen, Hong-Yun
   Chen, Zhe
   Li, Bai
   Zhou, Qing-Hui
TI Wrist-Ankle Acupuncture for Pain After Transcatheter Arterial
   Chemoembolization in Patients with Liver Cancer: A Randomized Controlled
   Trial
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Liver Cancer; Transcatheter Arterial Chemoembolization; Pain;
   Acupuncture; Wrist-Ankle Acupuncture; Randomized Controlled Trial
ID HEPATOCELLULAR-CARCINOMA; BACK-PAIN
AB This study was designed to evaluate the analgesic effect of wrist-ankle acupuncture (WAA) for patients with primary liver cancer (PLC) after transcatheter arterial chemoembolization (TACE). Sixty PLC patients with post-TACE visual analog pain intensity scores greater than 3 were divided equally into two groups receiving either WAA or oral morphine sulphate (MOR) for post-TACE pain. Pain intensity scores were reassessed at 1, 2, 4, and 6 h after analgesic intervention. Patients were also monitored for adverse reactions to analgesic treatment. Pain scores recorded when the patients first felt pain after TACE showed no statistical difference between the two groups (p > 0.05). WAA and MOR had indistinguishable degrees of pain relief 1, 2, and 4 h after analgesic intervention (p > 0.05). At 6 h after intervention, the WAA group experienced significantly greater pain relief than the MOR group (p < 0.05). Incidence of abdominal distension was lower in the WAA group than in the MOR group (p < 0.05). The results suggest that WAA not only had an analgesic effect equal to or greater than MOR in PLC patients with moderate to severe post-TACE pain, but also reduced the incidence of postoperative abdominal distention.
C1 [Zeng, Ke; Dong, Hui-Juan; Chen, Hong-Yun; Chen, Zhe; Li, Bai; Zhou, Qing-Hui] Second Mil Med Univ, Sch Tradit Chinese Med, Changhai Hosp Tradit Chinese Med, Shanghai 200433, Peoples R China.
C3 Naval Medical University
RP Zhou, QH (corresponding author), Second Mil Med Univ, Sch Tradit Chinese Med, Room 2203,800 Xiangyin Rd, Shanghai 200433, Peoples R China.
EM jcimzqh@163.com
CR ANDERSSON S A, 1975, American Journal of Chinese Medicine, V3, P311, DOI 10.1142/S0192415X75000396
   [Anonymous], 2005, CHIN J INTEGRATED TR
   Barone M, 2003, HEPATO-GASTROENTEROL, V50, P183
   Chen X.N., 2007, CHIN J PRACT NURS, V23, P26
   Chu Z, 1997, J Tradit Chin Med, V17, P280
   Han J.S., 2006, MOD ONCOL, V14, P1274
   [胡侠 Hu Xia], 2004, [中国针灸, Chinese Acupuncture and Moxibustion], V24, P149
   [胡侠 Hu Xia], 2004, [中国针灸, Chinese Acupuncture and Moxibustion], V24, P361
   JADAD AR, 1995, JAMA-J AM MED ASSOC, V274, P1870, DOI 10.1001/jama.274.23.1870
   Jamison RN, 1998, SPINE, V23, P2591, DOI 10.1097/00007632-199812010-00014
   Lao H.H., 1999, WRIST ANKLE ACUPUNCT, P1
   Lee HS, 1997, CANCER-AM CANCER SOC, V79, P2087, DOI 10.1002/(SICI)1097-0142(19970601)79:11<2087::AID-CNCR5>3.0.CO;2-M
   Lee SH, 2001, CARDIOVASC INTER RAD, V24, P368, DOI 10.1007/s00270-001-0073-z
   Li X.Z., 2004, CLIN MED, V24, P22
   Li Z.P., 2006, J PRACT DIAGN THER, V20, P613
   Liang J.F., 2003, ZHEJIANG J PREV MED, V15, P14
   Lin JG, 2008, AM J CHINESE MED, V36, P635, DOI 10.1142/S0192415X08006107
   Lin JG, 2012, AM J CHINESE MED, V40, P219, DOI 10.1142/S0192415X12500176
   Lu D.Z., 2004, J GUANGDONG MED COLL, V22, P183
   Lu X. Y., 2003, CHINESE J MODERN NUR, V20, P6
   Lu Z.Y., 2008, INTERNAL MED, P371
   Ma H.Q., 2011, CHIN FOREIGN MED RES, V9, P129
   Marra C, 2011, J ALTERN COMPLEM MED, V17, P239, DOI 10.1089/acm.2010.0256
   Meng Zhi-Qiang, 2003, Zhong Xi Yi Jie He Xue Bao, V1, P187, DOI 10.3736/jcim20030312
   Qin J., 2004, NURS J CHIN PLA, V21, P7
   Shu Shi, 2011, Zhong Xi Yi Jie He Xue Bao, V9, P605
   Su Jiang-tao, 2010, Zhongguo Zhen Jiu, V30, P617
   Tian Y., 2007, JIANGSU J TRADIT CHI, V39, P47
   Wang J. Y., 2010, J NANJING I PHYS ED, V9, P29
   Wang Q, 2012, AM J CHINESE MED, V40, P1157, DOI 10.1142/S0192415X12500851
   Xu M, 2013, AM J CHINESE MED, V41, P1, DOI 10.1142/S0192415X13500018
   Yang J.Y., 2005, THEORY PRACTICE INTE, P236
   Zhai XF, 2013, J INTEGR MED-JIM, V11, P90, DOI 10.3736/jintegrmed2013021
   Zhang Huo-Jun, 2008, Zhong Xi Yi Jie He Xue Bao, V6, P907, DOI 10.3736/jcim20080906
   Zhang X. M., 2002, Proceedings Fifteenth International Symposium on Mathematical Theory of Networks and Systems, P1
   Zhou Q.H., 2002, WRIST ANKLE ACUPUNCT, P1
   Zhou QH, 2005, J ZHEJIANG COLL TRAD, V29, P53
   Zhou Y.L., 2005, ZHEJIANG CLIN MED J, V7, P397
   Zhu Z, 1998, J Tradit Chin Med, V18, P192
NR 39
TC 36
Z9 44
U1 1
U2 65
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2014
VL 42
IS 2
BP 289
EP 302
DI 10.1142/S0192415X14500190
PG 14
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA AD2UR
UT WOS:000333091500003
PM 24707863
DA 2026-01-16
ER

PT J
AU Li, HJ
   Doorenbos, AZ
   Chen, ZJ
   Choi, H
   Ma, WW
   Danciu, O
   Patil, CL
   Gao, S
   Lif, N
   Schlaeger, JM
AF Li, Hongjin
   Doorenbos, Ardith Z.
   Chen, Zhengjia
   Choi, Hannah
   Ma, Weiwei
   Danciu, Oana
   Patil, Crystal L.
   Gao, Shuang
   Lif, Natalie
   Schlaeger, Judith M.
TI Feasibility and Acceptability of Integrating Acupuncture for Management
   of Multiple Symptoms in Medically Underserved Breast Cancer Survivors
SO CANCERS
LA English
DT Article
DE acupuncture; health disparities; medically underserved; breast cancer
   survivors; symptom management
ID PAIN
AB Background/Objectives: Breast cancer survivors undergoing long-term endocrine therapy often experience multiple symptoms, including pain, fatigue, sleep disturbance, hot flashes, anxiety, and depression. This study explored the feasibility and acceptability of integrating acupuncture for symptom management in medically underserved breast cancer survivors. Methods: This randomized controlled trial was conducted at two clinics serving medically underserved populations. Breast cancer survivors (N = 62) were randomized to receive acupuncture (n = 31) or usual care (n = 31). The acupuncture group underwent 10 sessions over 5 weeks. Symptoms were assessed at baseline and Weeks 6 and 12. Results: The majority of participants (55%) were Black, mean age was 55.2 +/- 9.3 years, and 62.9% had a household income below $55,000. Retention (90.3%), engagement (93.1%), and acceptability (92.8%) rates were high, demonstrating that integrating acupuncture into care for medically underserved breast cancer survivors is both feasible and acceptable. At Week 6, the acupuncture group showed significant reduction compared to the usual care group in pain, fatigue, sleep disturbance, depression, anxiety, and the symptom cluster score. All improvements persisted to Week 12 except for those in anxiety. Conclusions: Integrating acupuncture for symptom management in medically underserved breast cancer survivors is both feasible and acceptable. This approach offers potential benefits for reducing multiple symptoms and addressing health disparities.
C1 [Li, Hongjin; Doorenbos, Ardith Z.; Choi, Hannah; Lif, Natalie; Schlaeger, Judith M.] Univ Illinois, Coll Nursing, Chicago, IL 60612 USA.
   [Li, Hongjin; Doorenbos, Ardith Z.; Chen, Zhengjia; Ma, Weiwei; Danciu, Oana] Univ Illinois, Canc Ctr, Chicago, IL 60612 USA.
   [Patil, Crystal L.] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA.
   [Gao, Shuang] Univ Illinois, Coll Med, Chicago, IL 60612 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Michigan System; University of Michigan; University of
   Illinois System; University of Illinois Chicago; University of Illinois
   Chicago Hospital
RP Li, HJ (corresponding author), Univ Illinois, Coll Nursing, Chicago, IL 60612 USA.; Li, HJ (corresponding author), Univ Illinois, Canc Ctr, Chicago, IL 60612 USA.
EM hongjin@uic.edu; ardith@uic.edu; znchen@uic.edu; hchoi213@uic.edu;
   wma29@uic.edu; ocdanciu@uic.edu; clpatil@med.umich.edu; sgao20@uic.edu;
   nlif2@uic.edu; jschlaeg@uic.edu
RI Ma, Weiwei/JGD-2360-2023; Patil, Crystal/H-7509-2016; schlaeger,
   Judith/N-4482-2017
OI Lif, Natalie/0009-0003-6719-3265; Gao, Shuang/0000-0001-9950-6228;
   Patil, Crystal/0000-0003-4536-4599; Choi, Hannah/0000-0002-1278-7969;
   Li, Hongjin/0000-0002-5466-1192; schlaeger, Judith/0000-0002-3754-6176;
   Chen, Zhengjia/0000-0002-6301-4931
FU National Center for Complementary and Integrative Health;  [R34
   AT012084];  [K24 AT011995-01]
FX This work was supported by the National Center for Complementary and
   Integrative Health (R34 AT012084 and K24 AT011995-01).
CR Alcalá HE, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-930
   Alnaim L, 2022, EUR J BREAST HEALTH, V18, P292, DOI 10.4274/ejbh.galenos.2022.2022-5-8
   [Anonymous], 2010, BMJ-BRIT MED J, V340, DOI DOI 10.1136/BMJ.C332
   [Anonymous], ILLINOIS DEP HEALTHC
   Bjerkeset E, 2020, BREAST CANCER RES TR, V180, P63, DOI 10.1007/s10549-020-05522-8
   Caraballo C, 2022, JAMA-HEALTH FORUM, V3, DOI 10.1001/jamahealthforum.2022.3856
   Carmen A, 2023, BREAST CANCER RES TR, V198, P475, DOI 10.1007/s10549-022-06808-9
   Cella D, 2019, VALUE HEALTH, V22, P537, DOI 10.1016/j.jval.2019.02.004
   Choi TY, 2022, CANCERS, V14, DOI 10.3390/cancers14184419
   Deyo RA, 2016, PAIN MED, V17, P314, DOI 10.1093/pm/pnv046
   Eliassen FM, 2023, BMC CANCER, V23, DOI 10.1186/s12885-023-11122-8
   Elshafie S, 2025, CANCER-AM CANCER SOC, V131, DOI 10.1002/cncr.35550
   Harris PA, 2019, J BIOMED INFORM, V95, DOI 10.1016/j.jbi.2019.103208
   Kang D, 2022, CANCER RES TREAT, V54, P10, DOI 10.4143/crt.2020.1200
   LAIRD NM, 1982, BIOMETRICS, V38, P963, DOI 10.2307/2529876
   Li HJ, 2024, CONTEMP CLIN TRIALS, V136, DOI 10.1016/j.cct.2023.107387
   Li HJ, 2021, J ALTERN COMPLEM MED, V27, P1084, DOI 10.1089/acm.2021.0133
   Ma Y, 2024, ASIA-PAC J ONCOL NUR, V11, DOI 10.1016/j.apjon.2023.100364
   Mandelblatt JS, 2020, CANCER-AM CANCER SOC, V126, P1183, DOI 10.1002/cncr.32663
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mao JJ, 2015, J CLIN ONCOL, V33, P3615, DOI 10.1200/JCO.2015.60.9412
   Miller David W, 2021, Glob Adv Health Med, V10, p21649561211042574, DOI [10.1177/21649561211042574, 10.1177/21649561211042574]
   SAS Institute, 2019, SAS Certified Professional Prep Guide: Advanced Programming Using SAS 9.4
   Sloan JA, 2001, J CLIN ONCOL, V19, P4280, DOI 10.1200/JCO.2001.19.23.4280
   Tangkiatkumjai M, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-03157-2
   Tarver WL, 2025, J CANCER SURVIV, V19, P1956, DOI 10.1007/s11764-024-01609-z
   Teets R, 2023, GLOB ADV INTEGR MED, V12, DOI 10.1177/27536130231202515
   Terwee CB, 2021, QUAL LIFE RES, V30, P2729, DOI 10.1007/s11136-021-02925-y
   Tonorezos E, 2024, JNCI-J NATL CANCER I, V116, P1784, DOI 10.1093/jnci/djae135
   Vallerand AH, 2005, PAIN MED, V6, P242, DOI 10.1111/j.1526-4637.2005.05038.x
   Whisenant MS, 2022, CANCER NURS, V45, P253, DOI 10.1097/NCC.0000000000001019
   Wilkie DJ, 2003, J PAIN SYMPTOM MANAG, V25, P213, DOI 10.1016/S0885-3924(02)00638-3
   Wilkie DJ, 2001, FAM COMMUNITY HEALTH, V24, P48, DOI 10.1097/00003727-200110000-00007
   Zhang YZ, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.646315
NR 34
TC 2
Z9 2
U1 2
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JAN
PY 2025
VL 17
IS 2
AR 304
DI 10.3390/cancers17020304
PG 14
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA T2W9A
UT WOS:001403685100001
PM 39858086
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Patel, JN
   Miller, K
   Symanowski, JT
   Edelen, C
AF Patel, Jai Narendra
   Miller, Katherine
   Symanowski, James Thomas
   Edelen, Connie
TI Efficacy of acupuncture (ACU) therapy for cancer-related pain management
   in oncology patients (pts)
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT Palliative Care in Oncology Symposium
CY OCT 09-10, 2015
CL Boston, MA
C1 Levine Canc Inst, Charlotte, NC USA.
   Carolinas Healthcare Syst, Levine Canc Inst, Charlotte, NC USA.
   Carolinas Palliat Care, Levine Canc Inst, Charlotte, NC USA.
C3 Carolinas HealthCare System
RI Patel, Jai/IQT-8937-2023
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD OCT 10
PY 2015
VL 33
IS 29
SU S
MA 196
DI 10.1200/jco.2015.33.29_suppl.196
PG 1
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology
GA DO9LD
UT WOS:000378107000191
DA 2026-01-16
ER

PT J
AU Garcia, JBS
   Lech, O
   Kraychete, DC
   Rico, MA
   Hernández-Castro, JJ
   Colimon, F
   Guerrero, C
   Gallegos, MS
   Lara-Solares, A
   Cantisani, JAF
   Amescua-Garcia, C
   Núñez, MDG
   Cook, MDB
   Iskandar, AJ
   Sierra, PB
AF Santos Garcia, Joao Batista
   Lech, Osvandre
   Kraychete, Durval Campos
   Antonieta Rico, Maria
   Hernandez-Castro, John Jairo
   Colimon, Frantz
   Guerrero, Carlos
   Sempertegui Gallegos, Manuel
   Lara-Solares, Argelia
   Flores Cantisani, Jose Alberto
   Amescua-Garcia, Cesar
   Guillen Nunez, Maria del Rocio
   Berenguel Cook, Maria del Rosario
   Jreige Iskandar, Aziza
   Bonilla Sierra, Patricia
TI The role of tramadol in pain management in Latin America: a report by
   the Change Pain Latin America Advisory Panel
SO CURRENT MEDICAL RESEARCH AND OPINION
LA English
DT Review
DE Pain management; tramadol; Latin America; abuse; prescription control
ID PRESCRIPTION OPIOID ANALGESICS; LOW-BACK-PAIN;
   PHARMACOLOGICAL-TREATMENT; POSTOPERATIVE PAIN; NEUROPATHIC PAIN; ABUSE
   LIABILITY; EFNS GUIDELINES; DRUG-ABUSE; OSTEOARTHRITIS; CHILDREN
AB Objective: Change Pain Latin America (CPLA) was created to enhance chronic pain understanding and develop pain management improving strategies in this region. During its seventh meeting (August 2016), the main objective was to discuss tramadol's role in treating pain in Latin America. Furthermore, potential pain management consequences were considered, if tramadol was to become more stringently controlled.
   Methods: Key topics discussed were: main indications for prescribing tramadol, its pharmacological characteristics, safety and tolerability, effects of restrictions on its availability and use, and consequent impact on pain care quality.
   Results: The experts agreed that tramadol is used to treat a wide spectrum of non-oncological pain conditions (e.g. post-surgical, musculoskeletal, post-traumatic, neuropathic, fibromyalgia), as well as cancer pain. Its relevance when treating special patient groups (e.g. the elderly) is recognized. The main reasons for tramadol's high significance as a treatment option are: its broad efficacy, an inconspicuous safety profile and its availability, considering that access to strong analgesics - mainly controlled drugs (classical opioids) - is highly restricted in some countries. The CPLA also agreed that tramadol is well tolerated, without the safety issues associated with long-term nonsteroidal anti-inflammatory drug (NSAID) use, with fewer opioid-like side effects than classical opioids and lower abuse risk.
   Conclusions: In Latin America, tramadol is a valuable and frequently used medication for treating moderate to severe pain. More stringent regulations would have significant impact on its availability, especially for outpatients. This could cause regression to older and frequently inadequate pain management methods, resulting in unnecessary suffering for many Latin American patients.
C1 [Santos Garcia, Joao Batista] Univ Fed Maranhao, Pain & Palliat Care, Sao Luis, MA, Brazil.
   [Lech, Osvandre] UFFS HSVP IOT, Shoulder & Elbow Serv, Passo Fundo, Brazil.
   [Kraychete, Durval Campos] Univ Fed Bahia, Pain Outpatient Clin, Salvador, BA, Brazil.
   [Antonieta Rico, Maria] Univ Desarrollo, Clin Alemana, Santiago, Chile.
   [Hernandez-Castro, John Jairo] Univ Rosario MEDERI, Pain Med & Palliat Care, Bogota, Colombia.
   [Colimon, Frantz] Ctr Oncol Antioquia, Intervent Pain Management & Palliat Care Unit, Medellin, Antioquia, Colombia.
   [Guerrero, Carlos] Univ Los Andes, Hosp Univ Fdn Santa Fe, Bogota, Colombia.
   [Sempertegui Gallegos, Manuel] Hosp Metropolitano, Pain Clin, Quito, Ecuador.
   [Lara-Solares, Argelia] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Pain Med & Palliat Care, Mexico City, DF, Mexico.
   [Flores Cantisani, Jose Alberto] IMSS, Programa Reg Cuidados Paliat, Unidad Med Alta Especialidad 25, Monterrey, NL, Mexico.
   [Amescua-Garcia, Cesar] Hosp Angeles, Tijuana, Mexico.
   [Guillen Nunez, Maria del Rocio] Hosp Med Sur, Med Dolor & Cuidados Paliat, Mexico City, DF, Mexico.
   [Berenguel Cook, Maria del Rosario] Totalcare Oncosalud Auna, Dept Med Paliat & Tratamiento Dolor, Lima, Peru.
   [Jreige Iskandar, Aziza] UCV, Unidad Rehabil DM, Rehabil Residency Program, Maracay, Venezuela.
   [Bonilla Sierra, Patricia] Inst Med Floresta, Inst Oncol Luis Razetti Pain Clin & Palliat Care, Caracas, Venezuela.
C3 Universidade Federal do Maranhao; Universidade Federal da Bahia;
   Universidad del Desarrollo; Clinica Alemana; Universidad del Rosario;
   Universidad de los Andes (Colombia); Instituto Nacional de Ciencias
   Medicas y Nutricion Salvador Zubiran - Mexico; University of Central
   Venezuela
RP Garcia, JBS (corresponding author), Univ Fed Maranhao, Pain & Palliat Care, Sao Luis, MA, Brazil.
EM jbgarcia@uol.com.br
RI Kraychete, Durval/E-9576-2014; Garcia, João Batista Santos/O-6170-2018
OI Kraychete, Durval/0000-0001-6561-6584; Garcia, João Batista
   Santos/0000-0002-3597-6471
FU Grunenthal
FX Change Pain Latin America is supported by an educational grant from
   Grunenthal.
CR Adams EH, 2006, J PAIN SYMPTOM MANAG, V31, P465, DOI 10.1016/j.jpainsymman.2005.10.006
   Allegaert K, 2015, CLIN PHARMACOKINET, V54, P167, DOI 10.1007/s40262-014-0191-9
   [Anonymous], 2011, WORLD MED SITUATION
   [Anonymous], TRAM MAN PAIN AD PAT
   Rico MA, 2016, PAIN MED, V17, P704, DOI 10.1111/pme.12905
   Attal N, 2006, EUR J NEUROL, V13, P1153, DOI 10.1111/j.1468-1331.2006.01511.x
   Attal N, 2010, EUR J NEUROL, V17, P1113, DOI 10.1111/j.1468-1331.2010.02999.x
   Bamigbade TA, 1998, PAIN REV, V5, P155, DOI 10.1191/096813098668122984
   Benzon H.T., 2014, Practical Management of Pain, V5th
   Berterame S, 2016, LANCET, V387, P1644, DOI 10.1016/S0140-6736(16)00161-6
   Bösenberg AT, 1998, ANAESTHESIA, V53, P960, DOI 10.1046/j.1365-2044.1998.00526.x
   Cavalieri TA, 2007, J AM OSTEOPATH ASSOC, V107, pES10
   Cepeda MS, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005522.pub2
   Chaparro LE, 2014, SPINE, V39, P556, DOI 10.1097/BRS.0000000000000249
   Chou R, 2007, ANN INTERN MED, V147, P478, DOI 10.7326/0003-4819-147-7-200710020-00006
   Cicero TJ, 2007, PAIN MED, V8, P157, DOI 10.1111/j.1526-4637.2006.00259.x
   Cicero TJ, 2005, PHARMACOEPIDEM DR S, V14, P851, DOI 10.1002/pds.1113
   COLLART L, 1993, SCHWEIZ MED WSCHR, V123, P2241
   Commission on Narcotic Drugs, 2011, ECN72011CRP3 COMM NA
   Cousins MJ, 2011, PAIN, V152, P2673, DOI 10.1016/j.pain.2011.09.012
   Desmeules JA, 1996, BRIT J CLIN PHARMACO, V41, P7, DOI 10.1111/j.1365-2125.1996.tb00152.x
   Duhmke RM, 2006, COCHRANE DB SYST REV, V3
   Epstein DH, 2006, BIOL PSYCHOL, V73, P90, DOI 10.1016/j.biopsycho.2006.01.010
   Gillen C, 2000, N-S ARCH PHARMACOL, V362, P116, DOI 10.1007/s002100000266
   Grond S, 2004, CLIN PHARMACOKINET, V43, P879, DOI 10.2165/00003088-200443130-00004
   GROND S, 1995, PAIN, V62, P313, DOI 10.1016/0304-3959(94)00274-I
   Gupta A, 2013, PAIN MANAG, V3, P315, DOI [10.2217/pmt.13.23, 10.2217/PMT.13.23]
   Harbin M, 2014, CAN FAM PHYSICIAN, V60, pE166
   Haslam C, 2008, CLIN INTERV AGING, V3, P111
   Hassanian-Moghaddam H, 2015, RES PHARM SCI, V10, P544
   Hernandez JJ, 2011, MED DEL DOLOR, P19
   HOUMES RJM, 1992, ANESTH ANALG, V74, P510
   Hsu Shao-Keh, 2012, Acta Anaesthesiol Taiwan, V50, P101, DOI 10.1016/j.aat.2012.08.008
   *INCB, 2006, EINCB20051 UN
   International Pain Summit Of The International Association For The Study Of Pain, 2011, J Pain Palliat Care Pharmacother, V25, P29, DOI 10.3109/15360288.2010.547560
   Jorge LF, 1999, PHARMACOGENETICS, V9, P217
   Kirchheiner J, 2008, J CLIN PSYCHOPHARM, V28, P78, DOI 10.1097/JCP.0b013e318160f827
   Knisely JS, 2002, DRUG ALCOHOL DEPEN, V68, P15, DOI 10.1016/S0376-8716(02)00107-2
   Langford RM, 1998, ACUTE PAIN, V1, P7
   Lara-Solares A, 2017, PAIN MANAG, V7, P287, DOI 10.2217/pmt-2017-0006
   Lara-Solares A, 2017, PAIN MANAG, V7, P207, DOI 10.2217/pmt-2016-0065
   Lassen D, 2015, CLIN PHARMACOKINET, V54, P825, DOI 10.1007/s40262-015-0268-0
   Leppert W, 2005, SUPPORT CARE CANCER, V13, P5, DOI 10.1007/s00520-004-0720-4
   Mamdani M, 2004, BRIT MED J, V328, P1415, DOI 10.1136/bmj.38068.716262.F7
   Martins RO, 2015, J BRAS PNEUMOL, V41, P238, DOI 10.1590/S1806-37132015000004415
   Mildh LH, 1999, J CLIN ANESTH, V11, P310, DOI 10.1016/S0952-8180(99)00047-1
   National Opioid Use Guide Guideline Group, CAN GUID SAF EFF US
   NICE, 2015, NONST ANT DRUGS KEY
   Petrone D, 1999, J CLIN PHARM THER, V24, P115, DOI 10.1046/j.1365-2710.1999.00203.x
   Raffa RB, 2008, J CLIN PHARM THER, V33, P101, DOI 10.1111/j.1365-2710.2008.00897.x
   Raffa RB, 2013, ENCY PAIN, P1071
   Rosenthal NR, 2004, J AM GERIATR SOC, V52, P374, DOI 10.1111/j.1532-5415.2004.52108.x
   Sacerdote P, 1997, PAIN, V72, P325, DOI 10.1016/S0304-3959(97)00055-9
   Sacerdote Paola, 2008, Curr Opin Support Palliat Care, V2, P14, DOI 10.1097/SPC.0b013e3282f5272e
   Garcia JBS, 2014, REV BRAS ANESTESIOL, V64, P140, DOI [10.1016/j.bjane.2013.03.004, 10.1016/j.bjan.2013.03.004]
   SCHAFFER J, 1986, ANAESTHESIST, V35, P408
   Schneider MF, 2009, PHARMACOEPIDEM DR S, V18, P778, DOI 10.1002/pds.1780
   Schnitzer TJ, 2002, J PAIN SYMPTOM MANAG, V23, pS24, DOI 10.1016/S0885-3924(02)00372-X
   Scott LJ, 2000, DRUGS, V60, P139, DOI 10.2165/00003495-200060010-00008
   Single Convention on Narcotic Drugs, 1961, SINGL CONV NARC DRUG
   Stassinos GL, 2017, CLIN TOXICOL PHILA P, V53, P707
   Tarkkila P, 1997, J CLIN ANESTH, V9, P582, DOI 10.1016/S0952-8180(97)00147-5
   Tarkkila P, 1998, EUR J ANAESTH, V15, P64, DOI 10.1097/00003643-199801000-00013
   van Amsterdam Jan, 2015, Curr Drug Abuse Rev, V8, P3, DOI 10.2174/187447370801150611184218
   Vazzana M, 2015, BIOMED PHARMACOTHER, V70, P234, DOI 10.1016/j.biopha.2015.01.022
   VICKERS MD, 1995, EUR J ANAESTH, V12, P265
   Walton Betancourth SB, 2014, ARCH DIS CHILD S, V99, pA13
   Whelton A., 1999, Am J Med, V106, p13S, DOI [10.1016/S0002-9343(99)00113-8, DOI 10.1016/S0002-9343(99)00113-8]
   Whittle SL, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003113.pub3
   WHO, 2014, WHO TECH REP SER, V986, P1
   Zhou SF, 2009, CLIN PHARMACOKINET, V48, P689, DOI 10.2165/11318030-000000000-00000
NR 71
TC 11
Z9 12
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-7995
EI 1473-4877
J9 CURR MED RES OPIN
JI Curr. Med. Res. Opin.
PY 2017
VL 33
IS 9
BP 1615
EP 1621
DI 10.1080/03007995.2017.1354821
PG 7
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA FE1DZ
UT WOS:000407959900009
PM 28696784
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Liu, SF
   Chen, QD
   Zhang, QG
   Tao, K
   Li, CH
   Chang, BL
   Wang, WF
   Wu, Z
AF Liu, Shengfu
   Chen, Qiudan
   Zhang, Qinggang
   Tao, Kun
   Li, Changhong
   Chang, Baolei
   Wang, Weifeng
   Wu, Zhong
TI Electroacupuncture combined with extracorporeal shock wave therapy
   improves pain symptoms and inflammatory factor levels in knee
   osteoarthritis patients
SO HELIYON
LA English
DT Article
DE Electroacupuncture; Extracorporeal shock wave therapy; Knee
   osteoarthritis; Synovial fluid
ID PLANTAR FASCIITIS; SUBCHONDRAL BONE; ACUPUNCTURE; CARTILAGE; MODEL
AB Objective: To compare the clinical efficacy and safety of electroacupuncture combined with extracorporeal shock wave therapy (EESWT) and extracorporeal shock wave therapy (ESWT) in the treatment of knee osteoarthritis (KOA).Methods: A total of 135 KOA patients who received EESWT treatment were selected as the EESWT group, and 135 KOA patients who received extracorporeal shock wave therapy (ESWT) were selected as the ESWT group. The clinical efficacy, inflammatory factors in joint synovial fluid and adverse events during treatment were compared before and after treatment.Results: The clinical effective rate of patients in the EESWT group (89.63 %) after treatment was significantly higher than that of the ESWT group (74.81 %) (p < 0.01). The lysholm kness (LKSS) score and range of motion (ROM) of the patients in the EESWT group after treatment were higher than those of the ESWT group, while Lequesne index score, visual analogue scale (VAS) score and Western Ontario and McMaster Universities Arthritis Index (WOMAC) were lower than those of the ESWT group (p < 0.01). Compared with ESWT group, the changes in the expression levels of nitric oxide (NO), superoxide dismutase (SOD), interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase-3 (MMP-3), and transforming growth factor beta 1 (TGF-beta 1) in the synovial fluid of the EESWT group after treatment were significantly greater than those of the ESWT group (p < 0.01). No significant difference in the incidence of adverse events between the EESWT group and the ESWT group (p > 0.05).Conclusion: EESWT significantly improves pain symptoms and inflammatory factor levels in KOA patients and is an optional KOA treatment option worthy of clinical attention.
C1 [Liu, Shengfu; Zhang, Qinggang; Tao, Kun; Wang, Weifeng; Wu, Zhong] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Orthoped, Shanghai 200072, Peoples R China.
   [Chen, Qiudan] Fudan Univ, Jingan Dist Ctr Hosp Shanghai, Dept Cent Lab, Clin Lab, Shanghai 200040, Peoples R China.
   [Li, Changhong] Peoples Hosp Gengma Dai & Va Autonomous Cty, Dept Surg 2, Lincang 677599, Yunnan, Peoples R China.
   [Chang, Baolei] Ma Anshan 17 Met Hosp, Maanshan 243000, Anhui, Peoples R China.
   [Wang, Weifeng] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Lab Med, Shanghai 200032, Peoples R China.
   [Wang, Weifeng] 301 Yanchang Zhong Rd, Shanghai 200072, Peoples R China.
C3 Tongji University; Fudan University; Shanghai University of Traditional
   Chinese Medicine
RP Wang, WF; Wu, Z (corresponding author), Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Orthoped, Shanghai 200072, Peoples R China.; Chang, BL (corresponding author), Ma Anshan 17 Met Hosp, Maanshan 243000, Anhui, Peoples R China.; Wang, WF (corresponding author), 301 Yanchang Zhong Rd, Shanghai 200072, Peoples R China.
EM baozi19820607403@sina.com; weifengdangdao@163.com; wuzhong0515@126.com
RI wang, weifeng/N-4140-2013
FU National Natural Science Foundation of China of the Shanghai Tenth
   people's hospital [04.03.19.162]; Clinical Research Project of Shanghai
   Municipal Health Commission [202140240]
FX This work was supported by the Training Program of the National Natural
   Science Foundation of China of the Shanghai Tenth people's hospital (NO:
   04.03.19.162) and the Clinical Research Project of Shanghai Municipal
   Health Commission (202140240).
CR AABAKKEN L, 1990, SCAND J GASTROENTERO, V25, P443, DOI 10.3109/00365529009095513
   Abe Y, 2014, CIRC J, V78, P2915, DOI 10.1253/circj.CJ-14-0230
   Aringer M, 2022, ANN RHEUM DIS, V81, DOI 10.1136/annrheumdis-2020-217105
   Avendaño-Coy J, 2020, INT J SURG, V82, P64, DOI 10.1016/j.ijsu.2020.07.055
   Bacchetti P, 2002, ANESTHESIOLOGY, V97, P1028, DOI 10.1097/00000542-200210000-00050
   Bao Fei, 2011, Zhongguo Zhen Jiu, V31, P241
   Chen JW, 2020, EQUINE VET J, V52, P449, DOI 10.1111/evj.13183
   Chen LX, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.10715
   Cheng L, 2019, J SPORT MED PHYS FIT, V59, P822, DOI 10.23736/S0022-4707.18.09023-0
   Cheng Xiangjuan, 2015, Zhonghua Xin Xue Guan Bing Za Zhi, V43, P259
   Deyle GD, 2020, NEW ENGL J MED, V382, P1420, DOI 10.1056/NEJMoa1905877
   Du C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020290
   Gollwitzer H, 2015, J BONE JOINT SURG AM, V97A, P701, DOI 10.2106/JBJS.M.01331
   Hashimoto S, 2019, AM J SPORT MED, V47, P2937, DOI 10.1177/0363546519871059
   Hawker GA, 2011, OSTEOARTHR CARTILAGE, V19, P366, DOI 10.1016/j.joca.2011.01.021
   Hsiao CC, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194934
   Imamura M, 2015, INT J INFLAMM, V2015, DOI 10.1155/2015/329792
   Jenei-Lanzl Z, 2019, CELL SIGNAL, V53, P212, DOI 10.1016/j.cellsig.2018.10.005
   Ju ZY, 2015, INT J CLIN EXP MED, V8, P18981
   Kan HS, 2019, HONG KONG MED J, V25, DOI 10.12809/hkmj187600
   Karan A, 2003, CLIN RHEUMATOL, V22, P397, DOI 10.1007/s10067-003-0761-y
   Kasemsuk T, 2016, CLIN RHEUMATOL, V35, P2531, DOI 10.1007/s10067-016-3363-1
   Kawcak CE, 2011, AM J VET RES, V72, P772, DOI 10.2460/ajvr.72.6.772
   Kolasinski SL, 2020, ARTHRITIS RHEUMATOL, V72, P220, DOI [10.1002/art.41142, 10.1002/acr.24131]
   LEA RD, 1995, J BONE JOINT SURG AM, V77A, P784, DOI 10.2106/00004623-199505000-00017
   Lecorney J, 2018, JOINT BONE SPINE, V85, P605, DOI 10.1016/j.jbspin.2017.10.002
   Min SC, 2017, CLIN RHEUMATOL, V36, P2351, DOI 10.1007/s10067-017-3690-x
   Ng MML, 2003, J ALTERN COMPLEM MED, V9, P641, DOI 10.1089/107555303322524490
   Okur SÇ, 2019, J MUSCULOSKEL NEURON, V19, P178
   Pengas Ioannis, 2018, J Exp Orthop, V5, P21, DOI [10.1186/s40634-018-0132-x, 10.1186/s40634-018-0132-x]
   Qin D, 2019, J ETHNOPHARMACOL, V244, DOI 10.1016/j.jep.2019.112045
   Roos EM, 2016, NAT REV RHEUMATOL, V12, P92, DOI 10.1038/nrrheum.2015.135
   Santangelo KS, 2012, OSTEOARTHR CARTILAGE, V20, P1610, DOI 10.1016/j.joca.2012.08.011
   Schepens SL, 2012, J GERONTOL A-BIOL, V67, P1114, DOI 10.1093/gerona/gls076
   Sharma L, 2021, NEW ENGL J MED, V384, P51, DOI 10.1056/NEJMcp1903768
   Shi GX, 2020, J PAIN RES, V13, P2171, DOI 10.2147/JPR.S256950
   Shi XW, 2020, BIOMED PHARMACOTHER, V123, DOI 10.1016/j.biopha.2019.109724
   Suther KR, 2018, PEDIATR RADIOL, V48, P1567, DOI 10.1007/s00247-018-4187-8
   Tang HY, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000015119
   Tao R, 2015, INFLAMMATION, V38, P1546, DOI 10.1007/s10753-015-0129-x
   TEGNER Y, 1985, CLIN ORTHOP RELAT R, P43
   Vitali M, 2019, J DRUG ASSESS, V8, P77, DOI 10.1080/21556660.2019.1605370
   Wang CJ, 2017, INT J MED SCI, V14, P213, DOI 10.7150/ijms.17469
   Wang CJ, 2012, J SURG RES, V178, P196, DOI 10.1016/j.jss.2012.01.010
   Wang CJ, 2011, ARCH ORTHOP TRAUM SU, V131, P1153, DOI 10.1007/s00402-011-1289-2
   Wang HJ, 2017, INT J UROL, V24, P573, DOI 10.1111/iju.13403
   Wang TT, 2013, ANAL CHEM, V85, P9486, DOI 10.1021/ac400987u
   Witt C, 2005, LANCET, V366, P136, DOI 10.1016/S0140-6736(05)66871-7
   Wu GW, 2019, CHIN J INTEGR MED, V25, P677, DOI 10.1007/s11655-018-2916-8
   Yu H, 2019, AM J PHYSIOL-LUNG C, V317, pL569, DOI 10.1152/ajplung.00080.2018
   Yuan PH, 2019, NEUROUROL URODYNAM, V38, P1457, DOI 10.1002/nau.24017
   Yuan XC, 2018, J PAIN RES, V11, P2797, DOI 10.2147/JPR.S171664
   Yue Ping, 2016, Zhen Ci Yan Jiu, V41, P235
   Zhang RX, 2014, ANESTHESIOLOGY, V120, P482, DOI 10.1097/ALN.0000000000000101
NR 54
TC 3
Z9 3
U1 1
U2 12
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD OCT
PY 2023
VL 9
IS 10
AR e20771
DI 10.1016/j.heliyon.2023.e20771
EA OCT 2023
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Z2MC3
UT WOS:001110459900001
PM 37842584
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Garcia, MK
   Cohen, L
   Spano, M
   Spelman, A
   Hashmi, Y
   Chaoul, A
   Wei, Q
   Lopez, G
AF Garcia, M. Kay
   Cohen, Lorenzo
   Spano, Michael
   Spelman, Amy
   Hashmi, Yousra
   Chaoul, Alejandro
   Wei, Qi
   Lopez, Gabriel
TI Inpatient Acupuncture at a Major Cancer Center
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE cancer; oncology; integrative medicine; acupuncture; inpatient
ID COMPLEMENTARY THERAPIES; ONCOLOGY; MODEL; PAIN
AB Background: Use of complementary and integrative therapies is increasing among cancer patients, but data regarding the impact treatments such as acupuncture have in an inpatient oncology setting are limited. Methods: Patients who received acupuncture in an inpatient hospital environment between December 2014 and December 2015 were asked to complete a modified Edmonton Symptom Assessment Scale (ESAS; 0-10 scale) before and after each visit. Pre- and post-treatment scores were examined for each symptom using paired t tests. Results: A total of 172 inpatients were treated with acupuncture in their hospital beds (257 visits). Thirty percent (n = 51) received at least one additional follow-up treatment (mean visits/patient = 1.5). Completion rate of the modified ESAS after acupuncture was 42%. The most common reasons for not completing the post-treatment ESAS were patient too drowsy or patient fell asleep (72%). For patients who reported a baseline symptom score 1, the greatest improvements (mean change +/- SD) after acupuncture on the initial visit were found for pain (-1.8 +/- 2.2; n = 69; P < .0001), nausea (-1.2 +/- 1.9; n = 30; P < .001), anxiety (-0.8 +/- 1.8; n = 36; P = .01), drowsiness (-0.6 +/- 1.8; n = 57; P = .02), and fatigue (-0.4 +/- 1.1; n = 67; P = .008). For patients who received at least one follow-up visit, significant improvement from baseline was found for sleep disturbance (-2.5 +/- 4.4; n = 17; P = .03), anxiety (-2.4 +/- 1.7; n = 9; P = .002), pain (-2.3 +/- 2.7; n = 20; P = .001), and drowsiness (-2.0 +/- 2.6; n = 16; P = .008). Conclusions: Patients who received inpatient acupuncture at a major cancer center experienced significant improvement after treatment for pain, sleep disturbance, anxiety, drowsiness, nausea, and fatigue.
C1 [Garcia, M. Kay; Cohen, Lorenzo; Spano, Michael; Spelman, Amy; Hashmi, Yousra; Chaoul, Alejandro; Wei, Qi; Lopez, Gabriel] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center
RP Garcia, MK (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Palliat Care Rehabil & Integrat Med, 1515 Holcombe Blvd,Unit 0462, Houston, TX 77030 USA.
EM kaygarcia@mdanderson.org
RI ; Wei, Qi/JJF-3393-2023
OI Lopez, Gabriel/0000-0002-3685-0280; 
FU Duncan Family Institute; University of Texas M.D. Anderson Cancer
   Center; National Institutes of Health [P30 CA016672]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Support
   for this study was provided in part by the Duncan Family Institute, The
   University of Texas M.D. Anderson Cancer Center, and National Institutes
   of Health grant P30 CA016672.
CR Anderson JG, 2012, J ALTERN COMPLEM MED, V18, P235, DOI 10.1089/acm.2011.0022
   Arthur K, 2012, INTEGR CANCER THER, V11, P232, DOI 10.1177/1534735411433832
   Bedard G, 2013, J PAIN SYMPTOM MANAG, V46, P192, DOI 10.1016/j.jpainsymman.2012.07.022
   Chang VT, 2000, CANCER, V88, P2164, DOI 10.1002/(SICI)1097-0142(20000501)88:9<2164::AID-CNCR24>3.0.CO;2-5
   Deng G, 2005, CA-CANCER J CLIN, V55, P109, DOI 10.3322/canjclin.55.2.109
   Deng Gary, 2004, J Support Oncol, V2, P419
   Deng L, 1997, CHINESE ACUPUNCTURE
   ENGEL GL, 1980, AM J PSYCHIAT, V137, P535
   ENGEL GL, 1977, SCIENCE, V196, P129, DOI 10.1126/science.847460
   Garcia MK, 2015, CANCER-AM CANCER SOC, V121, P3948, DOI 10.1002/cncr.29630
   Garcia MK, 2014, CURR ONCOL REP, V16, DOI 10.1007/s11912-014-0418-9
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Johnson Jill R., 2014, Journal of the National Cancer Institute Monographs, P330, DOI 10.1093/jncimonographs/lgu030
   Johnstone PAS, 2002, CANCER, V94, P1151, DOI 10.1002/cncr.10348
   Johnstone PAS, 2002, PALLIATIVE MED, V16, P235, DOI 10.1191/0269216302pm540oa
   Lao LX, 2003, ALTERN THER HEALTH M, V9, P72
   Thompson LMA, 2015, J ACUPUNCT MERIDIAN, V8, P127, DOI 10.1016/j.jams.2015.04.002
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
NR 18
TC 23
Z9 26
U1 0
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD MAR
PY 2018
VL 17
IS 1
BP 148
EP 152
DI 10.1177/1534735416685403
PG 5
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA FW2TE
UT WOS:000425156600017
PM 28050924
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Patel, J
   Edelen, C
   Symanowski, J
AF Patel, Jai
   Edelen, Connie
   Symanowski, James
TI Efficacy of Acupuncture (ACU) Therapy for Cancer-Related Pain Management
   in Oncology Patients (Pts)
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Meeting Abstract
CT Annual Assembly of the
   American-Academy-of-Hospice-and-Palliative-Medicine and the
   Hospice-and-Palliative-Nurses-Association
CY MAR 09-12, 2016
CL Chicago, IL
SP Amer Acad Hosp & Palliat Med, Hosp & Palliat Nurses Assoc
C1 [Patel, Jai; Symanowski, James] Levine Canc Inst, Charlotte, NC USA.
   [Edelen, Connie] Carolinas Healthcare Syst, Charlotte, NC USA.
C3 Carolinas HealthCare System
RI Patel, Jai/IQT-8937-2023
NR 0
TC 0
Z9 0
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD FEB
PY 2016
VL 51
IS 2
MA S729
BP 422
EP 423
DI 10.1016/j.jpainsymman.2015.12.032
PG 4
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA DI4MB
UT WOS:000373472900252
DA 2026-01-16
ER

PT J
AU Jung, MS
   Lee, JS
   Sohn, EH
   Cha, K
   Dlamini, NS
   Kim, M
AF Jung, Mi Sook
   Lee, Jin Sun
   Sohn, Eun Hee
   Cha, Kyeongin
   Dlamini, Nondumiso Satiso
   Kim, Mijung
TI Efficacy and safety of auricular acupressure for chemotherapy-induced
   peripheral neuropathy among patients with breast cancer: a study
   protocol for a randomized controlled trial
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Article
DE Peripheral neuropathy; ear; acupressure; clinical trial protocol;
   randomized controlled trial (RCT)
ID QUALITY-OF-LIFE; GENERAL FACT-G; FUNCTIONAL ASSESSMENT; ACUPUNCTURE;
   RELIABILITY; VALIDITY; PAIN; NEUROTOXICITY; QUESTIONNAIRE; PACLITAXEL
AB Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a frequently-reported distress symptom in breast carcinoma patients under chemotherapy. Although previous studies emphasized lack of ideal neuroprotective or therapeutic agents for CIPN, there are no strongly recommended treatments. Nevertheless, auricular acupressure (AA) is a novel remedy for controlling symptoms in many healthcare settings. However, therapeutic effects of AA among patients with CIPN have not yet been elucidated fully. Therefore, we designed a trial to examine the effectiveness and safety of AA in breast cancer patients.
   Methods: This randomized, double-blind, sham-controlled trial will assess 120 breast cancer survivors. After enrollment, the participants will be stratified depending on administration of medications prescribed for CIPN treatment, and then assigned randomly to the experimental or control groups in an allocation ratio of 1:1. For experimental groups, AA will be applied on four points, namely, shemen, liver, spleen, and finger/ toe, while for the control groups, sham AA will be exerted on other four points that are remote from the treatment points and unrelated to neuropathic symptoms. All participants will undergo the same acupressure procedure, for two minutes each time, thrice daily for 3 weeks, and CIPN symptoms and health-related quality of life will be assessed by a blinded research assistant and a physician before, during, immediately after, and 4 weeks after AA. Occurrence, type, and severity of safety issues will be routinely monitored to confirm the non-toxic nature of AA. Repeated measures analysis of variance will be used to examine the changing pattern of CIPN symptoms and based on sensitivity analysis.
   Discussion: It is expected that the rationale and design of this protocol will offer knowledge regarding a standardized process to guide current and future studies and accumulates clinical experiences in applying non-pharmacological intervention. The present trial is the first to examine the therapeutic effects of AA in breast cancer patients with CIPN. The findings of the study may provide convincing evidence regarding the effectiveness of CIPN symptoms.
C1 [Jung, Mi Sook; Cha, Kyeongin; Dlamini, Nondumiso Satiso; Kim, Mijung] Chungnam Natl Univ, Coll Nursing, 266 Munhwa Ro, Daejeon 35015, South Korea.
   [Lee, Jin Sun] Chungnam Natl Univ, Coll Med, Dept Surg, Daejeon, South Korea.
   [Lee, Jin Sun] Chungnam Natl Univ, Coll Med, Res Inst Med Sci, Daejeon, South Korea.
   [Sohn, Eun Hee] Chungnam Natl Univ Hosp, Dept Neurol, Daejeon, South Korea.
C3 Chungnam National University; Chungnam National University; Chungnam
   National University; Chungnam National University; Chungnam National
   University Hospital
RP Kim, M (corresponding author), Chungnam Natl Univ, Coll Nursing, 266 Munhwa Ro, Daejeon 35015, South Korea.
EM cipnmj@gmail.com
RI Lee-Bitar, Jin Sun/ISS-9717-2023
FU National Research Foundation of Korea - Korea government
   [2017RA2B4004328]; Brain Korea 21 Plus project of the National Research
   Foundation of Korea Grant
FX MK was supported by the National Research Foundation of Korea grant
   funded by the Korea government (grant number: 2017RA2B4004328) and the
   Brain Korea 21 Plus project of the National Research Foundation of Korea
   Grant. This funding source will not have any role including design,
   execution analyses, interpretation of the data, and decision of this
   study.
CR Alimi D., 2002, MED ACUPUNCT, V13, P18
   [Anonymous], BMC COMPLEM ALTERN M
   [Anonymous], 2014, Auriculotherapy Manual: Chinese and Western Systems of Ear Acupuncture
   Argyriou AA, 2008, CRIT REV ONCOL HEMAT, V66, P218, DOI 10.1016/j.critrevonc.2008.01.008
   Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Bao T, 2016, BREAST CANCER RES TR, V159, P327, DOI 10.1007/s10549-016-3939-0
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Bhatnagar B, 2014, SPRINGERPLUS, V3, DOI 10.1186/2193-1801-3-366
   Bhide A, 2018, ACTA OBSTET GYN SCAN, V97, P380, DOI 10.1111/aogs.13309
   Carlson K, 2011, CLIN BREAST CANCER, V11, P73, DOI 10.1016/j.clbc.2011.03.006
   Cavaletti G, 2013, ANN ONCOL, V24, P454, DOI 10.1093/annonc/mds329
   Cavaletti G, 2003, NEUROLOGY, V61, P1297, DOI 10.1212/01.WNL.0000092015.03923.19
   Cavaletti G, 2007, J PERIPHER NERV SYST, V12, P210, DOI 10.1111/j.1529-8027.2007.00141.x
   CELLA DF, 1993, J CLIN ONCOL, V11, P570, DOI 10.1200/JCO.1993.11.3.570
   Colvin LA, 2019, PAIN, V160, pS1, DOI 10.1097/j.pain.0000000000001540
   Eckhoff L, 2015, EUR J CANCER, V51, P292, DOI 10.1016/j.ejca.2014.11.024
   Eghbali M, 2016, COMPLEMENT THER CLIN, V24, P189, DOI 10.1016/j.ctcp.2016.06.006
   Fradkin M, 2019, CURR MED CHEM, V26, P4698, DOI 10.2174/0929867326666190107163756
   Freund CL, 2004, J LAW MED ETHICS, V32, P106, DOI 10.1111/j.1748-720X.2004.tb00454.x
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Gornstein E, 2014, NEUROPHARMACOLOGY, V76, P175, DOI 10.1016/j.neuropharm.2013.08.016
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   He W, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/786839
   Henderson IC, 2003, J CLIN ONCOL, V21, P976, DOI 10.1200/JCO.2003.02.063
   Hershman DL, 2016, J CLIN ONCOL, V34, P3014, DOI 10.1200/JCO.2015.66.2346
   Hou PW, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/495684
   Huang CF, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016144
   Jensen MP, 2003, J PAIN, V4, P2, DOI 10.1054/jpai.2003.1
   Kavoussi B, 2007, INTEGR CANCER THER, V6, P251, DOI 10.1177/1534735407305892
   Kieffer JM, 2017, QUAL LIFE RES, V26, P2999, DOI 10.1007/s11136-017-1626-1
   Kim HY, 2014, J KOREAN ACAD NURS, V44, P735, DOI 10.4040/jkan.2014.44.6.735
   Kim M, 2020, J KOREAN ACAD FUNDAM, V27, P323
   Kim M, 2019, CANC NURS
   King HC, 2015, MIL MED, V180, P582, DOI 10.7205/MILMED-D-14-00451
   Kober A, 2003, ANESTHESIOLOGY, V98, P1328, DOI 10.1097/00000542-200306000-00005
   Li K, 2019, CURR ONCOL, V26, pE147, DOI 10.3747/co.26.4261
   Lu WD, 2013, CURR PAIN HEADACHE R, V17, DOI 10.1007/s11916-013-0321-3
   Nogier R, 2014, MED ACUPUNCT, V26, P76, DOI 10.1089/acu.2014.1035
   Oh PJ, 2018, J KOREAN ACAD NURS, V48, P123, DOI 10.4040/jkan.2018.48.2.123
   Paice JA, 1997, CANCER NURS, V20, P88, DOI 10.1097/00002820-199704000-00002
   Postma TJ, 2005, EUR J CANCER, V41, P1135, DOI 10.1016/j.ejca.2005.02.012
   Romoli M, 2014, NEUROL SCI, V35, pS189, DOI 10.1007/s10072-014-1768-7
   Samuels N, 2020, CURR ONCOL REP, V22, DOI 10.1007/s11912-020-0891-2
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Shin J, 2018, WESTERN J NURS RES, V40, P67, DOI 10.1177/0193945916680362
   Sparano JA, 2015, J CLIN ONCOL, V33, P2353, DOI 10.1200/JCO.2015.60.9271
   Staff NP, 2017, ANN NEUROL, V81, P772, DOI 10.1002/ana.24951
   Stubblefield MD, 2009, J NATL COMPR CANC NE, V7, pS1, DOI 10.6004/jnccn.2009.0078
   Sun Li-hong, 2015, Zhen Ci Yan Jiu, V40, P70
   Victorson D, 2008, QUAL LIFE RES, V17, P1137, DOI 10.1007/s11136-008-9398-2
   Weaver M T, 1985, Nurse Pract, V10, P38
   WinsteadFry P, 1997, CANCER, V79, P2446, DOI 10.1002/(SICI)1097-0142(19970615)79:12<2446::AID-CNCR23>3.0.CO;2-Q
   Xu SF, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/581203
   Yang Jin-Liang, 2014, Zhongguo Zhen Jiu, V34, P1165
   Yang LH, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/6383649
   Yeh Chao Hsing, 2020, Glob Adv Health Med, V9, p2164956120906092, DOI [10.1177/2164956120906092, 10.1177/2164956120906092]
   Yeh CH, 2019, PAIN MANAG NURS, V20, P623, DOI 10.1016/j.pmn.2019.04.004
   Yeh CH, 2019, PAIN MANAG NURS, V20, P614, DOI 10.1016/j.pmn.2019.04.005
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Zajaczkowska R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061451
   Zanville NR, 2016, SUPPORT CARE CANCER, V24, P4779, DOI 10.1007/s00520-016-3329-5
   Zhong Baoliang, 2009, J Thorac Dis, V1, P51
   Zhong Q, 2019, CHIN J INTEGR MED, V25, P225, DOI 10.1007/s11655-019-3063-1
NR 64
TC 3
Z9 4
U1 5
U2 31
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD JAN
PY 2021
VL 10
IS 1
BP 721
EP +
DI 10.21037/apm-20-1469
PG 13
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA QC0UM
UT WOS:000614549600077
PM 33440985
OA gold
DA 2026-01-16
ER

PT J
AU Zhang, JM
   Zhang, H
   Zheng, JF
   Niu, C
   Zhu, S
   Hu, HQ
   Lu, Y
   Zhu, MH
AF Zhang, Jiamin
   Zhang, Hao
   Zheng, Junfei
   Niu, Cong
   Zhu, Shu
   Hu, Haiqing
   Lu, Ye
   Zhu, Meihua
TI Safety and Effectiveness of Electroacupuncture During Colon Endoscopic
   Submucosal Dissection: A Randomized Controlled Trial
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE electroacupuncture; endoscopic submucosal dissection; propofol;
   remifentanil
ID ACUPUNCTURE; PAIN; DEXMEDETOMIDINE; SEDATION
AB Background: Endoscopic treatment of early colon neoplasms has evolved as a valid and less traumatic alternative to surgical resection. It can usually be performed with sedation on an outpatient basis. The present study was performed to determine the safety and effectiveness of electroacupuncture (EA) versus propofol sedation during endoscopic submucosal dissection (ESD) for early colon neoplasm. Methods: A total of 150 adult outpatients undergoing ESD were selected and divided into the EA combined with propofol group (EP group), remifentanil combined with propofol group (RP group), and propofol group (SP group), with 50 patients in each group. All patients received standard sedation with propofol. Acupuncture was performed before intravenous propofol injection in the EP group. A density wave of 1-3 mA, 2/100 hz current was administered for 20 min before the induction of anesthesia. The effectiveness of sedation was measured by satisfaction levels, and pain and sedation scores were measured by questionnaires. Respiratory and hemodynamic complications were monitored and compared as indices of safety. Results: Demographic data were comparable among the three groups. The total dose of propofol and the percentage of body movement in the EP group were lower than in the SP and RP groups (P<0.01). The incidence of hypotension and bradycardia in the SP and RP groups was higher than in the EP group. Patients who received the EA intervention showed a significant reduction in hypoxemia. The endoscopists felt that the procedure was more favorable in the EP group, but, there was no significant difference of patient satisfaction scores among three groups. Conclusion: Sedation with EA is effective and safe for patients undergoing ESD, and could improve the satisfaction levels of patients and gastroendoscopists.
C1 [Zhang, Jiamin; Zheng, Junfei; Niu, Cong; Zhu, Shu; Hu, Haiqing; Zhu, Meihua] Nanjing Univ Chinese Med, Affiliated Hosp 2, Dept Anesthesiol, Nanjing 210017, Jiangsu, Peoples R China.
   [Zhang, Hao] Nanjing Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Nanjing 210011, Peoples R China.
   [Lu, Ye] Nanjing Univ Chinese Med, Affiliated Hosp 2, Dept Surg, Nanjing 210017, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing Medical University;
   Nanjing University of Chinese Medicine
RP Zhu, MH (corresponding author), Nanjing Univ Chinese Med, Affiliated Hosp 2, Dept Anesthesiol, Nanjing 210017, Jiangsu, Peoples R China.; Lu, Y (corresponding author), Nanjing Univ Chinese Med, Affiliated Hosp 2, Dept Surg, Nanjing 210017, Jiangsu, Peoples R China.
EM zyyluyuanz@126.com; zhu_zmh@yeah.net
RI Meihua, Zhu/JFS-9423-2023
FU Science and Technology Project of Traditional Chinese Medicine
   Administration of Jiangsu Province [YB201822]
FX This work was supported by grants from the Science and Technology
   Project of Traditional Chinese Medicine Administration of Jiangsu
   Province (YB201822) .
CR Ashikari K, 2021, J GASTROEN HEPATOL, V36, P1920, DOI 10.1111/jgh.15417
   Bhatt A, 2020, GASTROINTEST ENDOSC, V92, P1187, DOI 10.1016/j.gie.2020.07.005
   Chen H, 2018, MED SCI MONITOR, V24, P2946, DOI 10.12659/MSM.909995
   Choi GH, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011215.pub2
   Cilli F, 2019, AM J INFECT CONTROL, V47, P582, DOI 10.1016/j.ajic.2018.10.014
   Eberl S, 2020, ACUPUNCT MED, V38, P131, DOI 10.1136/acupmed-2017-011459
   Ishihara R, 2020, DIGEST ENDOSC, V32, P452, DOI 10.1111/den.13654
   Gan CYJ, 2021, ANZ J SURG, V91, pE375, DOI 10.1111/ans.16870
   Kelly RB, 2019, AM FAM PHYSICIAN, V100, P89
   Kim JE, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003593
   Kim SH, 2022, J GASTROEN HEPATOL, V37, P558, DOI 10.1111/jgh.15718
   Lee Jun Kyu, 2017, Korean J Gastroenterol, V69, P55, DOI 10.4166/kjg.2017.69.1.55
   Lee S, 2023, THER ADV GASTROENTER, V16, DOI 10.1177/17562848231189957
   Lewis J, 2017, EUR J PAIN, V21, P1007, DOI 10.1002/ejp.1001
   Li QY, 2023, PAIN THER, V12, P1355, DOI 10.1007/s40122-023-00549-3
   Li QY, 2023, INTEGR CANCER THER, V22, DOI 10.1177/15347354231192017
   Li Y, 2019, J TRADIT CHIN MED, V39, P740
   Liao HY, 2017, SCI REP-UK, V7, DOI 10.1038/srep42531
   Lo MY, 2020, J FORMOS MED ASSOC, V119, P81, DOI 10.1016/j.jfma.2019.03.012
   Luo X, 2024, DRUG DES DEV THER, V18, P4551, DOI 10.2147/DDDT.S475749
   MacPherson Hugh, 2010, J Evid Based Med, V3, P140, DOI 10.1111/j.1756-5391.2010.01086.x
   Maselli R, 2019, DIGEST LIVER DIS, V51, P391, DOI 10.1016/j.dld.2018.09.023
   Nascimento FF, 2019, J VET MED SCI, V81, P764, DOI 10.1292/jvms.18-0744
   Sasaki T, 2013, DIGEST ENDOSC, V25, P79, DOI 10.1111/den.12024
   Schulz KF, 2010, ANN INTERN MED, V152, P726, DOI 10.7326/0003-4819-152-11-201006010-00232
   Seo SY, 2017, AM J CHINESE MED, V45, P1573, DOI 10.1142/S0192415X17500859
   Shetty GB, 2018, J ACUPUNCT MERIDIAN, V11, P153, DOI 10.1016/j.jams.2018.04.001
   Takeuchi Y, 2020, DIGESTION, V101, P450, DOI 10.1159/000500874
   Wan J, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030968
   Wang Q, 2024, MOL PAIN, V20, DOI 10.1177/17448069241254201
   Wu SY, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019541
   Yahagi N, 2022, DIGEST ENDOSC, V34, P95, DOI 10.1111/den.14229
   Yang GZ, 2017, J ANESTH, V31, P156, DOI 10.1007/s00540-016-2258-2
   Ye EC, 2023, BRIT J CLIN PHARMACO, V89, P3401, DOI 10.1111/bcp.15839
NR 34
TC 0
Z9 0
U1 1
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2025
VL 18
BP 1221
EP 1229
DI 10.2147/JPR.S501941
PG 9
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 0CW2T
UT WOS:001444351600001
PM 40104825
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Kim, TH
   Kang, JW
   Lee, TH
AF Kim, Tae-Hun
   Kang, Jung Won
   Lee, Tae Hee
TI Therapeutic options for aromatase inhibitor-associated arthralgia in
   breast cancer survivors: A systematic review of systematic reviews,
   evidence mapping, and network meta-analysis
SO MATURITAS
LA English
DT Review
DE Scoping study; Overview of systematic reviews; Network meta-analysis;
   Aromatase inhibitor-associated arthralgia; Acupuncture
ID INDUCED MUSCULOSKELETAL SYMPTOMS; ACUPUNCTURE; TRIAL; MANAGEMENT;
   ESTROGEN; ELECTROACUPUNCTURE; WOMEN
AB Aromatase inhibitor-associated arthralgia (AIA) is a common problem in breast cancer survivors and is associated with noncompliance with aromatase inhibitor therapy. The aim of this research was to assess the current evidence for the various therapeutic options available for AIA. We searched the PubMed, EMBASE, Cochrane Database of Systematic Reviews, and Database of Abstracts of Reviews of Effects for systematic reviews of trials investigating treatments for AIA to June 2018. Eligible systematic reviews were subjected to evidence mapping and the randomized controlled trials included in the systematic reviews were hand-searched for a network meta analysis. Six systematic reviews were included in the evidence mapping. Acupuncture was the most common treatment modality studied (four randomized controlled trials), and pharmacological interventions, aerobic exercise, Nordic walking, omega-3 fatty acids, and vitamin D were assessed less frequently. In view of the limitations in the overall confidence level for each review, the evidence for acupuncture as an effective treatment for AIA was considered low. Second, data from 6 randomized controlled trials were included in the network meta-analysis. When compared with a waiting list control, acupuncture (mean difference [MD] -2.00, 95% confidence interval [CI] -3.16, -0.84), aerobic exercise (MD -0.80, 95% CI-1.33, -0.016), and omega-3 fatty acids (MD -2.10, 95% CI -3.23, -0.97) significantly improved pain severity scores. Network meta-analysis of adverse events was not possible because of poor reporting. Acupuncture is presently the most widely investigated intervention but is recommended for MA with low overall confidence based on the current evidence.
C1 [Kim, Tae-Hun] Kyung Hee Univ, Korean Med Hosp, Korean Med Clin Trial Ctr, 23 Kyungheedae Ro, Seoul 130872, South Korea.
   [Kang, Jung Won] Kyung Hee Univ, Coll Korean Med, Dept Acupuncture & Moxibust, 23 Kyungheedae Ro, Seoul 130872, South Korea.
   [Lee, Tae Hee] Gachon Univ, Coll Korean Med, Dept Formulae Pharmacol, Seong Nam, South Korea.
C3 Kyung Hee University; Kyung Hee University Hospital; Kyung Hee
   University; Gachon University
RP Kim, TH (corresponding author), Kyung Hee Univ, Korean Med Hosp, Korean Med Clin Trial Ctr, 23 Kyungheedae Ro, Seoul 130872, South Korea.
EM taehunkim@khu.ac.kr
RI Kim, Tae-Hun/G-8728-2014
OI Kim, Tae-Hun/0000-0002-8448-3219
FU Korea Institute of Oriental Medicine in Republic of Korea [K18122]
FX This research was funded by the Korea Institute of Oriental Medicine in
   Republic of Korea (Grant ID: K18122).
CR Anderson Stuart, 2008, Health Res Policy Syst, V6, P7, DOI 10.1186/1478-4505-6-7
   [Anonymous], 2014, Evidence map of acupuncture
   Bae K, 2015, INTEGR CANCER THER, V14, P496, DOI 10.1177/1534735415596573
   Beckwée D, 2017, SUPPORT CARE CANCER, V25, P1673, DOI 10.1007/s00520-017-3613-z
   BUCHANAN JR, 1986, CALCIFIED TISSUE INT, V39, P139, DOI 10.1007/BF02555109
   Burstein HJ, 2007, J CLIN ONCOL, V25, DOI 10.1200/JCO.2007.11.9529
   Burstein HJ, 2007, BREAST, V16, P223, DOI 10.1016/j.breast.2007.01.011
   Burstein HJ, 2010, J CLIN ONCOL, V28, P3784, DOI 10.1200/JOP.000082
   Chen L, 2017, BREAST, V33, P132, DOI 10.1016/j.breast.2017.03.015
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Cipriani A, 2013, ANN INTERN MED, V159, P130, DOI 10.7326/0003-4819-159-2-201307160-00008
   CLELAND LG, 1988, J RHEUMATOL, V15, P1471
   Coleman RE, 2008, CANCER TREAT REV, V34, P275, DOI 10.1016/j.ctrv.2007.10.004
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Dawson-Basoa M, 1998, BRAIN RES, V794, P61, DOI 10.1016/S0006-8993(98)00192-9
   Fields J., 2015, A feasibility study of a Nordic walking intervention for women experiencing aromatase inhibitor associated arthralgia
   Gibson L., 2009, COCHRANE DB SYST REV, V4
   Ho SC, 1999, MATURITAS, V33, P219, DOI 10.1016/S0378-5122(99)00056-0
   Irwin ML, 2015, J CLIN ONCOL, V33, P1104, DOI 10.1200/JCO.2014.57.1547
   Islander U, 2011, MOL CELL ENDOCRINOL, V335, P14, DOI 10.1016/j.mce.2010.05.018
   Lin JG, 2008, AM J CHINESE MED, V36, P635, DOI 10.1142/S0192415X08006107
   Lustberg MB, 2018, BREAST CANCER RES TR, V167, P709, DOI 10.1007/s10549-017-4559-z
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Nahm N, 2018, ASIA-PAC J CLIN ONCO, V14, P374, DOI 10.1111/ajco.12845
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Oestergaard S, 2006, ARTHRITIS RHEUM-US, V54, P2441, DOI 10.1002/art.22009
   Petersen AMW, 2005, J APPL PHYSIOL, V98, P1154, DOI 10.1152/japplphysiol.00164.2004
   Rastelli AL, 2011, BREAST CANCER RES TR, V129, P107, DOI 10.1007/s10549-011-1644-6
   Reinbolt RE, 2018, CANCER MED-US, V7, P240, DOI 10.1002/cam4.1256
   Roberts K, 2017, CRIT REV ONCOL HEMAT, V111, P66, DOI 10.1016/j.critrevonc.2017.01.010
   Salanti G, 2008, STAT METHODS MED RES, V17, P279, DOI 10.1177/0962280207080643
   Schaible HG, 2010, ANN NY ACAD SCI, V1193, P60, DOI 10.1111/j.1749-6632.2009.05301.x
   Shea BJ, 2017, BMJ-BRIT MED J, V358, DOI 10.1136/bmj.j4008
   Shim S, 2017, EPIDEMIOL HEALTH, V39, DOI 10.4178/epih.e2017047
   Vaananen HK, 1996, MATURITAS, V23, pS65
   White IR, 2015, STATA J, V15, P951, DOI 10.1177/1536867X1501500403
   Yang GS, 2017, CANCER NURS, V40, pE26, DOI 10.1097/NCC.0000000000000409
NR 38
TC 23
Z9 29
U1 0
U2 24
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD DEC
PY 2018
VL 118
BP 29
EP 37
DI 10.1016/j.maturitas.2018.09.005
PG 9
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA HC2TD
UT WOS:000451653900005
PM 30415752
DA 2026-01-16
ER

PT J
AU Li, HJ
   Schlaeger, JM
   Jang, MK
   Lin, YF
   Park, C
   Liu, TT
   Sun, M
   Doorenbos, AZ
AF Li, Hongjin
   Schlaeger, Judith M.
   Jang, Min Kyeong
   Lin, Yufen
   Park, Chang
   Liu, Tingting
   Sun, Min
   Doorenbos, Ardith Z.
TI Acupuncture Improves Multiple Treatment-Related Symptoms in Breast
   Cancer Survivors: A Systematic Review and Meta-Analysis
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review
DE acupuncture; breast cancer; meta-analysis; symptom; symptom cluster
ID INHIBITOR-RELATED ARTHRALGIA; HOT FLASHES; CONTROLLED-TRIAL;
   DOUBLE-BLIND; ALTERNATIVE MEDICINE; SLEEP DISTURBANCES; VASOMOTOR
   SYMPTOMS; HORMONE-THERAPY; PLACEBO NEEDLE; DUAL-CENTER
AB Introduction: Acupuncture has demonstrated effectiveness for symptom management among breast cancer survivors. This meta-analysis aims to evaluate the effect of acupuncture on treatment-related symptoms among breast cancer survivors. Methods: The authors searched PubMed, CINAHL, and EMBASE for relevant randomized clinical trials (RCTs) of acupuncture for managing treatment-related symptoms published in English through June 2021. They appraised the quality of each article using the Cochrane Collaboration Risk of Bias Criteria. The primary outcomes were pain, hot flashes, sleep disturbance, fatigue, depression, lymphedema, and neuropathy as individual symptoms. They also evaluated adverse events reported in acupuncture studies. Results: Of 26 selected trials (2055 patients), 20 (1709 patients) were included in the meta-analysis. Acupuncture was more effective than control groups in improving pain intensity [standardized mean difference (SMD) = -0.60, 95% confidence intervals (CI) -1.06 to -0.15], fatigue [SMD = -0.62, 95% CI -1.03 to -0.20], and hot flash severity [SMD = -0.52, 95% CI -0.82 to -0.22]. The subgroup analysis indicated that acupuncture showed trends but not significant effects on all the treatment-related symptoms compared with the sham acupuncture groups. Compared with waitlist control and usual care groups, the acupuncture groups showed significant reductions in pain intensity, fatigue, depression, hot flash severity, and neuropathy. No serious adverse events were reported related to acupuncture intervention. Mild adverse events (i.e., bruising, pain, swelling, skin infection, hematoma, headache, menstrual bleeding) were reported in 11 studies. Conclusion: This systematic review and meta-analysis suggest that acupuncture significantly reduces multiple treatment-related symptoms compared with the usual care or waitlist control group among breast cancer survivors. The safety of acupuncture was inadequately reported in the included studies. Based on the available data, acupuncture seems to be generally a safe treatment with some mild adverse events. These findings provide evidence-based recommendations for incorporating acupuncture into clinical breast cancer symptom management. Due to the high risk of bias and blinding issues in some RCTs, more rigorous trials are needed to confirm the efficacy of acupuncture in reducing multiple treatment-related symptoms among breast cancer survivors.
C1 [Li, Hongjin; Schlaeger, Judith M.] Univ Illinois, Coll Nursing, Dept Human Dev Nursing Sci, 845 S Damen Ave,MC 802, Chicago, IL 60612 USA.
   [Li, Hongjin; Jang, Min Kyeong; Doorenbos, Ardith Z.] Univ Illinois, Dept Canc Prevent & Control, Canc Ctr, Chicago, IL 60612 USA.
   [Jang, Min Kyeong; Doorenbos, Ardith Z.] Univ Illinois, Coll Nursing, Dept Biobehav Nursing Sci, Chicago, IL 60612 USA.
   [Lin, Yufen] Emory Univ, Sch Nursing, Atlanta, GA 30322 USA.
   [Park, Chang] Univ Illinois, Coll Nursing, Dept Populat Hlth Nursing Sci, Chicago, IL 60612 USA.
   [Liu, Tingting] Univ Arkansas, Eleanor Mann Sch Nursing, Little Rock, AR 72204 USA.
   [Sun, Min] Univ Pittsburgh, Sch Med, Hillman Canc Ctr, Dept Hematol & Oncol, Pittsburgh, PA USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; Emory University; University of
   Illinois System; University of Illinois Chicago; University of Illinois
   Chicago Hospital; University of Arkansas System; University of Arkansas
   Little Rock; University of Arkansas Fayetteville; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Li, HJ (corresponding author), Univ Illinois, Coll Nursing, Dept Human Dev Nursing Sci, 845 S Damen Ave,MC 802, Chicago, IL 60612 USA.
EM hongjin@uic.edu
RI schlaeger, judith/N-4482-2017; Lin, Yufen/JOJ-6428-2023; Jang, Min
   Kyeong/GLR-2888-2022; Liu, Tingting/S-3995-2016; Park,
   Chang/AEN-4164-2022
OI Lin, Yufen/0000-0002-9182-2928; Jang, Min Kyeong/0000-0002-6073-161X;
   Sun, Min/0000-0001-9792-6798; Li, Hongjin/0000-0002-5466-1192; 
FU National Institute of Nursing Research of the National Institutes of
   Health [K24NR015340]
FX This work was supported by the National Institute of Nursing Research of
   the National Institutes of Health (award no. K24NR015340).
CR Bao T, 2018, BREAST CANCER RES TR, V170, P77, DOI 10.1007/s10549-018-4743-9
   Bao T, 2014, CANCER-AM CANCER SOC, V120, P381, DOI 10.1002/cncr.28352
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Bell Iris R, 2004, BMC Complement Altern Med, V4, P1, DOI 10.1186/1472-6882-4-1
   Biglia N, 2012, EUR J CANCER CARE, V21, P485, DOI 10.1111/j.1365-2354.2011.01320.x
   Birch S, 2019, INTEGR MED RES, V8, P33, DOI 10.1016/j.imr.2018.07.005
   Bokmand S, 2013, BREAST, V22, P320, DOI 10.1016/j.breast.2012.07.015
   Brauer JA, 2010, J ALTERN COMPLEM MED, V16, P183, DOI 10.1089/acm.2009.0354
   Chen L, 2017, BREAST, V33, P132, DOI 10.1016/j.breast.2017.03.015
   Chien TJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180918
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Deng G, 2007, J CLIN ONCOL, V25, P5584, DOI 10.1200/JCO.2007.12.0774
   Deng G, 2013, SUPPORT CARE CANCER, V21, P1735, DOI 10.1007/s00520-013-1720-z
   Frisk J, 2008, CLIMACTERIC, V11, P166, DOI 10.1080/13697130801958709
   Frisk J, 2012, SUPPORT CARE CANCER, V20, P715, DOI 10.1007/s00520-011-1134-8
   Garland SN, 2017, MENOPAUSE, V24, P517, DOI 10.1097/GME.0000000000000779
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Haque R, 2016, JNCI-J NATL CANCER I, V108, DOI 10.1093/jnci/djv337
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hervik J, 2009, BREAST CANCER RES TR, V116, P311, DOI 10.1007/s10549-008-0210-3
   Higgins Julian P T, 2011, BMJ, V343, pd5928, DOI 10.1136/bmj.d5928
   Hu H., 2016, EVIDENCE BASED RES M, P55, DOI DOI 10.1007/978-981-10-2290-64
   Jia LB, 2012, CHIN J INTEGR MED, V18, P325, DOI 10.1007/s11655-011-0950-5
   Kim HJ, 2008, J PAIN SYMPTOM MANAG, V36, P468, DOI 10.1016/j.jpainsymman.2007.11.011
   Kim JEE, 2009, J PAIN SYMPTOM MANAG, V37, P715, DOI 10.1016/j.jpainsymman.2008.04.018
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Li HJ, 2020, J PAIN SYMPTOM MANAG, V59, P233, DOI 10.1016/j.jpainsymman.2019.10.002
   Liberati Alessandro, 2009, PLoS Med, V6, pe1000100, DOI 10.1371/journal.pmed.1000100
   Liljegren A, 2012, BREAST CANCER RES TR, V135, P791, DOI 10.1007/s10549-010-1283-3
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Lupo Molly, 2015, J Adv Pract Oncol, V6, P322, DOI 10.6004/jadpro.2015.6.4.3
   Mao JJ, 2015, J CLIN ONCOL, V33, P3615, DOI 10.1200/JCO.2015.60.9412
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Moeyaert M, 2017, INT J SOC RES METHOD, V20, P559, DOI 10.1080/13645579.2016.1252189
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   National Center for Complementary and Integrative Health (NCCIH), 2020, NATL HLTH INTERVIEW
   Nedstrand E, 2006, J PSYCHOSOM OBST GYN, V27, P193, DOI 10.1080/01674820600724797
   Ng CG, 2015, HEALTH QUAL LIFE OUT, V13, DOI 10.1186/s12955-015-0401-7
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Otte JL, 2011, CLIN NURSE SPEC, V25, P228, DOI 10.1097/NUR.0b013e318229950b
   Paley CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub3
   Pan YQ, 2018, INTEGR CANCER THER, V17, P602, DOI 10.1177/1534735418786801
   RevMan, 2014, REV MAN REVMAN COMP
   Salehi A, 2016, SUPPORT CARE CANCER, V24, P4895, DOI 10.1007/s00520-016-3345-5
   Salomon RE, 2020, NURS RES, V69, P133, DOI 10.1097/NNR.0000000000000412
   Siotos C., 2020, COCHRANE DB SYST REV
   Smith C, 2013, ACUPUNCT MED, V31, P9, DOI 10.1136/acupmed-2012-010228
   Smith CA, 2014, ACUPUNCT MED, V32, P387, DOI 10.1136/acupmed-2014-010593
   Streitberger K, 1998, LANCET, V352, P364, DOI 10.1016/S0140-6736(97)10471-8
   Sullivan CW, 2018, J PAIN SYMPTOM MANAG, V55, P39, DOI 10.1016/j.jpainsymman.2017.08.008
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Takakura N, 2018, ANAESTHESIA, V73, P258, DOI 10.1111/anae.14208
   Takakura N., 2013, ISRN PAIN, DOI DOI 10.1155/2013/825751
   Takakura N, 2011, ACUPUNCT MED, V29, P203, DOI 10.1136/aim.2010.002857
   Takakura Nobuari, 2007, BMC Complement Altern Med, V7, P31, DOI 10.1186/1472-6882-7-31
   Tavel ME, 2014, AM J MED, V127, P484, DOI 10.1016/j.amjmed.2014.02.002
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   Yao C, 2016, CURR ONCOL, V23, pE27, DOI 10.3747/co.23.2788
   Yoo TK, 2018, J BREAST CANCER, V21, P37, DOI 10.4048/jbc.2018.21.1.37
   Zhang XY, 2019, ACUPUNCT MED, V37, P16, DOI 10.1136/acupmed-2018-011668
   Zhou W, 2014, J ACUPUNCT MERIDIAN, V7, P190
   Zhu D, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/628907
   Zhuo Lian-Shi, 2011, Zhongguo Zhen Jiu, V31, P75
NR 67
TC 30
Z9 36
U1 2
U2 29
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD DEC 1
PY 2021
VL 27
IS 12
BP 1084
EP 1097
DI 10.1089/acm.2021.0133
EA AUG 2021
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA XL2VJ
UT WOS:000690379700001
PM 34449251
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Wang, YY
   Li, XY
   Ji, XP
   Wu, J
   Li, JX
   Zheng, W
   Wu, CQ
   Huang, L
   Geng, ZH
   Zhou, J
AF Wang, Yuyan
   Li, Xinyu
   Ji, Xiaopeng
   Wu, Jing
   Li, Junxin
   Zheng, Wei
   Wu, Caiqin
   Huang, Lan
   Geng, Zhaohui
   Zhou, Jie
TI Adaptive Auricular Point Acupressure for Sleep Disturbance in Women with
   Breast Cancer: A Randomized Controlled Trial
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID QUALITY-OF-LIFE; SINGLE-BLIND; ACUPUNCTURE; INSOMNIA; PAIN;
   CHEMOTHERAPY; ACTIGRAPHY; SYMPTOMS; THERAPY; FATIGUE
AB Objectives. The study aimed to evaluate the preliminary effect and efficacy of auricular point acupressure (APA) on the quality of sleep in women with breast cancer who were undergoing chemotherapy. Sample & Setting. We conducted a randomized controlled trial on 68 patients with breast cancer who reported poor sleep quality based on the Pittsburgh Sleep Quality Index (PSQI) scores (>7). Methods & Variables. Participants were randomly assigned to an APA treatment group or a control group. Patients in the APA group had magnetic pellets attached to selected auricular points and were instructed to apply pressure to these points 4x/day for three consecutive weeks. We objectively measured sleep quality using the Actiwatch Spectrum and the PSQI at the baseline and postintervention. Statistical analyses of changes in sleep data were performed using the t-test, a rank-sum test, and analyses of covariance. Results. In patients treated with APA, the PSQI total score and sleep onset latency had significantly decreased, while the total sleep time and sleep efficiency had significantly increased. Although the total PSQI score differed between groups at the baseline, ANCOVA results showed that the APA group had a significantly lower total PSQI score. Conclusion. APA could be an inexpensive and effective approach to improving sleep quality and reducing sleep disturbance in patients with breast cancer. Further research needs a larger sample size to verify our findings.
C1 [Wang, Yuyan; Li, Xinyu; Wu, Jing; Wu, Caiqin; Huang, Lan; Geng, Zhaohui; Zhou, Jie] Shanghai Univ Tradit Chinese Med, Sch Nursing, Shanghai, Peoples R China.
   [Ji, Xiaopeng] Univ Delaware, Sch Nursing, Newark, DE USA.
   [Li, Junxin] Johns Hopkins Univ, Sch Nursing, Baltimore, MD USA.
   [Zheng, Wei] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; University of
   Delaware; Johns Hopkins University; Shanghai University of Traditional
   Chinese Medicine
RP Geng, ZH; Zhou, J (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Nursing, Shanghai, Peoples R China.
EM gengzh200890@163.com; zhoujieshutcmpaper@163.com
RI ; Wu, Caiqin/ACO-7450-2022; Zheng, Wei/O-3351-2013
OI Ji, Xiaopeng/0000-0002-6977-3883; Li, Xinyu/0000-0003-3433-3009; 
FU Humanities and Social Science Research Project of Ministry of Education;
   National Natural Science Foundation of China; Shanghai Science and
   Technology Innovation Action Plan Sailing Project;  [21YJCZH032]; 
   [72104145];  [21YF1447700]
FX AcknowledgmentsThe study was supported by the Humanities and Social
   Science Research Project of Ministry of Education (No. 21YJCZH032), the
   National Natural Science Foundation of China (No. 72104145), and the
   Shanghai Science and Technology Innovation Action Plan Sailing Project
   (No. 21YF1447700).
CR Aasm A.A.O.S., 2014, INT CLASSIFICATION S, V3
   Afrasiabian F, 2019, PHYTOTHER RES, V33, P350, DOI 10.1002/ptr.6228
   [Anonymous], 2011, Journal of Acupuncture and Tuina Science, DOI DOI 10.1007/S11726-011-0557-6
   [Anonymous], 2005, Auricular Medicine: A Complete Manual of Auricular Diagnosis and Treatment
   Barsevick A, 2010, J PAIN SYMPTOM MANAG, V40, P200, DOI 10.1016/j.jpainsymman.2009.12.020
   Bower JE, 2012, CANCER-AM CANCER SOC, V118, P3766, DOI 10.1002/cncr.26702
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1002/smll.202408771
   Chaoul A, 2018, CANCER-AM CANCER SOC, V124, P36, DOI 10.1002/cncr.30938
   Chueh KH, 2018, J NURS RES, V26, P10, DOI 10.1097/JNR.0000000000000209
   Costa AR, 2014, BREAST, V23, P697, DOI 10.1016/j.breast.2014.09.003
   Feng C.X., 1994, Chinese Auricular Therapy
   Garner BK, 2018, MED ACUPUNCT, V30, P262, DOI 10.1089/acu.2018.1294
   Gori L, 2007, EVID-BASED COMPL ALT, V4, P13, DOI 10.1093/ecam/nem106
   Harding C, 2009, BJU INT, V103, P186, DOI 10.1111/j.1464-410X.2008.07884.x
   Innominato PF, 2015, SLEEP MED, V16, P391, DOI 10.1016/j.sleep.2014.10.022
   Ko YL, 2016, J CLIN NURS, V25, P332, DOI 10.1111/jocn.13053
   Kuo HC, 2018, RES NURS HEALTH, V41, P469, DOI 10.1002/nur.21885
   Lan Y, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0606-7
   Lee MS, 2008, INT J CLIN PRACT, V62, P1744, DOI 10.1111/j.1742-1241.2008.01876.x
   Lees J, 2011, LANCET ONCOL, V12, P1249, DOI 10.1016/S1470-2045(11)70040-7
   Li MK, 2014, COMPLEMENT THER MED, V22, P266, DOI 10.1016/j.ctim.2014.01.010
   Lin WC, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/103570
   Liu XC., 1996, Chin. J. Psychiatry, V29, P103
   Lo C, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/530438
   Lua PL, 2013, ALTERN THER HEALTH M, V19, P28
   Macciò A, 2012, CYTOKINE, V58, P133, DOI 10.1016/j.cyto.2012.01.015
   Matthews EE, 2013, SLEEP MED REV, V17, P453, DOI 10.1016/j.smrv.2013.01.001
   Ng JY, 2021, BMC COMPLEMENT MED, V21, DOI 10.1186/s12906-021-03223-3
   Nogier P., 1981, HDB AURICULOTHERAPY
   Oleson T., 2013, Auriculotherapy manual: Chinese and Western Systems of Ear Acupuncture
   Palesh O, 2017, QUAL LIFE RES, V26, P2783, DOI 10.1007/s11136-017-1617-2
   Palesh O, 2013, J NATL COMPR CANC NE, V11, P1523, DOI 10.6004/jnccn.2013.0179
   Prisco MK, 2013, MED ACUPUNCT, V25, P407, DOI 10.1089/acu.2013.0989
   Qaseem A, 2016, ANN INTERN MED, V165, P125, DOI 10.7326/M15-2175
   Qz Z., 1986, SHANXI J TRADITIONAL, V2, P38
   Rahmani A, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/2753294
   Rusch HL, 2019, ANN NY ACAD SCI, V1445, P5, DOI 10.1111/nyas.13996
   Sadeh A, 2011, SLEEP MED REV, V15, P259, DOI 10.1016/j.smrv.2010.10.001
   Sadler P, 2018, SLEEP, V41, DOI 10.1093/sleep/zsy104
   Savard J, 2012, PSYCHO-ONCOLOGY, V21, P37
   Spence DW, 2004, J NEUROPSYCH CLIN N, V16, P19, DOI 10.1176/appi.neuropsych.16.1.19
   Suen L K, 2001, Complement Ther Nurs Midwifery, V7, P132, DOI 10.1054/ctnm.2001.0565
   Tan JY, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/506758
   Usichenko TI, 2007, CAN MED ASSOC J, V176, P179, DOI 10.1503/cmaj.060875
   Vas J, 2014, ACUPUNCT MED, V32, P227, DOI 10.1136/acupmed-2013-010507
   Wan C., 1991, CHINESE MENTAL HLTH, V05
   Wan XP, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/1334255
   Wang SM, 2001, ANESTH ANALG, V93, P1178, DOI 10.1097/00000539-200111000-00024
   WASHBURN AM, 1993, J SUBST ABUSE TREAT, V10, P345, DOI 10.1016/0740-5472(93)90019-X
   Yeh CH., 2014, J Pain Relief, DOI DOI 10.4172/2167-0846.1000139
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Yeung WF, 2012, SLEEP MED, V13, P971, DOI 10.1016/j.sleep.2012.06.003
   Yoon HG, 2019, APPL NURS RES, V48, P45, DOI 10.1016/j.apnr.2019.05.009
   Yuanyuan Y., 2015, J NURSING SCI, V5
   Zou C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122724
NR 55
TC 18
Z9 19
U1 2
U2 31
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD OCT 31
PY 2022
VL 2022
AR 8637386
DI 10.1155/2022/8637386
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 6G8IV
UT WOS:000884994700001
PM 36353150
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Relf, IRN
   Brahmanand, T
AF Relf, Ian R. N.
   Brahmanand, Tanishka
TI Reductions in Chronic Postsurgical Neuropathic Pain and Mechanical
   Allodynia in Breast Cancer Patients Treated With Laser Acupuncture: A
   Retrospective Observational Study
SO CLINICAL BREAST CANCER
LA English
DT Article
DE Breast cancer surgery (BCS); Chronic postsurgical pain; Embryology;
   Neuropathic pain; Static mechanical allodynia (SMA)
ID DOUBLE-BLIND; OSTEOARTHRITIS; KNEE
AB Neuropathic or burning pain is very difficult to treat and is present in 40% of cancer patients. Thirty breast cancer patients with severe burning pain after surgery were treated with a new laser acupuncture technique and their pain was reduced by more than 70%. This may be a viable treatment for breast cancer patients left with severe pain after surgery. Introduction: Chronic postsurgical neuropathic pain (CPSNP) and related static mechanical allodynia (SMA) is recognised as a significant long-term complication after breast cancer surgery (BCS). This study investigates the effectiveness of a novel laser acupuncture technique in treating CPSNP and SMA post-BCS whilst patients underwent standard cancer treatments. Methods: Thirty patients with significant breast area CPSNP and SMA (DN4 >= 4) were treated with 60Milliwatt, 658nm laser acupuncture at Austin Hospital between January 2021 and 2024. Patient data was analysed retrospectively: 29 with CPSNP, 22 with SMA. The cohort had exposures to pain aggravating cancer therapies (e.g. chemotherapy, radiotherapy and antihormonal medications). An online patient questionnaire assessed treatment outcomes qualitatively. Results: Patients received an average of 6 <middle dot> 4 treatments and their average CPSNP showed significant reduction from 6 <middle dot> 86 to 1.29 ( P < .001), with a mean 5.57 point decrease (95% CI, 4.90-6.24). Average SMA showed significant reduction from an average of 6.77-1.75 ( P < .001), with a mean 5.02-point decrease (95% CI, 4.09-5.96). Pain reductions occurred despite NP aggravating treatment and ongoing usage by 40% of the cohort. 92% of patients reported acute reductions in SMA in the online questionnaire. Conclusion: The significant pain reductions observed may indicate effectiveness of laser acupuncture in reducing both CPSNP and SMA in breast cancer patients post-BCS.
C1 [Relf, Ian R. N.] Austin Hosp, Olivia Newton John Canc & Wellness Ctr, Melbourne, Vic, Australia.
   [Brahmanand, Tanishka] Univ Melbourne, Austin Hosp, Clin Sch, Dept Med, Melbourne, Vic, Australia.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Olivia Newton-John Cancer & Wellness Centre;
   Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; University of Melbourne
RP Relf, IRN (corresponding author), Austin Hosp, Olivia Newton John Canc & Wellness Ctr, Melbourne, Vic, Australia.
EM Ian.RELF@austin.org.au
OI Relf, Ian/0000-0002-9708-5906
CR Asmussen S, 2019, J INTENSIVE CARE MED, V34, P652, DOI 10.1177/0885066617708558
   Baeumler PI, 2015, PAIN, V156, P2245, DOI 10.1097/j.pain.0000000000000283
   Baeumler PI, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113731
   Bajrovic A, 2004, RADIOTHER ONCOL, V71, P297, DOI 10.1016/j.radonc.2004.03.005
   Bennett MI, 2012, PAIN, V153, P359, DOI 10.1016/j.pain.2011.10.028
   Berman BM, 2004, ANN INTERN MED, V141, P901, DOI 10.7326/0003-4819-141-12-200412210-00006
   Bethea JR, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.641588
   Brinkhaus B, 2006, ARCH INTERN MED, V166, P450
   Chow R, 2011, PHOTOMED LASER SURG, V29, P365, DOI 10.1089/pho.2010.2928
   Chow RT, 2009, LANCET, V374, P1897, DOI 10.1016/S0140-6736(09)61522-1
   Corcoran TB, 2023, BRIT J ANAESTH, V131, P93, DOI 10.1016/j.bja.2023.03.031
   Dorsher PT, 2017, MED ACUPUNCT, V29, P10, DOI 10.1089/acu.2016.1210
   Finnerup NB, 2015, LANCET NEUROL, V14, P162, DOI 10.1016/S1474-4422(14)70251-0
   Gottschling S, 2008, PAIN, V137, P405, DOI 10.1016/j.pain.2007.10.004
   Grisold W, 2012, NEURO-ONCOLOGY, V14, P45, DOI 10.1093/neuonc/nos203
   Haake M, 2007, ARCH INTERN MED, V167, P1892, DOI 10.1001/archinte.167.17.1892
   Jena S, 2008, CEPHALALGIA, V28, P969, DOI 10.1111/j.1468-2982.2008.01640.x
   Kang C, 2020, PAIN PHYSICIAN, V23, P37, DOI 10.36076/ppj.2020/23/37
   Lin GH, 2020, J ZHEJIANG UNIV-SC B, V21, P757, DOI 10.1631/jzus.B2000285
   Liu XM, 2021, INTEGR CANCER THER, V20, DOI 10.1177/1534735420980811
   Macdonald L, 2005, BRIT J CANCER, V92, P225, DOI 10.1038/sj.bjc.6602304
   MacPherson H, 2017, PAIN, V158, P784, DOI 10.1097/j.pain.0000000000000747
   Mathieson S, 2015, J CLIN EPIDEMIOL, V68, P957, DOI 10.1016/j.jclinepi.2015.03.010
   Molsberger AF, 2010, PAIN, V151, P146, DOI 10.1016/j.pain.2010.06.036
   Moore RA, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007938.pub3
   Mustonen L, 2020, SCAND J PAIN, V20, P683, DOI 10.1515/sjpain-2020-0013
   Mustonen L, 2019, PAIN, V160, P246, DOI 10.1097/j.pain.0000000000001398
   Prudhomme M, 2020, J VISC SURG, V157, P43, DOI 10.1016/j.jviscsurg.2019.09.004
   Rapson LM, 2003, J SPINAL CORD MED, V26, P21, DOI 10.1080/10790268.2003.11753655
   Sun C, 2023, FRONT ONCOL, V13, DOI 10.3389/fonc.2023.1096468
   Truini A, 2013, NAT REV NEUROL, V9, P572, DOI 10.1038/nrneurol.2013.180
   Velayudhan A, 2014, BJA EDUC, V14, P125, DOI 10.1093/bjaceaccp/mkt045
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Witt C, 2005, LANCET, V366, P136, DOI 10.1016/S0140-6736(05)66871-7
   Yin ZH, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/3178154
   Zhao ZJ, 2021, INT J CLIN PRACT, V75, DOI 10.1111/ijcp.15010
NR 36
TC 4
Z9 5
U1 0
U2 2
PU CIG MEDIA GROUP, LP
PI DALLAS
PA 3500 MAPLE AVENUE, STE 750, DALLAS, TX 75219-3931 USA
SN 1526-8209
EI 1938-0666
J9 CLIN BREAST CANCER
JI Clin. Breast Cancer
PD DEC
PY 2024
VL 24
IS 8
BP 763
EP 770
DI 10.1016/j.clbc.2024.09.005
EA NOV 2024
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA O1C6W
UT WOS:001368595000001
PM 39426907
DA 2026-01-16
ER

PT J
AU Sun, XY
   Lu, LY
   Wang, YQ
   Wang, CC
   Lin, C
   Xu, KD
   Yong, Y
   Chen, WT
   Song, JA
AF Sun, Xiangyu
   Lu, Liyue
   Wang, Yongqiang
   Wang, Chunchun
   Lin, Chao
   Xu, Kuangdi
   Yong, Yue
   Chen, Wenting
   Song, Jiangang
TI Effect of electroacupuncture on discomfort in patients undergoing
   colonoscopy: protocol for a multicentre, randomised, controlled clinical
   trial
SO BMJ OPEN
LA English
DT Article
DE ANAESTHETICS; Clinical Trial; COMPLEMENTARY MEDICINE; Endoscopy
ID ACUPUNCTURE; ANESTHESIA; MECHANISMS; SEDATION; PROPOFOL; POSITION;
   CANCER; PAIN
AB Introduction Colonoscopy is currently the most commonly used and effective method for early detection, diagnosis and treatment of tumours of the colon and rectum. However, similar to other invasive procedures, it is associated with adverse reactions such as pain and abdominal distension. Electroacupuncture (EA) has been proposed as a potential treatment for relieving this discomfort; however, there is limited evidence supporting its efficacy. Therefore, the aim of this study is to investigate the effectiveness of EA when used prior to colonoscopy.Methods and analysis This multicentre, randomised, controlled, patient-assessor-blinded trial will be conducted at three hospitals in China. A total of 500 participants will be randomly assigned to either the EA group or sham EA (SEA) group, in a 1:1 ratio. EA will be administered for 30 min before the colonoscopy. Participants will be asked to complete detailed questionnaires within 10 min after the procedure and 24 hours after the procedure to record their symptoms. The primary outcome will be assessed using discomfort numeric rating scale (NRS) scores. Secondary outcomes will include participants' tolerance levels, including standard NRS scores for abdominal pain, bloating and anal discomfort reported by the participants, as well as heart rate(HR), blood pressure(BP), surgical pleth index, participant satisfaction, nurses' and endoscopists' evaluations, incidence of adverse events and salivary cortisol levels collected before EA and after colonoscopy.Ethics and dissemination Ethics approval was obtained from the Ethics Committee of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (number 2023-1327-94-01), Ethics Committee of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (number 2023LCSY059) and Ethics Committee of Wuxi Hospital Affiliated to Nanjing University of Traditional Chinese Medicine (number 2023-062-01). The results of this study will be disseminated in peer-reviewed publications. All potential participants will be provided informed consent before participating in the study.Trial registration number ChiCTR2300073485.
C1 [Sun, Xiangyu; Lu, Liyue; Wang, Chunchun; Lin, Chao; Xu, Kuangdi; Yong, Yue] Shanghai Univ Tradit Chinese Med, Shanghai Shuguang Hosp, Acupuncture Anesthesia Inst, Shanghai, Peoples R China.
   [Wang, Yongqiang; Chen, Wenting; Song, Jiangang] Shanghai Univ Tradit Chinese Med, Shanghai Shuguang Hosp, Dept Anesthesiol, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Chen, WT; Song, JA (corresponding author), Shanghai Univ Tradit Chinese Med, Shanghai Shuguang Hosp, Dept Anesthesiol, Shanghai, Peoples R China.
EM 1195121610@qq.com; lly.811@foxmail.com; saint517@shutcm.edu.cn;
   451621443@qq.com; lc_1203@126.com; 957714490@qq.com; yy_517@163.com;
   18789989@qq.com; songjg1993@shutcm.edu.cn
RI Sun, Xiangyu/LFT-7081-2024
FU Three-year Action Program of Shanghai Municipality for Traditional
   Chinese Medicine [ZY(2021-2023)-0211]
FX This work is financially supported by the Three-year Action Program of
   Shanghai Municipality for Traditional Chinese Medicine
   (ZY(2021-2023)-0211).
CR Amer-Cuenca JJ, 2011, EUR J PAIN, V15, P29, DOI 10.1016/j.ejpain.2010.05.006
   Barlas P, 2006, PAIN, V122, P81, DOI 10.1016/j.pain.2006.01.012
   Cappell MS, 2002, MED CLIN N AM, V86, P1217, DOI 10.1016/S0025-7125(02)00076-7
   Chen BL, 2022, J GASTROINTEST ONCOL, V13, P1169, DOI 10.21037/jgo-22-407
   Chen JM, 2021, ANN PALLIAT MED, V10, P2958, DOI 10.21037/apm-20-831
   Cohen LB, 2010, ALIMENT PHARM THER, V32, P425, DOI 10.1111/j.1365-2036.2010.04352.x
   Cooper GS, 2013, JAMA INTERN MED, V173, P551, DOI 10.1001/jamainternmed.2013.2908
   Dispersyn G, 2009, CLIN PHARMACOL THER, V85, P51, DOI 10.1038/clpt.2008.179
   Eberl S, 2020, ACUPUNCT MED, V38, P131, DOI 10.1136/acupmed-2017-011459
   Hamashima C, 2018, JPN J CLIN ONCOL, V48, P673, DOI 10.1093/jjco/hyy077
   Huang Y, 2023, BMJ OPEN, V13, DOI 10.1136/bmjopen-2023-075715
   Huiku M, 2007, BRIT J ANAESTH, V98, P447, DOI 10.1093/bja/aem004
   Krigel A, 2019, CLIN GASTROENTEROL H, V17, P2489, DOI 10.1016/j.cgh.2018.12.037
   Leung WW, 2011, J GASTROINTEST SURG, V15, P660, DOI 10.1007/s11605-011-1446-5
   Lu ZZ, 2015, J TRADIT CHIN MED, V35, P402, DOI 10.1016/S0254-6272(15)30116-3
   Nishizawa T, 2018, UNITED EUR GASTROENT, V6, P801, DOI 10.1177/2050640618767594
   Ouyang H, 2004, ALIMENT PHARM THER, V20, P831, DOI 10.1111/j.1365-2036.2004.02196.x
   Park B, 2023, CANCER RES TREAT, V55, P910, DOI 10.4143/crt.2022.1432
   Rastogi A, 2017, GASTROINTEST ENDOSC, V85, P59, DOI 10.1016/j.gie.2016.09.013
   Rudner R, 2003, GASTROINTEST ENDOSC, V57, P657, DOI 10.1067/mge.2003.207
   Schliessbach J, 2011, PAIN MED, V12, P268, DOI 10.1111/j.1526-4637.2010.01051.x
   Schneider A, 2006, GUT, V55, P649, DOI 10.1136/gut.2005.074518
   Ulett GA, 1998, BIOL PSYCHIAT, V44, P129, DOI 10.1016/S0006-3223(97)00394-6
   Vergis N, 2015, AM J GASTROENTEROL, V110, P1576, DOI 10.1038/ajg.2015.298
   Wang PQ, 2018, GUT, V67, P1626, DOI 10.1136/gutjnl-2017-315308
   Wernli KJ, 2016, GASTROENTEROLOGY, V150, P888, DOI 10.1053/j.gastro.2015.12.018
   Wu Justin Cy, 2010, J Neurogastroenterol Motil, V16, P306, DOI 10.5056/jnm.2010.16.3.306
   Xiao SD, 2001, GASTROINTEST ENDOSC, V53, P259, DOI 10.1067/mge.2001.112951
   Yang JW, 2022, ECLINICALMEDICINE, V49, DOI 10.1016/j.eclinm.2022.101472
   Yin X, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.20563
   Ylinen ER, 2009, J ADV NURS, V65, P2597, DOI 10.1111/j.1365-2648.2009.05119.x
   Yuan W, 2019, CHINESE MED J-PEKING, V132, P707, DOI 10.1097/CM9.0000000000000123
   Zhang H, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.861799
   Zhang RX, 2014, ANESTHESIOLOGY, V120, P482, DOI 10.1097/ALN.0000000000000101
   Zhao L, 2019, JAMA INTERN MED, V179, P1388, DOI 10.1001/jamainternmed.2019.2407
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zhou SJ, 2021, BRIT J ANAESTH, V127, pE56, DOI 10.1016/j.bja.2021.01.028
NR 37
TC 0
Z9 0
U1 0
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD DEC 17
PY 2024
VL 14
IS 12
AR e084628
DI 10.1136/bmjopen-2024-084628
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q1H6U
UT WOS:001382287000001
PM 39806660
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Noh, S
   Hong, Y
   Ha, J
   Kim, S
   Youn, I
   Nam, D
AF Noh, Seungjin
   Hong, Yejin
   Ha, Jisu
   Kim, Sunjoong
   Youn, Inae
   Nam, Dongwoo
TI Experiences of Patients With Breast Cancer Regarding Korean Medical
   Treatment Approaches: A Qualitative Study Protocol
SO INTERNATIONAL JOURNAL OF QUALITATIVE METHODS
LA English
DT Article
DE Korean medicine; breast cancer; qualitative research; grounded theory
   research
ID ALTERNATIVE MEDICINE; ACUPUNCTURE; COMPLEMENTARY; TRIAL; WOMEN
AB The importance of a complementary medical approach for patients with breast cancer is being emphasized to improve their quality of life and manage treatment-related symptoms. Korean medical treatment methods such as acupuncture, moxibustion, and herbal medicine are widely used to treat the side effects and sequelae of cancer treatment, such as pain, lymphedema, gastrointestinal disorders, and psychological issues. However, qualitative research on the perceptions of Korean patients with breast cancer regarding Korean medical treatment is lacking. This study aims to explore the how patients with breast cancer choose Korean medicine as a treatment option, patient experience regarding various therapeutic interventions, and their perception of the advantages and disadvantages of Korean medicine. A qualitative research methodology will be employed and semi-structured, in-depth interviews will be conducted with around 15 patients with breast cancer aged 19-75 years who have undergone Korean medical treatment, and each interview will last approximately 60-120 min. If necessary, interviews will be conducted up to three times. Data will be analyzed using the grounded theory methodology. This study will investigate the benefits and limitations of Korean medical treatment as a remedy for the medical needs of patients with breast cancer. These outcomes could be used as foundational data for future quantitative cancer research and serve as a basis for the development of patient-centered Korean medicine healthcare systems.
C1 [Noh, Seungjin; Youn, Inae] Kyung Hee Univ, Grad Sch, Dept Clin Korean Med, Seoul, South Korea.
   [Hong, Yejin; Nam, Dongwoo] Kyung Hee Univ, Korean Med Hosp, Dept Acupuncture & Moxibust, Seoul, South Korea.
   [Ha, Jisu; Kim, Sunjoong; Youn, Inae] Natl Med Ctr, Dept Acupuncture & Moxibust Med, 245 Eulji Ro, Seoul 04564, South Korea.
   [Nam, Dongwoo] Kyung Hee Univ, Coll Korean Med, Dept Acupuncture & Moxibust, 26 Kyungheedae Ro, Seoul 02447, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University
   Hospital; National Medical Center - Korea; Kyung Hee University
RP Youn, I (corresponding author), Natl Med Ctr, Dept Acupuncture & Moxibust Med, 245 Eulji Ro, Seoul 04564, South Korea.; Nam, D (corresponding author), Kyung Hee Univ, Coll Korean Med, Dept Acupuncture & Moxibust, 26 Kyungheedae Ro, Seoul 02447, South Korea.
EM eknowkey@naver.com; hanisanam@daum.net
RI ; Nam, Dongwoo/AAH-5090-2020
OI Kim, SunJoong/0000-0002-1950-7624; Hong, Yejin/0000-0002-8817-136X;
   Youn, Inae/0000-0002-1463-2178; Ha, Jisu/0000-0001-9486-8924; Nam,
   Dongwoo/0000-0002-7957-3121
FU National Medical Center, Republic of Korea; Korean Medicine Hospital
FX This research is supported by the Korean Medicine Hospital affiliated
   with Kyung Hee University and the National Medical Center, Republic of
   Korea. We express our gratitude to all of the potential participants of
   the study.
CR Arnold M, 2022, BREAST, V66, P15, DOI 10.1016/j.breast.2022.08.010
   Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Baum M, 2006, EUR J CANCER, V42, P1702, DOI 10.1016/j.ejca.2006.02.020
   Chien TJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419866910
   Choi JW, 2021, Journal of Korean Medicine Rehabilitation, V31, P75, DOI [10.18325/jkmr.2021.31.4.75, 10.18325/jkmr.2021.31.4.75, DOI 10.18325/JKMR.2021.31.4.75]
   Choy L.T., 2014, IOSR J HUMANITIES SO, V19, P99, DOI DOI 10.9790/0837-194399104
   Chun Tie Y, 2019, SAGE OPEN MED, V7, DOI 10.1177/2050312118822927
   Davies C, 2003, SOCIOL HEALTH ILL, V25, P172, DOI 10.1111/1467-9566.00346
   de Valois B, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/4298420
   Frierson GM, 2006, ANN BEHAV MED, V32, P77, DOI 10.1207/s15324796abm3201_9
   Greenlee H., 2017, CA: A Cancer Journal for Clinicians,
   Guetterman TC, 2015, Forum qualitative Sozialforschung, V16, P23, DOI 10.17169/fqs-16.2.2290
   Han G, 2022, CANCERS, V14, DOI 10.3390/cancers14194683
   Harbeck N, 2017, LANCET, V389, P1134, DOI [10.1016/S0140-6736(16)31891-8, 10.1016/s0140-6736(16)31891-8]
   Hong S, 2020, CANCER RES TREAT, V52, P335, DOI 10.4143/crt.2020.206
   Hwang JH, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/182475
   Ji Y., 2021, Evidence-basedComplementary
   Kim TH, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011793
   Lee DH, 2017, CASE REP ONCOL, V10, P27, DOI 10.1159/000455039
   Lengacher CA, 2006, ONCOL NURS FORUM, V33, P97, DOI 10.1188/06.ONF.97-104
   Li Q. W., 2020, Expert Systems with Applications
   Lincoln Y.S., 1986, NATURALISTIC EVALUAT, V30, P73, DOI [10.1002/ev.1427, DOI 10.1002/EV.1427, DOI 10.1002/EV]
   Liu F, 2022, BMC MED RES METHODOL, V22, DOI 10.1186/s12874-022-01768-6
   Lowe SS, 2015, INT J QUAL METH, V14, DOI 10.1177/1609406915617161
   Mouridsen HT, 2006, CURR MED RES OPIN, V22, P1609, DOI 10.1185/030079906X115667
   Muzzatti B, 2020, BMC CANCER, V20, DOI 10.1186/s12885-020-07272-8
   Nahleh Zeina, 2003, Palliat Support Care, V1, P267
   O'Brien BC, 2014, ACAD MED, V89, P1245, DOI 10.1097/ACM.0000000000000388
   Pan YQ, 2018, INTEGR CANCER THER, V17, P602, DOI 10.1177/1534735418786801
   Pinto AC, 2011, MATURITAS, V70, P343, DOI 10.1016/j.maturitas.2011.09.008
   Renjith V, 2021, INT J PREVENTIVE MED, V12, DOI 10.4103/ijpvm.IJPVM_321_19
   Saibul N, 2012, ASIAN PAC J CANCER P, V13, P4081, DOI 10.7314/APJCP.2012.13.8.4081
   Schapira MM, 2014, SUPPORT CARE CANCER, V22, P1207, DOI 10.1007/s00520-013-2073-3
   Senkus-Konefka E, 2007, CANCER TREAT REV, V33, P578, DOI 10.1016/j.ctrv.2007.07.011
   Shim JM, 2015, GLOBALIZATION HEALTH, V11, DOI 10.1186/s12992-015-0103-2
   Stöckigt B, 2021, INTEGR CANCER THER, V20, DOI 10.1177/15347354211058207
   Strauss A., 1997, GROUNDED THEORY PRAC, DOI DOI 10.1080/00049189608703156
   Tong A, 2007, INT J QUAL HEALTH C, V19, P349, DOI 10.1093/intqhc/mzm042
   Wang CH, 2018, Journal of Traditional Chinese Medical Sciences, V5, P255, DOI [10.1016/j.jtcms.2018.06.002, DOI 10.1016/J.JTCMS.2018.06.002]
   Yoon SW, 2014, INTEGR CANCER THER, V13, P310, DOI 10.1177/1534735413510023
   Zhang YZ, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.646315
NR 41
TC 1
Z9 2
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1609-4069
J9 INT J QUAL METH
JI Int. J. Qual. Meth.
PD APR
PY 2024
VL 23
AR 16094069241247476
DI 10.1177/16094069241247476
PG 7
WC Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics
GA NW6Y7
UT WOS:001203543600001
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Iravani, S
   Motlagh, AHK
   Razavi, SZE
   Shahi, F
   Wang, J
   Hou, L
   Sun, WJ
   Fard, MRA
   Aghili, M
   Karimi, M
   Rezaeizadeh, H
   Zhao, BX
AF Iravani, Somayeh
   Kazemi Motlagh, Amir Hooman
   Emami Razavi, Seyede Zahra
   Shahi, Farhad
   Wang, Jing
   Hou, Li
   Sun, Wenjun
   Afshari Fard, Mohammad Reza
   Aghili, Mahdi
   Karimi, Mehrdad
   Rezaeizadeh, Hossein
   Zhao, Baixiao
TI Effectiveness of Acupuncture Treatment on Chemotherapy-Induced
   Peripheral Neuropathy: A Pilot, Randomized, Assessor-Blinded, Controlled
   Trial
SO PAIN RESEARCH & MANAGEMENT
LA English
DT Article
ID QUALITY-OF-LIFE; CLINICAL IMPORTANCE; CANCER; PAIN; ELECTROACUPUNCTURE;
   MANAGEMENT; FATIGUE; PATIENT
AB Objective. This pilot study aims to evaluate the effectiveness and safety of acupuncture in the treatment of chemotherapy-induced peripheral neuropathy (CIPN). Methods. This study was a pilot randomized controlled trial, which was conducted with cooperation between Beijing University of Chinese Medicine (BUCM), China, and Tehran University of Medical Science (TUMS), Iran. Forty participants with CIPN were randomly assigned (1 : 1) to receive twelve sessions of acupuncture (20 minutes each session over 4 weeks) or take one 300 mg tablet of vitamin B1 and three 300 mg capsules of gabapentin per day for 4 weeks, after which both groups were followed up for 4 weeks. The primary endpoint was CIPN symptom severity measured by the Numerical Rating Scale (NRS). The secondary endpoints included sensory neuropathy grade evaluated by the National Cancer Institute-Common Toxicity Criteria for Adverse Events (NCI-CTCAE), neurophysiological assessment of CIPN by the nerve conduction study (NCS), and the patient overall satisfaction with treatment. Safety was assessed at each visit. Results. The NRS and NCI-CTCAE sensory neuropathy grading scales decreased significantly over time in both groups (both P < 0.001), with a significantly higher reduction in the acupuncture group (P < 0.001 and P = 0.03, respectively). In addition, the acupuncture group showed a higher overall satisfaction with the treatment at the end of treatment and after 4 weeks follow-up, in comparison with the vit B1 and gabapentin group (P = 0.01 and P = 0.001, respectively). The NCS (except for the latency of the sural nerve) in the acupuncture group improved significantly (P < 0.05), while improvement in the vit B1 and gabapentin group was not observed (P > 0.05). Conclusion. Our study revealed that acupuncture, as a kind of traditional Chinese therapeutic method, is significantly effective and safe in the treatment of CIPN. Moreover, acupuncture is more effective than using vitamin B1 and gabapentin as the conventional treatment.
C1 [Iravani, Somayeh; Afshari Fard, Mohammad Reza] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing 100029, Peoples R China.
   [Kazemi Motlagh, Amir Hooman; Karimi, Mehrdad; Rezaeizadeh, Hossein] Univ Tehran Med Sci, Sch Persian Med, Tehran, Iran.
   [Emami Razavi, Seyede Zahra] Univ Tehran Med Sci, Imam Khomeini Hosp Complex, Dept Phys Med & Rehabil, Tehran, Iran.
   [Shahi, Farhad] Univ Tehran Med Sci, Canc Inst Res Ctr, Imam Khomeini Hosp Complex, Dept Hematol & Med Oncol, Tehran, Iran.
   [Wang, Jing; Hou, Li] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Hematol & Oncol, Beijing 100700, Peoples R China.
   [Sun, Wenjun] Beijing Univ Chinese Med, Dept Neurol, Affiliated Hosp 3, Beijing 100029, Peoples R China.
   [Aghili, Mahdi] Univ Tehran Med Sci, Dept Radiat Oncol, Radiat Oncol Res Ctr, Tehran, Iran.
   [Zhao, Baixiao] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.
C3 Beijing University of Chinese Medicine; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Beijing University of Chinese Medicine; Beijing
   University of Chinese Medicine; Tehran University of Medical Sciences;
   Beijing University of Chinese Medicine
RP Zhao, BX (corresponding author), Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.
EM iravani_somayeh@bucm.edu.cn; hooman_k@tums.ac.ir;
   zemamirazavi@gmail.com; fshahi@yahoo.com; jwang2936@126.com;
   houli1203@126.com; doctorsunwenjun@126.com;
   afsharimohammadreza@bucm.edu.cn; aghili@tums.ac.ir;
   mehrdadkarimi@yahoo.com; rezaeizadeh@sina.tums.ac.ir;
   baixiao100@vip.sina.com
RI ; sun, wenjun/NQF-6978-2025; karimi, mehrdad/R-7149-2019; Wang,
   Jing/JEP-0007-2023
OI Hou, Li/0000-0003-2921-0821; Aghili, Mahdi/0000-0002-8150-618X; karimi,
   mehrdad/0000-0001-5395-819X; Emami Razavi, Seyede
   Zahra/0000-0001-8121-7217; Wang, Jing/0000-0002-2735-7283
FU National Natural Science Foundation of China [81874503]; Beijing
   University of Chinese Medicine; Tehran University of Medical Science
FX This study was supported by the National Natural Science Foundation of
   China (no. 81874503), Beijing University of Chinese Medicine, and Tehran
   University of Medical Science. The authors would like to express their
   appreciation to all the collaborators and participants of this study.
CR Abuaisha BB, 1998, DIABETES RES CLIN PR, V39, P115, DOI 10.1016/S0168-8227(97)00123-X
   Ahn Andrew C, 2007, Acupunct Med, V25, P11
   Bakogeorgos M, 2017, EXPERT REV ANTICANC, V17, P1045, DOI 10.1080/14737140.2017.1374856
   Bao T, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.0681
   Bao T, 2011, PAIN RES TREAT, V2011, DOI 10.1155/2011/920807
   Cavaletti G, 2013, ANN ONCOL, V24, P454, DOI 10.1093/annonc/mds329
   Chien TJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419886662
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   D'Alessandro EG, 2022, BMJ SUPPORT PALLIAT, V12, P64, DOI 10.1136/bmjspcare-2018-001542
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Deng B, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/2421876
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Dworkin RH, 2009, PAIN, V146, P238, DOI 10.1016/j.pain.2009.08.019
   Farrar JT, 2001, PAIN, V94, P149, DOI 10.1016/S0304-3959(01)00349-9
   Fradkin M, 2019, CURR MED CHEM, V26, P4698, DOI 10.2174/0929867326666190107163756
   Franconi G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/516916
   Giorgi F, 1996, AM J CLIN ONCOL-CANC, V19, P394, DOI 10.1097/00000421-199608000-00016
   Goh YL, 2014, J ACUPUNCT MERIDIAN, V7, P331, DOI 10.1016/j.jams.2014.02.004
   Haddad NE, 2014, INTEGR CANCER THER, V13, P371, DOI 10.1177/1534735413520181
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Hirayama Y, 2015, INT J CLIN ONCOL, V20, P866, DOI 10.1007/s10147-015-0810-y
   Jeong YJ, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/5367014
   Kim JH, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-254
   Kim SY, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/9874207
   Langevin HM, 2001, FASEB J, V15, P2275, DOI 10.1096/fj.01-0015hyp
   Litscher G, 2002, LASER MED SCI, V17, P19, DOI 10.1007/s10103-002-8262-9
   Liu ZS, 2013, CHIN J INTEGR MED, V19, P58, DOI 10.1007/s11655-013-1191-y
   Mandiroglu S, 2014, ACUPUNCT MED, V32, P194, DOI 10.1136/acupmed-2013-010491
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P228, DOI 10.1016/j.ctim.2006.09.009
   Molassiotis A, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419836501
   Park SB, 2013, CA-CANCER J CLIN, V63, P419, DOI 10.3322/caac.21204
   Phillips KD, 2004, J ALTERN COMPLEM MED, V10, P449, DOI 10.1089/1075553041323678
   Rostock M, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/349653
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   Starobova H, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00174
   Tong YQ, 2010, J ACUPUNCT MERIDIAN, V3, P95, DOI 10.1016/S2005-2901(10)60018-0
   Tsuchiya M, 2007, ANESTH ANALG, V104, P301, DOI 10.1213/01.ane.0000230622.16367.fb
   Vickers AJ, 2004, J CLIN ONCOL, V22, P1731, DOI 10.1200/JCO.2004.04.102
   Wong Raimond, 2006, Acupunct Med, V24, P87
   Xiong ZF, 2016, WORLD J ACUPUNCT-MOX, V26, P20, DOI 10.1016/S1003-5257(17)30005-3
   Yao C, 2016, CURR ONCOL, V23, pE27, DOI 10.3747/co.23.2788
   Zhang C, 2010, J TRADIT CHIN MED, V30, P13, DOI 10.1016/S0254-6272(10)60003-9
   Zhang SQ, 2017, J TRADIT CHIN MED, V37, P179
NR 47
TC 46
Z9 53
U1 8
U2 36
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1203-6765
EI 1918-1523
J9 PAIN RES MANAG
JI Pain Res. Manag.
PD JUN 29
PY 2020
VL 2020
AR 2504674
DI 10.1155/2020/2504674
PG 11
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA MQ2UU
UT WOS:000552753500002
PM 32676134
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Contim, CLV
   Santo, FHD
   Moretto, IG
AF Venancio Contim, Carolina Lelis
   do Espirito Santo, Fatima Helena
   Moretto, Isadora Gorski
TI Applicability of auriculotherapy in cancer patients: an integrative
   literature review
SO REVISTA DA ESCOLA DE ENFERMAGEM DA USP
LA English
DT Review
DE Complementary Therapies; Auriculotherapy; Acupuncture; Ear; Neoplasms;
   Oncology Nursing; Review
ID AURICULAR POINT ACUPRESSURE; RANDOMIZED CONTROLLED-TRIAL; CHEMOTHERAPY;
   CONSTIPATION; SLEEP
AB Objective: To analyze scientific evidence in the literature on the use of auriculotherapy to relieve symptoms related to cancer and/or its treatment. Method: An integrative literature review based on: MEDLINE, CINAHL, LILACS, SCOPUS and COCHRANE in the last five years in English, Portuguese and Spanish. Inclusion criteria: primary studies with the central theme. Exclusion criteria: opinion articles, reviews and experience reports. Results: The search resulted in 435 publications, but only 11 remained after applying four selection stages. An analysis of the study designs showed that three of them (27.5%) had a high level of evidence, three (27.5%) had moderate, four (36%) had low and one (9%) had a very low level. The evaluated outcomes were related to the following symptoms: pain, constipation, nausea and vomiting, hot flashes, dyspnea, fatigue and insomnia. Moreover, 100% of the publications exposed positive effects of auriculotherapy in oncology. Conclusion: Auriculotherapy in cancer patients improves symptoms, and this practice was considered a safe and acceptable intervention. However, it is necessary to expand studies to obtain more favorable evidence since only 3 studies presented a high level of evidence.
C1 [Venancio Contim, Carolina Lelis; Moretto, Isadora Gorski] Inst Nacl Canc INCA, Rio De Janeiro, RJ, Brazil.
   [do Espirito Santo, Fatima Helena] Univ Fed Fluminense, Escola Enfermagem Aurora de Afonso Costa, Dept Enfermagem Med Cirurg, Niteroi, RJ, Brazil.
C3 National Cancer Institute (Inca); Universidade Federal Fluminense
RP Contim, CLV (corresponding author), Rua Mariz & Barros 840,Cobertura 02, BR-20270002 Rio De Janeiro, RJ, Brazil.
EM carolina.lelis@yahoo.com.br
RI ; Espírito Santo, Fátima Helena/CAH-3848-2022
OI Contim, Carolina/0000-0002-4213-3181; Moretto,
   Isadora/0000-0002-6546-8929; Espírito Santo, Fátima
   Helena/0000-0003-4611-5586
CR Bonassa E M. A., 2012, Terapeutica oncologica para enfermeiros e farmaceuticos, V4a
   Costa TC, 2015, REV ESC ENFERM USP, V49, P332, DOI 10.1590/S0080-623420150000200020
   Curtinaz ML, 2017, Revista Espaço Ciência & Saúde, V5, P4
   de Souza MT, 2010, EINSTEIN-SAO PAULO, V8, P102, DOI [10.1590/S1679-45082010RW1134, 10.1590/s1679-45082010rw1134]
   do Prado JM, 2018, REV ESC ENFERM USP, V52, DOI [10.1590/S1980-220X2017030403334, 10.1590/s1980-220x2017030403334]
   Eghbali M, 2016, COMPLEMENT THER CLIN, V24, P189, DOI 10.1016/j.ctcp.2016.06.006
   Galvao TF, 2015, EPIDEMIOL SERV SAUDE, V24, P173
   Hanai A, 2016, BREAST CANCER RES TR, V155, P99, DOI 10.1007/s10549-015-3652-4
   Hughes JG, 2015, EUR J INTEGR MED, V7, P623, DOI 10.1016/j.eujim.2015.08.003
   Instituto Nacional de Cancer Jose Alencar Gomes da Silva, 2018, EST 2018 INC CANC BR
   Instituto Nacional de Cancer Jose Alencar Gomes da Silva, 2017, ABC CANC AB BAS CONT
   Kuo HC, 2018, RES NURS HEALTH, V41, P469, DOI 10.1002/nur.21885
   Li Y, 2017, J CANCER RES THER, V13, P844, DOI 10.4103/jcrt.JCRT_709_17
   Luz Madel T., 2005, Physis, V15, P145
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Mendes Karina Dal Sasso, 2008, Texto contexto - enferm., V17, P758
   Ministerio da Saude (BR), 2015, POL NAC PRAT INT COM
   Polit DF, 2019, Fundamentos de pesquisa em enfermagem: avaliacao de evidencias para a pratica da enfermagem
   Shin J, 2018, WESTERN J NURS RES, V40, P67, DOI 10.1177/0193945916680362
   Strong RA, 2016, J PALLIAT MED, V19, P556, DOI 10.1089/jpm.2015.0347
   Tan JY, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/506758
   Telesi Júnior Emílio, 2016, Estud. av., V30, P99, DOI [10.1590/s0103-40142016.00100007, 10.1590/S0103-40142016.00100007]
   Ursi Elizabeth Silva, 2006, Rev. Latino-Am. Enfermagem, V14, P124
   Viel E, 2016, CLIMACTERIC, V19, P274, DOI 10.3109/13697137.2016.1164135
   Yeh CH, 2017, ONCOL NURS FORUM, V44, P476, DOI 10.1188/17.ONF.476-487
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Yeh CH, 2015, PAIN MANAG NURS, V16, P285, DOI 10.1016/j.pmn.2014.08.005
   Yeon Shin， Na, 2018, [Korean Journal of Adult Nursing, 성인간호학회지], V30, P227, DOI [10.7475/kjan.2018.30.3.227, 10.7475/kjan.2018.30.3.227]
NR 28
TC 8
Z9 12
U1 2
U2 29
PU UNIV SAO PAOLO
PI CERQUERA CESAR
PA AV  DR ENEAS DE CARVALHO AGUIAR, 419, CERQUERA CESAR, SP 05403-000,
   BRAZIL
SN 0080-6234
EI 1980-220X
J9 REV ESC ENFERM USP
JI Rev. Esc. Enferm. USP
PY 2020
VL 54
AR e03609
DI 10.1590/S1980-220X2019001503609
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA NK4FA
UT WOS:000566686800001
PM 32901659
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tofthagen, C
   Boses, S
   Healy, G
   Jooma, N
AF Tofthagen, Cindy
   Boses, Sarah
   Healy, Gene
   Jooma, Nuruddin
TI Evaluation of Group Acupuncture for Cancer-Related Symptoms: A
   Retrospective Analysis
SO JOURNAL OF PALLIATIVE MEDICINE
LA English
DT Article
ID INDUCED PERIPHERAL NEUROPATHY; CHEMOTHERAPY
AB Background: Acupuncture is being used for treatment of cancer-related symptoms in numerous settings, yet empirical evidence supporting the effects of acupuncture in this setting is lacking. Group acupuncture is an economical way to provide acupuncture to patients at a reduced cost. Objective: In this retrospective study we sought to evaluate the effects of group acupuncture on specific cancer-related symptoms in persons receiving outpatient cancer treatment. Methods: Patients were receiving group acupuncture treatments through an integrative oncology program in a large community oncology practice in west central Florida. A short patient-completed assessment of seven basic cancer-related symptoms using a 0-10 numeric rating scale was completed at each acupuncture treatment. Basic demographic information, including age, gender, race/ethnicity, and cancer type was obtained from the medical record. Paired sample t-tests were used to evaluate differences in symptoms before the first treatment and at the fourth treatment. Results: Fifty patients completed at least four weekly acupuncture treatments in 2014. Forty-three of them completed symptom assessments and were included in this analysis. The mean age of participants was 66.4 years. The majority of patients were white, non-Hispanic, and female. No significant improvement in symptoms were identified at the third treatment. At the time of the fourth group acupuncture, participants reported significantly less pain/numbness and problems with digestion. Discussion: The results of this study provide evidence to support the efficacy of group acupuncture for pain, neuropathy, and digestive problems in persons with cancer. A minimum of four weekly treatments may be necessary before improvements are noted. Limitations include a retrospective design, incomplete symptom evaluation, and possible response bias. Future studies of group acupuncture for cancer-related symptoms should utilize a prospective, controlled design, use validated measures to thoroughly evaluate targeted symptoms, and include a more racially and ethnically diverse sample.
C1 [Tofthagen, Cindy] Univ S Florida, Coll Nursing, Tampa, FL 33612 USA.
   [Boses, Sarah; Jooma, Nuruddin] Florida Canc Specialists, Integrat Oncol Dept, Largo, FL USA.
   [Healy, Gene] Root Healing Acupuncture, Dunedin, FL USA.
C3 State University System of Florida; University of South Florida; Florida
   Cancer Specialists
RP Tofthagen, C (corresponding author), Univ S Florida, Coll Nursing, 12901 Bruce B Downs Blvd,MDC22, Tampa, FL 33612 USA.
EM ctofthag@health.usf.edu
CR Bao T, 2011, PAIN RES TREATMENT, V2011
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Franconi G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/516916
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Haddad NE, 2014, INTEGR CANCER THER, V13, P371, DOI 10.1177/1534735413520181
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Tas D, 2014, ASIAN PAC J CANCER P, V15, P3139, DOI 10.7314/APJCP.2014.15.7.3139
   Wong Raimond, 2006, Acupunct Med, V24, P87
NR 9
TC 12
Z9 13
U1 0
U2 15
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-6218
EI 1557-7740
J9 J PALLIAT MED
JI J. Palliat. Med.
PD OCT 1
PY 2015
VL 18
IS 10
BP 878
EP 880
DI 10.1089/jpm.2015.0143
PG 3
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA CS7MY
UT WOS:000362268900015
PM 26218367
DA 2026-01-16
ER

PT J
AU Mehling, WE
   Lown, EA
   Dvorak, CC
   Cowan, MJ
   Horn, BN
   Dunn, EA
   Acree, M
   Abrams, DI
   Hecht, FM
AF Mehling, Wolf E.
   Lown, E. Anne
   Dvorak, Christopher C.
   Cowan, Morton J.
   Horn, Biljana N.
   Dunn, Elizabeth A.
   Acree, Michael
   Abrams, Donald I.
   Hecht, Frederick M.
TI Hematopoietic Cell Transplant and Use of Massage for Improved Symptom
   Management: Results from a Pilot Randomized Control Trial
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID POSTTRAUMATIC STRESS SYMPTOMS; CHILDHOOD-CANCER; NURSING INTERVENTION;
   INTEGRATIVE MEDICINE; PEDIATRIC CANCER; SUPPORT PROGRAM; BREAST-CANCER;
   CHILDREN; THERAPY; NAUSEA
AB Background. Pediatric hematopoietic cell transplant (HCT) is a lifesaving treatment that often results in physical and psychological discomfort. An acupressure-massage intervention may improve symptom management in this setting. Methods. This randomized controlled pilot trial compared a combined massage-acupressure intervention to usual care. Children were offered three practitioner-provided sessions per week throughout hospitalization. Parents were trained to provide additional acupressure as needed. Symptoms were assessed using nurses' reports and two questionnaires, the behavioral affective and somatic experiences scale and the Peds quality of life cancer module. Results. We enrolled 23 children, ages 5 to 18. Children receiving the intervention reported fewer days of mucositis (Hedges' g effect size ES = 0.63), lower overall symptom burden (ES = 0.26), feeling less tired and run-down (ES = 0.86), having fewer moderate/severe symptoms of pain, nausea, and fatigue (ES = 0.62), and less pain (ES = 0.42). The intervention group showed trends toward increasing contentness/serenity (ES = +0.50) and decreasing depression (ES = -0.45), but not decreased anxiety (ES = +0.42). Differences were not statistically significant. Discussion. Feasibility of studying massage-acupressure was established in children undergoing HCT. Larger studies are needed to test the efficacy of such interventions in reducing HCT-associated symptoms in children.
C1 [Mehling, Wolf E.; Acree, Michael; Abrams, Donald I.; Hecht, Frederick M.] Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94115 USA.
   [Mehling, Wolf E.] Univ Calif San Francisco, Dept Family & Community Med, San Francisco, CA 94115 USA.
   [Lown, E. Anne] Inst Publ Hlth, Alcohol Res Grp, Emeryville, CA 94608 USA.
   [Dvorak, Christopher C.; Cowan, Morton J.; Horn, Biljana N.; Dunn, Elizabeth A.] Univ Calif San Francisco, Dept Pediat, Blood & Marrow Transplant Div, San Francisco, CA 94143 USA.
   [Abrams, Donald I.] Univ Calif San Francisco, Dept Med Hematol & Oncol, San Francisco, CA 94110 USA.
   [Hecht, Frederick M.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94115 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   Alcohol Research Group; Public Health Institute; University of
   California System; University of California San Francisco; University of
   California System; University of California San Francisco; University of
   California System; University of California San Francisco
RP Mehling, WE (corresponding author), Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94115 USA.
EM mehlingw@ocim.ucsf.edu
RI Dvorak, Christopher/AAX-1630-2020
OI Dvorak, Christopher/0000-0002-6146-3952; Hecht,
   Frederick/0000-0002-5782-1171
FU Community Foundation Sonoma County, Santa Rosa California
FX The authors thank the children and parents who took part in this study;
   the Community Foundation Sonoma County, Santa Rosa California that
   sponsored the study; massage/acupressure practitioners Marcia Degelman,
   Paula Koepke, and Jnani Chapman; research assistants Kristina Kavanau,
   Viranjini Gopisetty, and Derek Ramsey; the nurses on the children's
   hospital's transplant unit with Trish Murphy and Sara Okane as nurse
   coordinators. Wolf E. Mehling and E. Anne Lown contributed equally to
   this paper.
CR Ackerman S., 2010, MASSAGE CHILDREN UND
   Ahles TA, 1999, J PAIN SYMPTOM MANAG, V18, P157, DOI 10.1016/S0885-3924(99)00061-5
   American Massage Therapy Association, 2003, MEMB SERV 2003
   [Anonymous], 1994, DSM 4
   Barlow J H, 2007, Psychol Health Med, V12, P64, DOI 10.1080/13548500600580931
   Barlow JH, 2008, J PSYCHOSOM RES, V64, P55, DOI 10.1016/j.jpsychores.2007.06.006
   Beider S, 2007, EVID-BASED COMPL ALT, V4, P23, DOI 10.1093/ecam/nel068
   Billhult A, 2001, CANCER NURS, V24, P180, DOI 10.1097/00002820-200106000-00003
   Billhult A, 2007, J ALTERN COMPLEM MED, V13, P53, DOI 10.1089/acm.2006.6049
   Billhult Annika, 2009, Complement Ther Clin Pract, V15, P96, DOI 10.1016/j.ctcp.2008.10.003
   BLOTCKY AD, 1985, J PEDIATR PSYCHOL, V10, P479, DOI 10.1093/jpepsy/10.4.479
   Bower JE, 2009, CLIN CANCER RES, V15, P5534, DOI 10.1158/1078-0432.CCR-08-2584
   BROWN RT, 1993, J AM ACAD CHILD PSY, V32, P554, DOI 10.1097/00004583-199305000-00010
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   CASSILETH PA, 1993, J CLIN ONCOL, V11, P314, DOI 10.1200/JCO.1993.11.2.314
   Chao LF, 2009, BREAST CANCER RES TR, V118, P255, DOI 10.1007/s10549-009-0533-8
   Corbin Lisa, 2005, Cancer Control, V12, P158
   Corner Jessica, 1995, Int J Palliat Nurs, V1, P67, DOI 10.12968/ijpn.1995.1.2.67
   Dibble S L, 2000, Oncol Nurs Forum, V27, P41
   Dolgin M. J., 1996, CANC FAMILY
   Dune LS, 2006, EXPLORE-NY, V2, P314, DOI 10.1016/j.explore.2006.04.004
   Ezzo JM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002285.pub2
   Ezzo J, 2006, J ALTERN COMPLEM MED, V12, P489, DOI 10.1089/acm.2006.12.489
   Fellowes D., 2004, COCHRANE DB SYST REV, DOI [DOI 10.1002/14651858, 10.1002/14651858.CD002287.pub2, DOI 10.1002/14651858.CD002287.PUB2]
   FERRELLTORRY AT, 1993, CANCER NURS, V16, P93
   Field T, 2002, MED CLIN N AM, V86, P163, DOI 10.1016/S0025-7125(03)00078-6
   FIELD T, 1995, J DEV BEHAV PEDIATR, V16, P105
   FIFE B, 1987, SOC SCI MED, V24, P159, DOI 10.1016/0277-9536(87)90248-6
   FOA EB, 1993, J TRAUMA STRESS, V6, P459, DOI 10.1007/BF00974317
   Fredrickson BL, 2003, J PERS SOC PSYCHOL, V84, P365, DOI 10.1037/0022-3514.84.2.365
   Fuemmeler BF, 2005, CHILD HEALTH CARE, V34, P289, DOI 10.1207/s15326888chc3404_4
   Gardani G, 2007, Minerva Med, V98, P665
   Grealish L, 2000, CANCER NURS, V23, P237, DOI 10.1097/00002820-200006000-00012
   Green B. L., 2004, TRAUMA HLTH PHYS HLT, P247
   Hernandez-Reif M, 2004, J PSYCHOSOM RES, V57, P45, DOI 10.1016/S0022-3999(03)00500-2
   Jane SW, 2008, CANCER NURS, V31, pE24, DOI 10.1097/01.NCC.0000339242.51291.85
   Jane SW, 2009, J PAIN SYMPTOM MANAG, V37, P754, DOI 10.1016/j.jpainsymman.2008.04.021
   Jones Emily, 2008, J Soc Integr Oncol, V6, P141
   Kazak AE, 2004, J PEDIATR PSYCHOL, V29, P211, DOI 10.1093/jpepsy/jsh022
   Kazak AE, 2005, J PEDIATR PSYCHOL, V30, P29, DOI 10.1093/jpepsy/jsi013
   Kim Y, 2008, J AGING HEALTH, V20, P483, DOI 10.1177/0898264308317533
   Kutner JS, 2008, ANN INTERN MED, V149, P369, DOI 10.7326/0003-4819-149-6-200809160-00003
   Logan RM, 2007, CANCER TREAT REV, V33, P448, DOI 10.1016/j.ctrv.2007.03.001
   Lown E. A., 2011, P AM PSYCH SOC C AN
   Maciocia G., 1989, The foundations of Chinese medicine: A comprehensive text for acupuncturists and herbalists
   MAGNI G, 1986, ACTA PAEDIATR SCAND, V75, P283, DOI 10.1111/j.1651-2227.1986.tb10200.x
   Mehling WE, 2007, J PAIN SYMPTOM MANAG, V33, P258, DOI 10.1016/j.jpainsymman.2006.09.016
   Mertens AC, 2008, PEDIATR BLOOD CANCER, V50, P90, DOI 10.1002/pbc.21177
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P228, DOI 10.1016/j.ctim.2006.09.009
   Moyer CA, 2004, PSYCHOL BULL, V130, P3, DOI 10.1037/0033-2909.130.1.3
   Myers Cynthia D, 2008, J Soc Integr Oncol, V6, P19
   Phipps S, 1999, INT J CANCER, P18
   Phipps S, 1994, J Pediatr Oncol Nurs, V11, P109, DOI 10.1177/104345429401100305
   Phipps Sean, 2002, Pediatr Rehabil, V5, P223
   Phipps S, 2010, CANCER-AM CANCER SOC, V116, P3924, DOI 10.1002/cncr.25415
   Pöder U, 2008, PSYCHO-ONCOLOGY, V17, P430, DOI 10.1002/pon.1263
   Post-White J, 2009, J PEDIATR ONCOL NURS, V26, P16, DOI 10.1177/1043454208323295
   Post-White Janice, 2003, Integr Cancer Ther, V2, P332, DOI 10.1177/1534735403259064
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Rexilius Stephanie J, 2002, Oncol Nurs Forum, V29, pE35, DOI 10.1188/02.ONF.E35-E44
   Sanders Jean E., 1997, P357
   Shafer AB, 2006, J CLIN PSYCHOL, V62, P123, DOI 10.1002/jclp.20213
   Shanghai College of Traditional Medicine, 1981, ACUP COMPR TEXT
   Sherman Karen J, 2006, BMC Complement Altern Med, V6, P24, DOI 10.1186/1472-6882-6-24
   Shin YH, 2004, CANCER NURS, V27, P267, DOI 10.1097/00002820-200407000-00002
   Sloper P, 2000, J PEDIATR PSYCHOL, V25, P79, DOI 10.1093/jpepsy/25.2.79
   Streitberger K, 2006, AUTON NEUROSCI-BASIC, V129, P107, DOI 10.1016/j.autneu.2006.07.015
   Stuber ML, 1997, PEDIATRICS, V100, P958, DOI 10.1542/peds.100.6.958
   Sundberg T, 2007, BMC HEALTH SERV RES, V7, DOI 10.1186/1472-6963-7-107
   Sundberg T, 2009, BMC COMPLEM ALTERN M, V9, DOI 10.1186/1472-6882-9-33
   van der Riet P, 1999, Aust J Holist Nurs, V6, P4
   Varni JW, 2004, J DEV BEHAV PEDIATR, V25, P239, DOI 10.1097/00004703-200408000-00003
   Varni JW, 2002, CANCER-AM CANCER SOC, V94, P2090, DOI 10.1002/cncr.10428
   Williams HL, 2005, COMPLEMENT THER MED, V13, P107, DOI 10.1016/j.ctim.2005.03.007
   Yim YK, 2007, EVID-BASED COMPL ALT, V4, P51, DOI 10.1093/ecam/nel054
NR 75
TC 24
Z9 33
U1 0
U2 28
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2012
VL 2012
AR 450150
DI 10.1155/2012/450150
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA 906RI
UT WOS:000301364400001
PM 22454665
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Liu, YH
   Ye, Y
   Zheng, JB
   Wang, XQ
   Zhang, Y
   Lin, HS
AF Liu, Yi-Hua
   Ye, Yang
   Zheng, Jia-Bin
   Wang, Xue-Qian
   Zhang, Ying
   Lin, Hong-Sheng
TI Acupuncture for enhancing early recovery of bowel function in cancer
   Protocol for a systematic review
SO MEDICINE
LA English
DT Review
DE acupuncture; bowel function; cancer; POI; protocol; systematic review
ID PROLONGED POSTOPERATIVE ILEUS; QUALITY-OF-LIFE; ELECTROACUPUNCTURE;
   MECHANISMS; PROMOTES; SURGERY; CARE
AB Background: Cancer patients undergoing surgical procedure often suffer from bowel dysfunction and postoperative ileus (POI). Cancer management for early recovery of bowel function is still a challenging topic. Acupuncture has been commonly used in a variety of gastrointestinal diseases. The aim of this study is to evaluate the effects of acupuncture therapy to reduce the duration of POI and enhance bowel function in cancer patients.
   Methods: We will systematically screen all randomized controlled trials (RCTs) published through electronically and hand searching. The following search engines including Medline, EMBASE, Cochrane CENTRAL, the Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, the Chinese Biomedical Literature Database, the China National Knowledge Infrastructure, VIP Information, Wanfang Data, one Japanese database (Japan Science and Technology Information Aggregator, Electronic) and 2 Korean Medical Databases (Korean Studies Information, and Data Base Periodical Information Academic) will be retrieved. Supplementary sources will be searched including gray literature, conference proceedings, and potential identified publications. Two reviewers will independently conduct the trial inclusion, data extraction and assess the quality of studies. The time to first passing flatus and time to first bowel motion will be assessed as the primary outcomes. Adverse effects, time to first bowel sound, visual analog scale (VAS) pain score, hospital stay, and postoperative analgesic requirement will be measured as secondary outcomes. Methodological quality will be evaluated according to the Cochrane risk of bias. Details of interventions will be assessed by the Standards for Reporting Interventions in Controlled Trials of Acupuncture (STRICTA) checklist. All analyses will be applied by RevMan (version 5.3) and StataSE (version 12).
   Ethics and Dissemination: This systematic review will provide up-to-date information on acupuncture therapy for early recovery of bowel function in cancer patients. This review does not require ethical approval and will be reported in a peer-reviewed journal and presented at a relevant conference.
C1 [Liu, Yi-Hua; Ye, Yang; Zheng, Jia-Bin; Wang, Xue-Qian] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
   [Liu, Yi-Hua; Ye, Yang; Zheng, Jia-Bin; Wang, Xue-Qian; Zhang, Ying; Lin, Hong-Sheng] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Oncol, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Guang'anmen Hospital, CACMS;
   China Academy of Chinese Medical Sciences
RP Lin, HS (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Beijing 100053, Peoples R China.
EM drlinhongsheng_@126.com
RI Ye, Yang/GXM-4085-2022; Lin, HS/GQP-5238-2022
OI Ye, Yang/0000-0003-2314-4579; 
FU State Administration of Traditional Chinese Medicine of the People's
   Republic of China [201307006]; International S&T Cooperation Program
   Office of China [2013DFA32540]
FX This work was supported by the State Administration of Traditional
   Chinese Medicine of the People's Republic of China (number 201307006)
   and the International S&T Cooperation Program Office of China (number
   2013DFA32540).
CR [Anonymous], AC PDQR HLTH PROF VE
   Artinyan A, 2008, WORLD J SURG, V32, P1495, DOI 10.1007/s00268-008-9491-2
   Asgeirsson T, 2010, J AM COLL SURGEONS, V210, P228, DOI 10.1016/j.jamcollsurg.2009.09.028
   Bauer AJ, 2004, NEUROGASTROENT MOTIL, V16, P54, DOI 10.1111/j.1743-3150.2004.00558.x
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Fang JF, 2017, SCI REP-UK, V7, DOI 10.1038/srep39801
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Guyatt GH, 2008, BRIT MED J, V336, P924, DOI 10.1136/bmj.39489.470347.AD
   2011, BMJ-BRIT MED J, V343, pd5928, DOI [DOI 10.1136/BMJ.D5928, 10.1136/bmj.d5928]
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Kehlet H, 2008, NAT CLIN PRACT GASTR, V5, P552, DOI 10.1038/ncpgasthep1230
   Kehlet H, 2008, LANCET, V371, P791, DOI 10.1016/S0140-6736(08)60357-8
   Kronberg U, 2011, ANN SURG, V253, P78, DOI 10.1097/SLA.0b013e3181fcb83e
   Langenhoff BS, 2001, BJS-BRIT J SURG, V88, P643, DOI 10.1046/j.1365-2168.2001.01755.x
   Li H, 2015, WORLD J GASTROENTERO, V21, P8304, DOI 10.3748/wjg.v21.i27.8304
   Lian WL, 2014, CHIN J INTEGR MED, V20, P136, DOI 10.1007/s11655-013-1439-1
   Liberati Alessandro, 2009, PLoS Med, V6, pe1000100, DOI 10.1371/journal.pmed.1000100
   Luo D, 2008, DIGEST DIS SCI, V53, P689, DOI 10.1007/s10620-007-9929-7
   Lv JQ, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-153
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Meng ZQ, 2010, WORLD J GASTROENTERO, V16, P104, DOI 10.3748/wjg.v16.i1.104
   Miller ND, 2014, ACUPUNCT MED, V32, P139, DOI 10.1136/acupmed-2013-010465
   Neuman HB, 2007, ANN SURG ONCOL, V14, P1727, DOI 10.1245/s10434-006-9283-6
   Ng SSM, 2013, GASTROENTEROLOGY, V144, P307, DOI 10.1053/j.gastro.2012.10.050
   Person B, 2006, CURR PROB SURG, V43, P6, DOI 10.1067/j.cpsurg.2005.10.003
   Stang A, 2010, EUR J EPIDEMIOL, V25, P603, DOI 10.1007/s10654-010-9491-z
   Tada H, 2003, DIGEST DIS SCI, V48, P59, DOI 10.1023/A:1021730314068
   van Bree SHW, 2014, ANN SURG, V259, P708, DOI 10.1097/SLA.0b013e318293ee55
   van Bree SHW, 2012, NAT REV GASTRO HEPAT, V9, P675, DOI 10.1038/nrgastro.2012.134
   Vather R, 2014, CLIN EXP PHARMACOL P, V41, P358, DOI 10.1111/1440-1681.12220
   Vather R, 2013, J GASTROINTEST SURG, V17, P962, DOI 10.1007/s11605-013-2148-y
   Wang CP, 2008, J ALTERN COMPLEM MED, V14, P833, DOI 10.1089/acm.2008.0107
   Yin JY, 2010, AM J PHYSIOL-GASTR L, V298, pG563, DOI 10.1152/ajpgi.00252.2009
NR 33
TC 2
Z9 2
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR
PY 2017
VL 96
IS 17
AR e6644
DI 10.1097/MD.0000000000006644
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ET6ZL
UT WOS:000400442700012
PM 28445263
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lu, WD
   Rosenthal, DS
AF Lu, Weidong
   Rosenthal, David S.
TI Recent Advances in Oncology Acupuncture and Safety Considerations in
   Practice
SO CURRENT TREATMENT OPTIONS IN ONCOLOGY
LA English
DT Editorial Material
ID CONTROLLED-TRIAL; CANCER-PATIENTS; BREAST-CANCER; SYMPTOMS; THERAPY;
   XEROSTOMIA; MANAGEMENT
AB Oncology acupuncture is a new and emerging field of research. Recent advances from published clinical trials have added evidence to support the use of acupuncture for symptom management in cancer patients. Recent new developments include (1) pain and dysfunction after neck dissection; (2) radiation-induced xerostomia in head and neck cancer; (3) aromatase inhibitor-associated arthralgia in breast cancer; (4) hot flashes in breast cancer and prostate cancer; and (5) chemotherapyinduced neutropenia in ovarian cancer. Some interventions are becoming a non-pharmaceutical option for cancer patients, while others still require further validation and confirmation. Meanwhile, owing to the rapid development of the field and increased demands from cancer patients, safety issues concerning oncology acupuncture practice have become imperative. Patients with cancer may be at higher risk developing adverse reactions from acupuncture. Practical strategies for enhancing safety measures are discussed and recommended.
C1 [Lu, Weidong; Rosenthal, David S.] Dana Farber Canc Inst, Leonard P Zakim Ctr Integrat Therapies, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Dana-Farber
   Cancer Institute
RP Lu, WD (corresponding author), Dana Farber Canc Inst, Leonard P Zakim Ctr Integrat Therapies, SW560,44 Binney St, Boston, MA 02115 USA.
EM Weidong_lu@dfci.harvard.edu
RI Lu, Weidong/C-3844-2008
OI Lu, Weidong/0000-0003-2838-6307
FU NCCIH NIH HHS [5K01AT004415, K01 AT004415] Funding Source: Medline
CR Ashamalla H, 2011, INT J RADIAT ONCOL, V79, P1358, DOI 10.1016/j.ijrobp.2010.01.025
   Beer TM, 2010, UROLOGY, V76, P1182, DOI 10.1016/j.urology.2010.03.033
   BLOM M, 1992, ORAL SURG ORAL MED O, V73, P293, DOI 10.1016/0030-4220(92)90124-9
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Deng Gary E, 2009, J Soc Integr Oncol, V7, P85
   Garcia MK, 2009, HEAD NECK-J SCI SPEC, V31, P1360, DOI 10.1002/hed.21110
   Ge AXY, 2010, J ALTERN COMPLEM MED, V16, P811, DOI 10.1089/acm.2009.0456
   Ladas EJ, 2010, SUPPORT CARE CANCER, V18, P1487, DOI 10.1007/s00520-010-0926-6
   Lu WD, 2010, INTEGR CANCER THER, V9, P284, DOI 10.1177/1534735410378856
   Lu WD, 2009, J ALTERN COMPLEM MED, V15, P745, DOI 10.1089/acm.2008.0589
   MacPherson H, 2001, Acupunct Med, V19, P93
   Pfister DG, 2010, J CLIN ONCOL, V28, P2565, DOI 10.1200/JCO.2009.26.9860
   Sagar SM, 2008, CURR TREAT OPTION ON, V9, P117, DOI 10.1007/s11864-008-0063-3
   Sun Bao-Mu, 2010, Zhong Xi Yi Jie He Xue Bao, V8, P641
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   White Adrian, 2004, Acupunct Med, V22, P122
NR 17
TC 44
Z9 51
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1527-2729
EI 1534-6277
J9 CURR TREAT OPTION ON
JI Curr. Treat. Options Oncol.
PD DEC
PY 2010
VL 11
IS 3-4
BP 141
EP 146
DI 10.1007/s11864-010-0126-0
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 691SJ
UT WOS:000285100800011
PM 21103962
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Dev, R
   Bruera, E
AF Dev, Rony
   Bruera, Eduardo
TI Treatment options for persistent pain and numbness in cancer survivors
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Editorial Material; Early Access
DE Pain; numbness; cancer survivors; exercise; alternative medicine
ID INDUCED PERIPHERAL NEUROPATHY; BREAST-CANCER; MUSCULOSKELETAL SYMPTOMS;
   AROMATASE INHIBITORS; AMERICAN SOCIETY; CONTROLLED-TRIAL; ACUPUNCTURE;
   PREVENTION; ARTHRALGIA; MANAGEMENT
C1 [Dev, Rony; Bruera, Eduardo] Univ Texas MD Anderson Canc Ctr, Symptom Control & Palliat Med, Houston, TX USA.
   [Dev, Rony] Univ Texas MD Anderson Canc Ctr, Symptom Control & Palliat Med, 1515 Holcombe Blvd Unit 1212, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; UTMD Anderson Cancer Center
RP Dev, R (corresponding author), Univ Texas MD Anderson Canc Ctr, Symptom Control & Palliat Med, 1515 Holcombe Blvd Unit 1212, Houston, TX 77030 USA.
EM rdev@mdanderson.org
CR Abe H, 2022, ANN PALLIAT MED, DOI 10.21037/apm-22-420
   Aziz NM, 2003, SEMIN RADIAT ONCOL, V13, P248, DOI 10.1016/S1053-4296(03)00024-9
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Brier MJ, 2018, EUR J CANCER, V91, P145, DOI 10.1016/j.ejca.2017.12.006
   Briot K, 2010, BREAST CANCER RES TR, V120, P127, DOI 10.1007/s10549-009-0692-7
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Chou R, 2015, ANN INTERN MED, V162, P276, DOI 10.7326/M14-2559
   Fenton JJ, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.16726
   Galantino ML, 2012, INTEGR CANCER THER, V11, P313, DOI 10.1177/1534735411413270
   Glare P, 2022, DRUGS, V82, P275, DOI 10.1007/s40265-022-01675-6
   Hershman DL, 2015, J CLIN ONCOL, V33, P1910, DOI 10.1200/JCO.2014.59.5595
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Irwin ML, 2015, J CLIN ONCOL, V33, P1104, DOI 10.1200/JCO.2014.57.1547
   Jairam V, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.13605
   Kuehn BM, 2022, JAMA-J AM MED ASSOC, V327, P2387, DOI 10.1001/jama.2022.10100
   Loprinzi CL, 2020, J CLIN ONCOL, V38, DOI 10.1200/JCO.20.01399
   Maihöfner C, 2021, SUPPORT CARE CANCER, V29, P4223, DOI 10.1007/s00520-021-06042-x
   Mols F, 2014, SUPPORT CARE CANCER, V22, P2261, DOI 10.1007/s00520-014-2255-7
   Ng AH, 2021, JCO ONCOL PRACT, V17, P440, DOI 10.1200/OP.20.00625
   Paice JA, 2016, J CLIN ONCOL, V34, P3325, DOI 10.1200/JCO.2016.68.5206
   Pergolizzi JV, 2021, FRONT PAIN RES, V2, DOI 10.3389/fpain.2021.691720
   Prinsloo S, 2017, CANCER-AM CANCER SOC, V123, P1989, DOI 10.1002/cncr.30649
   Tait RC, 2018, J PAIN, V19, P1367, DOI 10.1016/j.jpain.2018.06.002
   van den Beuken-van Everdingen MHJ, 2016, J PAIN SYMPTOM MANAG, V51, P1070, DOI 10.1016/j.jpainsymman.2015.12.340
   Yuksel SS, 2022, JPRAS OPEN, V31, P32, DOI 10.1016/j.jpra.2021.10.009
NR 25
TC 0
Z9 0
U1 1
U2 3
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD 2022 DEC 19
PY 2022
DI 10.21037/apm-22-1392
EA DEC 2022
PG 4
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 7M5SZ
UT WOS:000906718200001
PM 36627856
OA gold
DA 2026-01-16
ER

PT J
AU Hershman, DL
   Unger, JM
   Greenlee, H
   Capodice, JL
   Lew, DL
   Darke, AK
   Kengla, AT
   Melnik, MK
   Jorgensen, C
   Kreisle, WH
   Minasian, LM
   Fisch, MJ
   Henry, NL
   Crew, KD
AF Hershman, Dawn L.
   Unger, Joseph M.
   Greenlee, Heather
   Capodice, Jillian L.
   Lew, Danika L.
   Darke, Amy K.
   Kengla, Alice T.
   Melnik, Marianne K.
   Jorgensen, CarlaW.
   Kreisle, William H.
   Minasian, Lori M.
   Fisch, Michael J.
   Henry, N. Lynn
   Crew, Katherine D.
TI Effect of Acupuncture vs Sham Acupuncture or Waitlist Control on Joint
   Pain Related to Aromatase Inhibitors Among Women With Early-Stage Breast
   Cancer A Randomized Clinical Trial
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article; Proceedings Paper
CT San Antonio Breast Cancer Symposium
CY DEC 05-09, 2017
CL San Antonio, TX
ID QUALITY-OF-LIFE; MUSCULOSKELETAL SYMPTOMS; IMMPACT RECOMMENDATIONS;
   HORMONAL-THERAPY; ARTHRALGIA; OUTCOMES; PLACEBO; DISCONTINUATION;
   MULTICENTER; VALIDATION
AB IMPORTANCE Musculoskeletal symptoms are the most common adverse effects of aromatase inhibitors and often result in therapy discontinuation. Small studies suggest that acupuncture may decrease aromatase inhibitor-related joint symptoms.
   OBJECTIVE To determine the effect of acupuncture in reducing aromatase inhibitor-related joint pain.
   DESIGN, SETTING, AND PATIENTS Randomized clinical trial conducted at 11 academic centers and clinical sites in the United States from March 2012 to February 2017 (final date of follow-up, September 5, 2017). Eligible patients were postmenopausal women with early-stage breast cancer who were taking an aromatase inhibitor and scored at least 3 on the Brief Pain Inventory Worst Pain (BPI-WP) item (score range, 0-10; higher scores indicate greater pain).
   INTERVENTIONS Patients were randomized 2: 1: 1 to the true acupuncture (n = 110), sham acupuncture (n = 59), or waitlist control (n = 57) group. True acupuncture and sham acupuncture protocols consisted of 12 acupuncture sessions over 6 weeks (2 sessions per week), followed by 1 session per week for 6 weeks. The waitlist control group did not receive any intervention. All participants were offered 10 acupuncture sessions to be used between weeks 24 and 52.
   MAIN OUTCOMES AND MEASURES The primary end point was the 6-week BPI-WP score. Mean 6-week BPI-WP scores were compared by study group using linear regression, adjusted for baseline pain and stratification factors (clinically meaningful difference specified as 2 points).
   RESULTS Among 226 randomized patients (mean [SD] age, 60.7 [8.6] years; 88% white; mean [SD] baseline BPI-WP score, 6.6 [1.5]), 206 (91.1%) completed the trial. From baseline to 6 weeks, the mean observed BPI-WP score decreased by 2.05 points (reduced pain) in the true acupuncture group, by 1.07 points in the sham acupuncture group, and by 0.99 points in the waitlist control group. The adjusted difference for true acupuncture vs sham acupuncture was 0.92 points (95% CI, 0.20-1.65; P = .01) and for true acupuncture vs waitlist control was 0.96 points (95% CI, 0.24-1.67; P = .01). Patients in the true acupuncture group experienced more grade 1 bruising compared with patients in the sham acupuncture group (47% vs 25%; P = .01).
   CONCLUSIONS AND RELEVANCE Among postmenopausal women with early-stage breast cancer and aromatase inhibitor-related arthralgias, true acupuncture compared with sham acupuncture or with waitlist control resulted in a statistically significant reduction in joint pain at 6 weeks, although the observed improvement was of uncertain clinical importance.
C1 [Hershman, Dawn L.] Columbia Univ, Med Ctr, New York, NY USA.
   [Unger, Joseph M.; Greenlee, Heather; Lew, Danika L.; Darke, Amy K.] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
   [Unger, Joseph M.; Lew, Danika L.; Darke, Amy K.] SWOG Stat & Data Management Ctr, Seattle, WA USA.
   [Capodice, Jillian L.] Mt Sinai Hosp, New York, NY 10029 USA.
   [Kengla, Alice T.] Kaiser Permanente Med Ctr, Walnut Creek, CA USA.
   [Melnik, Marianne K.] Spectrum Hlth Med Grp, Grand Rapids, MI USA.
   [Jorgensen, CarlaW.] NCORP Carolinas Greenville Hlth Syst, Greenville, SC USA.
   [Kreisle, William H.] St Lukes Mt States Tumor Inst PCRC NCORP, Boise, ID USA.
   [Minasian, Lori M.] NCI, Canc Prevent Div, Bethesda, MD 20892 USA.
   [Fisch, Michael J.] AIM Specialty Hlth, Chicago, IL USA.
   [Henry, N. Lynn] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA.
C3 Columbia University; Fred Hutchinson Cancer Center; Southwest Oncology
   Group; Icahn School of Medicine at Mount Sinai; Kaiser Permanente;
   Spectrum Health Medical Group; National Institutes of Health (NIH) -
   USA; NIH National Cancer Institute (NCI); Utah System of Higher
   Education; University of Utah; Huntsman Cancer Institute
RP Hershman, DL (corresponding author), Columbia Univ, 161 Ft Washington Ave,10-1068, New York, NY 10032 USA.
EM dlh23@columbia.edu
RI Unger, Joseph/O-7457-2019; Hershman, Dawn/AAG-2114-2020; Greenlee,
   Heather/A-1439-2011
OI Darke, Amy/0000-0002-9821-2065; Henry, N Lynn/0000-0002-4771-5930; 
FU National Institutes of Health (NIH) National Center for Complementary
   and Integrative Health; Office of Research on Women's Health
   [R01AT006376]; NIH/NCI/DCP (Division of Cancer Prevention) [UG1CA189974,
   U10CA37429]; National Cancer Institute [UG1CA189974] Funding Source: NIH
   RePORTER
FX Funding was provided by the National Institutes of Health (NIH) National
   Center for Complementary and Integrative Health and the Office of
   Research on Women's Health R01AT006376; NIH/NCI/DCP (Division of Cancer
   Prevention) grant UG1CA189974 and legacy grant U10CA37429.
CR [Anonymous], J EVID BASED MED
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   BELLAMY N, 1988, J RHEUMATOL, V15, P1833
   Burstein HJ, 2016, J CLIN ONCOL, V34, P1689, DOI 10.1200/JCO.2015.65.9573
   Castel LD, 2013, CANCER-AM CANCER SOC, V119, P2375, DOI 10.1002/cncr.28016
   Chirgwin JH, 2016, J CLIN ONCOL, V34, P2452, DOI 10.1200/JCO.2015.63.8619
   Crew KD, 2007, J CLIN ONCOL, V25, P3877, DOI 10.1200/JCO.2007.10.7573
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   DAUT RL, 1983, PAIN, V17, P197, DOI 10.1016/0304-3959(83)90143-4
   Dworkin RH, 2008, J PAIN, V9, P105, DOI 10.1016/j.jpain.2007.09.005
   Dworkin RH, 2009, PAIN, V146, P238, DOI 10.1016/j.pain.2009.08.019
   Fallowfield LJ, 1999, BREAST CANCER RES TR, V55, P189
   Farrar JT, 2001, PAIN, V94, P149, DOI 10.1016/S0304-3959(01)00349-9
   Garcia SF, 2007, J CLIN ONCOL, V25, P5106, DOI 10.1200/JCO.2007.12.2341
   Goss PE, 2016, NEW ENGL J MED, V375, P209, DOI 10.1056/NEJMoa1604700
   Greenlee H, 2015, ACUPUNCT MERIDIAN ST, V8, P452
   Helms J.M., 1995, Acupuncture energetics: A clinical approach for physicians
   Henry NL, 2018, J CLIN ONCOL, V36, P326, DOI 10.1200/JCO.2017.74.6651
   Henry NL, 2015, J CLIN ONCOL, V33, P1870, DOI 10.1200/JCO.2015.61.1004
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Hershman DL, 2015, J CLIN ONCOL, V33, P1910, DOI 10.1200/JCO.2014.59.5595
   Hershman DL, 2010, J CLIN ONCOL, V28, P4120, DOI 10.1200/JCO.2009.25.9655
   Hui Kathleen K S, 2007, BMC Complement Altern Med, V7, P33, DOI 10.1186/1472-6882-7-33
   Irwin ML, 2015, J CLIN ONCOL, V33, P1104, DOI 10.1200/JCO.2014.57.1547
   Kroenke K, 2010, JAMA-J AM MED ASSOC, V304, P163, DOI 10.1001/jama.2010.944
   LAIRD NM, 1982, BIOMETRICS, V38, P963, DOI 10.2307/2529876
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   National Institutes of Health, 2015, RAC ETHN CAT DEF NIH
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   OKEN MM, 1982, AM J CLIN ONCOL-CANC, V5, P649, DOI 10.1097/00000421-198212000-00014
   POCOCK SJ, 1975, BIOMETRICS, V31, P103, DOI 10.2307/2529712
   SAS Institute Inc, 2016, SAS 9 4 SYST OPT, V5th
   Sautner J, 2004, RHEUMATOLOGY, V43, P1409, DOI 10.1093/rheumatology/keh360
   Shapiro AC, 2016, BREAST CANCER RES TR, V155, P501, DOI 10.1007/s10549-016-3710-6
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Tedesco D, 2017, JAMA SURG, V152, DOI 10.1001/jamasurg.2017.2872
   Zou GY, 2004, AM J EPIDEMIOL, V159, P702, DOI 10.1093/aje/kwh090
NR 38
TC 242
Z9 290
U1 7
U2 158
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUL 10
PY 2018
VL 320
IS 2
BP 167
EP 176
DI 10.1001/jama.2018.8907
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine
GA GM4MM
UT WOS:000438094900017
PM 29998338
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Li, Y
   Wu, YQ
   Xiang, YQ
   Zhang, SN
AF Li, Ying
   Wu, Y. Q.
   Xiang, Y. Q.
   Zhang, S. N.
TI Effect of Acupuncture Combined with Tuina on Cervical Curvature and
   Serum Inflammatory Cytokine Levels in Patients with Cervical Spondylosis
SO INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Cervical spondylosis; acupuncture; tuina; cervical curvature;
   interleukin-4; interleukin-8; tumor necrosis factor-alpha
ID FUSION; DISKECTOMY; MYELOPATHY; CAGE
AB To study the effects of acupuncture and tuina by stages on cervical curvature, serum interleukin-4, interleukin-8 and tumor necrosis factor-alpha in patients with cervical spondylosis. A total of 94 patients with cervical spondylosis admitted from June 2020 to June 2021 were divided into the control group and the study group through random number table with 47 cases in each group. Patients in the control group were treated with tuina and patients in the study group were treated with acupuncture and tuina by stages. One course of treatment was 21 d and both groups were treated for 2 courses. The clinical effects of the patients in the two groups after treatment were compared, the cervical spine curvature and visual analogue scale scores of patients in the two groups before and after treatment were compared and the serum levels of interleukin-4, interleukin-8 and tumor necrosis factor-alpha before and after treatment were compared. The total clinical effective rate of patients in the study group was 91.48 % (43/47), which was higher than 68.09 % (32/47) of patients in the control group. After treatment, the C value of cervical spine physiological curvature of patients in the two groups was higher than that before treatment and the visual analog scale scores, serum interleukin-4, interleukin-8, tumor necrosis factor-alpha levels decreased. The improvement of patients in the study group was better than that in the control group (all p<0.05). Acupuncture and tuina to treat patients with cervical spondylosis by stages can better improve the curvature of the patient's cervical spines, reduce pain, inhibit inflammation in the body and improve the therapeutic effect.
C1 [Zhang, S. N.] Nanjing Univ Chinese Med, Affiliated Hosp, Nanjing 210029, Jiangsu, Peoples R China.
   [Li, Ying; Wu, Y. Q.; Xiang, Y. Q.] Gannan Med Univ, Sch Rehabil Med, Ganzhou 341000, Jiangxi, Peoples R China.
C3 Nanjing University of Chinese Medicine; Gannan Medical University
RP Zhang, SN (corresponding author), Nanjing Univ Chinese Med, Affiliated Hosp, Nanjing 210029, Jiangsu, Peoples R China.
EM zhangshinian@sina.com
OI Li, Ying/0009-0006-9579-5193
FU scientific research project of traditional Chinese medicine of Jiangxi
   Provincial Health and Family Planning Commission [2018A103]
FX This work was supported by the scientific research project of
   traditional Chinese medicine of Jiangxi Provincial Health and Family
   Planning Commission (No. 2018A103).
CR Angevine PD, 2003, SPINE, V28, P931, DOI 10.1097/00007632-200305010-00016
   Barbagallo GMV, 2013, EUR SPINE J, V22, pS868, DOI 10.1007/s00586-013-3005-0
   Bartels RHMA, 2005, NEUROSURGERY, V57, pE194, DOI 10.1227/01.NEU.0000163419.59635.78
   Brkaric M, 2007, J SPINAL DISORD TECH, V20, P248, DOI 10.1097/BSD.0b013e318030d2f3
   Chen Y, 2016, CLIN NEUROL NEUROSUR, V144, P72, DOI 10.1016/j.clineuro.2016.03.010
   Cheung ZB, 2019, GLOB SPINE J, V9, P446, DOI 10.1177/2192568218774576
   Korinth MC, 2008, ZBL NEUROCHIR, V69, P113, DOI 10.1055/s-2008-1081201
   Luo JQ, 2015, EUR SPINE J, V24, P1621, DOI 10.1007/s00586-015-3911-4
   Matz PG, 2007, NEUROSURGERY, V60, P64, DOI 10.1227/01.NEU.0000215399.67006.05
   Nouri A, 2017, SPINE, V42, P1058, DOI 10.1097/BRS.0000000000001981
   Nouri A, 2015, SPINE, V40, pE675, DOI 10.1097/BRS.0000000000000913
   Song KJ, 2009, SPINE, V34, P2886, DOI 10.1097/BRS.0b013e3181b64f2c
   Tasiou Anastasia, 2017, J Spine Surg, V3, P444, DOI [10.21037/jss.2017.08.03, 10.21037/jss.2017.08.03]
NR 13
TC 1
Z9 1
U1 3
U2 24
PU INDIAN PHARMACEUTICAL ASSOC
PI MUMBAI
PA KALINA, SANTA CRUZ EAST, MUMBAI, 00000, INDIA
SN 0250-474X
EI 1998-3743
J9 INDIAN J PHARM SCI
JI Indian J. Pharm. Sci.
PY 2021
VL 83
SI 6
BP 205
EP 209
DI 10.36468/pharmaceutical-sciences.spl.395
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ZP1JF
UT WOS:000766180500032
OA gold
DA 2026-01-16
ER

PT J
AU Mukherji, A
   Glickman-Simon, R
AF Mukherji, Atreyi
   Glickman-Simon, Richard
TI MINDFULNESS-BASED STRESS REDUCTION FOR POSTTRAUMATIC STRESS DISORDER,
   COFFEE CONSUMPTION AND MORTALITY, PHYTOESTROGENS FOR MENOPAUSE, LIGHT
   THERAPY FOR NON-SEASONAL DEPRESSION, ELECTROACUPUNCTURE FOR LABOR PAIN
SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
LA English
DT Editorial Material
ID CARDIOVASCULAR-DISEASE; CAFFEINE INTAKE; MOOD DISORDERS; RISK; SYMPTOMS;
   EFFICACY; METAANALYSIS; CANCER; MEDITATION; CARCINOMA
C1 [Mukherji, Atreyi] McMaster Univ, Internal Med & Infect Dis, Hamilton, ON L8S 4L8, Canada.
   [Mukherji, Atreyi] McMaster Univ, Integrat Med, Hamilton, ON L8S 4L8, Canada.
   [Mukherji, Atreyi] McMaster Univ, Hamilton, ON L8S 4L8, Canada.
   [Glickman-Simon, Richard] Tufts Univ, Sch Med, Publ Hlth & Family Med, Boston, MA 02111 USA.
   [Glickman-Simon, Richard] DynaMed, Ipswich, MA USA.
C3 McMaster University; McMaster University; McMaster University; Tufts
   University
RP Mukherji, A (corresponding author), McMaster Univ, Internal Med & Infect Dis, Hamilton, ON L8S 4L8, Canada.; Mukherji, A (corresponding author), McMaster Univ, Integrat Med, Hamilton, ON L8S 4L8, Canada.; Mukherji, A (corresponding author), McMaster Univ, Hamilton, ON L8S 4L8, Canada.
CR Adams J, 2009, BIRTH-ISS PERINAT C, V36, P237, DOI 10.1111/j.1523-536X.2009.00328.x
   Avis NE, 2001, SOC SCI MED, V52, P345, DOI 10.1016/S0277-9536(00)00147-7
   Bedell S, 2014, J STEROID BIOCHEM, V139, P225, DOI 10.1016/j.jsbmb.2012.12.004
   Chen MN, 2015, CLIMACTERIC, V18, P260, DOI 10.3109/13697137.2014.966241
   Crippa A, 2014, AM J EPIDEMIOL, V180, P763, DOI 10.1093/aje/kwu194
   Ding M, 2015, CIRCULATION, V132, P2305, DOI 10.1161/CIRCULATIONAHA.115.017341
   Ding M, 2014, CIRCULATION, V129, P643, DOI 10.1161/CIRCULATIONAHA.113.005925
   Ding M, 2014, DIABETES CARE, V37, P569, DOI 10.2337/dc13-1203
   Dong C, 2015, ARCH GYNECOL OBSTET, V291, P531, DOI 10.1007/s00404-014-3427-x
   Eden JA, 2012, MATURITAS, V72, P157, DOI 10.1016/j.maturitas.2012.03.006
   Even C, 2008, J AFFECT DISORDERS, V108, P11, DOI 10.1016/j.jad.2007.09.008
   Ferrari AJ, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001547
   Forbes D, 2012, J ANXIETY DISORD, V26, P442, DOI 10.1016/j.janxdis.2012.01.006
   Frost ND, 2014, J TRAUMA STRESS, V27, P1, DOI 10.1002/jts.21881
   Fulton JJ, 2015, J ANXIETY DISORD, V31, P98, DOI 10.1016/j.janxdis.2015.02.003
   Golden RN, 2005, AM J PSYCHIAT, V162, P656, DOI 10.1176/appi.ajp.162.4.656
   Goyal M, 2014, JAMA INTERN MED, V174, P357, DOI 10.1001/jamainternmed.2013.13018
   Jacobs A, 2009, MOL NUTR FOOD RES, V53, P1084, DOI 10.1002/mnfr.200800552
   Je Y, 2014, BRIT J NUTR, V111, P1162, DOI 10.1017/S0007114513003814
   Je Y, 2012, INT J CANCER, V131, P1700, DOI 10.1002/ijc.27408
   Kessler RC, 2000, J CLIN PSYCHIAT, V61, P4
   Kurozawa Y, 2005, BRIT J CANCER, V93, P607, DOI 10.1038/sj.bjc.6602737
   Lam RW, 2016, JAMA PSYCHIAT, V73, P56, DOI 10.1001/jamapsychiatry.2015.2235
   Lang AJ, 2012, BEHAV MODIF, V36, P759, DOI 10.1177/0145445512441200
   Lethaby A, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001395.pub4
   Leung L, 2012, J ACUPUNCT MERIDIAN, V5, P261, DOI 10.1016/j.jams.2012.07.017
   Mårtensson B, 2015, J AFFECT DISORDERS, V182, P1, DOI 10.1016/j.jad.2015.04.013
   McClung CA, 2011, EUR NEUROPSYCHOPHARM, V21, pS683, DOI 10.1016/j.euroneuro.2011.07.008
   Monson CM, 2008, PSYCHOL ASSESSMENT, V20, P131, DOI 10.1037/1040-3590.20.2.131
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   O'Keefe JH, 2013, J AM COLL CARDIOL, V62, P1043, DOI 10.1016/j.jacc.2013.06.035
   Polusny MA, 2015, JAMA-J AM MED ASSOC, V314, P456, DOI 10.1001/jama.2015.8361
   Resick PA, 2015, J CONSULT CLIN PSYCH, V83, P1058, DOI 10.1037/ccp0000016
   Riesco E, 2011, CLIMACTERIC, V14, P573, DOI 10.3109/13697137.2011.566652
   Ross GW, 2000, JAMA-J AM MED ASSOC, V283, P2674, DOI 10.1001/jama.283.20.2674
   Rossouw JE, 2002, JAMA-J AM MED ASSOC, V288, P321, DOI 10.1001/jama.288.3.321
   Schnurr PP, 2007, JAMA-J AM MED ASSOC, V297, P820, DOI 10.1001/jama.297.8.820
   Smith CA, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009232
   Song FJ, 2012, CANCER RES, V72, P3282, DOI 10.1158/0008-5472.CAN-11-3511
   THOMPSON LU, 1991, NUTR CANCER, V16, P43, DOI 10.1080/01635589109514139
   Tuunainen A, 2004, Cochrane Database Syst Rev, pCD004050, DOI 10.1002/14651858.CD004050.pub2
   Vixner L, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-187
   Waraich P, 2004, CAN J PSYCHIAT, V49, P124, DOI 10.1177/070674370404900208
   Westrin Asa, 2007, Ann Clin Psychiatry, V19, P239
   Wilson KM, 2011, JNCI-J NATL CANCER I, V103, P876, DOI 10.1093/jnci/djr151
NR 45
TC 0
Z9 0
U1 0
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-8307
EI 1878-7541
J9 EXPLORE-NY
JI Explore-J Sci. Heal.
PD MAY-JUN
PY 2016
VL 12
IS 3
BP 210
EP 214
DI 10.1016/j.explore.2016.02.013
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA DL7MN
UT WOS:000375824900012
PM 27061036
DA 2026-01-16
ER

PT J
AU Jeon, E
   Kwak, M
   Shin, I
   Kang, S
   Shon, H
   Jung, E
AF Jeon, Eonju
   Kwak, Minah
   Shin, Imhee
   Kang, Seokbong
   Shon, Hosang
   Jung, Euidal
TI Acupuncture for the Treatment of Fatigue after Total Thyroidectomy in
   Women with Papillary Thyroid Cancer: A Pilot Study
SO ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH
LA English
DT Article
DE Acupuncture; Fatigue; Quality of life; Papillary thyroid cancer; Total
   thyroidectomy; Weight gain
ID QUALITY-OF-LIFE; PERSISTENT POSTTREATMENT FATIGUE; MANAGEMENT; BREAST
AB Objectives: Papillary thyroid cancer (PTC) is the most common type of thyroid cancer and the most common endocrine malignancy. Although it has a good prognosis, patients experience weight gain, fatigue, and neck pain after total thyroidectomy, and quality of life (QOL) can also decline. There is no effective treatment for these symptoms. This study evaluated the feasibility and safety of acupuncture for treating of fatigue in patients with PTC after total thyroidectomy. Methods: This is a prospective randomized controlled study using before and after measurements. The subjects included 25 patients with thyroid cancer who had undergone total thyroidectomy and were experiencing fatigue. Twelve patients underwent Saam (or Sa-Ahm) acupuncture treatment and thirteen subjects did not. Saam acupuncture, which is one of the original therapeutic modalities representing traditional Korean medicine, is a unique treatment method that has a different origin than the modalities from China and Japan. The basic characteristic of combining five shu points in Saam acupuncture is the selection of the tonification and sedation points along the self-meridian and other meridians based on creation and governor relationships. Acupuncture treatment was delivered two times a week for 6 weeks, in 25 to 30 minutes at each session. Acupoints were individually tailored according to the individual pattern of each patient. Fatigue severity and QOL were evaluated using the fatigue scale score and Short Form-36 (SF-36), respectively. Fatigue severity scale is a 9-item self-report questionnaire scale developed by Krupp et al. in 1989. SF-36 is a 36-item, patient-reported survey of patient health. Body weight, body mass index, fatigue scale score, and SF-36 score were evaluated pre- and post-treatment, and laboratory tests for biochemical variables were also performed. Results: Fatigue scale score (FSS) significantly improved in the acupuncture group (FSS; 29.92 to 19.50, decrease; 91.7%) compared to the control group (FSS; 29.92 to 31.15, decrease; 46.2%) at post-treatment compared to baseline (p=0.011). SF-36 scores were 74.12 in the acupuncture group and 69.02 in the control group, with no statistically significant difference (p=0.085). Weight change did not differ between the two groups. Liver enzymes such as aspartate aminotransferase were lower in the acupuncture group (27.67 to 24.33 IU/L) than in the control group (20.77 to 24.08 IU/L) (p=0.01). No other biochemical markers differed between the two groups. Conclusions: Acupuncture such as ST-36, CV-4, KI-10, and HT-8 may relieve fatigue and improve QOL in patients PTC who experience fatigue, and reduced QOL after total thyroidectomy without biochemical changes. A larger prospective study is required to confirm these effects.
C1 [Jeon, Eonju; Shon, Hosang; Jung, Euidal] Catholic Univ Daegu, Sch Med, Dept Internal Med, 33 Duryugongwon Ro,17 Gil, Daegu, South Korea.
   [Kwak, Minah; Kang, Seokbong] Daegu Haany Univ, Coll Korean Med, Dept Internal Med, Daegu, South Korea.
   [Shin, Imhee] Catholic Univ Daegu, Sch Med, Dept Med Stat, Daegu, South Korea.
C3 Catholic University of Daegu; Daegu Haany University; Catholic
   University of Daegu
RP Jung, E (corresponding author), Catholic Univ Daegu, Sch Med, Dept Internal Med, 33 Duryugongwon Ro,17 Gil, Daegu, South Korea.
EM jed15@cu.ac.kr
FU Ministry of Health & Welfare, Republic of Korea
   [090-091-3000-3033-340-320-01]
FX This research was supported by a grant from the Ministry of Health &
   Welfare, Republic of Korea (Project No: 090-091-3000-3033-340-320-01)
CR Ahn CB, 2009, J ACUPUNCT MERIDIAN, V2, P309, DOI 10.1016/S2005-2901(09)60074-1
   [Anonymous], 2010, SHANGHAI J ACU MOX
   Aytac B, 2005, SAUDI MED J, V26, P1746
   Cooper DS, 2009, THYROID, V19, P1167, DOI 10.1089/thy.2009.0110
   Debry C, 1995, Ann Otolaryngol Chir Cervicofac, V112, P211
   Dong Jia-Zi, 2018, Zhen Ci Yan Jiu, V43, P335, DOI 10.13702/j.1000-0607.171010
   Gamper EM, 2015, EUR J NUCL MED MOL I, V42, P1179, DOI 10.1007/s00259-015-3022-9
   Gonçalves J, 2005, OTOLARYNG HEAD NECK, V132, P490, DOI 10.1016/j.otohns.2004.09.028
   Haugen BR, 2016, THYROID, V26, P1, DOI 10.1089/thy.2015.0020
   Hegyi G, 2013, ACUPUNCTURE ELECTRO, V38, P161, DOI 10.3727/036012913X13831832269243
   Huang SM, 2004, J ADV NURS, V47, P492, DOI 10.1111/j.1365-2648.2004.03128.x
   Hyodo I, 2005, J CLIN ONCOL, V23, P2645, DOI 10.1200/JCO.2005.04.126
   Jeong YJ, 2015, MED ACUPUNCT, V27, P206, DOI 10.1089/acu.2014.1071
   Kim KW, 2010, SAAM ACUPUNCTURE MET
   Kwon HJ, 2015, Open Journal of Immunology, V05, P90, DOI [10.4236/oji.2015.53010, 10.4236/oji.2015.53010]
   Lee MH, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/130324
   Mendoza A, 2004, THYROID, V14, P133, DOI 10.1089/105072504322880373
   Omura Y, 2013, ACUPUNCTURE ELECTRO, V38, P37, DOI 10.3727/036012913X13831831849484
   Osmolski Antoni, 2006, Otolaryngol Pol, V60, P165
   Park M, 2015, EVID-BASED COMPL ALT, V2015
   Pellegriti G, 2013, J CANCER EPIDEMIOL, V2013, DOI 10.1155/2013/965212
   Rogers P A, 1992, Probl Vet Med, V4, P162
   Sawka AM, 2014, ENDOCRIN METAB CLIN, V43, P475, DOI 10.1016/j.ecl.2014.02.007
   Stone P, 2001, J PAIN SYMPTOM MANAG, V22, P1007, DOI 10.1016/S0885-3924(01)00361-X
   Sun GX, 2015, J CLIN ACUPUNCT MOXI, V31, P23
   To J, 2015, THYROID, V25, P198, DOI 10.1089/thy.2014.0418
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
   Yim YK, 2006, WORLD J GASTROENTERO, V12, P2245, DOI 10.3748/wjg.v12.i14.2245
   Yin CS, 2007, NEUROL RES, V29, pS10, DOI 10.1179/016164107X172301
   ANN ONCOLOGY, V11, P561
   2011, THYROID, V21, P1339, DOI DOI 10.1089/THY.2010.0393
   2016, ACTA ONCOL, V55, P365, DOI DOI 10.3109/0284186X.2015.1102965
   2013, THYROID, V23, P1247, DOI DOI 10.1089/THY.2013.0015
   2013, ACTA ONCOL, V52, P249, DOI DOI 10.3109/0284186X.2012.741326
NR 34
TC 3
Z9 3
U1 3
U2 36
PU COGNIZANT COMMUNICATION CORP
PI PUTNAM VALLEY
PA 18 PEEKSKILL HOLLOW RD, PO BOX 37, PUTNAM VALLEY, NY 10579 USA
SN 0360-1293
EI 2167-9010
J9 ACUPUNCTURE ELECTRO
JI Acupunct. Electro-Ther. Res.
PY 2019
VL 44
IS 1
BP 23
EP 38
DI 10.3727/036012919X15549226100464
PG 16
WC Integrative & Complementary Medicine; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Neurosciences & Neurology
GA HY1VV
UT WOS:000467906200003
DA 2026-01-16
ER

PT J
AU Andreazzoli, F
   Yurkovski, IL
   Ben-Arye, E
   Bonucci, M
AF Andreazzoli, Francesca
   Yurkovski, Ilana Levy
   Ben-Arye, Eran
   Bonucci, Massimo
TI Conceptualizing an Integrative Multiple Myeloma Care: The Role of
   Nutrition, Supplements, and Complementary Modalities
SO NUTRIENTS
LA English
DT Review
DE Multiple Myeloma; nutrition; acupuncture; vitamin D; supplementation;
   integrative medicine
ID INDUCED PERIPHERAL NEUROPATHY; STEM-CELL TRANSPLANTATION; VITAMIN-D
   DEFICIENCY; QUALITY-OF-LIFE; IN-VITRO; ANTITUMOR-ACTIVITY; PAIN
   MANAGEMENT; SYMPTOM BURDEN; CANCER PAIN; GREEN TEA
AB Multiple Myeloma (MM) is the second most prevalent hematologic malignancy, and its incidence has been increasing enormously in recent years. The prognosis of MM has changed radically with the introduction of new drugs that have improved life expectancy; recurrences are a common occurrence during the course of the disease and are characterized by an increase in refractory to treatment. Moreover, MM patients are challenged by quality of life-related concerns while limited conventional therapy may be offered. This includes bone pain and dialysis due to the complications of acute renal failure. We, therefore, believe that it is very important to add new treatment modalities, including supplements, nutritional modifications, acupuncture, and mind-body therapies, with the goal of improving treatment tolerance, effectiveness, and patients' quality of life. Moreover, many patients use some of these supplements on their own, in the hope of reducing the side effects, so it is even more important to know their action and potential. The purpose of this review is to illustrate all these strategies potentially available to enrich our approach to this, to date, incurable disease.
C1 [Andreazzoli, Francesca] Versilias Hosp, Dept Hematol, Viale Aurelia 335, I-55049 Camaiore, Italy.
   [Yurkovski, Ilana Levy] Bnai Zion Med Ctr, Hematol Unit, IL-3339419 Haifa, Israel.
   [Yurkovski, Ilana Levy; Ben-Arye, Eran] Technion Israel Inst Technol, Rappaport Fac Med, IL-3109601 Haifa, Israel.
   [Yurkovski, Ilana Levy] Bnai Zion Med Ctr, Complementary & Integrat Med Serv, IL-3339419 Haifa, Israel.
   [Ben-Arye, Eran] Lin Carmel & Zebulun Med Ctr, Integrat Oncol Program, Oncol Serv, Clalit Hlth Serv, IL-3535152 Haifa, Israel.
   [Bonucci, Massimo] Artoi Fdn, Via Ludov Micara 73, I-00165 Rome, Italy.
C3 Bnai Zion Medical Center; Technion Israel Institute of Technology;
   Rappaport Faculty of Medicine; Bnai Zion Medical Center; Clalit Health
   Services
RP Andreazzoli, F (corresponding author), Versilias Hosp, Dept Hematol, Viale Aurelia 335, I-55049 Camaiore, Italy.; Yurkovski, IL (corresponding author), Bnai Zion Med Ctr, Hematol Unit, IL-3339419 Haifa, Israel.; Yurkovski, IL (corresponding author), Technion Israel Inst Technol, Rappaport Fac Med, IL-3109601 Haifa, Israel.; Yurkovski, IL (corresponding author), Bnai Zion Med Ctr, Complementary & Integrat Med Serv, IL-3339419 Haifa, Israel.
EM francescandreazzoli@gmail.com; ilana.e.levy@gmail.com;
   eranben@netvision.net.il; maxbonucci@artoi.it
RI ; BONUCCI, MASSIMO/AAB-2386-2020
OI Levy Yurkovski, Ilana/0000-0002-8923-1467; BONUCCI,
   MASSIMO/0000-0002-8245-8642; Ben-Arye, Eran/0000-0002-4058-3672
CR Allegra A, 2018, TOXICOL IN VITRO, V47, P186, DOI 10.1016/j.tiv.2017.12.001
   Bai QX, 2012, INT J MOL SCI, V13, P4831, DOI 10.3390/ijms13044831
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Bao T, 2012, MED ACUPUNCT, V24, P181, DOI 10.1089/acu.2011.0868
   Bashang H, 2020, BIOTECHNOL APPL BIOC, V67, P171, DOI 10.1002/bab.1836
   Bates D, 2017, BIOL BLOOD MARROW TR, V23, P1567, DOI 10.1016/j.bbmt.2017.05.015
   Ben-Arye E, 2022, CANCER-AM CANCER SOC, V128, P3641, DOI 10.1002/cncr.34422
   Bhardwaj A, 2007, BLOOD, V109, P2293, DOI 10.1182/blood-2006-02-003988
   Bharti AC, 2003, J IMMUNOL, V171, P3863, DOI 10.4049/jimmunol.171.7.3863
   Bieghs L, 2016, ONCOTARGET, V7, P48732, DOI 10.18632/oncotarget.8982
   Bilbao A, 2022, BMC MED, V20, DOI 10.1186/s12916-022-02459-1
   Bird Sarah Anne, 2019, Palliat Care Soc Pract, V13, p1178224219868235, DOI [10.1177/1178224219868235, 10.1177/1178224219868235]
   Bonucci M., 2017, Br. J. Res, V4, P6
   Brown LM, 2001, CANCER CAUSE CONTROL, V12, P117, DOI 10.1023/A:1008937901586
   Capitao C, 2022, SUPPORT CARE CANCER, V30, P3007, DOI 10.1007/s00520-021-06633-8
   Carlson LE, 2023, J CLIN ONCOL, V41, P4562, DOI 10.1200/JCO.23.00857
   Cenzer I, 2020, AGING CLIN EXP RES, V32, P1153, DOI 10.1007/s40520-019-01465-3
   Chen JQ, 2019, ONCOL LETT, V17, P1108, DOI 10.3892/ol.2018.9662
   clinicaltrials.gov, about us
   Coluzzi F, 2019, CANCERS, V11, DOI 10.3390/cancers11122037
   Cowan AJ, 2022, JAMA-J AM MED ASSOC, V327, P464, DOI 10.1001/jama.2022.0003
   Daris B, 2019, BOSNIAN J BASIC MED, V19, P14, DOI 10.17305/bjbms.2018.3532
   Deng G, 2020, MED ACUPUNCT, V32, P394, DOI 10.1089/acu.2020.1494
   Deng G, 2020, PAIN MED, V21, P636, DOI 10.1093/pm/pnz190
   Deng G, 2018, SUPPORT CARE CANCER, V26, P657, DOI 10.1007/s00520-017-3881-7
   Díaz LE, 2002, EUR J CLIN NUTR, V56, pS50, DOI 10.1038/sj.ejcn.1601486
   El Iskandarani S, 2023, ACUPUNCT MED, V41, P319, DOI 10.1177/09645284231181403
   Flamann Cindy, 2019, Oncotarget, V10, P10, DOI [10.18632/oncotarget.26531, 10.18632/oncotarget.26531]
   Fritschi L, 2004, CANCER EPIDEM BIOMAR, V13, P532
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Golden EB, 2009, BLOOD, V113, P5927, DOI 10.1182/blood-2008-07-171389
   Golombick T, 2012, AM J HEMATOL, V87, P455, DOI 10.1002/ajh.23159
   Golombick T, 2009, CLIN CANCER RES, V15, P5917, DOI 10.1158/1078-0432.CCR-08-2217
   Gomez-Bougie P, 2015, CANCER BIOL THER, V16, P60, DOI 10.4161/15384047.2014.986997
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   Hosgood HD, 2007, CANCER CAUSE CONTROL, V18, P1065, DOI 10.1007/s10552-007-9047-z
   Huang L, 2021, J PAIN RES, V14, P343, DOI 10.2147/JPR.S292657
   Jakubikova J, 2011, HAEMATOL-HEMATOL J, V96, P1170, DOI 10.3324/haematol.2010.029363
   Jian XX, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00854-5
   Jogdand RP, 2022, Integrative Medicine Case Reports, V3, P25, DOI [10.38205/imcr.030125, 10.38205/imcr.030125, DOI 10.38205/IMCR.030125]
   Kamiya T, 2020, LEUKEMIA LYMPHOMA, V61, P1894, DOI 10.1080/10428194.2020.1749608
   Kayo T, 2024, J INTEGR COMPLEMENT, V30, P77, DOI 10.1089/jicm.2022.0710
   Ke MY, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.779562
   Key TJ, 2014, AM J CLIN NUTR, V100, p378S, DOI 10.3945/ajcn.113.071266
   Korde N, 2023, ECLINICALMEDICINE, V57, DOI 10.1016/j.eclinm.2023.101854
   Kutcher AM, 2022, WESTERN J NURS RES, V44, P169, DOI 10.1177/0193945921992538
   Kvam AK, 2015, HAEMATOLOGICA, V100, P704, DOI 10.3324/haematol.2015.127860
   Lamers J, 2013, PSYCHO-ONCOLOGY, V22, P2313, DOI 10.1002/pon.3284
   LeBlanc MR, 2023, JMIR CANCER, V9, DOI 10.2196/44533
   Lee DH, 2020, INT J CANCER, V147, P1823, DOI 10.1002/ijc.32928
   Li C, 2023, ANTI-CANCER AGENT ME, V23, P779, DOI 10.2174/1871520622666220905142338
   Ling FY, 2023, J PAIN RES, V16, P985, DOI 10.2147/JPR.S395421
   Liu TT, 2023, J ACUPUNCT TUINA SCI, V21, P51, DOI 10.1007/s11726-023-1358-4
   Lu WD, 2018, HEMATOL ONCOL CLIN N, V32, P519, DOI 10.1016/j.hoc.2018.01.009
   Lyu J, 2022, WOUNDS, V34, pE108, DOI 10.25270/wnds/21112
   Maier GS, 2015, ANTICANCER RES, V35, P6280
   Malik MA, 2022, BLOOD CANCER J, V12, DOI 10.1038/s41408-022-00666-w
   Mandiroglu S, 2014, ACUPUNCT MED, V32, P194, DOI 10.1136/acupmed-2013-010491
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Marques-Mourlet C, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1118691
   Mekkawy Sara A, 2022, Asian Pac J Cancer Prev, V23, P3507, DOI [10.31557/apjcp.2022.23.10.3507, 10.31557/APJCP.2022.23.10.3507]
   Mirhosseini N, 2023, CURR ONCOL, V30, P3263, DOI 10.3390/curroncol30030248
   Modernelli A, 2015, SCI REP-UK, V5, DOI 10.1038/srep15270
   Nabissi M, 2016, ONCOTARGET, V7, P77543, DOI 10.18632/oncotarget.12721
   Nakano A, 2011, INT J HEMATOL, V93, P727, DOI 10.1007/s12185-011-0850-7
   Ng AC, 2009, AM J HEMATOL, V84, P397, DOI 10.1002/ajh.21412
   Ng DLC, 2021, BMC PALLIAT CARE, V20, DOI 10.1186/s12904-021-00855-7
   O'Donnell EK, 2022, CANCER-AM CANCER SOC, V128, P1996, DOI 10.1002/cncr.34134
   Okolo O, 2023, COMPLEMENT THER MED, V73, DOI 10.1016/j.ctim.2023.102939
   Osborne TR, 2014, BMC CANCER, V14, DOI 10.1186/1471-2407-14-496
   Palumbo A, 2011, NEW ENGL J MED, V364, P1046, DOI 10.1056/NEJMra1011442
   Parolini C, 2019, MAR DRUGS, V17, DOI 10.3390/md17060374
   Pepeljugoski CA, 2019, BLOOD, V134, DOI 10.1182/blood-2019-130643
   Perrone G, 2009, LEUKEMIA, V23, P1679, DOI 10.1038/leu.2009.83
   Pianko MJ, 2019, BLOOD ADV, V3, P2040, DOI 10.1182/bloodadvances.2019032276
   Popat R, 2013, BRIT J HAEMATOL, V160, P714, DOI 10.1111/bjh.12154
   Pulgar A, 2012, BEHAV MED, V38, P12, DOI 10.1080/08964289.2011.647118
   Qiu X, 2022, ADV CLIN EXP MED, V31, P789, DOI 10.17219/acem/147268
   Ramakrishna R, 2020, CLIN CASE REP, V8, P739, DOI 10.1002/ccr3.2735
   Raoufinejad K, 2019, DARU, V27, P709, DOI 10.1007/s40199-019-00306-y
   Richardson PG, 2006, J CLIN ONCOL, V24, P3113, DOI 10.1200/JCO.2005.04.7779
   Roydhouse JK, 2019, BLOOD, V134, DOI 10.1182/blood-2019-124168
   Rui HB, 2020, J CELL BIOCHEM, V121, P224, DOI 10.1002/jcb.29135
   Saha V, 2022, INDIAN J CANCER, V59, P128, DOI 10.4103/ijc.IJC_1208_20
   Santo L, 2019, INT J CANCER, V144, P43, DOI 10.1002/ijc.31648
   Santosa D, 2022, CASP J INTERN MED, V13, P375, DOI [10.22088/cjim.13.2.9, 10.22088/cjim.13.2.375]
   Shah UA, 2023, LEUKEMIA, V37, P964, DOI 10.1038/s41375-023-01874-4
   Shah UA, 2022, CLIN CANCER RES, V28, P5149, DOI 10.1158/1078-0432.CCR-22-0723
   Shammas MA, 2006, BLOOD, V108, P2804, DOI 10.1182/blood-2006-05-022814
   Shapiro YN, 2021, BLOOD CANCER J, V11, DOI 10.1038/s41408-021-00560-x
   Sherman AC, 2009, J BEHAV MED, V32, P118, DOI 10.1007/s10865-008-9179-y
   Sung B, 2009, MOL CANCER THER, V8, P959, DOI 10.1158/1535-7163.MCT-08-0905
   Takeoka Y, 2016, CL LYMPH MYELOM LEUK, V16, P434, DOI 10.1016/j.clml.2016.04.010
   Thordardottir M, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206047
   van Gorkom GNY, 2022, NUTRIENTS, V14, DOI 10.3390/nu14224784
   Vlajinac HD, 2003, NEOPLASMA, V50, P79
   Wang J, 2016, SUPPORT CARE CANCER, V24, P3105, DOI 10.1007/s00520-016-3126-1
   Wang L, 2022, J Clin Med Pract, V26, P28, DOI DOI 10.7619/JCMP.20212712
   Wang Q, 2009, ACTA BIOCH BIOPH SIN, V41, P1018, DOI 10.1093/abbs/gmp094
   Wang YZ, 2015, CANCER CAUSE CONTROL, V26, P1307, DOI 10.1007/s10552-015-0625-1
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
   Yu CC, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.818179
   Zaidi Abbas, 2017, BMJ Case Rep, V2017, DOI 10.1136/bcr-2016-218148
   Zaleta AK, 2020, J NATL COMPR CANC NE, V18, P1087, DOI 10.6004/jnccn.2020.7561
   Zhang BQ, 2019, MED SCI MONITOR, V25, P8269, DOI 10.12659/MSM.919988
   Zhi WI, 2018, INTEGR CANCER THER, V17, P1079, DOI 10.1177/1534735418788667
   Zhou CG, 2018, EUR REV MED PHARMACO, V22, P2093, DOI 10.26355/eurrev_201804_14742
   Zhu GJ, 2023, BBA-REV CANCER, V1878, DOI 10.1016/j.bbcan.2023.188959
   Zoi V, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9091086
NR 109
TC 3
Z9 3
U1 3
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2024
VL 16
IS 2
AR 237
DI 10.3390/nu16020237
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GE1E0
UT WOS:001150890000001
PM 38257130
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tai, JB
   Hong, L
   Ma, ME
   Xu, J
   Fang, JQ
   Jiang, YQ
AF Tai, Jia-Bin
   Hong, Liang
   Ma, Meng-En
   Xu, Jia
   Fang, Jian-Qiao
   Jiang, Yi-Qian
TI Evaluation of therapeutic effect of transcutaneous electrical acupoint
   stimulation on bone metastasis pain and its influence on immune function
   of patients
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Article
DE Transcutaneous acupoint electrical stimulation; cancerous pain; tumor;
   immunity; clinical research
ID ACUPUNCTURE
AB Background: This study aimed to observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on bone metastasis pain, anxiety and immune function in cancer patients.
   Methods: A total of 127 patients with bone metastasis pain from malignant tumors were treated with TEAS or drugs. The TEAS group comprised of 62 patients, while the drug control group comprised of 65 patients. The differences in general indexes, baseline pain and anxiety between these two groups were not statistically significant.
   Results: Compared with those before treatment, the visual analog scale (VAS) scores of patients in the TEAS group and drug control group decreased after treatment, and the differences were statistically significant. The degrees of pain relief after treatment were similar between the two groups. Anxiety improved in both the TEAS group and drug control group, and the difference between these two groups was not statistically significant. The differences in immune indexes, B cell and CD8 between the TEAS group and drug control group were statistically significant. TEAS treatment could improve the declining trend of CD8 in patients.
   Conclusions: TEAS treatment and drug treatment can effectively alleviate mild to moderate pain in patients, and the efficacy of these two groups is similar. The treatment for moderate and severe pain needs to be combined with drug treatment to achieve a control effect. TEAS can improve the anxiety and immune function of patients, and prevent the decrease in B cells and CD8 in patients treated with drugs alone.
C1 [Tai, Jia-Bin; Hong, Liang; Ma, Meng-En; Xu, Jia; Jiang, Yi-Qian] Hangzhou Normal Univ, Internal Med Oncol, Xiaoshan Hosp 1, Med Coll, 199 Shixin South Rd, Hangzhou 311200, Peoples R China.
   [Fang, Jian-Qiao] Zhejiang Univ Tradit Chinese Med, Hangzhou, Peoples R China.
C3 Hangzhou Normal University; Zhejiang Chinese Medical University
RP Jiang, YQ (corresponding author), Hangzhou Normal Univ, Internal Med Oncol, Xiaoshan Hosp 1, Med Coll, 199 Shixin South Rd, Hangzhou 311200, Peoples R China.
EM yiqian9988@163.com
RI ; Jiang, Yiqian/H-8918-2018
OI Fang, Jianqiao/0000-0002-5155-8544; 
FU Hangzhou Science and technology project [20150633B53, 20171226Y82];
   Hangzhou Health Planning Project [2017B16]
FX Hangzhou Science and technology project (No.20150633B53; No.
   20171226Y82) and Hangzhou Health Planning Project (No.2017B16).
CR D'Alessandro EG, 2022, BMJ SUPPORT PALLIAT, V12, P64, DOI 10.1136/bmjspcare-2018-001542
   Deng G, 2020, PAIN MED, V21, P636, DOI 10.1093/pm/pnz190
   Deng G, 2018, ONCOLOGY-NY, V32, P310
   Garland SN, 2019, JNCI-J NATL CANCER I, V111, P1323, DOI 10.1093/jnci/djz050
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Keilani M, 2019, WIEN KLIN WOCHENSCHR, V131, P567, DOI 10.1007/s00508-019-1524-3
   Kerai S, 2014, INDIAN J ANAESTH, V58, P388, DOI 10.4103/0019-5049.138966
   Kim TH, 2019, ACUPUNCT MED, V37, P164, DOI 10.1177/0964528419832610
   Li K, 2019, CURR ONCOL, V26, pE147, DOI 10.3747/co.26.4261
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Guzmán RMMAY, 2019, COMPLEMENT THER CLIN, V36, P56, DOI 10.1016/j.ctcp.2019.05.003
   Shi Ren-Yi, 2019, Zhen Ci Yan Jiu, V44, P161, DOI 10.13702/j.1000-0607.180635
   Sivanesan E, 2019, REGION ANESTH PAIN M, V44, P615, DOI 10.1136/rapm-2019-100488
   Wang JS, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019540
   Wu LL, 2017, J TRADIT CHIN MED, V37, P629
   Zayan K, 2020, NEUROMODULATION, V23, P871, DOI 10.1111/ner.13146
   Zhang CP, 2020, CHIN MED-UK, V15, DOI 10.1186/s13020-020-0289-y
NR 17
TC 9
Z9 12
U1 1
U2 20
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD SEP
PY 2020
VL 9
IS 5
BP 2538
EP 2544
DI 10.21037/apm-19-434
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA NY8YP
UT WOS:000576670500013
PM 32954744
OA gold
DA 2026-01-16
ER

PT J
AU Chou, YH
   Yeh, ML
   Huang, ZS
   Hsu, HD
AF Chou, Ya-Hui
   Yeh, Mei-Ling
   Huang, Tzu-Shin
   Hsu, Hedi
TI Acupoint stimulation improves pain and quality of life in head and neck
   cancer patients with chemoradiotherapy: A randomized controlled trial
SO ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING
LA English
DT Article
DE Acupoint stimulation; Head and neck cancer; Chemoradiotherapy; Pain;
   Quality of life
ID ACUPUNCTURE; RADIOTHERAPY; MANAGEMENT; MUCOSITIS; SYMPTOMS; TOXICITY;
   DISTRESS; ANXIETY
AB Objective: This study aimed to evaluate the effect of acupoint stimulation on pain, negative moods, and quality of life for head and neck cancer (HNC) patients who underwent concurrent chemoradiotherapy (CCRT).Methods: This randomized controlled trial recruited participants from a medical center and randomly assigned using a permuted block randomization list with computer-generated random serial numbers into the AcuCare group (n = 46) receiving acupoint stimulation with transcutaneous acupoint electrical stimulation (TAES) and auricular acupressure (AA) or the control group (n = 46) without any acupoint stimulation. Outcomes were repeatedly assessed pain intensity using the visual analogue scale, negative moods using the hospital anxiety and depression scale, and quality of life (QoL) using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck 35.Results: After adjusting varying mucositis grades and time-dependent growth effects, the generalized estimating equations showed a significantly increase in pain intensity at weeks 1, 2, 3, and 6 (P < 0.05), but not in negative moods (P > 0.05), compared to baseline and control group. Analysis of covariance showed a significant group difference in the senses problems of QoL (F = 7.33, P = 0.01) at Week 6.Conclusions: This study supports that acupoint stimulation could effectively reduce pain and improve senses problem of QoL for patients with HNC. Trial registration: This study was registered at https://clinicaltrials.gov/NCT03640195.
C1 [Chou, Ya-Hui] Natl Taipei Univ Nursing & Hlth Sci, Dept Nursing, Taoyuan Chang Gung Mem Hosp, Taoyuan, Taiwan.
   [Chou, Ya-Hui; Yeh, Mei-Ling; Hsu, Hedi] Natl Taipei Univ Nursing & Hlth Sci, Sch Nursing, Taoyuan, Taiwan.
   [Huang, Tzu-Shin] Taoyuan Chang Gung Mem Hosp, Dept Nursing, Taoyuan, Taiwan.
C3 National Taipei University of Nursing & Health Science (NTUNHS); Chang
   Gung Memorial Hospital; National Taipei University of Nursing & Health
   Science (NTUNHS); Chang Gung Memorial Hospital
RP Yeh, ML (corresponding author), Natl Taipei Univ Nursing & Hlth Sci, Sch Nursing, Taoyuan, Taiwan.
EM meiling@ntunhs.edu.tw
OI Yeh, Mei-Ling/0000-0002-2934-4283
FU Chang Gung Memorial Hospital of Taiwan [CMRPG5F0131]
FX This study was supported by the grant from the Chang Gung Memorial
   Hospital of Taiwan (Grant No.CMRPG5F0131).
CR Akazawa K, 2018, J LARYNGOL OTOL, V132, P111, DOI [10.1017/S0022215118000014, 10.1017/s0022215118000014]
   Allen-Ayodabo CO, 2019, ORAL ONCOL, V99, DOI 10.1016/j.oraloncology.2019.09.026
   [Anonymous], 2014, Auriculotherapy Manual: Chinese and Western Systems of Ear Acupuncture
   Bjordal K, 1999, J CLIN ONCOL, V17, P1008, DOI 10.1200/JCO.1999.17.3.1008
   Bossi P, 2020, SUPPORT CARE CANCER, V28, P451, DOI 10.1007/s00520-019-05147-8
   Bottomley A, 2014, CANCER-AM CANCER SOC, V120, P390, DOI 10.1002/cncr.28392
   Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21609, 10.3322/caac.21492]
   Chiou YF, 2020, REHABIL NURS, V45, P225, DOI 10.1097/RNJ.0000000000000198
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Colevas AD, 2018, J NATL COMPR CANC NE, V16, P479, DOI 10.6004/jnccn.2018.0026
   Cramer H, 2016, MEDICINE, V95, P2901
   Cramer JD, 2018, OTOLARYNG HEAD NECK, V159, P853, DOI 10.1177/0194599818783964
   Dymackova R, 2020, BIOMED PAP, V164, P454, DOI 10.5507/bp.2020.021
   Epstein JB, 2019, J NATL CANCER INST M, V53
   Epstein JB, 2020, SUPPORT CARE CANCER, V28, P4305, DOI 10.1007/s00520-019-05232-y
   Gavronsky S, 2012, PAIN MANAG NURS, V13, P150, DOI 10.1016/j.pmn.2009.08.001
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Health Promotion Administration Ministry of Health and Welfare, 2017, Cancer Registry Annual Report
   Holländer-Mieritz C, 2019, ACTA ONCOL, V58, P603, DOI 10.1080/0284186X.2018.1563713
   Hou PW, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/495684
   Hu CQ, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1720239
   Hu YQ, 2017, IRAN J PUBLIC HEALTH, V46, P1054
   Hura N, 2020, INT FORUM ALLERGY RH, V10, P1065, DOI 10.1002/alr.22624
   Iqbal MS, 2017, INT ARCH OTORHINOLAR, V21, P171
   Jacobs JM, 2019, J NATL COMPR CANC NE, V17, P221, DOI 10.6004/jnccn.2018.7098
   Jiang JR, 2019, J CLIN ONCOL, V37, P135, DOI 10.1200/JCO.18.00896
   Kim K, 2018, INTEGR CANCER THER, V17, P1137, DOI 10.1177/1534735418786797
   Lopez-Vaquero D, 2017, MOL CLIN ONCOL, V6, P931, DOI 10.3892/mco.2017.1238
   Chien CHYLC, 2015, Journal of Pain & Relief, V04, DOI 10.4172/2167-0846.1000199
   Melo Andressa Lais Salvador de, 2014, Fisioter. mov., V27, P495, DOI 10.1590/0103-5150.027.004.AO01
   Michelson Michelle, 2018, Evid Based Dent, V19, P60, DOI [10.1038/sj.ebd.6401312, 10.1038/sj.ebd.6401312]
   Mohammed N, 2018, J. Compl. Integr. Med., V15
   Muzumder S, 2018, INDIAN J PALLIAT CAR, V24, P176, DOI 10.4103/IJPC.IJPC_145_17
   Nayak SG, 2019, J CANCER RES THER, V15, P638, DOI 10.4103/jcrt.JCRT_1123_16
   Oh B, 2018, INTEGR CANCER THER, V17, P458, DOI 10.1177/1534735417734912
   Paley CA, 2015, COCHRANE DB SYST REV, V2015
   Paley CA, 2017, PAIN MANAG, V7, P345, DOI 10.2217/pmt-2017-0018
   Polverini PJ, 2019, J DENT RES, V98, P489, DOI 10.1177/0022034519833645
   Romero-Reyes M, 2016, PATOLOG A ORAL CIRUG, V21, P665
   Rosenthal DI, 2014, CANCER-AM CANCER SOC, V120, P1975, DOI 10.1002/cncr.28672
   Ruela LD, 2018, REV ESC ENFERM USP, V52, DOI [10.1590/S1980-220X2017040503402, 10.1590/s1980-220x2017040503402]
   Sendlbeck M, 2015, RMD OPEN, V1, DOI 10.1136/rmdopen-2015-000140
   Tao WW, 2015, ONCOTARGET, V6, P39725, DOI 10.18632/oncotarget.5388
   Vallim ETA, 2018, GLOB SURG, V4, P1
   van Beek FE, 2020, ORAL ONCOL, V102, DOI 10.1016/j.oraloncology.2020.104576
   Villa A, 2015, CURR OPIN ONCOL, V27, P159, DOI 10.1097/CCO.0000000000000180
   Vodermaier A, 2009, JNCI-J NATL CANCER I, V101, P1464, DOI 10.1093/jnci/djp336
   Wang T, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/5645632
   WHO Regional Office for the Western Pacific, 2008, WHO STAND AC POINT L
   Yang DY, 2019, INT J NURS SCI, V6, P278, DOI 10.1016/j.ijnss.2019.05.006
   Yang YL, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/1618767
   Yeh CH., 2014, J Pain Relief, DOI DOI 10.4172/2167-0846.1000139
   Yeh ML, 2018, CLIN NURS RES, V27, P450, DOI 10.1177/1054773816685745
   Yeh ML, 2010, ALTERN THER HEALTH M, V16, P10
   Yeh ML, 2004, CONTEMMPORARY MERIDI
   Yeh ML, 2020, Traditional Chinese medicine in nursing care, V3rd
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
   Zimmaro LA, 2018, CANCER-AM CANCER SOC, V124, P1053, DOI 10.1002/cncr.31109
NR 58
TC 6
Z9 6
U1 2
U2 25
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2347-5625
EI 2349-6673
J9 ASIA-PAC J ONCOL NUR
JI Asia-Pac. J. Oncol. Nurs.
PD JAN
PY 2022
VL 9
IS 1
BP 61
EP 68
DI 10.1016/j.apjon.2021.11.002
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 1D0UW
UT WOS:000793526200011
PM 35528798
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, G
   Zhang, CX
   Wang, CY
   Xiao, L
AF Li, Gang
   Zhang, Changxi
   Wang, Congyi
   Xiao, Ling
TI Acupuncture against chronic postsurgical pain in non-small cell lung
   cancer patients A protocol of randomized controlled trial
SO MEDICINE
LA English
DT Article
DE acupuncture; lung cancer; pain; video-assisted thoracoscopic lobectomy
ID ASSISTED THORACOSCOPIC LOBECTOMY; EARLY-STAGE; THORACOTOMY; PREVALENCE;
   THERAPY
AB Introduction: Video-assisted thoracoscopic lobectomy is the prior recommended treatment for non-small cell lung cancer (NSCLC), with the advantages of small trauma, less postoperative pain, and quick recovery. However, a large number of patients may suffer chronic postsurgical pain (CPSP), which makes the patients unwilling to practice pulmonary exercises, and it would directly affect patient's cough, sputum expectoration, and mobility. Opioids could greatly improve the quality of postoperative analgesia and the quality of life after surgery, but it is accompanied with obvious side effects. A number of clinical studies have proved that acupuncture could improve postoperative pain and reduce opioid use. In this study, we try to conduct a randomized controlled study to evaluate the efficacy and safety of plum-blossom needle acupuncture combined with Tramadol in improving CPSP after lobectomy in NSCLC patients. Methods: Patients will be randomly divided into treatment group (acupuncture plus Tramadol) and control group (sham acupuncture plus Tramadol) with a random number table in 1:1 ratio. The patients, outcome assessor, and statistician will be blinded. The outcomes are changes of numerical rating scale, Karnofsky performance score, brief pain inventory, blood routine, liver and kidney function. The data will be analyzed by SPSS 22.0. Conclusions: The results will help to evaluate the efficacy and safety of plum-blossom needle acupuncture in improving CPSP after lobectomy in NSCLC patients.
C1 [Li, Gang; Zhang, Changxi; Wang, Congyi; Xiao, Ling] Chongqing Steel Gen Hosp, Dept Thorac Surg, Chongqing, Peoples R China.
RP Li, G (corresponding author), Chongqing Steel Gen Hosp, 1 Dayan Sancun, Chongqing 400081, Peoples R China.
EM lg19771022@163.com
RI Wang, CongYi/MTC-8798-2025
FU Research Fund Projects of Chinese Universities [0020110456]
FX This work is supported by the Research Fund Projects of Chinese
   Universities (No. 0020110456).
CR Bendixen M, 2016, LANCET ONCOL, V17, P836, DOI 10.1016/S1470-2045(16)00173-X
   Dell'Amore A, 2022, SURG ENDOSC, V36, P1466, DOI 10.1007/s00464-021-08431-z
   Deng HY, 2021, WORLD J SURG, V45, P897, DOI 10.1007/s00268-020-05877-5
   Dong BQ, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.585709
   Dziedzic DA, 2021, J THORAC DIS, V13, P101, DOI 10.21037/jtd-20-2251
   Grosen K, 2013, EUR J CARDIO-THORAC, V43, P95, DOI 10.1093/ejcts/ezs159
   Gullo R, 2021, MINERVA SURG, V76, P80, DOI 10.23736/S2724-5691.20.08395-9
   Hirai K, 2019, J THORAC DIS, V11, P3896, DOI 10.21037/jtd.2019.09.07
   Li QY, 2020, ANN PALLIAT MED, V9, P1030, DOI 10.21037/apm-20-909
   Liang Q, 2020, AM J CHINESE MED, V48, P1769, DOI 10.1142/S0192415X20500883
   Liu CC, 2021, CHINESE J CANCER RES, V33, P79, DOI 10.21147/j.issn.1000-9604.2021.01.09
   Liu Y, 2021, CANCER MANAG RES, V13, P2447, DOI 10.2147/CMAR.S282617
   Magouliotis DE, 2021, LUNG, V199, P43, DOI 10.1007/s00408-020-00411-9
   Porrello C, 2019, G CHIR, V40, P115
   Sato A, 2021, BMC CANCER, V21, DOI 10.1186/s12885-021-08011-3
   Sihoe ADL, 2020, RESPIROLOGY, V25, P49, DOI 10.1111/resp.13920
   Sun Y, 2008, BRIT J ANAESTH, V101, P151, DOI 10.1093/bja/aen146
   Wu MS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150367
   Yamashita Y, 2013, EUR J CARDIO-THORAC, V44, pE71, DOI 10.1093/ejcts/ezt107
   Yao J, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000022719
   Yun JK, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-72272-4
NR 21
TC 9
Z9 10
U1 5
U2 26
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 8
PY 2021
VL 100
IS 40
AR e27461
DI 10.1097/MD.0000000000027461
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WC2CZ
UT WOS:000704071200040
PM 34622872
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lee, JH
   Gang, J
   Yang, E
   Kim, W
   Jin, YH
AF Lee, Ji Hwan
   Gang, Juan
   Yang, Eunhee
   Kim, Woojin
   Jin, Young-Ho
TI Bee Venom Acupuncture Attenuates Oxaliplatin-Induced Neuropathic Pain by
   Modulating Action Potential Threshold in A-Fiber Dorsal Root Ganglia
   Neurons
SO TOXINS
LA English
DT Article
DE action potential; allodynia; bee venom acupuncture; oxaliplatin;
   voltage-gated sodium channel
ID SODIUM-CHANNELS; PERIPHERAL NEUROPATHY; ANTICANCER DRUG; NEUROTOXICITY;
   MECHANISMS; PREVENTION; MANAGEMENT; CISPLATIN; MODEL; NA+
AB Oxaliplatin is a third-generation platinum-based chemotherapeutic drug widely used in colorectal cancer treatment. Although potent against this tumor, it can induce cold and mechanical allodynia even after a single injection. The currently used drugs to attenuate this allodynia can also cause unwanted effects, which limit their use. Bee venom acupuncture (BVA) is widely used in Korean medicine to treat pain. Although the effect of BVA on oxaliplatin-induced neuropathic pain has been addressed in many studies, its action on dorsal root ganglia (DRG) neurons has never been investigated. A single oxaliplatin injection (6 mg/kg, intraperitoneally) induced cold and mechanical allodynia, and BVA (0.1 and 1 mg/kg, subcutaneous, ST36) dose-dependently decreased allodynia in rats. On acutely dissociated lumbar 4-6 DRG neurons, 10 min application of oxaliplatin (100 mu M) shifted the voltage-dependence of sodium conductance toward negative membrane potentials in A- but not C-fibers. The resting membrane potential remained unchanged, but the action potential threshold decreased significantly compared to that of the control (p < 0.05). However, 0.1 mu g/mL of BVA administration increased the lowered action potential threshold. In conclusion, these results suggest that BVA may attenuate oxaliplatin-induced neuropathic pain by altering the action potential threshold in A-fiber DRG neurons.
C1 [Lee, Ji Hwan; Kim, Woojin] Kyung Hee Univ, Coll Korean Med, Dept Physiol, Seoul 02453, South Korea.
   [Lee, Ji Hwan; Kim, Woojin] Kyung Hee Univ, Grad Sch, Dept Sci Korean Med, Seoul 02453, South Korea.
   [Gang, Juan; Kim, Woojin] Kyung Hee Univ, Grad Sch, Dept East West Med, Seoul 02453, South Korea.
   [Yang, Eunhee; Jin, Young-Ho] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul 02453, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University; Kyung
   Hee University
RP Kim, W (corresponding author), Kyung Hee Univ, Coll Korean Med, Dept Physiol, Seoul 02453, South Korea.; Kim, W (corresponding author), Kyung Hee Univ, Grad Sch, Dept Sci Korean Med, Seoul 02453, South Korea.; Kim, W (corresponding author), Kyung Hee Univ, Grad Sch, Dept East West Med, Seoul 02453, South Korea.; Jin, YH (corresponding author), Kyung Hee Univ, Coll Med, Dept Physiol, Seoul 02453, South Korea.
EM mibdna@khu.ac.kr; khan2296@naver.com; dmsgmls317@gmail.com;
   wjkim@khu.ac.kr; jinyh@khu.ac.kr
RI ; Kim, Woojin/AAK-2464-2020
OI Lee, Ji Hwan/0000-0001-9572-6864; Kim, Woojin/0000-0001-8494-4524
FU National Research Foundation of Korea (NRF) - Korea government (Ministry
   of Science and Information and Communications Technology; MSIT)
   [2020R1A5A201941311]; Immune and Pain Society
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (Ministry of Science and
   Information and Communications Technology; MSIT) (no.
   2020R1A5A201941311) and by a grant from the Immune and Pain Society.
CR Adelsberger H, 2000, EUR J PHARMACOL, V406, P25, DOI 10.1016/S0014-2999(00)00667-1
   Andre T, 2004, NEW ENGL J MED, V350, P2343, DOI 10.1056/NEJMoa032709
   Bennett DL, 2019, PHYSIOL REV, V99, P1079, DOI 10.1152/physrev.00052.2017
   Benoit E, 2006, GEN PHYSIOL BIOPHYS, V25, P263
   Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21609, 10.3322/caac.21492]
   Cavaletti G, 2001, EUR J CANCER, V37, P2457, DOI 10.1016/S0959-8049(01)00300-8
   Cersosimo RJ, 2005, ANN PHARMACOTHER, V39, P128, DOI 10.1345/aph.1E319
   Chae HK, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020432
   Choi J, 2017, TOXINS, V9, DOI 10.3390/toxins9110351
   Choi S, 2019, TOXINS, V11, DOI 10.3390/toxins11070396
   Cummins TR, 2007, PAIN, V131, P243, DOI 10.1016/j.pain.2007.07.026
   Deuis JR, 2013, PAIN, V154, P1749, DOI 10.1016/j.pain.2013.05.032
   Eckel F, 2002, DEUT MED WOCHENSCHR, V127, P78, DOI 10.1055/s-2002-19594
   Farshchian N, 2018, CANCER CHEMOTH PHARM, V82, P787, DOI 10.1007/s00280-018-3664-y
   Frot M, 2004, PAIN, V108, P230, DOI 10.1016/j.pain.2003.11.017
   Gamelin E, 2002, SEMIN ONCOL, V29, P21, DOI 10.1053/sonc.2002.35525
   GREGG RW, 1992, J CLIN ONCOL, V10, P795, DOI 10.1200/JCO.1992.10.5.795
   Hains BC, 2005, BRAIN, V128, P2359, DOI 10.1093/brain/awh623
   Heide R, 2018, CLIN NEUROPHYSIOL, V129, P694, DOI 10.1016/j.clinph.2017.11.015
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Horowitz Steven H, 2007, Anesthesiol Clin, V25, P699, DOI 10.1016/j.anclin.2007.07.010
   Jacobs S, 2010, CANCER CHEMOTH PHARM, V65, P817, DOI 10.1007/s00280-009-1085-7
   Jung Y, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1556-z
   Kagiava A, 2008, NEUROTOXICOLOGY, V29, P1100, DOI 10.1016/j.neuro.2008.09.005
   Kim C, 2016, MOLECULES, V21, DOI 10.3390/molecules21091253
   Kim MJ, 2017, KOREAN J PHYSIOL PHA, V21, P657, DOI 10.4196/kjpp.2017.21.6.657
   Kim W, 2020, PROCESSES, V8, DOI 10.3390/pr8060680
   Kim W, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122626
   Kim W, 2016, TOXINS, V8, DOI 10.3390/toxins8020033
   Lee Eun Joo, 2016, Neonatal medicine, V23, P43, DOI 10.5385/nm.2016.23.1.43
   Lee G, 2018, J PHARMACOL EXP THER, V367, P215, DOI 10.1124/jpet.118.251363
   Lee JD, 2005, EVID-BASED COMPL ALT, V2, P79, DOI 10.1093/ecam/neh070
   Lee JH, 2016, KOREAN J PHYSIOL PHA, V20, P407, DOI 10.4196/kjpp.2016.20.4.407
   Lee JH, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-471
   Lee MS, 2008, J PAIN, V9, P289, DOI 10.1016/j.jpain.2007.11.012
   Li D, 2016, TOXINS, V8, DOI 10.3390/toxins8010027
   Li D, 2015, TOXINS, V7, P2422, DOI 10.3390/toxins7072422
   Lim BS, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/369324
   Mannelli LD, 2017, NEUROPHARMACOLOGY, V121, P49, DOI 10.1016/j.neuropharm.2017.04.029
   Park SB, 2008, CURR MED CHEM, V15, P3081, DOI 10.2174/092986708786848569
   Rogers M, 2006, SEMIN CELL DEV BIOL, V17, P571, DOI 10.1016/j.semcdb.2006.10.009
   Shin BC, 2012, EUR J INTEGR MED, V4, pE271, DOI 10.1016/j.eujim.2012.02.005
   Sittl R, 2012, P NATL ACAD SCI USA, V109, P6704, DOI 10.1073/pnas.1118058109
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Son DJ, 2007, PHARMACOL THERAPEUT, V115, P246, DOI 10.1016/j.pharmthera.2007.04.004
   Song YL, 2018, J PHYSIOL BIOCHEM, V74, P207, DOI 10.1007/s13105-017-0606-9
   Soulie P, 1997, EUR J CANCER, V33, P1400, DOI 10.1016/S0959-8049(97)00122-6
   Wilson RH, 2002, J CLIN ONCOL, V20, P1767, DOI 10.1200/JCO.2002.07.056
   Yoon J, 2012, J ACUPUNCT MERIDIAN, V5, P156, DOI [10.1016/j.jams.2012.05.003, 10.106/j.jams.2012.05.003]
   Zhang S, 2018, TOXICON, V148, P64, DOI 10.1016/j.toxicon.2018.04.012
NR 50
TC 25
Z9 26
U1 2
U2 9
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6651
J9 TOXINS
JI Toxins
PD DEC
PY 2020
VL 12
IS 12
AR 737
DI 10.3390/toxins12120737
PG 13
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA PK3HB
UT WOS:000602339500001
PM 33255279
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Xu, JQ
   Zhang, Q
   Xue, N
   Zhang, C
   Xu, WR
AF Xu, Jinqun
   Zhang, Qing
   Xue, Na
   Zhang, Cui
   Xu, Weiru
TI The therapeutic effect of acupuncture in the treatment of
   chemotherapy-induced peripheral neuropathy: a randomized controlled
   trial
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE acupuncture; chemotherapy; peripheral neuropathy; therapeutic;
   randomized controlled trial
ID ELECTROACUPUNCTURE; PILOT; PAIN; PREVENTION; MANAGEMENT; NEEDLE
AB Introduction: Effective treatments for preventing and treating chemotherapy-induced peripheral neuropathy (CIPN) are still under exploration. Acupuncture in the treatment of CIPN requires more clinical trial data. This study aimed to evaluate the therapeutic effect of acupuncture on CIPN and explore its efficacy and safety in improving peripheral neuropathy. Methods: A randomized controlled trial was conducted from May 2021 to June 2023. Eligible patients were randomly divided into a verum acupuncture group and a sham acupuncture group at a 1:1 ratio with sealed opaque envelopes. The patients of both the two groups took oral mecobalamin tablets, 0.5 mg, three times a day for 2 weeks. Participants received acupuncture treatment three times a week for 2 weeks. The primary outcome was evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) 3.0. The secondary outcomes were assessed using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-CIPN twenty-item subscale (QLQ-CIPN20), Numerical Rating Scale (NRS), Traditional Chinese Medicine (TCM) syndrome score, and nerve conduction study (NCS) testing. Assessments were conducted at baseline, 1 week, and 2 weeks. Results: All 70 participants were recruited and randomized. In the end, 68 patients were included in the datasets and received verum acupuncture (n = 34) or sham acupuncture (n = 34). After 2 weeks of treatment and follow-up, a statistically significant difference was found in the NCI-CTCAE scores between the two groups (p = 0.02). Baseline-to-2-week assessment scores improved significantly in the intervention group (vs. controls) on EORTC QLQ-CIPN20 (p = 0.02), NRS scores (p = 0.03), TCM syndrome scores (p = 0.04), and sensory nerve action potential (SNAP) of median and peroneal nerves, sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) of peroneal nerves (p < 0.05). No serious adverse events were reported. Conclusion: This study supports the feasibility of acupuncture combined with medication as an intervention for patients with CIPN and confirms its efficacy and safety in improving peripheral neuropathy.
C1 [Xu, Jinqun; Zhang, Qing; Xue, Na; Zhang, Cui; Xu, Weiru] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing, Peoples R China.
   [Xu, Jinqun] Yibin Hosp Tradit Chinese Med, Dept Oncol, Yibin, Peoples R China.
C3 Capital Medical University
RP Xu, WR (corresponding author), Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing, Peoples R China.
EM xuweiru@bjzhongyi.com
RI ZHANG, QING/AGY-7972-2022
FU Beijing Municipal Administration of Hospitals Incubating Program
   [PZ2020019]; Beijing Municipal Administration of Hospitals' Youth
   Programme [QML20161001]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   grants from the Beijing Municipal Administration of Hospitals Incubating
   Program (grant number: PZ2020019) and the Beijing Municipal
   Administration of Hospitals' Youth Programme (grant number:
   QML20161001).
CR Abu Sharour L, 2021, APPL NEUROPSYCH-ADUL, V28, P614, DOI 10.1080/23279095.2019.1677232
   Bae EH, 2021, NEUROTHERAPEUTICS, V18, P2384, DOI 10.1007/s13311-021-01142-2
   Banach M, 2017, BRAIN BEHAV, V7, DOI 10.1002/brb3.558
   Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Ben-Horin I, 2017, INTEGR CANCER THER, V16, P258, DOI 10.1177/1534735417690254
   Brown TJ, 2019, JAMA ONCOL, V5, P750, DOI 10.1001/jamaoncol.2018.6771
   Cai YY, 2021, J PAIN SYMPTOM MANAG, V61, P305, DOI 10.1016/j.jpainsymman.2020.07.034
   Cao LC, 2024, FRONT ONCOL, V14, DOI 10.3389/fonc.2024.1326970
   Cavaletti G, 2013, ANN ONCOL, V24, P454, DOI 10.1093/annonc/mds329
   Cavaletti G, 2010, NAT REV NEUROL, V6, P657, DOI 10.1038/nrneurol.2010.160
   Choi JW, 2015, AM J CHINESE MED, V43, P57, DOI 10.1142/S0192415X15500044
   Dai L., 2019, Guangzhou Univ Chin Med, DOI DOI 10.27044/D.CNKI.GGZZU.2019.000473
   Desforges AD, 2022, BIOMED PHARMACOTHER, V147, DOI 10.1016/j.biopha.2022.112671
   DONOFRIO PD, 1990, MUSCLE NERVE, V13, P889, DOI 10.1002/mus.880131002
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Huo JG., 2023, Chin J Oncol Surg, V15, P521, DOI DOI 10.3969/J.ISSN.1674-4136.2023.06.001
   Iravani S, 2020, PAIN RES MANAG, V2020, DOI 10.1155/2020/2504674
   Jeong YJ, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/5367014
   Knoerl R, 2021, AM J NURS, V121, P26, DOI [10.1097/01.naj.0000742060.56042.e7, 10.1097/01.NAJ.0000742060.56042.e7]
   Kutcher AM, 2022, WESTERN J NURS RES, V44, P169, DOI 10.1177/0193945921992538
   Li XJ, 2024, FRONT ONCOL, V14, DOI 10.3389/fonc.2024.1440205
   Li YY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235917
   Linbo L., 2024, Chin J Clin Oncol Rehabil, V31, P561, DOI DOI 10.13455/J.CNKI.CJCOR.113494-2024-2024-0167
   Litscher G, 2005, FORSCH KOMP KLAS NAT, V12, P190, DOI 10.1159/000087044
   Litscher G, 2002, LASER MED SCI, V17, P19, DOI 10.1007/s10103-002-8262-9
   Loprinzi CL, 2020, J CLIN ONCOL, V38, DOI 10.1200/JCO.20.01399
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Lu WD, 2012, MED ACUPUNCT, V24, P233, DOI 10.1089/acu.2012.0904
   Ma F, 2020, CHIN J FRONT MED SCI, V12, P41, DOI [DOI 10.12037/YXQY.2020.03-07, 10.12037/YXQY.2020.03-07]
   Meng XZ, 2011, BRAIN RES, V1414, P58, DOI 10.1016/j.brainres.2011.08.004
   Molassiotis A, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419836501
   National Medical Products Administration, Guidelines for clinical research of new traditional chinese medicine drugs for syndrome patterns
   Pike Crystal T, 2012, Chemother Res Pract, V2012, P913848, DOI 10.1155/2012/913848
   Pu T, 2023, FRONT NEUROSCI-SWITZ, V17, DOI 10.3389/fnins.2023.1156308
   Rattanakrong Nida, 2022, Asian Pac J Cancer Prev, V23, P1547, DOI [10.31557/apjcp.2022.23.5.1547, 10.31557/APJCP.2022.23.5.1547]
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Schwab L, 2023, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.1005083
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Staff NP, 2017, ANN NEUROL, V81, P772, DOI 10.1002/ana.24951
   Stillman Mark, 2006, Curr Pain Headache Rep, V10, P279
   Stubblefield MD, 2009, J NATL COMPR CANC NE, V7, pS1, DOI 10.6004/jnccn.2009.0078
   Valentini J, 2024, FRONT MED-LAUSANNE, V11, DOI 10.3389/fmed.2024.1371056
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Weiru X., 2022, J Guangzhou Univ Traditional Chin Med, V39, P24, DOI DOI 10.13359/J.CNKI.GZXBTCM.2022.01.005
   Xu Wei-Ru, 2010, Zhongguo Zhen Jiu, V30, P457
   Yuan Y., 2024, WORLD CHINESE MED, V19, P1348, DOI DOI 10.3969/J.ISSN.1673-7202.2024.09.023
   Zhang Y, 2018, EUR J PAIN, V22, P679, DOI 10.1002/ejp.1132
   Zhao L, 2017, JAMA INTERN MED, V177, P508, DOI 10.1001/jamainternmed.2016.9378
   Zhao XM, 2019, PHYSIOL RES, V68, P501, DOI 10.33549/physiolres.934084
NR 50
TC 0
Z9 0
U1 8
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD APR 16
PY 2025
VL 15
AR 1500410
DI 10.3389/fonc.2025.1500410
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 2BR2N
UT WOS:001478822500001
PM 40308502
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Hübner, J
AF Huebner, J.
TI Update 2013 on complementary oncology
SO ONKOLOGE
LA German
DT Article
DE Complementary oncology; Vitamin D; Selenium; Acupuncture; Mistleto
ID CELL LUNG-CANCER; QUALITY-OF-LIFE; BREAST-CANCER; PROSTATE-CANCER;
   DOUBLE-BLIND; INDUCED XEROSTOMIA; CLINICAL-TRIAL; NECK-CANCER;
   FOLIC-ACID; VITAMIN-C
AB In 2012 several studies and reviews on the question of prevention of tumerous diseases with nutritional supplements were published. There are still no indications for the use of antioxidants in healthy people. Folic acid and Vitamin B12 even may induce tumor growth. The data underline the significance of Vitamin D in primary and secondary prevention. Selenium levels below as well as above normal are associated with a higher risk of cancer. Omega-3 fatty acids have a potential as anti-inflammatory agents. The results of two studies are indicative for pomegranate extract reducing growth in prostate cancer but in both studies a control group without extract was lacking. So far no study on mistletoe has been published which proves positive effects on survival or side effects of cancer therapy. Chinese medical herbs may contain interesting substances. As knowledge on the side effects and interactions is missing they should not be used outside studies. For acupuncture many studies have been published but the quality in general is low so that no conclusions can be drawn concerning pain, fatigue and xerostomia. Systematic reviews have cited positive results for nausea and emesis. No studies are available which show results demonstrating the efficacy of homeopathy in cancer patients.
C1 Goethe Univ Frankfurt, Dr Senckenberg Chronomed Inst, D-60590 Frankfurt, Germany.
C3 Goethe University Frankfurt
RP Hübner, J (corresponding author), Goethe Univ Frankfurt, Dr Senckenberg Chronomed Inst, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
EM Huebner@med.uni-frankfurt.de
RI HÃ¼bner, Jutta/AAY-5396-2020
CR [Anonymous], COCHRANE DATABASE SY
   [Anonymous], COCHRANE DATABASE SY
   Attia A, 2012, J NEURO-ONCOL, V109, P357, DOI 10.1007/s11060-012-0901-9
   Bar-Sela G, 2012, EUR J CANCER, DOI [10.1016/i, DOI 10.1016/J]
   Barton DL, 2012, SUPPORT CARE CANC
   Chajès V, 2012, CANCER EPIDEM BIOMAR, V21, P319, DOI 10.1158/1055-9965.EPI-11-0896
   Cho JH, 2008, J ALTERN COMPLEM MED, V14, P523, DOI 10.1089/acm.2007.0793
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Chua ME, 2012, PROSTATE CANCER-US, V2012, DOI 10.1155/2012/826254
   Clapin HF, 2012, NUTR CANCER, V64, P937, DOI 10.1080/01635581.2012.715718
   Cortés-Jofré M, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002141.pub2
   Crowther M, 2009, BONE MARROW TRANSPL, V44, P413, DOI 10.1038/bmt.2009.41
   Cruciani RA, 2012, J CLIN ONCOL, V30, P3864, DOI 10.1200/JCO.2011.40.2180
   Enblom A, 2012, ANN ONCOL, V23, P1353, DOI 10.1093/annonc/mdr402
   Fedirko V, 2012, CANCER EPIDEM BIOMAR, V21, P582, DOI 10.1158/1055-9965.EPI-11-1065
   Fife J, 2011, COLORECTAL DIS, V13, P132, DOI 10.1111/j.1463-1318.2009.02089.x
   Gabius HJ, 2001, CANCER INVEST, V19, P114, DOI 10.1081/CNV-100000146
   Gaglio D, 2011, MOL SYST BIOL, V7, DOI 10.1038/msb.2011.56
   Gibson RJ, 2013, SUPPORT CARE CANCER, V21, P313, DOI 10.1007/s00520-012-1644-z
   Guo L, 2012, MED ONCOL, V29, P1656, DOI 10.1007/s12032-011-0068-9
   Hankey GJ, 2012, STROKE, V43, P1572, DOI 10.1161/STROKEAHA.111.641613
   Harris HR, 2012, BREAST CANCER RES TR, V134, P1269, DOI 10.1007/s10549-012-2139-9
   Horneber MA, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003297.pub2
   Hurst R, 2012, AM J CLIN NUTR, V96, P111, DOI 10.3945/ajcn.111.033373
   Hurst R, 2010, AM J CLIN NUTR, V91, P923, DOI 10.3945/ajcn.2009.28169
   Johansson M, 2008, CANCER EPIDEM BIOMAR, V17, P279, DOI 10.1158/1055-9965.EPI-07-0657
   Kassab S, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004845.pub2
   Kennedy DA, 2011, CANCER EPIDEMIOL, V35, P2, DOI 10.1016/j.canep.2010.11.004
   Kim KC, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-172
   Klein EA, 2011, JAMA-J AM MED ASSOC, V306, P1549, DOI 10.1001/jama.2011.1437
   Kucuktulu E, 2013, SUPPORT CARE CANCER, V21, P1071, DOI 10.1007/s00520-012-1627-0
   Martinez-Outschoorn UE, 2011, CELL CYCLE, V10, P4208, DOI 10.4161/cc.10.24.18487
   McCulloch M, 2006, J CLIN ONCOL, V24, P419, DOI 10.1200/JCO.2005.03.6392
   Melzer J, 2009, FORSCH KOMPLEMENTMED, V16, P217, DOI 10.1159/000226249
   Mikirova N, 2012, J TRANSL MED, V10, DOI 10.1186/1479-5876-10-189
   Modan-Moses D, 2012, PEDIATR RES, V72, P620, DOI 10.1038/pr.2012.131
   MOERTEL CG, 1985, NEW ENGL J MED, V312, P137, DOI 10.1056/NEJM198501173120301
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Monti DA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029794
   Murphy RA, 2011, CANCER-AM CANCER SOC, V117, P1775, DOI 10.1002/cncr.25709
   O'Sullivan EM, 2010, ACUPUNCT MED, V28, P191, DOI 10.1136/aim.2010.002733
   Oberbaum M, 2001, CANCER, V92, P684, DOI 10.1002/1097-0142(20010801)92:3<684::AID-CNCR1371>3.0.CO;2-#
   Ostermann T, 2012, EXPLORE-NY, V8, P277, DOI 10.1016/j.explore.2012.06.005
   Paller CJ, 2013, PROSTATE CANCER P D, V16, P50, DOI 10.1038/pcan.2012.20
   Pantuck AJ, 2006, CLIN CANCER RES, V12, P4018, DOI 10.1158/1078-0432.CCR-05-2290
   Pérol D, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-603
   Pilz S, 2013, ANTI-CANCER AGENT ME, V13, P107, DOI 10.2174/187152013804487407
   Rosen GP, 2013, PEDIATR BLOOD CANCER, V60, P949, DOI 10.1002/pbc.24349
   Simcock R, 2013, ANN ONCOL, V24, P776, DOI 10.1093/annonc/mds515
   Song YQ, 2012, J NATL CANCER I, V104, P1562, DOI 10.1093/jnci/djs370
   Steinbrecher A, 2012, CANCER EPIDEM BIOMAR, V19, P2958
   Sultan J, 2012, BRIT J SURG, V99, P346, DOI 10.1002/bjs.7799
   Thies A, 2005, TOXICOLOGY, V207, P105, DOI 10.1016/j.tox.2004.09.009
   van der Rhee H, 2013, EUR J CANCER, V49, P1422, DOI 10.1016/j.ejca.2012.11.001
   Wang WS, 2007, ONCOLOGIST, V12, P312, DOI 10.1634/theoncologist.12-3-312
   Wong RKW, 2003, INT J RADIAT ONCOL, V57, P472, DOI 10.1016/S0360-3016(03)00572-8
   Worthington HV, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD000978.pub5
   Yeh CH, 2012, J ALTERN COMPLEM MED, V18, P334, DOI 10.1089/acm.2011.0102
   Zeller T, 2013, J CANCER RES CLIN, V139, P357, DOI 10.1007/s00432-012-1336-6
NR 59
TC 1
Z9 2
U1 0
U2 22
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0947-8965
EI 1433-0415
J9 ONKOLOGE
JI Onkologe
PD NOV
PY 2013
VL 19
IS 11
BP 970
EP +
DI 10.1007/s00761-013-2541-x
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 247EY
UT WOS:000326599800009
DA 2026-01-16
ER

PT J
AU Sedhom, R
   Gupta, A
   Wang, L
   Paller, C
   Bao, T
AF Sedhom, Ramy
   Gupta, Arjun
   Wang, Lin
   Paller, Channing
   Bao, Ting
TI Payer Coverage of Integrative Medicine Interventions for Symptom Control
   in Patients With Cancer
SO JCO ONCOLOGY PRACTICE
LA English
DT Editorial Material
ID RANDOMIZED CONTROLLED-TRIAL; BREAST-CANCER; ALTERNATIVE MEDICINE;
   ACUPUNCTURE; PAIN; ONCOLOGY; COMPLEMENTARY; MANAGEMENT; SURVIVORS;
   EXERCISE
C1 [Sedhom, Ramy] Penn Med, Div Hematol & Oncol, Philadelphia, PA USA.
   [Gupta, Arjun; Paller, Channing] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA.
   [Wang, Lin] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Wang, Lin] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Drug Safety & Effectiveness, Baltimore, MD USA.
   [Bao, Ting] Mem Sloan Kettering Canc, Dept Med, Integrat Med & Breast Med Serv, New York, NY USA.
C3 University of Pennsylvania; Pennsylvania Medicine; Johns Hopkins
   University; Johns Hopkins Medicine; Johns Hopkins University; Johns
   Hopkins Bloomberg School of Public Health; Johns Hopkins University;
   Johns Hopkins Bloomberg School of Public Health; Memorial Sloan
   Kettering Cancer Center
RP Sedhom, R (corresponding author), Penn Med Princeton Hlth, 5 Plainsboro Rd,Suite 500, Plainsboro, NJ 08536 USA.
EM ramy.sedhom@pennmedicine.upenn.edu
OI Paller, Channing/0000-0003-3658-1858; Gupta, Arjun/0000-0003-0875-4731;
   Wang, Lin/0000-0003-2046-4366; Bao, Ting/0000-0003-4437-2597
FU individual Conquer Cancer ASCO Young Investigator Awards
FX R.S. and A.G. are supported by individual Conquer Cancer ASCO Young
   Investigator Awards.
CR Bao T, 2018, ACUPUNCT MED, V36, P80, DOI 10.1136/acupmed-2017-011435
   Brauer JA, 2010, J ALTERN COMPLEM MED, V16, P183, DOI 10.1089/acm.2009.0354
   Courneya KS, 2007, CANCER EPIDEM BIOMAR, V16, P2572, DOI 10.1158/1055-9965.EPI-07-0413
   Courneya KS, 2009, J CLIN ONCOL, V27, P4605, DOI 10.1200/JCO.2008.20.0634
   Dy SM., 2020, INTERVENTIONS BREATH
   Fan AY, 2018, J INTEGR MED-JIM, V16, P1, DOI 10.1016/j.joim.2017.12.003
   Fritts Matthew, 2009, Explore (NY), V5, P228, DOI 10.1016/j.explore.2009.05.013
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Gewandter JS, 2020, SUPPORT CARE CANCER, V28, P2553, DOI 10.1007/s00520-019-05063-x
   Greenlee H, 2019, J ONCOL PRACT, V15, P17, DOI 10.1200/JOP.18.00755
   Gupta A, 2021, JAMA ONCOL, V7, P290, DOI 10.1001/jamaoncol.2020.5184
   Gupta A, 2020, JCO ONCOL PRACT, V16, P733, DOI 10.1200/OP.20.00113
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hershman DL., 2021, J CLIN ONCOL, V39
   Heyward J, 2018, JAMA NETW OPEN, V1, DOI 10.1001/jamanetworkopen.2018.3044
   Hu CQ, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1720239
   Kuo YF, 2016, AM J MED, V129, DOI 10.1016/j.amjmed.2015.10.002
   Latte-Naor S, 2019, J ONCOL PRACT, V15, P7, DOI 10.1200/JOP.18.00554
   Liou KT, 2019, PAIN MED, V20, P2060, DOI 10.1093/pm/pnz087
   Mao JJ, 2018, J CLIN ONCOL, V36, DOI 10.1200/JCO.2018.36.15_suppl.10001
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   McGivney WT, 2010, J NATL COMPR CANC NE, V8, P625, DOI 10.6004/jnccn.2010.0048
   Meng ZQ, 2012, EUR J CANCER, V48, P1692, DOI 10.1016/j.ejca.2011.12.030
   Naeim A, 2008, J CLIN ONCOL, V26, P3903, DOI 10.1200/JCO.2007.15.9533
   Nahin Richard L, 2016, NCHS Data Brief, P1
   Paice JA, 2016, J CLIN ONCOL, V34, P3325, DOI 10.1200/JCO.2016.68.5206
   Polite BN, 2019, JAMA-J AM MED ASSOC, V321, P1663, DOI 10.1001/jama.2019.4266
   Saper Robert, 2016, Glob Adv Health Med, V5, P5, DOI [10.7453/gahmj.2015.133, 10.7453/gahmj.2015.133]
   Sedhom R, 2020, JCO ONCOL PRACT, V16, P537, DOI 10.1200/OP.20.00137
   Swarm RA, 2019, J NATL COMPR CANC NE, V17, P977, DOI 10.6004/jnccn.2019.0038
   Witt CM, 2009, AM J EPIDEMIOL, V169, P562, DOI 10.1093/aje/kwn370
   Yun Hyeongjun, 2017, Journal of the National Cancer Institute Monographs, P29, DOI [10.1093/jncimonographs/lgx004, 10.1093/jncimonographs/lgx004]
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 33
TC 10
Z9 11
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2688-1527
EI 2688-1535
J9 JCO ONCOL PRACT
JI JCO Oncol. Pract.
PD OCT
PY 2021
VL 17
IS 10
BP 587
EP +
DI 10.1200/OP.21.00361
PG 5
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA WI1AW
UT WOS:000708099700001
PM 34310190
OA Bronze
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Farrar, JT
AF Mao, Jun J.
   Farrar, John T.
TI Acupuncture for Aromatase Inhibitor-Related Joint Pain Among Breast
   Cancer Patients
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Letter
C1 [Mao, Jun J.] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
   [Farrar, John T.] Univ Penn, Philadelphia, PA 19104 USA.
C3 Memorial Sloan Kettering Cancer Center; University of Pennsylvania
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, 1429 First Ave, New York, NY 10021 USA.
EM maoj@mskcc.org
RI Farrar, John/AAP-4788-2021
FU Office of Diversity, Inclusion, Community Engagement, and Equity at the
   Yale School of Medicine
FX This work was supported by funds from the Office of Diversity,
   Inclusion, Community Engagement, and Equity at the Yale School of
   Medicine.
CR Farrar JT, 2000, CLIN J PAIN, V16, pS106, DOI 10.1097/00002508-200006001-00018
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Moore RA, 2010, ANN RHEUM DIS, V69, P374, DOI 10.1136/ard.2009.107805
   Reinhold T, 2008, EUR J HEALTH ECON, V9, P209, DOI 10.1007/s10198-007-0062-5
NR 4
TC 1
Z9 2
U1 0
U2 23
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD DEC 4
PY 2018
VL 320
IS 21
BP 2269
EP 2270
DI 10.1001/jama.2018.16736
PG 2
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HD4MB
UT WOS:000452500600021
PM 30512092
DA 2026-01-16
ER

PT J
AU Oh, B
   Eade, T
   Kneebone, A
   Pavlakis, N
   Clarke, S
   Eslick, G
   River, J
   Back, M
AF Oh, Byeongsang
   Eade, Thomas
   Kneebone, Andrew
   Pavlakis, Nick
   Clarke, Stephen
   Eslick, Guy
   River, Jo
   Back, Michael
TI Factors affecting whether or not cancer patients consider using
   acupuncture
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; ALTERNATIVE MEDICINE USE; STAGE
   BREAST-CANCER; COMPLEMENTARY THERAPIES; JOINT SYMPTOMS; HOT FLASHES;
   MANAGEMENT; WOMEN; PHYSICIANS; CHEMOTHERAPY
AB Objective To explore the factors associated with utilisation of an acupuncture service in a tertiary oncology setting in an Australian public hospital.
   Method Cancer patients attending oncology clinics at a university teaching hospital were invited to participate in the evaluation of acupuncture services from June 2014 to May 2015. Patients had a prior diagnosis of cancer (albeit at different stages) and were planning to receive, or were already receiving, systemic and/or radiation cancer treatment.
   Results The majority (81%) of participants indicated that they would consider the use of acupuncture during their cancer treatment. The most common reasons given for not considering acupuncture included adequate control of symptoms already with medical treatment, inconvenient clinic timing, and needle phobia. The main reasons given for considering acupuncture use included its perceived capability of reducing fatigue, boosting energy levels, improving immune function, and reducing pain and anxiety. Patients considering acupuncture use also demonstrated significantly higher levels of stress (p<0.001), anxiety and depression (p<0.001), fatigue (p<0.001), and lower global quality of life (p<0.01) compared to those who were not considering acupuncture.
   Conclusions The findings show that demand for acupuncture by cancer patients is high. A substantial proportion of cancer patients intend to use acupuncture to manage cancer and/or cancer treatment-related symptoms. Discussion with patients about acupuncture and other complementary therapies during the consultation may improve cancer care.
C1 [Oh, Byeongsang; Eade, Thomas; Kneebone, Andrew; Pavlakis, Nick; Clarke, Stephen; Back, Michael] Royal North Shore Hosp, Northern Sydney Canc Ctr, Sydney, NSW, Australia.
   [Oh, Byeongsang; Eade, Thomas; Kneebone, Andrew; Pavlakis, Nick; Clarke, Stephen; Eslick, Guy; Back, Michael] Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia.
   [Oh, Byeongsang] Harvard Med Sch, Boston, MA USA.
   [River, Jo] Univ Sydney, Sydney Nursing Sch, Camperdown, NSW, Australia.
C3 University of Sydney; Royal North Shore Hospital; University of Sydney;
   Harvard University; Harvard Medical School; University of Sydney
RP Oh, B (corresponding author), Univ Sydney, Sydney Med Sch, Northern Sydney Canc Ctr, Royal North Shore Hosp, St Leonards, NSW 2065, Australia.
EM byeong.oh@sydney.edu.au
RI Oh, Byeongsang/ABH-1460-2020; Eslick, Guy/HMT-5739-2023; Clarke,
   Stephen/HNR-3821-2023; River, Jo/ABE-6568-2020
OI Eade, Thomas/0000-0003-4324-1886; Eslick, Guy/0000-0002-0098-1705;
   Clarke, Stephen/0000-0001-5817-1222; Kneebone, Anew/0000-0002-7629-504X;
   Back, Michael/0000-0003-2363-8333; River, Jo/0000-0002-5270-4013
FU Northern Sydney Local Health District NSW; Dry July
FX This study was supported by the Dry July and Northern Sydney Local
   Health District NSW.
CR Adams J, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-2
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   [Anonymous], 2006, CANC AUSTR OV
   [Anonymous], 2009, CANC FACTS FIG 2009
   Ashikaga T, 2002, SUPPORT CARE CANCER, V10, P542, DOI 10.1007/s00520-002-0356-1
   Begbie SD, 1996, MED J AUSTRALIA, V165, P545, DOI 10.5694/j.1326-5377.1996.tb138639.x
   Beith JM, 2011, MED ACUPUNCT, V23, P151, DOI 10.1089/acu.2011.0798
   Boon Heather S, 2007, BMC Womens Health, V7, P4, DOI 10.1186/1472-6874-7-4
   Commonwealth of Australia, 2009, HLTH FUT ALL AUSTR F
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   de Valois BA, 2010, J ALTERN COMPLEM MED, V16, P1047, DOI 10.1089/acm.2009.0472
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Deng GE, 2013, CHEST, V143, pE420, DOI 10.1378/chest.12-2364
   Greenlee Heather, 2014, Journal of the National Cancer Institute Monographs, P346, DOI 10.1093/jncimonographs/lgu041
   Halsey EJ, 2015, ACUPUNCT MED, V33, P188, DOI 10.1136/acupmed-2014-010735
   Highfield ES, 2003, COMPLEMENT THER MED, V11, P177, DOI 10.1016/S0965-2299(03)00069-4
   Johnstone P A., Palliat Med
   Kremser T, 2008, BREAST, V17, P387, DOI 10.1016/j.breast.2007.12.006
   Lafferty WE, CANCER
   Leng G, 1999, PALLIATIVE MED, V13, P163, DOI 10.1191/026921699676243035
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Mao JJ, 2012, J AM BOARD FAM MED, V25, P323, DOI 10.3122/jabfm.2012.03.110165
   Mehling WE, 2007, J PAIN SYMPTOM MANAG, V33, P258, DOI 10.1016/j.jpainsymman.2006.09.016
   Miller M, 1998, SUPPORT CARE CANCER, V6, P337, DOI 10.1007/s005200050175
   Molassiotis A, 2005, ANN ONCOL, V16, P655, DOI 10.1093/annonc/mdi110
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P228, DOI 10.1016/j.ctim.2006.09.009
   Morris KT, 2000, AM J SURG, V179, P407, DOI 10.1016/S0002-9610(00)00358-5
   National Institutes of Health, 2007, CAM BAS SEC CAM BAS
   Oh Byeongsang, 2010, J Soc Integr Oncol, V8, P56
   Paltiel O, 2001, J CLIN ONCOL, V19, P2439, DOI 10.1200/JCO.2001.19.9.2439
   Richardson MA, 2000, J CLIN ONCOL, V18, P2505, DOI 10.1200/JCO.2000.18.13.2505
   Saxe GA, 2008, INTEGR CANCER THER, V7, P122, DOI 10.1177/1534735408323081
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   Standish LJ, 2008, AM J HOSP PALLIAT ME, V25, P298, DOI 10.1177/1049909108315916
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   Xue CCL, J ALTERN COMPLEMENT
   Zhang Y, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/710750
NR 37
TC 13
Z9 16
U1 0
U2 9
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD APR
PY 2017
VL 35
IS 2
BP 107
EP 113
DI 10.1136/acupmed-2016-011115
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EV7OU
UT WOS:000401967300004
PM 27658799
DA 2026-01-16
ER

PT J
AU Efverman, A
AF Efverman, Anna
TI Understanding Placebo and Nocebo Responses Based on a Randomized
   Sham-Controlled Study on Acupuncture in Integrative Cancer Care
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; cancer; contextual effects; traditional; complementary; and
   integrative medicine; expectations; nursing; oncology; psycho-oncology
ID CHRONIC PAIN; HOT FLASHES; TRIALS; METAANALYSIS; EXPERIENCES; QUESTION;
   PATIENT; CONTEXT
AB Objective: Since placebo and nocebo-responses during acupuncture therapy are rarely studied in clinical contexts, the objective was to investigate placebo and nocebo-responses in a clinical context through comparing positive and negative side-effects between genuine and sham acupuncture, and to identify factors modifying placebo and nocebo-responses. Methods: Patients reported positive side-effects (non-intended positive effects) or negative side-effects (non-intended negative effects) of genuine (penetrating; n = 109) or sham (telescopic non-penetrating; n = 106) acupuncture during 5 weeks of chemoradiation for cancer. Results: The genuine and the sham acupuncture group reported rather similar frequencies of positive (P-values .223-.800) or negative (P-values .072-1.0) side-effects: relaxation 59%/57% of the patients, improved mood 46%/38%, improved sleep 38%/38%, pain-reduction 36%/28%, tiredness 42%/42%, feeling cold 37%/31%, sweating 23%/21%, and dizziness 20%/12%. Positive side-effects occurred in 79% of patients who highly believed acupuncture to be effective, compared to in 0% of patients who did not believe. Other factors associated with placebo-response were female sex (P = .042), anxious mood (P = .007), depressed mood (P = .018), and blinding-success (P = .033). Factors associated with nocebo response were female sex (P = .049), younger age (P = .010), and needle-induced pain (P = .014). Sham-treated patients experiencing positive side-effects experienced better quality of life at the end of the treatment period (mean, m 64 on a scale 0-100 millimetres, Standard Deviation, SD, +/- 26.1 mm) than those who did not (m 48 +/- 25.5 mm), P = .048 (adjusted for other characteristics). Conclusions: Clinically significant levels of placebo and nocebo effects commonly occurred during acupuncture therapy in integrative cancer care and this paper identified factors modifying these responses. This implicates that acupuncture-delivering therapists striving to maximize placebo-responses and minimize nocebo-responses may considering strengthen the patient's treatment expectations, and offer a pleasant, pain-free, acupuncture treatment.
C1 [Efverman, Anna] Univ Gavle, Gavle, Sweden.
C3 University of Gavle
RP Efverman, A (corresponding author), Univ Gavle, Fac Hlth & Occupat Studies, Dept Caring Sci, S-80176 Gavle, Sweden.
EM anna.efverman@hig.se
FU Swedish Cancer Society; Vardal Institute; Region of Ostergotland;
   University of Linkoping; Cancer Rehabilitation Foundation; University of
   Gavle
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   original randomized controlled trial was supported by the Swedish Cancer
   Society, the Vardal Institute, the Region of Ostergotland, the
   University of Linkoping, and the Cancer Rehabilitation Foundation. The
   University of Gavle funded writing of this paper
CR Bajcar EA, 2024, J PAIN, V25, DOI 10.1016/j.jpain.2024.104585
   Barth J, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.21418
   Barth J, 2016, J PAIN, V17, P685, DOI 10.1016/j.jpain.2016.01.477
   Bizzi F, 2019, EUR ANN ALLERGY CLIN, V51, P258, DOI 10.23822/EurAnnACI.1764-1489.116
   Blasini M, 2018, INT REV NEUROBIOL, V139, P211, DOI 10.1016/bs.irn.2018.07.033
   Bowling A, 2005, J EPIDEMIOL COMMUN H, V59, P342, DOI 10.1136/jech.2004.021204
   Caliskan EB, 2024, PAIN REP, V9, DOI 10.1097/PR9.0000000000001142
   Chae Y, 2017, ACUPUNCT MED, V35, P148, DOI 10.1136/acupmed-2016-011178
   Colagiuri B, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/857804
   Colloca L, 2024, ANNU REV PHARMACOL, V64, P171, DOI 10.1146/annurev-pharmtox-022723-112425
   Colloca L, 2020, PSYCHOTHER PSYCHOSOM, V89, P371, DOI 10.1159/000507400
   De Melo MN, 2022, CURR ONCOL REP, V24, P1363, DOI 10.1007/s11912-022-01296-y
   Dodd S, 2019, BIPOLAR DISORD, V21, P142, DOI 10.1111/bdi.12662
   Ee CC, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186966
   Efverman A, 2024, INTEGR CANCER THER, V23, DOI 10.1177/15347354241273944
   Efverman A, 2020, COMPLEMENT THER MED, V52, DOI 10.1016/j.ctim.2020.102404
   Ellerbrock I, 2015, PAIN, V156, P2222, DOI 10.1097/j.pain.0000000000000297
   Enblom A, 2012, ANN ONCOL, V23, P1353, DOI 10.1093/annonc/mdr402
   Enblom A, 2017, ACUPUNCT MED, V35, P421, DOI 10.1136/acupmed-2016-011270
   Enblom A, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1155/2011/185034
   Enblom A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014766
   Evers AWM, 2020, PSYCHOTHER PSYCHOSOM, V90, P49, DOI 10.1159/000510738
   Ezzatvar Y, 2024, J ORTHOP SPORT PHYS, V54, P391, DOI 10.2519/jospt.2024.12126
   Furukawa TA, 2016, LANCET PSYCHIAT, V3, P1059, DOI 10.1016/S2215-0366(16)30307-8
   Geers AL, 2010, J PAIN, V11, P1165, DOI 10.1016/j.jpain.2010.02.014
   Guo J, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420959442
   Haas JW, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2021.43955
   Hansen E, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00077
   Hayden JA, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011284.pub2
   Howick J, 2018, J ROY SOC MED, V111, P240, DOI 10.1177/0141076818769477
   Huemer M, 2024, J INTEGR MED-JIM, V22, P64, DOI 10.1016/j.joim.2023.12.002
   Isawa M, 2020, PHARMAZIE, V75, P548, DOI 10.1691/ph.2020.0642
   Kang H, 2023, PAIN, V164, P494, DOI 10.1097/j.pain.0000000000002753
   Kaptchuk TJ, 2008, BMJ-BRIT MED J, V336, P999, DOI 10.1136/bmj.39524.439618.25
   Kelley JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094207
   Kelley JM, 2009, PSYCHOSOM MED, V71, P789, DOI 10.1097/PSY.0b013e3181acee12
   Kim TH, 2020, ACUPUNCT MED, V38, P37, DOI 10.1136/acupmed-2018-011671
   Kong J, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0081049, 10.1371/journal.pone.0067485]
   Koog YH, 2014, J CLIN EPIDEMIOL, V67, P858, DOI 10.1016/j.jclinepi.2014.02.021
   Lagerstedt K, 2023, INTEGR CANCER THER, V22, DOI 10.1177/15347354231178877
   LASAGNA L, 1954, AM J MED, V16, P770, DOI 10.1016/0002-9343(54)90441-6
   Lee SM, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419890029
   Li XT, 2024, INTEGR MED RES, V13, DOI 10.1016/j.imr.2024.101040
   Lou JS, 2020, INT REV NEUROBIOL, V153, P187, DOI 10.1016/bs.irn.2020.03.031
   Mao JJ, 2022, CA-CANCER J CLIN, V72, P144, DOI 10.3322/caac.21706
   Mao JJ, 2015, J CLIN ONCOL, V33, P3615, DOI 10.1200/JCO.2015.60.9412
   Meissner K, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00410
   Odsberg A, 2001, COMPLEMENT THER MED, V9, P17, DOI 10.1054/ctim.2000.0418
   Olson EM, 2021, PAIN, V162, P531, DOI 10.1097/j.pain.0000000000002038
   Palermo S, 2015, HUM BRAIN MAPP, V36, P1648, DOI 10.1002/hbm.22727
   Park JJ, 2009, ACUPUNCT MED, V27, P93, DOI 10.1136/aim.2009.001495
   Porporatti AL, 2019, J ORAL REHABIL, V46, P862, DOI 10.1111/joor.12827
   Riess H, 2010, JAMA-J AM MED ASSOC, V304, P1604, DOI 10.1001/jama.2010.1455
   Rooney T, 2023, HEALTH PSYCHOL REV, V17, P550, DOI 10.1080/17437199.2022.2125894
   Roscoe JA, 2010, J PAIN SYMPTOM MANAG, V40, P379, DOI 10.1016/j.jpainsymman.2009.12.024
   Scheffold BE, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/641742
   Skoogh J, 2010, ANN ONCOL, V21, P1905, DOI 10.1093/annonc/mdq058
   Vase L, 2020, SCAND J PAIN, V20, P451, DOI 10.1515/sjpain-2019-0183
   Wager TD, 2015, NAT REV NEUROSCI, V16, P403, DOI 10.1038/nrn3976
   Wang SM, 2024, MOVEMENT DISORD, V39, P585, DOI 10.1002/mds.29714
   Wang Y, 2022, PAIN, V163, P1078, DOI 10.1097/j.pain.0000000000002478
   Wasan AD, 2006, PAIN MED, V7, P217, DOI 10.1111/j.1526-4637.2006.00154.x
   WATSON M, 1988, PSYCHOL MED, V18, P203, DOI 10.1017/S0033291700002026
   Widgren Y, 2023, INTEGR CANCER THER, V22, DOI 10.1177/15347354231217296
   Wilhelm M, 2024, FRONT PSYCHOL, V15, DOI 10.3389/fpsyg.2024.1398865
   Williamson A, 2005, J CLIN NURS, V14, P798, DOI 10.1111/j.1365-2702.2005.01121.x
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
   Wu JY, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/432467
   Zhang Y, 2022, J CLIN PHARMACOL, V62, P1257, DOI 10.1002/jcph.2072
NR 69
TC 4
Z9 4
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2024
VL 23
AR 15347354241300068
DI 10.1177/15347354241300068
PG 15
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA M3B0S
UT WOS:001356316400001
PM 39548800
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Park, S
   Gu, JH
   Jang, HK
   Oh, MS
   Lee, EJ
   Jung, IC
AF Park, Sohyeon
   Gu, Ji-Hyang
   Jang, Hye-Kyoung
   Oh, Min-Seok
   Lee, Eun-Jung
   Jung, In Chul
TI Electroacupuncture for post-thoracotomy pain Protocol for a systematic
   review and meta-analysis
SO MEDICINE
LA English
DT Review
DE electroacupuncture; postoperative pain management thoracotomy
ID MANAGEMENT
AB Background: Thoracotomy is a common surgical procedure used in cases such as trauma and cancer resection. It is an invasive procedure in which incisions are made in the chest wall to gain access to the chest. Therefore. it often produces intense postoperative pain. Electroacupuncture has been known for its analgesic effects in various conditions. including cases of postoperative pain. This protocol design is for a systematic review and meta-analysis to gather evidence and investigate the analgesic effects of electroacupuncture in pain after thoracotomy.
   Methods: The studies for the systematic review will be searched with keywords on the following 10 databases: PubMed. Cochrane Library (CENTRAL), EMBASE, MEDLINE, Google Scholar, CNKI, KoreaMed, KMBASE, KISS, and OASIS. The search will be done without language restrictions. Only the randomized controlled trials that meet the eligibility criteria will be finally included in the study. The quality of the study will be assessed using the Cochrane Collaborations" risk-of-bias tool, and Cochrane's software RevMan 5.3 will be used for meta-analysis.
   Results: The designed study will provide a systematic review and meta-analysis of the searched and randomized controlled trials that meet the eligibility criteria. Meta-analysis will be performed with pain scores as the main outcome measure, and they may also be performed with additional outcomes. The qualitative and quantitative data synthesis is expected to provide high quality evidence to judge the pain management effect of electroacupuncture for patients who underwent thoracotomy.
   Conclusion: The conclusion of this systematic review and meta-analysis will provide evidence to judge whether electroacupuncture is an effective analgesic treatment option for patients suffering with post-thoracotomy pain.
C1 [Park, Sohyeon] Daejeon Univ, Coll Korean Med, Daejeon, South Korea.
   [Gu, Ji-Hyang; Oh, Min-Seok; Lee, Eun-Jung] Daejeon Univ, Coll Korean Med, Dept Korean Rehabil Med, 62 Daehak Ro, Daejeon 34520, South Korea.
   [Jang, Hye-Kyoung] Daejeon Univ, Dunsan Korean Med Hosp, Clin Trial Ctr, Daejeon, South Korea.
   [Jung, In Chul] Daejeon Univ, Coll Korean Med, Dept Oriental Neuropsychiat, 62 Daehak Ro, Daejeon 34520, South Korea.
C3 Daejeon University; Daejeon University; Daejeon University; Daejeon
   University
RP Lee, EJ (corresponding author), Daejeon Univ, Coll Korean Med, Dept Korean Rehabil Med, 62 Daehak Ro, Daejeon 34520, South Korea.; Jung, IC (corresponding author), Daejeon Univ, Coll Korean Med, Dept Oriental Neuropsychiat, 62 Daehak Ro, Daejeon 34520, South Korea.
EM jungkahn@dju.kr; npjeong@dju.kr
OI Lee, Eun-Jung/0000-0001-9468-9694
FU Ministry of Health and Welfare, Republic of Korea [HI15C0006]
FX This study was supported by a grant from the Ministry of Health and
   Welfare, Republic of Korea, in 2019 (HI15C0006).
CR CHENG RSS, 1979, LIFE SCI, V25, P1957, DOI 10.1016/0024-3205(79)90598-8
   COOK TD, 1980, J PERS, V48, P449, DOI 10.1111/j.1467-6494.1980.tb02379.x
   DUTHIE DJR, 1987, BRIT J ANAESTH, V59, P61, DOI 10.1093/bja/59.1.61
   Gerner Peter, 2008, Anesthesiol Clin, V26, P355, DOI 10.1016/j.anclin.2008.01.007
   Glare P, 2019, LANCET, V393, P1537, DOI 10.1016/S0140-6736(19)30352-6
   Maguire MF, 2006, EUR J CARDIO-THORAC, V29, P800, DOI 10.1016/j.ejcts.2006.02.002
   Meade MO, 1997, ANN INTERN MED, V127, P531, DOI 10.7326/0003-4819-127-7-199710010-00005
   NIDA, 2019, OV DEATH RAT
   Pussegoda K, 2017, SYST REV-LONDON, V6, DOI 10.1186/s13643-017-0507-6
   Smith V, 2011, BMC MED RES METHODOL, V11, DOI 10.1186/1471-2288-11-15
   Somogyi AA, 2007, CLIN PHARMACOL THER, V81, P429, DOI 10.1038/sj.clpt.6100095
   WILSON GT, 1983, J CONSULT CLIN PSYCH, V51, P54, DOI 10.1037/0022-006X.51.1.54
NR 12
TC 3
Z9 3
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB
PY 2020
VL 99
IS 9
AR e19312
DI 10.1097/MD.0000000000019312
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LD2LY
UT WOS:000525865600058
PM 32118757
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yang, LH
   Li, SY
   Yang, Y
   Yang, SN
   Guo, HL
   Hu, MM
   Duan, PB
   Xia, C
AF Yang, Li-Hua
   Li, Si-Yu
   Yang, Ya
   Yang, Sheng-Nan
   Guo, Hai-Li
   Hu, Ming-Ming
   Duan, Pei-Bei
   Xia, Chao
TI Effectiveness of Acupressure in Managing the Pain-Fatigue-Sleep
   Disturbance-Depression Symptom Cluster in Patients with Cancer: A
   Systematic Review and Meta-Analysis of Randomized Controlled Trials
SO JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review
DE symptom cluster; acupressure; systematic review; meta-analysis
ID AURICULAR POINT ACUPRESSURE; INTERVENTIONS; MECHANISMS; CARE
AB Objective: To assess the effectiveness of acupressure in addressing the symptom cluster of pain, fatigue, sleep disturbances, and depression (P-F-S-D) in patients with cancer through a systematic review.Methods: A comprehensive search was conducted across three English-language medical databases (PubMed, Embase, and the Cochrane Library) and two Chinese databases (China National Knowledge Infrastructure and Wanfang). Only randomized controlled trials (RCTs) examining the impact of acupressure on the P-F-S-D symptom cluster were included. Two reviewers independently screened studies, evaluated the risk of bias, and extracted relevant data in parallel. The risk of bias in eligible RCTs was appraised using the revised Cochrane Risk of Bias tool (RoB 2.0). Meta-analysis was performed using Stata software.Results: A total of 20 studies (reported in 21 articles) met the inclusion criteria and were classified as either having a low risk of bias or some concerns regarding bias. Meta-analysis revealed that acupressure achieved large-effect reductions in the P-F-S-D symptom cluster compared to both sham acupoint (endpoint standardized mean difference [SMD] = -0.84 [-1.05, -0.63], 4-week follow-up SMD = -0.87 [-1.35, -0.39]) and usual care groups (endpoint SMD = -0.68 [-0.83, -0.53], 4-week follow-up SMD = -0.60 [-0.87, -0.33]) (all p = 0.000). Initial high heterogeneity (I2 = 65.6%-67.1%) resolved after sensitivity analysis (I2 = 19.7%-35.2%), confirming result robustness. Subgroup analysis further revealed that acupressure significantly benefited various symptom combinations, including P-F-S-D, P-F-S, F-S-D, F-S, P-S, and P-F. No serious adverse events were reported.Conclusions: The findings of this study suggest that acupressure should be considered for patients with cancer experiencing the P-F-S-D symptom cluster. However, given the considerable heterogeneity, potential bias, and lack of systematic adverse event reporting in the included studies, further large-scale, multicenter, high-quality RCTs are necessary to better evaluate the effectiveness and safety of acupressure for multisymptom relief.
C1 [Yang, Li-Hua; Yang, Ya; Yang, Sheng-Nan; Guo, Hai-Li; Hu, Ming-Ming] Jiangsu Hlth Vocat Coll, Sch Hlth Wellness & Educ, Nanjing, Peoples R China.
   [Li, Si-Yu] Nanjing Univ Chinese Med, Sch Nursing, Nanjing, Peoples R China.
   [Duan, Pei-Bei; Xia, Chao] Jiangsu Prov Hosp Chinese Med, Dept Oncol, 155 Hanzhong Rd, Nanjing 210029, Jiangsu Provinc, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Xia, C (corresponding author), Jiangsu Prov Hosp Chinese Med, Dept Oncol, 155 Hanzhong Rd, Nanjing 210029, Jiangsu Provinc, Peoples R China.
EM lajiao797@sina.com
RI Hu, Ming-Ming/AAX-4704-2020
CR Arai YCP, 2008, ANESTH ANALG, V107, P661, DOI 10.1213/ane.0b013e31817b8495
   Turan GB, 2023, CANCER NURS, V46, P457, DOI 10.1097/NCC.0000000000001193
   Bower JE, 2014, NAT REV CLIN ONCOL, V11, P597, DOI 10.1038/nrclinonc.2014.127
   Bray F, 2024, CA-CANCER J CLIN, V74, P229, DOI 10.3322/caac.21834
   Cheung DST, 2022, EUR J CANCER CARE, V31, DOI 10.1111/ecc.13314
   Cumpston M, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000142
   Dogan MD, 2024, INDIAN J PALLIAT CAR, V30, P10, DOI 10.25259/IJPC_95_2023
   Doong SH, 2015, BIOL RES NURS, V17, P237, DOI 10.1177/1099800414550394
   [费超男 Fei Chaonan], 2023, [护理学杂志, Journal of Nursing Science], V38, P65
   Goetze H, 2020, SUPPORT CARE CANCER, V28, P211, DOI 10.1007/s00520-019-04805-1
   He C, 2022, Chin Gen Pract, V19, P2414, DOI [10.11124/JBISRIR-2016-2476, DOI 10.12114/J.ISSN.1007-9572.2022.0086]
   He CC., 2022, J GANNAN MED U, V42, P1193, DOI [10.3969/j.issn.1001-5779.2022.11.012, DOI 10.3969/J.ISSN.1001-5779.2022.11.012]
   Huong HTX, 2022, SLEEP BREATH, V26, P445, DOI 10.1007/s11325-021-02370-8
   Hoang HTX, 2020, SLEEP BREATH, V24, P241, DOI 10.1007/s11325-019-01839-x
   Ji YB, 2017, J PAIN SYMPTOM MANAG, V54, P843, DOI 10.1016/j.jpainsymman.2017.05.003
   [金艾香 Jin Aixiang], 2021, [中国护理管理, Chinese Nursing Management], V21, P1510
   Kelly DL, 2016, SEMIN ONCOL NURS, V32, P351, DOI 10.1016/j.soncn.2016.08.002
   Kim HJ, 2012, CANCER NURS, V35, pE1, DOI 10.1097/NCC.0b013e318233a811
   Kim HJ, 2005, CANCER NURS, V28, P270
   Kuo HC, 2018, RES NURS HEALTH, V41, P469, DOI 10.1002/nur.21885
   Lee SN, 2021, COMPLEMENT THER CLIN, V44, DOI 10.1016/j.ctcp.2021.101447
   Li HJ, 2021, J ALTERN COMPLEM MED, V27, P1084, DOI 10.1089/acm.2021.0133
   Li HJ, 2020, BIOL RES NURS, V22, P277, DOI 10.1177/1099800419899727
   Li L.J., 2020, Chin Mod Doct, V58, P92
   Li MY, 2023, EUR J ONCOL NURS, V66, DOI 10.1016/j.ejon.2023.102380
   Li W., 2024, W J TRAD CHIN MED, V37, P143, DOI [10.12174/j.issn.2096-9600.2024.07.34, DOI 10.12174/J.ISSN.2096-9600.2024.07.34]
   Lin L, 2021, BMJ SUPPORT PALLIAT, V11, P32, DOI 10.1136/bmjspcare-2019-001937
   Liu F.Y., 2020, Chin Mod Doct, V58, P129
   Liu QX, 2022, EUR J ONCOL NURS, V61, DOI 10.1016/j.ejon.2022.102219
   Lu P, 2024, INT IMMUNOPHARMACOL, V127, DOI 10.1016/j.intimp.2023.111415
   Matzka M, 2018, SUPPORT CARE CANCER, V26, P2685, DOI 10.1007/s00520-018-4102-8
   Miladinia M, 2017, CANCER NURS, V40, P31, DOI 10.1097/NCC.0000000000000353
   Miller AH, 2008, J CLIN ONCOL, V26, P971, DOI 10.1200/JCO.2007.10.7805
   Mohammed MA, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010035
   Qing Peng, 2020, Zhongguo Zhen Jiu, V40, P505, DOI 10.13703/j.0255-2930.20190423-k0002
   Reyes-Gibby CC, 2013, SUPPORT CARE CANCER, V21, P3117, DOI 10.1007/s00520-013-1885-5
   Rha SY, 2021, J PAIN SYMPTOM MANAG, V61, P544, DOI 10.1016/j.jpainsymman.2020.08.008
   Salvetti MD, 2022, REV ESC ENFERM USP, V56, DOI [10.1590/1980-220X-REEUSP-2021-0452en, 10.1590/1980-220x-reeusp-2021-0452en]
   Santillan-Garcia A, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419827087
   Sheikh-Wu SF, 2020, ONCOL NURS FORUM, V47, pE107, DOI 10.1188/20.ONF.E107-E119
   Snijders RAH, 2023, CANCERS, V15, DOI 10.3390/cancers15030591
   So WKW, 2020, CANCER NURS, V43, pE304, DOI 10.1097/NCC.0000000000000730
   Tan JY, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191911934
   Thong MSY, 2020, CURR TREAT OPTION ON, V21, DOI 10.1007/s11864-020-0707-5
   Trentini JF III, 2005, AM J CHINESE MED, V33, P143, DOI 10.1142/S0192415X05002746
   Utli H, 2023, EXPLORE-NY, V19, P91, DOI 10.1016/j.explore.2022.11.007
   Wang C.X.., 2017, Chin Gen Pract Nurs, V15, P1194, DOI DOI 10.3969/J.ISSN.1674-4748.2017.10.015
   Wang FQ, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.1036634
   Wang XH., 2020, INTERVENTION STUDY A
   Wang YY., 2020, EFFECT AURICULAR POI
   Weaver M T, 1985, Nurse Pract, V10, P38
   Wong WM, 2023, CANCER NURS, V46, pE70, DOI 10.1097/NCC.0000000000001048
   Wyatt G, 2015, SUPPORT CARE CANCER, V23, P3183, DOI 10.1007/s00520-015-2698-5
   Xie WX, 2023, INT J NURS STUD, V145, DOI 10.1016/j.ijnurstu.2023.104531
   Yan J.L.., 2021, Study on the Effect of Acupoint Massage on Mild to Moderate Pain in Cancer Patients Based on Holographic Theory in Chinese
   Ye YX, 2025, CANCER NURS, V48, P352, DOI 10.1097/NCC.0000000000001316
   Yeh CH, 2023, PAIN MANAG NURS, V24, P19, DOI 10.1016/j.pmn.2022.11.004
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Zhang B, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000007750
   Zhang CG., 2022, CHIN MOD DOCT, V60, P136
   Zick SM, 2016, JAMA ONCOL, V2, P1470, DOI 10.1001/jamaoncol.2016.1867
   Zick SM, 2018, JNCI CANCER SPECT, V2, DOI 10.1093/jncics/pky064
NR 62
TC 0
Z9 0
U1 4
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2768-3605
EI 2768-3613
J9 J INTEGR COMPLEMENT
JI J. Integr. Complement. Med.
PD OCT 1
PY 2025
VL 31
IS 10
BP 860
EP 875
DI 10.1089/jicm.2024.0914
EA JUN 2025
PG 16
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 8SI4O
UT WOS:001516977700001
PM 40569723
DA 2026-01-16
ER

PT J
AU Ogawa, K
   Ogawa, M
   Nishijima, K
   Tsuda, M
   Nishimura, G
AF Ogawa, Keiko
   Ogawa, Masao
   Nishijima, Koji
   Tsuda, Masaki
   Nishimura, Genichi
TI Efficacy of Contact Needle Therapy for Chemotherapy-Induced Peripheral
   Neuropathy
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID ACUPUNCTURE; PAIN; ELECTROACUPUNCTURE
AB Cancer chemotherapy-induced peripheral neuropathy (CIPN) often results in discontinuation of treatment with potentially useful anticancer drugs and may deteriorate the patient's quality of life. This study investigated the effect of contact needle therapy (CNT) on CIPN caused by responsible chemotherapeutic agents as taxanes and oxaliplatin. Six patients with CIPN were treated with CNT. The severity of CIPN was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE) version 4 and FACT/GOG-Ntx before and after CNT. After the treatment, all of the patients showed some improvement. Four patients showed apparent improvement in breakthrough pain. One of the cases had difficulty in walking because of CIPN in lower extremities, but after 2 times of CNT, he could walk without pain and could continue the chemotherapy. Although its putative mechanisms remain elusive, CNT has strong potential as an adjunctive therapy in CIPN. Well-designed clinical trials with adequate sample size and power are necessary to confirm the findings of this study.
C1 [Ogawa, Keiko] Kanazawa Univ Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Clin Japanese Oriental Kampo Med, Kanazawa, Ishikawa 9208641, Japan.
   [Ogawa, Masao] Kanazawa Med Univ Hosp, Dept Anesthesiol, Uchinada, Ishikawa 9200265, Japan.
   [Nishijima, Koji; Nishimura, Genichi] Japanese Red Cross Kanazawa Hosp, Dept Surg, Kanazawa, Ishikawa 9218162, Japan.
   [Tsuda, Masaki] Mukeido Acupuncture & Moxibust Off, Toyama 9398081, Japan.
C3 Kanazawa University; Kanazawa Medical University
RP Ogawa, K (corresponding author), Kanazawa Univ Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Clin Japanese Oriental Kampo Med, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan.
EM ikkandoo@gmail.com
OI Ogawa-Ochiai, Keiko/0000-0002-3277-0646
CR Abuaisha BB, 1998, DIABETES RES CLIN PR, V39, P115, DOI 10.1016/S0168-8227(97)00123-X
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   ANDERSSON S, 1995, MED HYPOTHESES, V45, P271, DOI 10.1016/0306-9877(95)90117-5
   Bao T, 2011, PAIN RES TREAT, V2011, DOI 10.1155/2011/920807
   Colson Kathleen, 2004, Clin J Oncol Nurs, V8, P473, DOI 10.1188/04.CJON.473-480
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Galantino MLA, 1999, J ALTERN COMPLEM MED, V5, P135, DOI 10.1089/acm.1999.5.135
   Goodnick PJ, 2000, AM J PSYCHIAT, V157, P1342, DOI 10.1176/appi.ajp.157.8.1342-a
   HAN JS, 1982, ADV BIOCHEM PSYCHOPH, V33, P369
   Hayashi K., 2010, KAMPO MED, V61, P198
   Kaley TJ, 2009, BRIT J HAEMATOL, V145, P3, DOI 10.1111/j.1365-2141.2008.07558.x
   Kaptchuk TJ, 2006, BMJ-BRIT MED J, V332, P391, DOI 10.1136/bmj.38726.603310.55
   Litscher G, 2002, LASER MED SCI, V17, P19, DOI 10.1007/s10103-002-8262-9
   LOMONACO M, 1992, J NEUROL, V239, P199, DOI 10.1007/BF00839140
   Ma SX, 2000, BRAIN RES, V855, P124, DOI 10.1016/S0006-8993(99)02379-3
   Pachman DR, 2011, CLIN PHARMACOL THER, V90, P377, DOI 10.1038/clpt.2011.115
   Pasetto LM, 2006, CRIT REV ONCOL HEMAT, V59, P159, DOI 10.1016/j.critrevonc.2006.01.001
   Phillips KD, 2004, J ALTERN COMPLEM MED, V10, P449, DOI 10.1089/1075553041323678
   Quan D., 2002, PRINCIPLES PRACTICE, P545
   ROWINSKY EK, 1995, NEW ENGL J MED, V332, P1004, DOI 10.1056/NEJM199504133321507
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Shlay JC, 1998, JAMA-J AM MED ASSOC, V280, P1590, DOI 10.1001/jama.280.18.1590
   Sioka C, 2009, CANCER CHEMOTH PHARM, V63, P761, DOI 10.1007/s00280-008-0876-6
   SJOLUND B, 1977, ACTA PHYSIOL SCAND, V100, P382, DOI 10.1111/j.1748-1716.1977.tb05964.x
   Smith F W Jr, 1992, Probl Vet Med, V4, P34
   Ulett GA, 1998, SOUTHERN MED J, V91, P1115, DOI 10.1097/00007611-199812000-00004
   Weiss R. B., 2005, CANC PRINCIPLES PRAC, P2602
   Wong Raimond, 2006, Acupunct Med, V24, P87
   World Health Organization, 2008, WHO standard acupuncture point locations in the Western Pacific region, V1st ed.
NR 29
TC 13
Z9 22
U1 0
U2 19
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 928129
DI 10.1155/2013/928129
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 158HP
UT WOS:000319960400001
PM 23762168
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Li, FF
   Zhang, LN
   Tang, F
   Liu, YC
AF Li, Fang-Fang
   Zhang, Li-Na
   Tang, Fen
   Liu, Yu-Chen
TI Randomized Controlled Trial of Wrist-Ankle Acupuncture for Postoperative
   Pharyngeal Pain in Patients Undergoing Day Surgery Thyroidectomy
SO CANCER NURSING
LA English
DT Article; Early Access
DE Day surgery; Pain; Randomized controlled trial; Thyroid cancer;
   Traditional Chinese medicine; Wrist-ankle acupuncture therapy
ID MECHANISMS; RECOVERY; QUALITY; SCALE
AB Background: Postoperative pharyngeal pain is common in patients with thyroid cancer undergoing day-case surgery, with approximately 60%-90% affected. Wrist-ankle acupuncture (WAA) offers a potential alternative but lacks clinical validation in day surgery settings. Objective: This study aimed to assess the effectiveness and safety of WAA in reducing postoperative pharyngeal pain in patients with thyroid cancer undergoing day-case surgery. Methods: Seventy-two patients undergoing thyroidectomy were randomized into the WAA experimental group (n = 36) or the control group (n = 36). The WAA experimental group received standardized care plus subcutaneous needle insertion at wrist points (Upper 1 and Upper 6) postoperatively, whereas the control group received standard care alone. Pain was assessed using the visual analog scale at 3, 4, 9, and 27 hours, and predischarge. Secondary outcomes included the Houston Pain Outcome Instrument and the 15-item Quality of Recovery scale. Results: At 9 and 27 hours post surgery, the experimental group reported significantly lower pain scores (P < .001); satisfaction with pain control was also significantly higher (P < .001). The WAA group had minor adverse events and no serious complications. Additionally, the experimental group experienced better postoperative sleep and overall health (P < .05). Conclusions: Wrist-ankle acupuncture significantly relieves postoperative sore throat in patients with thyroid cancer during day surgery. This work establishes a foundation for integrating WAA into modern surgical recovery pathways. However, larger randomized controlled trials are needed to determine effectiveness across different institutions and populations. Implications for Practice: Wrist-ankle acupuncture offers a nonpharmacological alternative for pain management in thyroid cancer surgery. Further studies are needed to confirm its broader applicability and effectiveness in diverse patient populations.
C1 [Li, Fang-Fang; Zhang, Li-Na; Tang, Fen] Anhui Med Univ, Affiliated Hosp, Ambulatory Surg Ctr, Hefei, Peoples R China.
   [Liu, Yu-Chen] Anhui Med Univ, Affiliated Hosp, Dept Otolaryngol Head & Neck Surg, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Liu, YC (corresponding author), Anhui Med Univ, Affiliated Hosp, Dept Otolaryngol Head & Neck Surg, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China.
EM 3091305084@qq.com; 81147677@qq.com; 13855178172@163.com;
   136856076@qq.com
RI Li, Fangfang/OUJ-5573-2025
CR Bérubé M, 2024, PAIN, V165, pE162, DOI 10.1097/j.pain.0000000000003288
   Boucai L, 2024, JAMA-J AM MED ASSOC, V331, P425, DOI 10.1001/jama.2023.26348
   Cao HT, 2023, CHIN J INTEGR MED, V29, P253, DOI 10.1007/s11655-022-3463-5
   Chou RG, 2022, THYROID, V32, P351, DOI 10.1089/thy.2021.0539
   D'Orazi V, 2019, BMC SURG, V18, DOI 10.1186/s12893-018-0447-7
   da Costa BR, 2021, OSTEOARTHR CARTILAGE, V29, P304, DOI 10.1016/j.joca.2020.10.004
   de la Fuente Bartolome Marta, 2022, Cir Esp (Engl Ed), V100, P601, DOI [10.1016/j.cireng.2022.06.018, 10.1016/j.cireng.2022.06.018]
   El-Boghdadly K, 2016, ANAESTHESIA, V71, P706, DOI 10.1111/anae.13438
   Fei YT, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj-2021-064345
   Gao LL, 2025, EUR ARCH OTO-RHINO-L, V282, P427, DOI 10.1007/s00405-024-08943-z
   Goudman L, 2024, ANAESTHESIA, V79, P128, DOI 10.1111/anae.16151
   Han XR, 2023, J INTEGR MED-JIM, V21, P168, DOI 10.1016/j.joim.2023.02.001
   Huang XA, 2025, ENDOSCOPY, V57, P158, DOI 10.1055/a-2373-0513
   Jensen MP, 2024, ANAESTHESIA, V79, P114, DOI 10.1111/anae.16150
   Jin YS, 2022, EUR ARCH OTO-RHINO-L, V279, P5877, DOI 10.1007/s00405-022-07513-5
   John H, 2000, J UROLOGY, V163, P1761, DOI 10.1016/S0022-5347(05)67537-4
   Kim D, 2019, CAN J ANESTH, V66, P934, DOI 10.1007/s12630-019-01371-2
   Lang-Illievich K, 2020, BRIT J ANAESTH, V124, pE228, DOI 10.1016/j.bja.2020.02.011
   Lin JG, 2008, AM J CHINESE MED, V36, P635, DOI 10.1142/S0192415X08006107
   Liu YQ, 2015, CHIN J INTEGR MED, V21, P697, DOI 10.1007/s11655-014-2009-x
   March JP, 2022, JAMA OTOLARYNGOL, V148, P561, DOI 10.1001/jamaoto.2022.0952
   Mazzotta E, 2023, FRONT PHARMACOL, V14, DOI 10.3389/fphar.2023.1284071
   Mongelli MN, 2020, SURGERY, V167, P631, DOI 10.1016/j.surg.2019.11.014
   Myles PS, 2022, BRIT J ANAESTH, V128, P1029, DOI 10.1016/j.bja.2022.03.009
   Nabhan F, 2021, INT J CANCER, V149, P984, DOI 10.1002/ijc.33690
   Nakanishi H, 2024, AM J SURG, V236, DOI 10.1016/j.amjsurg.2024.02.037
   Rao SN, 2023, BEST PRACT RES CL EN, V37, DOI 10.1016/j.beem.2022.101678
   Shi P, 2020, IEEE T BIOMED CIRC S, V14, P1431, DOI 10.1109/TBCAS.2020.3039063
   Sorrenti S, 2023, CANCERS, V15, DOI 10.3390/cancers15123102
   Valentine S, 2021, ANN EMERG MED, V77, P82, DOI 10.1016/j.annemergmed.2020.03.029
   Van den Eynde F, 2023, LANGENBECK ARCH SURG, V408, DOI 10.1007/s00423-023-02982-6
   Wang Qiong, 2017, Zhongguo Zhen Jiu, V37, P509, DOI 10.13703/j.0255-2930.2017.05.016
   Want SC, 2024, BODY IMAGE, V51, DOI 10.1016/j.bodyim.2024.101788
   Wattier JM, 2016, ANAESTH CRIT CARE PA, V35, P197, DOI 10.1016/j.accpm.2015.10.006
   World Health Organization, WHO benchmarks for the training of acupuncture
   Xu JS, 2013, NEURAL REGEN RES, V8, P2633, DOI 10.3969/j.issn.1673-5374.2013.28.005
   Xu TF, 2024, SURG ENDOSC, V38, P1995, DOI 10.1007/s00464-024-10689-y
   Xue FR, 2025, MEDICINE, V104, DOI [10.1097/md.0000000000041837, 10.1097/MD.0000000000041837]
   Yao W, 2013, J TRADIT CHIN MED, V33, P538, DOI 10.1016/S0254-6272(13)60162-4
   Yoon S, 2020, BRIT J ANAESTH, V125, P614, DOI 10.1016/j.bja.2020.06.040
   Zeng K, 2014, AM J CHINESE MED, V42, P289, DOI 10.1142/S0192415X14500190
   Zhang CP, 2020, CHIN MED-UK, V15, DOI 10.1186/s13020-020-0289-y
   Zhang EW, 2023, PAIN, V164, P2642, DOI 10.1097/j.pain.0000000000003004
   Zhang ML, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/1451342
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zhou Q, 2023, J ACUPUNCT TUINA SCI, V21, P368, DOI 10.1007/s11726-023-1394-0
NR 46
TC 0
Z9 0
U1 5
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD 2025 SEP 29
PY 2025
DI 10.1097/NCC.0000000000001547
EA SEP 2025
PG 8
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA 8AS5X
UT WOS:001584184300001
PM 41026681
DA 2026-01-16
ER

PT J
AU Ernst, E
AF Ernst, Edzard
TI Complementary therapies for supportive cancer care
SO SUPPORTIVE CARE IN CANCER
LA English
DT Editorial Material
ID ACUPUNCTURE; EFFICACY; MASSAGE; RELIEF; PAIN
C1 Univ Exeter, Peninsula Med Sch, Exeter EX2 4NT, Devon, England.
C3 University of Exeter
RP Ernst, E (corresponding author), Univ Exeter, Peninsula Med Sch, 25 Victoria Pk Rd, Exeter EX2 4NT, Devon, England.
EM Edzard.Ernst@pms.ac.uk
CR Bardia A, 2006, J CLIN ONCOL, V24, P5457, DOI 10.1200/JCO.2006.08.3725
   Bradt J, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007169.pub3
   Conn VS, 2006, SUPPORT CARE CANCER, V14, P699, DOI 10.1007/s00520-005-0905-5
   Cramp F, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006145.pub2
   Dimeo F, 2004, DEUT Z SPORTMED, V55, P177
   Ernst E, 2008, J POSTGRAD MED, V54, P214, DOI 10.4103/0022-3859.41806
   Ernst E, 2009, SUPPORT CARE CANCER, V17, P333, DOI 10.1007/s00520-008-0569-z
   Ernst E., 2006, DESKTOP GUIDE COMPLE
   Fellowes D., 2004, COCHRANE DB SYST REV, DOI [DOI 10.1002/14651858, 10.1002/14651858.CD002287.pub2, DOI 10.1002/14651858.CD002287.PUB2]
   Klein Joan, 2004, Br J Community Nurs, V9, P383
   Lee H, 2005, EUR J PAIN, V9, P437, DOI 10.1016/j.ejpain.2004.10.004
   Lee MS, 2007, ACTA ONCOL, V46, P717, DOI 10.1080/0284160701261584
   Lee MS, 2007, SUPPORT CARE CANCER, V15, P597, DOI 10.1007/s00520-007-0221-3
   Lee MS, 2009, SUPPORT CARE CANCER, V17, P763, DOI 10.1007/s00520-009-0589-3
   Lee MS, 2009, BREAST CANCER RES TR, V115, P497, DOI 10.1007/s10549-008-0230-z
   Molassiotis A, 2009, COMPLEMENT THER MED, V17, P92, DOI 10.1016/j.ctim.2008.11.002
   Roffe L, 2005, PSYCHO-ONCOLOGY, V14, P607, DOI 10.1002/pon.889
   Roffe L, 2004, J CLIN ONCOL, V22, P4418, DOI 10.1200/JCO.2004.02.034
   Seers HE, 2009, SUPPORT CARE CANCER, V17, P1159, DOI 10.1007/s00520-008-0565-3
   Vickers AJ, 1996, J ROY SOC MED, V89, P303, DOI 10.1177/014107689608900602
   Witt CM, 2009, FORSCH KOMPLEMENTMED, V16, P292, DOI 10.1159/000234904
NR 21
TC 4
Z9 4
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD NOV
PY 2010
VL 18
IS 11
BP 1365
EP 1366
DI 10.1007/s00520-010-0991-x
PG 2
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 654QG
UT WOS:000282182500001
PM 20803036
OA Bronze
DA 2026-01-16
ER

PT J
AU Zhang, WN
   Xu, JN
   Wan, YX
   Yang, M
   Huang, JC
AF Zhang, Weina
   Xu, Jingnan
   Wan, Yuxiang
   Yang, Ming
   Huang, Jinchang
TI Moxibustion combined with guasha therapy for recurrent neutropenia
   following multiple cycles of chemotherapy of ovarian cancer: A case
   report
SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
LA English
DT Article
DE Moxibustion; Guasha therapy; Neutropenia; Chemotherapy-induced
   myelosuppression; Case report
AB Neutropenia, a common side effect of chemotherapy for ovarian cancer, was observed in a 47-year-old female patient undergoing a six-cycle chemotherapy regimen. She experienced recurrent neutropenia and leukopenia but refused granulocyte colony-stimulating factor (G-CSF) due to severe bone pain and high costs. Moxibustion combined with guasha therapy (MGT) was administered each time neutropenia occurred. The treatment involved guasha therapy on the bladder meridian (BL) and the governor vessel (GV), followed by moxibustion at Zhongwan (CV 12), Guanyuan (CV 4), and Shenzhu (GV 12) points over 2-3 days. This approach led to the recovery of neutrophil and leukocyte counts, enabling the patient to complete six chemotherapy cycles without G-CSF. These findings suggest that MGT may enhance neutrophil and leukocyte counts in patients with chemotherapy-induced myelosuppression, presenting a potential alternative for those intolerant to G-CSF. However, further high-quality research is needed to confirm its efficacy.
C1 [Zhang, Weina; Xu, Jingnan; Wan, Yuxiang; Yang, Ming; Huang, Jinchang] Beijing Univ Chinese Med, Affiliated Hosp 3, 51 Xiaoguan St, Beijing 100029, Peoples R China.
C3 Beijing University of Chinese Medicine
RP Huang, JC (corresponding author), Beijing Univ Chinese Med, Affiliated Hosp 3, 51 Xiaoguan St, Beijing 100029, Peoples R China.
EM zryhhuang@163.com
RI Yuxiang, Wan/AAU-9771-2020; Xu, Jingnan/JAX-8510-2023
CR Armstrong Deborah K, 2022, J Natl Compr Canc Netw, V20, P972, DOI [10.6004/jnccn.2022.0047, 10.6004/jnccn.2022.0047]
   Choi TY, 2015, SUPPORT CARE CANCER, V23, P1819, DOI 10.1007/s00520-014-2530-7
   Chu ECP, 2021, J FAM MED PRIM CARE, V10, P2757, DOI 10.4103/jfmpc.jfmpc_360_21
   Deng HY, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/379291
   Griffiths EA, 2022, J NATL COMPR CANC NE, V20, P436, DOI 10.6004/jnccn.2022.0026
   Guastalla JP III, 2003, BRIT J CANCER, V89, pS16, DOI 10.1038/sj.bjc.6601496
   Guo JH, 2013, Chin Arch Tradit Chin Med, V31, P159, DOI [10.13193/j.archtcm.2013.01.163.guojh.081, DOI 10.13193/J.ARCHTCM.2013.01.163.GUOJH.081]
   Lee MS, 2010, BMC CANCER, V10, DOI 10.1186/1471-2407-10-130
   Organization WH, 2022, WHO International Standard Terminologies On Traditional Chinese medicine
   Qiu XW, 2021, Liaoning J Tradit Chin Med, V48, P162
   Riley DS, 2017, J CLIN EPIDEMIOL, V89, P218, DOI 10.1016/j.jclinepi.2017.04.026
   Rubenstein EB, 2000, INT J ANTIMICROB AG, V16, P117, DOI 10.1016/S0924-8579(00)00214-4
   Starodub AN, 2015, CLIN CANCER RES, V21, P3870, DOI 10.1158/1078-0432.CCR-14-3321
   Wu Yu, 2020, Zhen Ci Yan Jiu, V45, P83, DOI 10.13702/j.1000-0607.1900946
   Zhu ZG, 2024, J INTEGR MED-JIM, V22, P12, DOI 10.1016/j.joim.2023.11.006
NR 15
TC 1
Z9 2
U1 2
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-8307
EI 1878-7541
J9 EXPLORE-NY
JI Explore-J Sci. Heal.
PD SEP-OCT
PY 2024
VL 20
IS 5
AR 103031
DI 10.1016/j.explore.2024.103031
EA JUL 2024
PG 4
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA K7K4Q
UT WOS:001345625100001
PM 38986288
DA 2026-01-16
ER

PT J
AU Hershman, DL
   Unger, JM
   Crew, K
AF Hershman, Dawn L.
   Unger, Joseph M.
   Crew, Katherine
TI Acupuncture for Aromatase Inhibitor-Related Joint Pain Among Breast
   Cancer Patients Reply
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Letter
C1 [Hershman, Dawn L.; Crew, Katherine] Columbia Univ, Med Ctr, 161 Ft Washington Ave,10-1068, New York, NY 10032 USA.
   [Unger, Joseph M.] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
C3 Columbia University; Fred Hutchinson Cancer Center
RP Hershman, DL (corresponding author), Columbia Univ, Med Ctr, 161 Ft Washington Ave,10-1068, New York, NY 10032 USA.
EM dlh23@cumc.columbia.edu
RI Unger, Joseph/O-7457-2019; Hershman, Dawn/AAG-2114-2020
FU NCI NIH HHS [UG1 CA189974] Funding Source: Medline; National Cancer
   Institute [UG1CA189974] Funding Source: NIH RePORTER
CR [Anonymous], J EVID BASED MED
   Farrar JT, 2001, PAIN, V94, P149, DOI 10.1016/S0304-3959(01)00349-9
   Greenlee H, 2015, J ACUPUNCT MERIDIAN, V8, P152, DOI 10.1016/j.jams.2015.03.006
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Kroenke K, 2010, JAMA-J AM MED ASSOC, V304, P163, DOI 10.1001/jama.2010.944
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
NR 6
TC 10
Z9 10
U1 0
U2 16
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD DEC 4
PY 2018
VL 320
IS 21
BP 2270
EP 2271
DI 10.1001/jama.2018.16744
PG 2
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HD4MB
UT WOS:000452500600023
PM 30512095
DA 2026-01-16
ER

PT J
AU Olson, EA
   Metzger, AK
   Mallory, MJ
   Mackey, RM
AF Olson, Emily A.
   Metzger, Abbey K.
   Mallory, Molly J.
   Mackey, Regina M.
TI Opioid-Induced Constipation and Acupuncture: A Case Discussion
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Article
DE Key Acupuncture; cancer; opioid-induced constipation; palliative
   medicine; opioid
ID MANAGEMENT; SAFETY; PAIN
AB Background. Use of acupuncture for treatment of functional constipation is well studied; however, studies examining use of acupuncture for opioid-induced constipation are limited. Case Description. A 70-year-old woman with newly diagnosed multiple myeloma discovered after presentation to the emergency room with severe back pain. Pain management required use of opioids, escalating to effect. Hospital course was complicated by opioid-induced constipation causing abdominal pain, nausea, and ileus despite aggressive titration of stimulant and osmotic laxatives as well as administration of suppositories and enemas on multiple occasions. Prior to nasogastric tube placement for the ileus, the patient requested acupuncture treatment in attempt to relieve constipation. Shortly after acupuncture session, patient passed multiple stools with improvement in abdominal pain and nausea and avoidance of nasogastric tube. Conclusion. Acupuncture for opioid-induced constipation may provide symptom relief through use of nonpharmacologic interventions; however, further studies are needed to determine the optimal therapeutic approach. J Pain Symptom Manage 2021;62:876-880. (c) 2021 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Olson, Emily A.; Metzger, Abbey K.; Mackey, Regina M.] Mayo Clin, Ctr Palliat Med, Gen Internal Med, Rochester, MN 55905 USA.
   [Mallory, Molly J.] Mayo Clin, Integrat Med & Hlth, Gen Internal Med, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic
RP Olson, EA (corresponding author), Mayo Clin, Ctr Palliat Med, Dept Internal Med, 200 First St SW, Rochester, MN 55905 USA.
EM Olson.emily3@mayo.edu
OI Olson, Emily/0000-0002-5001-8757
CR Briggs JP, 2017, JAMA-J AM MED ASSOC, V317, P2489, DOI 10.1001/jama.2017.7214
   Chan MWC, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03272-0
   Cybularz PA, 2015, MED ACUPUNCT, V27, P224, DOI 10.1089/acu.2015.1099
   Eigenschink M, 2020, WIEN KLIN WOCHENSCHR, V132, P260, DOI 10.1007/s00508-020-01625-w
   Ernst E, 2011, PAIN, V152, P755, DOI 10.1016/j.pain.2010.11.004
   Fallon M, 2018, ANN ONCOL, V29, P166, DOI 10.1093/annonc/mdy152
   Ketwaroo Gyanprakash A, 2013, Curr Gastroenterol Rep, V15, P344, DOI 10.1007/s11894-013-0344-2
   Kouch DJ, 2011, ACUPUNCTURE DESK REF, V2
   Ladas EJ, 2010, SUPPORT CARE CANCER, V18, P1487, DOI 10.1007/s00520-010-0926-6
   Langevin HM, 2001, J APPL PHYSIOL, V91, P2471, DOI 10.1152/jappl.2001.91.6.2471
   Lau CHY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002901
   Lee HY, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2243-4
   Liu ZS, 2016, ANN INTERN MED, V165, P761, DOI 10.7326/M15-3118
   MacPherson H, 2004, QUAL SAF HEALTH CARE, V13, P349, DOI 10.1136/qshc.2003.009134
   Müller-Lissner S, 2017, PAIN MED, V18, P1837, DOI 10.1093/pm/pnw255
   National Comprehensive Cancer Network, PALL CAR VERS 1 2020
   Pergolizzi JV, 2020, DRUG DES DEV THER, V14, P1009, DOI 10.2147/DDDT.S221278
   Qin MX, 2010, Journal of Qiqihar Medical College, V31, P3921, DOI DOI 10.3969/J.ISSN.1002-1256.2010.24.039
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Samolsky Dekel Boaz Gedaliahu, 2019, J Opioid Manag, V15, P375, DOI [10.5055/jom.2019.0527, 10.5055/jom.2019.0527]
   Thompson LMA, 2016, ASCO POST
   White Adrian., 2006, Acupuncture in Medicine, V24, pS53, DOI [10.1136/aim.24.Suppl.53, DOI 10.1136/AIM.24.SUPPL.53]
   Wu J, 2014, MEDICINE, V93, DOI 10.1097/MD.0000000000000284
   Xu XH, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-423
   Yang XY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187723
   Yin T, 2019, TRIALS, V20, DOI 10.1186/s13063-019-3410-8
   Zhang Feng-Li, 2009, Zhongguo Zhong Xi Yi Jie He Za Zhi, V29, P922
   Zheng H, 2018, NEUROGASTROENT MOTIL, V30, DOI 10.1111/nmo.13307
   Zhou J, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/7491281
   Zhou SL, 2017, ACUPUNCT MED, V35, P324, DOI 10.1136/acupmed-2016-011127
NR 30
TC 3
Z9 4
U1 2
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD OCT
PY 2021
VL 62
IS 4
BP 876
EP 880
DI 10.1016/j.jpainsymman.2021.01.135
EA SEP 2021
PG 5
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA WC6ML
UT WOS:000704370200025
PM 33556492
OA Bronze
DA 2026-01-16
ER

PT J
AU Pei, LX
   Wang, G
   Yang, SH
   Zhou, SX
   Xu, TS
   Zhou, J
   Zhang, W
   Lu, KX
   Hu, LY
   Wang, Y
   Wang, K
   You, DF
   Wu, YQ
   Li, L
   Guo, J
   Sun, JH
AF Pei, Lixia
   Wang, Gang
   Yang, Sihao
   Zhou, Shuxin
   Xu, Tianshu
   Zhou, Jia
   Zhang, Wei
   Lu, Kaixin
   Hu, Linyan
   Wang, Yang
   Wang, Ke
   You, Dongfang
   Wu, Yaqian
   Li, Li
   Guo, Jing
   Sun, Jianhua
TI Electroacupuncture Reduces Duration of Postoperative Ileus After
   Laparoscopic Gastrectomy for Gastric Cancer: A Multicenter Randomized
   Trial
SO GASTROENTEROLOGY
LA English
DT Article
DE Gastric Cancer; Postoperative Ileus; Acupuncture; Recovery Time;
   Gastrointestinal Motility
ID QUALITY-OF-LIFE; ACUPUNCTURE; SURGERY; RECOVERY; PAIN
AB BACKGROUND & AIMS: Electroacupuncture (EA) may reduce the duration of postoperative ileus (POI) after laparoscopic gastrectomy for gastric cancer, although evidence is limited. We investigated the efficacy of EA in reducing POI duration and enhancing gastrointestinal (GI) recovery in patients undergoing laparoscopic surgery for gastric cancer. METHODS: This multicenter randomized trial was conducted at 7 hospitals in China, enrolling 585 participants who underwent laparoscopic resection for gastric cancer from October 27, 2021, to December 21, 2023. Participants received perioperative standard care and were randomized to 4 sessions of EA, 4 sessions of sham EA (SA), or standard care only. The primary outcome was the time to first flatus. Secondary outcomes included time to first defecation, dietary recovery, quality of life, postoperative mobilization, and duration of hospital stay. RESULTS: A total of 578 participants were in the full analysis set. EA exhibited a shorter time to first flatus compared with both SA and standard care, with differences of-12.96 hours (95% confidence interval (CI), -19.17 to -6.75; P < .001) and-24.46 hours (95% CI, -30.61 to -18.30; P < .001), respectively. Similarly, EA significantly reduced the time to first defecation: -15.41 hours (95% CI, -27.73 to -3.09; P=.007) vs SA;-24.66 hours (95% CI, -36.76 to -12.55; P < .001) vs standard care. Incidence of prolonged POI was significantly lower in the EA group than in the SA and standard care groups, with group differences of -0.41 (95% CI, -0.66 to -0.16; P < .001) and -0.56 (95% CI, -0.82 to -0.31; P < .001), respectively. No severe adverse events were reported. CONCLUSIONS: EA was superior to SA and standard care only for reducing POI duration and the risk of prolonged POI in patients undergoing laparoscopic gastrectomy for gastric cancer.
C1 [Pei, Lixia; Hu, Linyan; Li, Li; Guo, Jing; Sun, Jianhua] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Clin Med Coll 1, Dept Acupuncture & Rehabil,Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
   [Wang, Gang] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Gen Surg, Affiliated Hosp, Nanjing, Jiangsu, Peoples R China.
   [Yang, Sihao] Sichuan Univ, West China Hosp, Acupuncture Ctr, Chengdu, Sichuan, Peoples R China.
   [Yang, Sihao] West China Hosp, Yibin Hosp, Dept Integrated Tradit Chinese & Western Med, Yibin Peoples Hosp 2, Yibin, Sichuan, Peoples R China.
   [Zhou, Shuxin] Wenzhou Med Univ, Dept Acupuncture & Phys Therapy, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China.
   [Xu, Tianshu; Wang, Yang] Nanjing Univ, Sch Med, Dept Tradit Chinese Med, Affiliated Hosp,Nanjing Drum Tower Hosp, Nanjing, Jiangsu, Peoples R China.
   [Zhou, Jia; Wang, Ke] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Acupuncture Anesthesia Clin Res Inst, Shanghai, Peoples R China.
   [Zhang, Wei] Hunan Univ Chinese Med, Dept Acupuncture Moxibust & Tuina, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.
   [Lu, Kaixin] Subei Peoples Hosp Jiangsu Prov, Dept Acupuncture, Yangzhou, Jiangsu, Peoples R China.
   [You, Dongfang; Wu, Yaqian] Nanjing Med Univ, Sch Publ Hlth, Dept Biostat, Nanjing, Jiangsu, Peoples R China.
   [Guo, Jing] Nanjing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Sichuan University; Wenzhou Medical University; Nanjing
   University; Shanghai University of Traditional Chinese Medicine; Hunan
   University of Chinese Medicine; Nanjing Medical University; Nanjing
   University of Chinese Medicine
RP Sun, JH (corresponding author), Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Clin Med Coll 1, Dept Acupuncture & Rehabil,Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.; Guo, J (corresponding author), Nanjing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China.
EM janiceguo@njucm.edu.cn; fsyy00657@njucm.edu.cn
RI Xu, Tianshu/LDF-0567-2024; You, Dongfang/MSY-2857-2025; Guo,
   Jing/MHQ-5739-2025
FU Key Social Development Project of Jiangsu Provincial Science and
   Technology Department [BE2020788]; National Natural Science Foundation
   of China [82174489, 82274630, 82405589]
FX This work was supported by the Key Social Development Project of Jiangsu
   Provincial Science and Technology Department (BE2020788); and the
   National Natural Science Foundation of China (82174489, 82274630, and
   82405589) .
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   Blazeby JM, 2004, EUR J CANCER, V40, P2260, DOI 10.1016/j.ejca.2004.05.023
   Boeckxstaens GE, 2009, GUT, V58, P1300, DOI 10.1136/gut.2008.169250
   Bray F, 2024, CA-CANCER J CLIN, V74, P229, DOI 10.3322/caac.21834
   Chae HD, 2016, J ALTERN COMPLEM MED, V22, P465, DOI 10.1089/acm.2015.0161
   Chen HT, 2024, INT J SURG, V110, P1113, DOI 10.1097/JS9.0000000000000848
   Chen KB, 2019, INT J SURG, V70, P93, DOI 10.1016/j.ijsu.2019.08.034
   Chen KB, 2018, WORLD J GASTRO SURG, V10, P13, DOI 10.4240/wjgs.v10.i2.13
   Fei YT, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj-2021-064345
   Guerrini GP, 2020, INT J SURG, V82, P210, DOI 10.1016/j.ijsu.2020.07.053
   Han BF, 2024, J NATL CANCER CTR, V4, P47, DOI 10.1016/j.jncc.2024.01.006
   He FF, 2024, LANCET REG HEALTH-W, V44, DOI 10.1016/j.lanwpc.2023.101003
   Hersberger L, 2020, CLIN NUTR, V39, P2720, DOI 10.1016/j.clnu.2019.11.041
   Jin T, 2023, SURGERY, V173, P375, DOI 10.1016/j.surg.2022.10.016
   Jung SY, 2017, J GASTRIC CANCER, V17, P11
   Kong Q, 2024, INT J SURG, V110, P5713, DOI 10.1097/JS9.0000000000001641
   Lee A, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003281.pub4
   Lou SH, 2022, INT J SURG, V102, DOI 10.1016/j.ijsu.2022.106678
   Murakami H, 2019, J NEUROGASTROENTEROL, V25, P286, DOI 10.5056/jnm18094
   Namikawa T, 2021, JGH OPEN, V5, P454, DOI 10.1002/jgh3.12515
   Ng SSM, 2013, GASTROENTEROLOGY, V144, P307, DOI 10.1053/j.gastro.2012.10.050
   Qiu GT, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5594263
   Reichert M, 2024, INT J SURG, V110, P4329, DOI 10.1097/JS9.0000000000001393
   Sun Y, 2008, BRIT J ANAESTH, V101, P151, DOI 10.1093/bja/aen146
   Sun YJ, 2021, ANN INTERN MED, V174, P1357, DOI 10.7326/M21-1814
   van Bree SHW, 2012, NAT REV GASTRO HEPAT, V9, P675, DOI 10.1038/nrgastro.2012.134
   Vather R, 2013, J GASTROINTEST SURG, V17, P962, DOI 10.1007/s11605-013-2148-y
   Vilz TO, 2017, DTSCH ARZTEBL INT, V114, P508, DOI 10.3238/arztebl.2017.0508
   Wang CJ, 2021, GASTRIC CANCER, V24, P232, DOI 10.1007/s10120-020-01106-z
   Wang LP, 2022, MED ACUPUNCT, V34, P371, DOI 10.1089/acu.2021.0085
   Wang Y, 2023, JAMA SURG, V158, P20, DOI 10.1001/jamasurg.2022.5674
   Xu SB, 2020, BMJ-BRIT MED J, V368, DOI 10.1136/bmj.m697
   Yan SY, 2023, UNITED EUR GASTROENT, V11, P564, DOI 10.1002/ueg2.12421
   Yang JW, 2022, ECLINICALMEDICINE, V49, DOI 10.1016/j.eclinm.2022.101472
   You XL, 2018, J CANCER, V9, P2266, DOI 10.7150/jca.24767
   Yuan L, 2024, J GASTROEN HEPATOL, V39, P2060, DOI 10.1111/jgh.16670
   Zhang WL, 2022, AM J CHINESE MED, V50, P961, DOI 10.1142/S0192415X22500392
   Zhang ZD, 2014, ACUPUNCT MED, V32, P223, DOI 10.1136/acupmed-2013-010490
   Zhu J, 2022, ACUPUNCT MED, V40, P415, DOI 10.1177/09645284221076517
NR 39
TC 18
Z9 19
U1 19
U2 30
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD JUL
PY 2025
VL 169
IS 1
BP 73
EP 84
DI 10.1053/j.gastro.2025.02.006
EA JUN 2025
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 5XA4C
UT WOS:001546358900006
PM 39978558
DA 2026-01-16
ER

PT J
AU Grant, SJ
   Kwon, K
   Naehrig, D
   Asher, R
   Lacey, J
AF Grant, Suzanne J.
   Kwon, Ki
   Naehrig, Diana
   Asher, Rebecca
   Lacey, Judith
TI Characteristics and Symptom Burden of Patients Accessing Acupuncture
   Services at a Cancer Hospital
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE integrative oncology; acupuncture; ESAS; patient report outcome
   measures; cancer; symptom clusters
ID ALTERNATIVE MEDICINE; ASSESSMENT SCALE; BREAST-CANCER; COMPLEMENTARY;
   CARE; MANAGEMENT; PAIN; ONCOLOGY; FATIGUE
AB Background:
   Patients with cancer are often impacted by a significant symptom burden. Cancer hospitals increasingly recognize the value of complementary and integrative therapies to support the management of cancer related symptoms. The aim of this study is to provide a better understanding of the demographic characteristics and symptoms experienced by cancer patients who access acupuncture services in a tertiary hospital in Australia.
   Methods:
   A retrospective audit was conducted of patients that presented to the acupuncture service at Chris O'Brien Lifehouse between July 2017 and December 2018. Edmonton Symptom Assessment Scale (ESAS) and Measure Yourself Concerns and Wellbeing (MYCaW) outcome measures were used. The quantitative data was analyzed using descriptive statistics and Principal Component Analysis.
   Results:
   A total of 127 inpatients and outpatients (mean age 55, range 19-85) were included with 441 individual surveys completed (264 ESAS, 177 MYCaW). Patients were predominantly female (76.8%) and breast cancer was the most prevalent primary diagnosis (48%). The most prevalent symptoms in the ESAS were sleep problems (88.6%), fatigue (88.3%), lack of wellbeing (88.1%), and memory difficulty (82.6%). Similarly, symptoms with the highest mean scores were numbness, fatigue, sleep problems and hot flushes, whilst neuropathy, and hot flashes were scored as the most severe (score >= 7) by patients. Cluster analysis yielded 3 symptom clusters, 2 included "physical symptoms" (pain, sleep problems, fatigue and numbness/neuropathy), and (nausea, appetite, general well-being), whilst the third included "psychological" symptoms (anxiety, depression, spiritual pain, financial distress). The most frequent concerns expressed by patients (MyCaW) seeking acupuncture were side effects of chemotherapy (24.6%) and pain (20.8%).
   Conclusion:
   This audit highlights the most prevalent symptoms, the symptoms with the greatest burden and the types of patients that receive acupuncture services at an Australian tertiary hospital setting. The findings of this audit provide direction for future acupuncture practices and research in hospital settings.
C1 [Grant, Suzanne J.; Kwon, Ki; Lacey, Judith] Western Sydney Univ, NICM Hlth Res Inst, Locked Bag 1797, Penrith, NSW 2751, Australia.
   [Grant, Suzanne J.; Naehrig, Diana; Lacey, Judith] Chris OBrien Comprehens Canc Ctr, Camperdown, NSW, Australia.
   [Naehrig, Diana; Lacey, Judith] Univ Sydney, Sydney, NSW, Australia.
   [Asher, Rebecca] Natl Hlth Med Res Council, Sydney, NSW, Australia.
C3 Western Sydney University; University of Sydney; University of Sydney
RP Grant, SJ (corresponding author), Western Sydney Univ, NICM Hlth Res Inst, Locked Bag 1797, Penrith, NSW 2751, Australia.
EM s.grant@westernsydney.edu.au
RI ; Lacey, Judith/AAI-5754-2021; Grant, Suzanne Jane/JTT-6993-2023;
   Naehrig, Diana/J-4940-2019
OI Kwon, Ki Kyung/0009-0007-1295-8549; Lacey, Judith/0000-0002-3751-406X;
   Grant, Suzanne Jane/0000-0002-9491-203X; 
CR Amichai T, 2012, EUR J ONCOL NURS, V16, P520, DOI 10.1016/j.ejon.2012.01.004
   [Anonymous], 2005, From cancer patient to cancer survivor: lost in transition
   Cotler HB, 2015, MOJ Orthopedics & Rheumatology, V2, DOI [10.15406/mojor.2015.02.00068, 10.15406/mojor.2015.02.00068, DOI 10.15406/MOJOR.2015.02.00068]
   Bell RM, 2010, CLIN J ONCOL NURS, V14, P365, DOI 10.1188/10.CJON.365-370
   Ben-Arye E, 2018, EXPLORE-NY, V14, P289, DOI 10.1016/j.explore.2017.09.012
   Chang VT, 2000, CANCER, V88, P2164, DOI 10.1002/(SICI)1097-0142(20000501)88:9<2164::AID-CNCR24>3.0.CO;2-5
   Cheng CS, 2017, SUPPORT CARE CANCER, V25, P3807, DOI 10.1007/s00520-017-3812-7
   Cheng K.K. F., 2005, Clinical Effectiveness in Nursing, V9, P154
   Cheung WY, 2011, SUPPORT CARE CANCER, V19, P417, DOI 10.1007/s00520-010-0865-2
   Choi TY, 2017, INTEGR CANCER THER, V16, P135, DOI 10.1177/1534735416664172
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Cleeland CS, 2000, CANCER-AM CANCER SOC, V89, P1634, DOI 10.1002/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO;2-V
   Dodd MJ, 2010, EUR J ONCOL NURS, V14, P101, DOI 10.1016/j.ejon.2009.09.005
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Dos Santos S, 2010, MED ACUPUNCT, V22, P81, DOI 10.1089/acu.2009.0730
   Ezzo JM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002285.pub2
   Fan G, 2007, Curr Oncol, V14, P173, DOI 10.3747/co.2007.145
   Garcia MK, 2018, INTEGR CANCER THER, V17, P148, DOI 10.1177/1534735416685403
   Garcia MK, 2014, CURR ONCOL REP, V16, DOI 10.1007/s11912-014-0418-9
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Grant SJ, 2019, SUPPORT CARE CANCER, V27, P2069, DOI 10.1007/s00520-018-4460-2
   Greenlee Heather, 2014, Journal of the National Cancer Institute Monographs, P346, DOI 10.1093/jncimonographs/lgu041
   Health, 2020, DEF INT MED HLTH
   Horneber M, 2012, INTEGR CANCER THER, V11, P187, DOI 10.1177/1534735411423920
   Hui D, 2015, CANCER-AM CANCER SOC, V121, P3027, DOI 10.1002/cncr.29437
   Javdan B, 2015, J ACUPUNCT MERIDIAN, V8, P115, DOI 10.1016/j.jams.2015.03.005
   Kremser T, 2008, BREAST, V17, P387, DOI 10.1016/j.breast.2007.12.006
   Lau CHY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002901
   Li K, 2019, CURR ONCOL, V26, pE147, DOI 10.3747/co.26.4261
   Lopez G, 2018, J CANCER, V9, P3613, DOI 10.7150/jca.26527
   Lu WD, 2013, CURR PAIN HEADACHE R, V17, DOI 10.1007/s11916-013-0321-3
   McKeon C., 2013, AJACM, V8, P2
   Minasian LM, 2007, J CLIN ONCOL, V25, P5128, DOI 10.1200/JCO.2007.12.6672
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Ogawa K, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/928129
   Paley CA, 2011, BMJ SUPPORT PALLIAT, V1, P51, DOI [10.1136/bmjspcare-2011-000022, 10.1136/bmjspcare-2011-000066]
   Paterson C, 2007, COMPLEMENT THER MED, V15, P38, DOI 10.1016/j.ctim.2006.03.006
   Polley MJ, 2007, SUPPORT CARE CANCER, V15, P963, DOI 10.1007/s00520-007-0283-2
   Polley MJ, 2016, INTEGR CANCER THER, V15, P435, DOI 10.1177/1534735416632060
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Selby D, 2011, J PALLIAT MED, V14, P1309, DOI 10.1089/jpm.2011.0187
   Smith CA, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2357-8
   Wardley AM, 2020, J CLIN ONCOL, V38
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
   Yun Hyeongjun, 2017, Journal of the National Cancer Institute Monographs, P29, DOI [10.1093/jncimonographs/lgx004, 10.1093/jncimonographs/lgx004]
NR 45
TC 8
Z9 9
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD APR
PY 2021
VL 20
AR 15347354211002253
DI 10.1177/15347354211002253
PG 9
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA RM7ZV
UT WOS:000639878000001
PM 33840252
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tao, S
   Wang, X
   Liao, C
   Xiong, Y
   Tang, J
   Jiang, N
   Li, Y
   Hu, X
   Shuai, R
   Wang, Y
   Wu, P
AF Tao, Siyu
   Wang, Xue
   Liao, Chenxi
   Xiong, Yan
   Tang, Jie
   Jiang, Nannan
   Li, Yuan
   Hu, Xinyue
   Shuai, Rouxian
   Wang, Yueyue
   Wu, Ping
TI The Efficacy of Moxibustion on the Serum Levels of CXCL1 and β-EP in
   Patients with Rheumatoid Arthritis
SO PAIN RESEARCH & MANAGEMENT
LA English
DT Article
ID DISEASE-ACTIVITY SCORE; PAIN; CHEMOKINES; CYTOKINES; INHIBITION;
   RECEPTORS
AB Objective. This study aims to evaluate the efficacy of moxibustion on joint swelling and pain and the levels of C-X-C motif chemokine ligand 1 (CXCL1), beta-endorphin (beta-EP) in serum of rheumatoid arthritis (RA) patients and to investigate the anti-inflammatory and analgesic mechanism of moxibustion on improving RA. Methods. Sixty-eight patients with RA were randomly and equally classified into the control and treatment groups. The control group was treated with routine drug therapy, while the treatment group received routine drug therapy and moxibustion. Both groups were treated for eight weeks. The symptoms and laboratory indicators of RA patients were compared in the two groups before and after intervention. Results. Sixty-one patients completed the study: four patients dropped out from the treatment group and three from the control group. Trial endpoints were change (Delta) in symptoms, measured by Ritchie's articular index (RAI), swollen joint count (SJC), and laboratory indicators, measured by the level of CXCL1, beta-EP, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1 beta). Delta RAI, Delta SJC, Delta CXCL1, Delta beta-EP, Delta TNF-alpha, and Delta IL-1 beta in the treatment group were superior to the control group (13.50 [14.50] versus 6.00 [13.00] in Delta RAI, 4.00 [3.00] versus 2.00 [4.00] in Delta SJC, 0.04 +/- 0.79 ng/mL versus -0.01 +/- 0.86 ng/mL in Delta CXCL1, -2.43 [5.52] pg/mg versus -0.04 [4.09] pg/mg in Delta beta-EP, 3.45 [5.90] pg/mL versus 1.55 [8.29] pg/mL in Delta TNF-alpha, and 6.15 +/- 8.65 pg/mL versus 1.28 +/- 8.51 pg/mL in Delta IL-1 beta; all P < 0.05). Conclusion. Moxibustion can improve the joint swelling and pain symptoms in patients with RA, which may be related to the fact that moxibustion can reduce the release of inflammatory factors in patients with RA and downregulate the level of CXCL1 and increase the level of beta-EP at the same time.
C1 [Tao, Siyu; Wang, Xue; Liao, Chenxi; Tang, Jie; Jiang, Nannan; Hu, Xinyue; Shuai, Rouxian; Wu, Ping] Chengdu Univ Tradit Chinese Med, Chengdu 610075, Sichuan, Peoples R China.
   [Xiong, Yan] West China Fourth Hosp, Chengdu 610075, Sichuan, Peoples R China.
   [Li, Yuan] Chengdu Univ Tradit Chinese Med Affiliated Hosp, Chengdu 610075, Sichuan, Peoples R China.
   [Wang, Yueyue] Sichuan Integrat Med Hosp, Chengdu 610075, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Wu, P (corresponding author), Chengdu Univ Tradit Chinese Med, Chengdu 610075, Sichuan, Peoples R China.
EM wuping_33@163.com
OI Liao, Chenxi/0000-0002-0572-5567; Tao, Siyu/0000-0002-5092-1743
FU National Natural Science Foundation of China [81373738]; Education
   Department of Sichuan Province [2017JY0016]
FX The authors would like to thank their colleagues from Chengdu University
   of TCM and Sichuan Hospital of Traditional Chinese Medicine, whose
   advice and expertise have provided great help for the research. This
   work was supported by the National Natural Science Foundation of China
   (81373738) and the Education Department of Sichuan Province
   (2017JY0016).
CR Aletaha D, 2010, ARTHRITIS RHEUM-US, V62, P2569, DOI 10.1002/art.27584
   Bas DB, 2016, PAIN MANAG, V6, P265, DOI 10.2217/pmt.16.4
   Brennan FM, 2008, J CLIN INVEST, V118, P3537, DOI 10.1172/JCI36389
   Cañete JD, 2009, ANN RHEUM DIS, V68, P751, DOI 10.1136/ard.2008.089284
   Chen Y, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6436420
   Chou RC, 2010, IMMUNITY, V33, P266, DOI 10.1016/j.immuni.2010.07.018
   dos Santos GG, 2020, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.03061
   Elemam NM, 2020, IMMUNOTARGETS THER, V9, P43, DOI 10.2147/ITT.S243636
   Fransen J, 2004, RHEUMATOLOGY, V43, P1252, DOI 10.1093/rheumatology/keh297
   Gerlag DM, 2008, BEST PRACT RES CL RH, V22, P311, DOI 10.1016/j.berh.2008.02.002
   Gong YY, 2019, PAIN RES MANAG, V2019, DOI 10.1155/2019/4705247
   Hale KD, 2001, NEUROIMMUNOMODULAT, V9, P34, DOI 10.1159/000049005
   He XF, 2018, EXP THER MED, V15, P4014, DOI 10.3892/etm.2018.5914
   Herenius MMJ, 2011, ANN RHEUM DIS, V70, P1160, DOI 10.1136/ard.2010.141549
   Huang CC, 2019, J PINEAL RES, V66, DOI 10.1111/jpi.12560
   Izquierdo E, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0008131
   Karlson EW, 2012, RHEUM DIS CLIN N AM, V38, P405, DOI 10.1016/j.rdc.2012.04.002
   Lai DL., 2019, CHIN ARCH TRADIT CHI, V37, P45
   Machelska H, 2003, J NEUROIMMUNOL, V141, P30, DOI 10.1016/S0165-5728(03)00213-3
   Mehrad B, 2007, THROMB HAEMOSTASIS, V97, P755, DOI 10.1160/TH07-01-0040
   MELZACK R, 1987, PAIN, V30, P191, DOI 10.1016/0304-3959(87)91074-8
   Miller MC, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102088
   Mousa SA, 2003, ADV EXP MED BIOL, V521, P77
   Qin XM, 2005, J NEUROSCI RES, V82, P51, DOI 10.1002/jnr.20612
   Ridgley LA, 2018, CURR OPIN RHEUMATOL, V30, P207, DOI 10.1097/BOR.0000000000000470
   Rittner HL, 2005, J LEUKOCYTE BIOL, V78, P1215, DOI 10.1189/jlb.0405223
   Salaffi F, 2000, RHEUMATOLOGY, V39, P90, DOI 10.1093/rheumatology/39.1.90
   Scott DL, 2010, LANCET, V376, P1094, DOI 10.1016/S0140-6736(10)60826-4
   Spetea M, 2013, CURR PHARM DESIGN, V19, P7382
   Studenic P, 2012, ARTHRITIS RHEUM-US, V64, P2814, DOI 10.1002/art.34543
   Szekanecz Z, 2001, CURR OPIN RHEUMATOL, V13, P202, DOI 10.1097/00002281-200105000-00009
   Vetter I, 2006, J PAIN, V7, P488, DOI 10.1016/j.jpain.2006.01.456
   Walker JS, 2003, ADV EXP MED BIOL, V521, P148
   Wang QQ, 2019, BMC GENOMICS, V20, DOI 10.1186/s12864-019-5510-y
   Wasserman A, 2018, AM FAM PHYSICIAN, V97, P455
   Wigerblad G, 2016, ANN RHEUM DIS, V75, P730, DOI 10.1136/annrheumdis-2015-208094
   Wu Xiao, 2018, Zhongguo Zhen Jiu, V38, P1189, DOI 10.13703/j.0255-2930.2018.11.014
   Xu Y, 2018, AM J CHINESE MED, V46, P997, DOI 10.1142/S0192415X18500520
   Yu ZY, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/7150605
   Zhang ZJ, 2013, PAIN, V154, P2185, DOI 10.1016/j.pain.2013.07.002
   Zhong YM, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/6108619
   Zhong Yu-Mei, 2020, Zhongguo Zhen Jiu, V40, P976, DOI [10.13703/j.0255-2930.20190729-0002, 10.13703/j.0255-2930.20190729-0002]
NR 42
TC 13
Z9 19
U1 2
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1203-6765
EI 1918-1523
J9 PAIN RES MANAG
JI Pain Res. Manag.
PD OCT 13
PY 2021
VL 2021
AR 7466313
DI 10.1155/2021/7466313
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5Z2DP
UT WOS:000879787500001
PM 34691317
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Chen, Y
   Li, LQ
   Wang, MH
   Li, WQ
   Zhang, Q
   Zhang, HF
   Ge, YL
AF Chen, Yi
   Li, Li Q.
   Wang, Meng H.
   Li, Wen Q.
   Zhang, Qian
   Zhang, Hai F.
   Ge, Yan L.
TI Elevated D-Dimer Combined with Persistent Acupuncture-like Chest Pain in
   An Elderly Patient Misdiagnosed as Pulmonary Embolism Finally Proved as
   Lung Hamartoma with Secondary Lung Infection by Bronchoscopy Biopsy: a
   Case Report and Literature Review
SO CLINICAL LABORATORY
LA English
DT Review
DE pulmonary embolism; D-dimer; pulmonary hamartoma; bronchoscopy;
   pathology; treatment
ID ENDOBRONCHIAL HAMARTOMA; DIAGNOSIS
AB Background: Pulmonary hamartoma is one of the most common benign tumors of the lung, the symptoms are often atypical, so its diagnosis is not so easy. We presented an elderly man with elevated D-dimer combined persistent acupuncture-like chest pain misdiagnosed as pulmonary embolism finally proved as lung hamartoma with secondary lung infection by bronchoscopy biopsy.
   Methods: Appropriate laboratory tests were carried out. The chest computed tomography (CT) scan and bronchoscopy were performed for diagnosis.
   Results: Laboratory tests showed D-dimer was 2,615.88 ng/mL, the chest CT scan showed the right lung portal occupying lesions accompanied by obstructive changes in the middle of the right lung and mediastinal lymphadenopathy with partial calcification. Bronchoscopy showed the new spherical neoplasm in the middle of the right lung completely blocked the opening of the bronchus, the surface of the neoplasm was smooth and blood vessels were abundant, pathological result was lung hamartoma.
   Conclusions: Elevated D-dimer is not a specific index of pulmonary embolism. When a patient's D-dimer rise combined with severe chest pain, the physician should be wary of pulmonary embolism, myocardial infarction, aortic dissection, and other emergencies, and should also take into account serious infections, tumors, and other diseases. Diagnosis needs further related examination. Chest CT scan has guidance function, and when the chest CT scan suggests the occupying lesion, the pathology examination is the key to identify the benign tumor.
C1 [Chen, Yi; Li, Li Q.; Li, Wen Q.; Zhang, Qian; Zhang, Hai F.; Ge, Yan L.] North China Univ Sci & Technol, Affiliated Hosp, Dept Resp Med, Jianshe Rd 73, Tangshan 063000, Hebei, Peoples R China.
   [Wang, Meng H.] North China Univ Sci & Technol, Affiliated Hosp, Dept Hosp Informat Management, Tangshan, Hebei, Peoples R China.
C3 North China University of Science & Technology; North China University
   of Science & Technology
RP Ge, YL (corresponding author), North China Univ Sci & Technol, Affiliated Hosp, Dept Resp Med, Jianshe Rd 73, Tangshan 063000, Hebei, Peoples R China.
EM geyanlei1983@qq.com
FU Hebei Province Science Development Program [20180768]
FX This work was supported by the Hebei Province Science Development
   Program [20180768].
CR Ahmed S, 2017, RESPIR MED CASE REP, V22, P224, DOI 10.1016/j.rmcr.2017.08.019
   Aktas Z, 2018, TUBERK TORAK, V66, P312, DOI 10.5578/tt.67434
   Bhargavan M, 2010, AM J ROENTGENOL, V194, P1018, DOI 10.2214/AJR.09.3215
   Boda Zoltan, 2002, Orvosi Hetilap, V143, P2717
   Cosío BG, 2002, CHEST, V122, P202, DOI 10.1378/chest.122.1.202
   Cosmi Benilde, 2003, Semin Vasc Med, V3, P303
   Dimitrakakis G, 2014, J BUON, V19, P60
   Doherty S, 2017, AUST FAM PHYSICIAN, V46, P816
   Jiang L, 2018, ONCOL LETT, V16, P660, DOI 10.3892/ol.2018.8660
   Kline JA, 2002, ANN EMERG MED, V39, P144, DOI 10.1067/mem.2002.121398
   Liu C, 2017, THER ADV RESPIR DIS, V11, P435, DOI 10.1177/1753465817736745
   Lucassen W, 2011, ANN INTERN MED, V155, P448, DOI 10.7326/0003-4819-155-7-201110040-00007
   Matsuda Eisuke, 2010, Kyobu Geka, V63, P875
   Miranda-Bacallado J, 2019, J MED CASE REP, V13, DOI 10.1186/s13256-019-1994-y
   Miyaoka Masashi, 2018, Tokai J Exp Clin Med, V43, P1
   Nazerian P, 2017, ACAD EMERG MED, V24, P270, DOI 10.1111/acem.13130
   Oshima Yutaka, 2018, Kyobu Geka, V71, P142
   Uhlén N, 2016, CLIN NUCL MED, V41, P263, DOI 10.1097/RLU.0000000000001114
   Weiss CR, 2006, ACAD RADIOL, V13, P434, DOI 10.1016/j.acra.2006.01.002
   Wu JI, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37443-4
NR 20
TC 1
Z9 1
U1 0
U2 6
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2019
VL 65
IS 9
BP 1763
EP 1766
DI 10.7754/Clin.Lab.2019.190306
PG 4
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA IY4TZ
UT WOS:000486387200025
PM 31532091
DA 2026-01-16
ER

PT J
AU Liou, KT
   Garland, SN
   Meghani, SH
   Kaye, NM
   Thompson, E
   Li, QS
   Mao, JJ
AF Liou, Kevin T.
   Garland, Sheila N.
   Meghani, Salimah H.
   Kaye, Nadia M.
   Thompson, Embree
   Li, Q. Susan
   Mao, Jun J.
TI Racial differences in treatment adherence and response to acupuncture
   and cognitive behavioral therapy for insomnia among Black and White
   cancer survivors
SO CANCER MEDICINE
LA English
DT Article
DE acupuncture; cancer survivorship; cognitive behavioral therapy;
   insomnia; oncology; racial disparities; sleep health
ID SHORT-SLEEP DURATION; SEVERITY INDEX; HEALTH; PAIN; VALIDATION;
   OUTCOMES; UPDATE; ASSOCIATION; DISPARITIES; PHENOTYPE
AB Background: Racial disparities in sleep are well-documented. However, evidence-based options for addressing these disparities are lacking in cancer populations. To inform future research on sleep interventions, this study aims to understand racial differences in treatment responses to acupuncture and cognitive behavioral therapy for insomnia (CBT-I) among Black and White cancer survivors. Methods: We conducted a secondary analysis of a comparative effectiveness trial evaluating acupuncture versus CBT-I for insomnia in cancer survivors. We compared insomnia severity, sleep characteristics, and co-morbid symptoms, as well as treatment attitudes, adherence, and responses among Black and White participants. Results: Among 156 cancer survivors (28% Black), Black survivors reported poorer sleep quality, longer sleep onset latency, and higher pain at baseline, compared to White survivors (all p < 0.05). Black survivors demonstrated lower adherence to CBT-I than White survivors (61.5% vs. 88.5%, p = 0.006), but their treatment response to CBT-I was similar to white survivors. Black survivors had similar adherence to acupuncture as white survivors (82.3% vs. 93.4%, p = 0.16), but they had greater reduction in insomnia severity with acupuncture (-3.0 points, 95% CI -5.4 to 0.4, p = 0.02). Conclusion: This study identified racial differences in sleep characteristics, as well as treatment adherence and responses to CBT-I and acupuncture. To address racial disparities in sleep health, future research should focus on improving CBT-I adherence and confirming the effectiveness of acupuncture in Black cancer survivors.
C1 [Liou, Kevin T.; Li, Q. Susan; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, New York, NY USA.
   [Garland, Sheila N.] Mem Univ Newfoundland, Dept Psychol & Oncol, St John, NF, Canada.
   [Meghani, Salimah H.] Univ Penn, Sch Nursing, Dept Biobehav Hlth Sci, Philadelphia, PA USA.
   [Kaye, Nadia M.] Stuyvesant High Sch, New York, NY USA.
   [Thompson, Embree] Weill Cornell Med Coll, New York, NY USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial University
   Newfoundland; University of Pennsylvania; Cornell University; Weill
   Cornell Medicine
RP Liou, KT (corresponding author), Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, Dept Med, Integrat Med Serv, 321 East 61st St, New York, NY 10065 USA.
EM liouk@mskcc.org
RI ; Garland, Sheila/AGL-7759-2022
OI Thompson, Embree/0000-0003-0766-4726; Garland,
   Sheila/0000-0002-6119-318X; Mao, Jun/0000-0001-9229-0380; Liou,
   Kevin/0000-0002-2438-9749
FU National Cancer Institute
FX National Institute of Nursing Research, Grant/Award Number: R01NR017853;
   Patient-Centered Outcomes Research Institute, Grant/Award Number:
   CER-1403-14292; National Cancer Institute, Grant/Award Number:
   K08CA266927-01A1, P30 CA008748, R01CA240417, R01CA270483 and
   U01CA286811<br /><br />Research reported in this paper was funded in
   part by a Patient- Centered Outcomes Research Institute (PCORI) Award
   (CER-1403-14292). This manuscript is also supported in part by a grant
   from the National Institutes of Health/National Cancer Institute Cancer
   Center (P30 CA008748) and the Translational Research and Integrative
   Medicine Fund at Memorial Sloan Kettering Cancer Center. Dr. Liou is
   supported in part by the National Cancer Institute (1K08CA266927- 01A1).
   Dr. Meghani is supported in part by the National Cancer Institute
   (R01CA270483; U01CA286811) and by the National Institute of Nursing
   Research (R01NR017853). Dr. Mao is supported in part by the National
   Cancer Institute (R01CA240417). The statements presented in this article
   are solely the responsibility of the authors and do not necessarily
   represent the views of the Patient-Centered Outcomes Research Institute
   (PCORI), its Board of Governors, or its Methodology Committee.r No
   Statement Availabler No Statement Available
CR Ahn S, 2021, SLEEP MED, V81, P169, DOI 10.1016/j.sleep.2021.02.027
   Alcántara C, 2021, SLEEP MED REV, V56, DOI 10.1016/j.smrv.2021.101455
   Anderson KO, 2004, J CLIN ONCOL, V22, P4918, DOI 10.1200/JCO.2004.06.115
   [Anonymous], 2000, Diagnostic and statistical manual of mental disorders: DSM-5, V4th, DOI [DOI 10.1176/APPI.BOOKS.9780890425596, 10.1176/appi.books.9780890425596]
   Bastien CH, 2001, SLEEP MED, V2, P297, DOI 10.1016/S1389-9457(00)00065-4
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1002/smll.202408771
   Candon M, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2021.42509
   Carney CE, 2012, SLEEP, V35, P287, DOI 10.5665/sleep.1642
   Choi TY, 2017, INTEGR CANCER THER, V16, P135, DOI 10.1177/1534735416664172
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Cleeland CS, 1997, ANN INTERN MED, V127, P813, DOI 10.7326/0003-4819-127-9-199711010-00006
   Collins KP, 2017, SLEEP MED, V32, P208, DOI 10.1016/j.sleep.2016.06.041
   Dasari SS, 2022, CANCERS, V14, DOI 10.3390/cancers14205116
   Fernandez-Mendoza J, 2017, CURR OPIN PSYCHIATR, V30, P56, DOI 10.1097/YCO.0000000000000292
   Finan PH, 2013, J PAIN, V14, P1539, DOI 10.1016/j.jpain.2013.08.007
   Fisch MJ, 2012, J CLIN ONCOL, V30, P1980, DOI 10.1200/JCO.2011.39.2381
   Fuller-Rowell TE, 2016, SLEEP MED, V27-28, P1, DOI 10.1016/j.sleep.2016.10.008
   Gapstur SM, 2014, AM J PREV MED, V46, pS26, DOI 10.1016/j.amepre.2013.10.033
   Garland SN, 2019, JNCI-J NATL CANCER I, V111, P1323, DOI 10.1093/jnci/djz050
   Garland SN, 2016, CONTEMP CLIN TRIALS, V47, P349, DOI 10.1016/j.cct.2016.02.010
   Gonzalez BD, 2018, SUPPORT CARE CANCER, V26, P4049, DOI 10.1007/s00520-018-4272-4
   Grandner MA, 2017, SLEEP MED CLIN, V12, P1, DOI 10.1016/j.jsmc.2016.10.012
   Gupta A, 2022, J CLIN ONCOL, V40, P1611, DOI 10.1200/JCO.21.02810
   Haack M, 2020, NEUROPSYCHOPHARMACOL, V45, P205, DOI 10.1038/s41386-019-0439-z
   Haus EL, 2013, SLEEP MED REV, V17, P273, DOI 10.1016/j.smrv.2012.08.003
   Hays RD, 2009, QUAL LIFE RES, V18, P873, DOI 10.1007/s11136-009-9496-9
   Hooten WM, 2012, PAIN MED, V13, P1499, DOI 10.1111/j.1526-4637.2012.01489.x
   Johnson JA, 2016, SLEEP MED REV, V27, P20, DOI 10.1016/j.smrv.2015.07.001
   Kim B, 2023, AM J EPIDEMIOL, V192, P736, DOI 10.1093/aje/kwad016
   Kim B, 2022, SLEEP, V45, DOI 10.1093/sleep/zsac087
   Koffel E, 2018, J GEN INTERN MED, V33, P955, DOI 10.1007/s11606-018-4390-1
   Laposky AD, 2016, SLEEP MED, V18, P3, DOI 10.1016/j.sleep.2015.01.007
   Lu CT, 2020, SLEEP MED, V73, P217, DOI 10.1016/j.sleep.2020.05.005
   MacLeod Jodi, 2017, Journal of the National Cancer Institute Monographs, P46, DOI [10.1093/jncimonographs/lgx008, 10.1093/jncimonographs/lgx008]
   Mao JJ, 2010, PRIMARY CARE, V37, P105, DOI 10.1016/j.pop.2009.09.010
   Petrov ME, 2016, SLEEP MED, V18, P74, DOI 10.1016/j.sleep.2015.01.011
   Savard J, 2011, J CLIN ONCOL, V29, P3580, DOI 10.1200/JCO.2010.33.2247
   Savard MH, 2005, PSYCHO-ONCOLOGY, V14, P429, DOI 10.1002/pon.860
   Sellick SM, 2007, PSYCHO-ONCOL, V16, P534, DOI 10.1002/pon.1085
   Sidani S, 2009, RES NURS HEALTH, V32, P419, DOI 10.1002/nur.20329
   Steel JL, 2018, PSYCHOSOM MED, V80, P483, DOI 10.1097/PSY.0000000000000579
   Stein KD, 2004, J PAIN SYMPTOM MANAG, V27, P14, DOI 10.1016/j.jpainsymman.2003.06.003
   Tao FR, 2021, SLEEP MED, V81, P401, DOI 10.1016/j.sleep.2021.03.015
   Trauer JM, 2015, ANN INTERN MED, V163, P191, DOI 10.7326/M14-2841
   Troxel WM, 2020, J URBAN HEALTH, V97, P230, DOI 10.1007/s11524-019-00418-5
   Vgontzas AN, 2013, SLEEP MED REV, V17, P241, DOI 10.1016/j.smrv.2012.09.005
   Wingo BC, 2014, OBES REV, V15, P46, DOI 10.1111/obr.12212
   Yang MX, 2023, CANCER-AM CANCER SOC, V129, P2084, DOI 10.1002/cncr.34766
   Yang MX, 2021, NPJ BREAST CANCER, V7, DOI 10.1038/s41523-021-00355-0
   Zhou ES, 2024, TRANSL BEHAV MED, V14, P117, DOI 10.1093/tbm/ibad056
   Zhou ES, 2022, JAMA PSYCHIAT, V79, P538, DOI 10.1001/jamapsychiatry.2022.0653
NR 51
TC 2
Z9 2
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2045-7634
J9 CANCER MED-US
JI Cancer Med.
PD AUG 19
PY 2024
VL 13
IS 16
AR e7344
DI 10.1002/cam4.7344
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA D1L5I
UT WOS:001293871500001
PM 39161103
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Maurer, J
   Ambrosini, F
   Chen, YL
   Schroeder, S
AF Maurer, Jean
   Ambrosini, Francesca
   Chen, Yuelai
   Schroeder, Sven
TI Acupuncture: a strategy for pain management among patients with prostate
   cancer - authors' reply
SO BJU INTERNATIONAL
LA English
DT Letter
C1 [Maurer, Jean] Univ Med Ctr Hamburg Eppendorf, Martini Klin Prostate Canc Ctr, Dept Urol, Hamburg, Germany.
   [Schroeder, Sven] Univ Med Ctr Hamburg Eppendorf, HanseMerkur Ctr Tradit Chinese Med, W20,Martinistr 64, D-20251 Hamburg, Germany.
   [Ambrosini, Francesca] IRCCS Osped Policlin San Martino, Genoa, Italy.
   [Chen, Yuelai] Shanghai Univ TCM, Longhua Hosp, Shanghai, Peoples R China.
   Univ Med Ctr Hamburg Eppendorf, HanseMerkur Ctr Tradit Chinese Med, W20,Martinistr 64, D-22351 Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Genoa; IRCCS AOU San Martino IST; Shanghai University of
   Traditional Chinese Medicine; University of Hamburg; University Medical
   Center Hamburg-Eppendorf
RP Schroeder, S (corresponding author), Univ Med Ctr Hamburg Eppendorf, HanseMerkur Ctr Tradit Chinese Med, W20,Martinistr 64, D-20251 Hamburg, Germany.
EM schroeder@tcm-am-uke.de
RI ; Ambrosini, Francesca/ABD-8954-2021
OI Schroeder, Sven/0000-0002-8798-9602; 
CR Hauck M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13633-4
   Miyazaki S, 2009, CLIN J PAIN, V25, P438, DOI 10.1097/AJP.0b013e318193a6e1
   Schröder S, 2017, PAIN MED, V18, P2235, DOI 10.1093/pm/pnx052
NR 3
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-4096
EI 1464-410X
J9 BJU INT
JI BJU Int.
PD OCT
PY 2024
VL 134
IS 4
BP 665
EP 666
DI 10.1111/bju.16468
EA JUL 2024
PG 2
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA L0Q6L
UT WOS:001269216900001
PM 39014978
DA 2026-01-16
ER

PT J
AU Giambrone, G
   Catone, G
   Marino, G
   Sfacteria, A
   Miloro, R
   Vullo, C
AF Giambrone, Giada
   Catone, Giuseppe
   Marino, Gabriele
   Sfacteria, Alessandra
   Miloro, Renato
   Vullo, Cecilia
TI Perioperative Pain Management for Mastectomy in Dogs: A Narrative Review
SO ANIMALS
LA English
DT Review
DE mastectomy; pain management; dog
ID ABDOMINIS PLANE BLOCK; POSTOPERATIVE PAIN; LOCAL-ANESTHESIA;
   MAMMARY-TUMORS; TUMESCENT TECHNIQUE; ANALGESIA; LIDOCAINE; TRAMADOL;
   BITCHES; METHADONE
AB Mammary tumours are the most common neoplasia in adult female dogs. Mastectomy leads to moderate to severe pain. Effective pain management is crucial in veterinary medicine. This review outlines analgesic techniques for managing perioperative pain in dogs undergoing mastectomy. A literature search on dog mastectomy analgesia was conducted from January 2001 to January 2025. Pre-emptive meloxicam reduces postoperative cardiovascular changes without affecting renal function. When combined with gabapentin, it lowers the need for rescue analgesic opioids, similar to robenacoxib. With regard to tramadol, it offers contrasting analgesia in the studies considered when used alone, while its effect appears enhanced when used in combination with meloxicam/dipyrone. However, methadone provides superior pain control, especially when given preoperatively or intraoperatively. The combination of ketamine, lidocaine, and maropitant enhances pain management, while fentanyl, alone or with lidocaine and ketamine, is effective for intraoperative pain control. Local infiltration with lidocaine/bupivacaine provides effective pain control, and devices like Comfont-in (R) or WSC facilitate this process. Tumescent anaesthesia using lidocaine/ropivacaine allows for extensive infiltration of the mammary gland. Epidural analgesia, paravertebral blocks, and TAP blocks are beneficial in multimodal protocols. Transdermal patches containing fentanyl/buprenorphine offer prolonged analgesia, while electroacupuncture can help reduce the need for rescue analgesics. Multimodal analgesic protocols are crucial for effective pain management in dog mastectomy surgeries, minimising the need for rescue opioids.
C1 [Giambrone, Giada; Catone, Giuseppe; Marino, Gabriele; Sfacteria, Alessandra; Miloro, Renato] Univ Messina, Dept Vet Sci, Via G Palatucci, I-98168 Messina, Italy.
   [Vullo, Cecilia] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale Ferdinando Stagno Alcontres 31, I-98166 Messina, Italy.
C3 University of Messina; University of Messina
RP Giambrone, G (corresponding author), Univ Messina, Dept Vet Sci, Via G Palatucci, I-98168 Messina, Italy.
EM ggiambrone97@gmail.com; giuseppe.catone@unime.it;
   gabriele.marino@unime.it; alessandra.sfacteria@unime.it;
   renato.miloro@gmail.com; cecilia.vullo@unime.it
RI ; SFACTERIA, Alessana/AAK-1839-2020; Giambrone, Giada/JEP-5031-2023
OI MARINO, Gabriele/0000-0001-6519-406X; SFACTERIA,
   Alessana/0000-0003-3671-3750; Giambrone, Giada/0000-0001-5484-6296;
   Miloro, Renato/0000-0003-3123-8815
CR Abdallah FW, 2012, REGION ANESTH PAIN M, V37, P193, DOI 10.1097/AAP.0b013e3182429531
   Abelson AL, 2009, VET ANAESTH ANALG, V36, P597, DOI 10.1111/j.1467-2995.2009.00487.x
   Abimussi CJX, 2014, VET ANAESTH ANALG, V41, P516, DOI 10.1111/vaa.12178
   de la Torre PA, 2014, AESTHET SURG J, V34, P198, DOI 10.1177/1090820X13515902
   Allen C, 2004, NOUS, V38, P617, DOI 10.1111/j.0029-4624.2004.00486.x
   [Anonymous], 2005, Vade-Mecum dAnesthesie des Carnivores Domestiques
   [Anonymous], 2022, AAHA Pain Management Guidelines for Dogs and Cats
   Antonucci F, 2008, J NEUROSCI, V28, P3689, DOI 10.1523/JNEUROSCI.0375-08.2008
   Bacarin CD, 2022, J ACUPUNCT MERIDIAN, V15, P121, DOI 10.51507/j.jams.2022.15.2.121
   Bach-Rojecky L, 2009, PHARMACOL BIOCHEM BE, V94, P234, DOI 10.1016/j.pbb.2009.08.012
   Basbaum AI, 2009, CELL, V139, P267, DOI 10.1016/j.cell.2009.09.028
   Becerra JRH, 2022, VET ANAESTH ANALG, V49, P126, DOI 10.1016/j.vaa.2021.10.001
   Beier SL, 2015, SEMIN-CIENC AGRAR, V36, P3139, DOI 10.5433/1679-0359.2015v36n5p3139
   Bergh A, 2021, ANIMALS-BASEL, V11, DOI 10.3390/ani11123356
   Berry SH, 2015, VET CLIN N AM-SMALL, V45, P1013, DOI 10.1016/j.cvsm.2015.04.007
   Boeer B, 2023, ARCH GYNECOL OBSTET, V308, P935, DOI 10.1007/s00404-023-06938-5
   Camu Frederic, 2002, Best Pract Res Clin Anaesthesiol, V16, P475, DOI 10.1053/bean.2002.0262
   Caramalac SM, 2022, AN ACAD BRAS CIENC, V94, DOI 10.1590/0001-3765202220210082
   Cardozo HG, 2024, VET ANAESTH ANALG, V51, P381, DOI 10.1016/j.vaa.2024.04.006
   Carpenter RE, 2004, VET ANAESTH ANALG, V31, P46, DOI 10.1111/j.1467-2995.2004.00137.x
   Chrisman C., 2007, Xies Veterinary Acupuncture, P129, DOI [10.1002/9780470344569.ch5, DOI 10.1002/9780470344569.CH5]
   Cicirelli V, 2022, VET MED SCI, V8, P469, DOI 10.1002/vms3.691
   Costa GL, 2024, ANIMALS-BASEL, V14, DOI 10.3390/ani14131902
   Crociolli GC, 2015, J VET MED SCI, V77, P1011, DOI 10.1292/jvms.14-0602
   Cui ML, 2004, PAIN, V107, P125, DOI 10.1016/j.pain.2003.10.008
   de Moura RS, 2022, BMC VET RES, V18, DOI 10.1186/s12917-022-03244-1
   Della Rocca G, 2018, VET ITAL, V54, P251, DOI 10.12834/VetIt.699.3421.3
   Dewey CW, 2021, OPEN VET J, V11, P203, DOI 10.5455/OVJ.2021.v11.i2.3
   Donati PA, 2021, VET ANAESTH ANALG, V48, P283, DOI 10.1016/j.vaa.2021.01.003
   Engwerda EEC, 2011, DIABETES CARE, V34, P1804, DOI 10.2337/dc11-0182
   Enomoto H, 2022, J VET PHARMACOL THER, V45, P358, DOI 10.1111/jvp.13056
   Fernandez-Parra R, 2017, VET ANAESTH ANALG, V44, P356, DOI 10.1016/j.vaa.2016.03.010
   Firth AM, 1999, J AM VET MED ASSOC, V214, P651
   Friton G, 2017, J VET INTERN MED, V31, P832, DOI 10.1111/jvim.14698
   Gach K, 2011, N-S ARCH PHARMACOL, V384, P221, DOI 10.1007/s00210-011-0672-4
   Gakiya HH, 2011, ACTA CIR BRAS, V26, P346, DOI 10.1590/S0102-86502011000500004
   Galosi M, 2022, ANIMALS-BASEL, V12, DOI 10.3390/ani12243468
   GILBERTSON SR, 1983, VET PATHOL, V20, P127, DOI 10.1177/030098588302000201
   Groeben Harald, 2006, J Anesth, V20, P290, DOI 10.1007/s00540-006-0425-6
   Credie LDGA, 2013, BMC VET RES, V9, DOI 10.1186/1746-6148-9-178
   Gupta K, 2002, CANCER RES, V62, P4491
   Hill R, 2000, TRENDS PHARMACOL SCI, V21, P244, DOI 10.1016/S0165-6147(00)01502-9
   Horta RS, 2015, ACTA VET SCAND, V57, DOI 10.1186/s13028-015-0121-3
   Interlandi C, 2022, ANIMALS-BASEL, V12, DOI 10.3390/ani12223134
   Karmakar MK, 2001, ANESTHESIOLOGY, V95, P771, DOI 10.1097/00000542-200109000-00033
   Kinobe RT, 2020, VET J, V259-26, DOI 10.1016/j.tvjl.2020.105471
   Klein JA, 1999, DERMATOL CLIN, V17, P751, DOI 10.1016/S0733-8635(05)70124-8
   KLEIN JA, 1993, PLAST RECONSTR SURG, V92, P1085, DOI 10.1097/00006534-199311000-00014
   Kong VKF, 2007, BRIT J ANAESTH, V99, P775, DOI 10.1093/bja/aem316
   Lehnhardt Marcus, 2008, Plast Reconstr Surg, V121, p396e, DOI 10.1097/PRS.0b013e318170817a
   Lemke KA, 2010, TOP COMPANION ANIM M, V25, P70, DOI 10.1053/j.tcam.2009.12.003
   Marquesa EJ, 2023, TOP COMPANION ANIM M, V52, DOI 10.1016/j.tcam.2022.100759
   Marquez M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140734
   Martins TL, 2010, AM J VET RES, V71, P1019, DOI 10.2460/ajvr.71.9.1019
   Moe L, 2001, J REP FER S, P439
   Moiniche S, 1998, BRIT J ANAESTH, V81, P377, DOI 10.1093/bja/81.3.377
   Monteiro BP, 2023, J SMALL ANIM PRACT, V64, P177, DOI 10.1111/jsap.13566
   Nakagawa K, 2007, J VET MED SCI, V69, P939, DOI 10.1292/jvms.69.939
   Novosad CA, 2003, CLIN TECH SMALL AN P, V18, P107, DOI 10.1053/svms.2003.36625
   Ochroch EA, 2003, DRUGS, V63, P2709, DOI 10.2165/00003495-200363240-00002
   Oderda G, 2012, PHARMACOTHERAPY, V32, p6S, DOI 10.1002/j.1875-9114.2012.01177.x
   Ostad A, 1996, DERMATOL SURG, V22, P921, DOI 10.1111/j.1524-4725.1996.tb00634.x
   Pascoe PJ, 2000, VET CLIN N AM-SMALL, V30, P757, DOI 10.1016/S0195-5616(08)70005-6
   Pinheiro AV, 2023, ANIMALS-BASEL, V13, DOI 10.3390/ani13213392
   Polton G, 2009, IRISH VET J, V62, P50
   Portela DA, 2014, VET ANAESTH ANALG, V41, P319, DOI 10.1111/vaa.12122
   Rocha FD, 2022, ACTA SCI VET, V50, DOI 10.22456/1679-9216.120564
   Rocha FD, 2020, ACTA SCI VET, V48, DOI 10.22456/1679-9216.102649
   Rutherford KMD, 2002, ANIM WELFARE, V11, P31
   Salas Y, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127381
   Sanches Mariana Cardoso, 2020, Ciênc. anim. bras., V21, pe, DOI [10.1590/1809-6891v21e-53552, 10.1590/1809-6891v21e-53552]
   Santamaria LB, 2010, SURG ONCOL, V19, P63, DOI 10.1016/j.suronc.2009.03.007
   Santoro F, 2022, JAVMA-J AM VET MED A, V260, pS53, DOI 10.2460/javma.21.04.0188
   Sarrau S, 2007, J SMALL ANIM PRACT, V48, P670, DOI 10.1111/j.1748-5827.2007.00362.x
   Shavit Y, 2004, NEUROIMMUNOMODULAT, V11, P255, DOI 10.1159/000078444
   Shimizu N., 2007, Dtsch. Z. Akupunkt, V50, P6, DOI [10.1078/0415-6412-00258, DOI 10.1078/0415-6412-00258]
   Shipton EA, 2000, ANAESTH INTENS CARE, V28, P363, DOI 10.1177/0310057X0002800403
   Sleeckx N, 2011, REPROD DOMEST ANIM, V46, P1112, DOI 10.1111/j.1439-0531.2011.01816.x
   Slingsby LS, 2000, RES VET SCI, V69, P147, DOI 10.1053/rvsc.2000.0406
   Smith LJ, 2002, PAIN, V97, P267, DOI 10.1016/S0304-3959(02)00028-3
   Soares PCLR, 2021, VET MED INT, V2021, DOI 10.1155/2021/4747301
   Sorenmo K, 2003, VET CLIN N AM-SMALL, V33, P573, DOI 10.1016/S0195-5616(03)00020-2
   Sorenmo KU., 2013, Withrow MacEwen's Small Animal Clinical Oncology, V5th, P538, DOI [10.1016/B978-1-4377-2362-5.00027-X, DOI 10.1016/B978-1-4377-2362-5.00027-X, 10.1016/b978-1-4377-2362-5.00027-x]
   Steagall PVM, 2017, FRONT VET SCI, V4, DOI 10.3389/fvets.2017.00068
   Steagall PV, 2020, BMC VET RES, V16, DOI 10.1186/s12917-020-02364-w
   Suárez-Redondo M, 2024, VET RES COMMUN, V48, P2707, DOI 10.1007/s11259-024-10377-1
   Sztark F, 1998, ANESTHESIOLOGY, V88, P1340, DOI 10.1097/00000542-199805000-00026
   Tan C, 2004, AUST VET J, V82, P65, DOI 10.1111/j.1751-0813.2004.tb14646.x
   Tayari H, 2022, ANIMALS-BASEL, V12, DOI 10.3390/ani12050587
   Taylor R, 2013, PAIN PRACT, V13, P332, DOI 10.1111/j.1533-2500.2012.00595.x
   Teixeira LG, 2018, PESQUI VET BRASIL, V38, P315, DOI 10.1590/1678-5150-PVB-5007
   Teixeira RCR, 2013, VET ANAESTH ANALG, V40, P641, DOI 10.1111/vaa.12080
   Thomas J, 2001, AESTHET PLAST SURG, V25, P343, DOI 10.1007/s002660010146
   Uscategui RAR, 2017, PAK VET J, V37, P345
   Uscategui RAR, 2017, REV COLOMB CIENC PEC, V30, P39, DOI 10.17533/udea.rccp.v30n1a05
   Vettorato E, 2010, VET J, V183, P310, DOI 10.1016/j.tvjl.2008.11.002
   Vilhegas S, 2015, VET REC, V177, DOI 10.1136/vr.102993
   Vullo C, 2021, ANIMALS-BASEL, V11, DOI 10.3390/ani11051280
   YOUNG LE, 1990, J SMALL ANIM PRACT, V31, P554, DOI 10.1111/j.1748-5827.1990.tb00685.x
NR 99
TC 0
Z9 0
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 2076-2615
J9 ANIMALS-BASEL
JI Animals
PD APR 25
PY 2025
VL 15
IS 9
AR 1214
DI 10.3390/ani15091214
PG 21
WC Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences; Zoology
GA 2MH6G
UT WOS:001486044500001
PM 40362030
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Gonzalo-Marin, J
   Vila, JJ
   Perez-Miranda, M
AF Gonzalo-Marin, Juana
   Jose Vila, Juan
   Perez-Miranda, Manuel
TI Role of endoscopic ultrasound in the diagnosis of pancreatic cancer
SO WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
LA English
DT Article
DE Endosonography; Pancreatic neoplasms; Endoscopy; Diagnosis; Neoplasm
   Staging; Therapeutics
AB Endoscopic ultrasonography (EUS) with or without fine needle aspiration has become the main technique for evaluating pancreatobiliary disorders and has proved to have a higher diagnostic yield than positron emission tomography, computed tomography (CT) and transabdominal ultrasound for recognising early pancreatic tumors. As a diagnostic modality for pancreatic cancer, EUS has proved rates higher than 90%, especially for lesions less than 2-3 cm in size in which it reaches a sensitivity rate of 99% vs 55% for CT. Besides, EUS has a very high negative predictive value and thus EUS can reliably exclude pancreatic cancer. The complication rate of EUS is as low as 1.1%-3.0%. New technical developments such as elastography and the use of contrast agents have recently been applied to EUS, improving its diagnostic capability. EUS has been found to be superior to the recent multidetector CT for T staging with less risk of overstaying in comparison to both CT and magnetic resonance imaging, so that patients are not being ruled out of a potentially beneficial resection. The accuracy for N staging with EUS is 64%-82%. In unresectable cancers, EUS also plays a therapeutic role by means of treating oncological pain through celiac plexus block, biliary drainage in obstructive jaundice in patients where endoscopic retrograde cholangiopancreatography is not affordable and aiding radiotherapy and chemotherapy. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 [Gonzalo-Marin, Juana] Quiron Hosp, Dept Gastroenterol, Unit Endoscopy, Marbella 29603, Spain.
   [Jose Vila, Juan] Complejo Hosp Navarra, Unit Endoscopy, Dept Gastroenterol, Pamplona 31008, Spain.
   [Perez-Miranda, Manuel] Hosp Univ Rio Hortega, Dept Gastroenterol, Dulzaina St, Valladolid 47012, Spain.
C3 Servicio Navarro de Salud - Osasunbidea; Hospital del Rio Hortega
RP Perez-Miranda, M (corresponding author), Hosp Univ Rio Hortega, Dept Gastroenterol, Dulzaina St, Valladolid 47012, Spain.
EM mperezmiranda@saludcastillayleon.es
RI Vila, Juan J/E-9123-2010
OI Vila, Juan J/0000-0003-1446-3121
CR Alsohaibani F, 2009, CAN J GASTROENTEROL, V23, P26, DOI 10.1155/2009/194351
   [Anonymous], AM SURG, DOI [10.1016/j.jaci.2012.05.050, DOI 10.1016/J.JACI.2012.05.050]
   Arabul M, 2012, HEPATO-GASTROENTEROL, V59, P1599, DOI 10.5754/hge11608
   Arcidiacono PG, 2011, COCHRANE DB SYST REV, V16
   Ardengh JC, 2007, J PANCREAS, V8, P413
   Aslanian H, 2005, AM J GASTROENTEROL, V100, P1381, DOI 10.1111/j.1572-0241.2005.41675.x
   Barthet M, 1996, ENDOSCOPY, V28, P487, DOI 10.1055/s-2007-1005528
   Becker D, 2001, GASTROINTEST ENDOSC, V53, P784, DOI 10.1067/mge.2001.115007
   Berberat P, 1999, WORLD J SURG, V23, P882, DOI 10.1007/s002689900593
   Bhutani MS, 2004, ENDOSCOPY, V36, P385, DOI 10.1055/s-2004-814320
   Bipat S, 2005, J COMPUT ASSIST TOMO, V29, P438, DOI 10.1097/01.rct.0000164513.23407.b3
   Bories E, 2007, ENDOSCOPY, V39, P287, DOI 10.1055/s-2007-966212
   Burmester E, 2003, GASTROINTEST ENDOSC, V57, P246, DOI 10.1067/mge.2003.85
   Byrne MF, 2002, GASTROENTEROLOGY, V122, P1631, DOI 10.1053/gast.2002.33576
   Canto MI, 2004, CLIN GASTROENTEROL H, V2, P606, DOI 10.1016/S1542-3565(04)00244-7
   Chang KJ, 2000, CANCER-AM CANCER SOC, V88, P1325, DOI 10.1002/(SICI)1097-0142(20000315)88:6<1325::AID-CNCR8>3.0.CO;2-T
   Chen VK, 2004, AM J GASTROENTEROL, V99, P2223, DOI 10.1111/j.1572-0241.2004.40042.x
   Chong A, 2011, GASTROINTEST ENDOSC, V74, P933, DOI 10.1016/j.gie.2010.10.020
   Collins D, 2006, ENDOSCOPY, V38, P935, DOI 10.1055/s-2006-944734
   D'Onofrio M, 2007, ABDOM IMAGING, V32, P171, DOI 10.1007/s00261-006-9010-6
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   DeWitt J, 2004, ANN INTERN MED, V141, P753, DOI 10.7326/0003-4819-141-10-200411160-00006
   Dietrich CF, 2009, ENDOSCOPIC ULTRASOUN, P196
   Dietrich CF, 2008, CLIN GASTROENTEROL H, V6, P590, DOI 10.1016/j.cgh.2008.02.030
   EISENBERG E, 1995, ANESTH ANALG, V80, P290, DOI 10.1097/00000539-199502000-00015
   Eloubeidi MA, 2003, CANCER CYTOPATHOL, V99, P285, DOI 10.1002/cncr.11643
   Eloubeidi MA, 2008, DIGEST DIS, V26, P356, DOI 10.1159/000177022
   Erickson RA, 2000, GASTROINTEST ENDOSC, V51, P184, DOI 10.1016/S0016-5107(00)70416-0
   Fritscher-Ravens A, 2002, AM J GASTROENTEROL, V97, P2768
   Frulloni L, 2010, DIGEST LIVER DIS, V42, pS381, DOI 10.1016/S1590-8658(10)60682-2
   Fukasawa M, 2012, GASTROINTEST ENDOSC, V75, P132
   Fusari M, 2010, RADIOL MED, V115, P453, DOI 10.1007/s11547-010-0490-7
   Fusaroli P, 2010, CLIN GASTROENTEROL H, V8, P629, DOI 10.1016/j.cgh.2010.04.012
   GEER RJ, 1993, AM J SURG, V165, P68, DOI 10.1016/S0002-9610(05)80406-4
   Giovannini M, 2010, GASTROEN CLIN BIOL, V34, P436, DOI 10.1016/j.gcb.2010.05.004
   Gong TT, 2012, GASTROINTEST ENDOSC, V76, P301, DOI 10.1016/j.gie.2012.02.051
   Gress F, 1997, GASTROINTEST ENDOSC, V45, P138, DOI 10.1016/S0016-5107(97)70236-0
   Gress FG, 1999, GASTROINTEST ENDOSC, V50, P786, DOI 10.1016/S0016-5107(99)70159-8
   Hakimé A, 2007, J RADIOL, V88, P11, DOI 10.1016/S0221-0363(07)89785-X
   Harewood GC, 2002, AM J GASTROENTEROL, V97, P1386, DOI 10.1016/S0002-9270(02)04133-3
   Hartwig W, 2009, BRIT J SURG, V96, P5, DOI 10.1002/bjs.6407
   Hirooka Y, 2003, J GASTROEN HEPATOL, V18, P1323, DOI 10.1046/j.1440-1746.2003.03040.x
   Hocke M, 2006, WORLD J GASTROENTERO, V12, P246, DOI 10.3748/wjg.v12.i2.246
   Howard TJ, 1997, AM J SURG, V174, P237, DOI 10.1016/S0002-9610(97)00132-3
   Hunt GC, 2002, GASTROINTEST ENDOSC, V55, P232, DOI 10.1067/mge.2002.121342
   Iglesias-Garcia J, 2012, GASTROINTEST ENDOSC, V75, P147
   Iglesias-Garcia J, 2011, AM J GASTROENTEROL, V106, P1705, DOI 10.1038/ajg.2011.119
   Iglesias-Garcia J, 2011, GASTROINTEST ENDOSC, V73, P1189, DOI 10.1016/j.gie.2011.01.053
   Iglesias-Garcia J, 2010, GASTROENTEROLOGY, V139, P1172, DOI 10.1053/j.gastro.2010.06.059
   Iglesias-Garcia J, 2009, GASTROINTEST ENDOSC, V70, P1101, DOI 10.1016/j.gie.2009.05.011
   Itoi T, 2005, ENDOSCOPY, V37, P362, DOI 10.1055/s-2004-826156
   Jacobson BC, 2005, GASTROINTEST ENDOSC, V61, P8, DOI 10.1016/S0016-5107(04)02393-4
   Jemal A, 2008, CA-CANCER J CLIN, V58, P71, DOI 10.3322/CA.2007.0010
   Kahaleh M, 2004, GASTROINTEST ENDOSC, V60, P138, DOI 10.1016/S0016-5107(04)01528-7
   Kahaleh M, 2012, GASTROINTEST ENDOSC, V75, P193
   Kala Z, 2007, EUR J RADIOL, V62, P166, DOI 10.1016/j.ejrad.2007.01.039
   Katanuma A, 2012, ENDOSCOPY, V44, pE160, DOI 10.1055/s-0031-1291716
   KAUFMAN AR, 1989, GASTROINTEST ENDOSC, V35, P214, DOI 10.1016/S0016-5107(89)72761-9
   Kinney T, 2010, SURG CLIN N AM, V90, P235, DOI 10.1016/j.suc.2009.12.003
   Klapman JB, 2005, AM J GASTROENTEROL, V100, P2658, DOI 10.1111/j.1572-0241.2005.00315.x
   Krishna NB, 2009, GASTROINTEST ENDOSC, V70, P70, DOI 10.1016/j.gie.2008.10.030
   Kulig J, 2005, SURG ENDOSC, V19, P361, DOI 10.1007/s00464-004-9056-x
   LeBlanc JK, 2004, GASTROINTEST ENDOSC, V59, P475, DOI 10.1016/S0016-5107(03)02863-3
   Magno P, 2008, GASTROINTEST ENDOSC, V67, P1147, DOI 10.1016/j.gie.2008.02.053
   Mallery S, 2004, GASTROINTEST ENDOSC, V59, P100, DOI 10.1016/S0016-5107(03)02300-9
   Manabu Matsumura, 2007, Folia Pharmacologica Japonica, V130, P413
   MANTEL N, 1959, JNCI-J NATL CANCER I, V22, P719
   Mertz HR, 2000, GASTROINTEST ENDOSC, V52, P367, DOI 10.1067/mge.2000.107727
   Michaels AJ, 2007, WORLD J GASTROENTERO, V13, P3575, DOI 10.3748/wjg.v13.i26.3575
   Millikan KW, 1999, AM SURGEON, V65, P618
   NAKAIZUMI A, 1995, DIGEST DIS SCI, V40, P696, DOI 10.1007/BF02064392
   Napoleon B, 2010, ENDOSCOPY, V42, P564, DOI 10.1055/s-0030-1255537
   Oh HC, 2011, GASTROENTEROLOGY, V140, P172, DOI 10.1053/j.gastro.2010.10.001
   Owens DJ, 2010, SURG ONCOL CLIN N AM, V19, P255, DOI 10.1016/j.soc.2009.11.009
   Ozawa Y, 2002, J ULTRAS MED, V21, P983, DOI 10.7863/jum.2002.21.9.983
   Paquin SC, 2005, GASTROINTEST ENDOSC, V61, P610, DOI 10.1016/S0016-5107(05)00082-9
   Perez-Miranda M, 2010, WORLD J GASTRO ENDOS, V2, P212, DOI 10.4253/wjge.v2.i6.212
   Puli SR, 2007, GASTROINTEST ENDOSC, V65, P788, DOI 10.1016/j.gie.2006.08.028
   Ramsay Duncan, 2004, Australas Radiol, V48, P154, DOI 10.1111/j.1440-1673.2004.01277.x
   Recaldini Chiara, 2008, Int J Med Sci, V5, P203
   Reicher S, 2011, PANCREAS, V40, P1057, DOI 10.1097/MPA.0b013e3182200201
   Rickes S, 2002, SCAND J GASTROENTERO, V37, P1313, DOI 10.1080/003655202761020605
   ROSCH T, 1991, GASTROINTEST ENDOSC, V37, P347, DOI 10.1016/S0016-5107(91)70729-3
   Rulyak SJ, 2003, GASTROINTEST ENDOSC, V57, P23, DOI 10.1067/mge.2003.28
   Saftoiu A, 2009, J CLIN ULTRASOUND, V37, P1, DOI 10.1002/jcu.20534
   Sakamoto H, 2008, ULTRASOUND MED BIOL, V34, P525, DOI 10.1016/j.ultrasmedbio.2007.09.018
   Sakamoto H, 2009, J GASTROEN HEPATOL, V24, P384, DOI 10.1111/j.1440-1746.2008.05636.x
   Sanders MK, 2010, GASTROINTEST ENDOSC, V71, P1178, DOI 10.1016/j.gie.2009.12.020
   Sandrasegaran K, 2010, AM J ROENTGENOL, V195, P42, DOI 10.2214/AJR.10.4421
   Schmulewitz N, 2003, ENDOSCOPY, V35, pS49
   Seicean A, 2010, ULTRASCHALL MED, V31, P571, DOI 10.1055/s-0029-1245833
   Seicean A, 2010, WORLD J GASTROENTERO, V16, P4253, DOI 10.3748/wjg.v16.i34.4253
   Sethi A, 2012, GASTROINTEST ENDOSC, V75, P147
   Shah JN, 2004, GASTROINTEST ENDOSC, V59, P923, DOI 10.1016/S0016-5107(04)00340-2
   Sohn TA, 2000, J GASTROINTEST SURG, V4, P567, DOI 10.1016/S1091-255X(00)80105-5
   Soriano A, 2004, AM J GASTROENTEROL, V99, P492, DOI 10.1111/j.1572-0241.2004.04087.x
   Takahashi K, 2005, GASTROINTEST ENDOSC, V61, P76, DOI 10.1016/S0016-5107(04)02224-2
   Taylor B, 2003, WORLD J SURG, V27, P1249, DOI 10.1007/s00268-003-7245-8
   Tellez-Avila FI, 2012, PANCREAS, V41, P636, DOI 10.1097/MPA.0b013e31823e3632
   Toft KG, 2006, ULTRASOUND MED BIOL, V32, P107, DOI 10.1016/j.ultrasmedbio.2005.09.008
   Varadarajulu S, 2005, GASTROINTEST ENDOSC, V62, P728, DOI 10.1016/j.gie.2005.06.051
   Varadarajulu S, 2010, SURG CLIN N AM, V90, P251, DOI 10.1016/j.suc.2010.01.002
   Vila JJ, 2012, GASTROINTEST ENDOSC, V76, P1133, DOI 10.1016/j.gie.2012.08.001
   Wallace MB, 2001, GASTROINTEST ENDOSC, V53, P294, DOI 10.1067/mge.2001.112191
   Wiersema MJ, 1996, GASTROINTEST ENDOSC, V43, P102, DOI 10.1016/S0016-5107(06)80108-2
   Wyse JM, 2011, J CLIN ONCOL, V29, P3541, DOI 10.1200/JCO.2010.32.2750
   Yan BM, 2007, AM J GASTROENTEROL, V102, P430, DOI 10.1111/j.1572-0241.2006.00967.x
   YASUDA K, 1993, ENDOSCOPY, V25, P151, DOI 10.1055/s-2007-1010274
   Yeo Theresa Pluth, 2002, Curr Probl Cancer, V26, P176, DOI 10.1067/mcn.2002.129579
NR 109
TC 58
Z9 69
U1 0
U2 8
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1948-5204
J9 WORLD J GASTRO ONCOL
JI World J. Gastrointest. Oncol.
PD SEP 15
PY 2014
VL 6
IS 9
BP 360
EP 368
DI 10.4251/wjgo.v6.i9.360
PG 9
WC Oncology; Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Gastroenterology & Hepatology
GA V9A4O
UT WOS:000422133300006
PM 25232461
OA hybrid
DA 2026-01-16
ER

PT J
AU Gao, J
   Yuan, YS
   Lu, T
   Lv, HR
   Xu, HL
AF Gao, Jie
   Yuan, Yu-Song
   Lu, Ting
   Lv, Hao-Run
   Xu, Hai-Lin
TI Synovial sarcoma in the plantar region: A case report and literature
   review
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Review
DE Imaging examination; Pathological examination; Plantar; Synovial
   sarcoma; Case report
ID SOFT-TISSUE TUMORS; CHEMOTHERAPY; METASTASIS
AB BACKGROUND
   Synovial sarcoma (SS), a rare malignant soft tissue tumor whose histological origin is still unknown, often occurs in limbs in young people and is easily misdiagnosed.
   CASE SUMMARY
   We report a 24-year-old man who sought treatment for plantar pain thought to be caused by a foot injury that occurred 4 years prior. Currently, he had been seen at another hospital for a 1-wk history of unexplained pain in the left plantar region and was treated with acupuncture, a kind of therapy of Chinese medicine, which partly relieved the pain. Because of this, the final diagnosis of biphasic SS was made after two subsequent treatments by pathological evaluation after the last operation. SS is rarely seen in the plantar area, and his history of a left plantar injury confused the original diagnosis.
   CONCLUSION
   This study shows that pathological and imaging examinations may play a vital role in the early diagnosis and treatment of SS.
C1 [Gao, Jie; Lu, Ting] Pingxiang Med Sch, Pingxiang Hlth Vocat Coll, Pingxiang 337000, Jiangxi, Peoples R China.
   [Yuan, Yu-Song; Lv, Hao-Run; Xu, Hai-Lin] Peking Univ, Dept Trauma & Orthoped, Peoples Hosp, 11 South Xizhimen St, Beijing 100044, Peoples R China.
C3 Peking University
RP Xu, HL (corresponding author), Peking Univ, Dept Trauma & Orthoped, Peoples Hosp, 11 South Xizhimen St, Beijing 100044, Peoples R China.
EM xuhailinfa@163.com
CR Alhazzani AR, 2010, UROL ANNALS, V2, P39, DOI 10.4103/0974-7796.62916
   Bakri A, 2012, AM J ROENTGENOL, V199, pW208, DOI 10.2214/AJR.11.8039
   Beck SE, 2011, INT J SURG ONCOL, V2011, DOI 10.1155/2011/184891
   BERGER LOUIS, 1938, AMER JOUR CANCER, V34, P501
   Brisse HJ, 2010, PEDIATR RADIOL, V40, P1019, DOI 10.1007/s00247-010-1592-z
   Chen Y, 2012, J SURG ONCOL, V106, P162, DOI 10.1002/jso.23061
   Deraedt K, 2006, HISTOPATHOLOGY, V48, P473, DOI 10.1111/j.1365-2559.2005.02270.x
   Deshmukh R, 2004, CLIN ORTHOP RELAT R, P155, DOI 10.1097/01.blo.0000111887.82016.b0
   Egger JF, 2002, MODERN PATHOL, V15, P998, DOI 10.1097/01.MP.0000026616.41545.FF
   Eilber FC, 2007, ANN SURG, V246, P105, DOI 10.1097/01.sla.0000262787.88639.2b
   Fedors NH, 2010, ORTHOPEDICS, V33, P861, DOI 10.3928/01477447-20101021-35
   Frank G. A., 2016, Arkhiv Patologii, V78, P32, DOI [10.17116/patol201678432-42, 10.17116/patol201678432-42]
   Haldar M, 2008, CLIN ORTHOP RELAT R, V466, P2156, DOI 10.1007/s11999-008-0340-2
   Jeganathan Reubendra, 2007, Ulster Med J, V76, P109
   Jung SC, 2007, SKELETAL RADIOL, V36, P67, DOI 10.1007/s00256-006-0185-2
   Kadapa NPB, 2014, INDIA J SURG ONCOL, V5, P75, DOI 10.1007/s13193-013-0285-0
   Kanemitsu S, 2007, DIAGN MOL PATHOL, V16, P9, DOI 10.1097/PDM.0b013e318031f02f
   Kartha SS, 2002, LARYNGOSCOPE, V112, P1979, DOI 10.1097/00005537-200211000-00013
   Le Loarer F, 2014, GENE CHROMOSOME CANC, V53, P475, DOI 10.1002/gcc.22159
   Liang CH, 2015, ONCOL LETT, V9, P661, DOI 10.3892/ol.2014.2774
   Murphey MD, 2006, RADIOGRAPHICS, V26, P1543, DOI 10.1148/rg.265065084
   Ranchère-Vince D, 2010, ARCH PEDIATRIE, V17, P717, DOI 10.1016/S0929-693X(10)70075-0
   Romeo S, 2015, CLIN SARCOMA RES, V5, DOI 10.1186/s13569-015-0021-3
   Scheer M, 2016, PEDIATR BLOOD CANCER, V63, P1198, DOI 10.1002/pbc.25973
   Scheithauer BW, 2007, NEURO-ONCOLOGY, V9, P454, DOI 10.1215/15228517-2007-029
   Shi WY, 2013, AM J CLIN ONCOL-CANC, V36, P83, DOI 10.1097/COC.0b013e31823fe450
   Tang YM, 2006, SKELETAL RADIOL, V35, P783, DOI 10.1007/s00256-005-0934-7
   Thway K, 2014, ANN DIAGN PATHOL, V18, P369, DOI 10.1016/j.anndiagpath.2014.09.002
   Vlenterie M, 2016, EUR J CANCER, V58, P62, DOI 10.1016/j.ejca.2016.02.002
   Yasui H, 2016, J CHEMOTHERAPY, V28, P417, DOI 10.1080/1120009X.2015.1133013
NR 30
TC 4
Z9 4
U1 0
U2 10
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD SEP 6
PY 2019
VL 7
IS 17
BP 2549
EP 2555
DI 10.12998/wjcc.v7.i17.2549
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IW2NB
UT WOS:000484815000015
PM 31559291
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Tsai, AWW
   D'Alessandro, E
   Brandao, S
   Guerreiro, JB
   Bassetto, RM
   Bandeira, JS
   Pai, MYB
   Höhl, A
   da Silva, AV
   Sant'Anna, FM
AF Tsai, Andre Wan Wen
   D'Alessandro, Eduardo
   Brandao, Sidney
   Guerreiro, Joao Bosco
   Bassetto, Ricardo Morad
   Bandeira, Janete Shatkoski
   Pai, Marcus Yu Bin
   Hohl, Adriano
   da Silva, Alexandre Valotta
   Sant'Anna, Fernando Mendes
TI Acupuncture in cancer care: a narrative review
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Review
ID BREAST-CANCER; SLEEP DISTURBANCES; PALLIATIVE CARE; HOT FLASHES;
   FATIGUE; SAFETY; PAIN; CHEMOTHERAPY; MANAGEMENT; INSOMNIA
C1 [Tsai, Andre Wan Wen; D'Alessandro, Eduardo; Brandao, Sidney; Guerreiro, Joao Bosco; Bassetto, Ricardo Morad; Bandeira, Janete Shatkoski; Pai, Marcus Yu Bin; Hohl, Adriano; da Silva, Alexandre Valotta; Sant'Anna, Fernando Mendes] Brazilian Coll Med Acupuncture, Sao Paulo, SP, Brazil.
   [Tsai, Andre Wan Wen; D'Alessandro, Eduardo] Univ Sao Paulo, Clin Hosp, Fac Med, Sao Paulo, SP, Brazil.
   [Brandao, Sidney] Sao Leopoldo Mand Fac Med, Sao Paulo, SP, Brazil.
   [Guerreiro, Joao Bosco] Fac Med Sao Jose do Rio Preto, Sao Jose Do Rio Preto, Brazil.
   [Bassetto, Ricardo Morad; Pai, Marcus Yu Bin] Inst Sci Chinese Med, Sao Paulo, SP, Brazil.
   [Bandeira, Janete Shatkoski] Neurofunct Acupuncture Study Grp, Porto Alegre, RS, Brazil.
   [da Silva, Alexandre Valotta] Santa Casa Braganca Paulista, Sao Paulo, SP, Brazil.
   [Sant'Anna, Fernando Mendes] Univ Fed Rio De Janeiro, Macae, RJ, Brazil.
C3 Universidade de Sao Paulo; Faculdade de Medicina de Sao Jose do Rio
   Preto (FAMERP); Universidade Federal do Rio de Janeiro
RP Sant'Anna, FM (corresponding author), Brazilian Coll Med Acupuncture, Sao Paulo, SP, Brazil.; Sant'Anna, FM (corresponding author), Univ Fed Rio De Janeiro, Macae, RJ, Brazil.
EM fmsantanna@gmail.com
RI ; Guerreiro, João/U-7209-2019; Bandeira, Janete/N-2352-2017; Mendes
   Sant'Anna, Fernando/B-3508-2015; Valotta da Silva, Alexane/A-2634-2011
OI D'Alessano, Eduardo/0000-0001-7146-8530; Tsai, Ane/0000-0003-1867-7004;
   BRANDÃO, SIDNEY/0009-0009-2780-7131; HÖHL, AIANO/0009-0002-7976-7476;
   Bandeira, Janete/0000-0002-3083-2073; Mendes Sant'Anna,
   Fernando/0000-0003-3998-8813; Valotta da Silva,
   Alexane/0000-0001-7107-0864
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Anderson KO, 2003, J PAIN SYMPTOM MANAG, V25, P307, DOI 10.1016/S0885-3924(02)00682-6
   Bao T, 2018, BREAST CANCER RES TR, V170, P77, DOI 10.1007/s10549-018-4743-9
   Birch S, 2019, INTEGR MED RES, V8, P160, DOI 10.1016/j.imr.2019.05.002
   Bonomo P, 2022, EUR ARCH OTO-RHINO-L, V279, P2083, DOI 10.1007/s00405-021-07002-1
   Cassileth BR, 2011, ACUPUNCT MED, V29, P170, DOI 10.1136/aim.2011.004069
   Chen ML, 2008, LUNG CANCER, V62, P391, DOI 10.1016/j.lungcan.2008.03.016
   Chien TJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419866910
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Choi TY, 2022, CANCERS, V14, DOI 10.3390/cancers14184419
   Choi TY, 2017, INTEGR CANCER THER, V16, P135, DOI 10.1177/1534735416664172
   [崔瑾 Cui J], 2007, [中国组织工程研究与临床康复, Journal of Clinical Rehabilitative Tissue Engineering Research], V11, P5473
   D'Alessandro EG, 2022, MED ACUPUNCT, V34, P58, DOI 10.1089/acu.2021.0073
   Dans M, 2021, J NATL COMPR CANC NE, V19, P780, DOI 10.6004/jnccn.2021.0033
   Davidson JR, 2002, SOC SCI MED, V54, P1309, DOI 10.1016/S0277-9536(01)00043-0
   Ernst E, 2001, AM J MED, V110, P481, DOI 10.1016/S0002-9343(01)00651-9
   Ezzo J, 2005, J CLIN ONCOL, V23, P7188, DOI 10.1200/JCO.2005.06.028
   Fallon M, 2018, ANN ONCOL, V29, P166, DOI 10.1093/annonc/mdy152
   Ferlay J, 2021, INT J CANCER, V149, P778, DOI 10.1002/ijc.33588
   Finnegan-John J, 2013, INTEGR CANCER THER, V12, P276, DOI 10.1177/1534735413485816
   Ge L, 2022, CHIN MED-UK, V17, DOI 10.1186/s13020-021-00558-4
   He XR, 2013, ASIAN PAC J CANCER P, V14, P3067, DOI 10.7314/APJCP.2013.14.5.3067
   Heckroth M, 2021, J CLIN GASTROENTEROL, V55, P279, DOI 10.1097/MCG.0000000000001485
   Horesh D, 2022, HEALTHCARE-BASEL, V10, DOI 10.3390/healthcare10112261
   Höxtermann MD, 2022, CANCER-AM CANCER SOC, V128, P2159, DOI 10.1002/cncr.34165
   Hughes JG, 2019, ACUPUNCT MED, V37, P223, DOI 10.1136/acupmed-2017-011592
   Iop A, 2004, ANN ONCOL, V15, P712, DOI 10.1093/annonc/mdh102
   Jeong YJ, 2015, MED ACUPUNCT, V27, P206, DOI 10.1089/acu.2014.1071
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Li HJ, 2021, J ALTERN COMPLEM MED, V27, P1084, DOI 10.1089/acm.2021.0133
   Li T, 2021, MENOPAUSE, V28, P564, DOI 10.1097/GME.0000000000001767
   Lian WL, 2014, CHIN J INTEGR MED, V20, P136, DOI 10.1007/s11655-013-1439-1
   Lin DZ, 2023, FRONT ONCOL, V13, DOI 10.3389/fonc.2023.1184228
   Liu LQ, 2008, PSYCHIAT ANN, V38, P627, DOI 10.3928/00485713-20080901-01
   Lu Mei, 2011, Zhongguo Zhong Xi Yi Jie He Za Zhi, V31, P238
   Lund KS, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-023637
   Mao JJ, 2015, J CLIN ONCOL, V33, P3615, DOI 10.1200/JCO.2015.60.9412
   Melchart D, 2004, ARCH INTERN MED, V164, P104, DOI 10.1001/archinte.164.1.104
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Ni XX, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420980825
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n160, 10.1136/bmj.n71, 10.1038/nchembio.2180, 10.1186/s40900-023-00424-7, 10.3390/jpm13020373]
   Paley CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub3
   Posadzki P, 2013, SUPPORT CARE CANCER, V21, P2067, DOI 10.1007/s00520-013-1765-z
   Santos MD, 2023, Revista Brasileira de Cancerologia, V69, DOI [10.32635/2176-9745.rbc.2023v69n1.3700, 10.32635/2176-9745.rbc.2023v69n1., DOI 10.32635/2176-9745.RBC.2023V69N1, 10.32635/2176-9745.RBC.2023v69n1.3700, DOI 10.32635/2176-9745.RBC.2023V69N1.3700]
   Savard J, 2001, J CLIN ONCOL, V19, P895, DOI 10.1200/JCO.2001.19.3.895
   Shih YW, 2021, INTEGR CANCER THER, V20, DOI 10.1177/15347354211063884
   Sturdee DW, 2008, MATURITAS, V60, P42, DOI 10.1016/j.maturitas.2008.02.006
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Tian H, 2023, FRONT ONCOL, V13, DOI 10.3389/fonc.2023.1071326
   van den Beuken-van Everdingen MHJ, 2016, J PAIN SYMPTOM MANAG, V51, P1070, DOI 10.1016/j.jpainsymman.2015.12.340
   Wang CCF, 2019, EUR J INTEGR MED, V27, P81, DOI 10.1016/j.eujim.2019.03.004
   World Health Organization, 2014, World Health Organ Tech Rep Ser, P1
   Wu XY, 2015, SCI REP-UK, V5, DOI 10.1038/srep16776
   Xi ZQ, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.921151
   Yang J, 2021, BMJ SUPPORT PALLIAT, V11, P264, DOI 10.1136/bmjspcare-2020-002638
   Yang YL, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/1618767
   Yao C, 2016, CURR ONCOL, V23, pE27, DOI 10.3747/co.23.2788
   Zeng YW, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-049318
   Zhang XW, 2022, PHYTOMEDICINE, V106, DOI 10.1016/j.phymed.2022.154430
   Zhang YZ, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.646315
   Zhong WX, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115797
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 62
TC 2
Z9 2
U1 1
U2 4
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
SN 0104-4230
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PY 2024
VL 70
SU 1
AR e2024S101
DI 10.1590/1806-9282.2024S101
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UU8O8
UT WOS:001250669900007
PM 38865521
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lyu, Z
   Tian, SX
   Bao, GA
   Huang, R
   Gong, LY
   Zhou, J
   Kong, XM
   Zhang, WP
   Ran, R
   Nie, N
   Liu, Y
   Ji, CH
   Liu, S
   Shao, XM
   Kai, GY
   Lin, XM
   Fang, JQ
   Liang, Y
AF Lyu, Zhengyi
   Tian, Shuxin
   Bao, Guanai
   Huang, Rui
   Gong, Liyan
   Zhou, Jie
   Kong, Xiangming
   Zhang, Weiping
   Ran, Ran
   Nie, Na
   Liu, Yang
   Ji, Conghua
   Liu, Shan
   Shao, Xiaomei
   Kai, Guoyin
   Lin, Xianming
   Fang, Jianqiao
   Liang, Yi
TI Transcutaneous electrical acupoint stimulation for cancer-related pain
   management in patients receiving chronic opioid therapy: a randomized
   clinical trial
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Transcutaneous electrical acupoint stimulation,; Acupuncture,;
   Cancer-related pain,; Chronic opioid therapy,; Transcutaneous electrical
   nerve stimulation
ID ONCOLOGY ACUPUNCTURE; BREAST-CANCER; QUALITY; MULTICENTER; MEDICINE;
   LIFE
AB Purpose The opioid crisis resulting from its use disorder and overdose poses additional challenges for cancer pain management. The American Society of Clinical Oncology Practice Guideline recommends acupuncture therapy for the management of adult cancer-related pain (CRP), but the effectiveness of transcutaneous electrical acupoint stimulation (TEAS) on CRP remains uncertain.Methods This 5-week prospective randomized clinical trial was conducted at 2 hospitals in China, and participants with CRP receiving chronic opioid therapy were randomized 1:1 into two groups between December 2014 and June 2018. The true TEAS group underwent 15 sessions of TEAS treatments over 3 consecutive weeks, while the control group received sham stimulation. The primary outcome was the numerical rating scale (NRS) score in the past 24h at week 3. The secondary outcomes included morphine equivalent daily dose, quality of life and adverse events.Results A total of 159 participants were included in the modified intention-to-treat population. The baseline characteristics were similar in both groups. The mean NRS scores were 0.98 points at week 3 in the true TEAS group and 1.41 points in the sham group, with the mean difference between groups of -0.43 points (P < 0.001; OR = 0.68, P < 0.05). The proportion of patients with NRS reduction more than thirty percentage at week 3 was 50.00% in the true TEAS group and 35.44% in the sham group (RD = 0.15, P > 0.05; RR = 1.41, P > 0.05). No significant difference in pain intensity between the two groups was observed during the follow-up period without TEAS intervention (week 4, OR = 0.83, P > 0.05; week 5, OR = 0.83, P > 0.05). The Karnofsky Performance Status value suggested that patients in the true TEAS group experienced an improved quality of life (Between-group differences: week 3, 3.5%, P < 0.05; week 4, 4.6%, P < 0.001; week 5, 5.6%, P < 0.001).Conclusions The 3-week application of TEAS in patients with CRP receiving chronic opioid therapy resulted in a statistically significant reduction in pain scores, but the observed reduction was of uncertain clinical significance. The prolonged analgesic effect of TEAS was not confirmed in this trial.ClinicalTrial.gov ChiCTR-TRC-13003803.
C1 [Lyu, Zhengyi; Tian, Shuxin; Liu, Yang] Zhejiang Chinese Med Univ, Clin Med Coll 3, Hangzhou 310005, Peoples R China.
   [Bao, Guanai; Gong, Liyan; Kong, Xiangming] Zhejiang Canc Hosp, Dept Integrated Tradit Chinese Med & Western Med, Hangzhou 310022, Peoples R China.
   [Huang, Rui] Wenzhou Cent Hosp, Dept Acupuncture & Tuina, Wenzhou 325000, Peoples R China.
   [Zhou, Jie; Nie, Na; Shao, Xiaomei; Lin, Xianming; Fang, Jianqiao; Liang, Yi] Zhejiang Chinese Med Univ, Dept Acupuncture, Affiliated Hosp 3, Hangzhou 310000, Peoples R China.
   [Zhang, Weiping; Ran, Ran] Zhejiang Chinese Med Univ, Dept Oncol, Affiliated Hosp 3, Hangzhou 310000, Peoples R China.
   [Ji, Conghua; Kai, Guoyin] Zhejiang Chinese Med Univ, Hangzhou 310005, Peoples R China.
   [Liu, Shan] Zhejiang Prov Hosp Tradit Chinese Med, Dept Clin Evaluat Ctr, Hangzhou 310000, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Cancer Hospital; Zhejiang
   Chinese Medical University; Zhejiang Chinese Medical University;
   Zhejiang Chinese Medical University; Zhejiang Chinese Medical University
RP Fang, JQ; Liang, Y (corresponding author), Zhejiang Chinese Med Univ, Dept Acupuncture, Affiliated Hosp 3, Hangzhou 310000, Peoples R China.
EM aprilv_kuco@icloud.com; tianshuxin@zcmu.edu.cn; doctorbga@126.com;
   364742303@qq.com; susang409@hotmail.com; zhoujie0111@163.com;
   zjzlfyk@163.com; 15325715566@163.com; Ran2909@163.com;
   niena0616@126.com; ly1104938989@163.com; jchi_2005@163.com;
   liushan@zcmu.edu.cn; 13185097375@163.com; kaiguoyin@163.com;
   linxianming66@126.com; fangjianqiao7532@163.com; liangyiwww@126.com
RI Kai, Guoyin/GWC-5827-2022; Ran, Ran/AHC-1848-2022
FU National Key Research and Development Program of China
FX We extend our gratitude to Professor Mao and her team from the School of
   Public Health at Zhejiang Chinese Medicine University for their valuable
   statistical support. We would like to thank Erasmus Shannah Rose for the
   language review of this paper. Additionally, we appreciate the
   dedication of the medical and nursing staff at the trial sites, as well
   as the patients who participated in the study.
CR Anekar AA, 2023, StatPearls
   Ao L, 2021, EXP THER MED, V21, DOI 10.3892/etm.2021.9615
   Bennett MI, 2010, J PAIN, V11, P351, DOI 10.1016/j.jpain.2009.08.002
   Caraceni A, 2012, LANCET ONCOL, V13, pE58, DOI 10.1016/S1470-2045(12)70040-2
   Corli O, 2016, ANN ONCOL, V27, P1107, DOI 10.1093/annonc/mdw097
   Dowell D, 2016, MMWR RECOMM REP, V65, P1, DOI 10.15585/mmwr.rr6501e1
   Dworkin RH, 2008, J PAIN, V9, P105, DOI 10.1016/j.jpain.2007.09.005
   Dworkin RH, 2012, PAIN, V153, P1148, DOI 10.1016/j.pain.2012.03.003
   Fang Jiun-qiao, 2006, Zhongguo Zhen Jiu, V26, P11
   Gadsby J.G., 1997, Complementary Ther Med, V5, P13, DOI [10.1016/S0965-2299(97)80084-2, DOI 10.1016/S0965-2299(97)80084-2]
   Gavronsky S, 2012, PAIN MANAG NURS, V13, P150, DOI 10.1016/j.pmn.2009.08.001
   Ge L, 2022, CHIN MED-UK, V17, DOI 10.1186/s13020-021-00558-4
   Gewandter JS, 2021, PAIN, V162, P2669, DOI 10.1097/j.pain.0000000000002283
   Gibson W, 2019, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD011890.pub2, 10.1002/14651858.CD011890.pub3]
   Gomes T, 2018, JAMA NETW OPEN, V1, DOI 10.1001/jamanetworkopen.2018.0217
   GRIECO A, 1984, HEALTH PSYCHOL, V3, P129, DOI 10.1037/0278-6133.3.2.129
   Hale M, 2017, LANCET GASTROENTEROL, V2, P555, DOI 10.1016/S2468-1253(17)30105-X
   Han JS, 2011, NEUROSCI BIOBEHAV R, V35, P680, DOI 10.1016/j.neubiorev.2010.08.006
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hurlow A, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006276.pub3
   Liang Y, 2019, TRIALS, V20, DOI 10.1186/s13063-018-3145-y
   Liou KT, 2021, SUPPORT CARE CANCER, V29, P427, DOI 10.1007/s00520-020-05504-y
   Liou KT, 2021, J GEN INTERN MED, V36, P527, DOI 10.1007/s11606-020-05871-6
   Liu GG, 2014, VALUE HEALTH, V17, P597, DOI 10.1016/j.jval.2014.05.007
   Lu WD, 2018, HEMATOL ONCOL CLIN N, V32, P519, DOI 10.1016/j.hoc.2018.01.009
   Lu WD, 2010, CURR TREAT OPTION ON, V11, P141, DOI 10.1007/s11864-010-0126-0
   Lu ZH, 2021, J CLIN ANESTH, V74, DOI 10.1016/j.jclinane.2021.110453
   Meng D, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000026348
   Mosley M, 2014, MD Confer Exp, V14, P6
   Nakano J, 2020, INT J REHABIL RES, V43, P62, DOI 10.1097/MRR.0000000000000386
   Neufeld NJ, 2017, FUTURE ONCOL, V13, P833, DOI 10.2217/fon-2016-0423
   Ng JY, 2021, PAIN PRACT, V21, P454, DOI 10.1111/papr.12964
   Pargeon KL, 1999, J PAIN SYMPTOM MANAG, V18, P358, DOI 10.1016/S0885-3924(99)00097-4
   Plante GE, 2010, METABOLISM, V59, pS47, DOI 10.1016/j.metabol.2010.07.010
   Qu F, 2017, J ZHEJIANG UNIV-SC B, V18, P186, DOI 10.1631/jzus.B1600437
   Robb KA, 2007, J PAIN SYMPTOM MANAG, V33, P410, DOI 10.1016/j.jpainsymman.2006.09.020
   Song BJ, 2020, NAT SCI SLEEP, V12, P809, DOI 10.2147/NSS.S270739
   Swarm RA, 2019, J NATL COMPR CANC NE, V17, P977, DOI 10.6004/jnccn.2019.0038
   Szmit M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10010146
   Takahashi T, 2006, J GASTROENTEROL, V41, P408, DOI 10.1007/s00535-006-1773-6
   Tao WW, 2016, J PAIN SYMPTOM MANAG, V51, P728, DOI 10.1016/j.jpainsymman.2015.11.027
   Turan Zeynep, 2020, Turk J Phys Med Rehabil, V66, P210, DOI [10.5606/tftrd.2020.6484, 10.5606/tftrd.2020.6484]
   van den Beuken-van Everdingen MHJ, 2016, J PAIN SYMPTOM MANAG, V51, P1070, DOI 10.1016/j.jpainsymman.2015.12.340
   Wiffen PJ, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012592.pub2
   Williamson A, 2005, J CLIN NURS, V14, P798, DOI 10.1111/j.1365-2702.2005.01121.x
   Wu GJ, 2020, J CLIN GASTROENTEROL, V54, P536, DOI 10.1097/MCG.0000000000001184
   Xiao Y, 2022, CLIN TRANSL GASTROEN, V13, DOI 10.14309/ctg.0000000000000485
   Yang J, 2020, J PAIN RES, V13, P411, DOI 10.2147/JPR.S244173
   Zhou JY, 2022, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.1038922
   Zhou X, 2021, CANCER MANAG RES, V13, P1449, DOI 10.2147/CMAR.S292325
NR 51
TC 12
Z9 12
U1 4
U2 24
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JAN
PY 2024
VL 32
IS 1
AR 16
DI 10.1007/s00520-023-08240-1
PG 12
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA CH6L4
UT WOS:001124400900001
PM 38085376
DA 2026-01-16
ER

PT J
AU Xu, X
   Zhou, MM
   Hao, HY
   Chen, HY
AF Xu, Xiao
   Zhou, Ming-Ming
   Hao, Hai-Yan
   Chen, Hai-Yan
TI Enhancing peri-operative pain management in urological cancer: exploring
   the role of acupuncture
SO BJU INTERNATIONAL
LA English
DT Letter
C1 [Xu, Xiao; Zhou, Ming-Ming] Nantong Hlth Coll Jiangsu Prov, Res Ctr Mol Med, PhD Lab, Nantong, Peoples R China.
   [Xu, Xiao; Zhou, Ming-Ming] Nantong Hlth Coll Jiangsu Prov, Dept Nursing, Nantong, Peoples R China.
   [Hao, Hai-Yan] Nantong Univ, Affiliated Hosp, Clin Res Unit, Nantong, Peoples R China.
   [Chen, Hai-Yan] Nanjing Univ Chinese Med, Nantong Hosp Tradit Chinese Med, Affiliated Nantong Hosp, Dept Urol, Nantong 226001, Peoples R China.
C3 Nantong University; Nanjing University of Chinese Medicine
RP Hao, HY (corresponding author), Nantong Univ, Affiliated Hosp, Clin Res Unit, Nantong, Peoples R China.; Chen, HY (corresponding author), Nanjing Univ Chinese Med, Nantong Hosp Tradit Chinese Med, Affiliated Nantong Hosp, Dept Urol, Nantong 226001, Peoples R China.
EM haohaiyan001@outlook.com; chaiy2022@outlook.com
RI Hao, Haiyan/AFK-0917-2022; Xu, Xiao/K-5069-2019
OI Xu, Xiao/0000-0001-9272-6236
FU Nantong Municipal Health Commission [MS2023004]
FX This study was supported by the Nantong Municipal Health Commission
   (MS2023004).
CR Doan LV, 2020, CURR ANESTHESIOL REP, V10, P28, DOI 10.1007/s40140-020-00367-9
   He BJ, 2013, PAIN MED, V14, P1608, DOI 10.1111/pme.12197
   Lee YS, 2018, ACUPUNCT MED, V36, P197, DOI 10.1136/acupmed-2017-011516
   Maurer J, 2024, BJU INT, V133, P725, DOI 10.1111/bju.16288
NR 4
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-4096
EI 1464-410X
J9 BJU INT
JI BJU Int.
PD JUN
PY 2025
VL 135
IS 6
BP 1060
EP 1061
DI 10.1111/bju.16700
EA MAR 2025
PG 2
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 2GI8O
UT WOS:001447455300001
PM 40104920
OA Bronze
DA 2026-01-16
ER

PT J
AU Lopez, G
   Garcia, MK
   Liu, WL
   Spano, M
   Underwood, S
   Dibaj, SS
   Li, YS
   Moguel, R
   Williams, J
   Bruera, E
   Cohen, L
AF Lopez, Gabriel
   Garcia, M. Kay
   Liu, Wenli
   Spano, Michael
   Underwood, Susan
   Dibaj, Seyedeh S.
   Li, Yisheng
   Moguel, Rocio
   Williams, Janet
   Bruera, Eduardo
   Cohen, Lorenzo
TI Outpatient acupuncture effects on patient self-reported symptoms in
   oncology care: a retrospective analysis
SO JOURNAL OF CANCER
LA English
DT Article
DE Integrative Medicine; Integrative Oncology; Acupuncture; Complementary
   health approach; Patient Reported Outcomes; Edmonton Symptom Assessment
   System
ID CANCER-PATIENTS; PAIN
AB Background: Increased access to complementary therapies such as acupuncture at academic medical centers has created new opportunities for management of cancer and cancer treatment related symptoms.
   Methods: Patients presenting for acupuncture treatment during calendar year 2016 at an outpatient integrative medicine clinic in a comprehensive cancer center were asked to complete a modified Edmonton Symptom Assessment Scale (ESAS; 16 symptoms, score 0-10, 10 worst possible) before and after each visit. ESAS subscales analyzed included global (GDS; score 0-90), physical (PHS, 0-60) and psychological distress (PSS, 0-20). ESAS symptom score change pre/post acupuncture treatment & from baseline visit to first follow up were evaluated by paired t-test.
   Results: Of 375 participants [mean age 55.6, 68.3% female, 73.9% white, most common cancer diagnosis of breast (32.8%) and thoracic/head & neck (25.9%)], 73.3% had at least one follow up acupuncture treatment [mean 4.6 (SD 5.1) treatments]. Highest/worst symptoms at baseline were poor sleep (3.92), fatigue (3.43), well-being (3.31), and pain (3.29). Statistically significant reduction/improvement (pre/post) was observed for all ESAS symptoms and subscales for the initial acupuncture treatment (p <0.001). Hot flashes had the highest mean reduction (-1.93), followed by fatigue (-1.72), numbness/tingling (-1.70), and nausea (-1.67). Clinically significant reductions were also observed for ESAS subscales of GDS (-12.2), PHS (-8.5), and PSS (-2.6). For symptom change from initial acupuncture treatment to first follow up (pre/pre), statistically and clinically significant improvement was observed for spiritual pain (-1.10; p<0.001) and ESAS subscale of GDS (-6.09; p=0.048). Clinical response rates (reduction >= 1) on follow up were highest for symptoms of spiritual pain (58.9%), dry mouth (57.8%) and nausea (57.3%).
   Conclusions: Outpatient acupuncture was associated with immediate & longitudinal significant improvement across a range of symptoms commonly experienced by individuals during cancer care. Further research is needed to better understand frequency of treatments needed in clinical practice to help maintain benefit.
C1 [Lopez, Gabriel; Garcia, M. Kay; Liu, Wenli; Spano, Michael; Underwood, Susan; Moguel, Rocio; Williams, Janet; Bruera, Eduardo; Cohen, Lorenzo] Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, Houston, TX 77030 USA.
   [Dibaj, Seyedeh S.; Li, Yisheng] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; UTMD Anderson Cancer Center
RP Lopez, G (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, Houston, TX 77030 USA.
EM gabriel.lopez@mdanderson.org
RI Underwood, Susan/Z-4897-2019; liu, wenli/JRW-0517-2023; Bruera,
   Eduardo/AAA-1550-2022
FU Duncan Family Institute for Cancer Prevention and Risk Assessment
FX This research study was supported in part by funding from the Duncan
   Family Institute for Cancer Prevention and Risk Assessment.
CR Bruera E, 1991, J Palliat Care, V7, P6
   Delgado-Guay MO, 2016, PALLIAT SUPPORT CARE, V14, P341, DOI 10.1017/S147895151500108X
   Garcia MK, 2018, INTEGR CANCER THER, V17, P148, DOI 10.1177/1534735416685403
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   HERSHMAN DL, 2017, SAN ANT BREAST CANC
   Hui D, 2016, J PAIN SYMPTOM MANAG, V51, P262, DOI 10.1016/j.jpainsymman.2015.10.004
   Hui D, 2015, CANCER-AM CANCER SOC, V121, P3027, DOI 10.1002/cncr.29437
   Lopez G, 2017, J CANCER, V8, P395, DOI 10.7150/jca.17506
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Melchart D, 2004, ARCH INTERN MED, V164, P104, DOI 10.1001/archinte.164.1.104
   Tick H, 2018, EXPLORE-NY, V14, P177, DOI 10.1016/j.explore.2018.02.001
   Witt CM, 2017, J NATL CANC I MONOGR, V2017
   Yun H, 2017, J NATL CANC I MONOGR, V2017
   Zia FZ, 2017, JNCI MONOGRAPHS, V2017
NR 14
TC 21
Z9 25
U1 0
U2 5
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1837-9664
J9 J CANCER
JI J. Cancer
PY 2018
VL 9
IS 19
BP 3613
EP 3619
DI 10.7150/jca.26527
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GS9EM
UT WOS:000444018800021
PM 30310519
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ylva, W
   Per, F
   Anna, E
AF Ylva, Widgren
   Per, Fransson
   Anna, Efverman
TI Acupuncture in Patients Undergoing Cancer Therapy: Their Interest and
   Belief in Acupuncture is High, But Few are Using It
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture therapy; attitudes; cancer survivors; complementary and
   alternative medicine; expectations; oncology nursing
ID ALTERNATIVE MEDICINE; COMPLEMENTARY; EXPECTATIONS; SURVIVORS; OUTCOMES;
   HEALTH
AB Objectives: Since pre-existing expectations, that is, beliefs, in a treatment may modify outcomes, and acupuncture studies often fail to measure expectations, we wanted to investigate the use of acupuncture, interest, and belief in acupuncture effects among patients undergoing cancer therapy. Method: A cross-sectional design, where the participants answered a study-specific questionnaire with questions regarding their use of, interest and belief in acupuncture treatment. Results: A total of 457 patients with cancer (48% men, mean age 65 years) answered the questionnaire. Acupuncture was used by 4 (1%) patients during their cancer therapy, and 368 (83%) expressed an interest in receiving acupuncture. Of the 457 patients, 289 (63%) believed acupuncture to be effective for at least 1 of 17 requested symptoms, most commonly pain (56% of the patients) and muscle tension (40%). They believed acupuncture to be effective for a mean value 3 of the 17 requested symptoms. Women (P < .001), and patients 41 to 65 years (P < .001), expressed a stronger belief in acupuncture effects than others. Conclusions: Men and older patients expressed weaker beliefs in acupuncture effects than other patients, indicating the importance of collecting expectancy data in future randomized sham-controlled acupuncture studies to be able to treat expectancy as an effect-modifier. The high interest and beliefs in acupuncture effects found also indicate that acupuncture should be available for patients with cancer, for side effects where acupuncture has shown to be effective. In a clinical setting, older men might need more encouragement regarding positive expected outcomes of the acupuncture treatment than younger women.
C1 [Ylva, Widgren; Anna, Efverman] Univ Gavle, Gavle, Sweden.
   [Ylva, Widgren] Region Hosp Sundsvall Harnosand, Cty Council Vasternorrland, Vasternorrland, Sweden.
   [Per, Fransson] Umea Univ, Umea, Sweden.
   [Per, Fransson] Umea Univ Hosp, Umea, Sweden.
C3 University of Gavle; Umea University; Umea University; Umea University
   Hospital
RP Ylva, W (corresponding author), Univ Gavle, Fac Hlth & Occupat Studies, Dept Caring Sci, S-80176 Gavle, Sweden.
EM ylva.widgren@hig.se
CR Bauml Joshua, 2014, Journal of the National Cancer Institute Monographs, P302, DOI 10.1093/jncimonographs/lgu029
   Bausewein C, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005623.pub2
   Buettner C, 2006, BREAST CANCER RES TR, V100, P219, DOI 10.1007/s10549-006-9239-3
   Carmady B, 2011, CHIN MED-UK, V6, DOI 10.1186/1749-8546-6-22
   Choi TY, 2017, INTEGR CANCER THER, V16, P135, DOI 10.1177/1534735416664172
   Colagiuri B, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/857804
   Colloca L, 2009, PAIN, V144, P28, DOI 10.1016/j.pain.2009.01.033
   Dai L, 2021, J PALLIAT MED, V24, P1078, DOI 10.1089/jpm.2020.0405
   Davis EL, 2012, ONCOLOGIST, V17, P1475, DOI 10.1634/theoncologist.2012-0223
   Efverman A, 2020, COMPLEMENT THER MED, V52, DOI 10.1016/j.ctim.2020.102404
   Enblom A, 2017, ACUPUNCT MED, V35, P251, DOI 10.1136/acupmed-2015-011007
   Enblom A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014766
   Enblom A, 2009, SUPPORT CARE CANCER, V17, P23, DOI 10.1007/s00520-008-0445-x
   Fava GA, 2012, INT J CLIN PRACT, V66, P11, DOI 10.1111/j.1742-1241.2011.02825.x
   Forde JC, 2016, INT UROGYNECOL J, V27, P1645, DOI 10.1007/s00192-015-2935-y
   Garcia GT, 2021, MED ACUPUNCT, V33, P22, DOI 10.1089/acu.2020.1431
   Garcia MK, 2015, CANCER-AM CANCER SOC, V121, P3948, DOI 10.1002/cncr.29630
   Gras M, 2019, ONCOLOGY-BASEL, V97, P18, DOI 10.1159/000499629
   Haddad NE, 2014, INTEGR CANCER THER, V13, P371, DOI 10.1177/1534735413520181
   Hanssen B, 2005, SCAND J PRIM HEALTH, V23, P57, DOI 10.1080/02813430510018419
   Hunter T, 2014, EUR J PAIN, V18, P914, DOI 10.1002/j.1532-2149.2013.00436.x
   Jang S, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021820
   Kaptchuk TJ, 2020, BMJ-BRIT MED J, V370, DOI 10.1136/bmj.m1668
   Kelley JM, 2009, PSYCHOSOM MED, V71, P789, DOI 10.1097/PSY.0b013e3181acee12
   Kessel KA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165801
   Lee I, 2017, ACUPUNCT MED, V35, DOI 10.1136/acupmed-2016-011056
   Lettner S, 2017, STRAHLENTHER ONKOL, V193, P419, DOI 10.1007/s00066-017-1101-5
   Lian WL, 2014, CHIN J INTEGR MED, V20, P136, DOI 10.1007/s11655-013-1439-1
   Linde K, 2007, PAIN, V128, P264, DOI 10.1016/j.pain.2006.12.006
   Loquai C, 2017, EUR J CANCER, V71, P70, DOI 10.1016/j.ejca.2016.10.029
   Mao JJ, 2010, ALTERN THER HEALTH M, V16, P22
   Mitchell C, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002088.pub3
   Ni XX, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420980825
   Nissen N, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-388
   Prady SL, 2015, COMPLEMENT THER MED, V23, P185, DOI 10.1016/j.ctim.2015.01.007
   Rabin R, 2001, ANN MED, V33, P337, DOI 10.3109/07853890109002087
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Rossi E, 2015, SUPPORT CARE CANCER, V23, P1795, DOI 10.1007/s00520-014-2517-4
   Sharp Debbie, 2018, BJGP Open, V2, pbjgpopen18X101614, DOI [10.3399/bjgpopen18x101614, 10.3399/bjgpopen18X101614]
   Shay LA, 2015, MED DECIS MAKING, V35, P114, DOI 10.1177/0272989X14551638
   Steineck G, 2002, ACTA ONCOL, V41, P244, DOI 10.1080/02841860260088782
   Steineck G, 2002, NEW ENGL J MED, V347, P790, DOI 10.1056/NEJMoa021483
   Stub T, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2106-z
   Widgren Y., 2021, IMPORTANCE STR UNPUB
   Witt CM., 2017, J NATL CANC I MONOGR, V2017
   Wode K, 2019, BMC COMPLEM ALTERN M, V19, DOI 10.1186/s12906-019-2452-5
   Xu MM, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003317.pub3
NR 47
TC 10
Z9 10
U1 1
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD FEB
PY 2022
VL 21
AR 15347354221077277
DI 10.1177/15347354221077277
PG 11
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA ZO7AW
UT WOS:000765880900001
PM 35212241
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Luo, Y
   Wang, CZ
   Sawadogo, R
   Tan, T
   Yuan, CS
AF Luo, Yun
   Wang, Chong-Zhi
   Sawadogo, Richard
   Tan, Ting
   Yuan, Chun-Su
TI Effects of Herbal Medicines on Pain Management
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Pain; Nociception; NSAIDS; Opioids; Herbal Medicine; Chinese Medicine;
   Corydalis yanhusuo; Ligusticum chuanxiong; Aconitum carmichaeli; Chinese
   Herbal Formulation; Review
ID TRADITIONAL CHINESE MEDICINE; LOW-BACK-PAIN; PANAX-NOTOGINSENG;
   NEUROPATHIC PAIN; ACUPUNCTURE; EFFICACY; BULLEYACONITINE; FORMULA;
   DISEASE
AB Pain is an unpleasant sensory and emotional experience in many diseases and is often caused by intense or damaging stimuli. Pain negatively affects the quality of life and increases high health expenditures. Drugs with analgesic properties are commonly used to relieve pain, but these Western medications could be overwhelmed by side effects including tolerance and addiction. Herbal medicines may provide alternative measures for pain management. In this review paper, after introduction of Chinese medicine theory and treatment modality, emphasis is placed on the application of Chinese herbs and herbal formulations in pain management. Three of the most commonly used herbs, i.e., Corydalis yanhusuo, Ligusticum chuanxiong, and Aconitum carmichaeli, are reviewed. Subsequently, using this ancient medical remedy, Chinese herbal formulation in treating common medical conditions associated with pain, such as headache/migraine, chest pain, abdominal pain, low back pain, neuropathic pain, osteoarthritis, and cancer pain, is presented. Chinese herbal medicines could be considered as a complementary and integrative approach in the modern armamentarium in combating pain.
C1 [Luo, Yun; Tan, Ting] Jiangxi Univ Tradit Chinese Med, Minist Educ, Key Lab Modern Preparat Tradit Chinese Med, Nanchang 330004, Jiangxi, Peoples R China.
   [Luo, Yun; Wang, Chong-Zhi; Sawadogo, Richard; Yuan, Chun-Su] Univ Chicago, Pritzker Sch Med, Tang Ctr Herbal Med Res, 5841 South Maryland Ave,MC 4028, Chicago, IL 60637 USA.
   [Luo, Yun; Wang, Chong-Zhi; Sawadogo, Richard; Yuan, Chun-Su] Univ Chicago, Pritzker Sch Med, Dept Anesthesia & Crit Care, 5841 South Maryland Ave,MC 4028, Chicago, IL 60637 USA.
   [Yuan, Chun-Su] Univ Chicago, Pritzker Sch Med, Comm Clin Pharmacol & Pharmacogen, Chicago, IL 60637 USA.
   [Sawadogo, Richard] Inst Hlth Sci Res, 03 BP 7192, Ouagadougou 03, Burkina Faso.
C3 Jiangxi University of Traditional Chinese Medicine; University of
   Chicago; University of Chicago; University of Chicago
RP Yuan, CS (corresponding author), Univ Chicago, Pritzker Sch Med, Tang Ctr Herbal Med Res, 5841 South Maryland Ave,MC 4028, Chicago, IL 60637 USA.; Yuan, CS (corresponding author), Univ Chicago, Pritzker Sch Med, Dept Anesthesia & Crit Care, 5841 South Maryland Ave,MC 4028, Chicago, IL 60637 USA.
EM cyuan@dacc.uchicago.edu
RI Wang, Chong-Zhi/B-8337-2014
FU National Natural Science Foundation of China [81760711, 81460600,
   81603274]; State Scholarship Fund of China Scholarship Council
   [201808360056]; Natural Science Foundation of Jiangxi Province, China
   [20171BAB205100, 20181BAB205080]; 111 Project from the Ministry of
   Education of China [B16046]; State Administration of Foreign Experts
   Affairs of China [B16046]; Fulbright Visiting Scholars Program from the
   U.S. Department of State [PS00267280]; U.S. National Institutes of
   Health [AT004418, 5P30DK042086]
FX This work was supported by the grants of the National Natural Science
   Foundation of China (81760711, 81460600 and 81603274), the State
   Scholarship Fund of China Scholarship Council (201808360056), the
   Natural Science Foundation of Jiangxi Province, China (20171BAB205100
   and 20181BAB205080), the 111 Project from the Ministry of Education of
   China and the State Administration of Foreign Experts Affairs of China
   (B16046), the Fulbright Visiting Scholars Program from the U.S.
   Department of State (PS00267280), and U.S. National Institutes of Health
   grants (AT004418 and 5P30DK042086).
CR Abrams J, 2005, NEW ENGL J MED, V352, P2524, DOI 10.1056/NEJMcp042317
   Bardia A, 2006, J CLIN ONCOL, V24, P5457, DOI 10.1200/JCO.2006.08.3725
   Burch R, 2018, HEADACHE, V58, P496, DOI 10.1111/head.13281
   Cai W, 2018, AM J CHINESE MED, V46, P515, DOI 10.1142/S0192415X1850026X
   Cao KG, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1321-8
   Charles A, 2017, NEW ENGL J MED, V377, P553, DOI 10.1056/NEJMcp1605502
   Chen H. M., 2012, AM J CHINESE MED, V47, P1
   Chen M, 2018, ALIMENT PHARM THER, V48, P160, DOI 10.1111/apt.14817
   Chen ZJ, 2018, FOOD CHEM TOXICOL, V119, P309, DOI 10.1016/j.fct.2018.02.050
   Dai YC, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006651
   Demsie DG, 2019, J PAIN RES, V12, P1399, DOI 10.2147/JPR.S193029
   Dong PX, 2018, CHIN MED-UK, V13, DOI 10.1186/s13020-018-0185-x
   Duan L, 2018, PHYTOMEDICINE, V47, P23, DOI 10.1016/j.phymed.2018.04.044
   Fan H, 2017, CLIN GASTROENTEROL H, V15, P1724, DOI 10.1016/j.cgh.2017.06.026
   Fang RM, 2018, AM J CHINESE MED, V46, P1609, DOI 10.1142/S0192415X18500829
   Feng L, 2014, AM J CHINESE MED, V42, P109, DOI 10.1142/S0192415X14500074
   Fu CH, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/967968
   Fung F.Y., 2015, ALTERNAT MED, V2015
   Gagnier JJ, 2016, SPINE, V41, P116, DOI 10.1097/BRS.0000000000001310
   Gilron I, 2005, NEW ENGL J MED, V352, P1324, DOI 10.1056/NEJMoa042580
   Guo ZG, 2014, SCI REP-UK, V4, DOI 10.1038/srep03905
   Hamaguchi T, 2017, J ALTERN COMPLEM MED, V23, P208, DOI 10.1089/acm.2016.0276
   Huang YL, 2019, AM J CHINESE MED, V47, P727, DOI 10.1142/S0192415X19500381
   Huo WW, 2018, MOL PAIN, V14, DOI 10.1177/1744806918781733
   Jia W, 2006, PHYTOTHER RES, V20, P819, DOI 10.1002/ptr.1905
   Lao L, 2015, OSTEOARTHR CARTILAGE, V23, P2102, DOI 10.1016/j.joca.2015.06.007
   Lee H, 2016, MATURITAS, V86, P64, DOI 10.1016/j.maturitas.2016.01.012
   Li JH, 2015, COMPLEMENT THER MED, V23, P577, DOI 10.1016/j.ctim.2015.06.012
   Li LR, 2019, AM J CHINESE MED, V47, P495, DOI 10.1142/S0192415X19500253
   Lin JG, 2018, AM J CHINESE MED, V46, P55, DOI 10.1142/S0192415X18500039
   Liu S, 2017, J ETHNOPHARMACOL, V207, P237, DOI 10.1016/j.jep.2017.06.038
   Luan F, 2019, AM J CHINESE MED, V47, P959, DOI [10.1142/s0192415x19500502, 10.1142/S0192415X19500502]
   Luo Y, 2019, AM J CHINESE MED, V47, P1223, DOI 10.1142/S0192415X19500629
   Martyn JAJ, 2019, NEW ENGL J MED, V380, P365, DOI 10.1056/NEJMra1800222
   Moore RA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010794.pub2
   Pan H, 2018, AM J CHINESE MED, V46, P489, DOI 10.1142/S0192415X18500258
   Patil S, 2016, CURR PAIN HEADACHE R, V20, DOI 10.1007/s11916-016-0552-1
   Peirs C, 2016, SCIENCE, V354, P578, DOI 10.1126/science.aaf8933
   Peng C, 2009, PHYTOMEDICINE, V16, P25, DOI 10.1016/j.phymed.2008.10.010
   Qi FH, 2015, BIOSCI TRENDS, V9, P16, DOI 10.5582/bst.2015.01019
   Qi Y, 2012, J EVID BASED MED, V11, P83
   Ran X, 2011, PHARM BIOL, V49, P1180, DOI 10.3109/13880209.2011.576346
   Shirazi M, 2017, J EVID-BASED INTEGR, V22, P120, DOI 10.1177/2156587216654601
   Singhuber J, 2009, J ETHNOPHARMACOL, V126, P18, DOI 10.1016/j.jep.2009.07.031
   Sommer C, 2016, SCIENCE, V354, P588, DOI 10.1126/science.aaf8935
   Straube A, 2019, J HEADACHE PAIN, V20, DOI 10.1186/s10194-019-0985-0
   Sun ML, 2018, PSYCHOPHARMACOLOGY, V235, P2559, DOI 10.1007/s00213-018-4948-y
   Suzuki T, 2016, J ETHNOPHARMACOL, V186, P44, DOI 10.1016/j.jep.2016.03.056
   Takao Yumiko, 2015, Kobe J Med Sci, V61, pE132
   Tomioka H, 2017, AM J CHINESE MED, V45, P1597, DOI 10.1142/S0192415X17500860
   Tsai CI, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/767498
   Viniol A, 2014, FAM PRACT, V31, P517, DOI 10.1093/fampra/cmu036
   Wang F, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/1827528
   Wang HY, 2018, AM J CHINESE MED, V46, P1387, DOI 10.1142/S0192415X18500738
   WANG L, 2016, EVID-BASED COMPL ALT, DOI DOI 10.1155/2016/7960503
   Wang L, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162875
   Wang SM, 2018, AM J CHINESE MED, V46, P953, DOI 10.1142/S0192415X18500507
   Wang ZY, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/7191856
   Williams ACD, 2016, PAIN, V157, P2420, DOI 10.1097/j.pain.0000000000000613
   Woolf CJ, 2010, J CLIN INVEST, V120, P3742, DOI 10.1172/JCI45178
   Wu LH, 2018, MOLECULES, V23, DOI 10.3390/molecules23102585
   Xie MX, 2018, MOL PAIN, V14, DOI 10.1177/1744806918797243
   Xiong W, 2018, AM J CHINESE MED, V46, P1169, DOI 10.1142/S0192415X18500611
   Xu Y, 2016, ONCOTARGET, V7, P20455, DOI 10.18632/oncotarget.7973
   Xu Y, 2018, AM J CHINESE MED, V46, P971, DOI [10.1142/s0192415x18500519, 10.1142/S0192415X18500519]
   Xu Z.H, 2018, AM J CHIN MED, P1
   Yeh LLL, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000719
   Yu SY, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/694061
   Yu YN, 2014, SCI REP-UK, V4, DOI 10.1038/srep07058
   Zhan JYX, 2013, PLANTA MED, V79, P533, DOI 10.1055/s-0032-1328261
   Zhang D, 2016, MEDICINE, V95, P51
   Zhang W, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-008973corr1
   Zhao LX, 2014, EUR J NEUROSCI, V39, P1391, DOI 10.1111/ejn.12502
   Zhu HQ, 2015, EXP NEUROL, V273, P263, DOI 10.1016/j.expneurol.2015.09.006
   Zhu MD, 2014, BRAIN RES BULL, V109, P54, DOI 10.1016/j.brainresbull.2014.10.002
NR 75
TC 71
Z9 76
U1 5
U2 83
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2020
VL 48
IS 1
BP 1
EP 16
DI 10.1142/S0192415X20500019
PG 16
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA KN9GX
UT WOS:000515156400001
PM 32054304
DA 2026-01-16
ER

PT J
AU Mahfudh, SS
AF Mahfudh, Salma Said
TI Historical Perspectives and Trends in the Management of Pain for Cancer
   Patients in Oman
SO ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
LA English
DT Article
DE Cancer pain; management; Sultanate of Oman; WHO guidelines
AB Introduction. Sultanate of Oman is the second largest country in the Gulf, with a population of 2,867,428 (2008) of which 35.2% is under 15 years and only 3.7% above 65 years. Incidence of newly diagnosed cancers is also the second highest in the Gulf with 11%. Research conducted between 1997-2007 revealed that the most frequent cancers in males: stomach 10%, non-Hodgkins lymphoma 8.6% and prostate 7% while in females: breast 18.9%, thyroid 8.3% and cervix uteri 6.5%. A population-based registry was established in 1996 to compile an accurate database and monitor cancer trends. There is a rigorous follow up of reported cases. Unfortunately most patients report at the hospitals in advanced stages which complicate pain management. All treatment modalities of cancer are available in Oman at the two centers, Royal Hospital and SQUH. There is a continuous effort to develop national educational guidelines, protocols for cancer treatment, palliative care and pain management (PM). Historical Perspectives and Trends in the Management of Pain. In 1970s Omanis used traditional medicine, wassam (moxibustion), to treat pain. In 1988 severe pain was treated in hospitals with intramuscular opioid, whenever necessary (PRN). 1989 SQUH approved use of both parenteral and oral narcotics, received its first consignment, and started PM. The Ministry of Health (MOH) was concerned with possible misuse and for 8 years, thereafter, SQUH was the only hospital allowed to import, stock, prescribe and dispense oral narcotics. Legal requirement to obtain opioids in Oman involves MOH and World Health Organization (WHO) and there is a control as to who can prescribe for both inpatient and outpatient. The drugs available to control pain include non opioids, weak opioids, but the only strong opioids used for severe cancer pain are morphine and Fentanyl. This is complemented with adjuvant drugs. We use the "WHO Ladder" to guide us in the management of pain. Three different cases have been presented to see how PM of cancer patients has evolved from using only non-opioid in 1993, to using intramuscular pethidine in 1995, then to using morphine with adjuvants in 1999. Referral of patients to the PM Team has improved the pain control and at present even without referral, pain is controlled more effectively. Conclusion. There is no doubt that the Sultanate of Oman has progressed tremendously since 1970. The Government is working very hard and is taking major steps to improve cancer care in order to meet the International Bench Mark. Each 5 year plan focuses on actual needs. One of the important needs that have been addressed is the management of pain which has significantly improved. Factors that have improved PM in Oman include the introduction of the PM Teams, training of Nurses and Doctors, follow up of the PM services in the clinical areas, authorizing MOH hospitals to use oral opioids, opening of the National Oncology Centre with Radiation Therapy, inter institutional discussions and development of guidelines, implementation of WHO Guidelines on PM and audits, peer reviews and research.
C1 SQUH, Nursing Directorate, Al Khoud, Oman.
C3 Sultan Qaboos University
RP Mahfudh, SS (corresponding author), SQUH, Nursing Directorate, POB 38,Code 123, Al Khoud, Oman.
CR *GCC, GCC RES CTR REP 8YRS
   *MOH, 2008, OM CANC REP
   *SULT OM MOH, 2008, ANN HLTH REP SULT OM
   2009, OMAN OBSERVER    NOV
   2009, TIMES OMAN MOND 1207
NR 5
TC 4
Z9 4
U1 0
U2 11
PU ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
PI NAGOYA
PA 4-84 JOTO-CHO, KITA-KU, NAGOYA, 462-0831, JAPAN
SN 1513-7368
J9 ASIAN PAC J CANCER P
JI Asian Pac. J. Cancer Prev.
PD APR
PY 2010
VL 11
SU 1
BP 93
EP 96
PG 4
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 682DK
UT WOS:000284379900016
PM 20590357
DA 2026-01-16
ER

PT J
AU Yang, J
   Xiong, XY
   Wei, Q
   Yang, L
AF Yang, Jie
   Xiong, Xingyu
   Wei, Qiang
   Yang, Lu
TI Acupuncture: a promising adjuvant strategy for pain management among the
   patients with prostate cancer
SO BJU INTERNATIONAL
LA English
DT Letter
C1 [Yang, Jie; Xiong, Xingyu; Wei, Qiang; Yang, Lu] Sichuan Univ, West China Hosp, Inst Urol, Ctr Biomed Big Data,Dept Urol, Chengdu, Sichuan, Peoples R China.
   [Yang, Jie; Xiong, Xingyu; Wei, Qiang; Yang, Lu] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University
RP Wei, Q (corresponding author), Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Sichuan, Peoples R China.; Yang, L (corresponding author), Sichuan Univ, West China Hosp, Dept Urol, 37 Guoxue Lane, Chengdu 610041, Sichuan, Peoples R China.
EM wq933@hotmail.com; wycleflue@scu.edu.cn
RI Xiong, Xingyu/LZG-9303-2025; Yang, Jie/NVM-9552-2025
CR Bao T, 2018, ACUPUNCT MED, V36, P80, DOI 10.1136/acupmed-2017-011435
   de Sousa TR, 2023, J CLIN NURS, V32, P6917, DOI 10.1111/jocn.16812
   Maurer J, 2024, BJU INT, V133, P725, DOI 10.1111/bju.16288
NR 3
TC 0
Z9 0
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-4096
EI 1464-410X
J9 BJU INT
JI BJU Int.
PD OCT
PY 2024
VL 134
IS 4
BP 664
EP 665
DI 10.1111/bju.16467
EA JUL 2024
PG 2
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA L0Q6L
UT WOS:001271539800001
PM 39019800
DA 2026-01-16
ER

PT J
AU Qu, SY
   Wang, HZ
   Hu, QQ
   Ma, YQ
   Kang, YR
   Ma, LQ
   Li, X
   Chen, LH
   Liu, BY
   Shao, XM
   Liu, BY
   Du, JY
   Liang, Y
   Zhao, HL
   Jiang, YL
   Fang, JQ
   He, XF
AF Qu, Si-ying
   Wang, Han-zhi
   Hu, Qun-qi
   Ma, Yi-qi
   Kang, Yu-rong
   Ma, Li-qian
   Li, Xiang
   Chen, Lu-hang
   Liu, Bo-yu
   Shao, Xiao-mei
   Liu, Bo-yi
   Du, Jun-ying
   Liang, Yi
   Zhao, Hong-li
   Jiang, Yong-liang
   Fang, Jian-qiao
   He, Xiao-fen
TI Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting
   the microglia P2X4R and neuroinflammation
SO PURINERGIC SIGNALLING
LA English
DT Article
DE Electroacupuncture; Diabetic neuropathic pain; Spinal cord; Microglia
ID PERIPHERAL-NERVE INJURY; SPINAL MICROGLIA; UP-REGULATION; MECHANICAL
   ALLODYNIA; P2X(4) RECEPTORS; RAT MODEL; STREPTOZOTOCIN; ACTIVATION;
   CORD; EXPRESSION
AB Diabetic neuropathic pain (DNP) is a common and destructive complication of diabetes mellitus. The discovery of effective therapeutic methods for DNP is vitally imperative because of the lack of effective treatments. Although 2 Hz electroacupuncture (EA) was a successful approach for relieving DNP, the mechanism underlying the effect of EA on DNP is still poorly understood. Here, we established a rat model of DNP that was induced by streptozotocin (STZ) injection. P2X4R was upregulated in the spinal cord after STZ-injection. The upregulation of P2X4R was mainly expressed on activated microglia. Intrathecal injection of a P2X4R antagonist or microglia inhibitor attenuated STZ-induced nociceptive thermal hyperalgesia and reduced the overexpression of brain-derived neurotrophic factor (BDNF), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) in the spinal cord. We also assessed the effects of EA treatment on the pain hypersensitivities of DNP rats, and further investigated the possible mechanism underlying the analgesic effect of EA. EA relieved the hyperalgesia of DNP. In terms of mechanism, EA reduced the upregulation of P2X4R on activated microglia and decreased BDNF, IL-1 beta and TNF-alpha in the spinal cord. Mechanistic research of EA's analgesic impact would be beneficial in ensuring its prospective therapeutic effect on DNP as well as in extending EA's applicability.
C1 [Qu, Si-ying; Wang, Han-zhi; Hu, Qun-qi; Ma, Yi-qi; Kang, Yu-rong; Ma, Li-qian; Li, Xiang; Chen, Lu-hang; Liu, Bo-yu; Shao, Xiao-mei; Liu, Bo-yi; Du, Jun-ying; Liang, Yi; Jiang, Yong-liang; Fang, Jian-qiao; He, Xiao-fen] Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China.
   [Wang, Han-zhi; Zhao, Hong-li] Zhejiang Chinese Med Univ, Hangzhou Hosp Tradit Chinese Med, Dept TCM Gynecol, Hangzhou 310000, Peoples R China.
   [Liu, Bo-yu; Shao, Xiao-mei; Liu, Bo-yi; Du, Jun-ying; Liang, Yi; Jiang, Yong-liang; Fang, Jian-qiao; He, Xiao-fen] Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou 310053, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Zhejiang Chinese Medical University
RP Jiang, YL; Fang, JQ; He, XF (corresponding author), Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China.; Jiang, YL; Fang, JQ; He, XF (corresponding author), Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou 310053, Zhejiang, Peoples R China.
EM jyl2182@126.com; fangjianqiao7532@163.com; zjhxf1986@163.com
RI Zhao, Hongli/OJU-4239-2025; Du, Junying/AEV-3719-2022; Qu,
   Siying/OTI-2971-2025; Hu, Qunqi/HRD-3345-2023; 一齐, 马/JHT-6249-2023
FU National Natural Science Foundation of China [81804181, 81774389];
   Natural Science Foundation of Zhejiang Province of China [LY22H270006];
   Research Fund for Zhejiang Traditional Chinese Medicine University
   Affiliated Hospital [2022FSYYZZ09]; Key Laboratory of Acupuncture and
   Neurology of Zhejiang Province [2019E10011]
FX This research was supported by the National Natural Science Foundation
   of China (81804181 to X.F.H. and 81774389 to Y.L.J.), the Natural
   Science Foundation of Zhejiang Province of China (LY22H270006 to
   Y.L.J.), the Research Fund for Zhejiang Traditional Chinese Medicine
   University Affiliated Hospital (2022FSYYZZ09 to Y.L.J.), and the Key
   Laboratory of Acupuncture and Neurology of Zhejiang Province
   (2019E10011).
CR Abbott CA, 2011, DIABETES CARE, V34, P2220, DOI 10.2337/dc11-1108
   Burnstock G, 2008, NAT REV DRUG DISCOV, V7, P575, DOI 10.1038/nrd2605
   Butovsky O, 2018, NAT REV NEUROSCI, V19, P622, DOI 10.1038/s41583-018-0057-5
   Chen XM, 2015, BRIT J ANAESTH, V114, P150, DOI 10.1093/bja/aeu199
   Cheng KI, 2014, EUR J PAIN, V18, P162, DOI 10.1002/j.1532-2149.2013.00356.x
   Colburn RW, 1997, J NEUROIMMUNOL, V79, P163, DOI 10.1016/S0165-5728(97)00119-7
   Deng ZY, 2018, BRAIN RES BULL, V142, P138, DOI 10.1016/j.brainresbull.2018.07.003
   El-Hossary N, 2016, DIABETES RES CLIN PR, V121, P102, DOI 10.1016/j.diabres.2016.09.008
   Erbas O, 2016, DIABETES RES CLIN PR, V114, P106, DOI 10.1016/j.diabres.2015.12.016
   Fan WJ, 2017, CARDIOVASC ENDOCRINO, V6, P8, DOI 10.1097/XCE.0000000000000116
   Ginhoux F, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00045
   Gu YX, 2020, NEURAL PLAST, V2020, DOI 10.1155/2020/8861994
   Hao LJ, 2021, NEUROSCIENCE, V463, P216, DOI 10.1016/j.neuroscience.2021.03.009
   He XF, 2017, J ZHEJIANG UNIV-SC B, V18, P239, DOI 10.1631/jzus.B1600247
   Hu QQ, 2023, PURINERG SIGNAL, V19, P29, DOI 10.1007/s11302-022-09844-8
   Inoue K, 2021, PURINERG SIGNAL, V17, P41, DOI 10.1007/s11302-020-09743-w
   Inoue K, 2018, NAT REV NEUROSCI, V19, P138, DOI 10.1038/nrn.2018.2
   Ji RR, 2018, ANESTHESIOLOGY, V129, P343, DOI 10.1097/ALN.0000000000002130
   Ji RR, 2014, NAT REV DRUG DISCOV, V13, P533, DOI 10.1038/nrd4334
   Khakh BS, 2012, NEURON, V76, P51, DOI 10.1016/j.neuron.2012.09.024
   Kim C, 2016, MOLECULES, V21, DOI 10.3390/molecules21091253
   Lee JY, 2019, J GINSENG RES, V43, P58
   Li J, 2017, PURINERG SIGNAL, V13, P13, DOI 10.1007/s11302-016-9537-0
   Lv ZT, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1899-6
   Manitz MP, 2016, BRAIN RES, V1636, P172, DOI 10.1016/j.brainres.2016.02.004
   Miao JY, 2012, NEUROSCI RES, V74, P269, DOI 10.1016/j.neures.2012.09.001
   Morrow Thomas J, 2004, Curr Protoc Neurosci, VChapter 9, DOI 10.1002/0471142301.ns0918s29
   Peltier A, 2014, BMJ-BRIT MED J, V348, DOI 10.1136/bmj.g1799
   Qin ZL, 2020, SAUDI J BIOL SCI, V27, P2485, DOI 10.1016/j.sjbs.2020.05.043
   Salter MW, 2017, NAT MED, V23, P1018, DOI 10.1038/nm.4397
   Schwab JM, 2005, J NEUROIMMUNOL, V163, P185, DOI 10.1016/j.jneuroim.2005.02.016
   Seo SY, 2017, AM J CHINESE MED, V45, P1573, DOI 10.1142/S0192415X17500859
   Shin KM, 2018, DIABETES CARE, V41, pE141, DOI 10.2337/dc18-1254
   Smith PA, 2014, NEUROSCIENCE, V283, P107, DOI 10.1016/j.neuroscience.2014.05.044
   Snyder MJ, 2016, AM FAM PHYSICIAN, V94, P227
   Sun JS, 2015, MOL MED REP, V12, P2677, DOI 10.3892/mmr.2015.3735
   Szkudelski T, 2001, PHYSIOL RES, V50, P537
   Teng YB, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1631-0
   Tozaki-Saitoh H, 2019, GLIA, V67, P729, DOI 10.1002/glia.23570
   Trang T, 2009, J NEUROSCI, V29, P3518, DOI 10.1523/JNEUROSCI.5714-08.2009
   Tsuda M, 2003, NATURE, V424, P778, DOI 10.1038/nature01786
   Tsuda M, 2016, NEUROPHARMACOLOGY, V104, P76, DOI 10.1016/j.neuropharm.2015.08.042
   Tsuda M, 2016, J DIABETES INVEST, V7, P17, DOI 10.1111/jdi.12379
   Tsuda M, 2013, J PHARMACOL SCI, V121, P89, DOI 10.1254/jphs.12R14CP
   Tsuda M, 2009, MOL PAIN, V5, DOI 10.1186/1744-8069-5-28
   Ulmann L, 2008, J NEUROSCI, V28, P11263, DOI 10.1523/JNEUROSCI.2308-08.2008
   Vázquez-Villoldo N, 2014, GLIA, V62, P171, DOI 10.1002/glia.22596
   Wang FX, 2016, SCI REP-UK, V6, DOI 10.1038/srep19396
   Yan Y, 2019, NEUROSCI LETT, V701, P100, DOI 10.1016/j.neulet.2019.02.024
   Zabala A, 2018, EMBO MOL MED, V10, DOI 10.15252/emmm.201708743
   Zhang JQ, 2020, SAUDI J BIOL SCI, V27, P3138, DOI 10.1016/j.sjbs.2020.07.013
   Zhang RY, 2020, ARQ NEURO-PSIQUIAT, V78, P617, DOI [10.1590/0004-282X20200078, 10.1590/0004-282x20200078]
   Zhang Z, 2008, NEUROSCIENCE, V152, P495, DOI 10.1016/j.neuroscience.2007.12.042
   Zhao XM, 2019, PHYSIOL RES, V68, P501, DOI 10.33549/physiolres.934084
   Zhou R, 2018, J PAIN RES, V11, P615, DOI 10.2147/JPR.S154437
NR 55
TC 15
Z9 15
U1 4
U2 21
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1573-9538
EI 1573-9546
J9 PURINERG SIGNAL
JI Purinergic Signal.
PD AUG
PY 2025
VL 21
IS 4
SI SI
BP 533
EP 547
DI 10.1007/s11302-023-09972-9
EA OCT 2023
PG 15
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 7PA8H
UT WOS:001087983000001
PM 37870716
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Dyer, NL
   Surdam, J
   Dusek, JA
AF Dyer, Natalie L.
   Surdam, Jessica
   Dusek, Jeffery A.
TI A Systematic Review of Practiced-Based Research of Complementary and
   Integrative Health Therapies as Provided for Pain Management in Clinical
   Settings: Recommendations for the Future and a Call to Action
SO PAIN MEDICINE
LA English
DT Review
DE Systematic Review; Complementary and Integrative Health; Integrative
   Medicine; Practice-Based Research; Chiropractic; Acupuncture
ID LOW-BACK-PAIN; PATIENT-REPORTED OUTCOMES; MASSAGE THERAPY; CHIROPRACTIC
   MANAGEMENT; CANCER PAIN; CASE SERIES; NECK PAIN; ACUPUNCTURE; VETERANS;
   CARE
AB Objective. The goal of this systematic review was to evaluate practice-based, real-world research of individualized complementary and integrative health (CIH) therapies for pain as provided in CIH outpatient clinics. Methods. A systematic review was conducted on articles in PubMed, Ovid, Cochrane, Web of Science, Scopus, and Embase published through December 2020. The study was listed in the PROSPERO database (CRD42020159193). Major categories of variables extracted included study details and demographics, interventions, and outcomes. Results. The literature search yielded 3,316 records, with 264 assessed for full-text review. Of those, 23 studies (including similar to 8,464 patients) were specific to pain conditions as a main outcome. Studies included chiropractic, acupuncture, multi-modal individualized intervention/programs, physiotherapy, and anthroposophic medicine therapy. Retention rates ranged from 53% to 91%, with studies offering monetary incentives showing the highest retention. The 0-10 numerical rating scale was the most common pain questionnaire (n = 10; 43% of studies), with an average percent improvement across all studies and time points of 32% (range: 18-60%). Conclusions. Findings from this systematic review of practice-based, real-word research indicate that CIH therapies exert positive effects on various pain outcomes. Although all studies reported beneficial impacts on one or more pain outcomes, the heterogeneous nature of the studies limits our overall understanding of CIH as provided in clinical settings. Accordingly, we present numerous recommendations to improve publication reporting and guide future research. Our call to action is that future practice-based CIH research is needed, but it should be more expansive and conducted in association with a CIH scientific society with academic and health care members.
C1 [Dyer, Natalie L.; Surdam, Jessica; Dusek, Jeffery A.] Univ Hosp, Connor Integrat Hlth Network, Cleveland, OH USA.
   [Dusek, Jeffery A.] Case Western Reserve Univ, Dept Family Med & Community Hlth, Cleveland, OH 44106 USA.
C3 University Hospitals of Cleveland; University System of Ohio; Case
   Western Reserve University
RP Dusek, JA (corresponding author), Univ Hosp, Cleveland Med Ctr, Connor Integrat Hlth Network, 11000 Euclid Ave, Cleveland, OH 44106 USA.
EM Jeffery.dusek@UHhospitals.org
OI Dusek, Jeffery/0000-0001-9581-0564
FU Char and Chuck Fowler Family Foundation; National Center for
   Complementary and Integrative Health (NCCIH) of the National Institutes
   of Health (NIH) [AT010598]; National Center for Complementary and
   Integrative Health [R01AT010598] Funding Source: NIH RePORTER
FX Funding was received from the Char and Chuck Fowler Family Foundation
   and Chris and Sara Connor. This research was partially supported via a
   U01 cooperative agreement (AT010598) (NCT NCT04880733) to JAD from the
   National Center for Complementary and Integrative Health (NCCIH) of the
   National Institutes of Health (NIH). The views espoused in this article
   are solely attributable to the authors and not to the NCCIH or NIH.
CR Abrams DI, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-146
   [Anonymous], 2011, REL PAIN AM BLUEPR T, DOI DOI 10.17226/13172
   Askew RL, 2016, J CLIN EPIDEMIOL, V73, P103, DOI 10.1016/j.jclinepi.2015.08.035
   Blanchette MA, 2016, PLOS ONE, V11, DOI DOI 10.1371/journal.pone.0160037
   Blumenthal DM., 2021, Health affairs blog, DOI [10.1377/hblog20170927.062176/full/, DOI 10.1080/00141844.2021]
   Burke JR, 2014, J CHIROPR MED, V13, P168, DOI 10.1016/j.jcm.2014.07.007
   Chaibi A, 2014, J HEADACHE PAIN, V15, DOI 10.1186/1129-2377-15-67
   Chen H, 2013, PANCREATOLOGY, V13, P594, DOI 10.1016/j.pan.2013.10.007
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Chou R, 2017, ANN INTERN MED, V166, P493, DOI 10.7326/M16-2459
   Clarke TC, 2018, J ALTERN COMPLEM MED, V24, P139, DOI 10.1089/acm.2016.0182
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   Cohen AT, 2015, EUR HEART J SUPPL, V17, pD2, DOI 10.1093/eurheartj/suv035
   Corcoran KL, 2017, J MANIP PHYSIOL THER, V40, P573, DOI 10.1016/j.jmpt.2017.07.001
   Crawford C, 2016, PAIN MED, V17, P1353, DOI 10.1093/pm/pnw099
   Dowell Deborah, 2016, JAMA, V315, P1624, DOI [10.15585/mmwr.rr6501e1, 10.1001/jama.2016.1464]
   Dunn AS, 2011, J REHABIL RES DEV, V48, P927, DOI 10.1682/JRRD.2010.10.0202
   Dunn AS, 2011, J MANIP PHYSIOL THER, V34, P533, DOI 10.1016/j.jmpt.2011.08.009
   Dusek JA, 2018, COMPLEMENT THER MED, V37, P43, DOI 10.1016/j.ctim.2018.01.012
   Dusek JA, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1025-0
   Elwy AR, 2020, MED CARE, V58, pS125, DOI 10.1097/MLR.0000000000001357
   Elwy AR, 2014, MED CARE, V52, pS70, DOI 10.1097/MLR.0000000000000228
   Ernst E, 2003, J PAIN, V4, P417, DOI 10.1067/S1526-5900(03)00735-1
   Ferguson CJ, 2009, PROF PSYCHOL-RES PR, V40, P532, DOI 10.1037/a0015808
   Garcia MK, 2018, INTEGR CANCER THER, V17, P148, DOI 10.1177/1534735416685403
   Gedin F, 2019, J BODYW MOV THER, V23, P241, DOI 10.1016/j.jbmt.2018.02.012
   Gentile D, 2018, J ALTERN COMPLEM MED, V24, P968, DOI 10.1089/acm.2018.0192
   Gibson CJ, 2020, PAIN MED, V21, P1977, DOI 10.1093/pm/pnaa003
   Goertz CM, 2013, SPINE, V38, P627, DOI 10.1097/BRS.0b013e31827733e7
   Goh MR, 2010, PROC SINGAP HEALTHC, V19, P175, DOI 10.1177/201010581001900302
   GREEN SB, 1991, MULTIVAR BEHAV RES, V26, P499, DOI 10.1207/s15327906mbr2603_7
   Haas M, 2005, J MANIP PHYSIOL THER, V28, P555, DOI 10.1016/j.jmpt.2005.08.006
   Hamre Harald J, 2009, J Pain Res, V2, P75
   Hay SI, 2017, LANCET, V389, pE1
   Hays RD, 2019, SPINE, V44, P647, DOI 10.1097/BRS.0000000000002902
   JAESCHKE R, 1989, CONTROL CLIN TRIALS, V10, P407, DOI 10.1016/0197-2456(89)90005-6
   Johnson JR, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-486
   Johnson Jill R., 2014, Journal of the National Cancer Institute Monographs, P330, DOI 10.1093/jncimonographs/lgu030
   Kong LJ, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/613279
   Kopansky-Giles D., 2010, Journal of Alternative Medicine Research, V2, P61
   Kumar S, 2013, INT J GEN MED, V6, P733, DOI 10.2147/IJGM.S50243
   Lakens D., 2013, FRONT PSYCHOL, V4, P863, DOI [DOI 10.3389/fpsyg.2013.00863, 10.3389/fpsyg.2013.00004]
   Lee H, 2019, COMPLEMENT THER MED, V43, P7, DOI 10.1016/j.ctim.2018.12.023
   Lee MK, 2020, J PATIENT-REP OUTCOM, V4, DOI 10.1186/s41687-020-00271-0
   Lee SH, 2015, INTEGR CANCER THER, V14, P297, DOI 10.1177/1534735415572885
   Lisi AJ, 2010, J REHABIL RES DEV, V47, P1, DOI 10.1682/JRRD.2009.07.0095
   Lopez G, 2018, J CANCER, V9, P3613, DOI 10.7150/jca.26527
   Maiers M, 2008, J ALTERN COMPLEM MED, V14, P1083, DOI 10.1089/acm.2008.0225
   McGlothlin AE, 2014, JAMA-J AM MED ASSOC, V312, P1342, DOI 10.1001/jama.2014.13128
   Miller KR, 2019, AM J HOSP PALLIAT ME, V36, P326, DOI 10.1177/1049909118804464
   Murphy DR, 2009, J MANIP PHYSIOL THER, V32, P723, DOI 10.1016/j.jmpt.2009.10.007
   Murthy VH, 2016, NEW ENGL J MED, V375, P2413, DOI 10.1056/NEJMp1612578
   National Academies of Sciences Engineering and Medicine, 2017, PAIN MAN OP EP BAL S
   National Center for Complementary and Integrative Health, 2020, WHY STUD COMPL HLTH
   National Institutes of Health, 2019, NAT PAIN STRAT COMPR
   Nelson NL, 2017, AM J PHYS MED REHAB, V96, P665, DOI 10.1097/PHM.0000000000000712
   Newell D, 2007, CLIN CHIROPR, V10, P179, DOI DOI 10.1016/J.CLCH.2007.10.003
   Niemtzow RC, 2008, MED ACUPUNCT, V20, P255, DOI 10.1089/acu.2008.0594
   Nyiendo J, 2000, J MANIP PHYSIOL THER, V23, P239
   Okuse K, 2007, INT J BIOCHEM CELL B, V39, P490, DOI 10.1016/j.biocel.2006.11.016
   Olsen MF, 2017, BMC MED, V15, DOI 10.1186/s12916-016-0775-3
   Pina LTS, 2017, EXPERT OPIN THER PAT, V27, P787, DOI 10.1080/13543776.2017.1297425
   Posadzki P, 2012, COMPLEMENT THER MED, V20, P232, DOI 10.1016/j.ctim.2011.12.001
   Qaseem A, 2017, ANN INTERN MED, V166, P514, DOI 10.7326/M16-2367
   Schliesser JS., 2003, Journal of manipulative and physiological therapeutics, V26, P592
   Schoomaker E, 2014, PAIN MED, V15, pS4, DOI 10.1111/pme.12385
   Secor ER Jr, 2004, J ALTERN COMPLEM MED, V10, P506, DOI 10.1089/1075553041323704
   Thompson LMA, 2015, J ACUPUNCT MERIDIAN, V8, P127, DOI 10.1016/j.jams.2015.04.002
   Tick H, 2018, EXPLORE-NY, V14, P177, DOI 10.1016/j.explore.2018.02.001
   *US FDA, 2017, FDA ED BLUEPR HLTH C
   Veterans Affairs and Department of Defense, 2017, CLIN PRACTICE GUIDEL
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Walker BF, 2013, SPINE, V38, P2071, DOI 10.1097/01.brs.0000435032.73187.c7
   Wayne PM, 2018, J ALTERN COMPLEM MED, V24, P781, DOI 10.1089/acm.2018.0002
   Westfall JM, 2007, JAMA-J AM MED ASSOC, V297, P403, DOI 10.1001/jama.297.4.403
   Wirth B, 2019, CHIROPR MAN THER, V27, DOI 10.1186/s12998-018-0225-8
   Yeganeh M, 2017, COMPLEMENT THER CLIN, V27, P11, DOI 10.1016/j.ctcp.2016.11.012
   Yuan QL, 2016, SCI REP-UK, V6, DOI 10.1038/srep30675
NR 79
TC 16
Z9 17
U1 1
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD JAN
PY 2022
VL 23
IS 1
BP 189
EP 210
DI 10.1093/pm/pnab151
EA MAY 2021
PG 22
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anesthesiology; General & Internal Medicine
GA YI1JM
UT WOS:000743612500017
PM 34009391
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Hansen, L
   Leo, MC
   Chang, MF
   Zucker, BL
   Sasaki, A
AF Hansen, Lissi
   Leo, Michael C.
   Chang, Michael F.
   Zucker, Betsy L.
   Sasaki, Anna
TI Pain and Self-Care Behaviours in Adult Patients with End-Stage Liver
   Disease: A longitudinal description
SO JOURNAL OF PALLIATIVE CARE
LA English
DT Article
DE palliative care; survival time; simple prognostic scores
ID QUALITY-OF-LIFE; INTEGRATING PALLIATIVE CARE; PSYCHOLOGICAL DISTRESS;
   CANCER PAIN; TRANSPLANT; MODEL; ACUPUNCTURE; MEDICATIONS; CIRRHOSIS;
   SEVERITY
AB This prospective descriptive study investigated pain characteristics in 20 outpatients with end-stage liver disease (ESLD) who were approaching the end of life, described variability in pain between and within patients, and described the pharmacological and nonpharmacological pain management strategies used. The instruments we utilized were the Brief Pain Inventory (BPI) and the self-care behaviour (SCB) log for pain. Data were collected once a month over a six-month period. BPI severity of, and interference from pain mean scores ranged from 5.52 to 6.03 and 5.36 to 6.64, respectively. The top three pain-relieving behaviours reported by patients were "taking pain medication," "taking a nap," and "asking for help." Pain medication intake differed between patients who were pursuing a liver transplant and those who were not eligible for one. If we are to effectively improve care for ESLD patients, it is essential that we understand the ways in which these patients experience pain and the pain management strategies they employ.
C1 [Hansen, Lissi] Oregon Hlth & Sci Univ, Sch Nursing, SN ORD, Portland, OR 97239 USA.
   [Leo, Michael C.] Kaiser Permanente, Ctr Hlth Res, Portland, OR USA.
   [Chang, Michael F.; Zucker, Betsy L.; Sasaki, Anna] Portland VA Med Ctr, Portland, OR USA.
   [Sasaki, Anna] Oregon Hlth & Sci Univ, Portland, OR 97239 USA.
C3 Oregon Health & Science University; Kaiser Permanente; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Portland VA
   Medical Center; Oregon Health & Science University
RP Hansen, L (corresponding author), Oregon Hlth & Sci Univ, Sch Nursing, SN ORD, 3455 SW US Vet Hosp Rd, Portland, OR 97239 USA.
EM hansenli@ohsu.edu
FU National Institute of Nursing Research, National Institutes of Health
   (NIH) [R03 NR010614]
FX Special thanks go to the patients who participated in the study and to
   Dr. Christine A. Miaskowski at the University of California, San
   Francisco, for giving us permission to use the SCB log for pain. This
   study was supported by research grant R03 NR010614 from the National
   Institute of Nursing Research, National Institutes of Health (NIH).
CR Pérez-San-Gregorio MA, 2013, J CLIN PSYCHOL MED S, V20, P97, DOI 10.1007/s10880-012-9309-0
   [Anonymous], 2012, NATL VITAL STAT REPO
   [Anonymous], 2012, NHPCO Facts and Figures: Hospice Care in America
   Antaki F, 2007, J CLIN GASTROENTEROL, V41, P412, DOI 10.1097/01.mcg.0000225594.01201.9b
   Boyd K, 2012, HEPATOLOGY, V55, P1650, DOI 10.1002/hep.25621
   Casarett DJ, 2003, J PAIN SYMPTOM MANAG, V25, pS6, DOI 10.1016/S0885-3924(03)00097-6
   Chandok N, 2010, MAYO CLIN PROC, V85, P451, DOI 10.4065/mcp.2009.0534
   Chang VT, 2002, J PAIN SYMPTOM MANAG, V24, P494, DOI 10.1016/S0885-3924(02)00516-X
   Cowan DT, 2005, PAIN MED, V6, P113, DOI 10.1111/j.1526-4637.2005.05020.x
   DAUT RL, 1983, PAIN, V17, P197, DOI 10.1016/0304-3959(83)90143-4
   Davis H, 1998, J PSYCHOSOM RES, V44, P547, DOI 10.1016/S0022-3999(97)00288-2
   De Bona M, 2000, J HEPATOL, V33, P609, DOI 10.1034/j.1600-0641.2000.033004609.x
   Desbiens NA, 2000, J AM GERIATR SOC, V48, pS183, DOI 10.1111/j.1532-5415.2000.tb03130.x
   Desbiens NA, 1996, CRIT CARE MED, V24, P1953, DOI 10.1097/00003246-199612000-00005
   El-Jawahri Areej, 2011, J Support Oncol, V9, P87
   Ersek M, 1999, CANCER PRACT, V7, P226, DOI 10.1046/j.1523-5394.1999.75007.x
   Hansen L, GASTROENTER IN PRESS
   Hansen L, 2010, NURS CLIN N AM, V45, P411, DOI 10.1016/j.cnur.2010.03.005
   Health Resources and Services Administration, 2012, OPTN SRTR 2011 ANN D
   Higginson IJ, 2010, CANCER J, V16, P423, DOI 10.1097/PPO.0b013e3181f684e5
   Hope AA, 2011, J PALLIAT CARE, V27, P20, DOI 10.1177/082585971102700105
   Kamath PS, 2003, LIVER TRANSPLANT, V9, P19, DOI 10.1053/jlts.2003.50031
   Kamath PS, 2001, HEPATOLOGY, V33, P464, DOI 10.1053/jhep.2001.22172
   Kaplan R, 2000, J PAIN SYMPTOM MANAG, V19, P265, DOI 10.1016/S0885-3924(00)00117-2
   KNAUS WA, 1995, JAMA-J AM MED ASSOC, V274, P1591, DOI 10.1001/jama.1995.03530200027032
   Larson AM, 2006, JAMA-J AM MED ASSOC, V295, P2168, DOI 10.1001/jama.295.18.2168
   Lu WD, 2013, CURR PAIN HEADACHE R, V17, DOI 10.1007/s11916-013-0321-3
   Lynn J, 1997, ANN INTERN MED, V126, P97, DOI 10.7326/0003-4819-126-2-199701150-00001
   Madan A, 2012, PROG TRANSPLANT, V22, P379, DOI 10.7182/pit2012535
   McMillan SC, 2011, CANCER NURS, V34, P89, DOI 10.1097/NCC.0b013e3181f70aee
   Medici V, 2008, LIVER TRANSPLANT, V14, P1100, DOI 10.1002/lt.21398
   National Institutes of Health (NIH) US Department of Health and Human Services, 2012, HUM SUBJ PROT INCL W
   Office of Integrity Oregon Health and Science University (OHSU), 2007, GUID HUM SUBJ RES DE
   Oregon Health and Science University (OHSU) Portland Veterans Affairs Medical Center Combined Liver Transplant Program, RES LIF LIV TRANSPL
   Ratcliffe J, 2002, LIVER TRANSPLANT, V8, P263, DOI 10.1053/jlts.2002.31345
   Rhee C, 2007, J PALLIAT MED, V10, P677, DOI 10.1089/jpm.2006.0246
   Riley TR III, 2003, DIGEST DIS SCI, V48, P1914, DOI 10.1023/A:1026149732756
   Roth K, 2000, J AM GERIATR SOC, V48, pS122
   Schieffer BM, 2005, J PAIN, V6, P620, DOI 10.1016/j.jpain.2005.04.004
   Simone Charles B 2nd, 2012, J Opioid Manag, V8, P9
   Tan G, 2004, J PAIN, V5, P133, DOI 10.1016/j.jpain.2003.12.005
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Wang XS, 1999, CANCER, V86, P1848, DOI 10.1002/(SICI)1097-0142(19991101)86:9<1848::AID-CNCR29>3.3.CO;2-D
   Younossi ZM, 2001, AM J GASTROENTEROL, V96, P2199, DOI 10.1016/S0002-9270(01)02519-9
NR 44
TC 18
Z9 22
U1 0
U2 16
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0825-8597
EI 2369-5293
J9 J PALLIAT CARE
JI J. Palliative Care
PD SPR
PY 2014
VL 30
IS 1
BP 32
EP 40
DI 10.1177/082585971403000105
PG 9
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA AE2HW
UT WOS:000333794900005
PM 24826441
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Cao, Y
   Bai, ZQ
AF Cao, Yong
   Bai, Zhiqiang
TI Evaluation of acupuncture on pain intensity and sleep quality in
   patients with neuropathic pain following spinal cord injury
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Spinal cord injury; neuropathic pain; acupuncture; pharmacotherapy;
   effect modification
AB Objective: To assess the efficacy of incorporating acupuncture into standard pharmacotherapy for neuropathic pain following spinal cord injury (SCI-NP) and investigate the potential influence of age and disease duration on this effect. Methods: We conducted a retrospective review of 312 patients with SCI-NP who were treated at Northwest University First Hospital from March 2022 to August 2024. According to the hospital information system, patients either received standard pharmacotherapy alone (control) or pharmacotherapy in conjunction with acupuncture (study). The duration of both regimens was four weeks. The main outcomes were changes in the Pain Rating Index (PRI), the Visual Analogue Scale (VAS), and the Present Pain Intensity (PPI). Secondary outcomes included sleep quality (Pittsburgh Sleep Quality Index, PSQI), inflammatory markers (Interleukin-1 beta, Interleukin-6, Tumor Necrosis Factor-alpha), immune indices (Immunoglobulin A, Immunoglobulin G), and adverse events. Results: The combination resulted in more significant decreases in PRI, VAS, and PPI, as well as more notable enhancements in PSQI, inflammatory markers, and immunoglobulin levels (all P<0.0001), compared to pharmacotherapy alone. The rates of adverse events were comparable between groups (P>0.05). Age-by-duration analysis revealed that in patients aged 40-50 years, an extended disease duration correlated with a diminished probability of pain improvement (P=0.018); conversely, no definitive association was found in individuals over 50 years (P=0.694). Conclusion: Adding acupuncture to conventional pharmacotherapy reduced pain, improved sleep quality, and shifted inflammatory and immune indices in a favorable direction, without an increase in adverse events. Treatment response varied by patient profile: among those aged 40 to 50 years, longer disease duration was linked to a lower likelihood of pain improvement, while no clear duration effect was seen in older patients.
C1 [Cao, Yong; Bai, Zhiqiang] Northwest Univ, Dept Rehabil, Hosp 1, 512 Xianning East Rd, Xian 710043, Shaanxi, Peoples R China.
C3 Northwest University Xi'an
RP Bai, ZQ (corresponding author), Northwest Univ, Dept Rehabil, Hosp 1, 512 Xianning East Rd, Xian 710043, Shaanxi, Peoples R China.
EM bai680320@163.com
CR Anjum A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207533
   Chen T, 2021, PAIN THER, V10, P1497, DOI 10.1007/s40122-021-00302-8
   Chen Y, 2023, FRONT NEUROL, V14, DOI 10.3389/fneur.2023.1093849
   Dworkin RH, 2005, PAIN, V113, P9, DOI 10.1016/j.pain.2004.09.012
   Eli I, 2021, NEUROL CLIN, V39, P471, DOI 10.1016/j.ncl.2021.02.004
   Eller OC, 2022, FRONT PAIN RES, V3, DOI 10.3389/fpain.2022.991736
   Feng ZT, 2023, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.1076993
   Ge SY, 2025, NEUROL SCI, V46, P3547, DOI 10.1007/s10072-025-08120-y
   He KL, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/6297484
   Irwin MR, 2015, ANNU REV PSYCHOL, V66, P143, DOI 10.1146/annurev-psych-010213-115205
   Kannan P, 2022, THER ADV CHRONIC DIS, V13, DOI 10.1177/20406223221078672
   Khosravaninezhad Y, 2025, EXPLORE-NY, V21, DOI 10.1016/j.explore.2025.103192
   Kohno K, 2022, SCIENCE, V376, P86, DOI 10.1126/science.abf6805
   Kui WY, 2025, J PAIN RES, V18, P1115, DOI 10.2147/JPR.S506569
   Li XM, 2025, FRONT CELL NEUROSCI, V19, DOI 10.3389/fncel.2025.1547524
   Liu CY, 2019, TRIALS, V20, DOI 10.1186/s13063-019-3964-5
   Liu LY, 2024, J INTEGR MED-JIM, V22, P32, DOI 10.1016/j.joim.2024.01.005
   Lordache SD, 2023, ISR MED ASSOC J, V25, P286
   Ma X, 2022, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.940343
   Norrbrink C, 2011, ACUPUNCT MED, V29, P108, DOI 10.1136/aim.2010.003269
   Shi GX, 2025, J PAIN RES, V18, P663, DOI 10.2147/JPR.S486812
   Sun LT, 2021, NEURAL PLAST, V2021, DOI 10.1155/2021/5607898
   Wang N, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1092402
   Widerström-Noga E, 2023, DRUGS, V83, P1001, DOI 10.1007/s40265-023-01903-7
   Wu JM, 2024, FRONT NEUROSCI-SWITZ, V18, DOI 10.3389/fnins.2024.1346635
   Wu WD, 2025, FRONT PHARMACOL, V16, DOI 10.3389/fphar.2025.1588284
   Yang Y, 2022, SPINAL CORD, V60, P375, DOI 10.1038/s41393-022-00776-z
   Ye Y, 2024, CELL MOL NEUROBIOL, V44, DOI 10.1007/s10571-024-01517-x
   Yuan M, 2022, FRONT AGING NEUROSCI, V14, DOI 10.3389/fnagi.2022.913881
   Zhao HF, 2024, COMB CHEM HIGH T SCR, V27, P2951, DOI 10.2174/0113862073265007231108050338
   Zheng JY, 2024, J INTEGR MED-JIM, V22, P445, DOI 10.1016/j.joim.2024.06.004
   Zitser J, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0270095
NR 32
TC 0
Z9 0
U1 1
U2 1
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2025
VL 17
IS 12
BP 9242
EP 9258
DI 10.62347/EKQG6497
PG 17
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA AK5YK
UT WOS:001650339800001
OA Bronze
DA 2026-01-16
ER

PT J
AU Song, HJ
   Seo, HJ
   Lee, H
   Son, H
   Choi, SM
   Lee, S
AF Song, Hyun Jin
   Seo, Hyun-Ju
   Lee, Heeyoung
   Son, Heejeong
   Choi, Sun Mi
   Lee, Sanghun
TI Effect of self-acupressure for symptom management: A systematic review
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Acupressure; Self-administration; Signs and Symptoms
ID EFFICACY; QUALITY; POINT
AB Objectives: To assess the efficacy and safety of self-administered acupressure to alleviate symptoms of various health problems, including allergic disease, cancer, respiratory disease, dysmenorrhea, perceived stress, insomnia, and sleep disturbances.
   Methods: We searched core, Korean, Chinese, and Japanese databases, including Ovid-MEDLINE, Ovid-EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), the Cumulative Index to Nursing and Allied Health Literature (CINAHL), six representative electronic Korean medical databases, China National Knowledge Infrastructure (CNKI), and Japan Science and Technology Information Aggregator (J-STAGE). We included randomized controlled trials (RCTs) and quasi-RCTs that examined disease-specific effects or symptom relief, adverse reactions, and quality-of-life (QOL) for self-administered acupressure. Data collection and assessment of the methodological quality of the included studies were conducted by two independent reviewers.
   Results: Eight RCTs and two quasi-RCTs showed positive effects and safety of self-acupressure therapy in clinically diverse populations. Quality assessment revealed moderate quality for the RCTs, with 50% or more of the trials assessed as presenting a low risk of bias in seven domains. All of the selected 10 studies reported positive effects for primary outcomes of self-acupressure therapy for symptom management, including significant improvements in symptom scores in allergic disease, nausea and vomiting in cancer, symptom scores in respiratory disease, pain symptoms in dysmenorrhea, and stress/fatigue scores and sleep disturbances in healthy people.
   Conclusions: Our findings suggest that self-administered acupressure shows promise to alleviate the symptoms of various health problems. Therefore, further research with larger samples and methodologically well-designed RCTs is required to establish the efficacy of self-administered acupressure. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Song, Hyun Jin] Sungkyunkwan Univ, Sch Pharm, Suwon, South Korea.
   [Seo, Hyun-Ju] Chosun Univ, Coll Med, Dept Nursing, Kwangju 501759, South Korea.
   [Lee, Heeyoung] Seoul Natl Univ, Bundang Hosp, Publ Hlth Med Serv, Songnam, South Korea.
   [Son, Heejeong] Seoul Natl Univ, Grad Sch Publ Hlth, Seoul, South Korea.
   [Choi, Sun Mi; Lee, Sanghun] Korea Inst Oriental Med, Taejon, South Korea.
C3 Sungkyunkwan University (SKKU); Chosun University; Seoul National
   University (SNU); Seoul National University (SNU); Korea Institute of
   Oriental Medicine (KIOM)
RP Seo, HJ (corresponding author), Chosun Univ, Coll Med, Dept Nursing, 309 Pilmum Daero, Kwangju 501759, South Korea.
EM shj5th@korea.ac.kr
RI lee, hy/GRS-0797-2022; Seo, Hyun-Ju/KVZ-1630-2024
OI Seo, Hyun-Ju/0000-0001-9019-1135
FU Korea Institute of Oriental Medicine (KIOM) in South Korea [K12210]
FX This study was performed as part of the Infrastructure Development
   Project for Traditional Knowledge-based Remedy (K12210) funded by the
   Korea Institute of Oriental Medicine (KIOM) in South Korea. The results
   of this project were subjected to the KIOM appraisal process. No other
   sources of funding were used to assist in the preparation of this
   article.
CR Bazarganipour F, 2010, INT J GYNECOL OBSTET, V111, P105, DOI 10.1016/j.ijgo.2010.04.030
   Beal MW, 1999, J NURSE-MIDWIFERY, V44, P217, DOI 10.1016/S0091-2182(99)00054-3
   Chao Hui-Lin, 2013, Oncol Nurs Forum, V40, pE61, DOI 10.1188/13.ONF.E61-E68
   Chen HM, 2004, J ADV NURS, V48, P380, DOI 10.1111/j.1365-2648.2004.03236.x
   Dibble SL, 2007, ONCOL NURS FORUM, V34, P815, DOI 10.1188/07.ONF.813-820
   Fritz DJ, 2013, J AM BOARD FAM MED, V26, P61, DOI 10.3122/jabfm.2013.01.120157
   Higgins J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000049
   Honda Y., 2012, OPEN J MED PSYCHOL, V01, P20, DOI [10.4236/ojmp.2012.13004, DOI 10.4236/OJMP.2012.13004]
   Jiang HR, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/169692
   Kim SY, 2013, J CLIN EPIDEMIOL, V66, P408, DOI 10.1016/j.jclinepi.2012.09.016
   Kim Wonill, 2004, Korean Journal of Acupuncture, V21, P81
   Lee EJ, 2011, J PAIN SYMPTOM MANAG, V42, P589, DOI 10.1016/j.jpainsymman.2011.01.007
   Lee JS, 2011, INT J NEUROSCI, V121, P409, DOI 10.3109/00207454.2011.570465
   Lee KC, 2012, ACUPUNCT MED, V30, P8, DOI 10.1136/acupmed-2011-010088
   Lu MJ, 2013, NURS RES, V62, P130, DOI 10.1097/NNR.0b013e3182781524
   Maa S H, 1997, J Cardiopulm Rehabil, V17, P268, DOI 10.1097/00008483-199707000-00008
   Maa SH, 2003, J ALTERN COMPLEM MED, V9, P659, DOI 10.1089/107555303322524517
   Maa SH, 2007, J CLIN NURS, V16, P794, DOI 10.1111/j.1365-2702.2005.01515.x
   National Cancer Institute, 2007, AC
   Noroozinia Heydar, 2013, Acta Med Iran, V51, P163
   Rerksuppaphol Lakkana, 2012, J Med Assoc Thai, V95 Suppl 12, pS32
   Robinson N, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-88
   Shin YH, 2004, CANCER NURS, V27, P267, DOI 10.1097/00002820-200407000-00002
   Smith CA, 2011, COCHRANE DB SYST REV, V7
   Wong C L, 2010, Complement Ther Clin Pract, V16, P64, DOI 10.1016/j.ctcp.2009.10.002
   Wu HS, 2004, J ADV NURS, V45, P252, DOI 10.1046/j.1365-2648.2003.02886.x
   Xue CC, 2011, ANN ALLERG ASTHMA IM, V106, P168, DOI 10.1016/j.anai.2010.11.006
   Yang MH, 2007, J CLIN NURS, V16, P308, DOI 10.1111/j.1365-2702.2006.01428.x
   Yeh CH, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/196978
   Yeung WF, 2012, SLEEP MED, V13, P971, DOI 10.1016/j.sleep.2012.06.003
   Yip YB, 2004, COMPLEMENT THER MED, V12, P28, DOI 10.1016/j.ctim.2003.12.003
   Zhang CS, 2010, CLIN OTOLARYNGOL, V35, P6, DOI 10.1111/j.1749-4486.2009.02067.x
NR 32
TC 79
Z9 86
U1 0
U2 32
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD FEB
PY 2015
VL 23
IS 1
BP 68
EP 78
DI 10.1016/j.ctim.2014.11.002
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA CB6II
UT WOS:000349730300010
PM 25637155
DA 2026-01-16
ER

PT J
AU Harorani, M
   Salehi, M
   Shahrodi, M
   Rafiei, F
AF Harorani, Mehdi
   Salehi, Mehdi
   Shahrodi, Mohadese
   Rafiei, Fatemeh
TI Effect of localized acupressure massage on anxiety during chemotherapy
   in patients with breast cancer: A single-blind randomized clinical trial
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Anxiety; Breast cancer; Chemotherapy; Acupressure massage
ID ALTERNATIVE MEDICINE; SHIATSU MASSAGE; HAND MASSAGE; THERAPY;
   COMPLEMENTARY; PAIN; RELAXATION; DEPRESSION; SURGERY; WOMEN
AB Introduction: Patients with breast cancer are prone to numerous physical and mental complications due to their disease and treatments . Anxiety is acommon psychological complication observed in such patients. This study aimed to investigate the effect of acupressure massage on anxiety during chemotherapy in patients with breast cancer.Methods: This single-blind randomized clinical trial study was conducted on 70 cancer patients undergoing chemotherapy. The intervention group (n = 35) received acupressure massage in three 5 min periods with 2 min breaks between them. However, in the control group (n = 35), the same area was only touched for a while in a similar way to that performed in the intervention group. Patients' anxiety was measured before and after the intervention using the Spielberger State-Trait Anxiety Inventory. The collected data from both groups were analyzed in SPSS software (version16).Results: The difference between patients' anxiety was significant after the intervention in the two groups. The level of anxiety among patients in the experimental group was significantly reduced after the intervention, compared to the control group (P=0.0001).Conclusion: Due to the simplicity and low cost of massage, it is recommended that this method be adopted to reduce patients' anxiety along with other treatments. Trial registration: IRCT20151002024290N2).
C1 [Harorani, Mehdi] Arak Univ Med Sci, Shazand Sch Nursing, Dept Nursing, Arak, Iran.
   [Harorani, Mehdi; Salehi, Mehdi] Arak Univ Med Sci, Tradit & Complementary Med Res Ctr TCMRC, Arak, Iran.
   [Shahrodi, Mohadese] Islamic Azad Univ, Gonbad Kavoos branch, Gonbad Kavous, Iran.
   [Rafiei, Fatemeh] Univ Tehran Med Sci, Sci Res Ctr, Sch Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
C3 Islamic Azad University; Tehran University of Medical Sciences
RP Harorani, M (corresponding author), Arak Univ Med Sci, Shazand Sch Nursing, Dept Nursing, Arak, Iran.
EM m.harorani@yahoo.com
RI harorani, mehdi/L-1306-2018; salehi, mehdi/AAY-8266-2021; Rafiei,
   Fatemeh/AFK-0185-2022
OI harorani, mehdi/0000-0002-9467-5986; 
FU Arak University of Medical Sciences, Arak, Iran;  [3358]
FX Financial support This study was supported by Arak University of Medical
   Sciences, Arak, Iran (No: 3358) .
CR Ardabili FM, 2015, WORLD J PLAST SURG, V4, P36
   Bieling PJ, 1998, BEHAV RES THER, V36, P777, DOI 10.1016/S0005-7967(98)00023-0
   Chen X, 2021, SUPPORT CARE CANCER, V29, P4773, DOI 10.1007/s00520-021-05994-4
   Dreyer NE, 2015, COMPLEMENT THER CLIN, V21, P154, DOI 10.1016/j.ctcp.2015.06.004
   Erzincanli S, 2021, PAIN MANAG NURS, V22, P356, DOI 10.1016/j.pmn.2020.12.005
   Farahani MF, 2020, J PERIANESTH NURS, V35, P277, DOI 10.1016/j.jopan.2019.10.010
   Fazlollah A, 2021, COMPLEMENT THER MED, V60, DOI 10.1016/j.ctim.2021.102738
   Gunnarsdottir TJ, 2007, J CLIN NURS, V16, P777, DOI 10.1111/j.1365-2702.2006.01634.x
   Harorani M, 2021, HEART LUNG, V50, P893, DOI 10.1016/j.hrtlng.2021.07.013
   Harorani M, 2020, COMPLEMENT THER MED, V50, DOI 10.1016/j.ctim.2020.102344
   Harorani M, 2020, SUPPORT CARE CANCER, V28, P405, DOI 10.1007/s00520-019-05025-3
   Hattan J, 2002, J ADV NURS, V37, P199, DOI 10.1046/j.1365-2648.2002.02083.x
   Honda K, 2005, PREV MED, V40, P46, DOI 10.1016/j.ypmed.2004.05.001
   Jafarimanesh H, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420967084
   Kissane DW, 2003, PSYCHO-ONCOLOGY, V12, P532, DOI 10.1002/pon.683
   Kobayashi D, 2019, COMPLEMENT THER MED, V45, P33, DOI 10.1016/j.ctim.2019.05.019
   Lanza G, 2018, COMPLEMENT THER MED, V38, P74, DOI 10.1016/j.ctim.2018.04.013
   Lei SY, 2021, CANCER COMMUN, V41, P1183, DOI 10.1002/cac2.12207
   Li J, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-041588
   Li ZH, 2021, EXPLORE-NY, V17, P410, DOI 10.1016/j.explore.2020.08.016
   Long AF, 2008, J ALTERN COMPLEM MED, V14, P921, DOI 10.1089/acm.2008.0085
   Long AF, 2009, COMPLEMENT THER MED, V17, P168, DOI 10.1016/j.ctim.2008.09.004
   Maajani K, 2019, CLIN BREAST CANCER, V19, P165, DOI 10.1016/j.clbc.2019.01.006
   Mirtajadini H, 2016, Mil Caring Sci, V3, P27
   Moyer CA, 2011, J BODYW MOV THER, V15, P3, DOI 10.1016/j.jbmt.2010.06.001
   Nakamura ZM, 2021, ONCOLOGIST, V26, P147, DOI 10.1002/onco.13528
   Pelekasis P, 2016, INTEGR CANCER THER, V15, P165, DOI 10.1177/1534735415598225
   Sebri V, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.611954
   Siegel RL, 2020, CA-CANCER J CLIN, V70, P7, DOI 10.3322/caac.21590
   Spilioti E., 2017, Int J Caring Sci, V10, P1465
   Thomson P, 2014, COMPLEMENT THER CLIN, V20, P302, DOI 10.1016/j.ctcp.2014.09.004
   Tsiormpatzis S, 2019, EUR J INTEGR MED, V32, DOI 10.1016/j.eujim.2019.101006
   Villani V, 2017, NEUROL SCI, V38, P999, DOI 10.1007/s10072-017-2888-7
   Williams AM, 2021, BREAST CANCER RES TR, V187, P275, DOI 10.1007/s10549-020-06067-6
   Yoon HG, 2019, APPL NURS RES, V48, P45, DOI 10.1016/j.apnr.2019.05.009
   Zhang JY, 2018, CANCER NURS, V41, P62, DOI 10.1097/NCC.0000000000000451
   Zhao HH, 2022, J ADV NURS, V78, P750, DOI 10.1111/jan.15004
NR 37
TC 1
Z9 1
U1 1
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD JAN
PY 2023
VL 57
AR 102209
DI 10.1016/j.eujim.2022.102209
EA DEC 2022
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 7M0HK
UT WOS:000906337900001
DA 2026-01-16
ER

PT J
AU Lu, WD
   Giobbie-Hurder, A
   Freedman, RA
   Shin, IH
   Lin, NU
   Partridge, AH
   Rosenthal, DS
   Ligibel, JA
AF Lu Weidong
   Giobbie-Hurder, Anita
   Freedman, Rachel A.
   Shin, Im Hee
   Lin, Nancy U.
   Partridge, Ann H.
   Rosenthal, David S.
   Ligibel, Jennifer A.
TI Acupuncture for Chemotherapy-Induced Peripheral Neuropathy in Breast
   Cancer Survivors: A Randomized Controlled Pilot Trial
SO ONCOLOGIST
LA English
DT Article
DE Acupuncture; Chemotherapy-induced peripheral neuropathy; Breast cancer
   survivors; Quality of life; Taxane
ID QUALITY-OF-LIFE; FUNCTIONAL ASSESSMENT; WEEKLY PACLITAXEL;
   CLINICAL-TRIALS; PREVALENCE; ONCOLOGY; WOMEN; MANAGEMENT; SYMPTOMS;
   THERAPY
AB Background Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating long-term side effects in breast cancer survivors. We conducted a randomized controlled pilot trial to assess the feasibility, safety, and effects of an acupuncture intervention on CIPN in this population.
   Patients and Methods Women with stage I-III breast cancer with grade 1 or higher CIPN after taxane-containing adjuvant chemotherapy were randomized 1:1 to an immediate acupuncture (IA) arm or to a waitlist control group (CG). Participants in the IA arm received 18 sessions of acupuncture over 8 weeks, then received no additional acupuncture. Patients in the CG arm received usual care over 8 weeks, followed by nine sessions of acupuncture over 8 weeks. Measures including Patient Neurotoxicity Questionnaire (PNQ), Functional Assessment of Cancer Therapy-Neurotoxicity subscale (FACT-NTX), and Brief Pain Inventory-short form (BPI-SF) were collected at baseline and at 4, 8, and 16 weeks after enrollment.
   Results Forty women (median age, 54) were enrolled (20 to IA and 20 to CG), with median time between completion of chemotherapy and enrollment of 14 months (range 1-92). At 8 weeks, participants in the IA arm experienced significant improvements in PNQ sensory score (-1.0 +/- 0.9 vs. -0.3 +/- 0.6; p = .01), FACT-NTX summary score (8.7 +/- 8.9 vs. 1.2 +/- 5.4; p = .002), and BPI-SF pain severity score (-1.1 +/- 1.7 vs. 0.3 +/- 1.5; p = .03), compared with those in the CG arm. No serious side effects were observed.
   Conclusion Women with CIPN after adjuvant taxane therapy for breast cancer experienced significant improvements in neuropathic symptoms from an 8-week acupuncture treatment regimen. Additional larger studies are needed to confirm these findings.
   Implications for Practice Chemotherapy-induced peripheral neuropathy (CIPN) is a toxicity that often persists for months to years after the completion of adjuvant chemotherapy for early breast cancer. In a randomized pilot trial of 40 breast cancer survivors with CIPN, an 8-week acupuncture intervention (vs. usual care) led to a statistically and clinically significant improvement in subjective sensory symptoms including neuropathic pain and paresthesia. Given the lack of effective therapies and established safety profile of acupuncture, clinicians may consider acupuncture as a treatment option for mild to moderate CIPN in practice.
C1 [Lu Weidong; Freedman, Rachel A.; Lin, Nancy U.; Partridge, Ann H.; Rosenthal, David S.; Ligibel, Jennifer A.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA.
   [Giobbie-Hurder, Anita] Dana Farber Canc Inst, Dept Data Sci, Div Biostat, Boston, MA 02115 USA.
   [Shin, Im Hee] Catholic Univ Daegu, Dept Med Stat & Informat, Sch Med, Daegu, South Korea.
C3 Harvard University; Harvard University Medical Affiliates; Dana-Farber
   Cancer Institute; Harvard University; Harvard University Medical
   Affiliates; Dana-Farber Cancer Institute; Catholic University of Daegu
RP Lu, WD (corresponding author), Dana Farber Canc Inst, Dept Med Oncol, Leonard P Zakim Ctr Integrat Therapies & Hlth Liv, 450 Brookline Ave, Boston, MA 02215 USA.
EM weidong_lu@dfci.harvard.edu
RI Giobbie-Hurder, Anita/JNR-8667-2023; Lin, Nancy/ACF-8569-2022
OI Giobbie-Hurder, Anita/0000-0003-2496-7737; 
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   Bandos H, 2018, JNCI-J NATL CANCER I, V110, DOI 10.1093/jnci/djx162
   Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Bao T, 2016, BREAST CANCER RES TR, V159, P327, DOI 10.1007/s10549-016-3939-0
   Cella D, 2003, CANCER-AM CANCER SOC, V98, P822, DOI 10.1002/cncr.11578
   CELLA DF, 1993, J CLIN ONCOL, V11, P570, DOI 10.1200/JCO.1993.11.3.570
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Cocks K, 2008, EUR J CANCER, V44, P1793, DOI 10.1016/j.ejca.2008.05.008
   Ezzo J, 2005, J CLIN ONCOL, V23, P7188, DOI 10.1200/JCO.2005.06.028
   Franconi G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/516916
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Gewandter JS, 2017, NEUROLOGY, V89, P859, DOI 10.1212/WNL.0000000000004272
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   Hausheer FH, 2006, SEMIN ONCOL, V33, P15, DOI 10.1053/j.seminoncol.2005.12.010
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Kolb NA, 2016, JAMA NEUROL, V73, P860, DOI 10.1001/jamaneurol.2016.0383
   Kuroi K, 2009, SUPPORT CARE CANCER, V17, P1071, DOI 10.1007/s00520-008-0550-x
   Li K, 2019, CURR ONCOL, V26, pE147, DOI 10.3747/co.26.4261
   MacPherson H, 2002, J ALTERN COMPLEM MED, V8, P85, DOI 10.1089/107555302753507212
   Majithia N, 2016, SUPPORT CARE CANCER, V24, P1439, DOI 10.1007/s00520-015-3063-4
   McCrary JM, 2017, SUPPORT CARE CANCER, V25, P3485, DOI 10.1007/s00520-017-3772-y
   Molassiotis A, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419836501
   Norman GR, 2003, MED CARE, V41, P582, DOI 10.1097/00005650-200305000-00004
   OSOBA D, 1994, QUAL LIFE RES, V3, P353, DOI 10.1007/BF00451727
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Shimozuma K, 2012, SUPPORT CARE CANCER, V20, P3355, DOI 10.1007/s00520-012-1492-x
   Shimozuma K, 2009, SUPPORT CARE CANCER, V17, P1483, DOI 10.1007/s00520-009-0613-7
   Simon NB, 2017, QUAL LIFE RES, V26, P2763, DOI 10.1007/s11136-017-1635-0
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Tanabe Y, 2013, INT J CLIN ONCOL, V18, P132, DOI 10.1007/s10147-011-0352-x
   Visovsky Constance, 2007, Clin J Oncol Nurs, V11, P901
   Winters-Stone KM, 2017, J CLIN ONCOL, V35, P2604, DOI 10.1200/JCO.2016.71.3552
   Wong K, 2013, SUPPORT CARE CANCER, V21, P1893, DOI 10.1007/s00520-013-1731-9
   Xu Wei-Ru, 2010, Zhongguo Zhen Jiu, V30, P457
NR 35
TC 115
Z9 145
U1 4
U2 49
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1083-7159
EI 1549-490X
J9 ONCOLOGIST
JI Oncologist
PD APR
PY 2020
VL 25
IS 4
BP 310
EP 318
DI 10.1634/theoncologist.2019-0489
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA LE4IN
UT WOS:000526683000010
PM 32297442
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Yan, S
   Xie, LY
   Duan, XX
   Tan, JX
   Yang, S
   Meng, L
   Zhong, QH
   Lin, WD
   Yang, JN
   Xiao, YY
   Jiang, XY
AF Yan, Sen
   Xie, Ling-Yao
   Duan, Xia-Xia
   Tan, Jia-Xuan
   Yang, Song
   Meng, Ling
   Zhong, Qing-Hua
   Lin, Wei-Di
   Yang, Jia-Ni
   Xiao, Yao-Yao
   Jiang, Xueyu
TI Electroacupuncture improves apoptosis of nucleus pulposus cells via the
   IL-22/JAK2-STAT3 signaling pathway in a rat model of cervical
   intervertebral disk degeneration
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article; Early Access
DE cervical intervertebral disk degeneration; cervical spondylosis;
   electroacupuncture; interleukin 22; JAK2-STAT3
ID NECK PAIN; IN-VIVO; ACUPUNCTURE; ALPHA
AB Background: Cervical spondylosis (CS) is a prevalent disorder that can have a major negative impact on quality of life. Traditional conservative treatment has limited efficacy, and electroacupuncture (EA) is a novel treatment option. We investigated the application and molecular mechanism of EA treatment in a rat model of cervical intervertebral disk degeneration (CIDD).Methods: The CIDD rat model was established, following which rats in the electroacupuncture (EA) group received EA. For overexpression of IL-22 or inhibition of JAK2-STAT3 signaling, the rats were injected intraperitoneally with recombinant IL-22 protein (p-IL-22) or the JAK2-STAT3 (Janus kinase 2-signal transducer and activator of transcription protein 3) inhibitor AG490 after model establishment. Rat nucleus pulposus (NP) cells were isolated and cultured. Cell counting kit-8 and flow cytometry were used to analyze the viability and apoptosis of the NP cells. Expression of IL-22, JAK2 and STAT3 was determined using RT-qPCR. Expression of IL-22/JAK2-STAT3 pathway and apoptosis related proteins was detected by Western blotting (WB).Results: EA protected the NP tissues of CIDD rats by regulating the IL-22/JAK2-STAT3 pathway. Overexpression of IL-22 significantly promoted the expression of tumor necrosis factor (TNF)-alpha, IL-6, IL-1 beta, matrix metalloproteinase (MMP)3 and MMP13 compared with the EA group. WB demonstrated that the expression of IL-22, p-JAK2, p-STAT3, caspase-3 and Bax in NP cells of the EA group was significantly reduced and Bcl-2 elevated compared with the model group. EA regulated cytokines and MMP through activation of IL-22/JAK2-STAT3 signaling in CIDD rat NP cells.Conclusion: We demonstrated that EA affected apoptosis by regulating the IL-22/JAK2-STAT3 pathway in NP cells and reducing inflammatory factors in the CIDD rat model. The results extend our knowledge of the mechanisms of action underlying the effects of EA as a potential treatment approach for CS in clinical practice.
C1 [Yan, Sen; Xie, Ling-Yao; Duan, Xia-Xia; Tan, Jia-Xuan; Yang, Song; Meng, Ling; Zhong, Qing-Hua; Lin, Wei-Di; Yang, Jia-Ni; Xiao, Yao-Yao; Jiang, Xueyu] Yueyang Hosp Tradit Chinese Med, Acupuncture Dept 2, 269 Fengqiaohu Rd, Yueyang 414000, Hunan, Peoples R China.
RP Jiang, XY (corresponding author), Yueyang Hosp Tradit Chinese Med, Acupuncture Dept 2, 269 Fengqiaohu Rd, Yueyang 414000, Hunan, Peoples R China.
EM j_xueyu@126.com
RI Tan, Jiaxuan/OYE-9158-2025
FU Program from Ministry of Science and Technology [2018YFC1707800];
   General Program of Natural Science Foundation of Hunan Province, China
   [2019JJ40217]; Joint Project of Hunan Health Commission and Science and
   Technology [2020SK52801]
FX The authors disclosed receipt of the following financial support for the
   research, authorship and/or publication of this article: This article
   was supported by: the Program from Ministry of Science and Technology
   (2018YFC1707800); the General Program of Natural Science Foundation of
   Hunan Province, China (2019JJ40217); and the Joint Project of Hunan
   Health Commission and Science and Technology (2020SK52801).
CR Cazzanelli P, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103601
   Chen B, 2017, INFLAMMATION, V40, P612, DOI 10.1007/s10753-017-0508-6
   Chen L, 2021, PAIN, V162, P728, DOI 10.1097/j.pain.0000000000002071
   Chen SF, 2017, APOPTOSIS, V22, P626, DOI 10.1007/s10495-017-1358-2
   Chen ZH, 2020, CHIN J INTEGR MED, V26, P375, DOI 10.1007/s11655-019-3038-2
   Clouet J, 2009, JOINT BONE SPINE, V76, P614, DOI 10.1016/j.jbspin.2009.07.002
   Dhar R, 2019, LIFE SCI, V238, DOI 10.1016/j.lfs.2019.116962
   Ding F, 2012, APOPTOSIS, V17, P579, DOI 10.1007/s10495-012-0708-3
   Ferrara LA, 2012, ADV ORTHOP, V2012, DOI 10.1155/2012/493605
   Gu CL, 2019, J PAIN RES, V12, P1441, DOI 10.2147/JPR.S199798
   Guan RQ, 2021, MOL MED REP, V24, DOI 10.3892/mmr.2021.12131
   Guo Y, 2020, WORLD J GASTROENTERO, V26, P2440, DOI 10.3748/wjg.v26.i19.2440
   Hainzl E, 2015, J IMMUNOL, V195, P5011, DOI 10.4049/jimmunol.1402565
   Huang ZL, 2020, HUM CELL, V33, P850, DOI 10.1007/s13577-020-00373-3
   James SL, 2018, LANCET, V392, P1789, DOI [10.1016/S0140-6736(18)32279-7, 10.1016/S0140-6736(18)32335-3, 10.1016/s0140-6736(18)32335-3]
   Kelly JC, 2012, ADV ORTHOP, V2012, DOI 10.1155/2012/393642
   Liao J, 2014, J TRADIT CHIN MED, V34, P684, DOI 10.1016/S0254-6272(15)30083-2
   Liu BY, 2011, J TRANSL MED, V9, DOI 10.1186/1479-5876-9-111
   Liu EH, 2020, J BIOL REG HOMEOS AG, V34, P1719, DOI [10.23812/20-326-a, 10.23812/20-326-A]
   Liu Q., 2022, J Clin Lab Anal, V36
   Lv YW, 2018, BMC MUSCULOSKEL DIS, V19, DOI 10.1186/s12891-018-2234-0
   Maiji Me-Wu-Jia, 2019, Zhen Ci Yan Jiu, V44, P835, DOI 10.13702/j.1000-0607.180769
   Meyer LK, 2020, BLOOD, V136, P657, DOI 10.1182/blood.2020006075
   Pei F, 2022, EXPLORE-NY, V18, P533, DOI 10.1016/j.explore.2021.10.012
   Sekikawa A, 2005, GASTROENTEROLOGY, V128, P642, DOI 10.1053/j.gastro.2004.12.045
   Seo SY, 2017, AM J CHINESE MED, V45, P1573, DOI 10.1142/S0192415X17500859
   Shedid D, 2007, NEUROSURGERY, V60, P7, DOI 10.1227/01.NEU.0000215430.86569.C4
   Stoffman MR, 2005, NEUROSURGERY, V57, P307, DOI 10.1227/01.NEU.0000166664.19662.43
   Suzuki S, 2017, SPINE, V42, pE817, DOI 10.1097/BRS.0000000000001982
   Tetreault LA, 2015, EUR SPINE J, V24, pS236, DOI 10.1007/s00586-013-2658-z
   Wang CL, 2016, CLIN INTERV AGING, V11, P47, DOI 10.2147/CIA.S93118
   Wang D, 2020, FRONT CELL DEV BIOL, V8, DOI 10.3389/fcell.2020.613006
   WANG P, 2020, MEDICINE, V99
   Wang R, 2019, LIFE SCI, V230, P28, DOI 10.1016/j.lfs.2019.05.045
   Wang SQ, 2018, BIOCHEM BIOPH RES CO, V503, P1605, DOI 10.1016/j.bbrc.2018.07.088
   Wang YJ, 2006, SPINE, V31, P1532, DOI 10.1097/01.brs.0000222019.84095.23
   Xie L, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1978-2
   Xu Q., 2022, Medicine, V101
   Yao YA, 2022, J IMMUNOL RES, V2022, DOI 10.1155/2022/8071234
   Zhang WC, 2008, CLIN CANCER RES, V14, P6432, DOI 10.1158/1078-0432.CCR-07-4401
   Zhao M, 2017, INT J RHEUM DIS, V20, P214, DOI 10.1111/1756-185X.12939
   Zhao XY, 2020, BIOL RES, V53, DOI 10.1186/s40659-020-00297-0
   Zhou S., Shanghai J Acupunct Moxibustion, V2017, P1092
NR 43
TC 4
Z9 4
U1 0
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD 2024 MAY 3
PY 2024
DI 10.1177/09645284241248465
EA MAY 2024
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA PN2H3
UT WOS:001214686200001
PM 38702866
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Liou, K
   Romero, SAD
   Baser, RE
   Wong, G
   Xiao, H
   Deng, G
   Mo, ZL
   Walker, D
   MacLeod, JE
   Li, QS
   Barton-Burke, M
   Panageas, K
   Farrar, JT
   Epstein, AS
AF Mao, Jun J.
   Liou, Kevin
   Romero, Sally A. D.
   Baser, Raymond E.
   Wong, Greta
   Xiao, Han
   Deng, Gary
   Mo, Zunli
   Walker, Desiree
   MacLeod, Jodi Elizabeth
   Li, Qing Susan
   Barton-Burke, Margaret
   Panageas, Katherine
   Farrar, John T.
   Epstein, Andrew S.
TI Acupuncture versus massage for pain in patients living with advanced
   cancer: The IMPACT randomized clinical trial
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)
CY JUN 02-06, 2023
CL Chicago, IL
SP Amer Soc Clin Oncol
C1 Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY USA.
   Mem Sloan Kettering Canc Ctr, New York, NY USA.
   Univ Calif San Diego, La Jolla, CA USA.
   Mem Sloan Kettering Canc Ctr Basking Ridge New Je, Basking Ridge, NJ USA.
   Miami Canc Inst, Miami, FL USA.
   Univ Penn, Philadelphia, PA USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; University of California System; University of California San
   Diego; University of Pennsylvania
RI Farrar, John/AAP-4788-2021
FU Patient-Centered Outcomes Research Institute (PCORI); U.S. National
   Institutes of Health
FX Patient-Centered Outcomes Research Institute (PCORI); U.S. National
   Institutes of Health.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD JUN 1
PY 2023
VL 41
IS 16
SU S
MA 12101
PG 1
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology
GA P9JR8
UT WOS:001053772002978
DA 2026-01-16
ER

PT J
AU Crew, KD
   Capodice, JL
   Greenlee, H
   Brafman, L
   Fuentes, D
   Awad, D
   Tsai, WY
   Hershman, DL
AF Crew, Katherine D.
   Capodice, Jillian L.
   Greenlee, Heather
   Brafman, Lois
   Fuentes, Deborah
   Awad, Danielle
   Tsai, Wei Yann
   Hershman, Dawn L.
TI Randomized, Blinded, Sham-Controlled Trial of Acupuncture for the
   Management of Aromatase Inhibitor-Associated Joint Symptoms in Women
   With Early-Stage Breast Cancer
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID POSTMENOPAUSAL WOMEN; ALTERNATIVE MEDICINE; CHRONIC PAIN; TAMOXIFEN
   THERAPY; CLINICAL-TRIALS; KNEE; OSTEOARTHRITIS; COMPLEMENTARY;
   XEROSTOMIA; LETROZOLE
AB Purpose
   Women with breast cancer (BC) treated with aromatase inhibitors (AIs) may experience joint symptoms that can lead to discontinuation of effective therapy. We examined whether acupuncture improves AI-induced arthralgias in women with early-stage BC.
   Methods
   We conducted a randomized, controlled, blinded study comparing true acupuncture (TA) versus sham acupuncture (SA) twice weekly for 6 weeks in postmenopuasal women with BC who had self-reported musculoskeletal pain related to AIs. TA included full body/auricular acupuncture and joint-specific point prescriptions, whereas SA involved superficial needle insertion at nonacupoint locations. Outcome measures included the Brief Pain Inventory-Short Form (BPI-SF), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Modified Score for the Assessment of Chronic Rheumatoid Affections of the Hands (M-SACRAH) obtained at baseline and at 3 and 6 weeks.
   Results
   Of 51 women enrolled, 43 women were randomly assigned and 38 were evaluable. Baseline characteristics were comparable between the two groups. Our primary end point was the difference in mean BPI-SF worst pain scores at 6 weeks, which was lower for TA compared with SA (3.0 v 5.5; P < .001). We also found differences between TA and SA in pain severity (2.6 v 4.5; P = .003) and pain-related interference (2.5 v 4.5; P = .002) at 6 weeks. Similar findings were seen for the WOMAC and M-SACRAH scores. The acupuncture intervention was well-tolerated.
   Conclusion
   Women with AI-induced arthralgias treated with TA had significant improvement of joint pain and stiffness, which was not seen with SA. Acupuncture is an effective and well-tolerated strategy for managing this common treatment-related side effect. J Clin Oncol 28: 1154-1160. (C) 2010 by American Society of Clinical Oncology
C1 [Hershman, Dawn L.] Columbia Univ, Dept Epidemiol & Biostat, Mailman Sch Publ Hlth, New York, NY 10032 USA.
   Natl Cheng Kung Univ, Dept Stat, Tainan 70101, Taiwan.
C3 Columbia University; National Cheng Kung University
RP Hershman, DL (corresponding author), Columbia Univ, Dept Epidemiol & Biostat, Mailman Sch Publ Hlth, 161 Ft Washington Ave,10-1068, New York, NY 10032 USA.
EM dlh23@columbia.edu
RI Hershman, Dawn/AAG-2114-2020; Greenlee, Heather/A-1439-2011
FU Lance Armstrong Young Investigator Award; AVON Products Foundation;
   Breast Cancer Research Foundation
FX Supported in part by a Lance Armstrong Young Investigator Award (K.D.C.)
   and an Advanced Clinical Research Award from the American Society of
   Clinical Oncology with funding from AVON Products Foundation and the
   Breast Cancer Research Foundation (D.L.H.).
CR ANDERSSON S, 1995, MED HYPOTHESES, V45, P271, DOI 10.1016/0306-9877(95)90117-5
   [Anonymous], 2003, COMM TERM CRIT ADV E
   Baum M., 2002, LANCET, V360, P1520
   BELLAMY N, 1988, J RHEUMATOL, V15, P1833
   Brady MJ, 1997, J CLIN ONCOL, V15, P974, DOI 10.1200/JCO.1997.15.3.974
   Castel LD, 2007, J PAIN SYMPTOM MANAG, V34, P380, DOI 10.1016/j.jpainsymman.2006.12.007
   CHEN C, 2004, XIN ZHONG YI, V36, P46
   CHEN X, 1999, CHINESE ACUPUNCTURE, P134
   CHRISTENSEN BV, 1992, ACTA ANAESTH SCAND, V36, P519, DOI 10.1111/j.1399-6576.1992.tb03511.x
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Coombes RC, 2004, NEW ENGL J MED, V350, P1081, DOI 10.1056/NEJMoa040331
   Crew Katherine D, 2007, J Cancer Surviv, V1, P283, DOI 10.1007/s11764-007-0034-x
   Crew KD, 2007, J CLIN ONCOL, V25, P3877, DOI 10.1200/JCO.2007.10.7573
   Dougherty DD, 2008, BEHAV BRAIN RES, V193, P63, DOI 10.1016/j.bbr.2008.04.020
   Ernst E, 2007, AM J CHINESE MED, V35, P21, DOI 10.1142/S0192415X07004588
   Ernst E, 2001, AM J MED, V110, P481, DOI 10.1016/S0002-9343(01)00651-9
   Ezzo J, 2001, ARTHRITIS RHEUM, V44, P819, DOI 10.1002/1529-0131(200104)44:4<819::AID-ANR138>3.3.CO;2-G
   Farrar JT, 2001, PAIN, V94, P149, DOI 10.1016/S0304-3959(01)00349-9
   Goss PE, 2003, NEW ENGL J MED, V349, P1793, DOI 10.1056/NEJMoa032312
   Goss PE, 2005, JNCI-J NATL CANCER I, V97, P1262, DOI 10.1093/jnci/dji250
   HAN JS, 1982, ANNU REV PHARMACOL, V22, P193, DOI 10.1146/annurev.pa.22.040182.001205
   Henry NL, 2008, BREAST CANCER RES TR, V111, P365, DOI 10.1007/s10549-007-9774-6
   Howell A, 2005, LANCET, V365, P60, DOI 10.1016/s0140-6736(04)17666-6
   Jensen MP, 1999, PAIN, V83, P157, DOI 10.1016/S0304-3959(99)00101-3
   Johnstone PAS, 2002, CANCER, V94, P1151, DOI 10.1002/cncr.10348
   Johnstone PAS, 2001, INT J RADIAT ONCOL, V50, P353, DOI 10.1016/S0360-3016(00)01530-3
   Kaptchuk TJ, 2006, BMJ-BRIT MED J, V332, P391, DOI 10.1136/bmj.38726.603310.55
   KAWAKITA K, 1993, AM J ACUPUNCTURE, V21, P331
   Kawakita K, 2006, J PHARMACOL SCI, V100, P443, DOI 10.1254/jphs.CRJ06004X
   Lafferty WE, 2006, AM J MANAG CARE, V12, P397
   Linde K, 2007, PAIN, V128, P264, DOI 10.1016/j.pain.2006.12.006
   Lu Weidong, 2005, Semin Oncol Nurs, V21, P190, DOI 10.1016/j.soncn.2005.04.008
   MacPherson H, 2002, J ALTERN COMPLEM MED, V8, P85, DOI 10.1089/107555302753507212
   MATSUMOTO T, 1981, J JPN SOC ACUPUNCT M, V30, P209
   McManus Claire A, 2007, Acupunct Med, V25, P36
   Moffet HH, 2009, J ALTERN COMPLEM MED, V15, P213, DOI 10.1089/acm.2008.0356
   Morales L, 2008, J CLIN ONCOL, V26, P3147, DOI 10.1200/JCO.2007.15.4005
   Pelletier KR, 1999, AM J HEALTH PROMOT, V14, P125, DOI 10.4278/0890-1171-14.2.125
   POMERANZ B, 1976, LIFE SCI, V19, P1757, DOI 10.1016/0024-3205(76)90084-9
   Qin W, 2008, MOL PAIN, V4, DOI 10.1186/1744-8069-4-55
   Roscoe JA, 2003, J PAIN SYMPTOM MANAG, V26, P731, DOI 10.1016/S0885-3924(03)00254-9
   Sautner J, 2004, RHEUMATOLOGY, V43, P1409, DOI 10.1093/rheumatology/keh360
   Scharf HP, 2006, ANN INTERN MED, V145, P12, DOI 10.7326/0003-4819-145-1-200607040-00005
   Schnyer RN, 2002, J ALTERN COMPLEM MED, V8, P623, DOI 10.1089/107555302320825147
   SHINOHARA S, 1982, J JPN SOC ACUPUNCT M, V32, P17
   SJOLUND B, 1977, ACTA PHYSIOL SCAND, V100, P382, DOI 10.1111/j.1748-1716.1977.tb05964.x
   Steyer TE, 2002, ALTERN THER HEALTH M, V8, P84
   Takeda W, 1994, Arthritis Care Res, V7, P118, DOI 10.1002/art.1790070304
   Thürlimann B, 2005, NEW ENGL J MED, V353, P2747
   Vas J, 2004, BMJ-BRIT MED J, V329, P1216, DOI 10.1136/bmj.38238.601447.3A
   Vincent C, 2001, BRIT MED J, V323, P467, DOI 10.1136/bmj.323.7311.467
   Witt C, 2005, LANCET, V366, P136, DOI 10.1016/S0140-6736(05)66871-7
   Wong RKW, 2003, INT J RADIAT ONCOL, V57, P472, DOI 10.1016/S0360-3016(03)00572-8
   2006, HLTH QUAL LIFE OUTCO, V4, P79
NR 54
TC 210
Z9 242
U1 2
U2 70
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAR 1
PY 2010
VL 28
IS 7
BP 1154
EP 1160
DI 10.1200/JCO.2009.23.4708
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 560HG
UT WOS:000274892500014
PM 20100963
DA 2026-01-16
ER

PT J
AU Zhang, XW
   Hou, WB
   Pu, FL
   Wang, XF
   Wang, YR
   Yang, M
   Cheng, K
   Wang, YY
   Robinson, N
   Liu, JP
AF Zhang, Xiao-wen
   Hou, Wen-bin
   Pu, Feng-lan
   Wang, Xue-feng
   Wang, Yi-ran
   Yang, Ming
   Cheng, Ke
   Wang, Yuyi
   Robinson, Nicola
   Liu, Jian-ping
TI Acupuncture for cancer-related conditions: An overview of systematic
   reviews
SO PHYTOMEDICINE
LA English
DT Review
DE Acupuncture; Cancer -related conditions; Overview; Systematic reviews;
   Randomized controlled trials
ID INHIBITOR-INDUCED ARTHRALGIA; BREAST-CANCER; PALLIATIVE CARE; HOT
   FLASHES; PLACEBO; FATIGUE; SAFETY; BURDEN; PAIN
AB Background: Acupuncture is commonly used for cancer-related conditions worldwide, and evidence is increasing year on year. There is a need to summarize the evidence of acupuncture for cancer-related conditions comprehensively and critically.
   Objective: To evaluate and summarize the systematic reviews (SRs) that assess the effects and safety of acupuncture for cancer-related conditions, and to inform clinical practice and future studies.
   Methods: A comprehensive search was conducted on Pubmed, Embase, the Cochrane Library, Web of Science, CNKI, VIP, Sinomed, and Wanfang from their inception to October 16, 2021. SRs of randomized controlled trials (RCTs) on acupuncture for cancer-related conditions were to be included. Two reviewers screened the eligible articles, and four reviewers in pair extracted data and assessed the methodological quality/risk of bias of all included reviews by AMSTAR 2 and ROBIS tools. The overlap of primary studies was measured by calculating corrected covered areas. Data from the included reviews were synthesized with a summary of meta-analysis or narrative description.
   Results: Fifty-one SRs of RCTs on acupuncture for cancer-related conditions were included and synthesized. The methodological quality of SRs included 1 "high", 5 "low" and 45 "very low" by AMSTAR 2. Sixteen SRs assessed as low risk of bias (31.37%), and 35 SRs had high risk of bias (68.63%) by ROBIS. Acupuncture showed effective on systemic conditions in relation to different cancers, including cancer-related pain (17 SRs, 80 RCTs), fatigue (7 SRs, 18 RCTs), insomnia (4 SRs, 10 RCTs), quality of life (2 SRs, 15 RCTs); conditions in relation to chemoradiotherapy, including nausea and vomiting (3 SRs, 36 RCTs) and bone marrow suppression (2 SRs, 21 RCTs); and conditions in relation to specific cancers, including breast cancer-related menopause (3 SRs, 6 RCTs), hot flashes (12 SRs, 13 RCTs), arthralgia (5 SRs, 10 RCTs), and nasopharyngeal cancer-related dysphagia (1 SRs, 7 RCTs). Acupuncture appeared to have benefit for patients with lymphoedema (3 SRs, 3 RCTs), gastrointestinal function (5 SRs, 27 RCTs), and xerostomia (4 SRs, 7 RCTs). Limited evidence showed inconsistent results on acupuncture for chemotherapy-induced peripheral neuropathy (3 SRs, 6 RCTs), depression and anxiety (3 SRs, 9 RCTs). Acupuncture was regarded as a safe therapy for cancer patients as no severe adverse events related were reported.
   Conclusion: Evidence from SRs showed that acupuncture is beneficial to cancer survivors with cancer-related pain, fatigue, insomnia, improved quality of life, nausea and vomiting, bone marrow suppression, menopausal symptoms, arthralgia, and dysphagia, and may also be potential for lymphoedema, gastrointestinal function, and xerostomia. For neuropathy, depression and anxiety, acupuncture should be used as an option based on individual conditions. Acupuncture is relatively safe without serious adverse events. More well-designed clinical trials of acupuncture are recommended on cancer-related depression and anxiety, arthralgia, xerostomia, gastrointestinal dysfunction and dysphagia.
C1 [Zhang, Xiao-wen; Pu, Feng-lan; Robinson, Nicola; Liu, Jian-ping] Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing 100029, Peoples R China.
   [Wang, Xue-feng; Wang, Yi-ran] Beijing Univ Chinese Med, Sch Humanities, Beijing 100029, Peoples R China.
   [Yang, Ming] Beijing Univ Chinese Med, Affiliated Hosp 3, Beijing 100029, Peoples R China.
   [Cheng, Ke] Shanghai Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Shanghai 201203, Peoples R China.
   [Wang, Yuyi] Chongqing Hosp Tradit Chinese Med, Chongqing 400011, Peoples R China.
   [Robinson, Nicola] London South Bank Univ, Inst Hlth & Social Care, London, England.
   [Liu, Jian-ping] UiT Arctic Univ Tromso, Fac Hlth Sci, Natl Res Ctr Complementary & Alternat Med NAFKAM, Dept Community Med, N-9037 Tromso, Norway.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine; Shanghai University of
   Traditional Chinese Medicine; London South Bank University; UiT The
   Arctic University of Tromso
RP Liu, JP (corresponding author), Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing 100029, Peoples R China.
EM Liujp@bucm.edu.cn
RI pu, fl/LVR-8077-2024; Wang, Yuyi/IUQ-5440-2023
OI Robinson, Nicola/0000-0001-5256-4527; Wang, Yuyi/0000-0002-4031-0420;
   Zhang, Xiaowen/0000-0002-1724-4381
FU key project of the National Natural Science Foundation of China
   [81830115]; NCCIH [AT001293, 020468C]; International development and
   capacity enhancement of evidence -based Chinese medicine Project,
   Ministry of Science and Technology of the People's Republic of China
   [G20200001187]
FX This work was supported by the key project of the National Natural
   Science Foundation of China (No. 81830115)"Key techniques and outcome
   research for therapeutic effect of traditional Chinese medicine as
   complex intervention based on holistic system and pattern
   differentiation and prescription". Prof. JP Liu was partly supported by
   the NCCIH grant (AT001293 with sub -award No. 020468C) . Prof. N
   Robinson (visiting professor of Beijing University of Chinese Medicine)
   was funded by International development and capacity enhancement of
   evidence -based Chinese medicine Project, Ministry of Science and
   Technology of the People's Republic of China (G20200001187) .
CR Anshasi H, 2021, PALLIAT SUPPORT CARE, V19, P361, DOI 10.1017/S1478951520001194
   Bae K, 2015, INTEGR CANCER THER, V14, P496, DOI 10.1177/1534735415596573
   Benedetti F, 2013, PHYSIOL REV, V93, P1207, DOI 10.1152/physrev.00043.2012
   Bhakta N, 2019, LANCET ONCOL, V20, pE42, DOI 10.1016/S1470-2045(18)30761-7
   Birch S, 2019, INTEGR MED RES, V8, P160, DOI 10.1016/j.imr.2019.05.002
   Chen L, 2017, BREAST, V33, P132, DOI 10.1016/j.breast.2017.03.015
   Chen YP, 2016, J CANCER RES THER, V12, P535, DOI 10.4103/0973-1482.172716
   Chien TJ, 2020, CLIMACTERIC, V23, P130, DOI 10.1080/13697137.2019.1664460
   Chien TJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419886662
   Chien TJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419866910
   Chien TJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180918
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Chiu HY, 2016, CANCER NURS, V39, P228, DOI 10.1097/NCC.0000000000000278
   Choi TY, 2017, INTEGR CANCER THER, V16, P135, DOI 10.1177/1534735416664172
   Choi TY, 2012, COMPLEMENT THER MED, V20, P447, DOI 10.1016/j.ctim.2012.07.007
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Craig Wm, 1869, Edinb Med J, V14, P617
   Dans M, 2021, J NATL COMPR CANC NE, V19, P780, DOI 10.6004/jnccn.2021.0033
   Dong B, 2021, BMC COMPLEMENT MED, V21, DOI 10.1186/s12906-020-03193-y
   Garcia MK, 2015, MED ACUPUNCT, V27, P158, DOI 10.1089/acu.2015.1104
   Garcia MK, 2015, CANCER-AM CANCER SOC, V121, P3948, DOI 10.1002/cncr.29630
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Ge L, 2022, CHIN MED-UK, V17, DOI 10.1186/s13020-021-00558-4
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Guo J, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420959442
   Hu CQ, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1720239
   [黄厚强 Huang Houqiang], 2016, [护理学杂志, Journal of Nursing Science], V31, P90
   Huang Rui, 2021, Zhongguo Zhen Jiu, V41, P557, DOI 10.13703/j.0255-2930.20200618-k0005
   Hughes JG, 2019, ACUPUNCT MED, V37, P223, DOI 10.1136/acupmed-2017-011592
   Kim KH, 2016, ACUPUNCT MED, V34, P248, DOI 10.1136/acupmed-2015-010941
   Kim TH, 2022, EUR J INTEGR MED, V49, DOI 10.1016/j.eujim.2021.101605
   Lee MS, 2009, BREAST CANCER RES TR, V115, P497, DOI 10.1007/s10549-008-0230-z
   Li DH, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5558590
   Li H., 2016, SYSTEMATIC REV RANDO
   Li HJ, 2021, J ALTERN COMPLEM MED, V27, P1084, DOI 10.1089/acm.2021.0133
   Li K, 2019, CURR ONCOL, V26, pE147, DOI 10.3747/co.26.4261
   Lian WL, 2014, CHIN J INTEGR MED, V20, P136, DOI 10.1007/s11655-013-1439-1
   Liu M.T., 2020, MED INNOV CHINA, V17, P159, DOI [10.3969/j.issn.1674- 4985.2020.34.042, DOI 10.3969/J.ISSN.1674-4985.2020.34.042]
   Liu XM, 2021, INTEGR CANCER THER, V20, DOI 10.1177/1534735420980811
   Liu YH, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/2504021
   Lopes LC, 2016, REV LAT-AM ENFERM, V24, DOI 10.1590/1518-8345.0647.2762
   [卢静 Lu Jing], 2018, [南京医科大学学报. 自然科学版, Journal of Nanjing Medical University. Natural Sciences Edition], V38, P1533
   Lu Weidong, 2007, J Soc Integr Oncol, V5, P1, DOI 10.2310/7200.2006.035
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Mao HJ, 2016, CANCER-AM CANCER SOC, V122, P3667, DOI 10.1002/cncr.30189
   McGuinness LA, 2021, BMJ, V372, DOI [DOI 10.1136/BMJ.N71, 10.1136/bmj.n71]
   Ni XX, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420980825
   Paley CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub3
   Peng H., 2010, J CHIN INTEGR MED, V8, P501, DOI [10.3736/jcim20100601, DOI 10.3736/JCIM20100601]
   Piao H.H., 2010, LISHIZHEN MED MAT ME, V21, P1476, DOI [10.3969/j.issn.1008-0805.2010.06.087, DOI 10.3969/J.ISSN.1008-0805.2010.06.087]
   Pieper D, 2014, J CLIN EPIDEMIOL, V67, P368, DOI 10.1016/j.jclinepi.2013.11.007
   Posadzki P, 2013, SUPPORT CARE CANCER, V21, P2067, DOI 10.1007/s00520-013-1765-z
   Rositch AF, 2020, LANCET GLOB HEALTH, V8, pE153, DOI 10.1016/S2214-109X(20)30001-2
   Shea BJ, 2017, BMJ-BRIT MED J, V358, DOI 10.1136/bmj.j4008
   Shen H., 2015, P CHINESE MED ENG BR, P845
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Tao W.W., 2019, CHIN J PRACT NURS, P1836, DOI [10.3760/cma.j.issn.1672-7088.2019.23.017, DOI 10.3760/CMA.J.ISSN.1672-7088.2019.23.017]
   Towler P, 2013, SUPPORT CARE CANCER, V21, P2913, DOI 10.1007/s00520-013-1882-8
   Wang CCF, 2019, EUR J INTEGR MED, V27, P81, DOI 10.1016/j.eujim.2019.03.004
   Wang J.F., 2020, J Emerg Tradit Chin -med, V29, P1140, DOI [10.3969/j.issn.1004-745X.2020.07.005, DOI 10.3969/J.ISSN.1004-745X.2020.07.005]
   Wang S., 2020, META ANAL ACUPUNCTUR
   Wen YF, 2021, J HEMATOL ONCOL, V14, DOI 10.1186/s13045-021-01093-3
   Whiting P, 2016, J CLIN EPIDEMIOL, V69, P225, DOI 10.1016/j.jclinepi.2015.06.005
   World Health Organization (WHO), 2022, CANC WHO NEWSR FACT
   Wu XY, 2015, SCI REP-UK, V5, DOI 10.1038/srep16776
   Yang J, 2021, BMJ SUPPORT PALLIAT, V11, P264, DOI 10.1136/bmjspcare-2020-002638
   Yang P, 2021, Shanghai J Acupunct Mox, V40, P366, DOI [10.13460/j.issn.1005-0957.2021.03.0366, DOI 10.13460/J.ISSN.1005-0957.2021.03.0366]
   Yang YL, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/1618767
   You L, 2021, ESMO OPEN, V6, DOI 10.1016/j.esmoop.2021.100255
   Yu SB, 2020, EXPLORE-NY, V16, P97, DOI 10.1016/j.explore.2019.06.002
   Yuan C, 2020, J Yunnan Univ Tradit Chin Med, V43, P61, DOI [10.19288/j.cnki.issn.1000-2723.2020.04.011, DOI 10.19288/J.CNKI.ISSN.1000-2723.2020.04.011]
   Zeng YW, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-049318
   Zhang FY, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2304-8
   Zhang H.B., 2015, P WORLD FEDERATION C, P141
   Zhang Y, 2018, SUPPORT CARE CANCER, V26, P415, DOI 10.1007/s00520-017-3955-6
   Zhang YZ, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.646315
   Zheng Y, 2014, J Liaoning Univ Tradit Chin Med, V16, P152, DOI [10.13194/j.issn.1673-842x.2014.01.055, DOI 10.13194/J.ISSN.1673-842X.2014.01.055]
   Zhou H.Y., 2017, STUDY META ANAL ACUP
   Zhuang LP, 2013, INTEGR CANCER THER, V12, P197, DOI 10.1177/1534735412451321
NR 80
TC 50
Z9 65
U1 7
U2 87
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD NOV
PY 2022
VL 106
AR 154430
DI 10.1016/j.phymed.2022.154430
EA SEP 2022
PG 20
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 5A9YC
UT WOS:000863233400003
PM 36099656
DA 2026-01-16
ER

PT J
AU Kako, J
   Kajiwara, K
   Kobayashi, M
AF Kako, Jun
   Kajiwara, Kohei
   Kobayashi, Masamitsu
TI Could acupuncture be a treatment option for cancer patients with
   attitudinal barriers to pharmacological pain management?
SO SUPPORTIVE CARE IN CANCER
LA English
DT Letter
C1 [Kako, Jun] Hiroshima Univ, Div Nursing Sci, Grad Sch Biomed & Hlth Sci, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
   [Kajiwara, Kohei] Japanese Red Cross Kyushu Int Coll Nursing, Munakata, Japan.
   [Kobayashi, Masamitsu] Natl Def Med Coll, Fac Nursing, Tokorozawa, Saitama, Japan.
C3 Hiroshima University; National Defense Medical College - Japan
RP Kako, J (corresponding author), Hiroshima Univ, Div Nursing Sci, Grad Sch Biomed & Hlth Sci, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
EM jkako-tky@umin.ac.jp
RI Kajiwara, Kohei/D-3711-2019; Kako, Jun/G-2855-2019
OI Kajiwara, Kohei/0000-0001-5470-2209; Kobayashi,
   Masamitsu/0000-0001-8861-1778; Kako, Jun/0000-0001-6875-6275
CR Folkman S, 1997, SOC SCI MED, V45, P1207, DOI 10.1016/S0277-9536(97)00040-3
   Liou KT, 2021, SUPPORT CARE CANCER, V29, P427, DOI 10.1007/s00520-020-05504-y
NR 2
TC 0
Z9 0
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JAN
PY 2021
VL 29
IS 1
BP 3
EP 3
DI 10.1007/s00520-020-05712-6
EA AUG 2020
PG 1
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA RI9WR
UT WOS:000562347600001
PM 32833095
DA 2026-01-16
ER

PT J
AU Konda, Y
AF Konda, Y.
TI Integrative approach to pain management in prostate cancer: a case
   report on scalp and auricular acupuncture
SO ANNALS OF ONCOLOGY
LA English
DT Meeting Abstract
C1 [Konda, Y.] Univ Indonesia, Med Acupuncture Study Program, Jakarta, Indonesia.
C3 University of Indonesia
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0923-7534
EI 1569-8041
J9 ANN ONCOL
JI Ann. Oncol.
PD OCT
PY 2025
VL 36
SU 3
MA P51-3
BP S1742
EP S1742
DI 10.1016/j.annonc.2025.08.353
PG 1
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA O1031
UT WOS:001632241300106
DA 2026-01-16
ER

PT J
AU Paley, CA
   Johnson, MI
AF Paley, Carole A.
   Johnson, Mark I.
TI Acupuncture for cancer-induced bone pain: a pilot study
SO ACUPUNCTURE IN MEDICINE
LA English
DT Letter
ID RAT MODEL; PATHOPHYSIOLOGY; INTERVENTIONS; MECHANISMS; BEHAVIOR; NEURONS
C1 [Paley, Carole A.] Airedale NHS Fdn Trust, Res Off, Steeton BD20 6TD, Keighley, England.
   [Paley, Carole A.; Johnson, Mark I.] Leeds Metropolitan Univ, Leeds LS1 3HE, W Yorkshire, England.
C3 Leeds Beckett University
RP Paley, CA (corresponding author), Airedale NHS Fdn Trust, Res Off, Skipton Rd, Steeton BD20 6TD, Keighley, England.
EM biodynamics.physiotherapy@tesco.net
RI Paley, Carole Anne/AAM-2469-2020
OI Paley, Carole Anne/0000-0002-6335-2666
CR Benedetti F, 2005, J NEUROSCI, V25, P10390, DOI 10.1523/JNEUROSCI.3458-05.2005
   Bennett MI, 2010, J PAIN, V11, P351, DOI 10.1016/j.jpain.2009.08.002
   Briggs M, 1999, J PAIN SYMPTOM MANAG, V18, P438, DOI 10.1016/S0885-3924(99)00092-5
   Coleman RE, 2001, CANCER TREAT REV, V27, P165, DOI 10.1053/ctrv.2000.0210
   Donovan-Rodriguez T, 2005, ANESTHESIOLOGY, V102, P132, DOI 10.1097/00000542-200501000-00022
   Evans CJ, 2004, PAIN, V112, P254, DOI 10.1016/j.pain.2004.09.005
   FILSHIE J, 1990, ACUPUNCT MED, V8, P38
   Gralow J, 2007, J PAIN SYMPTOM MANAG, V33, P462, DOI 10.1016/j.jpainsymman.2007.01.001
   HAN JS, 1986, ASIAN PACIFIC J PHAR, V1, P7
   Kawakita K., 2006, Acupuncture in Medicine, V24, P58
   Lee H, 2005, EUR J PAIN, V9, P437, DOI 10.1016/j.ejpain.2004.10.004
   MacPherson H, 2010, ACUPUNCT MED, V28, P83, DOI 10.1136/aim.2009.001370
   OKEN MM, 1982, AM J CLIN ONCOL-CANC, V5, P649, DOI 10.1097/00000421-198212000-00014
   Paley C. A., 2011, ACUPUNCTURE CANC PAI
   PALEY CA, 2010, ECAM ADV ACCESS
   Pariente J, 2005, NEUROIMAGE, V25, P1161, DOI 10.1016/j.neuroimage.2005.01.016
   Paterson C, 2005, BMJ-BRIT MED J, V330, P1202, DOI 10.1136/bmj.330.7501.1202
   Petrut B, 2008, CURR ONCOL, V15, pS50, DOI 10.3747/co.v15i0.205
   Sandkühler J, 2000, PROG PAIN RES MANAG, V16, P359
   Sandkuhler J, 1997, J NEUROSCI, V17, P6483
   Sandkühler J, 2000, PAIN, V88, P113, DOI 10.1016/S0304-3959(00)00424-3
   Sevcik MA, 2005, PAIN, V115, P128, DOI 10.1016/j.pain.2005.02.022
   Thompson JW, 2005, OXFORD TXB PALLIATIV, P421
   Urch CE, 2005, J PAIN, V6, P837, DOI 10.1016/j.jpain.2005.08.005
   Urch CE, 2003, PAIN, V106, P347, DOI 10.1016/j.pain.2003.08.002
   White A, 2008, ACUPUNCT MED, V26, P111, DOI 10.1136/aim.26.2.111
NR 26
TC 3
Z9 4
U1 0
U2 10
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-5284
J9 ACUPUNCT MED
JI Acupunct. Med.
PD MAR
PY 2011
VL 29
IS 1
DI 10.1136/aim.2010.003087
PG 3
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 744FN
UT WOS:000289080400017
PM 21297175
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Romero, SAD
   Baser, RE
   Wong, GT
   Xiao, H
   Deng, GRY
   Mo, ZL
   Walker, D
   Macleod, JE
   Li, QS
   Barton-Burke, M
   Panageas, K
   Farrar, JT
   Epstein, AS
AF Mao, Jun J.
   Romero, Sally A. D.
   Baser, Raymond E.
   Wong, Greta
   Xiao, Han
   Deng, Gary
   Mo, Zunli
   Walker, Desiree
   Macleod, Jodi Elizabeth
   Li, Qing Susan
   Barton-Burke, Margaret
   Panageas, Katherine
   Farrar, John T.
   Epstein, Andrew S.
TI Acupuncture versus massage for pain in patients living with advanced
   cancer: The IMPACT randomized clinical trial.
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
C1 Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY USA.
   Mem Sloan Kettering Canc Ctr, New York, NY USA.
   Univ Calif San Diego, La Jolla, CA USA.
   Mem Sloan Kettering Canc Ctr, Basking Ridge New Jersey, Basking Ridge, NJ USA.
   Miami Canc Inst, Miami, FL USA.
   Univ Penn, Philadelphia, PA USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; University of California System; University of California San
   Diego; Memorial Sloan Kettering Cancer Center; University of
   Pennsylvania
RI Farrar, John/AAP-4788-2021
FU Patient-Centered Outcomes Research Institute (PCORI); U.S. National
   Institutes of Health
FX Patient-Centered Outcomes Research Institute (PCORI); U.S. National
   Institutes of Health.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD JUN 1
PY 2023
VL 41
IS 16_SUPPL
SU 16_SUPPL
AR 12101
DI 10.1200/JCO.2023.41.16_suppl.12101
PG 1
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 6KK9C
UT WOS:001555475400019
DA 2026-01-16
ER

PT J
AU Eccleston, C
   Fisher, E
   Thomas, KH
   Hearn, L
   Derry, S
   Stannard, C
   Knaggs, R
   Moore, RA
AF Eccleston, Christopher
   Fisher, Emma
   Thomas, Kyla H.
   Hearn, Leslie
   Derry, Sheena
   Stannard, Cathy
   Knaggs, Roger
   Moore, R. Andrew
TI Interventions for the reduction of prescribed opioid use in chronic
   non-cancer pain
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Analgesics, Opioid [*administration & dosage]; Chronic Pain [drug
   therapy; etiology; *therapy]; Cognitive Therapy [*methods]; Drug
   Tolerance; Electroacupuncture [*methods]; Observational Studies as
   Topic; Randomized Controlled Trials as Topic; Therapy, Computer-Assisted
   [methods]; Humans
ID LOW-BACK-PAIN; TREATMENT OUTCOMES; EXTENDED-RELEASE; ANALGESIC
   MEDICATION; UNITED-STATES; OLDER-ADULTS; DOUBLE-BLIND; EFFICACY;
   REHABILITATION; WITHDRAWAL
AB Background
   This is the first update of the original Cochrane Review published in 2013. The conclusions of this review have not changed from the 2013 publication. People with chronic non-cancer pain who are prescribed and are taking opioids can have a history of long-term, high-dose opioid use without effective pain relief. In those without good pain relief, reduction of prescribed opioid dose may be the desired and shared goal of both patient and clinician. Simple, unsupervised reduction of opioid use is clinically challenging, and very difficult to achieve and maintain.
   Objectives
   To investigate the effectiveness of different methods designed to achieve reduction or cessation of prescribed opioid use for the management of chronic non-cancer pain in adults compared to controls.
   Search methods
   For this update we searched CENTRAL, MEDLINE, and Embase in January 2017, as well as bibliographies and citation searches of included studies. We also searched one trial registry for ongoing trials.
   Selection criteria
   Included studies had to be randomised controlled trials comparing opioid users receiving an intervention with a control group receiving treatment as usual, active control, or placebo. The aim of the study had to include a treatment goal of dose reduction or cessation of opioid medication.
   Data collection and analysis
   Two review authors independently extracted data and assessed risk of bias. We sought data relating to prescribed opioid use, adverse events of opioid reduction, pain, and psychological and physical function. We planned to assess the certainty of the evidence using the GRADE approach, however, due to the heterogeneity of studies, we were unable to combine outcomes in a meta-analysis and therefore we did not assess the evidence with GRADE.
   Main results
   Three studies are new to this update, resulting in five included studies in total (278 participants). Participants were primarily women (mean age 49.63 years, SD = 11.74) with different chronic pain conditions. We judged the studies too heterogeneous to pool data in a meta-analysis, so we have summarised the results from each study qualitatively. The studies included acupuncture, mindfulness, and cognitive behavioral therapy interventions aimed at reducing opioid consumption, misuse of opioids, or maintenance of chronic pain management treatments. We found mixed results from the studies. Three of the five studies reported opioid consumption at posttreatment and follow-up. Two studies that delivered 'Mindfulness-Oriented Recovery Enhancement' or 'Therapeutic Interactive Voice Response' found a significant difference between groups at post-treatment and follow-up in opioid consumption. The remaining study found reduction in opioid consumption in both treatment and control groups, and between-group differences were not significant. Three studies reported adverse events related to the study and two studies did not have study-related adverse events. We also found mixed findings for pain intensity and physical functioning. The interventions did not show between-group differences for psychological functioning across all studies. Overall, the risk of bias was mixed across studies. All studies included sample sizes of fewer than 100 and so we judged all studies as high risk of bias for that category.
   Authors' conclusions
   There is no evidence for the efficacy or safety of methods for reducing prescribed opioid use in chronic pain. There is a small number of randomised controlled trials investigating opioid reduction, which means our conclusions are limited regarding the benefit of psychological, pharmacological, or other types of interventions for people with chronic pain trying to reduce their opioid consumption. The findings to date are mixed: there were reductions in opioid consumption after intervention, and often in control groups too.
C1 [Eccleston, Christopher] Univ Bath, Ctr Pain Res, Bath, Avon, England.
   [Fisher, Emma] Seattle Childrens Res Inst, Ctr Child Hlth Behav & Dev, Seattle, WA USA.
   [Thomas, Kyla H.] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
   [Hearn, Leslie; Derry, Sheena; Moore, R. Andrew] Univ Oxford, Pain Res, Nuffield Div Anaesthet, Oxford, England.
   [Hearn, Leslie; Derry, Sheena; Moore, R. Andrew] Univ Oxford, Nuffield Dept Clin Neurosci, Nuffield Div Anaesthet, Oxford, England.
   [Stannard, Cathy] Frenchay Hosp, Macmillan Ctr, Pain Clin, Bristol, Avon, England.
   [Knaggs, Roger] Univ Nottingham, Sch Pharm, Nottingham, England.
C3 University of Bath; Seattle Children's Hospital; University of Bristol;
   University of Oxford; University of Oxford; University of Nottingham
RP Eccleston, C (corresponding author), Univ Bath, Ctr Pain Res, Bath, Avon, England.
EM papas@bath.ac.uk
RI Fisher, Emma/AHC-6849-2022; Eccleston, Christopher/KIC-3638-2024
OI Fisher, Emma/0000-0001-8980-3181; Eccleston,
   Christopher/0000-0003-0698-1543; Thomas, Kyla/0000-0001-5418-4034
FU Oxford Pain Relief Trust, UK; Academy of Medical Sciences (AMS)
   [AMS-SGCL12-Thomas] Funding Source: researchfish; Engineering and
   Physical Sciences Research Council [EP/G012067/1] Funding Source:
   researchfish; National Institute for Health Research [CL-2013-25-003,
   13/89/29] Funding Source: researchfish; EPSRC [EP/G012067/1] Funding
   Source: UKRI
FX Internal sources Oxford Pain Relief Trust, UK. Institutional support
CR Amato L, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005031.pub4
   [Anonymous], COCHRANE HDB SYSTEMA
   [Anonymous], SYSTEMATIC REV PAIN
   [Anonymous], PAIN REHABILITATION
   [Anonymous], MINDFULNESS ORIENTED
   [Anonymous], INT EV WASH STAT INT
   [Anonymous], 2019, OP THER GUID ADH REP
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], REV MAN 5 REVM 5 VER
   [Anonymous], BEHAV INTERVENTIONS
   Atluri S, 2012, PAIN PHYSICIAN, V15, pES177
   Ballantyne JC, 2003, NEW ENGL J MED, V349, P1943, DOI 10.1056/NEJMra025411
   Benyamin R, 2008, PAIN PHYSICIAN, V11, pS105
   Braden JB, 2010, ARCH INTERN MED, V170, P1425, DOI 10.1001/archinternmed.2010.273
   Chou R, 2015, ANN INTERN MED, V162, P276, DOI 10.7326/M14-2559
   Chou R, 2009, J PAIN, V10, P113, DOI 10.1016/j.jpain.2008.10.008
   Crisostomo RA, 2008, AM J PHYS MED REHAB, V87, P527, DOI 10.1097/PHM.0b013e31817c124f
   Darchuk KM, 2010, PAIN MED, V11, P1352, DOI 10.1111/j.1526-4637.2010.00937.x
   Dowell D, 2016, JAMA-J AM MED ASSOC, V315, P1624, DOI 10.1001/jama.2016.1464
   Franklin GM, 2012, AM J IND MED, V55, P325, DOI 10.1002/ajim.21998
   Furlan AD, 2006, CAN MED ASSOC J, V174, P1589, DOI 10.1503/cmaj.051528
   Gallagher AM, 2009, CLIN THER, V31, P1707, DOI 10.1016/j.clinthera.2009.08.022
   Garland EL, 2014, J CONSULT CLIN PSYCH, V82, P448, DOI 10.1037/a0035798
   Gowing L, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002022.pub3
   Gowing L, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002021.pub3
   Guy GP Jr, 2017, MMWR-MORBID MORTAL W, V66, P697, DOI 10.15585/mmwr.mm6626a4
   Hale ME, 2007, J PAIN, V8, P175, DOI 10.1016/j.jpain.2006.09.011
   Higgins JP., 2011, COCHRANE HDB SYSTEMA, DOI DOI 10.1007/S12119-019-09598-3
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Hooten WM, 2007, PAIN MED, V8, P8, DOI 10.1111/j.1526-4637.2007.00253.x
   Hooten WM, 2009, ANESTH ANALG, V108, P308, DOI 10.1213/ane.0b013e31818c7b99
   Jamison RN, 2010, PAIN, V150, P390, DOI 10.1016/j.pain.2010.02.033
   Kalso E, 2004, PAIN, V112, P372, DOI 10.1016/j.pain.2004.09.019
   Krymchantowski AV, 2003, CEPHALALGIA, V23, P982, DOI 10.1046/j.1468-2982.2003.00648.x
   Manchikanti L, 2012, PAIN PHYSICIAN, V15, pS1
   Miller M, 2011, J AM GERIATR SOC, V59, P430, DOI 10.1111/j.1532-5415.2011.03318.x
   Moore RA, 2012, PAIN, V153, P265, DOI 10.1016/j.pain.2011.10.004
   Moore RA, 2005, ARTHRITIS RES THER, V7, pR1046, DOI 10.1186/ar1782
   Moore RA, 2014, PAIN PRACT, V14, P79, DOI 10.1111/papr.12050
   Morasco BJ, 2010, PAIN, V151, P625, DOI 10.1016/j.pain.2010.08.002
   Naylor MR, 2008, PAIN, V134, P335, DOI 10.1016/j.pain.2007.11.001
   Naylor MR, 2010, J PAIN, V11, P1410, DOI 10.1016/j.jpain.2010.03.019
   Noble M, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006605.pub2
   Paulozzi Leonard J., 2011, Morbidity and Mortality Weekly Report, V60, P1487
   Potter JS, 2010, J SUBST ABUSE TREAT, V38, pS80, DOI 10.1016/j.jsat.2009.12.007
   Roland CL, 2011, POSTGRAD MED, V123, P148, DOI 10.3810/pgm.2011.07.2314
   Siegfried N, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003362.pub2
   Solomon DH, 2010, ARCH INTERN MED, V170, P1968, DOI 10.1001/archinternmed.2010.391
   Stannard C, 2012, BRIT J PAIN, V6, P7, DOI 10.1177/2049463712439131
   Steiner DJ, 2011, J PAIN SYMPTOM MANAG, V42, P903, DOI 10.1016/j.jpainsymman.2011.04.006
   Sullivan MD, 2017, J PAIN, V18, P308, DOI 10.1016/j.jpain.2016.11.003
   Sullivan MD, 2010, PAIN, V150, P332, DOI 10.1016/j.pain.2010.05.020
   Townsend CO, 2008, PAIN, V140, P177, DOI 10.1016/j.pain.2008.08.005
   Weinstein SM, 2006, CLIN THER, V28, P86, DOI 10.1016/j.clinthera.2006.01.010
   Windmill J, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010323.pub2
   Zheng Z, 2008, EUR J PAIN, V12, P671, DOI 10.1016/j.ejpain.2007.10.003
NR 56
TC 122
Z9 131
U1 1
U2 33
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2017
IS 11
AR CD010323
DI 10.1002/14651858.CD010323.pub3
PG 35
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FO6NV
UT WOS:000416982300065
PM 29130474
OA Green Submitted, Green Published, Bronze
DA 2026-01-16
ER

PT J
AU Chen, HY
   So, TH
   Cho, WCS
   Qin, ZS
   Ma, CH
   Li, SG
   Yang, ZJ
   Jiang, F
   Wu, JM
   Zhang, ZJ
   Kong, FM
   Lao, LX
AF Chen, Haiyong
   So, Tsz Him
   Cho, William Chi-Shing
   Qin, Zongshi
   Ma, Chun Ho
   Li, Shi Guang
   Yang, Zhenjiang
   Jiang, Fei
   Wu, Junmei
   Zhang, Zhang Jin
   Kong, Feng Ming
   Lao, Lixing
TI The Adjunctive Effect of Acupuncture for Advanced Cancer Patients in a
   Collaborative Model of Palliative Care: Study Protocol for a 3-Arm
   Randomized Trial
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; cancer related symptoms; palliative care; quality of life;
   randomized controlled trial
ID SYMPTOMS; INSOMNIA; VALIDATION; FATIGUE; VERSION; TRENDS; SCALE; PAIN
AB Background: Cancer is the second leading cause of death before the age of 70. Improved cancer survival has put increasing demands on cancer care. Palliative care is the specialized multi-disciplinary care providing relief from the pain, symptoms, and stress of serious illness. The study aims to evaluate the adjunctive effect of acupuncture for advanced cancer patients in a collaborative model of palliative care. Methods/Design: This is a single-blinded, randomized, sham-controlled trial. One hundred twenty advanced cancer patients undergoing palliative care will be randomized in a ratio of 2: 1:1 to manual acupuncture plus standard care group (ASC), sham acupuncture plus standard care group (SSC), and standard care group (SC). Patients in ASC and SSC will receive 9 sessions of acupuncture or sham acupuncture for 3 weeks, and will be followed up for 2 months. The primary measure is the change from baseline score of the Edmonton Symptom Assessment System at 3 weeks. The secondary measures include the Brief Fatigue Inventory, Hospital Anxiety and Depression Scale, Insomnia Severity Index, Numeric Rating Scale, and European Organization for Research and Treatment of Cancer Quality of Life 15 items Questionnaire for Palliative Care. Discussion: The finding of this trial will provide high-quality evidence on the adjunctive effect of acupuncture to standard care on advanced cancer patients undergoing palliative care.
C1 [Chen, Haiyong; So, Tsz Him; Qin, Zongshi; Wu, Junmei; Zhang, Zhang Jin; Lao, Lixing] Univ Hong Kong, Sch Chinese Med, Pokfulam, 10 Sassoon Rd, Hong Kong, Peoples R China.
   [Cho, William Chi-Shing; Kong, Feng Ming] Queen Elizabeth Hosp, Hong Kong, Peoples R China.
   [Ma, Chun Ho] Univ Hong Kong, Clin Ctr Teaching & Res Chinese Med Aberdeen, Hong Kong, Peoples R China.
   [Li, Shi Guang; Yang, Zhenjiang] Shen Zhen Hosp Tradit Chinese Med, Shenzhen, Peoples R China.
   [Jiang, Fei] Univ Calif San Francisco, San Francisco, CA USA.
   [Lao, Lixing] Virginia Univ Integrat Med, Fairfax, VA USA.
C3 University of Hong Kong; Queen Elizabeth Hospital - Hong Kong;
   University of Hong Kong; University of California System; University of
   California San Francisco
RP Chen, HY (corresponding author), Univ Hong Kong, Sch Chinese Med, Pokfulam, 10 Sassoon Rd, Hong Kong, Peoples R China.
EM haiyong@hku.hk
RI Cho, William/H-7429-2019; So, Tsz-him/U-1240-2019; Lao,
   Lixing/P-9107-2019; ZHANG, ZHANG-JIN/ORK-0709-2025; Qin,
   Zongshi/ABE-2821-2021; CHEN, Haiyong/G-6787-2014
OI Qin, Zongshi/0000-0001-5888-461X; CHEN, Haiyong/0000-0002-4889-2752
FU Health and Medical Research Fund (HMRF), Food and Health Bureau, Hong
   Kong SAR Government [17181831]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Health and Medical Research Fund (HMRF), Food and
   Health Bureau, Hong Kong SAR Government (ref. 17181831). The funding
   plays no role in study design, collection, management, analysis,
   interpretation of data, writing of the report, or the decision to submit
   the report for publication.
CR Allemani C, 2018, LANCET, V391, P1023, DOI 10.1016/S0140-6736(17)33326-3
   [Anonymous], 2017, Strategic service framework for rehabilitation services
   Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21609, 10.3322/caac.21492]
   Brierley J., 2017, TNM CLASSIFICATION M
   Bruera E, 2012, ONCOLOGIST, V17, P267, DOI 10.1634/theoncologist.2011-0219
   Chen HY, 2007, J ALTERN COMPLEM MED, V13, P669, DOI 10.1089/acm.2006.6400
   Chen HY, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-362
   Chen HY, 2019, AM J CHINESE MED, V47, P1, DOI 10.1142/S0192415X19500010
   Cheng CS, 2017, SUPPORT CARE CANCER, V25, P3807, DOI 10.1007/s00520-017-3812-7
   Chung KF, 2011, SLEEP MED, V12, P463, DOI 10.1016/j.sleep.2010.09.019
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Fitzmaurice C, 2017, JAMA ONCOL, V3, P524, DOI [10.1001/jamaoncol.2016.5688, 10.1001/jamaoncol.2018.2706]
   Hashim D, 2016, ANN ONCOL, V27, P926, DOI 10.1093/annonc/mdw027
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Khan SA, 2014, NAT REV CLIN ONCOL, V11, P100, DOI 10.1038/nrclinonc.2013.217
   Kramer S, 2017, J ACUPUNCT MERIDIAN, V10, P294, DOI 10.1016/j.jams.2017.04.004
   Leung CM, 1999, ACTA PSYCHIAT SCAND, V100, P456, DOI 10.1111/j.1600-0447.1999.tb10897.x
   Lopez G, 2018, J CANCER, V9, P3613, DOI 10.7150/jca.26527
   Lund Irene, 2006, Acupunct Med, V24, P13
   Lundeberg T, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nep049
   MacPherson H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093739
   Noone AM HN., 2017, SEER CANC STAT REV 1
   Quaresma M, 2015, LANCET, V385, P1206, DOI 10.1016/S0140-6736(14)61396-9
   Quirico PE, 2007, Teaching Atlas of Acupuncture: Channels and Points, V1
   Romeo MJ, 2015, EXPLORE-NY, V11, P357, DOI 10.1016/j.explore.2015.06.001
   Schroeder K, 2018, ASIA-PAC J ONCOL NUR, V5, P4, DOI 10.4103/apjon.apjon_43_17
   Streitberger K, 1998, LANCET, V352, P364, DOI 10.1016/S0140-6736(97)10471-8
   Swami M, 2018, ONCOLOGY-NY, V32, P180
   Temel JS, 2010, NEW ENGL J MED, V363, P733, DOI 10.1056/NEJMoa1000678
   Towler P, 2013, SUPPORT CARE CANCER, V21, P2913, DOI 10.1007/s00520-013-1882-8
   Vas J, 2006, PAIN, V126, P245, DOI 10.1016/j.pain.2006.07.002
   Wang XS, 2004, J PAIN SYMPTOM MANAG, V27, P322, DOI 10.1016/j.jpainsymman.2003.09.008
   Wu XY, 2015, SCI REP-UK, V5, DOI 10.1038/srep16776
   Xie CC, 2013, Evid Based Complement Alternat Med, V2013
   Yeung WF, 2018, J SLEEP RES, V27, P220, DOI 10.1111/jsr.12597
   Zhang L, 2016, PALLIATIVE MED, V30, P401, DOI 10.1177/0269216315593671
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 37
TC 2
Z9 3
U1 1
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2021
VL 20
DI 10.1177/15347354211012749
PG 10
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA VN9HT
UT WOS:001255333400001
PM 33957783
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, XQ
   Duan, PB
   Zheng, M
   Xu, Q
   Yang, LH
   Wang, AQ
AF Wang, Xiao-Qing
   Duan, Pei-Bei
   Zheng, Man
   Xu, Qian
   Yang, Li-Hua
   Wang, A-Qin
TI Perioperative auricular acupuncture technique via intradermal needling
   buried for postoperative movement-evoked pain after open radical
   gastrectomy: Study protocol for a pilot randomized controlled trial
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Gastric cancer; Movement-evoked pain; Auricular acupuncture; Intradermal
   needling; Study protocol; Randomized controlled trial
ID ADVERSE EVENTS; GASTRIC-CANCER; RISK-FACTORS; MANAGEMENT; SURGERY;
   QUALITY
AB Introduction: Auricular acupuncture has been used for pain management but a more recent technique which buries an intradermal needle into the skin may provide longer lasting stimulation and enhance analgesia. The purpose of this study was to evaluate the efficacy and feasibility of perioperative auricular acupuncture technique via intradermal needling buried on postoperative movement-evoked pain reduction in patients with advanced gastric cancer following open radical gastrectomy.
   Methods: This research is a protocol for a prospective, assessor- and analyst-blinded, randomized controlled pilot trial with two parallel groups. Forty patients who undergo elective open radical gastrectomy will be recruited from 210-bed oncology surgery ward at a 2500-bed medical center between 2019/8/23 and 2020/2/20. Patients will be randomized to either the control group receiving non-invasive sham auricular acupuncture or to the experimental group receiving auricular acupuncture technique via intradermal needling buried, delivered 24 h before surgery and retained & replaced every 3 days for 6 consecutive days. A standard general anesthetic technique will be used for both groups. Rescue analgesia will be given when the VAS score is >= 4. Primary outcome measures are Functional Activity Score (FAS) and Numerical Rating Scale score (NRS) for movementevoked pain. Secondary outcome measures are NRS score for pain at rest, use of rescues analgesic, total opioid consumption, postoperative nausea and vomiting, physiological recovery Outcomes, Quality of Recovery-9 (QoR-9) and patient's satisfaction.
   Ethics and dissemination: This protocol has been approved by the Institutional Review Board (IRB) of the Clinical Research Centre (Affiliated Hospital of Nanjing University of Chinese Medicine, IRB No. 2019NL-032-02). In addition, the results of the preliminary study will be disseminated through peer-reviewed publications.
C1 [Wang, Xiao-Qing; Zheng, Man; Xu, Qian] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Anesthesiol & Pain Med, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
   [Duan, Pei-Bei] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Nursing, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
   [Yang, Li-Hua] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Oncol, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
   [Wang, A-Qin] Nanjing Univ Chinese Med, Sch Nursing, 138 Xianlin Rd, Nanjing 210046, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine; Nanjing University of
   Chinese Medicine
RP Zheng, M (corresponding author), Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Anesthesiol & Pain Med, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.; Duan, PB (corresponding author), Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Nursing, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
EM wangxiaoqing319@126.com; dpb_58@163.com; man_zheng@sina.com;
   xuqian36@126.com; yanglihua17@sina.com; 1078651915@qq.com
FU Affiliated Hospital of Nanjing University of Chinese Medicine [Y19074]
FX This study was supported by a research grant from Affiliated Hospital of
   Nanjing University of Chinese Medicine (Y19074).
CR [Anonymous], AC PAIN MAN MEAS TOO
   [Anonymous], EVID COMPLEMENT ALTE
   [Anonymous], 2005, Acute pain management performance measurement toolkit
   Argoff CE, 2014, PAIN PRACT, V14, P477, DOI 10.1111/papr.12108
   Asher GN, 2010, J ALTERN COMPLEM MED, V16, P1097, DOI 10.1089/acm.2009.0451
   Bang YJ, 2012, LANCET, V379, P315, DOI 10.1016/S0140-6736(11)61873-4
   Beloeil H, 2016, J VISC SURG, V153, pS15, DOI [10.1016/j.jchirv.2016.09.003, 10.1016/j.jviscsurg.2016.09.004]
   Bijur PE, 2003, ACAD EMERG MED, V10, P390, DOI 10.1197/aemj.10.4.390
   Boutron I, 2008, ANN INTERN MED, V148, P295, DOI 10.7326/0003-4819-148-4-200802190-00008
   Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21609, 10.3322/caac.21492]
   Breivik H, 2008, BRIT J ANAESTH, V101, P17, DOI 10.1093/bja/aen103
   Chan MTV, 2008, ANESTH ANALG, V107, P1189, DOI 10.1213/ane.0b013e318184b94e
   Chen W Q, 2018, Zhonghua Zhong Liu Za Zhi, V40, P5, DOI 10.3760/cma.j.issn.0253-3766.2018.01.002
   Chung KF, 2015, CLIN J PAIN, V31, P922, DOI 10.1097/AJP.0000000000000189
   Chung KF, 2014, ACUPUNCT MED, V32, P455, DOI 10.1136/acupmed-2014-010635
   Devin CJ, 2015, J CLIN NEUROSCI, V22, P930, DOI 10.1016/j.jocn.2015.01.003
   Dowell Deborah, 2016, JAMA, V315, P1624, DOI [10.15585/mmwr.rr6501e1, 10.1001/jama.2016.1464]
   Emanuel EJ, 2013, LANCET, V381, P1532, DOI 10.1016/S0140-6736(13)60970-8
   Coura LEF, 2011, ACUPUNCT MED, V29, P16, DOI 10.1136/aim.2010.003251
   Ferlay J, 2019, INT J CANCER, V144, P1941, DOI 10.1002/ijc.31937
   Ferlay J, 2015, INT J CANCER, V136, pE359, DOI [10.14343/jcscr.2016.4e1003, 10.1002/ijc.29210]
   Fletcher D, 2008, PAIN, V137, P441, DOI 10.1016/j.pain.2008.02.026
   Furuse N, 2017, MED ACUPUNCT, V29, P155, DOI 10.1089/acu.2017.1230
   Gerbershagen HJ, 2014, ANESTHESIOLOGY, V120, P1237, DOI 10.1097/ALN.0000000000000108
   Gerbershagen HJ, 2013, ANESTHESIOLOGY, V118, P934, DOI 10.1097/ALN.0b013e31828866b3
   Hamashima C, 2014, WORLD J GASTROENTERO, V20, P13767, DOI 10.3748/wjg.v20.i38.13767
   Hawker GA, 2011, ARTHRIT CARE RES, V63, pS240, DOI 10.1002/acr.20543
   Holzer A, 2011, MINERVA ANESTESIOL, V77, P298
   Karimi P, 2014, CANCER EPIDEM BIOMAR, V23, P700, DOI 10.1158/1055-9965.EPI-13-1057
   Kehlet H, 2006, LANCET, V367, P1618, DOI 10.1016/S0140-6736(06)68700-X
   Khalili G, 2013, J CLIN ANESTH, V25, P188, DOI 10.1016/j.jclinane.2012.09.004
   Lorenz KA, 2009, J AM BOARD FAM MED, V22, P291, DOI 10.3122/jabfm.2009.03.080162
   MacPherson H, 2004, QUAL SAF HEALTH CARE, V13, P349, DOI 10.1136/qshc.2003.009134
   MacPherson Hugh, 2010, J Evid Based Med, V3, P140, DOI 10.1111/j.1756-5391.2010.01086.x
   Meissner W, 2017, DTSCH ARZTEBL INT, V114, P161, DOI 10.3238/arztebl.2017.0161
   Melchart D, 2004, ARCH INTERN MED, V164, P104, DOI 10.1001/archinte.164.1.104
   Miclescu A, 2017, SCAND J PAIN, V16, P204, DOI 10.1016/j.sjpain.2017.04.072
   Mitra S, 2018, CURR PAIN HEADACHE R, V22, DOI 10.1007/s11916-018-0690-8
   Nogier R, 2014, MED ACUPUNCT, V26, P76, DOI 10.1089/acu.2014.1035
   Radnovich R, 2014, POSTGRAD MED, V126, P59, DOI 10.3810/pgm.2014.07.2784
   Schug SA, 2016, MED J AUSTRALIA, V204, P315, DOI 10.5694/mja16.00133
   Srikandarajah S, 2011, PAIN, V152, P1734, DOI 10.1016/j.pain.2011.02.008
   Tan JY, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/506758
   Usichenko TI, 2008, ANAESTHESIA, V63, P1343, DOI 10.1111/j.1365-2044.2008.05632.x
   Vincent C., 1990, Complementary Medical Research, V4, P8
   Wan Lai-Siqi, 2013, Zhongguo Zhen Jiu, V33, P237
   White PF, 2010, ANESTHESIOLOGY, V112, P220, DOI 10.1097/ALN.0b013e3181c6316e
   Witt CM, 2009, FORSCH KOMPLEMENTMED, V16, P91, DOI 10.1159/000209315
   Yang XY, 2015, BRIT J ANAESTH, V115, P883, DOI 10.1093/bja/aev352
NR 49
TC 1
Z9 1
U1 1
U2 27
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD JAN
PY 2020
VL 33
AR 101034
DI 10.1016/j.eujim.2019.101034
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA LD6DP
UT WOS:000526121000024
DA 2026-01-16
ER

PT J
AU Dymackova, R
   Kazda, T
   Slavik, M
   Selingerova, I
   Slampa, P
   Slama, O
AF Dymackova, Radana
   Kazda, Tomas
   Slavik, Marek
   Selingerova, Iveta
   Slampa, Pavel
   Slama, Ondrej
TI Acupuncture in the treatment of acute toxicity during and after head and
   neck cancer radiotherapy: Interim analysis of randomized prospective
   open-label trial
SO BIOMEDICAL PAPERS-OLOMOUC
LA English
DT Article
DE acupuncture; head and neck; cancer; radiotherapy; toxicity
ID RADIATION-INDUCED XEROSTOMIA; PREVENTION
AB Aims. The aim of this investigator-initiated prospective randomized open-label single institutional trial is to evaluate the role of acupuncture in the treatment of acute skin and mucosal toxicity, xerostomia, and perception of taste, pain, and nausea related to curative and adjuvant (chemo)radiotherapy of head and neck cancer. This paper reports pilot data of the first 30 enrolled patients.
   Methods. Patients were randomized to undergo standard of care radiotherapy +/- chemotherapy and support care defined by our institutional standard operating procedures alone or in the combination with acupuncture which was initiated with the first signs of any toxicity.
   Results. Fifteen patients were enrolled in both arms and all finished the treatment as planned.The median pain was significantly lower in the acupuncture arm (median 1.6 points vs. 2.5 points on a 10-item Likert scale; P=0.035) as well as duration of acute pain (median 31 days vs. 54 days; P=0.031). Patients with acupuncture had significantly shorter duration of acute skin (median 44 days vs. 109 days; P<0.001) and mucosal toxicity (median 34 days vs. 109 days; P<0.001) with no difference in grading of toxicity (median grade 1.6 vs. 1.5; P=0.701 and median grade 1.4 vs. 1.6; P=0.204 for skin and mucosa, respectively). No significant difference was found for other toxicity domains, with the exception of salivation toxicity which was significantly lower in acupuncture arm (median grade 1.3 vs. 1.7; P=0.048).
   Conclusion. In this interim analysis, acupuncture leads to lower pain andfaster disappearance of skin and mucosal toxicity after (chemo)radiotherapy of head and neck cancer. Description and validation of acupuncture using scientific approaches will further enhance acceptance of this method by both patients and health care providers.
C1 [Dymackova, Radana; Kazda, Tomas; Slavik, Marek; Slampa, Pavel] Masaryk Univ, Fac Med, Dept Radiat Oncol, Kamenice 5, Brno 62500, Czech Republic.
   [Dymackova, Radana; Kazda, Tomas; Slavik, Marek; Slampa, Pavel] Masaryk Mem Canc Inst, Dept Radiat Oncol, Zluty Kopec 7, Brno 65653, Czech Republic.
   [Selingerova, Iveta] Masaryk Mem Canc Inst, Reg Ctr Appl Mol Oncol RECAMO, Zluty Kopec 7, Brno 65653, Czech Republic.
   [Slama, Ondrej] Masaryk Univ, Fac Med, Dept Comprehens Canc Care, Kamenice 5, Brno 62500, Czech Republic.
   [Slama, Ondrej] Masaryk Mem Canc Inst, Dept Comprehens Canc Care, Zluty Kopec 7, Brno 65653, Czech Republic.
C3 Masaryk University; Masaryk Memorial Cancer Institute; Masaryk Memorial
   Cancer Institute; Masaryk University; Masaryk Memorial Cancer Institute
RP Kazda, T (corresponding author), Masaryk Univ, Fac Med, Dept Radiat Oncol, Kamenice 5, Brno 62500, Czech Republic.; Kazda, T (corresponding author), Masaryk Mem Canc Inst, Dept Radiat Oncol, Zluty Kopec 7, Brno 65653, Czech Republic.
EM tomas.kazda@mou.cz
RI ; Selingerova, Iveta/AAF-6396-2019; Kazda, Tomas/AAQ-1740-2020; Slama,
   Onej/AGD-7993-2022
OI Slávik, Marek/0000-0002-8591-5941; Slama, Onej/0000-0001-9557-3204
FU Ministry of Health of the Czech Republic [15-33590A]; MH CZ-DRO (MMCI)
   [00209805]; project MSMT -NPU I [LO1413]
FX This work was supported by the Ministry of Health of the Czech Republic,
   [grant No. 15-33590A], MH CZ-DRO (MMCI, 00209805) and supported by
   project MSMT -NPU I -LO1413.
CR Brizhik L, 2019, J ACUPUNCT MERIDIAN, V12, P29, DOI 10.1016/j.jams.2018.06.009
   Chan ATC, 2012, ANN ONCOL, V23, P83, DOI 10.1093/annonc/mds266
   Chan MWC, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03272-0
   Dymackova R, 2014, Klin Onkol, V27, P291
   Braga FDF, 2011, BRAZ ORAL RES, V25, P180
   Gregoire V, 2010, ANN ONCOL, V21, pv184, DOI 10.1093/annonc/mdq185
   Meng ZQ, 2012, CANCER-AM CANCER SOC, V118, P3337, DOI 10.1002/cncr.26550
   Niu X, 2013, AFR J TRADIT COMPLEM, V10, P550, DOI 10.4314/ajtcam.v10i3.25
   Santuray RT, 2018, TRENDS CANCER, V4, P385, DOI 10.1016/j.trecan.2018.03.006
   Wang XP, 2018, J CANCER RES THER, V14, pS600, DOI 10.4103/0973-1482.183174
NR 10
TC 10
Z9 11
U1 0
U2 7
PU PALACKY UNIV, MEDICAL FAC
PI OLOMOUC
PA CENTRAL LIBRARY, HNEVOTINSKA 3, OLOMOUC, 00000, CZECH REPUBLIC
SN 1213-8118
EI 1804-7521
J9 BIOMED PAP
JI Biomed. Pap-Olomouc
PD DEC
PY 2020
VL 164
IS 4
BP 454
EP 460
DI 10.5507/bp.2020.021
PG 7
WC Engineering, Biomedical; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Research & Experimental Medicine
GA PO1ST
UT WOS:000604951200014
PM 32597419
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Chokshi, SK
   Ladas, EJ
   Taromina, K
   McDaniel, D
   Rooney, D
   Jin, ZZ
   Hsu, WC
   Kelly, KM
AF Chokshi, Sagar K.
   Ladas, Elena J.
   Taromina, Katherine
   McDaniel, Douglas
   Rooney, Diane
   Jin, Zhezhen
   Hsu, Wei-Chun
   Kelly, Kara M.
TI Predictors of acupuncture use among children and adolescents with cancer
SO PEDIATRIC BLOOD & CANCER
LA English
DT Article
DE acupuncture therapy; integrative medicine; pediatric oncology;
   supportive care
ID COMPLEMENTARY THERAPIES; ALTERNATIVE MEDICINE; PREVALENCE; SYMPTOMS;
   ONCOLOGY; SAFETY; CARE; DISTRESS; PATIENT; ADULTS
AB BackgroundEvidence for the application of acupuncture in pediatric oncology is limited. We investigated the acceptance of acupuncture and factors associated with its use among children and adolescents with cancer.
   MethodsNinety acupuncture-naive children receiving cancer treatment at Columbia University Medical Center (CUMC) provided consent/assent for participation. Participants could choose to receive or refuse integrative services offered at CUMC. Symptoms were collected for a 6-month period with the Memorial Symptom Assessment Scale (MSAS). Acute and delayed adverse events among participants who received acupuncture were recorded.
   ResultsFifty-four percent of the participants elected to receive acupuncture. In total, 252 acupuncture sessions were administered with a median of four sessions per patient (range 1-13 sessions). Pain (56%), nausea (51%), lack of energy (50%), and irritability (43%) were the most frequently reported symptoms in the whole cohort. Determinants of acupuncture use included older age and ethnicity. Acupuncture was more likely than other integrative modalities to be used for gastrointestinal and constitutional symptoms including drowsiness (odds ratio [OR], 3.34; 95% confidence interval [CI], 1.98-5.66; P < 0.0001), lack of energy (OR, 3.23; 95% CI, 1.78-5.87; P = 0.0001), and pain (OR, 2.63; 95% CI, 1.46-4.72; P = 0.001). Adverse events were reported by 3% of the participants. There was no increased incidence of adverse events in children with thrombocytopenia (P = 0.189) or neutropenia (P = 0.497).
   ConclusionOur results highlight the potential use of acupuncture as a safe, adjunctive therapy for symptom management within existing supportive care regimens in pediatric oncology and potential areas to focus research initiatives.
C1 [Chokshi, Sagar K.] Cooper Univ Hosp, Dept Obstet & Gynecol, Camden, NJ USA.
   [Ladas, Elena J.; Taromina, Katherine; McDaniel, Douglas; Rooney, Diane; Kelly, Kara M.] Columbia Univ, Med Ctr, Div Pediat Hematol Oncol & Stem Cell Transplant, New York, NY USA.
   [Ladas, Elena J.] Columbia Univ, Med Ctr, Inst Human Nutr, New York, NY USA.
   [Jin, Zhezhen] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY USA.
   [Hsu, Wei-Chun] Cornell Univ, Weill Cornell Med Coll, Dept Healthcare Policy & Res, New York, NY 10021 USA.
C3 Cooper University Hospital; Columbia University; Columbia University;
   Columbia University; Cornell University; Weill Cornell Medicine
RP Chokshi, SK (corresponding author), 3 Cooper Plaza,Suite 221, Camden, NJ 08103 USA.
EM chokshi-sagar@cooperhealth.edu
RI ; Jin, Zhezhen/GZG-6079-2022
OI Chokshi, Sagar/0000-0002-4221-2744; 
CR Adams D, 2011, PEDIATRICS, V128, pE1575, DOI 10.1542/peds.2011-1091
   [Anonymous], 2002, ACUPUNCTURE REV ANAL
   Baker JN, 2008, PEDIATR CLIN N AM, V55, P223, DOI 10.1016/j.pcl.2007.10.011
   Barnes PM, 2008, STAT NCFH COMPLEMENT
   Bishop FL, 2010, PEDIATRICS, V125, P768, DOI 10.1542/peds.2009-1775
   Black Lindsey I, 2015, Natl Health Stat Report, P1
   Bleyer WA, 2002, MED PEDIATR ONCOL, V38, P1, DOI 10.1002/mpo.1257
   Bluebond-Langner M, 2007, J CLIN ONCOL, V25, P2414, DOI 10.1200/JCO.2006.08.7759
   Brett J, 2015, CLEAN NEEDLE TECHNIQ
   Chao MT, 2006, J ALTERN COMPLEM MED, V12, P719, DOI 10.1089/acm.2006.12.719
   Cohen Andrea J, 2005, Integr Cancer Ther, V4, P131, DOI 10.1177/1534735405276419
   Collins JJ, 2000, J PAIN SYMPTOM MANAG, V19, P363, DOI 10.1016/S0885-3924(00)00127-5
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Deng G, 2005, CA-CANCER J CLIN, V55, P109, DOI 10.3322/canjclin.55.2.109
   Dyson GJ, 2012, SUPPORT CARE CANCER, V20, P75, DOI 10.1007/s00520-010-1059-7
   Ernst E, 1998, CANCER-AM CANCER SOC, V83, P777, DOI 10.1002/(SICI)1097-0142(19980815)83:4<777::AID-CNCR22>3.0.CO;2-O
   Ezzo JM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002285.pub2
   Freyer DR, 2013, PEDIATR BLOOD CANCER, V60, P1055, DOI 10.1002/pbc.24431
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Gottschling S, 2008, KLIN PADIATR, V220, P365, DOI 10.1055/s-0028-1086039
   Graham RE, 2005, J NATL MED ASSOC, V97, P535
   Hedstrom Mariann, 2003, J Pediatr Oncol Nurs, V20, P120
   Herman PM, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-001046
   Jindal V, 2008, J PEDIAT HEMATOL ONC, V30, P431, DOI 10.1097/MPH.0b013e318165b2cc
   Kelly Kara M, 2009, Hematology Am Soc Hematol Educ Program, P307, DOI 10.1182/asheducation-2009.1.307
   Kelly KM, 2000, J PEDIAT HEMATOL ONC, V22, P412, DOI 10.1097/00043426-200009000-00005
   Kemper KJ, 2000, PEDIATRICS, V105, P941
   Ladas EJ, 2006, J PEDIAT HEMATOL ONC, V28, P601, DOI 10.1097/01.mph.0000212989.26317.52
   Ladas EJ, 2010, SUPPORT CARE CANCER, V18, P1487, DOI 10.1007/s00520-010-0926-6
   Laengler A, 2008, EUR J CANCER, V44, P2233, DOI 10.1016/j.ejca.2008.07.020
   Martel D, 2005, PEDIATR BLOOD CANCER, V44, P660, DOI 10.1002/pbc.20205
   McDaniel D, 2016, MERIDIANS J ACUPUNCT, V3, P1
   Micozzi MarcS., 2006, FUNDAMENTALS COMPLEM
   Raith W, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/739414
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Söllner W, 2000, CANCER-AM CANCER SOC, V89, P873, DOI 10.1002/1097-0142(20000815)89:4<873::AID-CNCR21>3.0.CO;2-K
   White A, 2001, Acupunct Med, V19, P84
   Wolfe J, 2015, J CLIN ONCOL, V33, P1928, DOI 10.1200/JCO.2014.59.1222
   Zhukovsky DS, 2015, CANCER-AM CANCER SOC, V121, P4080, DOI 10.1002/cncr.29597
NR 39
TC 25
Z9 29
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1545-5009
EI 1545-5017
J9 PEDIATR BLOOD CANCER
JI Pediatr. Blood Cancer
PD JUL
PY 2017
VL 64
IS 7
AR e26424
DI 10.1002/pbc.26424
PG 7
WC Oncology; Hematology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Hematology; Pediatrics
GA EV8KE
UT WOS:000402028300034
PM 28176457
DA 2026-01-16
ER

PT J
AU Bauml, J
   Basal, C
   Mao, JJ
AF Bauml, Joshua
   Basal, Coby
   Mao, Jun J.
TI Treatment of post-mastectomy pain syndrome with acupuncture: a case
   report
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
ID BREAST-CANCER SURVIVORS; LONG-TERM; PREVALENCE; SURGERY; CARE
AB Post-mastectomy pain syndrome (PMPS) is a common and severe neuropathic pain syndrome arising after breast surgery. Since few effective allopathic treatments exist for PMPS, many patients may seek assistance from complementary and alternative medicine. Here, we report a case of a woman with severe and persistent PMPS who was successfully treated with acupuncture.
C1 [Bauml, Joshua] Univ Penn, Perelman Sch Med, Div Hematol Oncol, Philadelphia, PA 19104 USA.
   [Basal, Coby] Univ Penn, Philadelphia, PA 19104 USA.
   [Mao, Jun J.] Univ Penn, Perelman Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania
RP Mao, JJ (corresponding author), Univ Penn, Perelman Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA.
EM Jun.mao@uphs.upenn.edu
RI Mao, Jun/F-5009-2012
FU National Institutes of Health NCCAM [K23 AT004112]
FX JJM is a recipient of the National Institutes of Health NCCAM K23
   AT004112 award.
CR Abuaisha BB, 1998, DIABETES RES CLIN PR, V39, P115, DOI 10.1016/S0168-8227(97)00123-X
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Blunt C, 2004, PAIN, V108, P294, DOI 10.1016/j.pain.2003.12.011
   Carpenter JS, 1998, J CLIN EPIDEMIOL, V51, P1285, DOI 10.1016/S0895-4356(98)00121-8
   Cassileth BR, 2013, CANCER-AM CANCER SOC, V119, P2455, DOI 10.1002/cncr.28093
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Gärtner R, 2009, JAMA-J AM MED ASSOC, V302, P1985, DOI 10.1001/jama.2009.1568
   Macdonald L, 2005, BRIT J CANCER, V92, P225, DOI 10.1038/sj.bjc.6602304
   Mao Jun J, 2007, Acupunct Med, V25, P158
   Mao JJ, 2010, PRIMARY CARE, V37, P105, DOI 10.1016/j.pop.2009.09.010
   Melchart D, 2004, ARCH INTERN MED, V164, P104, DOI 10.1001/archinte.164.1.104
   Fabro EAN, 2012, BREAST, V21, P321, DOI 10.1016/j.breast.2012.01.019
   Siegel R, 2013, CA-CANCER J CLIN, V63, P11, DOI 10.3322/caac.21166
   Smith WCS, 1999, PAIN, V83, P91, DOI 10.1016/S0304-3959(99)00076-7
   Vilholm OJ, 2008, BRIT J CANCER, V99, P604, DOI 10.1038/sj.bjc.6604534
NR 15
TC 6
Z9 9
U1 0
U2 23
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD APR
PY 2014
VL 32
IS 2
BP 183
EP 185
DI 10.1136/acupmed-2013-010459
PG 3
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AE2WS
UT WOS:000333834600015
PM 24240772
DA 2026-01-16
ER

PT J
AU Fan, BK
   Xia, YF
   Feng, YY
   Yang, XL
   Lin, P
   Fang, JQ
   Zhang, ZY
   Li, SM
AF Fan, Binke
   Xia, Yunfan
   Feng, Yuanyuan
   Yang, Xilong
   Lin, Ping
   Fang, Jianqiao
   Zhang, Zuyong
   Li, Shimin
TI Research trends of acupuncture therapy for painful peripheral nervous
   system diseases from 2004 to 2023: a bibliometric and meta-analysis
SO FRONTIERS IN NEUROLOGY
LA English
DT Review
DE acupuncture therapy; peripheral nervous system diseases; pain
   management; peripheral neuropathy; bibliometric analysis; CiteSpace
ID POSTHERPETIC NEURALGIA; TRIGEMINAL NEURALGIA; INTEGRATIVE ONCOLOGY;
   PILOT TRIAL; NEUROPATHY; CHEMOTHERAPY; ELECTROACUPUNCTURE; MEDICINE;
   EFFICACY; SAFETY
AB Background Peripheral nervous system diseases (PNSD) have represented a major global health burden, leading to significant economic impacts and diminished productivity. This bibliometric analysis was performed to summarize the current research trends and hotspots over the past two decades, aiming to provide a comprehensive perspective for future research. Methods All data were sourced from the Web of Science Core Collection (WoSCC) on March 1, 2024, for publications between January 1, 2004, and December 31, 2023. Data visualization and analyses, including descriptive statistics, co-occurrence mapping, and cluster analysis, were performed using CiteSpace (Version 6.1.R6) and Excel 2021. Results Our search yielded 678 references, with the annual publication count demonstrating an increasing trend over the past 20 years. The most productive country and institution were China and Kyung Hee University, respectively. Fang Jianqiao, was the most prolific author with the highest publications. Among journals, "Pain," was the most frequently cited, while the top-cited reference was a randomized controlled pilot trial by Lu Weidong in 2020. "Acupuncture" emerged as the keyword with the highest frequency. The meta-analysis indicated that acupuncture was more effective than standard care for pain associated with Diabetic Peripheral Neuropathy [MD = -2.03, 95% CI (-2.86, -1.21), 2 RCTs, 102 participants, p < 0.0001]. Conclusion Our bibliometric review revealed key insights into the focal areas of PNSD research, underscoring the urgent need for continued and targeted high-quality investigations.
C1 [Fan, Binke; Lin, Ping; Zhang, Zuyong; Li, Shimin] Zhejiang Chinese Med Univ, Affiliated Hangzhou Hosp 3, Hangzhou, Zhejiang, Peoples R China.
   [Xia, Yunfan; Feng, Yuanyuan; Yang, Xilong; Fang, Jianqiao] Zhejiang Chinese Med Univ, Clin Med Coll 3, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical University
RP Zhang, ZY; Li, SM (corresponding author), Zhejiang Chinese Med Univ, Affiliated Hangzhou Hosp 3, Hangzhou, Zhejiang, Peoples R China.
EM 20168028@zcmu.edu.cn; lishimin004@126.com
RI L., Y./GRX-0926-2022; feng, yuanyuan/GRO-2896-2022
OI Lin, Ping/0000-0001-6247-738X
FU Medical and Health Science and Technology Program of Hangzhou
FX All of the authors involved in this study would like to extend their
   appreciation and gratitude to Prof. Chaomei Chen for inventing CiteSpace
   and opening the use of it.
CR Ang L, 2023, COMPLEMENT THER CLIN, V52, DOI 10.1016/j.ctcp.2023.101763
   Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Ben-Arye E, 2022, CANCER-AM CANCER SOC, V128, P3641, DOI 10.1002/cncr.34422
   Berman BM, 2004, ANN INTERN MED, V141, P901, DOI 10.7326/0003-4819-141-12-200412210-00006
   Brinkhaus B, 2013, ANN INTERN MED, V158, P225, DOI 10.7326/0003-4819-158-4-201302190-00002
   Chao MT, 2019, PAIN MED, V20, P2292, DOI 10.1093/pm/pnz117
   Chen DY, 2021, FRONT NEUROL, V12, DOI 10.3389/fneur.2021.637310
   Cheuk DKL, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005472.pub3
   Coyle ME, 2017, DERMATOL THER, V30, DOI 10.1111/dth.12468
   Cruccu G, 2008, EUR J NEUROL, V15, P1013, DOI 10.1111/j.1468-1331.2008.02185.x
   de Sousa TR, 2023, J CLIN NURS, V32, P6917, DOI 10.1111/jocn.16812
   Dietzel J, 2023, J CLIN MED, V12, DOI 10.3390/jcm12062103
   Dimitrova A, 2017, J ALTERN COMPLEM MED, V23, P164, DOI 10.1089/acm.2016.0155
   Finnerup NB, 2021, PHYSIOL REV, V101, P259, DOI 10.1152/physrev.00045.2019
   Gao J, 2019, J NERV MENT DIS, V207, P171, DOI 10.1097/NMD.0000000000000937
   Gao XM, 2023, J TRADIT CHIN MED, V43, P359, DOI 10.19852/j.cnki.jtcm.2023.02.007
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Goo B, 2023, J PAIN RES, V16, P623, DOI 10.2147/JPR.S396264
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   He KL, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/4478444
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hicks CW, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1212-8
   Hu HT, 2019, COMPLEMENT THER CLIN, V34, P254, DOI 10.1016/j.ctcp.2018.12.013
   Hu QM, 2020, J PAIN, V21, P1060, DOI 10.1016/j.jpain.2020.01.007
   Huang MC, 2023, ONCOLOGIST, V28, pE436, DOI 10.1093/oncolo/oyad065
   Hwang MS, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019837
   Ichida MC, 2017, CHIN J INTEGR MED, V23, P829, DOI 10.1007/s11655-017-2786-0
   Ju ZY, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012057.pub2
   Kong JT, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.22787
   Kutcher AM, 2022, WESTERN J NURS RES, V44, P169, DOI 10.1177/0193945921992538
   Lee JH, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000018830
   Li K, 2019, CURR ONCOL, V26, pE147, DOI 10.3747/co.26.4261
   Li XT, 2023, INTEGR CANCER THER, V22, DOI 10.1177/15347354221149992
   Li Y, 2021, CANCERS, V13, DOI 10.3390/cancers13040766
   Liu K, 2019, J PAIN RES, V12, P2359, DOI 10.2147/JPR.S210471
   Liu ZS, 2016, ANN INTERN MED, V165, P761, DOI 10.7326/M15-3118
   Lu C, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.843886
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Lu ZX, 2017, J ALTERN COMPLEM MED, V23, P964, DOI 10.1089/acm.2017.0052
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mao JJ, 2021, JAMA ONCOL, V7, P720, DOI 10.1001/jamaoncol.2021.0310
   Mezzanotte JN, 2022, CURR TREAT OPTION ON, V23, P29, DOI 10.1007/s11864-021-00926-0
   Molassiotis A, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419836501
   Nicolian S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0214195
   Papadopoulou M, 2023, IN VIVO, V37, P47, DOI 10.21873/invivo.13053
   Pei LX, 2023, ACUPUNCT MED, V41, P73, DOI 10.1177/09645284221076512
   Pei WY, 2019, J PAIN RES, V12, P2155, DOI 10.2147/JPR.S199950
   Qi T, 2022, ANN PALLIAT MED, V11, P756, DOI 10.21037/apm-22-109
   Rostock M, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/349653
   Ruengwongroj P, 2020, COMPLEMENT THER CLIN, V40, DOI 10.1016/j.ctcp.2020.101202
   Schröder S, 2007, EUR J NEUROL, V14, P276, DOI 10.1111/j.1468-1331.2006.01632.x
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Seo SY, 2017, AM J CHINESE MED, V45, P1573, DOI 10.1142/S0192415X17500859
   Smith TJ, 2023, NEW ENGL J MED, V389, P158, DOI 10.1056/NEJMra2110098
   Smith TJ, 2010, J PAIN SYMPTOM MANAG, V40, P883, DOI 10.1016/j.jpainsymman.2010.03.022
   Stringer J, 2022, EUR J ONCOL NURS, V60, DOI 10.1016/j.ejon.2022.102171
   Sun J, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019710
   Teng C, 2023, SUPPORT CARE CANCER, V31, DOI 10.1007/s00520-022-07463-y
   Ulett GA, 1998, BIOL PSYCHIAT, V44, P129, DOI 10.1016/S0006-3223(97)00394-6
   Ursini T, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-46
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Wang L, 2020, J TRADIT CHIN MED, V40, P121
   Wang Y, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011986
   Watson JC, 2015, MAYO CLIN PROC, V90, P940, DOI 10.1016/j.mayocp.2015.05.004
   Wu CH, 2013, MOL PAIN, V9, DOI 10.1186/1744-8069-9-18
   Xu ZH, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.963358
   Yang K, 2022, BIOMED PHARMACOTHER, V148, DOI 10.1016/j.biopha.2022.112717
   Yang W, 2023, FRONT NEUROSCI-SWITZ, V17, DOI 10.3389/fnins.2023.1209262
   Yeung WF, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.5830
   Yin ZH, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/3178154
   Zhang T, 2023, ALTERN THER HEALTH M, V29, P898
   Zhang XW, 2022, PHYTOMEDICINE, V106, DOI 10.1016/j.phymed.2022.154430
   Zhang YQ, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj.o487
   Zhang YW, 2022, FRONT CELL NEUROSCI, V16, DOI 10.3389/fncel.2022.826777
   Zhao WX, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/6886465
NR 77
TC 0
Z9 0
U1 4
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD MAR 14
PY 2025
VL 16
AR 1510331
DI 10.3389/fneur.2025.1510331
PG 19
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 0SX6C
UT WOS:001455251100001
PM 40162011
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Liu, XM
   Lu, J
   Wang, GX
   Chen, X
   Xv, HP
   Huang, J
   Xue, MX
   Tang, JH
AF Liu, Xiaomeng
   Lu, Jing
   Wang, Guoxin
   Chen, Xiu
   Xv, Haiping
   Huang, Jing
   Xue, Mingxin
   Tang, Jinhai
TI Acupuncture for Arthralgia Induced by Aromatase Inhibitors in Patients
   with Breast Cancer: A Systematic Review and Meta-analysis
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE acupuncture; aromatase inhibitor-induced arthralgia; breast cancer;
   meta-analysis
ID ADJUVANT ENDOCRINE THERAPY; CLINICAL-PRACTICE; SHAM ACUPUNCTURE;
   MUSCULOSKELETAL SYMPTOMS; RANDOMIZED-TRIALS; AMERICAN SOCIETY; JOINT
   SYMPTOMS; WOMEN; MANAGEMENT; GUIDELINE
AB Background:
   Aromatase inhibitor-induced arthralgia (AIA) is the most common side effect of aromatase inhibitors (AIs) used in breast cancer patients and is related to the rate of adherence to AIs. The clinical effects of acupuncture on AIA have been assessed by some randomized controlled trials (RCTs). However, some studies reported that acupuncture was effective, while others claimed that it was ineffective. To clarify the clinical and placebo effects of acupuncture in treating AIA, we conducted this meta-analysis.
   Methods:
   Two reviewers (XL and GW) independently searched for RCTs in 5 English databases (PubMed, Web of Science, Embase, Springer, Cochrane Library) and 4 Chinese databases (China National Knowledge Infrastructure Database (CNKI), SinoMed, VIP and Wanfang Database) from their inception to 30 November 2019. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, this meta-analysis was performed by fixed or random-effects models, and data were pooled with mean differences (MDs).
   Results:
   Seven trials involving 603 patients were reviewed. The primary outcome, the Brief Pain Inventory (BPI) score, significantly differed between the acupuncture and control groups [pain-related interference: MD = -1.89, 95% confidence interval (CI) [-2.99, -0.79], Z = 3.36 (P = .008 < .05), pain severity: MD = -1.57, 95% CI [-2.46, -0.68], Z = 3.45 (P = .0006 < .05), worst pain: MD = -2.31, 95% CI [-3.15, -1.48], Z = 5.47 (P < .0001 < .05)]. No severe adverse events were reported in any study.
   Conclusion:
   This meta-analysis showed that acupuncture is a safe and effective treatment for breast cancer patients with AIA. Additional research with improved blinding methods is warranted to further explore the nature of non-specific and placebo effects in true and sham acupuncture.
C1 [Liu, Xiaomeng; Wang, Guoxin; Xue, Mingxin] Nanjing Univ Chinese Med, Nanjing, Peoples R China.
   [Liu, Xiaomeng; Lu, Jing; Chen, Xiu; Xv, Haiping; Xue, Mingxin; Tang, Jinhai] Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China.
   [Huang, Jing] Kunming Med Univ, Affiliated Hosp 3, Kunming, Yunnan, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing Medical University;
   Kunming Medical University
RP Tang, JH (corresponding author), Nanjing Med Univ, Affiliated Hosp 1, Dept Gen Surg, Nanjing 210029, Peoples R China.; Xue, MX (corresponding author), Nanjing Med Univ, Affiliated Hosp 1, Acupuncture Dept, Nanjing 210029, Peoples R China.
EM jhtang@njmu.edu.cn
FU National Key Research and Development Program of China [2016YFC0905900];
   National Natural Science Foundation of China [81872365]; Jiangsu
   Provincial Key Research Development Program [BE2019731]; Jiangsu
   Provincial Key Funding Project for Maternal and Child Health Research
   [F201821]; Clinical Research Project of Jiangsu Province Hospital
   [JSPH-511C-2018-8]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was funded by the National Key Research and Development Program of China
   (No. 2016YFC0905900), National Natural Science Foundation of China (No.
   81872365), Jiangsu Provincial Key Research Development Program (No.
   BE2019731), Jiangsu Provincial Key Funding Project for Maternal and
   Child Health Research (No. F201821) and the Clinical Research Project of
   Jiangsu Province Hospital (No. JSPH-511C-2018-8).
CR Anand K, 2019, CURR ONCOL REP, V21, DOI 10.1007/s11912-019-0795-1
   Armijo-Olivo S, 2017, AM J PHYS MED REHAB, V96, P34, DOI 10.1097/PHM.0000000000000521
   Bae K, 2015, INTEGR CANCER THER, V14, P496, DOI 10.1177/1534735415596573
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Boutron I, 2007, PLOS MED, V4, P370, DOI 10.1371/journal.pmed.0040061
   Burstein HJ, 2014, J CLIN ONCOL, V32, P2255, DOI 10.1200/JCO.2013.54.2258
   Burstein HJ, 2010, J CLIN ONCOL, V28, P3784, DOI 10.1200/JOP.000082
   Chen HY, 2019, AM J CHINESE MED, V47, P1, DOI 10.1142/S0192415X19500010
   Chen L, 2017, BREAST, V33, P132, DOI 10.1016/j.breast.2017.03.015
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Felson DT, 2005, ARTHRITIS RHEUM-US, V52, P2594, DOI 10.1002/art.21364
   Fregni F., 2010, AM J PHYS MED REHABI, V89, p160Y72
   Ghoncheh Mahshid, 2016, Asian Pac J Cancer Prev, V17, P43, DOI 10.7314/apjcp.2016.17.s3.43
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Hadji P, 2014, ANN ONCOL, V25, P372, DOI 10.1093/annonc/mdt513
   Halsey EJ, 2015, ACUPUNCT MED, V33, P188, DOI 10.1136/acupmed-2014-010735
   Harris RE, 2009, NEUROIMAGE, V47, P1077, DOI 10.1016/j.neuroimage.2009.05.083
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   HIGGINS J, 2020, COCHRANE DB SYST REV
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Ingle JN, 2010, J CLIN ONCOL, V28, P4674, DOI 10.1200/JCO.2010.28.5064
   Kawakita K, 2006, J PHARMACOL SCI, V100, P443, DOI 10.1254/jphs.CRJ06004X
   Kothawala P, 2007, MAYO CLIN PROC, V82, P1493, DOI 10.4065/82.12.1493
   Lan Kun-Chan, 2019, Medicines (Basel), V6, DOI [10.3390/medicines6030087, 10.3390/medicines6030087]
   Li J., 2019, China Med Herald, V16, P132
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Moffet HH, 2009, J ALTERN COMPLEM MED, V15, P213, DOI 10.1089/acm.2008.0356
   Moher D, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000097
   Müller ST, 2018, LAB ANIM-UK, V52, P479, DOI 10.1177/0023677218756455
   Murphy CC, 2012, BREAST CANCER RES TR, V134, P459, DOI 10.1007/s10549-012-2114-5
   Nahm N, 2018, ASIA-PAC J CLIN ONCO, V14, P374, DOI 10.1111/ajco.12845
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Papaioannou A, 2007, DRUG AGING, V24, P37, DOI 10.2165/00002512-200724010-00003
   Qin W, 2008, MOL PAIN, V4, DOI 10.1186/1744-8069-4-55
   Roberts K, 2017, CRIT REV ONCOL HEMAT, V111, P66, DOI 10.1016/j.critrevonc.2017.01.010
   Schulz KF, 2010, BMJ-BRIT MED J, V340, DOI [10.1136/bmj.c869, 10.1136/bmj.c332]
   Schulz KF, 2002, LANCET, V359, P696, DOI 10.1016/S0140-6736(02)07816-9
   Tang Y, 2019, BRAIN RES BULL, V151, P144, DOI 10.1016/j.brainresbull.2018.10.015
   The Nordic Cochrane Centre TCC, 2014, COP REV MAN REVMAN
   Vase L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119612
   Vodicka E, 2015, CONTEMP CLIN TRIALS, V43, P1, DOI 10.1016/j.cct.2015.04.004
   Wu MT, 2002, NEUROIMAGE, V16, P1028, DOI 10.1006/nimg.2002.1145
   Ye J., 2015, Shanghai J Acup Moxib, V34, P642
NR 44
TC 15
Z9 20
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD FEB
PY 2021
VL 20
AR 1534735420980811
DI 10.1177/1534735420980811
PG 14
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA QI2AL
UT WOS:000618775300001
PM 33586504
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, DT
   Shi, GX
   Jia, JY
   Tan, FW
   Qi, Y
   Liang, W
   Zhao, ZJ
   Yuan, P
   Gao, Y
   Zhang, GC
   Liu, XH
   Yang, JW
   Wang, LQ
   Wang, X
   Yang, NN
   Tu, JF
   Liu, CZ
AF Zhang, Dan-Tong
   Shi, Guang-Xia
   Jia, Jin-Ying
   Tan, Feng-Wei
   Qi, Yu
   Liang, Wei
   Zhao, Zhi-Jun
   Yuan, Ping
   Gao, Ya
   Zhang, Guo-Chao
   Liu, Xue-Hui
   Yang, Jing-Wen
   Wang, Li-Qiong
   Wang, Xiao
   Yang, Na-Na
   Tu, Jian-Feng
   Liu, Cun-Zhi
TI Electroacupuncture for acute postoperative pain during coughing after
   video-assisted thoracoscopic surgery: study protocol for a pilot
   randomized controlled trial
SO PLOS ONE
LA English
DT Article
ID LUNG-CANCER; THORACOTOMY
AB Background Despite the use of multimodal analgesia regimens following video-assisted thoracoscopic surgery (VATS), acute postoperative pain persists. Electroacupuncture (EA) may alleviate acute postoperative pain following VATS; however, current evidence remains insufficient.Objectives This trial will assess the feasibility and efficacy of EA as an adjunctive treatment compared with sham electroacupuncture (SA) for managing acute postoperative pain during coughing after VATS.Study design and methods In this pilot randomized controlled trial, 60 patients with non-small-cell lung cancer who will undergo VATS will be randomly assigned to either the EA or SA group in a 1:1 ratio. Patients will receive standard care combined with four sessions of EA or SA within 72 h after surgery. The primary outcome will be the average postoperative pain score during coughing, measured using a numeric rating scale within 72 h after surgery. Secondary outcomes will include the average daily pain scores at rest, during coughing, and while mobilizing; incidence of chronic post-surgical pain; quality of life; cough symptom score; and analgesic consumption. All adverse events will be recorded in detail.Discussion This study will determine whether EA as an adjunctive treatment can reduce acute postoperative pain during coughing following VATS.Trial registration ClinicalTrial.gov ITMCTR2024000170 (http://itmctr.ccebtcm.org.cn/zh-CN/Home/ProjectView?pid=f1a344f7-7e06-4665-ad9d-0917d588eba6).
C1 [Zhang, Dan-Tong; Shi, Guang-Xia; Yang, Jing-Wen; Wang, Li-Qiong; Wang, Xiao; Yang, Na-Na; Tu, Jian-Feng; Liu, Cun-Zhi] Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
   [Jia, Jin-Ying; Qi, Yu; Liang, Wei; Zhao, Zhi-Jun; Yuan, Ping; Gao, Ya] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China.
   [Tan, Feng-Wei; Zhang, Guo-Chao] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Thorac Surg,Canc Hosp, Beijing, Peoples R China.
   [Liu, Xue-Hui] Tianjin Univ, Med Coll, Tianjin, Peoples R China.
C3 Beijing University of Chinese Medicine; Zhengzhou University; Chinese
   Academy of Medical Sciences - Peking Union Medical College; Cancer
   Institute & Hospital - CAMS; Peking Union Medical College; Tianjin
   University
RP Yang, NN; Tu, JF (corresponding author), Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
EM 1254614551@qq.com; tujianfeng1@126.com
RI Tu, Jian-Feng/J-7768-2017; Tan, Fengwei/NXC-0547-2025
FU National Administration of Traditional Chinese Medicine
FX We appreciate the contribution of all the researchers and patients
   involved in this study.
CR Bang HJ, 2004, CONTROL CLIN TRIALS, V25, P143, DOI 10.1016/j.cct.2003.10.016
   Bendixen M, 2016, LANCET ONCOL, V17, P836, DOI 10.1016/S1470-2045(16)00173-X
   Cao C, 2013, INTERACT CARDIOV TH, V16, P244, DOI 10.1093/icvts/ivs472
   Chan AW, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.e7586
   Chen SS, 2019, INT J SURG, V69, P132, DOI 10.1016/j.ijsu.2019.05.013
   Chen TY, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/2126416
   Fletcher D, 2015, EUR J ANAESTH, V32, P725, DOI 10.1097/EJA.0000000000000319
   Hawker GA, 2011, ARTHRIT CARE RES, V63, pS240, DOI 10.1002/acr.20543
   Hsu HC, 2022, J NURS SCHOLARSHIP, V54, P411, DOI 10.1111/jnu.12751
   Hutchinson PJ, 2023, NEW ENGL J MED, V388, P2219, DOI 10.1056/NEJMoa2214172
   James KE, 1996, STAT MED, V15, P1421
   Jiang YY, 2023, COMPLEMENT THER MED, V77, DOI 10.1016/j.ctim.2023.102980
   Knezevic NN, 2021, LANCET, V398, P78, DOI 10.1016/S0140-6736(21)00733-9
   Lin RJ, 2022, GEN THORAC CARDIOVAS, V70, P735, DOI 10.1007/s11748-022-01791-w
   Liu JM, 2024, PAIN RES MANAG, V2024, DOI 10.1155/2024/5365456
   Ma X, 2023, ACUPUNCT HERB MED, V3, P139, DOI 10.1097/HM9.0000000000000069
   MacPherson H, 2010, J ALTERN COMPLEM MED, V16, pST1, DOI 10.1089/acm.2010.1610
   Pang LN, 2023, ACUPUNCT HERB MED, V3, P285, DOI 10.1097/HM9.0000000000000087
   Shi W, 2021, J CLIN ANESTH, V75, DOI 10.1016/j.jclinane.2021.110526
   Tu JF, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.25735
   Wang H, 2017, J CLIN NURS, V26, P2744, DOI 10.1111/jocn.13789
   Wong RHL, 2006, ANN THORAC SURG, V81, P2031, DOI 10.1016/j.athoracsur.2005.12.064
   Zhang AL, 2024, ACUPUNCT HERB MED, V4, P346, DOI 10.1097/HM9.0000000000000093
   Zhao L, 2017, JAMA INTERN MED, V177, P508, DOI 10.1001/jamainternmed.2016.9378
   Zhou Mintao, 2017, Zhongguo Zhen Jiu, V37, P705, DOI 10.13703/j.0255-2930.2017.07.006
NR 25
TC 0
Z9 0
U1 2
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 26
PY 2025
VL 20
IS 3
AR e0316698
DI 10.1371/journal.pone.0316698
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0VD0K
UT WOS:001456749600020
PM 40138259
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Burnstock, G
AF Burnstock, Geoffrey
TI Therapeutic potential of purinergic signalling for diseases of the
   urinary tract
SO BJU INTERNATIONAL
LA English
DT Review
DE ATP; co-transmitter; NANC; review; purinergic
ID REFRACTORY PROSTATE-CANCER; P2X(3) RECEPTOR EXPRESSION;
   BOTULINUM-TOXIN-A; GUINEA-PIG; INTERSTITIAL CYSTITIS; EXTRACELLULAR
   NUCLEOTIDES; ADENOSINE-TRIPHOSPHATE; BLADDER DYSFUNCTION;
   CARCINOMA-CELLS; SENSORY NEURONS
AB Purinergic signalling, i.e. ATP acting as an extracellular messenger, has been implicated in control of urinary tract function since 1972. For example, it was shown to be a cotransmitter with acetylcholine in parasympathetic control of bladder contraction and purinoceptors on suburothelial sensory nerves mediating both reflex voiding and pain in response to ATP released from urothelial cells during bladder and ureter distension.
   The most recent studies of purinergic signalling in lower urinary tract pathology includes consideration of the therapeutic potential of purinergic compounds in incontinence, pain, cancer, and in acupuncture, widely used for the treatment of urinary disorders.
   This review begins with background information about the discovery and conceptual steps contributing to our current knowledge of purinergic signalling. It then deals with several topics concerned with the physiology and pathophysiology of the lower urinary tract, including: the involvement in the voiding reflex of ATP released as a co-transmitter with acetylcholine from parasympathetic nerves supplying the bladder and ATP released from urothelial cells during bladder distension to initiate the voiding reflex via P2X(3) receptors on suburothelial low-threshold sensory nerve fibres; this latter mechanosensory transduction pathway is also involved via high-threshold fibres in the initiation of pain. Treatment of prostate and bladder cancer with ATP not only appears to be effective against the primary tumours, but also improves the systemic symptoms associated with advanced malignancy. There is dual control of the tone of blood vessels: constriction by ATP released as a co-transmitter from sympathetic nerves and vasodilatation via ATP released from endothelial cells during shear stress acting on endothelial P2 receptors to release nitric oxide. A purinergic hypothesis is discussed for the mechanism underlying acupuncture, widely used for the treatment of urinary disorders.
C1 Univ Coll Med Sch, Auton Neurosci Ctr, London NW3 2PF, England.
C3 University of London; University College London
RP Burnstock, G (corresponding author), Univ Coll Med Sch, Auton Neurosci Ctr, Rowland Hill St, London NW3 2PF, England.
EM g.burnstock@ucl.ac.uk
RI Burnstock, Geoffrey/AFR-8604-2022
CR Agteresch HJ, 2000, J NATL CANCER I, V92, P321, DOI 10.1093/jnci/92.4.321
   Agteresch HJ, 2000, EUR J CLIN PHARMACOL, V56, P49, DOI 10.1007/s002280050719
   AMBACHE N, 1970, J PHYSIOL-LONDON, V210, P761, DOI 10.1113/jphysiol.1970.sp009240
   Andersson KE, 2002, UROLOGY, V60, P13, DOI 10.1016/S0090-4295(02)01786-7
   Baqi Y, 2009, PURINERG SIGNAL, V5, P91, DOI 10.1007/s11302-008-9103-5
   Birder LA, 2004, AM J PHYSIOL-RENAL, V287, pF1084, DOI 10.1152/ajprenal.00118.2004
   Bo XN, 1999, NEUROREPORT, V10, P1107, DOI 10.1097/00001756-199904060-00037
   Boissier S, 1997, CANCER RES, V57, P3890
   BURNSTOCK G, 1972, BRIT J PHARMACOL, V44, P451, DOI 10.1111/j.1476-5381.1972.tb07283.x
   Burnstock G, 2007, CELL MOL LIFE SCI, V64, P1471, DOI 10.1007/s00018-007-6497-0
   BURNSTOCK G, 1978, BRIT J PHARMACOL, V63, P125, DOI 10.1111/j.1476-5381.1978.tb07782.x
   Burnstock G, 2006, TRENDS PHARMACOL SCI, V27, P166, DOI 10.1016/j.tips.2006.01.005
   BURNSTOCK G, 1976, NEUROSCIENCE, V1, P239, DOI 10.1016/0306-4522(76)90054-3
   Burnstock G, 2010, CELL DEATH DIS, V1, DOI 10.1038/cddis.2009.11
   Burnstock G., 2009, Autonomic & Autacoid Pharmacology, V29, P63, DOI 10.1111/j.1474-8673.2009.00435.x
   Burnstock G, 2002, ARTERIOSCL THROM VAS, V22, P364, DOI 10.1161/hq0302.105360
   Burnstock G, 2009, ACTA PHYSIOL, V195, P415, DOI 10.1111/j.1748-1716.2009.01957.x
   Burnstock G, 2001, HANDB EXP PHARM, V151, P423
   BURNSTOCK G, 1970, BRIT J PHARMACOL, V40, P668, DOI 10.1111/j.1476-5381.1970.tb10646.x
   BURNSTOCK G, 1985, GEN PHARMACOL, V16, P433, DOI 10.1016/0306-3623(85)90001-1
   Burnstock G, 1999, J ANAT, V194, P335, DOI 10.1046/j.1469-7580.1999.19430335.x
   BURNSTOCK G, 1972, PHARMACOL REV, V24, P509
   Burnstock G, 2001, TRENDS PHARMACOL SCI, V22, P182, DOI 10.1016/S0165-6147(00)01643-6
   BURNSTOCK G, 1987, BLOOD VESSELS, V24, P156
   Burnstock G., 2009, ASPECTS PHARM PYELOU, P77
   Burnstock G., 1978, CELL MEMBRAIN RECEPT, P107
   Burnstock G, 2007, PHYSIOL REV, V87, P659, DOI 10.1152/physrev.00043.2006
   Burnstock G, 2009, MOL PAIN, V5, DOI 10.1186/1744-8069-5-69
   Burnstock G, 2009, MED HYPOTHESES, V73, P470, DOI 10.1016/j.mehy.2009.05.031
   Calvert RC, 2008, PURINERG SIGNAL, V4, P377, DOI 10.1007/s11302-008-9123-1
   Chancellor MB, 2008, NAT CLIN PRACT UROL, V5, P319, DOI 10.1038/ncpuro1124
   CHEN CC, 1995, NATURE, V377, P428, DOI 10.1038/377428a0
   Cockayne DA, 2000, NATURE, V407, P1011, DOI 10.1038/35039519
   Donnelly-Roberts DL, 2007, BRIT J PHARMACOL, V151, P571, DOI 10.1038/sj.bjp.0707265
   Engberg S, 2009, J WOUND OSTOMY CONT, V36, P661, DOI 10.1097/WON.0b013e3181bd82dd
   FANG WG, 1992, J CLIN INVEST, V89, P191, DOI 10.1172/JCI115562
   Ford APDW, 2006, BRIT J PHARMACOL, V147, pS132, DOI 10.1038/sj.bjp.0706637
   Gever JR, 2006, PFLUG ARCH EUR J PHY, V452, P513, DOI 10.1007/s00424-006-0070-9
   Gever JR, 2010, BRIT J PHARMACOL, V160, P1387, DOI 10.1111/j.1476-5381.2010.00796.x
   Greig AVH, 2003, J INVEST DERMATOL, V121, P315, DOI 10.1046/j.1523-1747.2003.12379.x
   Harvey RA, 2002, J UROLOGY, V168, P1235, DOI 10.1016/S0022-5347(05)64632-0
   HOYLE CHV, 1989, EUR J PHARMACOL, V174, P115, DOI 10.1016/0014-2999(89)90881-9
   Janssens R, 2001, BRIT J PHARMACOL, V132, P536, DOI 10.1038/sj.bjp.0703833
   JORDAN AM, 1987, CANCER-AM CANCER SOC, V60, P2766, DOI 10.1002/1097-0142(19871201)60:11<2766::AID-CNCR2820601129>3.0.CO;2-0
   KASAKOV L, 1982, EUR J PHARMACOL, V86, P291, DOI 10.1016/0014-2999(82)90330-2
   Knight GE, 2002, AM J PHYSIOL-RENAL, V282, pF281, DOI 10.1152/ajprenal.00293.2000
   Korcok J, 2004, J BONE MINER RES, V19, P642, DOI 10.1359/JBMR.040108
   Langley JN., 1895, J PHYSL, V19, P71
   LEE YH, 1992, J UROLOGY, V147, P16, DOI 10.1016/S0022-5347(17)37121-5
   LEWIS C, 1995, NATURE, V377, P432, DOI 10.1038/377432a0
   MACKENZIE I, 1982, NEUROSCIENCE, V7, P997, DOI 10.1016/0306-4522(82)90056-2
   Mönkkönen H, 2008, ANTI-CANCER DRUG, V19, P391, DOI 10.1097/CAD.0b013e3282f632bf
   Moore KH, 2001, J NEUROSCI, V21, DOI 10.1523/JNEUROSCI.21-18-j0002.2001
   Nishiguchi J, 2004, EUR J NEUROSCI, V20, P474, DOI 10.1111/j.1460-9568.2004.03508.x
   O'Neill M, 2006, PSYCHOPHARMACOLOGY, V184, P46, DOI 10.1007/s00213-005-0240-z
   O'Reilly BA, 2002, J UROLOGY, V167, P157, DOI 10.1016/S0022-5347(05)65403-1
   O'Reilly BA, 2001, J UROLOGY, V165, P1730, DOI 10.1016/S0022-5347(05)66403-8
   PALEA S, 1993, J UROLOGY, V150, P2007, DOI 10.1016/S0022-5347(17)35955-4
   Pawinski A, 1996, J UROLOGY, V156, P1934, DOI 10.1016/S0022-5347(01)65396-5
   Ralevic V, 1998, PHARMACOL REV, V50, P413
   RAPAPORT E, 1983, J CELL PHYSIOL, V114, P279, DOI 10.1002/jcp.1041140305
   Rocha I, 2001, AUTON NEUROSCI-BASIC, V88, P6, DOI 10.1016/S1566-0702(00)00284-8
   Rong WF, 2000, J PHYSIOL-LONDON, V524, P891, DOI 10.1111/j.1469-7793.2000.00891.x
   Rong WF, 2004, NEUROPHARMACOLOGY, V47, P1093, DOI 10.1016/j.neuropharm.2004.08.003
   Ryten M, 2002, J CELL BIOL, V158, P345, DOI 10.1083/jcb.200202025
   Shabbir M, 2008, BJU INT, V102, P108, DOI 10.1111/j.1464-410X.2008.07578.x
   Shabbir M, 2008, BJU INT, V101, P352, DOI 10.1111/j.1464-410X.2007.07293.x
   Shabbir M, 2008, BJU INT, V101, P106, DOI 10.1111/j.1464-410X.2007.07286.x
   Shabbir M, 2009, INT J UROL, V16, P143, DOI 10.1111/j.1442-2042.2008.02207.x
   Smith CP, 2005, NEUROCHEM INT, V47, P291, DOI 10.1016/j.neuint.2005.04.021
   Smith DJ., 1994, NEUROUROL URODYNAM, V13, P414
   Soe SHTE, 2009, MULT SCLER J, V15, P1376, DOI 10.1177/1352458509107020
   Sun Y, 2001, Urology, V57, P131, DOI 10.1016/S0090-4295(01)01106-2
   Sun Y, 2004, J UROLOGY, V171, P448, DOI 10.1097/01.ju.0000099660.46774.3c
   Tempest HV, 2004, BJU INT, V93, P1344, DOI 10.1111/j.1464-410X.2004.04858.x
   Tong YQ, 2009, J ALTERN COMPLEM MED, V15, P905, DOI 10.1089/acm.2009.0062
   van der Weyden L, 2000, HYPERTENSION, V36, P1093, DOI 10.1161/01.HYP.36.6.1093
   Vlaskovska M, 2001, J NEUROSCI, V21, P5670, DOI 10.1523/JNEUROSCI.21-15-05670.2001
   White N, 2006, TRENDS PHARMACOL SCI, V27, P211, DOI 10.1016/j.tips.2006.02.004
   Yuping Wang, 2006, J Tradit Chin Med, V26, P106
   Zimmermann H, 2001, DRUG DEVELOP RES, V52, P44, DOI 10.1002/ddr.1097
NR 81
TC 53
Z9 62
U1 0
U2 20
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1464-4096
J9 BJU INT
JI BJU Int.
PD JAN
PY 2011
VL 107
IS 2
BP 192
EP 204
DI 10.1111/j.1464-410X.2010.09926.x
PG 13
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 702UU
UT WOS:000285922200003
PM 21208364
DA 2026-01-16
ER

PT J
AU Bossi, P
   Ghiani, M
   Argenone, A
   Depenni, R
AF Bossi, Paolo
   Ghiani, Massimo
   Argenone, Angela
   Depenni, Roberta
TI Is pain part of a systemic syndrome in head and neck cancer?
SO SUPPORTIVE CARE IN CANCER
LA English
DT Review
DE Head and neck cancer; Pain; Pain management; Multidisciplinary approach;
   Opioids
ID QUALITY-OF-LIFE; PLACEBO-CONTROLLED TRIAL; PECTIN NASAL SPRAY; ORAL
   MUCOSITIS; DOUBLE-BLIND; DEPRESSION; FENTANYL; ASSOCIATION; MANAGEMENT;
   FATIGUE
AB Head and neck cancers (HNC) represent 5% of all malignancies worldwide with about 180,000 cancer deaths per year. Patients with HNC are characterized by a systemic inflammatory state, generally associated with worse outcomes. Treatment-related toxicity is common among HNC patients and causes systemic consequences such as fatigue or cognitive dysfunction. The therapeutic treatments of HNC involve the release in circulation of inflammatory systemic mediators, whose effects trigger a vicious circle that may lead to functional and behavioral alterations. The areas of the head and neck are highly sensitive to pain. Literature data confirm that in HNC patients, pain is one of the most distressing symptoms across all the phases of treatment. Pain is associated with worse general conditions, depression, fatigue, impaired cognitive functions, and lower survival rate. The treatment of advanced HNC cases is multimodal and requires a multidisciplinary psycho-socio-pharmacological approach mediated by a team of experts. The pharmacological approach in management of HNC patients with pain is fundamental and involves the use of opioids, NSAIDs, steroids, or other drugs. Opioids in pain management therapy in patients with HNC could allow the pain level to be adequately monitored, thus improving quality of life. The integration of opioid and non-opioid therapy as well as non-pharmacological interventions is essential for the rehabilitation of physical, social, and psychological functions and to achieve pain control in patients with HNC. Opioid treatment is the mainstay for pain control, being used both for background and breakthrough cancer pain (BTcP) episodes. Fentanyl, easily absorbed and generally well tolerated, appears to be a possible choice due to its versatility. Non-pharmacological interventions, such as tailored yoga, physical exercise, and acupuncture, may have a role in pain management in patients with HNC.
C1 [Bossi, Paolo] ASST Spedali Civili Brescia, Med Oncol, Brescia, Italy.
   [Bossi, Paolo] Univ Brescia, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, Brescia, Italy.
   [Ghiani, Massimo] A Businco Hosp, Oncol Dept, Cagliari, Italy.
   [Argenone, Angela] Ist Nazl Tumori IRCCS G Pascale Fdn, Radiat Oncol Dept, Naples, Italy.
   [Depenni, Roberta] Univ Hosp Modena & Reggio Emilia, Oncol & Haematol Dept, Modena, Italy.
C3 Hospital Spedali Civili Brescia; University of Brescia; Universita di
   Modena e Reggio Emilia; Universita di Modena e Reggio Emilia Hospital
RP Bossi, P (corresponding author), ASST Spedali Civili Brescia, Med Oncol, Brescia, Italy.; Bossi, P (corresponding author), Univ Brescia, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, Brescia, Italy.
EM paolo.bossi@unibs.it
RI ; Bossi, Paolo/IAR-1470-2023
OI Ghiani, Massimo/0009-0003-5968-8030; Bossi, Paolo/0000-0003-0135-0224
CR Adair M, 2018, INTEGR CANCER THER, V17, P774, DOI 10.1177/1534735417753540
   Al-Dasooqi N, 2009, CANCER CHEMOTH PHARM, V64, P1, DOI 10.1007/s00280-009-0984-y
   Allison RR, 2014, CANCER-AM CANCER SOC, V120, P1433, DOI 10.1002/cncr.28553
   Apkarian AV, 2004, J NEUROSCI, V24, P10410, DOI 10.1523/JNEUROSCI.2541-04.2004
   Bandieri E, 2016, J CLIN ONCOL, V34, P436, DOI 10.1200/JCO.2015.61.0733
   Barcellos-Hoff MH, 1998, RADIAT RES, V150, pS109, DOI 10.2307/3579813
   Bell BC, 2013, J PAIN RES, V6, P843, DOI 10.2147/JPR.S54788
   Bossi P, 2014, ORAL ONCOL, V50, P884, DOI 10.1016/j.oraloncology.2014.06.013
   Capuron L, 2003, BRAIN BEHAV IMMUN, V17, pS119
   CAVAILLON JM, 1992, CIRC SHOCK
   Chang Andrew, 2015, J Pain Palliat Care Pharmacother, V29, P247, DOI [10.3109/15360288.2015.1063560, 10.3109/15360288.2015.1063560]
   Chapman CR, 1999, LANCET, V353, P2233, DOI 10.1016/S0140-6736(99)01308-2
   Chua KSG, 1999, J PAIN SYMPTOM MANAG, V18, P193, DOI 10.1016/S0885-3924(99)00070-6
   Ciofi P, 2009, ENDOCRINOLOGY, V150, P5509, DOI 10.1210/en.2009-0584
   Clarkson Jan E, 2010, Cochrane Database Syst Rev, pCD001973, DOI 10.1002/14651858.CD001973.pub4
   Cleeland CS, 2003, CANCER-AM CANCER SOC, V97, P2919, DOI 10.1002/cncr.11382
   Cohen E, 2008, CANCER NURS, V31, pE1, DOI 10.1097/01.NCC.0000305693.67131.7d
   Criswell T, 2003, ONCOGENE, V22, P5813, DOI 10.1038/sj.onc.1206680
   Dantzer R, 2004, EUR J PHARMACOL, V500, P399, DOI 10.1016/j.ejphar.2004.07.040
   Davis RJ, 2000, CELL, V103, P239, DOI 10.1016/S0092-8674(00)00116-1
   Denham JW, 2002, RADIOTHER ONCOL, V63, P129, DOI 10.1016/S0167-8140(02)00060-9
   Du MY, 2012, PROG NEURO-PSYCHOPH, V36, P11, DOI 10.1016/j.pnpbp.2011.09.014
   DUFTON BD, 1989, INT J PSYCHIAT MED, V19, P291, DOI 10.2190/JDJK-0795-5BFL-5N6K
   Elad S, 2020, CANCER-AM CANCER SOC, V126, P4423, DOI [10.1002/cncr.28592, 10.1002/cncr.33100]
   Enting RH, 2007, J PAIN SYMPTOM MANAG, V34, P523, DOI 10.1016/j.jpainsymman.2007.01.007
   Epstein JB, 2001, ORAL ONCOL, V37, P632, DOI 10.1016/S1368-8375(01)00005-7
   Giusti R, 2018, BRIT J PAIN, V12, P155, DOI 10.1177/2049463717736787
   Green CR, 2011, CANCER-AM CANCER SOC, V117, P1994, DOI 10.1002/cncr.25761
   Grond S, 1997, PAIN, V69, P191, DOI 10.1016/S0304-3959(96)03254-X
   Gustin SM, 2013, J PAIN, V14, P1642, DOI 10.1016/j.jpain.2013.08.005
   Haddad R, 2009, CANCER, V115, P4514, DOI 10.1002/cncr.24525
   Hart Robert P, 2003, Curr Pain Headache Rep, V7, P116, DOI 10.1007/s11916-003-0021-5
   HESS R, 1972, EUR J CLIN PHARMACOL, V4, P137, DOI 10.1007/BF00561135
   Howren MB, 2013, J CONSULT CLIN PSYCH, V81, P299, DOI 10.1037/a0029940
   Illi J, 2012, CYTOKINE, V58, P437, DOI 10.1016/j.cyto.2012.02.015
   Jain MK, 2005, NAT REV DRUG DISCOV, V4, P977, DOI 10.1038/nrd1901
   Jemal Ahmedin Bray Freddie Center Melissa M, 2011, CA-CANCER J CLIN, V61, P90
   Jiang JR, 2019, J CLIN ONCOL, V37, P135, DOI 10.1200/JCO.18.00896
   Johansen-Berg H, 2008, CEREB CORTEX, V18, P1374, DOI 10.1093/cercor/bhm167
   Kestenbaum MG, 2014, PAIN MED, V15, P1129, DOI 10.1111/pme.12464
   Kim ES, 2015, KOREAN J PAIN, V28, P73, DOI 10.3344/kjp.2015.28.2.73
   Krysko DV, 2011, TRENDS IMMUNOL, V32, P157, DOI 10.1016/j.it.2011.01.005
   Kvillemo P, 2011, CANCER NURS, V34, P24, DOI 10.1097/NCC.0b013e3181e2d0df
   Laird BJA, 2016, J CLIN ONCOL, V34, P2769, DOI 10.1200/JCO.2015.65.7742
   Lalla RV, 2014, ORAL ONCOL, V50, P1098, DOI 10.1016/j.oraloncology.2014.08.001
   Li Y, 2008, J NEUROSCI, V28, P2814, DOI 10.1523/JNEUROSCI.5447-07.2008
   Logan RM, 2007, ORAL ONCOL, V43, P395, DOI 10.1016/j.oraloncology.2006.04.011
   Lopez G, 2018, J CANCER, V9, P3613, DOI 10.7150/jca.26527
   May A, 2008, PAIN, V137, P7, DOI 10.1016/j.pain.2008.02.034
   Mehanna HM, 2006, ARCH OTOLARYNGOL, V132, P27, DOI 10.1001/archotol.132.1.27
   Mejias NH, 2018, J INFLAMM-LOND, V15, DOI 10.1186/s12950-018-0198-3
   Mirabile A, 2016, CRIT REV ONCOL HEMAT, V99, P100, DOI 10.1016/j.critrevonc.2015.11.010
   MOLE RH, 1953, BRIT J RADIOL, V26, P234, DOI 10.1259/0007-1285-26-305-234
   Moore R Andrew, 2009, Cochrane Database Syst Rev, pCD007076, DOI 10.1002/14651858.CD007076.pub2
   MUSTIAN KM, 2013, EUR MED J ONCOL
   Paice JA, 2014, J CLIN ONCOL, V32, P1721, DOI 10.1200/JCO.2013.52.5196
   Pendergrass J C., 2018, Innov Clin Neurosci
   Pinquart M, 2010, PSYCHOL MED, V40, P1797, DOI 10.1017/S0033291709992285
   Rainville P, 1997, SCIENCE, V277, P968, DOI 10.1126/science.277.5328.968
   Rodriguez-Raecke R, 2009, J NEUROSCI, V29, P13746, DOI 10.1523/JNEUROSCI.3687-09.2009
   Rogers LQ, 2008, HEAD NECK-J SCI SPEC, V30, P1310, DOI 10.1002/hed.20873
   Rogers LQ, 2009, HEAD NECK-J SCI SPEC, V31, P994, DOI 10.1002/hed.21053
   ROSOW CE, 1987, DRUG ALCOHOL DEPEN, V20, P329, DOI 10.1016/0376-8716(87)90006-8
   Roxburgh CSD, 2014, BRIT J CANCER, V110, P1409, DOI 10.1038/bjc.2014.90
   Russi EG, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/518261
   Sarvizadeh Mostafa, 2015, Adv Biomed Res, V4, P44, DOI [10.4103/2277-9175.151254, 10.4103/2277-9175.151254]
   Scharpf J, 2009, ARCH OTOLARYNGOL, V135, P789, DOI 10.1001/archoto.2009.107
   Schubert C, 2007, BRAIN BEHAV IMMUN, V21, P413, DOI 10.1016/j.bbi.2006.11.004
   Schug SA, 2017, DRUGS, V77, P747, DOI 10.1007/s40265-017-0727-z
   Sheline YI, 1999, J NEUROSCI, V19, P5034
   Shinn EH, 2016, PSYCHOSOM MED, V78, P38, DOI 10.1097/PSY.0000000000000256
   Srikrishna G, 2009, NEOPLASIA, V11, P615, DOI 10.1593/neo.09284
   Takase H, 2011, AURIS NASUS LARYNX, V38, P495, DOI 10.1016/j.anl.2010.12.012
   van Nieuwenhuizen AJ, 2018, SUPPORT CARE CANCER, V26, P1087, DOI 10.1007/s00520-017-3926-y
   Weber RJ, 2009, BRAIN BEHAV IMMUN, V23, P993, DOI 10.1016/j.bbi.2009.05.057
   Woolf CJ, 2000, SCIENCE, V288, P1765, DOI 10.1126/science.288.5472.1765
   Xiao CH, 2013, ORAL ONCOL, V49, P360, DOI 10.1016/j.oraloncology.2012.10.004
   Yang CA, 2015, J AUTOIMMUN, V61, P1, DOI 10.1016/j.jaut.2015.05.001
   Yennurajalingam S, 2013, J CLIN ONCOL, V31, P3076, DOI 10.1200/JCO.2012.44.4661
   Younger JW, 2011, PAIN, V152, P1803, DOI 10.1016/j.pain.2011.03.028
   Zeppetella G, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004311.pub4
NR 81
TC 16
Z9 18
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD FEB
PY 2020
VL 28
IS 2
BP 451
EP 459
DI 10.1007/s00520-019-05147-8
EA NOV 2019
PG 9
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA KW3FF
UT WOS:000495951700001
PM 31713692
DA 2026-01-16
ER

PT J
AU Molassiotis, A
   Suen, LKP
   Cheng, HL
   Mok, TSK
   Lee, SCY
   Wang, CH
   Lee, P
   Leung, H
   Chan, V
   Lau, TKH
   Yeo, W
AF Molassiotis, Alexander
   Suen, Lorna K. P.
   Cheng, Hui Lin
   Mok, T. S. K.
   Lee, Sara C. Y.
   Wang, C. H.
   Lee, Paul
   Leung, Howan
   Chan, V.
   Lau, T. K. H.
   Yeo, Winnie
TI A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the
   Effectiveness of Acupuncture in the Management of Chemotherapy-Induced
   Peripheral Neuropathy
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; chemotherapy-induced peripheral neuropathy; cancer;
   neurotoxicity; quality of life; pain
ID CANCER; PAIN; PREVENTION; COMMON
AB Purpose: Chemotherapy-induced peripheral neuropathy is a complex side effect with few available treatment options. The aim of the study was to test the effectiveness of an 8-week course of acupuncture in the management of chemotherapy-induced peripheral neuropathy in cancer patients who were receiving or had received neurotoxic chemotherapy. Methods: Randomized assessor-blinded controlled trial with 2 arms; one arm received acupuncture twice weekly for 8 weeks, while the other arm was a wait-list control group receiving only standard care. Primary outcome was pain intensity and interference over the past week using the Brief Pain Inventory at the end of the intervention. Secondary outcomes included clinical assessment (CTCAE [Common Toxicity Criteria for Adverse Events] grading and Total Neuropathy Score-Clinical Version) and nerve conduction studies; and patient-reported outcome measures (Functional Assessment of Cancer Therapy-Gynecologic Oncology Group-Neurotoxicity Quality of Life scale and Symptom Distress Scale) assessed at baseline, end of treatment (8 weeks), week 14, and week 20 from the beginning of treatment. Results: Eighty-seven patients were randomized to the experimental arm (n = 44) and to the standard care wait-list control arm (n = 43). Significant changes at 8 weeks were detected in relation to primary outcome (pain), the clinical neurological assessment, quality of life domains, and symptom distress (all P < .05). Improvements in pain interference, neurotoxicity-related symptoms, and functional aspects of quality of life were sustained in the 14-week assessment (P < .05), as were physical and functional well-being at the 20-week assessment (P < .05). Conclusions: Acupuncture is an effective intervention for treating chemotherapy-induced peripheral neuropathy and improving patients' quality of life and experience with neurotoxicity-related symptoms with longer term effects evident.
C1 [Molassiotis, Alexander; Suen, Lorna K. P.; Cheng, Hui Lin; Lee, Sara C. Y.; Lee, Paul] Hong Kong Polytech Univ, Kowloon, Hong Kong, Peoples R China.
   [Mok, T. S. K.; Wang, C. H.; Leung, Howan; Chan, V.; Lau, T. K. H.; Yeo, Winnie] Prince Wales Hosp, Sha Tin, Hong Kong, Peoples R China.
C3 Hong Kong Polytechnic University; Prince of Wales Hospital Hong Kong
RP Molassiotis, A (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hung Hom, 11 Yuk Choi Rd, Hong Kong, Peoples R China.
EM alex.molasiotis@polyu.edu.hk
RI Suen, Lorna/F-5077-2014; Mok, Tony/B-2310-2019; Yeo, Winnie/R-4792-2018;
   Molassiotis, Alex/MDS-6695-2025
OI Mok, Tony/0000-0002-8251-0551; Yeo, Winnie/0000-0002-0863-8469; Cheng,
   Huilin/0000-0002-6117-3832; Molassiotis, Alex/0000-0001-6351-9991
FU Hong Kong's Health & Medical Research Fund [12131801]
FX The author(s) received the following financial support for the research,
   authorship, and/or publication of this article: This trial was funded by
   the Hong Kong's Health & Medical Research Fund (Reference Number
   12131801).
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Armstrong T, 2005, ONCOL NURS FORUM, V32, P305, DOI 10.1188/05.ONF.305-311
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Cavaletti G, 2010, EUR J CANCER, V46, P479, DOI 10.1016/j.ejca.2009.12.008
   CLEELAND CS, 1994, NEW ENGL J MED, V330, P592, DOI 10.1056/NEJM199403033300902
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Franconi G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/516916
   Frigeni B, 2011, J PERIPHER NERV SYST, V16, P228, DOI 10.1111/j.1529-8027.2011.00351.x
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Hoitsma E, 2004, J NEUROL SCI, V227, P119, DOI 10.1016/j.jns.2004.08.012
   Huang HQ, 2007, INT J GYNECOL CANCER, V17, P387, DOI 10.1111/j.1525-1438.2007.00794.x
   Kerckhove N, 2017, PAIN, V158, P180, DOI 10.1097/j.pain.0000000000000743
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Mason S, 2002, BRIT MED J, V325, P832, DOI 10.1136/bmj.325.7368.832
   McCorkle R., 1998, USERS MANUAL SYMPTOM
   Molassiotis A, 2013, ANN ONCOL, V24, P1645, DOI 10.1093/annonc/mdt034
   Molassiotis A, 2013, J CLIN ONCOL, V31, P2058, DOI 10.1200/JCO.2013.49.2470
   Ocean AJ, 2004, SUPPORT CARE CANCER, V12, P619, DOI 10.1007/s00520-004-0657-7
   Ozols RF, 2003, J CLIN ONCOL, V21, P3194, DOI 10.1200/JCO.2003.02.153
   Paterson C, 2005, BMJ-BRIT MED J, V330, P1202, DOI 10.1136/bmj.330.7501.1202
   Pike Crystal T, 2012, Chemother Res Pract, V2012, P913848, DOI 10.1155/2012/913848
   Postma TJ, 2000, ANN ONCOL, V11, P509, DOI 10.1023/A:1008345613594
   Raman S, 2018, QUAL LIFE RES, V27, P1089, DOI 10.1007/s11136-017-1745-8
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Shimozuma K, 2012, SUPPORT CARE CANCER, V20, P3355, DOI 10.1007/s00520-012-1492-x
   Wong K, 2013, SUPPORT CARE CANCER, V21, P1893, DOI 10.1007/s00520-013-1731-9
   Wong Raimond, 2006, Acupunct Med, V24, P87
   Wong R, 2016, INTEGR CANCER THER, V15, P153, DOI 10.1177/1534735415627926
   Xinnong C., 1999, Chinese acupuncture and moxibustion
   Yost KJ, 2005, EVAL HEALTH PROF, V28, P172, DOI 10.1177/0163278705275340
NR 32
TC 70
Z9 81
U1 6
U2 38
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD MAR 25
PY 2019
VL 18
AR 1534735419836501
DI 10.1177/1534735419836501
PG 12
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Integrative & Complementary Medicine
GA HQ3HE
UT WOS:000462300700001
PM 30905173
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Kwon, K
   Kerin-Ayres, K
   Lacey, JJL
   Grant, S
AF Kwon, K.
   Kerin-Ayres, Kim
   Lacey, Judith J. L.
   Grant, Suzanne
TI Acupuncture for treating a symptom cluster (pain, fatigue, sleep,
   neuropathy) for women with breast cancer: A feasibility study
SO ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
C1 [Kwon, K.; Lacey, Judith J. L.; Grant, Suzanne] Western Sydney Univ, Natl Inst Complementary Med, Westmead, NSW, Australia.
   [Kerin-Ayres, Kim; Lacey, Judith J. L.; Grant, Suzanne] Chris Obrien Lifehouse, Support Care, Camperdown, NSW, Australia.
   [Lacey, Judith J. L.] Univ Sydney, Med Sch, Sydney, NSW, Australia.
C3 Western Sydney University; Chris O'Brien Lifehouse; University of Sydney
RI Grant, Suzanne/JTT-6993-2023; Lacey, Judith/AAI-5754-2021
CR Cheng KKF, 2014, EUR J ONCOL NURS, V18, P3, DOI 10.1016/j.ejon.2013.10.005
NR 1
TC 0
Z9 0
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1743-7555
EI 1743-7563
J9 ASIA-PAC J CLIN ONCO
JI Asia-Pac. J. Clin. Oncol.
PD NOV
PY 2022
VL 18
SU 3
SI SI
MA 405
BP 213
EP 214
PG 2
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 5N7GN
UT WOS:000871956500361
DA 2026-01-16
ER

PT J
AU Eriksen, WT
   Singerman, L
   Romero, SAD
   Bussell, J
   Barg, FK
   Mao, JJ
AF Eriksen, Whitney T.
   Singerman, Lydia
   Romero, Sally A. D.
   Bussell, Jason
   Barg, Frances K.
   Mao, Jun J.
TI Understanding the Use of Acupuncture for Insomnia Among Cancer
   Survivors: A Qualitative Study
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE acupuncture; insomnia; knowledge; belief; cancer; qualitative research
ID COGNITIVE-BEHAVIORAL THERAPY; ALTERNATIVE MEDICINE; COMPLEMENTARY;
   OPTIONS; TRIAL; PREVALENCE; FATIGUE; PAIN
AB Objective: To understand cancer survivors' perceptions regarding the use of acupuncture for the treatment of cancer-related insomnia. Design: Semistructured interviews with cancer survivors participating in a randomized controlled trial comparing the effectiveness of Cognitive Behavioral Therapy for Insomnia (CBT-I) and acupuncture for the treatment of insomnia. Interviews were conducted before randomization into either treatment option, and structured to elicit participants' experiences with insomnia as well as their beliefs and understanding surrounding acupuncture for the treatment of insomnia. An integrated approach was used for data analysis. Subjects: Sixty-three cancer survivors with DSM-V diagnosed insomnia. Results: Participants shared a broad lack of understanding regarding acupuncture for the treatment of insomnia. Specifically, individuals in this study expressed confusion surrounding what symptoms or medical conditions acupuncture could be used to treat, how acupuncture works, and how long the effects of acupuncture last. Conclusions: This study identified three specific gaps in knowledge, including treatment target, mechanism, and durability, surrounding the use of acupuncture for insomnia in cancer survivors. Addressing these gaps by providing appropriate and timely education surrounding the use of acupuncture to treat insomnia is essential to increase the evidence-informed utilization of acupuncture and to better meet patients' needs among cancer survivors.
C1 [Eriksen, Whitney T.; Barg, Frances K.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Singerman, Lydia] Rutgers New Jersey Med Sch, Newark, NJ USA.
   [Romero, Sally A. D.; Bussell, Jason; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
C3 University of Pennsylvania; Rutgers University System; Rutgers
   University New Brunswick; Rutgers University Biomedical & Health
   Sciences; Memorial Sloan Kettering Cancer Center
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, 1429 First Ave, New York, NY 10021 USA.
EM maoj@mskcc.org
RI Barg, Frances/E-1703-2017
OI Barg, Frances/0000-0003-3328-1980
FU Patient-Centered Outcomes Research Institute (PCORI) award
   [CER-1403-14292]; National Cancer Institute of the National Institutes
   of Health [2P30CA016520-40]; Memorial Sloan Kettering Cancer Center
   [3P30CA008748-50, R25CA020449]; National Cancer Institute [R25CA020449,
   P30CA008748, P30CA016520] Funding Source: NIH RePORTER
FX The authors would like to thank the patients, oncologists, nurses, and
   clinical staff at all study sites for their contributions to this study.
   The authors would also like to thank Christina Seluzicki for her
   editorial contributions. Research related to the development of this
   article was supported in part by a Patient-Centered Outcomes Research
   Institute (PCORI) award (CER-1403-14292) and by National Cancer
   Institute of the National Institutes of Health grants to the University
   of Pennsylvania Abramson Cancer Center (2P30CA016520-40) and the
   Memorial Sloan Kettering Cancer Center (3P30CA008748-50; R25CA020449).
   The content is solely the responsibility of the authors and does not
   necessarily represent official views of PCORI, its Board of Governors or
   Methodology Committee, or the National Institutes of Health.
CR Asnis GM, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010050
   Bao T, 2018, INTEGR CANC THER
   Boon H, 2000, J CLIN ONCOL, V18, P2515, DOI 10.1200/JCO.2000.18.13.2515
   Bradley EH, 2007, HEALTH SERV RES, V42, P1758, DOI 10.1111/j.1475-6773.2006.00684.x
   Chan Kara, 2016, Health Mark Q, V33, P78, DOI [10.1080/07359683.2016.1132051, 10.1080/07359683.2016.1132051]
   Chapman AL, 2015, J ROY COLL PHYS EDIN, V45, P201, DOI 10.4997/JRCPE.2015.305
   Charmaz Kathy., 2000, HDB QUALITATIVE RES, P509
   Curry LA, 2009, CIRCULATION, V119, P1442, DOI 10.1161/CIRCULATIONAHA.107.742775
   Garland SN, 2018, SUPPORT CARE CANCER, V26, P2407, DOI 10.1007/s00520-018-4086-4
   Garland SN, 2016, CONTEMP CLIN TRIALS, V47, P349, DOI 10.1016/j.cct.2016.02.010
   Garland SN, 2014, J CLIN ONCOL, V32, P449, DOI 10.1200/JCO.2012.47.7265
   Haddad NE, 2014, INTEGR CANCER THER, V13, P371, DOI 10.1177/1534735413520181
   Hedges Christine, 2012, Nurse Pract, V37, P14, DOI 10.1097/01.NPR.0000408276.28016.fb
   Huang W, 2011, J CLIN SLEEP MED, V7, P95
   Johns C, 2016, BREAST CANCER RES TR, V156, P415, DOI 10.1007/s10549-016-3765-4
   MacPherson H, 2017, PAIN, V158, P784, DOI 10.1097/j.pain.0000000000000747
   Mao JJ, 2010, PRIMARY CARE, V37, P105, DOI 10.1016/j.pop.2009.09.010
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P228, DOI 10.1016/j.ctim.2006.09.009
   Morgenthaler T, 2006, SLEEP, V29, P1415
   Palesh OG, 2010, J CLIN ONCOL, V28, P292, DOI 10.1200/JCO.2009.22.5011
   Patil S, 2016, CURR PAIN HEADACHE R, V20, DOI 10.1007/s11916-016-0552-1
   Rosini Jamie M, 2015, Nursing, V45, P38, DOI [10.1097/01.nurse.0000460712.06302.19, 10.1097/01.NURSE.0000460712.06302.19]
   Savard J, 2011, J CLIN ONCOL, V29, P3580, DOI 10.1200/JCO.2010.33.2247
   Sharma N, 2012, PSYCHO-ONCOLOGY, V21, P1003, DOI 10.1002/pon.2004
   Stepanski EJ, 2009, J CLIN SLEEP MED, V5, P132
   Tasaki K, 2002, PSYCHO-ONCOL, V11, P212, DOI 10.1002/pon.552
   Trudel-Fitzgerald C, 2014, HEALTH PSYCHOL, V33, P1012, DOI 10.1037/a0033497
   Vincent C, 1996, BRIT J CLIN PSYCHOL, V35, P37, DOI 10.1111/j.2044-8260.1996.tb01160.x
   White Adrian, 2004, Acupunct Med, V22, P122
   Zhang Y, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/710750
   Zhao KC, 2013, INT REV NEUROBIOL, V111, P217, DOI 10.1016/B978-0-12-411545-3.00011-0
NR 32
TC 14
Z9 16
U1 0
U2 63
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD SEP
PY 2018
VL 24
IS 9-10
BP 962
EP 967
DI 10.1089/acm.2018.0156
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GU6VP
UT WOS:000445455600014
PM 30247951
DA 2026-01-16
ER

PT J
AU Shi, KJ
   Tang, Y
   He, FY
   Xiao, X
   Zhang, JY
   Jin, YX
   Wang, YX
   Zhang, Q
AF Shi, Kejin
   Tang, Ying
   He, Fengyi
   Xiao, Xiao
   Zhang, Jiayuan
   Jin, Yuxia
   Wang, Yunxia
   Zhang, Qi
TI The maintenance effect of acupuncture on the side effects of breast
   cancer endocrine therapy A protocol for systematic review and meta
   analysis
SO MEDICINE
LA English
DT Review
DE acupuncture; breast cancer; side effects; systematic review protocol
ID WOMEN; MENOPAUSE; ADHERENCE; SYMPTOMS
AB Background: Breast cancer is common among women throughout the world and endocrine therapy is an established part of its treatment. But, unfortunately, this has also resulted in intolerable side effects affecting the quality of life. Acupuncture has been widely used to treat endocrine-related side effects in patients with breast cancer, but how long its effect can be maintained has not been published. The systematic review is designed to evaluate the maintenance efficacy of acupuncture for related side effects after breast cancer endocrine therapy.
   Methods and analysis: We will search for the following databases: PubMed, Embase, Cochrane Library, Web of Science, including China National Knowledge Infrastructure (CNKI), WanFang Data, Technology Periodical Database (VIP), and China Biology Medicine (CBM) from inception to May 2020. Two reviewers will search these databases, collect all articles, and assess the quality of studies separately, and there will be no limitations on language. The primary outcomes will be assessed using acupuncture for endocrine-related hot flashes and joint pain duration (1 month, 3 months, 6 months). Measurement tools include the Kupperman index, Brief Pain Inventory Short Form (BPI-SF), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Brief Pain Inventory-Short (BPI-SF). We will use RevMan V.5.3 for meta-analysis and employ the Grading of Recommendations Assessment, Development and Evaluation System to assess the quality of evidence.
   Results: This systematic review will evaluate the maintenance efficacy of acupuncture on the side effects of breast cancer endocrine therapy.
   Conclusion: This study will provide high-quality current evidence of how long its effect can be maintained after acupuncture for related side effects after breast cancer endocrine therapy.
   Ethics and dissemination: Ethical committee approval is not required for this systematic review as patient data will not be collected. This study will help to inform doctors and researchers on the duration of acupuncture treatment for endocrine-related hot flashes and joint pain. The results will be published in a peer-reviewed journal and will be disseminated in relevant conferences.
C1 [Shi, Kejin; Tang, Ying; He, Fengyi; Xiao, Xiao; Zhang, Jiayuan; Jin, Yuxia; Wang, Yunxia; Zhang, Qi] Chengdu Univ Tradit Chinese Med, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Zhang, Q (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Basic Med, Chengdu 610000, Sichuan, Peoples R China.
EM zhangqicduntcm@163.com
FU National Natural Science Foundation of China [81873222]
FX This paper is funded by National Natural Science Foundation of China
   (No. 81873222). Provider just financially supports this study, but does
   not involve all sections of this study, and does not have conflicts
   interest related to this study.
CR Baker H, 2016, LANCET ONCOL, V17, pE275, DOI 10.1016/S1470-2045(16)30241-8
   BELLAMY N, 1988, J RHEUMATOL, V15, P1833
   Boonstra A, 2013, CANCER NURS, V36, P52, DOI 10.1097/NCC.0b013e31824a7e18
   Brauer JA, 2010, J ALTERN COMPLEM MED, V16, P183, DOI 10.1089/acm.2009.0354
   Bruce Bonnie, 2003, Health Qual Life Outcomes, V1, P20, DOI 10.1186/1477-7525-1-20
   Burstein HJ, 2019, J CLIN ONCOL, V37, P423, DOI 10.1200/JCO.18.01160
   Burstein HJ, 2014, J CLIN ONCOL, V32, P2255, DOI 10.1200/JCO.2013.54.2258
   Chien TJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180918
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Condorelli R, 2018, EXPERT REV ANTICANC, V18, P1101, DOI 10.1080/14737140.2018.1520096
   Crew KD, 2007, J CLIN ONCOL, V25, P3877, DOI 10.1200/JCO.2007.10.7573
   Fan HGM, 2010, ANN ONCOL, V21, P983, DOI 10.1093/annonc/mdp394
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hilditch JR, 1996, MATURITAS, V24, P161, DOI 10.1016/0378-5122(96)01038-9
   Hortobagyi GN, 2006, CLIN BREAST CANCER, V6, P391
   Lee HJ, 2009, J EXP CLIN CANC RES, V28, DOI 10.1186/1756-9966-28-102
   Lesi G, 2015, J CLIN ONCOL JCO, V63, P1795
   Liberati A, 2009, ANN INTERN MED, V151, pW65, DOI [10.7326/0003-4819-151-4-200908180-00136, 10.1371/journal.pmed.1000100, 10.1136/bmj.b2700]
   Makubate B, 2013, BRIT J CANCER, V108, P1515, DOI 10.1038/bjc.2013.116
   Momenimovahed Z, 2019, BREAST CANCER-TARGET, V11, P151, DOI 10.2147/BCTT.S176070
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Pan YQ, 2018, INTEGR CANCER THER, V17, P602, DOI 10.1177/1534735418786801
   Partridge AH, 2008, J CLIN ONCOL, V26, P556, DOI 10.1200/JCO.2007.11.5451
   Savard MH, 2009, J PAIN SYMPTOM MANAG, V37, P687, DOI 10.1016/j.jpainsymman.2008.04.010
   Schneider H P, 2000, Climacteric, V3, P50, DOI 10.3109/13697130009167599
   Olid AS, 2013, MED ACUPUNCT, V25, P386, DOI 10.1089/acu.2013.0976
   Shamseer L, 2015, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g7647
   Tedesco D, 2017, JAMA SURG, V152, DOI 10.1001/jamasurg.2017.2872
   Zhu W, 2018, NEUROSCIENCE, V379, P281, DOI 10.1016/j.neuroscience.2018.03.029
NR 30
TC 1
Z9 1
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN
PY 2020
VL 99
IS 24
AR e20567
DI 10.1097/MD.0000000000020567
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MM0WU
UT WOS:000549881200038
PM 32541483
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Cui, LL
   Bai, ZL
AF Cui, Leilei
   Bai, Zhaoliang
TI RETRACTED: Effect of Moxibustion Instrument Combined with Intermediate
   Frequency Electrostatic Therapy on Pain and Joint Function in Elderly
   Patients with Cold-Dampness Knee Arthritis (Retracted Article)
SO COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
LA English
DT Article; Retracted Publication
ID OSTEOARTHRITIS
AB Objective. To explore the effect of a moxibustion instrument combined with intermediate frequency electrostatic therapy on pain and joint function in elderly patients with cold-dampness arthritis (KOA). Method. 200 patients with cold-dampness KOA treated in our hospital from May 2019 to September 2021 were selected. According to the random number table method, they were divided into the observation group (n=100) and control group (n=100). The observation group was treated with moxibustion combined with medium-frequency treatment, and the control group was treated with medium-frequency treatment. The clinical effects of the two groups were compared. The joint functions of the two groups were evaluated by the visualization scale of the osteoarthritis index (WOMAC index) of McMaster University in Western Ontario. The TCM symptom scores of the two groups were evaluated according to the guiding principles for clinical research of new traditional Chinese medicine. The visual analogue scale (VAS) was used to evaluate the pain degree of the two groups, and the microcirculatory blood perfusion (MBPU) and interleukin-1 were compared between the two groups, beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha). The levels of matrix metalloproteinase-1 (MMP-1), serum bone morphogenetic protein-2 (BMP-2), cartilage oligomeric matrix protein (COMP), and serum type II collagen C-terminal peptide (CTX-II) were assessed by the comprehensive quality of life questionnaire-74. Result. The total effective rate of the observation group (92.00%) was higher than that of the control group (76.00%), and the difference was statistically significant (P < 0.05) in beta and TNF-alpha. The levels of MMP-3, BMP-2, comp, and CTX-II and the improvement of quality of life score in the control group were better than those in the control group (P < 0.05). Conclusion. Moxibustion instrument combined with intermediate frequency electrostatic therapy can effectively improve the knee joint function, pain, blood perfusion, inflammatory reaction, and cartilage damage of the elderly patients with cold-dampness-type knee arthritis, and the therapeutic effect is good.
C1 [Cui, Leilei] 971st Navy Hosp Chinese Peoples Liberat Army, Outpatients 1, Qingdao 266071, Shandong, Peoples R China.
   [Bai, Zhaoliang] 971st Hosp, Outpatient Dept, Peoples Liberat Army Navy, Qingdao 266071, Shandong, Peoples R China.
RP Bai, ZL (corresponding author), 971st Hosp, Outpatient Dept, Peoples Liberat Army Navy, Qingdao 266071, Shandong, Peoples R China.
EM 541846434@qq.com; bai19842021@163.com
CR [Anonymous], 2002, Guidelines for Clinical Research on Chinese New Herbal Medicines
   Association, 2018, Chin J Orthop, V38, P11
   Attur M, 2020, ARTHRITIS RES THER, V22, DOI 10.1186/s13075-020-02298-6
   BELLAMY N, 1989, SEMIN ARTHRITIS RHEU, V18, P14, DOI 10.1016/0049-0172(89)90010-3
   Benner RW, 2019, ORTHOP CLIN N AM, V50, P425, DOI 10.1016/j.ocl.2019.05.001
   Bing S., 2012, J NEUROSURG, V28, P645
   Chen JX, 2021, INT J GEN MED, V14, P8481, DOI 10.2147/IJGM.S342435
   Cheng HB, 2020, CARTILAGE, V11, P512, DOI 10.1177/1947603518798884
   Ho KD, 2022, AM J PHYS MED REHAB, V101, P11, DOI 10.1097/PHM.0000000000001730
   Jian-Hui Sun, 2020, Zhongguo Zhong Yao Za Zhi, V45, P4065, DOI 10.19540/j.cnki.cjcmm.20200608.203
   Kan HS, 2019, HONG KONG MED J, V25, DOI 10.12809/hkmj187600
   Lacko M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10245801
   Li J, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016301
   Li PN, 2020, DRUG DELIV, V27, P1034, DOI 10.1080/10717544.2020.1787555
   Lin L, 2020, LASER MED SCI, V35, P823, DOI 10.1007/s10103-019-02863-9
   Lingjiang L., 2009, CLIN METADATA, V24, P763
   Mishra A, 2019, J ORTHOP SURG RES, V14, DOI 10.1186/s13018-019-1391-7
   Primorac D, 2020, GENES-BASEL, V11, DOI 10.3390/genes11080854
   Schell J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090949
   Sharma L, 2021, NEW ENGL J MED, V384, P51, DOI 10.1056/NEJMcp1903768
   Song XY, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000024115
   The State Administration of Traditional Chinese Medicine, 1994, STAND DIAGN EFF TCM
   Wang Mi-Na, 2020, Zhongguo Gu Shang, V33, P388, DOI 10.12200/j.issn.1003-0034.2020.04.020
   Wang X, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019974
   Weili C., 2019, GUANGDONG MED, V40, P2399
   Wu SY, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019541
NR 26
TC 1
Z9 2
U1 0
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1748-670X
EI 1748-6718
J9 COMPUT MATH METHOD M
JI Comput. Math. Method Med.
PD MAY 5
PY 2022
VL 2022
AR 2613901
DI 10.1155/2022/2613901
PG 8
WC Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Mathematical & Computational Biology
GA 1J1FW
UT WOS:000797671100004
PM 35572837
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Benson, S
   Hagen, S
   Hoffmann, O
   Pasler, A
   Bingel, U
   Schedlowski, M
   Peters, J
   Elsenbruch, S
   Frey, UH
AF Benson, Sven
   Hagen, Susanne
   Hoffmann, Oliver
   Pasler, Annika
   Bingel, Ulrike
   Schedlowski, Manfred
   Peters, Juergen
   Elsenbruch, Sigrid
   Frey, Ulrich H.
TI Can a brief psychological expectancy intervention improve postoperative
   pain? A randomized, controlled trial in patients with breast cancer
SO PAIN
LA English
DT Article
DE Postoperative pain; Placebo analgesia; Psychological intervention;
   Positive expectations; Sham acupuncture; Patient-controlled intravenous
   analgesia
ID PLACEBO ANALGESIA; RISK-FACTORS; POSTSURGICAL PAIN; NOCEBO RESPONSES;
   PERSISTENT PAIN; SURGERY; EXPECTATIONS; ACUPUNCTURE; MECHANISMS; RELIEF
AB Pain after surgery remains a major health problem, calling for optimized treatment regimens to maximize the efficacy of pharmacological interventions. In this randomized controlled trial, we tested in a routine surgical treatment setting whether postoperative pain can be reduced by a brief preoperative intervention, ie, positive verbal suggestions in combination with sham acupuncture, designed to optimize treatment expectations. We hypothesized that the expectancy intervention as add-on to patient-controlled intravenous analgesia with morphine reduces patient-reported postoperative pain and improves satisfaction with analgesia. Ninety-six women undergoing breast cancer surgery were randomized at 2 stages: Before surgery, anesthesiologists delivered either positive or neutral verbal suggestions regarding the benefits of acupuncture needling on postoperative pain ("information condition"). Patients were then randomized to receive sham acupuncture or no sham acupuncture during postoperative care ("sham acupuncture condition"). Average pain during the 24-hour observation period after surgery as primary and satisfaction with analgesia as secondary outcome was assessed with standardized measures and analyzed with analysis of covariance accounting for morphine dose, surgery-related, and psychological parameters. Postoperative pain ratings were significantly reduced in patients who received positive treatment-related suggestions (F = 4.45, P = 0.038, main effect of information). Moreover, patients who received an intervention aimed at optimized treatment expectations reported significantly greater satisfaction with analgesia (F = 4.89, P = 0.030, interaction effect). Together, our proof-of-concept data support that optimizing treatment expectations through verbal suggestions may offer a promising approach to improve patient-reported outcomes. Future translational and clinical studies are needed to test such psychological strategies in different surgical interventions, patient groups, and pharmacological treatment regimens.
C1 [Benson, Sven; Pasler, Annika; Schedlowski, Manfred; Elsenbruch, Sigrid] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Psychol & Behav Immunobiol, Essen, Germany.
   [Hagen, Susanne; Pasler, Annika; Peters, Juergen; Frey, Ulrich H.] Univ Duisburg Essen, Univ Hosp Essen, Klin Anasthesiol & Intens Med, Essen, Germany.
   [Hoffmann, Oliver] Univ Duisburg Essen, Univ Hosp Essen, Clin Obstet & Gynecol, Essen, Germany.
   [Bingel, Ulrike] Univ Duisburg Essen, Univ Hosp Essen, Clin Neurol, Essen, Germany.
   [Frey, Ulrich H.] Ruhr Univ Bochum, Marienhosp Herne, Dept Anesthesiol, Bochum, Germany.
C3 University of Duisburg Essen; University of Duisburg Essen; University
   of Duisburg Essen; University of Duisburg Essen; Ruhr University Bochum;
   St. Marien Hospital
RP Benson, S (corresponding author), Univ Hosp Essen, Inst Med Psychol & Behav Immunobiol, Hufelandstr 55, D-45122 Essen, Germany.
EM sven.benson@uk-essen.de
RI ; Schedlowski, Manfred/GLU-7519-2022; Benson, Sven/I-1981-2014; Frey,
   Ulrich/C-2752-2019
OI Elsenbruch, Sigrid/0000-0002-6528-2665; Benson,
   Sven/0000-0002-4487-4258; Frey, Ulrich/0000-0003-2961-6629
FU Stiftung Universitatsmedizin, Essen, Germany
FX The study was funded by Stiftung Universitatsmedizin, Essen, Germany.
   The funding source had no influence on study conduct and study report.
CR Amanzio M, 2001, PAIN, V90, P205, DOI 10.1016/S0304-3959(00)00486-3
   Andersen KG, 2011, J PAIN, V12, P725, DOI 10.1016/j.jpain.2010.12.005
   Annoni M, 2018, INT REV NEUROBIOL, V139, P463, DOI 10.1016/bs.irn.2018.07.031
   Apfelbaum JL, 2003, ANESTH ANALG, V97, P534, DOI 10.1213/01.ANE.0000068822.10113.9E
   Atlas LY, 2012, J NEUROSCI, V32, P8053, DOI 10.1523/JNEUROSCI.0383-12.2012
   Barnett SF, 2013, ANESTHESIOLOGY, V119, P452, DOI 10.1097/ALN.0b013e3182976014
   Benedetti F, 2013, PHYSIOL REV, V93, P1207, DOI 10.1152/physrev.00043.2012
   Bingel U, 2014, JAMA-J AM MED ASSOC, V312, P693, DOI 10.1001/jama.2014.8342
   Bingel U, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3001244
   Brody H, 2011, JAMA-J AM MED ASSOC, V306, P2612, DOI 10.1001/jama.2011.1850
   Büchel C, 2014, NEURON, V81, P1223, DOI 10.1016/j.neuron.2014.02.042
   Chow A, 2009, SURGERY, V146, P435, DOI 10.1016/j.surg.2009.03.019
   Colloca L, 2018, INT REV NEUROBIOL, V138, P219, DOI 10.1016/bs.irn.2018.01.005
   Colloca L, 2013, PAIN, V154, P511, DOI 10.1016/j.pain.2013.02.002
   Diaz JJH, 2016, HAND SURG REHABIL, V35, P413, DOI 10.1016/j.hansur.2016.08.008
   Enck P, 2013, NAT REV DRUG DISCOV, V12, P191, DOI 10.1038/nrd3923
   Finniss DG, 2010, LANCET, V375, P686, DOI 10.1016/S0140-6736(09)61706-2
   Gärtner R, 2009, JAMA-J AM MED ASSOC, V302, P1985, DOI 10.1001/jama.2009.1568
   Joshi Girish P, 2005, Anesthesiol Clin North Am, V23, P21, DOI 10.1016/j.atc.2004.11.013
   Kam-Hansen S, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3006175
   Kaptchuk TJ, 2008, BMJ-BRIT MED J, V336, P999, DOI 10.1136/bmj.39524.439618.25
   Kaptchuk TJ, 2006, BMJ-BRIT MED J, V332, P391, DOI 10.1136/bmj.38726.603310.55
   Katz J, 2005, PAIN, V119, P16, DOI 10.1016/j.pain.2005.09.008
   Kaunisto MA, 2013, ANESTHESIOLOGY, V119, P1410, DOI 10.1097/ALN.0000000000000012
   Kehlet H, 2006, LANCET, V367, P1618, DOI 10.1016/S0140-6736(06)68700-X
   Kessner S, 2013, JAMA INTERN MED, V173, P1468, DOI 10.1001/jamainternmed.2013.6705
   Klinger R, 2014, PAIN, V155, P1055, DOI 10.1016/j.pain.2013.12.007
   Lehmann N, 2010, BRIT J ANAESTH, V105, P511, DOI 10.1093/bja/aeq186
   LEVINE JD, 1984, NATURE, V312, P755, DOI 10.1038/312755a0
   Linde K, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-75
   Löwe B, 2010, J AFFECT DISORDERS, V122, P86, DOI 10.1016/j.jad.2009.06.019
   Luszczynska A, 2005, J PSYCHOL, V139, P439, DOI 10.3200/JRLP.139.5.439-457
   McNicol ED, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003348.pub3
   Meissner K, 2013, JAMA INTERN MED, V173, P1941, DOI 10.1001/jamainternmed.2013.10391
   Peerdeman KJ, 2016, PAIN, V157, P1179, DOI 10.1097/j.pain.0000000000000540
   Petrovic P, 2002, SCIENCE, V295, P1737, DOI 10.1126/science.1067176
   Pollo A, 2001, PAIN, V93, P77, DOI 10.1016/S0304-3959(01)00296-2
   Powell R, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008646.pub2
   Rehberg B, 2017, CLIN J PAIN, V33, P57, DOI 10.1097/AJP.0000000000000380
   Rief W, 2017, BMC MED, V15, DOI 10.1186/s12916-016-0767-3
   Roderigo T, 2017, PAIN, V158, P1489, DOI 10.1097/j.pain.0000000000000940
   Schedlowski M, 2015, PHARMACOL REV, V67, P697, DOI 10.1124/pr.114.009423
   Schmid J, 2015, GUT, V64, P418, DOI 10.1136/gutjnl-2013-306648
   Sipilä RM, 2017, PAIN, V158, P922, DOI 10.1097/j.pain.0000000000000859
   Street RL, 2012, PATIENT EDUC COUNS, V89, P245, DOI 10.1016/j.pec.2012.06.032
   Suarez-Almazor ME, 2010, ARTHRIT CARE RES, V62, P1229, DOI 10.1002/acr.20225
   Usichenko TI, 2005, PAIN, V114, P320, DOI 10.1016/j.pain.2004.08.021
   Wager TD, 2015, NAT REV NEUROSCI, V16, P403, DOI 10.1038/nrn3976
   Wang Y, 2018, INT J SURG, V52, P50, DOI 10.1016/j.ijsu.2018.02.032
   Weiser TG, 2008, LANCET, V372, P139, DOI 10.1016/S0140-6736(08)60878-8
   Wiech K, 2016, SCIENCE, V354, P584, DOI 10.1126/science.aaf8934
   Zunhammer M, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aal2999
NR 52
TC 26
Z9 28
U1 0
U2 32
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD JUL
PY 2019
VL 160
IS 7
BP 1562
EP 1571
DI 10.1097/j.pain.0000000000001546
PG 10
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anesthesiology; Neurosciences & Neurology
GA IQ5AO
UT WOS:000480763500010
PM 30839426
DA 2026-01-16
ER

PT J
AU Chien, A
   Yang, CC
   Chang, SC
   Jan, YM
   Yang, CH
   Hsieh, YL
AF Chien, Andy
   Yang, Chen-Chia
   Chang, Sheng-Chi
   Jan, Yi-Min
   Yang, Ching-Hsiang
   Hsieh, Yueh-Ling
TI Ultrasound Acupuncture for Oxaliplatin-induced Peripheral Neuropathy in
   Patients With Colorectal Cancer: A Pilot Study
SO PM&R
LA English
DT Article
ID QUALITY-OF-LIFE; NERVE SURGERY; CHEMOTHERAPY; PAIN; THERAPY;
   FEASIBILITY; STIMULATION; RECOVERY; MODEL
AB Background Oxaliplatin is frequently used in the treatment of metastatic colorectal cancer. However, peripheral neuropathy is a severe adverse effect of oxaliplatin that may persist and impact quality of life.
   Objective To assess the potential effects of ultrasound acupuncture for the alleviation of symptoms related to oxaliplatin-induced peripheral neuropathy (OIPN) among patients with metastatic colorectal cancer.
   Design Prospective cohort pilot study.
   Setting Education and research hospital.
   Participants Patients with a diagnosis of stage II-IV colorectal cancer undergoing oxaliplatin-based treatment regimens who experienced OIPN symptoms (n = 17).
   Interventions Pulsed therapeutic ultrasound (1 MHz) at bilateral acupuncture points of PC6, PC7, BL60, and KI1 was administered for 5 minutes per point daily for 12 days.
   Main Outcome Measurements Pain Quality Assessment Scale (PQAS), Chemotherapy-induced Neurotoxicity Questionnaire (CINQ), quantitative touch-detection threshold, cold-trigger pain withdrawal latency, and quality of life (EORTC QLQ-C30) were measured at baseline (day 0), pre-intervention (day 12, post wash-out period), post-intervention (day 24), and final follow-up (day 54). A P value of less than .05 was considered statistically significant.
   Results Scores of PQAS and CINQ significantly improved after ultrasound acupuncture at post-intervention and follow-up compared to both baseline and pre-intervention. Similar trends were also observed for the quantitative sensory testing, where touch-detection threshold significantly decreased and cold-trigger pain withdrawal latency significantly increased after ultrasound acupuncture. Patients also showed an improvement on quality of life outcomes as measured by QLQ-C30 post-intervention and at follow-up.
   Conclusions Ultrasound acupuncture could be an effective intervention for OIPN symptoms for patients with colorectal cancer. However, larger and randomized clinical trials with placebo controls are needed to confirm such effects.
C1 [Chien, Andy; Yang, Ching-Hsiang; Hsieh, Yueh-Ling] China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, Taichung, Taiwan.
   [Yang, Chen-Chia] Kao An Rehabil & Pain Clin, Taichung, Taiwan.
   [Chang, Sheng-Chi] China Med Univ Hosp, Dept Colorectal Surg, Taichung, Taiwan.
   [Jan, Yi-Min] China Med Univ, Ctr Gen Educ, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan
RP Hsieh, YL (corresponding author), China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, Taichung, Taiwan.
EM sherrie@mail.cmu.edu.tw
OI Hsieh, Yueh-Ling/0000-0002-8507-170X
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   Akhlaghi Zhamak, 2012, Iranian Biomedical Journal, V16, P107, DOI 10.6091/IBJ.942.2012
   An KE, 2010, NEUROL RES, V32, pS22, DOI 10.1179/016164109X12537002793760
   Bergmeister KD, 2018, NEURAL REGEN RES, V13, P1530, DOI 10.4103/1673-5374.237113
   Chang WD, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6568976
   Chang YW, 2014, BMC MUSCULOSKEL DIS, V15, DOI 10.1186/1471-2474-15-399
   Chen CC, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016516
   Chen Ling, 2017, Zhongguo Zhen Jiu, V37, P479, DOI 10.13703/j.0255-2930.2017.05.007
   Clark RJ, 2012, ACUPUNCT MED, V30, P298, DOI 10.1136/acupmed-2012-010183
   Colquhoun D, 2013, ANESTH ANALG, V116, P1360, DOI 10.1213/ANE.0b013e31828f2d5e
   Daeschler SC, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21540-5
   Deng SZ, 2015, EXP THER MED, V10, P1247, DOI 10.3892/etm.2015.2653
   Dimitrova A, 2020, PAIN MED, V21, pE232, DOI 10.1093/pm/pnz276
   Ding Ming-hui, 2009, Zhongguo Zhen Jiu, V29, P603
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Ernst E, 2006, J INTERN MED, V259, P125, DOI 10.1111/j.1365-2796.2005.01584.x
   Ernst E, 2011, PAIN, V152, P755, DOI 10.1016/j.pain.2010.11.004
   Fayers P., 1995, EORTC QLQC30 scoring manual. European organisation for research and treatment of cancer
   Fu Taofang, 2017, Zhongguo Zhen Jiu, V37, P513, DOI 10.13703/j.0255-2930.2017.05.017
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   He Y, 2019, JAMA ONCOL
   Hou S, 2018, PAIN PHYSICIAN, V21, P571, DOI 10.36076/ppj.2018.6.571
   Hsieh YL, 2016, SUPPORT CARE CANCER, V24, P233, DOI 10.1007/s00520-015-2773-y
   Hsieh YL, 2017, ULTRASOUND MED BIOL, V43, P1466, DOI 10.1016/j.ultrasmedbio.2017.03.002
   Hsieh YL, 2016, ACUPUNCT MED, V34, P398, DOI 10.1136/acupmed-2016-011112
   Hsieh YL, 2012, J COMP NEUROL, V520, P2903, DOI 10.1002/cne.23072
   Leonard GD, 2005, BMC CANCER, V5, DOI 10.1186/1471-2407-5-116
   Lu WD, 2012, MED ACUPUNCT, V24, P233, DOI 10.1089/acu.2012.0904
   Macklin EA, 2006, HYPERTENSION, V48, P838, DOI 10.1161/01.HYP.0000241090.28070.4c
   McQuade RM, 2017, CURR MED CHEM, V24, P1537, DOI 10.2174/0929867324666170111152436
   Mei Jun-hua, 2015, Zhongguo Zhong Xi Yi Jie He Za Zhi, V35, P1463
   Mi Yi-Qun, 2009, Zhongguo Zhen Jiu, V29, P48
   Pachman DR, 2016, SUPPORT CARE CANCER, V24, P5059, DOI 10.1007/s00520-016-3373-1
   Pulvers JN, 2017, ASIA-PAC J CLIN ONCO, V13, P345, DOI 10.1111/ajco.12694
   Qin Yu-ge, 2010, Zhongguo Zhen Jiu, V30, P121
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Seco J, 2011, SPINE J, V11, P966, DOI 10.1016/j.spinee.2011.02.002
   Tofthagen C, 2013, SUPPORT CARE CANCER, V21, P3307, DOI 10.1007/s00520-013-1905-5
   Tsuruoka N, 2019, COMPLEMENT MED RES, V26, P404, DOI 10.1159/000501149
   Tsuruta A, 2016, DRUG DES DEV THER, V10, P3827, DOI 10.2147/DDDT.S112322
   Wong Raimond, 2006, Acupunct Med, V24, P87
   Xu Wei-Ru, 2010, Zhongguo Zhen Jiu, V30, P457
   Yang Yu-Hua, 2012, Zhen Ci Yan Jiu, V37, P333
   Yoo SS, 2014, COMPLEMENT THER MED, V22, P592, DOI 10.1016/j.ctim.2014.05.010
   Zeng YJ, 2018, LASER MED SCI, V33, P295, DOI 10.1007/s10103-017-2367-7
   Zhang WP, 2010, J ACUPUNCT MERIDIAN, V3, P43, DOI 10.1016/S2005-2901(10)60007-6
   Zhao Jian-ling, 2008, Zhongguo Zhen Jiu, V28, P13
NR 47
TC 5
Z9 5
U1 2
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1934-1482
EI 1934-1563
J9 PM&R
JI PM&R
PD JAN
PY 2021
VL 13
IS 1
BP 55
EP 65
DI 10.1002/pmrj.12361
EA APR 2020
PG 11
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation; Sport Sciences
GA PW3CS
UT WOS:000526959500001
PM 32168417
DA 2026-01-16
ER

PT J
AU Wei, JQ
   Yang, ZH
   Lin, QT
   Xu, HY
   Lai, F
   Han, Y
   Li, J
   Cui, S
AF Wei, Jinqiang
   Yang, Zihong
   Lin, Qiutian
   Xu, Haiyan
   Lai, Fang
   Han, Yun
   Li, Jun
   Cui, Shuai
TI Bibliometric and visualized analysis of electroacupuncture in the past
   10 years
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Electroacupuncture; CiteSpace; Research status; Cooperation
ID INDUCED NEUROPATHIC PAIN; IRRITABLE-BOWEL-SYNDROME; SPINAL-CORD;
   RESEARCH TRENDS; ACUPUNCTURE THERAPY; STEM-CELLS; RATS; INJURY;
   MECHANISMS; EXPRESSION
AB Background: There are many studies that have interrogated the evolution and use of electroacupuncture (EA). We aimed to evaluate the research status, cooperation and development of EA in the past 10 years. Methods: We obtained data on the EA from the Web of Science core collection database. CiteSpace 5.7. R1 software was used to assess research cooperation through analysis of authors, institutions and countries. In addition, keyword cluster analysis, references and burst detection were analyzed to explore research hotspots and trends in the field of EA. Results: We included a total of 3019 citing literature and 78,235 cited literature for analysis. The data showed that there has been a rise in the global number of EA studies in the past decade. Besides, the data demonstrated that China has made outstanding contribution in the development of EA. Whereas there is inter-agency cooperation in China, there is less cooperation with other countries. In addition, we showed frequent use of keywords such as "expression", "stimulation", or "pain". Besides, neuroscience was the main research area, followed by general medicine and oncology. Furthermore, with the improved research methods and technologies, there is enhanced overall quality of the studies. Conclusion: Taken together, our findings demonstrate a steady increase in the studies involving EA. However, the studies are unevenly distributed among countries and thus there is need for closer international cooperation.
C1 [Wei, Jinqiang; Yang, Zihong; Lin, Qiutian; Lai, Fang; Han, Yun; Li, Jun] Guangzhou Univ Chinese Med, Clin Coll 2, 36 Yongan St, Guangzhou, Guangdong, Peoples R China.
   [Xu, Haiyan] Guangzhou Univ Chinese Med, Clin Coll 7, Guangzhou, Peoples R China.
   [Lai, Fang; Han, Yun; Li, Jun] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
   [Cui, Shuai] Anhui Univ Chinese Med, Res Inst Acupuncture & Meridian, Hefei, Peoples R China.
   [Cui, Shuai] Guangzhou Univ Chinese Med, Med Coll Acupuncture Moxibust & Rehabil, South China Res Ctr Acupuncture & Moxibust, Guangzhou, Peoples R China.
   [Lai, Fang; Han, Yun] Guangdong Prov Hosp Chinese Med, Chao En Xiang Famous Chinese Med Expert Inheritan, Guangzhou, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine; Anhui
   University of Chinese Medicine; Guangzhou University of Chinese
   Medicine; Guangzhou University of Chinese Medicine
RP Lai, F (corresponding author), Guangzhou Univ Chinese Med, Clin Coll 2, 36 Yongan St, Guangzhou, Guangdong, Peoples R China.
EM 13016090@qq.com
RI Zihong, Yang/MYS-6051-2025; Lai, Fang/D-6601-2014
FU National Natural Science Foundation of China [81703856]; Guangdong
   Provincial Key Laboratory of Research on Emergency in TCM
   [2017B030314176]
FX This work was supported by the National Natural Science Foundation of
   China (Grant no. 81703856) and Guangdong Provincial Key Laboratory of
   Research on Emergency in TCM (Grant 2017B030314176).
CR Burnstock G, 2014, SCIENCE, V346, pS23
   Chen CM, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0223994
   Chen CM, 2006, J AM SOC INF SCI TEC, V57, P359, DOI 10.1002/asi.20317
   Chen YY, 2008, ACUPUNCTURE ELECTRO, V33, P19, DOI 10.3727/036012908803861212
   Choi DC, 2010, NEUROBIOL DIS, V39, P272, DOI 10.1016/j.nbd.2010.04.003
   Choi JW, 2015, AM J CHINESE MED, V43, P57, DOI 10.1142/S0192415X15500044
   Fang JQ, 2018, LIFE SCI, V200, P69, DOI 10.1016/j.lfs.2018.03.028
   Goldman N, 2010, NAT NEUROSCI, V13, P883, DOI 10.1038/nn.2562
   Han JS, 2011, PAIN, V152, pS41, DOI 10.1016/j.pain.2010.10.012
   Harbi SA, 2020, NAT MED, V9, P1, DOI DOI 10.1038/s41591-020-0897-1
   Huang C, 2002, BRAIN RES, V945, P20, DOI 10.1016/S0006-8993(02)02503-9
   Huang L, 2021, J PAIN RES, V14, P343, DOI 10.2147/JPR.S292657
   Huang WJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032960
   Jia LL, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/9187406
   Jia XJ., 2016, CHIN ARCH TRAD CHIN, V34, P1404
   Jin YX, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8875433
   Law SK, 2015, AM J OPHTHALMOL, V160, P256, DOI 10.1016/j.ajo.2015.04.033
   Li J., 2017, CiteSpace: Text Mining and Visualization in Scientific Literature, V2nd
   Li LL, 2018, CHIN J INTEGR MED, V24, P822, DOI 10.1007/s11655-017-2924-8
   Li RR, 2020, J PAIN RES, V13, P1901, DOI 10.2147/JPR.S258739
   Li XY, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-37
   Lin JG, 2002, PAIN, V99, P509, DOI 10.1016/S0304-3959(02)00261-0
   Lu CC, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00294
   Lu KW, 2016, SCI REP-UK, V6, DOI 10.1038/srep22123
   Lu YW, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/3901528
   Mao CL, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/7486041
   Mao XJ, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000020137
   Miao M, 2020, CHIN J MED SCI RES M, V33, P249
   Nardini C, 2014, SCIENCE, V346, pS21
   Ning YZ, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000022068
   Qu ZY, 2020, J PAIN RES, V13, P25, DOI 10.2147/JPR.S226922
   Shi XH, 2021, BRAIN BEHAV, V11, DOI 10.1002/brb3.1927
   Song YF, 2020, AM J CHINESE MED, V48, P77, DOI 10.1142/S0192415X20500044
   Song YY, 2020, CHIN J INTEGR MED, V26, P473, DOI 10.1007/s11655-020-3092-9
   Torres-Rosas R, 2014, NAT MED, V20, P291, DOI 10.1038/nm.3479
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Wang WH, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/5419407
   Wang Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059449
   Wang YJ, 2019, BIOL RES NURS, V21, P5, DOI 10.1177/1099800418804896
   Wu L, 2021, ANN PALLIAT MED, V10, P3194, DOI 10.21037/apm-21-477
   Xing D, 2018, INT J RHEUM DIS, V21, P1372, DOI 10.1111/1756-185X.13327
   Xiong L, 2003, CHINESE MED J-PEKING, V116, P108
   Xu M, 2019, CHIN HOSP MANAG, V39
   Xue M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186524
   Yang FM, 2020, CHIN J INTEGR MED, V26, P310, DOI 10.1007/s11655-019-3150-3
   Yang Y, 2020, NEUROREPORT, V31, P1072, DOI 10.1097/WNR.0000000000001518
   Yao LM, 2020, CHEMOSPHERE, V245, DOI 10.1016/j.chemosphere.2019.125627
   Yeo S, 2014, BMC COMPLEM ALTERN M, P14
   Yeung WF, 2011, SLEEP, V34, P807, DOI 10.5665/SLEEP.1056
   Zhan J, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-017153
   Zhang JH, 2021, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.620555
   Zhang JY, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/9786482
   Zhang JF, 2017, MOL MED REP, V16, P2185, DOI 10.3892/mmr.2017.6801
   Zhang RX, 2014, ANESTHESIOLOGY, V120, P482, DOI 10.1097/ALN.0000000000000101
   Zhang Y, 2020, J KING SAUD UNIV SCI, V32, P1366, DOI 10.1016/j.jksus.2019.11.029
   Zhang YY, 2020, CHIN J INTEGR MED
   Zhao JM, 2018, CHIN J INTEGR MED, V24, P328, DOI 10.1007/s11655-018-2838-0
   Zhao TT, 2021, J PAIN RES, V14, P1399, DOI 10.2147/JPR.S306594
   Zhao YX, 2020, J PAIN RES, V13, P239, DOI 10.2147/JPR.S241101
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zheng Y, 2020, NEURAL PLAST, V2020, DOI 10.1155/2020/8818328
   Zheng YY, 2020, BRAIN RES BULL, V162, P1, DOI 10.1016/j.brainresbull.2020.04.020
   Zheng Z, 2019, PAIN MED, V20, P397, DOI 10.1093/pm/pny113
   Zhong YJ, 2020, J TRADIT CHIN MED, V40, P707, DOI 10.19852/j.cnki.jtcm.2020.05.001
   Zhou J, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/7491281
   Zhou X, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/9254503
   Zhou ZD, 2020, MOL MED REP, V22, P751, DOI 10.3892/mmr.2020.11161
   Zhu Y, 2017, BRAIN RES BULL, V131, P123, DOI 10.1016/j.brainresbull.2017.04.003
   Zhu YZ, 2012, NEURAL REGEN RES, V7, P207, DOI 10.3969/j.issn.1673-5374.2012.03.009
   Zou F, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8839491
NR 70
TC 6
Z9 7
U1 2
U2 105
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD OCT
PY 2022
VL 69
AR 102846
DI 10.1016/j.ctim.2022.102846
EA JUN 2022
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 2T5KG
UT WOS:000822512800003
PM 35688327
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhong, ZN
   Jin, K
   Qin, FL
   Nie, RR
AF Zhong, Zhinian
   Jin, Kang
   Qin, Fengling
   Nie, Rongrong
TI Huoxue Tongluo decoction combined with acupuncture in the treatment of
   lumbar disc herniation and its effect on JOA and VAS scores
SO JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION
LA English
DT Article
DE Clinical disease; effectiveness; functional recovery
ID PAIN; DISKECTOMY
AB BACKGROUND: Lumbar disc herniation (LDH) is a common clinical disease of the skeletal system, and its prevalence has been on a rise.
   OBJECTIVE: To evaluate the efficacy of Huoxue Tongluo decoction plus acupuncture in the treatment of lumbar disc herniation and its effectiveness in improving the functional recovery of the patients' affected joints and mitigating their pain.
   METHODS: In this prospective study, 110 patients with lumbar disc herniation enrolled in our Hospital from June 2019 to June 2021 were collected and randomized to receive either conventional treatment (control group) or Huoxue Tongluo Decoction plus acupuncture (study group).
   RESULTS: Huoxue Tongluo Decoction plus acupuncture resulted in more rapid mitigation of lower extremity symptoms and lumbar symptoms versus conventional treatment (P < 0.05). Patients receiving traditional Chinese medicine (TCM) showed milder inflammatory responses than those with conventional medication, as evidenced by the lower serum concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and high-sensitivity C-reactive protein (hs-CRP) (P < 0.05). After treatment, the study group had higher Japanese Orthopedic Association (JOA) scores and lower visual analogue scale (VAS) scores than the control group (P < 0.05), suggesting that the combination of the herbal decoction and acupuncture provided better functional recovery of the affected joints and pain mitigation for the patients. Furthermore, the lower Pittsburgh sleep quality index (PSQI) scores in patients in the study group indicated better sleep quality of patients after TCM intervention than after conventional treatment (P < 0.05). Huoxue Tongluo Decoction plus acupuncture was associated with a significantly higher efficacy (94.55%) versus conventional treatment (80%) (P < 0.05).
   CONCLUSIONS: Huoxue Tongluo Decoction combined with acupuncture significantly offers a viable treatment alternative for lumbar disc herniation with promising treatment outcomes, mitigates patients' limb pain, and improves their lumbar function and sleep quality. Further trials are, however, required prior to general application in clinical practice.
C1 [Zhong, Zhinian; Jin, Kang] Tradit Chinese Med Hosp Qinzhou, Dept Rehabil Med, Qinzhou, Guangxi, Peoples R China.
   [Qin, Fengling; Nie, Rongrong] Guilin Med Coll, Dept Rehabil Treatment, Affiliated Hosp, Guilin, Guangxi, Peoples R China.
C3 Guilin Medical University
RP Nie, RR (corresponding author), Guilin Med Coll, Dept Rehabil Treatment, Affiliated Hosp, Guilin, Guangxi, Peoples R China.
EM ronguiwvto865@163.com
FU The scientific research and technology development plan project in
   Qinzhou [20212609]; The scientific research and technology development
   plan project in Guilin [20210227-7-3]
FX The study was supported by 'The scientific research and technology
   development plan project in Qinzhou' (Contract no. 20212609) and 'The
   scientific research and technology development plan project in Guilin'
   (Contract no. 20210227-7-3).
CR Ahn Y, 2016, CLIN NEUROL NEUROSUR, V147, P11, DOI 10.1016/j.clineuro.2016.05.016
   Ahsan K, 2021, J CRANIOVERTEBRAL JU, V12, P44, DOI 10.4103/jcvjs.JCVJS_153_20
   Ahsan Md Kamrul, 2020, Surg Neurol Int, V11, P404, DOI [10.25259/sni_540_2020, 10.25259/SNI_540_2020]
   Cai CY, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/6754730
   Han LH, 2020, BIOMED PHARMACOTHER, V125, DOI 10.1016/j.biopha.2020.109998
   Ishibashi Y, 2020, J ORTHOP SCI, V25, P6, DOI 10.1016/j.jos.2019.10.009
   Javanshir N, 2017, EUR SPINE J, V26, P3135, DOI 10.1007/s00586-017-5219-z
   Li K-M, 2020, Journal of Hainan Medical University, V26, P16
   Lurie JD, 2013, SPINE, V38, P1216, DOI 10.1097/BRS.0b013e31828ce66d
   Mo ZM, 2018, J MANIP PHYSIOL THER, V41, P771, DOI 10.1016/j.jmpt.2018.04.005
   Moon Myung-Sang, 2016, Journal of Musculoskeletal Research, V19, P1650016, DOI [10.1142/s0218957716500160, 10.1142/S0218957716500160]
   Qin RQ, 2018, WORLD NEUROSURG, V120, P352, DOI 10.1016/j.wneu.2018.08.236
   Radcliff K, 2013, SPINE, V38, pE849, DOI 10.1097/BRS.0b013e3182959e4e
   Sadek AR, 2019, BRIT J NEUROSURG, V33, P586, DOI 10.1080/02688697.2017.1394445
   Sun K, 2020, Journal of Hainan Medical University, V26, P32
   Sung YT, 2018, BEHAV RES METHODS, V50, P1694, DOI 10.3758/s13428-018-1041-8
   Suri P, 2017, SPINE, V42, P755, DOI 10.1097/BRS.0000000000001894
   Tang YZ, 2013, CHINESE MED J-PEKING, V126, P4691, DOI 10.3760/cma.j.issn.0366-6999.20132074
   Tsarouhas A, 2017, MOL MED REP, V15, P2195, DOI 10.3892/mmr.2017.6221
   Xu HH, 2013, CHINESE MED J-PEKING, V126, P2840, DOI 10.3760/cma.j.issn.0366-6999.20130310
   Yin ZH, 2020, TRADIT MED RES, V5, P282, DOI 10.12032/TMR20190930137
   Yu PF, 2014, ORTHOP SURG, V6, P229, DOI 10.1111/os.12120
   Zhang W, 2013, AM J CHINESE MED, V41, P983, DOI 10.1142/S0192415X13500663
   Zhong Y, 2018, Neuropeptides: An International Journal, P7230
   Zhou Z, 2021, ORTHOP SURG, V13, P979, DOI 10.1111/os.12862
NR 25
TC 2
Z9 3
U1 2
U2 11
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1053-8127
EI 1878-6324
J9 J BACK MUSCULOSKELET
JI J. Back Musculoskelet. Rehabil.
PY 2024
VL 37
IS 2
BP 277
EP 283
DI 10.3233/BMR-220347
PG 7
WC Orthopedics; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rehabilitation
GA OP8B7
UT WOS:001208560100004
PM 37661864
DA 2026-01-16
ER

PT J
AU Jeong, YJ
   Kwak, MA
   Seo, JC
   Park, SH
   Bong, JG
   Shin, IH
   Parkwo, SH
AF Jeong, Young Ju
   Kwak, Min Ah
   Seo, Jung Chul
   Park, Seong Hoon
   Bong, Jin Gu
   Shin, Im Hee
   Parkwo, Sung Hwan
TI Acupuncture for the Treatment of Taxane-Induced Peripheral Neuropathy in
   Breast Cancer Patients: A Pilot Trial
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID MANAGEMENT; EFFICACY; ONCOLOGY; PAIN
AB Objectives. Some chemotherapy drugs can damage the nerves and cause peripheral neuropathy which is accompanied by severe neuropathic pain or gait impairment. The purpose of this study was to assess the feasibility and the safety of acupuncture for the treatment of peripheral neuropathy following chemotherapy in Korean breast cancer patients. Design. This study was a prospective single-arm observational study using before and after measurements in breast cancer patients presenting with taxane-induced peripheral neuropathy. Settings/Location. This study was performed at East-West Medical Center at Daegu Catholic University Hospital, Daegu, South Korea. Interventions. Acupuncture was administered 3 times a week for 4 consecutive weeks, for 25 +/- 5 minutes at each session. Outcome Measures. The primary outcome measure was severity of CIPN using the Neuropathic Pain Symptom Inventory (NPSI) assessed by a self-administered questionnaire and Nerve Conduction Study (NCS) of extremities. The secondary outcome measure was quality of life (QoL) assessed by a self-administered questionnaire using the 36-Item Short From Health Survey (SF-36). Results. Acupuncture significantly reduced the severity of CIPN assessed by NPSI score. Four weeks after the last treatment, the symptoms were not aggravated. According to NCS, 42.9% of participants showed improvement of sensory neuropathy. At the end of the treatment, SF-36 scores were significantly increased for variables including physical functioning, role limitations due to physical health problems, social functioning, and general health perceptions compared to those of baseline measurement. Conclusions. Acupuncture improved symptoms of CIPN and QoL in Korean women suffering from peripheral neuropathy after chemotherapy using taxane for breast cancer. The effects of acupuncture lasted for at least 1 month after the treatment.
C1 [Jeong, Young Ju; Parkwo, Sung Hwan] Catholic Univ Daegu, Sch Med, Dept Surg, Daegu, South Korea.
   [Kwak, Min Ah] Daegu Haany Univ, Coll Oriental Med, Dept Oriental Internal Med, Daegu, South Korea.
   [Seo, Jung Chul; Park, Seong Hoon] Comprehens & Integrat Med Inst, Daegu, South Korea.
   [Bong, Jin Gu] Raphael Hosp, Dept Surg, Daegu, South Korea.
   [Shin, Im Hee] Catholic Univ Daegu, Sch Med, Dept Med Stat, Daegu, South Korea.
C3 Catholic University of Daegu; Daegu Haany University; Catholic
   University of Daegu
RP Park, SH (corresponding author), Comprehens & Integrat Med Inst, Daegu, South Korea.
EM shwpark@cu.ac.kr
OI Jeong, Young Ju Jeong/0000-0002-7005-0850; 박, 성환/0000-0002-7225-1250
FU Ministry of Health and Welfare, Republic of Korea
   [090-091-3000-3038-301-320-01]
FX This study was supported by a grant of the Ministry of Health and
   Welfare, Republic of Korea (Project no.090-091-3000-3038-301-320-01).
CR Addington James, 2016, F1000Res, V5, DOI [10.12688/f1000research.8053.1, 10.12688/f1000research.8053.1]
   [Anonymous], 2017, BREAST CANC FACTS FI
   [Anonymous], 2007, MANUAL ACUPUNCTURE
   [Anonymous], 2013, TRIALS, DOI DOI 10.1186/1745-6215-14-254
   [Anonymous], EVID BASED COMPLEMEN
   [Anonymous], 2012, EST CANC INC MORT PR
   Bao T, 2011, PAIN RES TREAT, V2011, DOI 10.1155/2011/920807
   Ben-Arye E, 2016, COMPLEMENT THER MED, V29, P9, DOI 10.1016/j.ctim.2016.09.001
   Ben-Horin I, 2017, INTEGR CANCER THER, V16, P258, DOI 10.1177/1534735417690254
   Bouhassira D, 2004, PAIN, V108, P248, DOI 10.1016/j.pain.2003.12.024
   Brami C, 2016, CRIT REV ONCOL HEMAT, V98, P325, DOI 10.1016/j.critrevonc.2015.11.014
   Dimitrova A, 2017, J ALTERN COMPLEM MED, V23, P164, DOI 10.1089/acm.2016.0155
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Gradishar WJ, 2012, BREAST CANCER-BASIC, V6, P159, DOI 10.4137/BCBCR.S8205
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Jung KW, 2017, CANCER RES TREAT, V49, P292, DOI 10.4143/crt.2017.118
   Kaptchuk TJ, 2002, ANN INTERN MED, V136, P374, DOI 10.7326/0003-4819-136-5-200203050-00010
   Leone C, 2011, FUTUR NEUROL, V6, P497, DOI 10.2217/FNL.11.23
   Lu ZX, 2017, J ALTERN COMPLEM MED, V23, P964, DOI 10.1089/acm.2017.0052
   Man P L, 1975, J Natl Med Assoc, V67, P115
   MILLER AB, 1981, CANCER, V47, P207, DOI 10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6
   Mols F, 2014, SUPPORT CARE CANCER, V22, P2261, DOI 10.1007/s00520-014-2255-7
   Ocean AJ, 2004, SUPPORT CARE CANCER, V12, P619, DOI 10.1007/s00520-004-0657-7
   Oh S., 2003, Clinical Electromyography: Nerve Conduction Studies
   Pachman DR, 2014, CURR TREAT OPTION ON, V15, P567, DOI 10.1007/s11864-014-0303-7
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Speck RM, 2013, J ONCOL PRACT, V9, pE234, DOI 10.1200/JOP.2012.000863
   Ventzel L, 2016, PAIN, V157, P560, DOI 10.1097/j.pain.0000000000000404
   Ware J.E., 2003, SF 36 HLTH SURVEY MA
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
   Wong Raimond, 2006, Acupunct Med, V24, P87
   Xiong ZF, 2016, WORLD J ACUPUNCT-MOX, V26, P20, DOI 10.1016/S1003-5257(17)30005-3
   Zhang SQ, 2017, J TRADIT CHIN MED, V37, P179
   Zhang Y, 2012, INT J MED SCI, V9, P521, DOI 10.7150/ijms.4503
NR 34
TC 21
Z9 25
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2018
VL 2018
AR 5367014
DI 10.1155/2018/5367014
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GZ3WW
UT WOS:000449319600001
PM 30420895
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Hsiao, IH
   Yen, CM
   Hsu, HC
   Liao, HY
   Lin, YW
AF Hsiao, I-Han
   Yen, Chia-Ming
   Hsu, Hsin-Cheng
   Liao, Hsien-Yin
   Lin, Yi-Wen
TI Chemogenetics Modulation of Electroacupuncture Analgesia in Mice Spared
   Nerve Injury-Induced Neuropathic Pain through TRPV1 Signaling Pathway
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE neuropathic pain; chemogenetics; TRPV1; pERK; electroacupuncture; SSC
ID SCIATIC-NERVE; INTERLEUKIN-1-BETA; DEFINITION; PATCH; MODEL
AB Neuropathic pain, which is initiated by a malfunction of the somatosensory cortex system, elicits inflammation and simultaneously activates glial cells that initiate neuroinflammation. Electroacupuncture (EA) has been shown to have therapeutic effects for neuropathic pain, although with uncertain mechanisms. We suggest that EA can reliably cure neuropathic disease through anti-inflammation and transient receptor potential V1 (TRPV1) signaling pathways from the peripheral to the central nervous system. To explore this, we used EA to treat the mice spared nerve injury (SNI) model and explore the underlying molecular mechanisms through novel chemogenetics techniques. Both mechanical and thermal pain were found in SNI mice at four weeks (mechanical: 3.23 +/- 0.29 g; thermal: 4.9 +/- 0.14 s). Mechanical hyperalgesia was partially attenuated by 2 Hz EA (mechanical: 4.05 +/- 0.19 g), and thermal hyperalgesia was fully reduced (thermal: 6.22 +/- 0.26 s) but not with sham EA (mechanical: 3.13 +/- 0.23 g; thermal: 4.58 +/- 0.37 s), suggesting EA's specificity. In addition, animals with Trpv1 deletion showed partial mechanical hyperalgesia and no significant induction of thermal hyperalgesia in neuropathic pain mice (mechanical: 4.43 +/- 0.26 g; thermal: 6.24 +/- 0.09 s). Moreover, we found increased levels of inflammatory factors such as interleukin-1 beta (IL1-beta), IL-3, IL-6, IL-12, IL-17, tumor necrosis factor alpha, and interferon gamma after SNI modeling, which decreased in the EA and Trpv1-/- groups rather than the sham group. Western blot and immunofluorescence analysis showed similar tendencies in the dorsal root ganglion, spinal cord dorsal horn, somatosensory cortex (SSC), and anterior cingulate cortex (ACC). In addition, a novel chemogenetics method was used to precisely inhibit SSC to ACC activity, which showed an analgesic effect through the TRPV1 pathway. In summary, our findings indicate a novel mechanism underlying neuropathic pain as a beneficial target for neuropathic pain.
C1 [Hsiao, I-Han] China Med Univ, Coll Med, Sch Med, Taichung 40402, Taiwan.
   [Hsiao, I-Han] China Med Univ Hosp, Dept Neurosurg, Taichung 40402, Taiwan.
   [Yen, Chia-Ming] Taichung Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Anesthesiol, Taichung 42743, Taiwan.
   [Yen, Chia-Ming] Tzu Chi Univ, Sch Postbaccalaureate Chinese Med, Hualien 97004, Taiwan.
   [Hsu, Hsin-Cheng; Liao, Hsien-Yin] China Med Univ, Coll Chinese Med, Sch Postbaccalaureate Chinese Med, Taichung 40402, Taiwan.
   [Hsu, Hsin-Cheng] China Med Univ, Dept Tradit Chinese Med, Hsinchu Hosp, Hsinchu 302, Taiwan.
   [Lin, Yi-Wen] China Med Univ, Grad Inst Acupuncture Sci, Coll Chinese Med, Taichung 40402, Taiwan.
   [Lin, Yi-Wen] China Med Univ, Chinese Med Res Ctr, Taichung 40402, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; Buddhist Tzu Chi General Hospital;
   Taichung Tzu Chi Hospital; Tzu Chi University; China Medical University
   Taiwan; China Medical University Taiwan; China Medical University
   Taiwan; China Medical University Taiwan
RP Liao, HY (corresponding author), China Med Univ, Coll Chinese Med, Sch Postbaccalaureate Chinese Med, Taichung 40402, Taiwan.; Lin, YW (corresponding author), China Med Univ, Grad Inst Acupuncture Sci, Coll Chinese Med, Taichung 40402, Taiwan.; Lin, YW (corresponding author), China Med Univ, Chinese Med Res Ctr, Taichung 40402, Taiwan.
EM coolfishing2002@gmail.com; terryyen1974@gmail.com;
   hchsu@mail.cmu.edu.tw; 017215@tool.caaumed.org.tw;
   yiwenlin@mail.cmu.edu.tw
RI Hsiao, I-Han/NOF-4604-2025
OI Hsiao, I-Han/0000-0002-6245-9023
FU NSTC
FX No Statement Available
CR Asgharzade S, 2020, CURR STEM CELL RES T, V15, P349, DOI 10.2174/1574888X15666200214112908
   Baranidharan G, 2013, THER ADV NEUROL DISO, V6, P287, DOI 10.1177/1756285613496862
   Baron R, 2010, LANCET NEUROL, V9, P807, DOI 10.1016/S1474-4422(10)70143-5
   Caterina MJ, 1997, NATURE, V389, P816, DOI 10.1038/39807
   Cichon J, 2018, BIO-PROTOCOL, V8, DOI [10.21769/BioProtoc.2777, 10.21769/bioprotoc.2777]
   Forouzanfar F, 2023, METAB BRAIN DIS, V38, P1421, DOI 10.1007/s11011-023-01190-x
   Goh S, 2018, AUST PRESCR, V41, P178, DOI 10.18773/austprescr.2018.069
   Goldman N, 2010, NAT NEUROSCI, V13, P883, DOI 10.1038/nn.2562
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   Hatch MN, 2018, J NEUROL SCI, V384, P75, DOI 10.1016/j.jns.2017.11.018
   Herrero JF, 2000, PROG NEUROBIOL, V61, P169, DOI 10.1016/S0301-0082(99)00051-9
   Hsiao IH, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/2242074
   Jones Virginia M, 2011, J Pain Palliat Care Pharmacother, V25, P32, DOI 10.3109/15360288.2010.547561
   Kiguchi N, 2010, PAIN, V149, P305, DOI 10.1016/j.pain.2010.02.025
   Leclerc E, 2009, BBA-MOL CELL RES, V1793, P993, DOI 10.1016/j.bbamcr.2008.11.016
   Llorca-Torralba M, 2019, BIOL PSYCHIAT, V85, P1021, DOI 10.1016/j.biopsych.2019.02.018
   Lotze MT, 2005, NAT REV IMMUNOL, V5, P331, DOI 10.1038/nri1594
   Malmberg AB, 1998, PAIN, V76, P215, DOI 10.1016/S0304-3959(98)00045-1
   Murnion BP, 2018, AUST PRESCR, V41, P60, DOI 10.18773/austprescr.2018.022
   Raja SN, 2020, PAIN, V161, P1976, DOI 10.1097/j.pain.0000000000001939
   Rakhshandeh H, 2021, METAB BRAIN DIS, V36, P1709, DOI 10.1007/s11011-021-00773-w
   Saloman JL, 2016, J NEUROSCI, V36, P10769, DOI 10.1523/JNEUROSCI.3480-15.2016
   Sarzi-Puttini P, 2020, NAT REV RHEUMATOL, V16, P645, DOI 10.1038/s41584-020-00506-w
   Sommer C, 2018, PAIN, V159, P595, DOI 10.1097/j.pain.0000000000001122
   Yam MF, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082164
   Yan B, 2023, PAIN MED, V24, P11, DOI 10.1093/pm/pnac115
   Yang C., 2023, bioRxiv, DOI [10.1523/JNEUROSCI.2303-22.2023, DOI 10.1523/JNEUROSCI.2303-22.2023]
   Yang S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20133130
   Yi MH, 2021, BRAIN BEHAV IMMUN, V92, P78, DOI 10.1016/j.bbi.2020.11.030
   Zanjani TM, 2006, EUR J PHARMACOL, V538, P66, DOI 10.1016/j.ejphar.2006.03.063
   Zelenka M, 2005, PAIN, V116, P257, DOI 10.1016/j.pain.2005.04.018
NR 31
TC 13
Z9 14
U1 3
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2024
VL 25
IS 3
AR 1771
DI 10.3390/ijms25031771
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HN5A7
UT WOS:001160184100001
PM 38339048
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Alræk, T
   Skjerve, H
   Sorensen, A
   Lie, SA
   Odegård, HP
   Lu, WD
   Mao, J
   Deng, G
   Lee, MS
   Birch, S
   Lamu, AN
   Kim, TH
   MacPherson, H
AF Alraek, Terje
   Skjerve, Hilde
   Sorensen, Anette
   Lie, S. A.
   Odegard, Hilde Presterud
   Lu, Weidong
   Mao, Jun
   Deng, G.
   Lee, Myeong Soo
   Birch, Stephen
   Lamu, Admassu Nadew
   Kim, Tae-hun
   MacPherson, Hugh
TI Acupuncture for fatigue in breast cancer survivors: a study protocol for
   a pragmatic, mixed method, randomised controlled trial
SO BMJ OPEN
LA English
DT Article
DE COMPLEMENTARY MEDICINE; Fatigue; Randomized Controlled Trial;
   Acupuncture; Clinical Trial
ID NORWEGIAN VERSION; SEVERITY
AB Introduction Fatigue is a common symptom observed in post-cancer treatment, yet its underlying mechanisms remain poorly understood. Acupuncture has been employed to alleviate cancer-related fatigue (CRF); however, its effectiveness in addressing associated comorbidities that may influence fatigue is also poorly understood. This study represents the first investigation to use acupuncture as an intervention for fatigue in breast cancer survivors within a Norwegian cohort. The study will employ questionnaires to evaluate various facets of fatigue. As a pragmatic trial, it statistically assesses its clinical relevance, documents adverse events and evaluates the cost-effectiveness of the acupuncture treatment.Methods and analysis This assessor-blinded, pragmatic, randomised, mixed method, controlled trial with two parallel arms aims to evaluate the effectiveness, safety and cost-effectiveness of acupuncture. It will recruit 250 participants presented with CRF for 6 months or longer. Patients will be randomly allocated either to acupuncture and usual care (n=125) or to usual care alone (n=125). Acupuncture treatments (12 in total) are to be given within 12 weeks. The statistician who will analyse the data will be blinded to group allocation. The primary outcome will be changes in CRF measured by the Chalder fatigue scale. Measurements will be taken 12 weeks and 6 months after randomisation. The secondary outcomes include patient-reported outcomes of pain, anxiety, depression, hot flashes, insomnia and sleepiness. Health-related quality of life and economic evaluation will also be conducted 12 weeks and 6 months after randomisation. Nested within this randomised controlled trial are two qualitative studies and one sub-study measuring biomarkers (C-reactive protein, interleukin (IL)-1, IL-6, tumour necrosis factor alpha (TNF-alpha) and aPL in addition to the current genotype genes TNF-308 and IL-6-174) from blood samples (n=80). Such biomarkers can potentially address changes in CRF.Ethics and dissemination Ethical approval of this study has been granted by the Regional Committees for Medical and Health Research Ethics (REC southeast ID number: 112285). Written informed consent will be obtained from all participants. The outcomes of the trial will be disseminated through peer-reviewed publications.Trial registration number NCT04418115.
C1 [Alraek, Terje] Artic Univ Norway, Dept Community Med, Dept Clin Med, Tromso, Norway.
   [Alraek, Terje; Skjerve, Hilde; Sorensen, Anette; Birch, Stephen] Kristiania Univ Coll, Oslo, Norway.
   [Lie, S. A.] Univ Bergen, Fac Med & Dent, Dept Dent, Bergen, Norway.
   [Odegard, Hilde Presterud] Diakonhjemmet Univ Coll & Hosp, Oslo, Norway.
   [Lu, Weidong] Harvard Med Sch, Dept Med Oncol, Boston, MA USA.
   [Mao, Jun; Deng, G.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, New York, NY USA.
   [Lee, Myeong Soo] Korea Inst Oriental Med, Daejeon, South Korea.
   [Lamu, Admassu Nadew] NORCE Norwegian Res Ctr AS, Bergen, Norway.
   [Kim, Tae-hun] Kyung Hee Univ, Korean Med Clin Trial Ctr, Korean Med Hosp, Seoul, South Korea.
   [MacPherson, Hugh] Univ York, Hlth Sci, York, England.
C3 UiT The Arctic University of Tromso; Kristiania University College;
   University of Bergen; Harvard University; Harvard Medical School;
   Memorial Sloan Kettering Cancer Center; Korea Institute of Oriental
   Medicine (KIOM); Norwegian Research Centre (NORCE); Kyung Hee
   University; Kyung Hee University Hospital; University of York - UK
RP Alræk, T (corresponding author), Artic Univ Norway, Dept Community Med, Dept Clin Med, Tromso, Norway.; Alræk, T (corresponding author), Kristiania Univ Coll, Oslo, Norway.
EM terje.alrak@uit.no; hilde.skjerve@kristiania.no;
   Anette.Sorensen@kristiania.no; Stein.Lie@uib.no;
   hilde.presterud.odegard@gmail.com; weidong_lu@dfci.harvard.edu;
   maoj@mskcc.org; dengg@mskcc.org; drmslee@gmail.com; sjbirch@gmail.com;
   alam@norceresearch.no; taehunkim@khu.ac.kr; hugh.macpherson@york.ac.uk
RI Lamu, Admassu N/HJB-0133-2022; Alræk, Terje/AAG-7001-2021; Lee, Myeong
   Soo/C-8147-2013; Kim, Tae-Hun/G-8728-2014
OI Skjerve, Hilde/0009-0006-9457-4946; Mao, Jun/0000-0001-9229-0380; Lee,
   Myeong Soo/0000-0001-6651-7641; 
FU Norwegian Cancer Society; Breast Cancer Society [207697- 2019];
   Kristiania University College
FX The study is funded by a grant from Pink Ribbon, a collaboration between
   the Norwegian Cancer Society and the Breast Cancer Society (Contract nr
   207697- 2019). The Biomarker study is funded by Kristiania University
   College. The funders have no influence in any part of the study nor in
   the dissemination of the results.
CR Annunziata MA, 2020, SUPPORT CARE CANCER, V28, P3921, DOI 10.1007/s00520-019-05244-8
   Beiske KK, 2009, SLEEP BREATH, V13, P65, DOI 10.1007/s11325-008-0202-x
   Bower JE, 2014, J CLIN ONCOL, V32, P1840, DOI 10.1200/JCO.2013.53.4495
   Chang HY, 2016, BREAST, V27, P116, DOI 10.1016/j.breast.2016.02.013
   de Boer AGEM, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007569.pub3
   Deng G, 2013, SUPPORT CARE CANCER, V21, P1735, DOI 10.1007/s00520-013-1720-z
   Devlin NJ, 2017, APPL HEALTH ECON HEA, V15, P127, DOI 10.1007/s40258-017-0310-5
   Fabi A, 2020, ANN ONCOL, V31, P713, DOI 10.1016/j.annonc.2020.02.016
   Filshie Jacqueline, 2006, Acupunct Med, V24, P172
   Hanevik K, 2014, CLIN INFECT DIS, V59, P1394, DOI 10.1093/cid/ciu629
   Hervik J, 2009, BREAST CANCER RES TR, V116, P311, DOI 10.1007/s10549-008-0210-3
   Jensen CE, 2021, APPL HEALTH ECON HEA, V19, P579, DOI 10.1007/s40258-021-00639-3
   Kiserud Cecilie E, 2014, Recent Results Cancer Res, V197, P103, DOI 10.1007/978-3-642-40187-9_8
   Koczwara B, 2023, SUPPORT CARE CANCER, V31, DOI 10.1007/s00520-023-07678-7
   Leiknes KA, 2016, Rapport 2016
   Lerdal A, 2005, SCAND J PUBLIC HEALT, V33, P123, DOI 10.1080/14034940410028406
   MacPherson H, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-209
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Malterud K, 2012, SCAND J PUBLIC HEALT, V40, P795, DOI 10.1177/1403494812465030
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Melchart D, 2004, ARCH INTERN MED, V164, P104, DOI 10.1001/archinte.164.1.104
   Minton O, 2008, BREAST CANCER RES TR, V112, P5, DOI 10.1007/s10549-007-9831-1
   Mock V, 2000, ONCOLOGY-NY, V14, P151
   Molassiotis A, 2013, ANN ONCOL, V24, P1645, DOI 10.1093/annonc/mdt034
   NoMa, 2020, Guidelines for the submission of documentation for single technology assessment (STA) of pharmaceuticals Oslo
   Orre IJ, 2011, J PSYCHOSOM RES, V71, P136, DOI 10.1016/j.jpsychores.2011.04.003
   Pallesen S, 2008, PERCEPT MOTOR SKILL, V107, P691, DOI 10.2466/PMS.107.3.691-706
   Paterson C, 2005, BMJ-BRIT MED J, V330, P1202, DOI 10.1136/bmj.330.7501.1202
   Timperi AW, 2013, PSYCHO-ONCOLOGY, V22, P1411, DOI 10.1002/pon.3157
   van Hout B, 2012, VALUE HEALTH, V15, P708, DOI 10.1016/j.jval.2012.02.008
   Vogelzang NJ, 1997, SEMIN HEMATOL, V34, P4
   Wang XS, 2014, CANCER-AM CANCER SOC, V120, P425, DOI 10.1002/cncr.28434
   White A, 2001, BRIT MED J, V323, P485, DOI 10.1136/bmj.323.7311.485
   Whitehead SJ, 2010, BRIT MED BULL, V96, P5, DOI 10.1093/bmb/ldq033
   Zhang Y, 2018, SUPPORT CARE CANCER, V26, P415, DOI 10.1007/s00520-017-3955-6
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 36
TC 0
Z9 0
U1 2
U2 10
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUL 30
PY 2024
VL 14
IS 7
AR e077514
DI 10.1136/bmjopen-2023-077514
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA F7L9L
UT WOS:001311601500001
PM 39079925
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Fink, J
   Burns, J
   Moreno, ACP
   Kram, JJF
   Armstrong, M
   Chopp, S
   Maul, SJ
   Conway, N
AF Fink, Jennifer
   Burns, John
   Perez Moreno, Ana Christina
   Kram, Jessica J. F.
   Armstrong, Melissa
   Chopp, Sara
   Maul, Scott J.
   Conway, Nancy
TI A Quality Brief of an Oncological Multisite Massage and Acupuncture
   Therapy Program to Improve Cancer-Related Outcomes
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE cancer-related symptoms; acupuncture treatment; massage treatment
ID INTEGRATIVE MEDICINE
AB Objectives:Cancer treatment can present its own physical and mental challenges resulting in symptoms such as fatigue, stress, pain, nausea, and vomiting. Aurora Health Care is a large health system with 19 cancer centers. Integrative therapies such as acupuncture and massage have demonstrated success in reducing cancer-related symptoms and side effects to conventional cancer treatment and improving patient outcomes. In 2018, 15 of the 19 Aurora Cancer Clinics embedded a replicable Integrative Cancer Care closed model to provide adjuvant therapies for the best patient outcomes. This quality improvement study aimed to explore if the replicable integrative care model could demonstrate consistent outcomes for massage and acupuncture therapies aimed at symptom reduction across multiple oncology clinics. Design:Aurora Cancer Care and Aurora Integrative Medicine designed a reproducible integrative therapy service model to be embedded into the Aurora Cancer Centers. Integrative therapies within the cancer centers allow patients easy access to care before, during, or after their cancer treatment. In 2018, 15 of the 19 cancer clinics had integrative therapies available to patients with cancer. This model required unified operations, onboarding, training, competency, and clinical oversight to achieve consistent processes for consistent outcomes. Furthermore, these innovative models prioritized the following: patient access (easy and affordable); service delivery (consistent and operationalized); clinical outcomes (effective and meaningful); and caliber of clinician (competent and confident). Aurora Health Care employs massage therapists (Mts) and acupuncturists (Ats). This employment model allows for standards and program model adherence. To achieve competent and confident clinician's, MT or AT must complete a cancer treatment-focused competency training program relative to their respective profession and adherence to practice standards outlined. The training program is built on evidence-based practice, observation, direct demonstration, return demonstration, mentorship, and ongoing quality review by clinical leaders. Aurora's Integrative Cancer Care closed model of care is accessible to patients through philanthropic funds secured to underwrite the free service of MT provided during infusion treatments. Funds also provided three free AT sessions. Ongoing acupuncture therapies were provided at a low-cost group acupuncture fee at $25.00 per treatment. Acupuncture is available in group format and provided either before or after chemotherapy treatment. The free services were intended to introduce the concept of integrative therapies as a viable adjuvant option with conventional cancer care. As this model incorporates a mix of philanthropic funding and low-cost fees to offset the cost of the therapy provider, it is referred to as a "closed model" or accessible only to those patients under the care of an Aurora Cancer specialist. In 2018, 15 Aurora Cancer Clinics offered massage and 11 Aurora Cancer Clinics offered acupuncture. Patients who self-selected integrative therapies via system-employed Mts and Ats were surveyed pre/post acupuncture and MT treatments using a visual analog scale about their perceived levels of pain, stress, nausea, and neuropathy. The staff integrative clinicians collected data from patients, and post-treatment data were compiled by the Department of Integrative Medicine. Settings/Location:Aurora Cancer Centers are embedded within Aurora hospitals or free-standing clinics located throughout Wisconsin.
   In 2018, 15 cancer clinic locations embedded Mts, and 11 cancer clinic locations embedded Ats. Subjects:Oncology patients. Interventions:Clinical competencies were developed and applied to address indications, contraindications, and oncology-specific procedures to ensure that consistent quality of therapies was provided across sites. In 2018, Ats delivered 4367 Ats across 11 locations and Mts delivered 4197 Mts across 15 locations. During this study, the number of treatments provided was tracked versus episodic care. Outcome Measures:Pre/post AT and MT pain, stress, nausea, and neuropathy scores were recorded (0 [least] to 10 [worst]) and compared using pairedt-tests. Results:Pre/post AT scores for pain, neuropathy, stress, and nausea were all significantly different (p < 0.001). For AT, there was a reported decrease in pain, stress, and neuropathy of 61.7%, 68.8%, and 47.9%, respectively. Pre/post MT scores for pain, neuropathy, nausea, and stress were also significantly different (p < 0.001). MT was greater at reducing stress and pain, 42.5% and 34.4%, respectively. Conclusions:Across 15 cancer clinics, both AT and MT treatments consistently and significantly reduced cancer-related side effects. These findings highlight the value of conducting a larger randomized-controlled trial to further assess the impact of Oncological Multisite Massage and Acupuncture Therapy on cancer-related symptoms across multiple oncologic clinics.
C1 [Fink, Jennifer; Chopp, Sara] Univ Wisconsin, Dept Hlth Informat & Adm, 2025 East Newport Ave, Milwaukee, WI 53211 USA.
   [Burns, John; Armstrong, Melissa; Conway, Nancy] Aurora Sinai Med Ctr, Aurora Hlth Care, Dept Integrat Med, Milwaukee, WI USA.
   [Perez Moreno, Ana Christina] Aurora Hlth Care, Aurora Res Inst, Milwaukee, WI USA.
   [Kram, Jessica J. F.] Aurora Sinai Med Ctr, Aurora Hlth Care, Aurora UW Med Grp, Milwaukee, WI USA.
   [Kram, Jessica J. F.] Aurora Sinai Med Ctr, Aurora Hlth Care, Ctr Urban Populat Hlth, Milwaukee, WI USA.
   [Maul, Scott J.] Aurora Hlth Care, Dept Oncol, Milwaukee, WI USA.
C3 University of Wisconsin System; University of Wisconsin Milwaukee;
   University of Wisconsin System; University of Wisconsin Milwaukee
RP Fink, J (corresponding author), Univ Wisconsin, Dept Hlth Informat & Adm, 2025 East Newport Ave, Milwaukee, WI 53211 USA.
EM jtfink@uwm.edu
OI Kram, Jessica/0000-0001-9831-7353
CR Armstrong K, 2018, SUPPORT CARE CANCER, V26, P2267, DOI 10.1007/s00520-017-4007-y
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   Deng G, 2017, J NATL CANC I MONOGR, V2017
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Kedar A, 2012, PROG PALLIAT CARE, V20, P284, DOI 10.1179/1743291X12Y.0000000034
   Lu WD, 2013, CURR PAIN HEADACHE R, V17, DOI 10.1007/s11916-013-0321-3
   Pearce A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184360
   Schuster L, 2018, JNP-J NURSE PRACT, V14, P276, DOI 10.1016/j.nurpra.2017.11.015
   Siegel P, 2015, EUR J INTEGR MED, V7, P23, DOI 10.1016/j.eujim.2014.11.004
   Stone JAM, 2010, CURR TREAT OPTION ON, V11, P118, DOI 10.1007/s11864-010-0128-y
NR 10
TC 14
Z9 15
U1 1
U2 16
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD SEP 1
PY 2020
VL 26
IS 9
BP 820
EP 824
DI 10.1089/acm.2019.0371
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA NN8AD
UT WOS:000569008100013
PM 32924553
DA 2026-01-16
ER

PT J
AU Ling, WH
   Yang, CX
   Ho, MH
   Lee, JJ
AF Ling, Weihong
   Yang, Chenxi
   Ho, Mu-Hsing
   Lee, Jung Jae
TI Effectiveness of Acupressure on Sleep Quality Among Inpatients: A
   Systematic Review and Meta-Analysis
SO NURSING & HEALTH SCIENCES
LA English
DT Review
DE acupressure; adults; inpatients; meta-analysis; sleep quality;
   systematic review
ID AURICULAR ACUPRESSURE; CHINESE MEDICINE; CANCER; DIAGNOSIS; INSOMNIA;
   THERAPY; PATIENT
AB Sleep quality in adult inpatients is frequently and severely disturbed by various factors such as noise, pain, and unfamiliar surroundings, which can impair disease recovery. Acupressure is widely used to improve sleep quality in hospitalized patients, but its overall effectiveness is unclear. This meta-analysis aims to analyze the efficacy of acupressure therapy on sleep quality and sleep parameters in adult inpatients. Eight electronic databases were searched for randomized controlled trials published before April 2024. Two researchers independently screened, assessed, and extracted data from the included studies. A total of 41 studies involving 3680 subjects were included. The meta-analysis showed a significant difference between the acupressure and control groups in sleep quality (SMD = -1.58, 95% CI [-1.85, -1.31]), total sleep time (SMD = 1.12, 95% CI [0.40, 1.83]), sleep efficiency (SMD = 0.90, 95% CI [0.29, 1.52]), sleep onset latency (SMD = -0.73, 95% CI [-1.14, -0.33]), and wake after sleep onset (SMD = -1.32, 95% CI [-2.55, -0.09]). The meta-regression results suggested that the number of sessions daily and the duration of each session were significant factors influencing heterogeneity. Acupressure is an effective intervention to improve sleep quality and sleep parameters in inpatients.
C1 [Ling, Weihong; Yang, Chenxi; Ho, Mu-Hsing; Lee, Jung Jae] Univ Hong Kong, LKS Fac Med, Sch Nursing, Hong Kong, Peoples R China.
   [Ling, Weihong] Chongqing Univ, Chongqing Gen Hosp, Dept Gen Surg, Chongqing, Peoples R China.
   [Lee, Jung Jae] George Inst Global Hlth, Sydney, Australia.
C3 University of Hong Kong; Chongqing University; George Institute for
   Global Health
RP Lee, JJ (corresponding author), Univ Hong Kong, LKS Fac Med, Sch Nursing, Hong Kong, Peoples R China.; Lee, JJ (corresponding author), George Inst Global Hlth, Sydney, Australia.
EM leejay@hku.hk
RI ; Ho, Mu-Hsing/Y-9105-2019
OI YANG, CHENXI/0009-0007-0410-587X; Ho, Mu-Hsing/0000-0002-9443-4082; Lee,
   Jay Jung Jae/0000-0001-9704-2116
CR [Anonymous], 1993, Standard Acupuncture Nomenclature, V2nd
   [Anonymous], 2012, Chinese Journal of Modern Nursing, DOI DOI 10.3760/CMA.J.ISSN.1674-2907.2012.33.009
   Asgari MR, 2020, COMPLEMENT THER CLIN, V38, DOI 10.1016/j.ctcp.2019.101066
   Ashghab A, 2024, Intensive Care Research, V4, P55, DOI [10.1007/s44231-024-00056-9, 10.1007/s44231-024-00056-9, DOI 10.1007/S44231-024-00056-9]
   Bagheri-Nesami Masoumeh, 2015, J Tradit Complement Med, V5, P241, DOI [10.1016/j.jtcme.2014.11.005, 10.1016/j.jtcme.2014.11.005]
   Bang YY, 2020, APPL NURS RES, V53, DOI 10.1016/j.apnr.2020.151269
   Bellon F, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-26412-7
   Bellon F, 2021, INT J NURS STUD, V115, DOI 10.1016/j.ijnurstu.2020.103855
   Beswick AD, 2023, SLEEP MED, V107, P243, DOI 10.1016/j.sleep.2023.05.004
   Birling Y., 2021, Chinese Herbal Medicine for Insomnia: Evidence and Experience.
   Cheisson G, 2018, ANAESTH CRIT CARE PA, V37, pS5, DOI 10.1016/j.accpm.2018.02.019
   Chen B., 2021, New Mom and New Born, V32, P181
   Chen H, 2022, CHIN J INTEGR MED, V28, P1096, DOI 10.1007/s11655-022-3581-0
   Chen L., 2014, China Modern Doctor, V52, P128
   Cheng HL, 2023, J PAIN SYMPTOM MANAG, V66, pE109, DOI 10.1016/j.jpainsymman.2023.03.002
   Cho HJ, 2022, J GEN INTERN MED, V37, P2454, DOI 10.1007/s11606-021-07269-4
   D'souza OL, 2019, INDIAN J MED SPEC, V10, P201, DOI 10.4103/INJMS.INJMS_17_19
   Dincer B, 2022, EXPLORE-NY, V18, P635, DOI 10.1016/j.explore.2021.11.010
   Eckstein M, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.555058
   Foley HM, 2019, COMPLEMENT THER MED, V42, P65, DOI 10.1016/j.ctim.2018.11.003
   Fu M., 2021, Journal of Guangzhou University of Traditional Chinese Medicine, V38, P880, DOI [10.13359/j.cnki.gzxbtcm.2021.05.004, DOI 10.13359/J.CNKI.GZXBTCM.2021.05.004]
   Garbarino S, 2021, COMMUN BIOL, V4, DOI 10.1038/s42003-021-02825-4
   Godson DR, 2019, J ACUPUNCT MERIDIAN, V12, P52, DOI 10.1016/j.jams.2018.10.009
   Gonzalez MC, 2017, J CACHEXIA SARCOPENI, V8, P187, DOI 10.1002/jcsm.12159
   Guo KX, 2024, FRONT NEUROSCI-SWITZ, V18, DOI 10.3389/fnins.2024.1426618
   Haiyan Q., 2016, Western J Traditional Chin Med, V29, P112, DOI DOI 10.3969/J.ISSN.1004-6852.2016.04.039
   Han L., 2021, Zhonghua Yangsheng Baojian, V39, P58
   Han X., 2019, Maternal and Child Health Care of China, V34, P2640, DOI [10.7620/zgfybj.j.issn.1001-4411.2019.11.71, DOI 10.7620/ZGFYBJ.J.ISSN.1001-4411.2019.11.71]
   Hendy P, 2012, CLIN MED, V12, P320, DOI 10.7861/clinmedicine.12-4-320
   Herzig SJ, 2021, SLEEP, V44, DOI 10.1093/sleep/zsab064
   Higgins J.P.T., 2022, Cochrane
   Hillman DR, 2021, ANESTH ANALG, V132, P1314, DOI 10.1213/ANE.0000000000005323
   Hou J., 2017, China Modern Medicine, V24, P111
   Hsieh SH, 2021, CANCER NURS, V44, pE578, DOI 10.1097/NCC.0000000000000997
   Hu Hiroe, 2019, Glob Adv Health Med, V8, p2164956119880143, DOI [10.1177/2164956119880143, 10.1177/2164956119880143]
   Huang F., 2014, Liaoning Journal of Traditional Chinese Medicine, V41, P1726, DOI [10.13192/j.issn.1000-1719.2014.08.072, DOI 10.13192/J.ISSN.1000-1719.2014.08.072]
   Huang X, 2021, DRUG DES DEV THER, V15, P2161, DOI 10.2147/DDDT.S304162
   Hutsalenko OO, 2022, ACTA BALNEOL, V64, P342, DOI 10.36740/ABAL202204112
   Jain A, 2019, International Journal of Chemical Studies, V7, P323
   Jaiswal SJ, 2017, J HOSP MED, V12, P798, DOI 10.12788/jhm.2826
   Jiang-Siebert Q, 2025, INT NURS REV, V72, DOI 10.1111/inr.12989
   Jones LA, 2020, INT J BIOCHEM CELL B, V125, DOI 10.1016/j.biocel.2020.105776
   Jun JH, 2021, INTENS CRIT CARE NUR, V67, DOI 10.1016/j.iccn.2021.103124
   Kanji S, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-012108
   Kulpatcharapong Santi, 2020, Sleep Disord, V2020, P8518396, DOI [10.1155/2020/8518396, 10.1155/2020/8518396]
   Lee BH, 2021, P NATL ACAD SCI USA, V118, DOI [10.1073/pnas.2113852118j1of9, 10.1073/pnas.2113852118]
   Lee SN, 2021, COMPLEMENT THER CLIN, V44, DOI 10.1016/j.ctcp.2021.101447
   Li CL, 2023, ALTERN THER HEALTH M, V29, P186
   [李静 Li Jing], 2021, [世界科学技术：中医药现代化, Modernization of Traditional Chinese Medicine and Materia Medica--World Science and Technology], V23, P2086
   Li SY, 2021, NAT SCI SLEEP, V13, P375, DOI 10.2147/NSS.S300803
   Li X., 2019, Chinese and Foreign Medical Research, V17, P97, DOI [10.14033/j.cnki.cfmr.2019.23.038, DOI 10.14033/J.CNKI.CFMR.2019.23.038]
   Li Zhi-Qiang, 2024, Heliyon, V10, pe38675, DOI [10.1016/j.heliyon.2024.e38675, 10.1016/j.heliyon.2024.e38675]
   Liang Y., 2021, China's Naturopathy, V29, P59, DOI [10.19621/j.cnki.11-3555/r.2021.0224, DOI 10.19621/J.CNKI.11-3555/R.2021.0224]
   Lin CH, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/1399258
   Lin L., 2023, World Journal of Sleep Medicine, V10, P732, DOI [10.3969/j.issn.2095-7130.2023.04.011, DOI 10.3969/J.ISSN.2095-7130.2023.04.011]
   Lin L, 2020, PATIENT PREFER ADHER, V14, P1275, DOI 10.2147/PPA.S261466
   Lin L, 2021, BMJ SUPPORT PALLIAT, V11, P32, DOI 10.1136/bmjspcare-2019-001937
   Lindquist R., 2022, Complementary Therapies in Nursing: Promoting Integrative Care, DOI [10.4037/ccn2014754, DOI 10.4037/CCN2014754]
   Liu MM, 2021, PAIN MANAG NURS, V22, P268, DOI 10.1016/j.pmn.2020.07.007
   Liu S. Q., 2020, WORLD J SLEEP MED, V7, P1327, DOI DOI 10.3969/J.ISSN.2095-7130.2020.08.011
   Liu Y., 2021, Chinese and Foreign Medical Research, V19, P169, DOI [10.14033/j.cnki.cfmr.2021.06.065, DOI 10.14033/J.CNKI.CFMR.2021.06.065]
   Liu Y. H., 2016, CHINESE NURSING RES, V30, P4573, DOI [10.3969/j.issn.1009-6493.2016.36.033, DOI 10.3969/J.ISSN.1009-6493.2016.36.033]
   Liu Y, 2024, INT J CLIN PRACT, V2024, DOI 10.1155/2024/6763996
   Lozano F., 2014, Acupuncture for Pain Management, P13, DOI [10.1007/978-1-4614-5275-12, DOI 10.1007/978-1-4614-5275-12]
   Lu HB, 2022, HOLIST NURS PRACT, V36, pE27, DOI 10.1097/HNP.0000000000000532
   Lu MJ, 2013, NURS RES, V62, P130, DOI 10.1097/NNR.0b013e3182781524
   Luo T., 2016, Journal of External Therapy of Traditional Chinese Medicine, V25, P6
   Matos LC, 2021, HEALTHCARE-BASEL, V9, DOI 10.3390/healthcare9030257
   Mehta Piyush, 2017, J Tradit Complement Med, V7, P251, DOI [10.1016/j.jtcme.2016.06.004, 10.1016/j.jtcme.2016.06.004]
   Meng H., 2017, Journal of Clinical Psychosomatic Diseases, V23, P100, DOI [10.3969/j.issn.1672-187X.2017.03.034-0100-03, DOI 10.3969/J.ISSN.1672-187X.2017.03.034-0100-03]
   Montakab HD, 2014, MED ACUPUNCT, V26, P315, DOI 10.1089/acu.2014.1064
   Morin CM, 2021, SLEEP MED, V81, P124, DOI 10.1016/j.sleep.2021.01.023
   Morse AM, 2019, CLOCKS SLEEP, V1, P151, DOI 10.3390/clockssleep1010014
   Moses MW, 2019, LANCET PUBLIC HEALTH, V4, pE49, DOI 10.1016/S2468-2667(18)30213-5
   National Technical Committee on Acupuncture, 2008, Nomenclature and Location of Auricular Points. (GB/T 137342008).
   Nelson KL, 2022, NURS FORUM, V57, P144, DOI 10.1111/nuf.12659
   Nerbass F. B., 2015, organizadores. PROFISIO Programa de Atualizao em Fisioterapia em Terapia Intensiva Adulto. Ciclo, P99
   Ni M., 2016, Modern Nurse, V12, P104
   Nielsen A, 2020, PAIN MED, V21, P1276, DOI 10.1093/pm/pnz379
   Nys LD, 2022, PSYCHONEUROENDOCRINO, V143, DOI 10.1016/j.psyneuen.2022.105843
   Ohki S, 2022, CHEM PHARM BULL, V70, P375, DOI 10.1248/cpb.c21-00982
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n160, 10.1136/bmj.n71, 10.1038/nchembio.2180, 10.1186/s40900-023-00424-7, 10.3390/jpm13020373]
   Ramar K, 2021, J CLIN SLEEP MED, V17, P2115, DOI 10.5664/jcsm.9476
   Relton C, 2013, COMPLEMENT THER MED, V21, P121, DOI 10.1016/j.ctim.2012.12.011
   Salajegheh Z, 2024, BMC COMPLEMENT MED, V24, DOI 10.1186/s12906-023-04292-2
   Sato-Suzuki I, 2019, AUTON NEUROSCI-BASIC, V220, DOI 10.1016/j.autneu.2019.102557
   Schünemann HJ, 2020, J CLIN EPIDEMIOL, V122, P142, DOI 10.1016/j.jclinepi.2019.12.021
   Sha Y. S., 2016, TIANJIN J NURSING, V24, P496, DOI DOI 10.3969/J.ISSN.1006-9143.2016.06.010
   Sun M., 2022, Reflexology and Rehabilitation Medicine, V3, P51
   Sun S., 2021, Journal of New Chinese Medicine, V53, P186, DOI [10.13457/j.cnki.jncm.2021.16.048, DOI 10.13457/J.CNKI.JNCM.2021.16.048]
   Tan JY, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/506758
   Tan JY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132989
   Tian M, 2021, FRONT CHEM, V9, DOI 10.3389/fchem.2021.666280
   Vedantam D, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.26714
   Vin-Raviv N, 2018, SUPPORT CARE CANCER, V26, P1833, DOI 10.1007/s00520-017-4012-1
   Waits A, 2018, SLEEP MED REV, V37, P24, DOI 10.1016/j.smrv.2016.12.004
   Wang J, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000033213
   Wang XT, 2020, COMPLEMENT THER CLIN, V39, DOI 10.1016/j.ctcp.2020.101151
   Wang Y., 2024, Textbook of Traditional Chinese Medicine: Volume 1: Introduction, Examination, Etiologies and Pathogenesis and Differentiation of Syndromes, P79
   Wang Y., 2023, Smart Health, V9, P158, DOI [10.19335/j.cnki.2096-1219.2023.14.039, DOI 10.19335/J.CNKI.2096-1219.2023.14.039]
   Wei Q., 2014, Chinese Journal of Ethnomedicine and Ethnopharmacy, V14, P42
   Wei Y., 2021, Journal of Changchun University of Chinese Medicine, V37, P1134, DOI [10.13463/j.cnki.cczyy.2021.05.049, DOI 10.13463/J.CNKI.CCZYY.2021.05.049]
   White B, 2023, J PHARM PRACT, V36, P126, DOI 10.1177/08971900211017857
   Wu J., 2017, Shaanxi J Trad Chin Med, V38, P103, DOI 10.3969/j.issn.1000-7369.2017.01.051
   Wu L., 2015, Chinese Rural Health Service Administration, V35, P662
   Xiao A., 2015, Journal of External Therapy of Traditional Chinese Medicine, V24, P15, DOI 10.3969/j.issn.1006-978X.2015.02.007
   Xie WX, 2023, INT J NURS STUD, V145, DOI 10.1016/j.ijnurstu.2023.104531
   Xie ZZ, 2017, NEUROL RES, V39, P559, DOI 10.1080/01616412.2017.1315864
   2023, International Journal of World Medicine, V4, DOI [10.38007/ijwm.2023.040209, 10.38007/IJWM.2023.040209, DOI 10.38007/IJWM.2023.040209]
   Yang X., 2021, Journal of Medical Theory and Practice, V34, P1583, DOI [10.19381/j.issn.1001-7585.2021.09.070, DOI 10.19381/J.ISSN.1001-7585.2021.09.070]
   Yang Y., 2019, Medical Forum, V23, P771, DOI [10.19435/j.1672-1721.2019.06.016, DOI 10.19435/J.1672-1721.2019.06.016]
   Yao J., 2023, Maternal and Child Health Care of China, V38, P3126, DOI [10.19829/j.zgfybj.issn.10014411.2023.16.046, DOI 10.19829/J.ZGFYBJ.ISSN.10014411.2023.16.046]
   Ye Yu-Fei, 2019, Zhongguo Zhen Jiu, V39, P605, DOI 10.13703/j.0255-2930.2019.06.010
   Yeh CH, 2023, PAIN MANAG NURS, V24, P19, DOI 10.1016/j.pmn.2022.11.004
   Yin R., 2014, Shanghai Journal of Acupuncture and Moxibustion, V8, P710, DOI [10.13460/j.issn.1005-0957.2014.08.0710, DOI 10.13460/J.ISSN.1005-0957.2014.08.0710]
   Yoon DE, 2022, AM J CHINESE MED, V50, P653, DOI 10.1142/S0192415X22500264
   Younis MB, 2018, CRIT CARE NURS Q, V41, P170, DOI 10.1097/CNQ.0000000000000196
   Zhang CS, 2014, J ALTERN COMPLEM MED, V20, P147, DOI 10.1089/acm.2013.0238
   Zhang Z., 2023, Henan Medical Research, V32, P4363, DOI [10.3969/j.issn.1004-437x.2023.23.034, DOI 10.3969/J.ISSN.1004-437X.2023.23.034]
   Zhao L, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/543943
   Zhou Z., 2023, Journal of Medical Theory and Practice, V36, P343, DOI [10.19381/j.issn.1001-7585.2023.02.065, DOI 10.19381/J.ISSN.1001-7585.2023.02.065]
   Zhu Y., 2020, China Modern Doctor, V58, P173
NR 122
TC 0
Z9 1
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1441-0745
EI 1442-2018
J9 NURS HEALTH SCI
JI Nurs. Health Sci.
PD MAR 6
PY 2025
VL 27
IS 1
AR e70075
DI 10.1111/nhs.70075
PG 22
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA Z4Q1U
UT WOS:001438764300001
PM 40049603
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Teoh, AYB
   Chong, CCN
   Leung, WW
   Chan, SKC
   Tse, YK
   Ng, EKW
   Lai, PBS
   Wu, JCY
   Lau, JYW
AF Teoh, Anthony Yuen Bun
   Chong, Charing Ching Ning
   Leung, Wing Wa
   Chan, Simon Kin Cheong
   Tse, Yee Kit
   Ng, Enders Kwok Wai
   Lai, Paul Bo San
   Wu, Justin Che Yuen
   Lau, James Yun Wong
TI Electroacupuncture-reduced sedative and analgesic requirements for
   diagnostic EUS: a prospective, randomized, double-blinded,
   sham-controlled study
SO GASTROINTESTINAL ENDOSCOPY
LA English
DT Article
ID CONTROLLED-TRIAL; GI ENDOSCOPY; ACUPUNCTURE; DISORDERS; CANCER;
   GASTROSCOPY; COLONOSCOPY
AB Background and Aims: The role of electroacupuncture (EA) in reducing sedative and analgesic requirements during EUS is uncertain. The aim of this study was to investigate the efficacy of EA in reducing procedure-related pain and discomfort during EUS.
   Methods: This was a double-blinded randomized controlled study conducted between March 2014 and July 2016. Consecutive patients who were scheduled for diagnostic EUS were recruited and randomized to receive EA or sham-electroacupuncture (SA). The primary outcome was the dosage of propofol used. Other outcome measurements included pain scores, anxiety scores, satisfaction scores, patients' willingness to repeat the procedure, total procedure time, and adverse events.
   Results: A total of 128 patients were recruited to the study. The patients who received EA had significantly fewer requirements for patient-controlled sedation and analgesia (PCA). The median (interquartile range) number of demands for PCA (2 [1-5] vs 16.5 [8.5-33.8]; P < .001), the number of successful demands (2 [1-4] vs 9 [5.3-13]; P < .001), and the total dose of propofol (0.15 [0.08-0.34] vs 0.77 [0.38-1.09]; P < .001) and alfentanil (0.38 [0.20-0.86] vs 1.92 [0.94-2.72]; P < .001) were all significantly less. Patients who received EA also had significantly lower procedural pain scores and anxiety scores (P < .001), and higher satisfaction scores (P < .001), and they were more willing to repeat the procedure (P < .001). Being in the SA group and the procedure time were significant predictors of increased PCA demands (P < .001 and P = .009, respectively).
   Conclusions: In conclusion, the use of EA reduced sedative and analgesia demands, improved patient experience, and was associated with a low risk of adverse events during diagnostic EUS.
C1 [Teoh, Anthony Yuen Bun; Chong, Charing Ching Ning; Leung, Wing Wa; Ng, Enders Kwok Wai; Lai, Paul Bo San; Lau, James Yun Wong] Chinese Univ Hong Kong, Dept Surg, Shatin, Hong Kong, Peoples R China.
   [Chan, Simon Kin Cheong; Lau, James Yun Wong] Chinese Univ Hong Kong, Dept Anaesthesia & Intens Care, Shatin, Hong Kong, Peoples R China.
   [Tse, Yee Kit; Ng, Enders Kwok Wai; Lai, Paul Bo San; Wu, Justin Che Yuen] Chinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China.
   [Wu, Justin Che Yuen] Chinese Univ Hong Kong, Inst Integrat Med, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong; Prince of Wales Hospital Hong Kong;
   Chinese University of Hong Kong
RP Teoh, AYB (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R China.
EM anthonyteoh@surgery.cuhk.edu.hk
RI Teoh, Anthony/L-4796-2016; Chong, Charing/M-3455-2018; Wu,
   Justin/N-6916-2015; Ng, Enders Kwok-wai/E-8276-2016; Lai,
   Paul/K-8556-2015; Lau, James/O-2612-2016
OI Chong, Charing/0000-0002-8425-8767; Ng, Enders
   Kwok-wai/0000-0001-7219-5810; 
FU Health and Medical Research Fund, Hong Kong
FX This study was supported by the Health and Medical Research Fund, Hong
   Kong (Dr Teoh). All other authors disclosed no financial relationships
   relevant to this publication.
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   CAHN AM, 1978, LANCET, V1, P182
   Chou PC, 2011, J ALTERN COMPLEM MED, V17, P199, DOI 10.1089/acm.2010.0192
   Diehl DL, 1999, J ALTERN COMPLEM MED, V5, P27, DOI 10.1089/acm.1999.5.27
   Dill S G, 1992, Probl Vet Med, V4, P144
   DIMAGNO EP, 1980, LANCET, V1, P629
   Fanti L, 2003, AM J GASTROENTEROL, V98, P312, DOI 10.1016/S0002-9270(02)05899-9
   Hammerschlag R, 2011, CLIN ACUPUNCTURE SCI, P211
   Lee H, 2004, GASTROINTEST ENDOSC, V60, P784, DOI 10.1016/S0016-5107(04)02030-9
   Leung WW, 2011, J GASTROINTEST SURG, V15, P660, DOI 10.1007/s11605-011-1446-5
   Lichtenstein DR, 2008, GASTROINTEST ENDOSC, V68, P205, DOI 10.1016/j.gie.2008.06.002
   Longstreth GF, 2006, GASTROENTEROLOGY, V130, P1480, DOI 10.1053/j.gastro.2005.11.061
   Mao JJ, 2015, J CLIN ONCOL, V33, P3615, DOI 10.1200/JCO.2015.60.9412
   Mayor D, 2013, ACUPUNCT MED, V31, P409, DOI 10.1136/acupmed-2013-010324
   McKeon C, 2015, ACUPUNCT MED, V33, P277, DOI 10.1136/acupmed-2015-010781
   Melchart D, 2002, J ALTERN COMPLEM MED, V8, P265, DOI 10.1089/10755530260127952
   Ng SSM, 2013, GASTROENTEROLOGY, V144, P307, DOI 10.1053/j.gastro.2012.10.050
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Roboubi B, 2006, REGION ANESTH PAIN M, V31, P91, DOI 10.1016/j.rapm.2005.09.006
   Shen YH, 2015, CANCER-AM CANCER SOC, V121, P84, DOI 10.1002/cncr.28973
   Stellon A, 1999, ACUPUNCT MED, V17, P2
   WANG HH, 1992, AM J ACUPUNCTURE, V20, P217
   Wang HH, 1997, AM J CHINESE MED, V25, P13, DOI 10.1142/S0192415X97000044
   Wang WM, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005735
   Yin JY, 2010, AUTON NEUROSCI-BASIC, V157, P31, DOI 10.1016/j.autneu.2010.03.007
NR 25
TC 13
Z9 15
U1 1
U2 18
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0016-5107
EI 1097-6779
J9 GASTROINTEST ENDOSC
JI Gastrointest. Endosc.
PD FEB
PY 2018
VL 87
IS 2
BP 476
EP 485
DI 10.1016/j.gie.2017.07.029
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA FV2LO
UT WOS:000424398500022
PM 28750840
DA 2026-01-16
ER

PT J
AU Kang, SY
   Bang, SK
   Kwon, OS
   Seo, SY
   Choi, KH
   Cho, SJ
   Yoo, HS
   Lee, JS
   Kim, HW
   Ryu, Y
AF Kang, Suk-Yun
   Bang, Se Kyun
   Kwon, O. Sang
   Seo, Su-Yeon
   Choi, Kwang-Ho
   Cho, Seong Jin
   Yoo, Hwa Seung
   Lee, Jin Sun
   Kim, Hyun-Woo
   Ryu, Yeonhee
TI Treatment of electrical wrist stimulation reduces chemotherapy-induced
   neuropathy and ultrasound vocalization via modulation of spinal NR2B
   phosphorylation
SO BRAIN RESEARCH BULLETIN
LA English
DT Article
DE Chemotherapy; Docetaxel; Analgesia; Electrical stimulation; Ultrasound
ID INDUCED PERIPHERAL NEUROPATHY; MECHANICAL ALLODYNIA; NERVE-STIMULATION;
   LABORATORY RATS; D-SERINE; PAIN; ACUPUNCTURE; ELECTROACUPUNCTURE;
   CANCER; NEUROTOXICITY
AB Docetaxel, a chemotherapeutic agent used to treat breast cancer, produces a robust painful neuropathy that is aggravated by mechanical and thermal stimuli. This study was undertaken to investigate the analgesic effects of electrical stimulation on docetaxel-induced neuropathic pain in mice and to identify associated changes in ultrasound vocalizations. Peripheral neuropathy was induced with intraperitoneally injected docetaxel (5 mg/kg) on 3 times every 2 days in male ICR mice. Electrical wrist stimulation was administered and pain behavior signs were evaluated by von Frey filaments and thermal stimulation on the hind paw. Ultrasound vocalizations were measured using ultrasound microphones, after electrical stimulation. After mice developed docetaxel-induced neuropathic pain behavior, an electrical stimulation temporarily attenuated mechanical allodynia and thermal hyperalgesia. In formalin and NMDA test, pain-induced mice showed increases in 10-30 kHz ultrasound vocalizations, but not in 30-50 and 50-80 kHz vocalizations. Treatment with docetaxel selectively increased 10-30 kHz ultrasound vocalizations, whereas electrical stimulation caused a meaningful decrease. Moreover, electrical stimulation suppressed the docetaxel-enhanced phosphorylation of the NMDA receptor NR2B subunit in the spinal dorsal horn. These results of the analgesic effect of electrical stimulation in chemotherapy-induced neuropathy could potentially provide a new method to treat and manage peripheral neuropathy in patients with cancer.
C1 [Kang, Suk-Yun; Bang, Se Kyun; Seo, Su-Yeon; Choi, Kwang-Ho; Cho, Seong Jin; Ryu, Yeonhee] KoreaInst Oriental Med, Clin Med Div, 1672 Yuseong Daero, Daejeon 34054, South Korea.
   [Yoo, Hwa Seung] Daejeon Univ, East West Canc Ctr, Dunsan Korean Med Hosp, Daejeon 35234, South Korea.
   [Lee, Jin Sun] Chungnam Natl Univ Hosp, Dept Surg, Daejeon 35015, South Korea.
   [Kim, Hyun-Woo] Chungnam Natl Univ, Dept Physiol & Med Sci, Daejeon 35015, South Korea.
   [Kwon, O. Sang] Wonkwang Univ, Coll Korean Med, Dept Meridian & Acupuncture Points, Iksan 54538, South Korea.
C3 Daejeon University; Chungnam National University; Chungnam National
   University Hospital; Chungnam National University; Wonkwang University
RP Ryu, Y (corresponding author), KoreaInst Oriental Med, Clin Med Div, 1672 Yuseong Daero, Daejeon 34054, South Korea.
EM sy8974@kiom.re.kr; sichosi@kiom.re.kr; logos319@wku.ac.kr;
   ssy1025@kiom.re.kr; ddoongho@kiom.re.kr; ipcng@kiom.re.kr;
   altyhs@daum.net; leejin123@daum.net; kim0827@cnu.ac.kr; yhryu@kiom.re.kr
RI Lee-Bitar, Jin Sun/ISS-9717-2023
OI Kim, Hyun-Woo/0000-0002-8796-8967
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [HI15C0007]; Korea Institute of Oriental Medicine (KIOM;
   Daejeon, South Korea) [KSN1812181]
FX This research was supported by a grant of the Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute
   (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea
   (grant number: HI15C0007). This work was also supported by a grant
   (KSN1812181) from Korea Institute of Oriental Medicine (KIOM; Daejeon,
   South Korea).
CR ABBADIE C, 1994, PAIN, V57, P45, DOI 10.1016/0304-3959(94)90106-6
   Bennett GJ, 2010, ONCOLOGIST, V15, P9, DOI 10.1634/theoncologist.2009-S503
   Bennett MI, 2010, J PAIN, V11, P351, DOI 10.1016/j.jpain.2009.08.002
   BLANCHARD RJ, 1991, PHYSIOL BEHAV, V50, P967, DOI 10.1016/0031-9384(91)90423-L
   Brewer JR, 2016, GYNECOL ONCOL, V140, P176, DOI 10.1016/j.ygyno.2015.11.011
   Cavaletti G, 2010, NAT REV NEUROL, V6, P657, DOI 10.1038/nrneurol.2010.160
   Cervellini I, 2010, NEUROTOX RES, V18, P151, DOI 10.1007/s12640-009-9127-9
   Cho HY, 2014, TOHOKU J EXP MED, V232, P207, DOI 10.1620/tjem.232.207
   Choi JW, 2015, AM J CHINESE MED, V43, P57, DOI 10.1142/S0192415X15500044
   Choi SR, 2017, J PAIN, V18, P415, DOI 10.1016/j.jpain.2016.12.002
   Clark AK, 2009, J NEUROSCI, V29, P6945, DOI 10.1523/JNEUROSCI.0828-09.2009
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Hong JS, 2014, CURR ONCOL, V21, P174, DOI 10.3747/co.21.1984
   Hsieh YL, 2016, ACUPUNCT MED, V34, P398, DOI 10.1136/acupmed-2016-011112
   Huang C, 2000, NEUROSCI LETT, V294, P159, DOI 10.1016/S0304-3940(00)01572-X
   Inagaki H, 2017, PHYSIOL BEHAV, V169, P189, DOI 10.1016/j.physbeh.2016.11.015
   Jaggi AS, 2012, TOXICOLOGY, V291, P1, DOI 10.1016/j.tox.2011.10.019
   Jay GW, 2014, DM-DIS MON, V60, P6, DOI 10.1016/j.disamonth.2013.12.001
   Johnson M, 2007, PAIN, V130, P157, DOI 10.1016/j.pain.2007.02.007
   Kang SY, 2011, BRAIN RES BULL, V86, P412, DOI 10.1016/j.brainresbull.2011.08.012
   Kim HW, 2008, BRAIN RES BULL, V75, P698, DOI 10.1016/j.brainresbull.2007.11.015
   Knutson B, 1998, J COMP PSYCHOL, V112, P65, DOI 10.1037/0735-7036.112.1.65
   Knutson B, 2002, PSYCHOL BULL, V128, P961, DOI 10.1037//0033-2909.128.6.961
   Ko EJ, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12615
   Kurejova M, 2010, MOL PAIN, V6, DOI 10.1186/1744-8069-6-18
   Lim DW, 2018, INFLAMMOPHARMACOLOGY, V26, P207, DOI 10.1007/s10787-017-0389-1
   Litvin Y, 2007, BEHAV BRAIN RES, V182, P166, DOI 10.1016/j.bbr.2006.11.038
   McGinnis MY, 2003, PHYSIOL BEHAV, V80, P81, DOI 10.1016/S0031-9384(03)00227-0
   MICZEK KA, 1995, PSYCHOPHARMACOLOGY, V121, P38, DOI 10.1007/BF02245590
   Mihara Y, 2011, MOL PAIN, V7, DOI 10.1186/1744-8069-7-8
   Park SB, 2013, CA-CANCER J CLIN, V63, P419, DOI 10.3322/caac.21204
   Peng P, 2012, J HUAZHONG U SCI-MED, V32, P586, DOI 10.1007/s11596-012-1001-y
   Portfors CV, 2007, J AM ASSOC LAB ANIM, V46, P28
   Qiao LN, 2017, ACUPUNCT MED, V35, P276, DOI 10.1136/acupmed-2016-011177
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Stubblefield MD, 2009, J NATL COMPR CANC NE, V7, pS1, DOI 10.6004/jnccn.2009.0078
   Takahashi N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014115
   Tsuzuki H, 2012, NEUROREPORT, V23, P937, DOI 10.1097/WNR.0b013e3283595726
   Ventzel L, 2016, PAIN, V157, P560, DOI 10.1097/j.pain.0000000000000404
   von Schlippe M, 2001, BRIT J CANCER, V85, P823, DOI 10.1054/bjoc.2001.2006
   Wang H, 2014, BRIT J ANAESTH, V112, P1075, DOI 10.1093/bja/aeu001
   Yeo JH, 2016, J PAIN, V17, P298, DOI 10.1016/j.jpain.2015.10.018
   Yu XD, 2017, ACUPUNCT MED, V35, P142, DOI 10.1136/acupmed-2016-011063
   Zhou Hong-Yi, 2011, Expert Rev Clin Pharmacol, V4, P379
NR 46
TC 5
Z9 6
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
EI 1873-2747
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD SEP
PY 2020
VL 162
BP 237
EP 244
DI 10.1016/j.brainresbull.2020.06.016
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA MO2BR
UT WOS:000551338700025
PM 32593737
OA hybrid
DA 2026-01-16
ER

PT J
AU Ben-Arye, E
   Hausner, D
   Samuels, N
   Gamus, D
   Lavie, O
   Tadmor, T
   Gressel, O
   Agbarya, A
   Attias, S
   David, A
   Schiff, E
AF Ben-Arye, Eran
   Hausner, David
   Samuels, Noah
   Gamus, Dorit
   Lavie, Ofer
   Tadmor, Tamar
   Gressel, Orit
   Agbarya, Abed
   Attias, Samuel
   David, Adi
   Schiff, Elad
TI Impact of acupuncture and integrative therapies on chemotherapy-induced
   peripheral neuropathy: A multicentered, randomized controlled trial
SO CANCER
LA English
DT Article
DE acupuncture; chemotherapy-induced peripheral neuropathy; integrative
   medicine; integrative oncology; pain
ID QUALITY-OF-LIFE; ONCOLOGY; PREVENTION; SAFETY; PAIN
AB Background To explore the impact of acupuncture with other complementary and integrative medicine (CIM) modalities on chemotherapy-induced peripheral neuropathy (CIPN) and quality of life (QoL) in oncology patients. Methods In this prospective, pragmatic, and patient-preference study, patients with CIPN were treated with acupuncture and CIM therapies (intervention group) or standard care alone (controls) for 6 weeks. Patients in the intervention arm were randomized to twice-weekly acupuncture-only (group A) or acupuncture with additional manual-movement or mind-body CIM therapies (group B). Severity of CIPN was assessed at baseline and at 6 weeks using the Functional Assessment of Cancer Therapy-Taxane (FACT-Tax) tool. Other QoL-related outcomes were assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC); and the Measure Yourself Concerns and Well-being questionnaire. Von Frey measurements examined perception thresholds. Results Of 168 participants, 136 underwent the study intervention (group A, 69; group B, 67), with 32 controls. Baseline-to-6-week assessment scores improved significantly in the intervention arm (vs controls) on FACT-Tax (p = .038) and emotional well-being (p = .04) scores; FACT-TAX scores for hand numbness/tingling (p = .007) and discomfort (p < .0001); and EORTC physical functioning (p = .045). Intervention groups A and B showed improved FACT-Tax physical well-being (p < .001), FACT-TAX total score (p < .001), FACT-TAX feet discomfort (p = .003), and EORTC pain (p = .017) scores. Conclusions Acupuncture, with or without CIM modalities, can relieve CIPN-related symptoms during oncology treatment. This is most pronounced for hand numbness, tingling, pain, discomfort, and for physical functioning.
C1 [Ben-Arye, Eran; Gressel, Orit; Agbarya, Abed] Clalit Hlth Serv, Integrat Oncol Program, Lin Zebulun & Carmel Med Ctr, Oncol Serv, Haifa, Israel.
   [Ben-Arye, Eran; Lavie, Ofer; Tadmor, Tamar; Gressel, Orit; Schiff, Elad] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
   [Hausner, David; Gamus, Dorit] Chaim Sheba Med Ctr, Tal Ctr Integrat Med, Inst Oncol, Ramat Gan, Israel.
   [Hausner, David; David, Adi] Chaim Sheba Med Ctr, Palliat Care Serv, Ramat Gan, Israel.
   [Samuels, Noah] Hebrew Univ Jerusalem, Fac Med, Ctr Integrat Complementary Med, Shaarei Zedek Med Ctr, Jerusalem, Israel.
   [Gamus, Dorit] Sheba Med Ctr, Complementary & Integrat Med Serv, Ramat Gan, Israel.
   [Lavie, Ofer] Carmel Hosp, Dept Obstet & Gynecol, Haifa, Israel.
   [Tadmor, Tamar] Bnai Zion Med Ctr, Unit Hematol, Haifa, Israel.
   [Agbarya, Abed] Bnai Zion Med Ctr, Inst Oncol, Haifa, Israel.
   [Attias, Samuel; Schiff, Elad] Bnai Zion Med Ctr, Dept Internal Med, Haifa, Israel.
   [Attias, Samuel; Schiff, Elad] Bnai Zion Med Ctr, Integrat Med Serv, Haifa, Israel.
C3 Clalit Health Services; Technion Israel Institute of Technology;
   Rappaport Faculty of Medicine; Tel Aviv University; Chaim Sheba Medical
   Center; Chaim Sheba Medical Center; Tel Aviv University; Hebrew
   University of Jerusalem; Shaare Zedek Medical Center; Tel Aviv
   University; Chaim Sheba Medical Center; Clalit Health Services; Carmel
   Medical Center; Bnai Zion Medical Center; Bnai Zion Medical Center; Bnai
   Zion Medical Center; Bnai Zion Medical Center
RP Ben-Arye, E (corresponding author), Lin Med Ctr, Oncol Serv, 35 Rothschild St, Haifa, Israel.
EM eranben@netvision.net.il
RI David, Adi/LBI-5899-2024; hausner, david/AAW-9363-2020; Agbarya,
   Abed/JGZ-5006-2023
OI David, Adi/0009-0008-0617-9933; hausner, david/0009-0008-8623-0347;
   Agbarya, Abed/0000-0002-3330-2959
FU Adelis Foundation
FX Funded by the Adelis Foundation.
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   Alberti P, 2021, NEUROLOGY, V97, pE660, DOI 10.1212/WNL.0000000000012300
   Bao T, 2021, ONCOLOGIST, V26, pE2070, DOI 10.1002/onco.13933
   Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Ben-Arye E, 2022, PSYCHO-ONCOLOGY, V31, P207, DOI 10.1002/pon.5794
   Ben-Arye E, 2013, MED ONCOL, V30, DOI 10.1007/s12032-013-0511-1
   Cardoso F, 2018, ANN ONCOL, V29, P1634, DOI 10.1093/annonc/mdy192
   Cavaletti G, 2010, EUR J CANCER, V46, P479, DOI 10.1016/j.ejca.2009.12.008
   Cella D, 2003, CANCER-AM CANCER SOC, V98, P822, DOI 10.1002/cncr.11578
   Cioroiu C, 2017, CURR NEUROL NEUROSCI, V17, DOI 10.1007/s11910-017-0757-7
   Cybularz PA, 2015, MED ACUPUNCT, V27, P224, DOI 10.1089/acu.2015.1099
   Frenkel M, 2010, INTEGR CANCER THER, V9, P276, DOI 10.1177/1534735410378663
   Grant SJ, 2019, SUPPORT CARE CANCER, V27, P2069, DOI 10.1007/s00520-018-4460-2
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Huang CC, 2021, J CLIN MED, V10, DOI 10.3390/jcm10163694
   Iravani S, 2020, PAIN RES MANAG, V2020, DOI 10.1155/2020/2504674
   Kerner H, 2020, BMJ SUPPORT PALLIAT, V10, DOI 10.1136/bmjspcare-2017-001351
   Keshet Y, 2015, PSYCHO-ONCOLOGY, V24, P169, DOI 10.1002/pon.3621
   Kolb NA, 2016, JAMA NEUROL, V73, P860, DOI 10.1001/jamaneurol.2016.0383
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Lu WD, 2010, CURR TREAT OPTION ON, V11, P141, DOI 10.1007/s11864-010-0126-0
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Manni L, 2011, ARCH ITAL BIOL, V149, P247, DOI 10.4449/aib.v149i2.1365
   Pachman DR, 2011, CLIN PHARMACOL THER, V90, P377, DOI 10.1038/clpt.2011.115
   Rossi C., 2021, INTEGR CANCER THER, V20, p15347354211040826, DOI [10.1177/15347354211040826, DOI 10.1177/15347354211040826]
   Schröder S, 2007, EUR J NEUROL, V14, P276, DOI 10.1111/j.1468-1331.2006.01632.x
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Shalom-Sharabi I, 2017, J CANCER RES CLIN, V143, P2535, DOI 10.1007/s00432-017-2509-0
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Wang XM, 2012, CYTOKINE, V59, P3, DOI 10.1016/j.cyto.2012.03.027
   Zhao XM, 2019, PHYSIOL RES, V68, P501, DOI 10.33549/physiolres.934084
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zhi WI, 2019, BREAST CANCER RES TR, V178, P587, DOI 10.1007/s10549-019-05416-4
NR 33
TC 37
Z9 40
U1 4
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD OCT
PY 2022
VL 128
IS 20
BP 3641
EP 3652
DI 10.1002/cncr.34422
EA AUG 2022
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 4W5ZY
UT WOS:000839602000001
PM 35960141
DA 2026-01-16
ER

PT J
AU McDonald, J
   Graca, S
   Citkovitz, C
   Taylor-Swanson, L
AF McDonald, John
   Graca, Sandro
   Citkovitz, Claudia
   Taylor-Swanson, Lisa
TI Turning Point: A Review of Key Research and Engagement in 2022
SO JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review
ID SHAM ACUPUNCTURE; PAIN; OSTEOARTHRITIS; GUIDELINES; MANAGEMENT;
   SYMPTOMS; SOCIETY; CANCER
C1 [McDonald, John] Endeavour Coll Nat Hlth, Sch Chinese Med, Gold Coast, Qld, Australia.
   [Graca, Sandro] Northern Coll Acupuncture, Dept Res, York, England.
   [Citkovitz, Claudia] Massachusetts Coll Pharm & Hlth Sci, New England Sch Acupuncture, Worcester, MA USA.
   [Taylor-Swanson, Lisa] Univ Utah, Coll Nursing, Salt Lake City, UT USA.
   [Taylor-Swanson, Lisa] Univ Utah, Coll Nursing, Annette Cummings Bldg,10 South 2000 East, Salt Lake City, UT 84112 USA.
C3 Endeavour College of Natural Health; Utah System of Higher Education;
   University of Utah; Utah System of Higher Education; University of Utah
RP Taylor-Swanson, L (corresponding author), Univ Utah, Coll Nursing, Annette Cummings Bldg,10 South 2000 East, Salt Lake City, UT 84112 USA.
EM lisa.taylor-swanson@nurs.utah.edu
RI Graca, Sano/AGN-6704-2022; McDonald, John/AAF-9285-2020
OI Graca, Sano/0000-0002-3538-4038; McDonald, John/0000-0002-8317-0069;
   Taylor-Swanson, Lisa/0000-0002-9116-6369
CR [Anonymous], 2021, NICE guideline NG193
   [Anonymous], Acupuncture
   AWMF, 2021, GUID PROGR ONC GERM
   Bae K, 2023, CRIT REV ONCOL HEMAT, V181, DOI 10.1016/j.critrevonc.2022.103898
   Baroncini A, 2022, J ORTHOP SURG RES, V17, DOI 10.1186/s13018-022-03212-3
   Birch S, 2022, Perspectives on Integrative Medicine, V1, P3, DOI [10.56986/pim.2022.09.002, 10.56986/pim.2022.09.002, DOI 10.56986/PIM.2022.09.002]
   Birch S, 2022, PHYTOMEDICINE, V104, DOI 10.1016/j.phymed.2022.154297
   Birch S, 2022, INTEGR MED RES, V11, DOI 10.1016/j.imr.2021.100725
   Birch S, 2021, EUR J INTEGR MED, V41, DOI 10.1016/j.eujim.2020.101257
   Birch S, 2020, J ALTERN COMPLEM MED, V26, P784, DOI 10.1089/acm.2020.0032
   Birch S, 2018, J ALTERN COMPLEM MED, V24, P752, DOI 10.1089/acm.2018.0092
   Birch S, 2019, INTEGR MED RES, V8, P160, DOI 10.1016/j.imr.2019.05.002
   Birch S, 2019, INTEGR MED RES, V8, P33, DOI 10.1016/j.imr.2018.07.005
   Birch S, 2017, J ALTERN COMPLEM MED, V23, P242, DOI 10.1089/acm.2016.0385
   BMJ, 2022, Coronavirus disease 2019 (COVID-19)
   Castellini G, 2022, J PHYSIOTHER, V68, P244, DOI 10.1016/j.jphys.2022.09.007
   Corbett MS, 2013, OSTEOARTHR CARTILAGE, V21, P1290, DOI 10.1016/j.joca.2013.05.007
   Cummings M, 2023, Perspectives on Integrative Medicine, V2, P3, DOI 10.56986/pim.2023.02.002
   Davis HE, 2023, NAT REV MICROBIOL, V21, P133, DOI 10.1038/s41579-022-00846-2
   de Valois B, 2022, SUPPORT CARE CANCER, V30, P5063, DOI 10.1007/s00520-022-06898-7
   Demarquay G, 2021, REV NEUROL-FRANCE, V177, P753, DOI 10.1016/j.neurol.2021.07.009
   Downstate Health Sciences University, SUNY DOWNST MED RES
   Hershman DL, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.41720
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Iwamura APD, 2021, REV MED VIROL, V31, DOI 10.1002/rmv.2199
   Lam WC, 2021, AM J MED, V134, P1286, DOI 10.1016/j.amjmed.2021.05.002
   Langevin HM, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1155/2011/180805
   Li HC, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj-2021-067477
   Li M, 2022, ACUPUNCT MED, V40, P203, DOI 10.1177/09645284211041125
   Li Ruo-Qi, 2022, Zhongguo Zhen Jiu, V42, P1431, DOI 10.13703/j.0255-2930.20220513-0002
   Li RY, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000032383
   Li YC, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11050860
   Lu LM, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-056803
   Lu LM, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj-2021-067475
   Luo D, 2022, FRONT MOL NEUROSCI, V15, DOI 10.3389/fnmol.2022.817738
   Ma Y, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168123
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mao JJ, 2023, J INTEGR COMPLEMENT, V29, P209, DOI 10.1089/jicm.2023.0018
   Morita A, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.916944
   National Institute for Health and Care Excellence (NICE), 2020, NICE Guideline, No. 59
   NICE, 2021, HEAD 12S DIAGN MAN C
   NICE, 2022, OST 16S DIAGN MAN NI
   Oh JE, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.813748
   PubMed, MESH UN ID D017065 P
   Qaseem Amir, 2017, Ann Intern Med, V166, P514, DOI 10.7326/M16-2367
   Shao TH, 2023, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.1051581
   Trento MMS, 2021, PFLUG ARCH EUR J PHY, V473, P573, DOI 10.1007/s00424-020-02503-0
   Svenkerud S, 2018, ACUPUNCT MED, V36, P349, DOI 10.1136/acupmed-2017-011519
   Tang XR, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-058834
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Wan RH, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.829409
   Wang L, 2023, APPL NURS RES, V70, DOI 10.1016/j.apnr.2022.151651
   Wang XC, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000031243
   Wu T, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.1026971
   Yi T, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.885020
   Zhang YQ, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj-2021-067476
   Zhang YQ, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj-2022-070533
   Zheng H, 2022, NEUROLOGY, V99, pE1560, DOI 10.1212/WNL.0000000000200670
NR 58
TC 2
Z9 2
U1 1
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2768-3605
EI 2768-3613
J9 J INTEGR COMPLEMENT
JI J. Integr. Complement. Med.
PD AUG 1
PY 2023
VL 29
IS 8
BP 455
EP 461
DI 10.1089/jicm.2023.0283
EA JUL 2023
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA P1PA4
UT WOS:001030624700001
PM 37462909
DA 2026-01-16
ER

PT J
AU Xu, Y
   Zhao, WL
   Li, T
   Zhao, Y
   Bu, HE
   Song, SL
AF Xu, Yang
   Zhao, Wenli
   Li, Te
   Zhao, Ye
   Bu, Huaien
   Song, Shilin
TI Effects of acupuncture for the treatment of endometriosis-related pain:
   A systematic review and meta-analysis
SO PLOS ONE
LA English
DT Review
ID PELVIC PAIN; CA-125; WOMEN; SURGERY; QUALITY; CANCER; LIFE
AB Background
   Endometriosis is a multifactorial, oestrogen-dependent, inflammatory, gynaecological condition that can result in long-lasting visceral pelvic pain and infertility. Acupuncture could be an effective treatment for endometriosis and may relieve pain. Our aim in the present study was to determine the effectiveness of acupuncture as a treatment for endometriosis-related pain.
   Methods
   In December 2016, six databases were searched for randomised controlled trials that determined the effectiveness of acupuncture in the treatment of endometriosis-related pain. Ultimately, 10 studies involving 589 patients were included. The main outcomes assessed were variation in pain level, variation in peripheral blood CA-125 level, and clinical effective rate. All analyses were performed using comprehensive meta-analysis statistical software.
   Results
   Of the 10 studies included, only one pilot study used a placebo control and assessed blinding; the rest used various controls (medications and herbs), which were impossible to blind. The sample sizes were small in all studies, ranging from 8 to 36 patients per arm. The mean difference (MD) in pain reduction (pre-minus post-interventional pain level D measured on a 0-10-point scale) between the acupuncture and control groups was 1.36 (95% confidence intervals [ CI] = 1.01-1.72, P<0.0001). Acupuncture had a positive effect on peripheral blood CA-125 levels, as compared with the control groups (MD = 5.9, 95% CI = 1.56-10.25, P = 0.008). Similarly, the effect of acupuncture on clinical effective rate was positive, as compared with the control groups (odds ratio = 2.07; 95% CI = 1.24-3.44, P = 0.005).
   Conclusions
   Few randomised, blinded clinical trials have addressed the efficacy of acupuncture in treating endometriosis-related pain. Nonetheless, the current literature suggests that acupuncture reduces pain and serum CA-125 levels, regardless of the control intervention used. To confirm these findings, additional, blinded studies with proper controls and adequate sample sizes are needed.
C1 [Xu, Yang] Tianjin Acad Integrat Med, Nankai Hosp, Dept Gynecol & Obstet, Tianjin, Peoples R China.
   [Zhao, Wenli] Tianjin Univ Tradit Chinese Med, Grad Sch, Tianjin, Peoples R China.
   [Zhao, Wenli] Tianjin Acad Integrat Med, Nankai Hosp, Dept Neurol, Tianjin, Peoples R China.
   [Li, Te] Tianjin Hearing Impairment Specialist Hosp, Dept Chinese Med, Tianjin, Peoples R China.
   [Zhao, Ye] Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA.
   [Bu, Huaien] Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Dept Publ Hlth, Tianjin, Peoples R China.
   [Song, Shilin] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Lab Anat, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; State University
   System of Florida; University of Florida; Tianjin University of
   Traditional Chinese Medicine; Tianjin University of Traditional Chinese
   Medicine
RP Bu, HE (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Dept Publ Hlth, Tianjin, Peoples R China.; Song, SL (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Lab Anat, Tianjin, Peoples R China.
EM buhuaien@163.com; haiguagua@163.com
CR Abbott JA, 2003, HUM REPROD, V18, P1922, DOI 10.1093/humrep/deg275
   Ahn SH, 2016, FERTIL STERIL, V106, P1420, DOI 10.1016/j.fertnstert.2016.07.005
   Amaral Vivian Ferreira do, 2006, Sao Paulo Med. J., V124, P223
   Amer S., 2008, Obstet. Gynaecol. Reprod. Med, V18, P126
   ANDERSSON S, 1995, MED HYPOTHESES, V45, P271, DOI 10.1016/0306-9877(95)90117-5
   [Anonymous], ACUPUNCTURE RES
   [Anonymous], 2015, [No title captured]
   BARBIERI RL, 1986, FERTIL STERIL, V45, P630
   Brawn J, 2014, HUM REPROD UPDATE, V20, P737, DOI 10.1093/humupd/dmu025
   Chen GX., 2014, THESIS, P16
   Chen Ming, 2010, Zhongguo Zhen Jiu, V30, P725
   Chen QX, 2015, THESIS, P16
   CHEN S, 2014, EVID-BASED COMPL ALT, V2014, DOI DOI 10.1155/2014/609594
   Cheng YM, 2002, OBSTET GYNECOL, V99, P375, DOI 10.1016/S0029-7844(01)01731-8
   DIZEREGA GS, 1980, FERTIL STERIL, V33, P649
   EISERMANN J, 1988, FERTIL STERIL, V50, P573
   Fedele L, 2004, AM J OBSTET GYNECOL, V190, P1020, DOI 10.1016/j.ajog.2003.10.698
   Ferrero S, 2005, FERTIL STERIL, V83, P573, DOI 10.1016/j.fertnstert.2004.07.973
   Higgins J., 2011, COCHRANE COLLABORATI
   Hui KK, 2006, INTEGR CANCER THER, V5, P56, DOI 10.1177/1534735405286109
   Hui KKS, 2005, NEUROIMAGE, V27, P479, DOI 10.1016/j.neuroimage.2005.04.037
   JACOBS I, 1988, LANCET, V1, P889
   Johnston MF, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nep236
   Kaludjerovic J, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/837901
   Kennedy S, 2005, HUM REPROD, V20, P2698, DOI 10.1093/humrep/dei135
   Liu YX, 2003, XIN ZHONG YI, V35, P55
   Liu YY., 2009, HUBEI J TRADITIONAL, V31, P53
   Lund I, 2016, J PAIN RES, V9, P157, DOI 10.2147/JPR.S55580
   Ma Jie, 2008, Zhen Ci Yan Jiu, V33, P235
   Miller JD, 2000, AM J OBSTET GYNECOL, V182, P1483, DOI 10.1067/mob.2000.106846
   Scheerer C, 2016, ARCH GYNECOL OBSTET, V294, P657, DOI 10.1007/s00404-016-4142-6
   Staud R, 2006, EXPERT REV NEUROTHER, V6, P661, DOI 10.1586/14737175.6.5.661
   Sun Yuan-Zheng, 2006, Zhongguo Zhen Jiu, V26, P863
   Tian LY, 2016, CLIN J TRAD CHIN MED, P670
   Tian X, 2014, ALTERN THER HEALTH M, V20, P33
   Torres-Rosas R, 2014, NAT MED, V20, P291, DOI 10.1038/nm.3479
   Vercellini P, 2009, HUM REPROD UPDATE, V15, P177, DOI 10.1093/humupd/dmn062
   Wang M, 1991, ZHONGGUO ZHONG XI YI, V11
   Wayne PM, 2008, J PEDIATR ADOL GYNEC, V21, P247, DOI 10.1016/j.jpag.2007.07.008
   Wieser F, 2007, HUM REPROD UPDATE, V13, P487, DOI 10.1093/humupd/dmm015
   Wu JX, 2013, J EMERG TRADIT CHIN, P1947
   Xiang Dong-Fang, 2011, Zhongguo Zhen Jiu, V31, P113
   Yan Hong, 2008, Zhongguo Zhen Jiu, V28, P579
   Zhang Xinxin, 2015, Zhongguo Zhen Jiu, V35, P323
   Zhen R, 2009, YI XUE LI LUN YU SHI, V22, P571
   Zhu XS, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007864.pub2
NR 46
TC 52
Z9 62
U1 2
U2 26
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 27
PY 2017
VL 12
IS 10
AR e0186616
DI 10.1371/journal.pone.0186616
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FK9WD
UT WOS:000413861200014
PM 29077705
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, XY
   Shen, QY
   Hu, XY
   Liang, Y
AF Wang, Xiaoying
   Shen, Qiongying
   Hu, Xinyi
   Liang, Yi
TI Comment on 'Efficacy and Safety of Different Acupuncture Treatments for
   Cancer-Related Pain: A Systematic Review and Network Meta-Analysis'
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Letter
C1 [Wang, Xiaoying; Shen, Qiongying; Hu, Xinyi; Liang, Yi] Zhejiang Chinese Med Univ, Clin Med Coll 3, Hangzhou, Zhejiang, Peoples R China.
   [Liang, Yi] Zhejiang Chinese Med Univ, Affiliated Hosp 3, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical University
RP Wang, XY (corresponding author), Zhejiang Chinese Med Univ, Clin Med Coll 3, Hangzhou, Zhejiang, Peoples R China.
RI shen, qiongying/KVB-9873-2024
OI Liang, Yi/0000-0002-6440-6144
CR Beets MW, 2023, SYST REV-LONDON, V12, DOI 10.1186/s13643-023-02184-7
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n160, 10.1136/bmj.n71, 10.1038/nchembio.2180, 10.1186/s40900-023-00424-7, 10.3390/jpm13020373]
   Sun N, 2019, ACUPUNCT MED, V37, P261, DOI 10.1136/acupmed-2017-011608
   Xie TL, 2025, INTEGR CANCER THER, V24, DOI 10.1177/15347354251314500
NR 4
TC 0
Z9 0
U1 2
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2025
VL 24
AR 15347354251344281
DI 10.1177/15347354251344281
PG 2
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA 3BH1P
UT WOS:001496236100001
PM 40417861
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yeo, JH
   Yoon, SY
   Kwon, SK
   Kim, SJ
   Lee, JH
   Beitz, AJ
   Roh, DH
AF Yeo, Ji-Hee
   Yoon, Seo-Yeon
   Kwon, Soon-Keun
   Kim, Sol-Ji
   Lee, Jang-Hern
   Beitz, Alvin J.
   Roh, Dae-Hyun
TI Repetitive Acupuncture Point Treatment with Diluted Bee Venom Relieves
   Mechanical Allodynia and Restores Intraepidermal Nerve Fiber Loss in
   Oxaliplatin-Induced Neuropathic Mice
SO JOURNAL OF PAIN
LA English
DT Article
DE Bee venom; oxaliplatin; mechanical allodynia; intraepidermal nerve
   fibers; alpha-2 adrenoceptors
ID INDUCED PERIPHERAL NEUROPATHY; REDUCES NOCICEPTIVE RESPONSES; MOUSE
   FORMALIN TEST; ACUPOINT STIMULATION; THERMAL HYPERALGESIA;
   COLORECTAL-CANCER; PAIN MODEL; ACTIVATION; PACLITAXEL; INJECTION
AB The chemotherapeutic agent, oxaliplatin, produces a robust painful neuropathy that results in the loss of intraepidermal nerve fibers (IENFs). We have previously reported that an acupuncture point (acupoint) injection of diluted bee venom (DBV) produces a temporary antiallodynic effect in oxaliplatin-induced neuropathic mice. Herein we show a significant long-lasting antinociceptive effect of repetitive DBV acupoint treatment on oxaliplatin-induced mechanical allodynia and a significant reduction in the loss of IENFs. DBV (0.1 mg/kg, subcutaneous) was administered once a day for 18 days beginning on day 15 after oxaliplatin injection. Immunohistochemistry for IENF was performed on the glabrous skin of the hind paw footpad using the pan-neuronal marker, protein gene product 9.5. A temporary increase in mechanical threshold was observed 60 minutes after a single DBV injection into the Zusanli acupoint, and this effect was enhanced over time with repetitive DBV treatments. The basal mechanical threshold before daily DBV injection also increased from day, 7 after DBV injections, and peaked at day 14 after DBV treatment. Moreover, the oxaliplatininduced loss of IENFs was significantly reduced in mice treated repetitively with DBV. Repetitive pretreatment with the alpha-2 adrenoceptor antagonist, yohimbine, (5 mg/kg, subcutaneous) completely prevented the antiallodynic effects and the increase in IENFs observed in mice treated repetitively with DBV.
   Perspective: We showed that repetitive acupoint stimulation with DBV gradually and significantly reduced oxaliplatin-induced mechanical allodynia and restored the loss of IENFs in neuropathic mice via an alpha-2 adrenoceptor mechanism. Collectively, results of this study suggest that repetitive acupoint treatment with DBV can be a potential strategy for the management of chemotherapy induced neuropathy. (C) 2016 by the American Pain Society
C1 [Yeo, Ji-Hee; Kwon, Soon-Keun; Kim, Sol-Ji; Roh, Dae-Hyun] Kyung Hee Univ, Sch Dent, Dept Oral Physiol, Seoul 130701, South Korea.
   [Yeo, Ji-Hee; Kwon, Soon-Keun; Kim, Sol-Ji; Roh, Dae-Hyun] Kyung Hee Univ, Sch Dent, Res Ctr Tooth & Periodontal Tissue Regenerat, Seoul 130701, South Korea.
   [Yoon, Seo-Yeon] Seoul Natl Univ, Coll Nat Sci, Dent Res Inst, Dept Brain & Cognit Sci, Seoul 151742, South Korea.
   [Yoon, Seo-Yeon] Seoul Natl Univ, Sch Dent, Dept Neurobiol & Physiol, Seoul, South Korea.
   [Lee, Jang-Hern] Seoul Natl Univ, Coll Vet Med, Dept Vet Physiol, Seoul, South Korea.
   [Beitz, Alvin J.] Univ Minnesota, Coll Vet Med, Dept Vet & Biomed Sci, St Paul, MN 55108 USA.
C3 Kyung Hee University; Kyung Hee University; Seoul National University
   (SNU); Seoul National University (SNU); Seoul National University (SNU);
   University of Minnesota System; University of Minnesota Twin Cities
RP Roh, DH (corresponding author), Kyung Hee Univ, Sch Dent, Dept Oral Physiol, Seoul 130701, South Korea.
EM dhroh@khu.ac.kr
RI ; Roh, Dae-Hyun/HPE-3599-2023
OI Beitz, Alvin/0000-0002-2640-2628; Yeo, Jihee/0000-0001-7171-3786; Roh,
   Dae-Hyun/0000-0002-5139-5458
FU National Research Foundation of Korea (NRF) - Korea government (MSIP)
   [2012R1A5A2051385]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIP; No. 2012R1A5A2051385).
CR Argyriou AA, 2008, CANCER TREAT REV, V34, P368, DOI 10.1016/j.ctrv.2008.01.003
   Attal N, 2009, PAIN, V144, P245, DOI 10.1016/j.pain.2009.03.024
   Bell MT, 2014, J THORAC CARDIOV SUR, V147, P500, DOI 10.1016/j.jtcvs.2013.07.043
   Bennett GJ, 2011, EUR J NEUROSCI, V33, P1667, DOI 10.1111/j.1460-9568.2011.07652.x
   Binder A, 2007, EUR J CANCER, V43, P2658, DOI 10.1016/j.ejca.2007.07.030
   Boyette-Davis J, 2011, EXP NEUROL, V229, P353, DOI 10.1016/j.expneurol.2011.02.019
   Boyette-Davis J, 2011, PAIN, V152, P308, DOI 10.1016/j.pain.2010.10.030
   Chao Hui-Lin, 2013, Oncol Nurs Forum, V40, pE61, DOI 10.1188/13.ONF.E61-E68
   Darwish SF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079284
   de Hoyos JAG, 2004, PAIN, V112, P289, DOI 10.1016/j.pain.2004.08.030
   Forsyth PA, 1997, J NEURO-ONCOL, V35, P47, DOI 10.1023/A:1005805907311
   Fu S, 2006, INT J GYNECOL CANCER, V16, P1717, DOI 10.1111/j.1525-1438.2006.00654.x
   Gao YH, 2013, NEUROCHEM RES, V38, P1467, DOI 10.1007/s11064-013-1047-7
   Grothey A, 2010, ONCOLOGY-BASEL, V79, P389, DOI 10.1159/000323491
   Han YQ, 2013, FRONT PHARMACOL, V4, DOI 10.3389/fphar.2013.00156
   Huang C, 2004, BRAIN RES BULL, V63, P99, DOI 10.1016/j.brainresbull.2004.01.006
   Kang SY, 2012, J PAIN, V13, P155, DOI 10.1016/j.jpain.2011.10.012
   Kennedy WR, 1996, NEUROLOGY, V47, P1042, DOI 10.1212/WNL.47.4.1042
   Kim HW, 2005, PHARMACOL RES, V51, P183, DOI 10.1016/j.phrs.2004.07.011
   Kim HW, 2006, BRIT J PHARMACOL, V148, P490, DOI 10.1038/sj.bjp.0706764
   Kwon YB, 2005, PHARMACOL BIOCHEM BE, V80, P181, DOI 10.1016/j.pbb.2004.10.017
   Kwon YB, 2004, MOL CELLS, V17, P329
   Kwon YB, 2001, NEUROSCI LETT, V308, P133, DOI 10.1016/S0304-3940(01)01989-9
   Kwon YB, 2001, PAIN, V90, P271, DOI 10.1016/S0304-3959(00)00412-7
   Kwon YB, 2006, NEUROSCI RES, V55, P197, DOI 10.1016/j.neures.2006.03.003
   Lauria G, 2005, EUR J NEUROL, V12, P747, DOI 10.1111/j.1468-1331.2005.01260.x
   Lee JH, 2001, J VET MED SCI, V63, P251, DOI 10.1292/jvms.63.251
   Lee JA, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-006140
   Lee Sun-Hwa, 2014, Exp Neurobiol, V23, P86, DOI 10.5607/en.2014.23.1.86
   LINDSAY RM, 1988, J NEUROSCI, V8, P2394
   McArthur JC, 1998, ARCH NEUROL-CHICAGO, V55, P1513, DOI 10.1001/archneur.55.12.1513
   Musazzi L, 2014, INT J NEUROPSYCHOPH, V17, P779, DOI 10.1017/S1461145713001685
   Nolano M, 1999, PAIN, V81, P135, DOI 10.1016/S0304-3959(99)00007-X
   Oaklander AL, 2006, PAIN, V120, P235, DOI 10.1016/j.pain.2005.09.036
   Oaklander AL, 2001, PAIN, V92, P139, DOI 10.1016/S0304-3959(00)00481-4
   Paranos SL, 2013, FUND CLIN PHARMACOL, V27, P319, DOI 10.1111/j.1472-8206.2011.01018.x
   Petersen KL, 2010, PAIN, V150, P75, DOI 10.1016/j.pain.2010.04.002
   POSTMA TJ, 1995, ANN ONCOL, V6, P489, DOI 10.1093/oxfordjournals.annonc.a059220
   Quasthoff S, 2002, J NEUROL, V249, P9, DOI 10.1007/PL00007853
   Raez LE, 2010, CLIN LUNG CANCER, V11, P18, DOI 10.3816/CLC.2010.n.003
   Roh DH, 2006, J PAIN, V7, P500, DOI 10.1016/j.jpain.2006.02.002
   Roh DH, 2014, BIOL PHARM BULL, V37, P145, DOI 10.1248/bpb.b13-00690
   Roh DH, 2004, J PAIN, V5, P297, DOI 10.1016/j.jpain.2004.05.003
   Schreiber S, 2002, BRAIN RES BULL, V58, P601, DOI 10.1016/S0361-9230(02)00825-0
   Shin SH, 2014, BIOL PHARM BULL, V37, P1295, DOI 10.1248/bpb.b14-00102
   Shun CT, 2004, BRAIN, V127, P1593, DOI 10.1093/brain/awh180
   Siau C, 2006, EXP NEUROL, V201, P507, DOI 10.1016/j.expneurol.2006.05.007
   Sisignano M, 2014, NAT REV NEUROL, V10, P694, DOI 10.1038/nrneurol.2014.211
   SOMERFIELD SD, 1988, J RHEUMATOL, V15, P1878
   Stein A, 2012, EXPERT OPIN PHARMACO, V13, P125, DOI 10.1517/14656566.2012.643870
   Tofthagen C, 2011, CLIN J ONCOL NURS, V15, P182, DOI 10.1188/11.CJON.182-188
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Walk D, 2007, J NEUROL SCI, V255, P23, DOI 10.1016/j.jns.2007.01.052
   Yoon SY, 2012, NEUROSCIENCE, V221, P214, DOI 10.1016/j.neuroscience.2012.06.024
   Yoon SY, 2008, NEUROSCI LETT, V430, P163, DOI 10.1016/j.neulet.2007.10.035
   Yoon SY, 2007, NEUROSCI RES, V59, P51, DOI 10.1016/j.neures.2007.05.008
   Yoon SY, 2015, ANESTH ANALG, V120, P671, DOI 10.1213/ANE.0000000000000607
   Yoon SY, 2013, BIOL PHARM BULL, V36, P1787, DOI 10.1248/bpb.b13-00469
   Yoon SY, 2013, J PAIN, V14, P205, DOI 10.1016/j.jpain.2012.11.002
   Yoon SY, 2009, J PAIN, V10, P253, DOI 10.1016/j.jpain.2008.09.002
   Zheng H, 2012, EXP NEUROL, V238, P225, DOI 10.1016/j.expneurol.2012.08.023
NR 61
TC 27
Z9 31
U1 1
U2 15
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD MAR
PY 2016
VL 17
IS 3
BP 298
EP 309
DI 10.1016/j.jpain.2015.10.018
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DH3FH
UT WOS:000372672400003
PM 26604098
OA Bronze
DA 2026-01-16
ER

PT J
AU Li, HJ
   Schlaeger, JM
   Patil, CL
   Danciu, O
   Chen, ZJ
   Lif, N
   Gao, S
   Doorenbos, AZ
AF Li, Hongjin
   Schlaeger, Judith M.
   Patil, Crystal L.
   Danciu, Oana
   Chen, Zhengjia
   Lif, Natalie
   Gao, Shuang
   Doorenbos, Ardith Z.
TI Feasibility of implementing acupuncture in medically underserved breast
   cancer survivors (FAB): A protocol
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Acupuncture; Breast cancer; Multiple symptoms; Underserved; Barriers;
   Facilitators
ID ALTERNATIVE MEDICINE; CONTROLLED-TRIAL; HOT FLASHES;
   SOCIOECONOMIC-FACTORS; AROMATASE INHIBITORS; VASOMOTOR SYMPTOMS;
   ENDOCRINE THERAPY; DOUBLE-BLIND; DUAL-CENTER; WOMEN
AB Nearly 94% of breast cancer survivors experience one or more symptoms or side effects during or after endocrine therapy. Joint pain, hot flashes, sleep disturbance, fatigue, depression, and anxiety are the most common concurrent symptoms, some of which can persist for 5 to 10 years. Acupuncture is a holistic modality that addresses multiple symptoms and side effects in a single therapy. Acupuncture has not yet been investigated for its effectiveness in treating the multiple symptoms experienced by breast cancer survivors receiving endocrine therapy. Medically underserved breast cancer survivors typically have limited access to acupuncture. The barriers limiting access to acupuncture need to be removed to enable equal access to breast cancer survivors for this evidence-based treatment. Thus, we developed a randomized controlled trial with a 5-week acupuncture intervention versus usual care for medically underserved breast cancer survivors. Mixed methods (semi-structured interviews, surveys, study notes) will be used to obtain in-depth understanding of barriers and facilitators for eventual implementation of the acupuncture intervention. This study will facilitate the widespread implementation, dissemination, and sustained utilization of acupuncture for symptom management among medically underserved breast cancer survivors receiving endocrine therapy.
C1 [Li, Hongjin; Schlaeger, Judith M.; Patil, Crystal L.; Lif, Natalie] Univ Illinois, Chicago Coll Nursing, Dept Human Dev Nursing Sci, 845 S Damen Ave M-C 802, Chicago, IL 60612 USA.
   [Li, Hongjin; Chen, Zhengjia; Doorenbos, Ardith Z.] Univ Illinois, Canc Ctr, 818 South Wolcott Ave, Chicago, IL 60612 USA.
   [Danciu, Oana] Univ Illinois, Chicago Coll Med, Dept Hematol Oncol, 820 S Wood St Suite 172 CSN M-C 712, Chicago, IL 60612 USA.
   [Gao, Shuang] Univ Illinois, Chicago Coll Med, 1853 W Polk St, Chicago, IL 60612 USA.
   [Doorenbos, Ardith Z.] Univ Illinois, Chicago Coll Nursing, Dept Biobehav Nursing Sci, 845 S Damen Ave M-C 802, Chicago, IL 60612 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Li, HJ (corresponding author), Univ Illinois, Chicago Coll Nursing, Dept Human Dev Nursing Sci, 845 S Damen Ave M-C 802, Chicago, IL 60612 USA.
EM hongjin@uic.edu
RI Patil, Crystal/H-7509-2016; schlaeger, judith/N-4482-2017
OI Patil, Crystal/0000-0003-4536-4599; 
FU National Center for Complementary & Integrative Health [R34AT012084]
FX This work was supported by the National Center for Complementary &
   Integrative Health (R34AT012084) .
CR Alcalá HE, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-930
   Anderson BJ, 2021, J ALTERN COMPLEM MED, V27, P496, DOI 10.1089/acm.2020.0394
   [Anonymous], HLTH PEOPLE 2030
   Awan A, 2018, CURR ONCOL, V25, P285, DOI 10.3747/co.25.4139
   Bao T, 2018, INTEGR CANCER THER, V17, P854, DOI 10.1177/1534735418754309
   Bao T, 2014, CANCER-AM CANCER SOC, V120, P381, DOI 10.1002/cncr.28352
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Bender CM, 2021, SUPPORT CARE CANCER, V29, P3743, DOI 10.1007/s00520-020-05865-4
   Biglia N, 2012, EUR J CANCER CARE, V21, P485, DOI 10.1111/j.1365-2354.2011.01320.x
   Bokmand S, 2013, BREAST, V22, P320, DOI 10.1016/j.breast.2012.07.015
   Borrelli B, 2005, J CONSULT CLIN PSYCH, V73, P852, DOI 10.1037/0022-006X.73.5.852
   Bowles EJA, 2012, J ONCOL PRACT, V8, pE149, DOI 10.1200/JOP.2012.000543
   Brauer JA, 2010, J ALTERN COMPLEM MED, V16, P183, DOI 10.1089/acm.2009.0354
   Burstein HJ, 2019, J CLIN ONCOL, V37, P423, DOI 10.1200/JCO.18.01160
   Cessna JM, 2016, J PSYCHOSOM RES, V81, P9, DOI 10.1016/j.jpsychores.2015.12.002
   Chao MT, 2019, PAIN MED, V20, P2292, DOI 10.1093/pm/pnz117
   Chao MT, 2008, ETHNIC DIS, V18, P65
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Damschroder LJ, 2009, IMPLEMENT SCI, V4, DOI 10.1186/1748-5908-4-50
   Deng G, 2007, J CLIN ONCOL, V25, P5584, DOI 10.1200/JCO.2007.12.0774
   Deng G, 2013, SUPPORT CARE CANCER, V21, P1735, DOI 10.1007/s00520-013-1720-z
   Doorenbos Ardith Z, 2014, Kango Kenkyu, V47, P207
   Ferlay J, 2021, INT J CANCER, V149, P778, DOI 10.1002/ijc.33588
   Frisk J, 2008, CLIMACTERIC, V11, P166, DOI 10.1080/13697130801958709
   Garland SN, 2019, JNCI-J NATL CANCER I, V111, P1323, DOI 10.1093/jnci/djz050
   Garland SN, 2017, MENOPAUSE, V24, P517, DOI 10.1097/GME.0000000000000779
   Garreau JR, 2006, AM J SURG, V192, P496, DOI 10.1016/j.amjsurg.2006.06.018
   Giovanni M., 1989, The Foundations of Chinese Medicine: A Comprehensive Text for Acupuncturists and Herbalists, P219
   Harris PA, 2019, J BIOMED INFORM, V95, DOI 10.1016/j.jbi.2019.103208
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hervik J, 2009, BREAST CANCER RES TR, V116, P311, DOI 10.1007/s10549-008-0210-3
   Kegler MC, 2018, HEALTH SERV RES, V53, P4178, DOI 10.1111/1475-6773.13035
   Kwekkeboom KL, 2020, ONCOL NURS FORUM, V47, P498, DOI 10.1188/20.ONF.498-511
   Langevin HM, 2021, J ALTERN COMPLEM MED, V27, P623, DOI 10.1089/acm.2021.0255
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Li HJ, 2023, BIOL RES NURS, V25, P326, DOI 10.1177/10998004221136567
   Liljegren A, 2012, BREAST CANCER RES TR, V135, P791, DOI 10.1007/s10549-010-1283-3
   Liou KT, 2023, JNCI CANCER SPECT, V7, DOI 10.1093/jncics/pkad042
   Ludwick A, 2020, PAIN MANAG NURS, V21, P142, DOI 10.1016/j.pmn.2019.08.005
   Mao JJ, 2021, JAMA ONCOL, V7, P720, DOI 10.1001/jamaoncol.2021.0310
   Mao JJ, 2015, J CLIN ONCOL, V33, P3615, DOI 10.1200/JCO.2015.60.9412
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Mao JJ, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/798098
   Mckee MD, 2012, J ALTERN COMPLEM MED, V18, P839, DOI 10.1089/acm.2011.0193
   Miles M B., 1994, Qualitative Data Analysis: An Expanded Sourcebook
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Mostafaei F, 2021, HELIYON, V7, DOI 10.1016/j.heliyon.2021.e07657
   Natl Acad Sci Engn Med, 2017, COMMUNITIES IN ACTION: PATHWAYS TO HEALTH EQUITY, P1, DOI 10.17226/24624
   Nedstrand E, 2006, J PSYCHOSOM OBST GYN, V27, P193, DOI 10.1080/01674820600724797
   Ng CG, 2015, HEALTH QUAL LIFE OUT, V13, DOI 10.1186/s12955-015-0401-7
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Peeters R, 2023, MED CARE RES REV, V80, P266, DOI [10.1177/10775587221118156, 10.1111/eva.13711]
   Pitman A, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k1415
   Quach CW, 2016, QUAL LIFE RES, V25, P2811, DOI 10.1007/s11136-016-1325-3
   Saper R., 2016, Integrative medicine and health disparities
   Schillinger MDD, 2020, STUD HEALTH TECHNOL, V269, P22, DOI 10.3233/SHTI200020
   Schumacher J.R., 2021, 2021 AM SOC BREAST S
   Smith C, 2013, ACUPUNCT MED, V31, P9, DOI 10.1136/acupmed-2012-010228
   Su DJ, 2011, J HEALTH CARE POOR U, V22, P296, DOI 10.1353/hpu.2011.0002
   Vallerand AH, 2005, PAIN MED, V6, P242, DOI 10.1111/j.1526-4637.2005.05038.x
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   Wang SM, 2008, ANESTH ANALG, V106, P602, DOI 10.1213/01.ane.0000277493.42335.7b
   Wilkie DJ, 2003, J PAIN SYMPTOM MANAG, V25, P213, DOI 10.1016/S0885-3924(02)00638-3
   Wilkie DJ, 2001, FAM COMMUNITY HEALTH, V24, P48, DOI 10.1097/00003727-200110000-00007
   Yin X, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.20563
   Zhang Y, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/710750
   Zhu YH, 2019, CANCER NURS, V42, pE19, DOI 10.1097/NCC.0000000000000632
NR 68
TC 3
Z9 3
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD JAN
PY 2024
VL 136
AR 107387
DI 10.1016/j.cct.2023.107387
EA NOV 2023
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CS5B1
UT WOS:001127231900001
PM 37972754
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Cassileth, BR
   Van Zee, KJ
   Yeung, KS
   Coleton, MI
   Cohen, S
   Chan, YH
   Vickers, AJ
   Sjoberg, DD
   Hudis, CA
AF Cassileth, Barrie R.
   Van Zee, Kimberly J.
   Yeung, K. Simon
   Coleton, Marci I.
   Cohen, Sara
   Chan, Yi H.
   Vickers, Andrew J.
   Sjoberg, Daniel D.
   Hudis, Clifford A.
TI Acupuncture in the treatment of upper-limb lymphedema Results of a Pilot
   Study
SO CANCER
LA English
DT Article
DE axillary lymphadenectomy; acupuncture; lymphedema intervention; breast
   carcinoma; manual lymph drainage; complex decongestive therapy
ID QUALITY-OF-LIFE; BREAST-CANCER PATIENTS; CONTROLLED-TRIALS; ARM
   LYMPHEDEMA; SURVIVORS; WOMEN; MULTICENTER; RELIABILITY; MANAGEMENT; PAIN
AB BACKGROUND Current treatments for lymphedema after breast cancer treatment are expensive and require ongoing intervention. Clinical experience and our preliminary published results suggest that acupuncture is safe and potentially useful. This study evaluates the safety and potential efficacy of acupuncture on upper-limb circumference in women with lymphedema. METHODS Women with a clinical diagnosis of breast cancer-related lymphedema (BCRL) for 0.5-5 years and with affected arm circumference 2 cm larger than unaffected arm received acupuncture treatment twice weekly for 4 weeks. Affected and unaffected arm circumferences were measured before and after each acupuncture treatment. Response, defined as 30% reduction in circumference difference between affected/unaffected arms, was assessed. Monthly follow-up calls for 6 months thereafter were made to document any complications and self-reported lymphedema status. RESULTS Among 37 enrolled patients, 33 were evaluated; 4 discontinued due to time constraints. Mean reduction in arm circumference difference was 0.90 cm (95% CI, 0.72-1.07; P<.0005). Eleven patients (33%) exhibited a reduction of 30% after acupuncture treatment. Seventy-six percent of patients received all treatments; 21% missed 1 treatment, and another patient missed 2 treatments. During the treatment period, 14 of the 33 patients reported minor complaints, including mild local bruising or pain/tingling. There were no serious adverse events and no infections or severe exacerbations after 255 treatment sessions and 6 months of follow-up interviews. CONCLUSIONS Acupuncture for BCRL appears safe and may reduce arm circumference. Although these results await confirmation in a randomized trial, acupuncture can be considered for women with no other options for sustained arm circumference reduction. Cancer 2013;119:2455-2461. (c) 2013 American Cancer Society.
C1 [Cassileth, Barrie R.; Yeung, K. Simon; Coleton, Marci I.; Chan, Yi H.; Vickers, Andrew J.; Sjoberg, Daniel D.] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, New York, NY 10021 USA.
   [Van Zee, Kimberly J.] Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10021 USA.
   [Cohen, Sara; Hudis, Clifford A.] Mem Sloan Kettering Canc Ctr, Breast Canc Med Serv, New York, NY 10021 USA.
   [Sjoberg, Daniel D.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering
   Cancer Center
RP Cassileth, BR (corresponding author), Mem Sloan Kettering Canc Ctr, Integrat Med Serv, 1429 1st Ave, New York, NY 10021 USA.
EM Cassileth@mskcc.org
RI ; Hudis, Clifford/AAW-9482-2021; Sjoberg, Daniel/B-8001-2011
OI Van Zee, Kimberly/0000-0001-9550-4647; Yeung,
   Kwokwai/0000-0002-4930-4895; Sjoberg, Daniel/0000-0003-0862-2018;
   Vickers, Anew/0000-0003-1525-6503
FU Laurance S. Rockefeller Fund; National Cancer Institute [P30CA008748]
   Funding Source: NIH RePORTER
FX This study was supported in part by the Laurance S. Rockefeller Fund.
CR Ahmed RL, 2008, J CLIN ONCOL, V26, P5689, DOI 10.1200/JCO.2008.16.4731
   Alem M, 2008, ACUPUNCT MED, V26, P86, DOI 10.1136/aim.26.2.86
   [Anonymous], Breast Cancer Facts and Figures 2009-2010
   BC Cancer Agency, LYMPH PROV HLTH SERV
   Beaulac SM, 2002, ARCH SURG-CHICAGO, V137, P1253, DOI 10.1001/archsurg.137.11.1253
   Bland KL, 2003, AM J SURG, V186, P509, DOI 10.1016/j.amjsurg.2003.07.003
   BRADY MS, 1994, ANN SURG ONCOL, V1, P66, DOI 10.1007/BF02303543
   Cassileth BR, 2011, ACUPUNCT MED, V29, P170, DOI 10.1136/aim.2011.004069
   Chao J, 2009, COCHRANE DATABASE SY, DOI 10.1016/j.bcp.2017.06.123
   Chen J, AM SOC CLIN ONC 2009
   Chen YW, 2008, AM J PHYS MED REHAB, V87, P33, DOI 10.1097/PHM.0b013e31815b6199
   Cormier JN, 2010, CANCER-AM CANCER SOC, V116, P5138, DOI 10.1002/cncr.25458
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   de Godoy JMP, 2002, LYMPHOLOGY, V35, P72
   Deltombe T, 2007, LYMPHOLOGY, V40, P26
   Franks PJ, 2006, WOUND REPAIR REGEN, V14, P110, DOI 10.1111/j.1743-6109.2006.00099.x
   Ganz PA, 1999, NEW ENGL J MED, V340, P383, DOI 10.1056/NEJM199902043400511
   Gottschling S, 2008, KLIN PADIATR, V220, P365, DOI 10.1055/s-0028-1086039
   Haake M, 2007, ARCH INTERN MED, V167, P1892, DOI 10.1001/archinte.167.17.1892
   Harris SR, 2001, CAN MED ASSOC J, V164, P191
   Hayes SC, 2012, CANCER-AM CANCER SOC, V118, P2237, DOI 10.1002/cncr.27467
   He J. P., 1999, Clinical and Experimental Obstetrics and Gynecology, V26, P81
   Kanakura Y, 2002, AM J CHINESE MED, V30, P37, DOI 10.1142/S0192415X02000041
   Kim KH, 2010, MENOPAUSE, V17, P269, DOI 10.1097/gme.0b013e3181bfac3b
   Lee MS, 2011, CHIN J INTEGR MED, V17, P187, DOI 10.1007/s11655-011-0665-7
   Lee Sang-Hun, 2011, Curr Urol Rep, V12, P288, DOI 10.1007/s11934-011-0186-0
   Lu WD, 2010, INTEGR CANCER THER, V9, P284, DOI 10.1177/1534735410378856
   McLaughlin SA, 2008, J CLIN ONCOL, V26, P5213, DOI 10.1200/JCO.2008.16.3725
   Melchart D, 2004, ARCH INTERN MED, V164, P104, DOI 10.1001/archinte.164.1.104
   Mercado-Poe C, 2008, SOC INT ONC 5 INT C
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P3, DOI 10.1016/j.ctim.2006.07.005
   National Cancer Institute, 2012, LYMPH PDQ DIAGN EV
   Paskett ED, 2007, CANCER EPIDEM BIOMAR, V16, P775, DOI 10.1158/1055-9965.EPI-06-0168
   Petrek JA, 2001, CANCER, V92, P1368, DOI 10.1002/1097-0142(20010915)92:6<1368::AID-CNCR1459>3.0.CO;2-9
   Pfister DG, 2010, J CLIN ONCOL, V28, P2565, DOI 10.1200/JCO.2009.26.9860
   Poage E, 2008, CLIN J ONCOL NURS, V12, P951, DOI 10.1188/08.CJON.951-964
   Pyszel A, 2006, LYMPHOLOGY, V39, P185
   Sagen Å, 2009, ACTA ONCOL, V48, P1111, DOI 10.3109/02841860903061691
   Selfe TK, 2008, FAM COMMUNITY HEALTH, V31, P247, DOI 10.1097/01.FCH.0000324482.78577.0f
   Shah C, 2011, INT J RADIAT ONCOL, V81, P907, DOI 10.1016/j.ijrobp.2011.05.043
   Shiflett SC, 2011, BJOG-INT J OBSTET GY, V118, P100, DOI 10.1111/j.1471-0528.2010.02758.x
   Shih YCT, 2009, J CLIN ONCOL, V27, P2007, DOI 10.1200/JCO.2008.18.3517
   Taylor R, 2006, PHYS THER, V86, P205, DOI 10.1093/ptj/86.2.205
   Vickers AJ, 2004, J CLIN ONCOL, V22, P1731, DOI 10.1200/JCO.2004.04.102
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   Wang SM, 2008, ANESTH ANALG, V107, P811, DOI 10.1213/ane.0b013e3181804441
   Wang SM, 2007, J ALTERN COMPLEM MED, V13, P241, DOI 10.1089/acm.2006.6262
   Witt CM, 2009, FORSCH KOMPLEMENTMED, V16, P91, DOI 10.1159/000209315
   Wong Raimond, 2006, Acupunct Med, V24, P87
NR 49
TC 52
Z9 59
U1 0
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD JUL 1
PY 2013
VL 119
IS 13
BP 2455
EP 2461
DI 10.1002/cncr.28093
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 165FT
UT WOS:000320469400016
PM 23576267
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Li, BY
   Liu, CZ
   Zhou, H
   Wei, XY
   Jia, JY
   Wang, J
   Guo, XY
   Liang, W
   Tu, JF
   Wang, LQ
   Shi, GX
   Yang, JW
   Yang, NN
AF Li, Bin-Yan
   Liu, Cun-Zhi
   Zhou, Hang
   Wei, Xiao-Ya
   Jia, Jin-Ying
   Wang, Jun
   Guo, Xiao-Yan
   Liang, Wei
   Tu, Jian-Feng
   Wang, Li-Qiong
   Shi, Guangxia
   Yang, Jing-Wen
   Yang, Na-Na
TI Acupuncture for preventing chemotherapy-induced peripheral neuropathy:
   study protocol for a randomised controlled trial
SO BMJ OPEN
LA English
DT Article
DE Acupuncture; CHEMOTHERAPY; Clinical Trial; Neurological injury
ID CLINICAL-PRACTICE GUIDELINES; INTEGRATIVE ONCOLOGY; LUNG-CANCER;
   SEVERITY; WOMEN; PAIN; CIPN
AB Introduction Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent non-haematological, dose-limiting adverse event associated with platinum derivatives and taxanes. Currently, no effective prophylactic interventions for CIPN have been established. However, several studies have shown that acupuncture may alleviate symptoms of peripheral neuropathy, proposing it as a potentially effective strategy for CIPN prevention. This pilot trial will help determine the feasibility and efficacy of acupuncture for preventing CIPN. The results will provide valuable insights for designing a larger clinical trial and conducting power calculations.Methods and analysis This is a randomised sham-controlled trial. A cohort of 60 patients scheduled to receive chemotherapy will be enrolled and randomly assigned to either the electroacupuncture group or the sham acupuncture group. Eligible patients will receive nine treatment sessions administered over the course of three chemotherapy cycles. The primary outcome is the change in CIPN-related quality of life (QOL) measured by the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) CIPN20 from baseline to the end of cycle three. Secondary outcomes include: neurotoxicity symptoms assessed by the Numeric Rating Scale, incidence of CIPN, chemotherapy status, insomnia symptoms measured by the Insomnia Severity Index, depression symptoms evaluated using the Beck Depression Inventory-II, anxiety symptoms assessed with the Generalised Anxiety Disorder-7 and fatigue symptoms measured by the Brief Fatigue Inventory. Adverse events will be meticulously recorded.Ethics and dissemination The study protocol (V.1.0, 29 July 2024) has been approved by the First Affiliated Hospital of Zhengzhou University (2024-KY-0853-001). All patients will provide oral informed consent and written informed consent before participating in this study. Trial results will be disseminated in peer-reviewed publications.Trial registration number ITMCTR2024000390 (International Traditional Medicine Clinical Trial Registry, http://itmctr.ccebtcm.org.cn/zh-CN/Home/ProjectView?pid=16387992-8971-4218-9cd0-b623af91f9f3), registered on 3 September 2024.
C1 [Li, Bin-Yan; Liu, Cun-Zhi; Zhou, Hang; Wei, Xiao-Ya; Tu, Jian-Feng; Wang, Li-Qiong; Shi, Guangxia; Yang, Jing-Wen; Yang, Na-Na] Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
   [Jia, Jin-Ying; Wang, Jun; Guo, Xiao-Yan; Liang, Wei] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China.
C3 Beijing University of Chinese Medicine; Zhengzhou University
RP Yang, NN (corresponding author), Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
EM lby05192022@163.com; lcz623780@126.com; 2721955078@qq.com;
   xiaoya0414@vip.qq.com; 436008247@qq.com; zywj1968@163.com;
   guo_xiaoyan88@163.com; lllwww2016@163.com; tujianfeng1@126.com;
   wangliqiongwork@163.com; shiguangxia2008@126.com; yangjw0626@126.com;
   1254614551@qq.com
RI Liu, Cunzhi/J-9190-2017; Tu, Jian-Feng/J-7768-2017
FU Qihuang Scholar Project of the National Administration of Traditional
   Chinese Medicine
FX This trial is supported by the Qihuang Scholar Project of the National
   Administration of Traditional Chinese Medicine. The funding bodies have
   no roles in study design, collection, management, analysis,
   interpretation of data, writing of the report or the decision to submit
   the report for publication.
CR [Anonymous], 1988, NUTR REV, V46, P12
   Bang H, 2016, CONT CLIN TRIAL COMM, V3, P117, DOI 10.1016/j.conctc.2016.05.003
   Bao T, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.0681
   Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Bao T, 2011, PAIN RES TREAT, V2011, DOI 10.1155/2011/920807
   Beck AT, 1996, J PERS ASSESS, V67, P588, DOI 10.1207/s15327752jpa6703_13
   Beijers AJM, 2020, ANN ONCOL, V31, P131, DOI 10.1016/j.annonc.2019.09.006
   Brewer JR, 2016, GYNECOL ONCOL, V140, P176, DOI 10.1016/j.ygyno.2015.11.011
   Cassileth BR, 2007, CHEST, V132, p340S, DOI 10.1378/chest.07-1389
   Chan KY, 2023, ACUPUNCT MED, V41, P268, DOI 10.1177/09645284221125421
   Chine VB, 2019, MOL NEUROBIOL, V56, P3244, DOI 10.1007/s12035-018-1301-8
   Das M, 2017, LANCET ONCOL, V18, pE202, DOI 10.1016/S1470-2045(17)30182-1
   De Falco V, 2019, ESMO OPEN, V4, DOI 10.1136/esmoopen-2020-000813
   Denduluri N, 2018, CLIN BREAST CANCER, V18, P380, DOI 10.1016/j.clbc.2018.02.003
   Desai N, 2022, JAMA INTERN MED, V182, P766, DOI 10.1001/jamainternmed.2022.1812
   Devilly GJ, 2000, J BEHAV THER EXP PSY, V31, P73, DOI 10.1016/S0005-7916(00)00012-4
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Farrar JT, 2001, PAIN, V94, P149, DOI 10.1016/S0304-3959(01)00349-9
   Flatters SJL, 2017, BRIT J ANAESTH, V119, P737, DOI 10.1093/bja/aex229
   Gewandter JS, 2020, SUPPORT CARE CANCER, V28, P2553, DOI 10.1007/s00520-019-05063-x
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Huang MC, 2023, ONCOLOGIST, V28, pE436, DOI 10.1093/oncolo/oyad065
   James KE, 1996, STAT MED, V15, P1421
   Jordan B, 2020, ANN ONCOL, V31, P1306, DOI 10.1016/j.annonc.2020.07.003
   Joseph N, 2015, GYNECOL ONCOL, V137, P401, DOI 10.1016/j.ygyno.2015.03.052
   Li K, 2019, CURR ONCOL, V26, pE147, DOI 10.3747/co.26.4261
   Li TFY, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.24139
   Loprinzi CL, 2020, J CLIN ONCOL, V38, DOI 10.1200/JCO.20.01399
   Lu ZX, 2017, J ALTERN COMPLEM MED, V23, P964, DOI 10.1089/acm.2017.0052
   Ma YY, 2023, J EXP CLIN CANC RES, V42, DOI 10.1186/s13046-023-02804-z
   Macklin EA, 2006, HYPERTENSION, V48, P838, DOI 10.1161/01.HYP.0000241090.28070.4c
   Mendoza TR, 1999, CANCER-AM CANCER SOC, V85, P1186, DOI 10.1002/(SICI)1097-0142(19990301)85:5<1186::AID-CNCR24>3.0.CO;2-N
   Park SB, 2009, J CLIN ONCOL, V27, P1243, DOI 10.1200/JCO.2008.19.3425
   Pei LX, 2023, ACUPUNCT MED, V41, P73, DOI 10.1177/09645284221076512
   Postma TJ, 2005, EUR J CANCER, V41, P1135, DOI 10.1016/j.ejca.2005.02.012
   Singh N, 2010, J THORAC ONCOL, V5, P236, DOI 10.1097/JTO.0b013e3181c3f5f7
   Smith EML, 2013, QUAL LIFE RES, V22, P2787, DOI 10.1007/s11136-013-0379-8
   Spitzer RL, 2006, ARCH INTERN MED, V166, P1092, DOI 10.1001/archinte.166.10.1092
   Wang XS, 2004, J PAIN SYMPTOM MANAG, V27, P322, DOI 10.1016/j.jpainsymman.2003.09.008
   Wang Y, 2023, JAMA SURG, V158, P20, DOI 10.1001/jamasurg.2022.5674
   Windebank AJ, 2008, J PERIPHER NERV SYST, V13, P27, DOI 10.1111/j.1529-8027.2008.00156.x
   Winters-Stone KM, 2017, J CLIN ONCOL, V35, P2604, DOI 10.1200/JCO.2016.71.3552
   Wolf SL, 2012, SUPPORT CARE CANCER, V20, P625, DOI 10.1007/s00520-011-1141-9
   Xu ZH, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.963358
   Yang YH, 2012, SUPPORT CARE CANCER, V20, P1491, DOI 10.1007/s00520-011-1237-2
   Yeo F, 2019, SUPPORT CARE CANCER, V27, P4753, DOI 10.1007/s00520-019-04771-8
   Yusufov M, 2019, PSYCHO-ONCOLOGY, V28, P540, DOI 10.1002/pon.4973
NR 48
TC 0
Z9 0
U1 16
U2 16
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUL 29
PY 2025
VL 15
IS 7
AR e102588
DI 10.1136/bmjopen-2025-102588
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5MR6F
UT WOS:001539330200001
PM 40730402
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Ha Kim, M
   Cho, HM
   Kim, SH
   Kim, Y
   Shin, YK
   Kim, KH
AF Ha Kim, Min
   Cho, Hyun Min
   Kim, Seon Hee
   Kim, Youngwoong
   Shin, Yu Kyung
   Kim, Kun Hyung
TI Prevalence of and factors associated with trauma surgeons' referral and
   patients' willingness to acupuncture treatment after traumatic rib
   fractures: A single-center cross-sectional study
SO INTEGRATIVE MEDICINE RESEARCH
LA English
DT Article
DE Acupuncture; Cross-sectional study; Injury; Pain; Rib fracture
ID ELECTRICAL NERVE-STIMULATION; ALTERNATIVE MEDICINE; PAIN MANAGEMENT;
   POSTOPERATIVE PAIN; COMPLEMENTARY; CANCER; PHYSICIANS; MORBIDITY;
   MORTALITY; ATTITUDES
AB Background: Pain after traumatic rib fractures (TRF) detrimentally affects the injured. Multidisciplinary pain management is crucial for patient care. There is little empirical evidence on acupuncture as a multidisciplinary treatment for patients with TRF. This study aimed to illustrate the characteristics of the patients referred for or received acupuncture and explore the associated factors. Methods: We conducted a cross-sectional study of Korean Trauma Data Bank and electronic medical records of patients aged 19 or older with TRF from August 2016 to October 2021 in the regional trauma center of Pusan National University Hospital. The sociodemographic and clinical characteristics of patients referred for acupuncture by trauma surgeons and those who received acupuncture were analysed descriptively. In multivariable logistic regression analyses, associations between covariates and either surgeon referrals for or patient willingness to receive acupuncture were quantitatively estimated. Results: Among 2,937 injured patients, trauma surgeons referred 178 (6.1 %) to acupuncture. Among the referred patients, 111 (72.1 %) underwent acupuncture. Patients with polytrauma (aOR 0.46; 0.30 to 0.68) were less likely to be referred to acupuncture, whereas female patients (aOR 3.92, 1.31 to 11.77) were most likely to receive acupuncture. Conclusions: A small proportion of patients with TRF were referred for acupuncture, but the referred patients were more likely to receive acupuncture. Polytrauma may be an important criterion for referral to acupuncture services from the perspective of trauma surgeons, while the willingness to receive acupuncture may be associated with gender-related factors. Further studies are warranted to investigate the role of acupuncture in the postinjury care of patients with TRF.
C1 [Ha Kim, Min] Kyung Hee Univ, Korean Med Hosp, Seoul, South Korea.
   [Cho, Hyun Min] Jeju Halla Gen Hosp, Jeju Prov Trauma Ctr, Dept Trauma Surg & Crit Care, Jeju, Jeju, South Korea.
   [Kim, Seon Hee] Pusan Natl Univ, Sch Med, Dept Trauma & Surg Crit Care, Busan, South Korea.
   [Kim, Youngwoong] Asan Med Ctr, Dept Thorac & Cardiovasc Surg, Seoul, South Korea.
   [Kim, Seon Hee; Kim, Kun Hyung] Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea.
   [Kim, Kun Hyung] Pusan Natl Univ, Sch Korean Med, 20 Geumo Ro, Yangsan Si 50612, Gyeongsangnam D, South Korea.
   [Kim, Kun Hyung] Pusan Natl Univ, Korean Med Hosp, Dept Acupuncture & Moxibust Med, Yangsan, South Korea.
   [Shin, Yu Kyung] Pusan Natl Univ, Korean Med Hosp, Clin Res Ctr Korean Med, Yangsan, South Korea.
C3 Kyung Hee University; Kyung Hee University Hospital; Pusan National
   University; University of Ulsan; Asan Medical Center; Pusan National
   University; Pusan National University Hospital; Pusan National
   University; Pusan National University; Pusan National University
RP Kim, KH (corresponding author), Pusan Natl Univ, Sch Korean Med, 20 Geumo Ro, Yangsan Si 50612, Gyeongsangnam D, South Korea.
EM pdchrist@pusan.ac.kr
RI kim, seon hee/GNH-6610-2022
OI Kim, Minha/0009-0009-9323-2962; Kim, Kun Hyung/0000-0002-3471-2431
FU Financial Supporting Project of Long-term Overseas Dispatch of PNU's
   Tenure-track Faculty
FX This work was supported by the Financial Supporting Project of Long-term
   Overseas Dispatch of PNU's Tenure-track Faculty. The fund-ing body had
   no role in the study design and did not play any role during its
   execution, analyses, interpretation of data, or decision to submit the
   report for publication.
CR Alwhaibi M, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/2067095
   [Anonymous], 1971, JAMA, V215, P277
   Bao T, 2018, ACUPUNCT MED, V36, P80, DOI 10.1136/acupmed-2017-011435
   Barraco D, 2005, COMPLEMENT THER MED, V13, P34, DOI 10.1016/j.ctim.2005.02.003
   Bartley EJ, 2013, BRIT J ANAESTH, V111, P52, DOI [10.1097/01.sa.0000484819.20819.8b, 10.1093/bja/aet127]
   Bishop FL, 2010, EVID-BASED COMPL ALT, V7, P11, DOI 10.1093/ecam/nen023
   BOYD CR, 1987, J TRAUMA, V27, P370, DOI 10.1097/00005373-198704000-00005
   Butcher N, 2012, INJURY, V43, P196, DOI 10.1016/j.injury.2011.06.029
   Carrie C, 2018, ANAESTH CRIT CARE PA, V37, P211, DOI 10.1016/j.accpm.2017.05.008
   Chen L, 2010, PAIN MED, V11, P530, DOI 10.1111/j.1526-4637.2010.00815.x
   Curtis K, 2022, INJURY, V53, P2939, DOI 10.1016/j.injury.2022.04.024
   DOWNIE WW, 1978, ANN RHEUM DIS, V37, P378, DOI 10.1136/ard.37.4.378
   Elboim-Gabyzon M, 2019, CLIN INTERV AGING, V14, P1841, DOI 10.2147/CIA.S203658
   Fabricant L, 2013, AM J SURG, V205, P511, DOI 10.1016/j.amjsurg.2012.12.007
   Frenzel S, 2017, SCAND J TRAUMA RESUS, V25, DOI 10.1186/s13049-017-0400-2
   Galvagno SM, 2016, J TRAUMA ACUTE CARE, V81, P936, DOI 10.1097/TA.0000000000001209
   Gerbershagen HJ, 2011, BRIT J ANAESTH, V107, P619, DOI 10.1093/bja/aer195
   Gordy S, 2014, AM J SURG, V207, P659, DOI 10.1016/j.amjsurg.2013.12.012
   Guo SQ, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-056691
   김건형, 2018, Journal of Acupuncture Research, V35, P95, DOI [10.13045/jar.2018.00108, 10.13045/jar.2018.00108]
   정경원, 2016, Journal of Acute Care Surgery, V6, P11, DOI 10.17479/jacs.2016.6.1.11
   Jung K, 2022, PLOS GLOB PUBL HLTH, V2, DOI 10.1371/journal.pgph.0000162
   Jung K, 2019, J KOREAN MED SCI, V34, DOI 10.3346/jkms.2019.34.e65
   Keene MR, 2019, COMPLEMENT THER CLIN, V35, P33, DOI 10.1016/j.ctcp.2019.01.004
   Kilper A, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2020-037192
   Kim KH, 2021, ACUPUNCT MED, V39, P603, DOI 10.1177/09645284211009539
   Kim M, 2020, CURR ANESTHESIOL REP, V10, P61, DOI 10.1007/s40140-020-00374-w
   Kristoffersen AE, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-463
   Lederer AK, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03746-3
   Lim B, 2013, INTEGR MED RES, V2, P81, DOI 10.1016/j.imr.2013.06.004
   Lim Jin-Woong, 2021, [Journal of Korean Medicine, 대한한의학회지], V42, P12, DOI [10.13048/jkm.21002, 10.13048/jkm.21002]
   Mak JCS, 2009, INTERN MED J, V39, P164, DOI 10.1111/j.1445-5994.2008.01734.x
   Mann B, 2016, PAIN MED, V17, P494, DOI 10.1093/pm/pnv001
   Marasco S, 2015, INJURY, V46, P61, DOI 10.1016/j.injury.2014.06.014
   May L, 2016, BJA EDUC, V16, P26, DOI 10.1093/bjaceaccp/mkv011
   Nielsen A, 2022, PAIN MED, V23, P1582, DOI 10.1093/pm/pnac056
   Oncel M, 2002, EUR J CARDIO-THORAC, V22, P13, DOI 10.1016/S1010-7940(02)00206-3
   Palmer Cameron, 2007, Annu Proc Assoc Adv Automot Med, V51, P13
   Peek J, 2020, TRAUMA SURG ACUTE CA, V5, DOI 10.1136/tsaco-2020-000441
   Phutrakool P, 2022, SYST REV-LONDON, V11, DOI 10.1186/s13643-021-01882-4
   pnuhtc.pnuh.or.kr/trauma, History of Pusan National University Hospital Regional Trauma Center
   Sirmali M, 2003, EUR J CARDIO-THORAC, V24, P133, DOI 10.1016/S1010-7940(03)00256-2
   Vana PG, 2014, AM SURGEON, V80, P527
   Veysi VT, 2009, INT ORTHOP, V33, P1425, DOI 10.1007/s00264-009-0746-9
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Walker PH, 2016, NURS OUTLOOK, V64, P491, DOI 10.1016/j.outlook.2016.07.008
   Wang SM, 2003, ANESTH ANALG, V97, P1010, DOI 10.1213/01.ANE.0000078578.75597.F3
   Wang SM, 2002, J ALTERN COMPLEM MED, V8, P351, DOI 10.1089/10755530260128041
   Welfare MoHa, 2020, Report on the evaluation for 3rd stage Western Medicine Korean Medicine collaboration project
   Welfare MoHa, 2022, Korean Medicine use survey basic report of general public, P27
   Witt Cordelie E, 2017, Trauma Surg Acute Care Open, V2, pe000064, DOI [10.1136/tsaco-2016-000064, 10.1136/tsaco-2016-000064]
   Yu XD, 2020, TRIALS, V21, DOI 10.1186/s13063-019-3892-4
   Zhang RX, 2014, ANESTHESIOLOGY, V120, P482, DOI 10.1097/ALN.0000000000000101
   Zhang Y, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/413173
   Zhou X, 2021, CANCER MANAG RES, V13, P1449, DOI 10.2147/CMAR.S292325
   ZIEGLER DW, 1994, J TRAUMA, V37, P975, DOI 10.1097/00005373-199412000-00018
NR 56
TC 1
Z9 1
U1 2
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4220
EI 2213-4239
J9 INTEGR MED RES
JI Integr. Med. Res.
PD DEC
PY 2024
VL 13
IS 4
AR 101096
DI 10.1016/j.imr.2024.101096
EA NOV 2024
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA M9E3J
UT WOS:001360485900001
PM 39635075
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lu, C
   Li, GL
   Deng, DH
   Li, RR
   Li, XY
   Feng, XK
   Wu, TP
   Shao, XY
   Chen, WJ
AF Lu, Chao
   Li, Guangliang
   Deng, Dehou
   Li, Rongrong
   Li, Xiaoyu
   Feng, Xukang
   Wu, Taoping
   Shao, Xiying
   Chen, Weiji
TI Efficacy of electroacupuncture in the treatment of peripheral neuropathy
   caused by Utidelone: Study protocol for a randomized controlled trial
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE breast cancer; electroacupuncture (EA); Utidelone (UTD1);
   chemotherapy-induced peripheral neuropathy (CIPN); peripheral neuropathy
   (PN); protocol
ID QUALITY-OF-LIFE; EUROPEAN-ORGANIZATION; PLUS CAPECITABINE;
   PAIN-INTENSITY; CHEMOTHERAPY; QUESTIONNAIRE; ACUPUNCTURE; RELIABILITY;
   VALIDITY; SCALES
AB Introduction: Utidelone (UTD1) is a new chemotherapeutic drug for recurrent or metastatic breast cancer. However, it usually leads to severe peripheral neuropathy (PN) and causes numbness of the hands and feet and significant pain in patients' life. Electroacupuncture (EA) is considered beneficial in improving PN and relieving numbness of the hands and feet. This trial aims to evaluate the therapeutic effect of EA on PN caused by UTD1 in patients with advanced breast cancer.Methods and analysis: This study is a prospective randomized controlled trial. A total of 70 patients with PN caused by UTD1 will be randomly assigned to the EA treatment group and the control group in a ratio of 1:1. The patients in the EA treatment group will receive 2 Hz EA three times a week for 4 weeks. The patients in the control group will take mecobalamin (MeCbl) tablets orally, one tablet each, three times a day for 4 weeks. The main outcome measures will be the evaluation scale of peripheral neurotoxicity of chemotherapeutic drugs according to the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-CIPN 20-item (EORTC QLQ-CIPN20) and the peripheral neurotoxicity assessment rating according to NCI CTCAE version 5.0. Secondary outcomes will be the quality of life scale according to the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30). The results will be evaluated at baseline, post-treatment phase, and follow-up. All major analyses will be based on the intention-to-treat principle.Ethics and dissemination: This protocol was approved by the Medical Ethics Committee of Zhejiang Cancer Hospital on 26 July 2022. The license number is IRB-2022-425. This study will provide clinical efficacy data on EA in the treatment of PN caused by UTD1 and will help to prove whether EA is an effective and safe therapy. The study results will be shared with healthcare professionals through the publication of manuscripts and conference reports.
C1 [Lu, Chao; Deng, Dehou] Zhejiang Canc Hosp, Dept Tradit Chinese Med, Hangzhou, Peoples R China.
   [Li, Guangliang; Shao, Xiying] Zhejiang Canc Hosp, Dept Breast Med Oncol, Hangzhou, Peoples R China.
   [Li, Rongrong; Li, Xiaoyu; Chen, Weiji] Zhejiang Chinese Med Univ, Zhongshan Hosp Zhejiang Prov, Dept Acupuncture & Moxibust, Affiliated Hosp 3, Hangzhou, Peoples R China.
   [Li, Xiaoyu; Feng, Xukang; Wu, Taoping] Zhejiang Chinese Med Univ, Clin Med Coll 3, Hangzhou, Peoples R China.
C3 Zhejiang Cancer Hospital; Zhejiang Cancer Hospital; Zhejiang Chinese
   Medical University; Zhejiang Chinese Medical University
RP Chen, WJ (corresponding author), Zhejiang Chinese Med Univ, Zhongshan Hosp Zhejiang Prov, Dept Acupuncture & Moxibust, Affiliated Hosp 3, Hangzhou, Peoples R China.
EM chenweiji163@163.com
RI Lu, Chao/ODK-2866-2025; Li, Rongrong/B-8365-2019; Li,
   Guangliang/B-6715-2011
OI Lu, Chao/0000-0002-0762-5797; 
FU Traditional Chinese Medicine Scientific Research Fund Project of
   Zhejiang Province [2022ZB058, 2022ZB183, 2023ZL019]
FX The study was supported by the Traditional Chinese Medicine Scientific
   Research Fund Project of Zhejiang Province (Grant Nos. 2022ZB058,
   2022ZB183, and 2023ZL019).
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   Areti A, 2014, REDOX BIOL, V2, P289, DOI 10.1016/j.redox.2014.01.006
   Bandos H, 2018, JNCI-J NATL CANCER I, V110, DOI 10.1093/jnci/djx162
   Bao T, 2021, ONCOLOGIST, V26, pE2070, DOI 10.1002/onco.13933
   Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Basch E, 2014, JNCI-J NATL CANCER I, V106, DOI 10.1093/jnci/dju244
   Beijers AJM, 2016, SUPPORT CARE CANCER, V24, P2411, DOI 10.1007/s00520-015-3032-y
   Boyette-Davis JA, 2018, PAIN MANAG, V8, P363, DOI 10.2217/pmt-2018-0020
   Briani C, 2014, J PERIPHER NERV SYST, V19, P299, DOI 10.1111/jns.12097
   Burgess J, 2021, ONCOL THER, V9, P385, DOI 10.1007/s40487-021-00168-y
   Cavaletti G, 2013, ANN ONCOL, V24, P454, DOI 10.1093/annonc/mds329
   Chan AW, 2013, ANN INTERN MED, V158, P200, DOI 10.7326/0003-4819-158-3-201302050-00583
   Connelly M, 2010, J PAIN, V11, P1451, DOI 10.1016/j.jpain.2010.04.011
   [崔光卫 Cui Guangwei], 2017, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V32, P2670
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Fumagalli G, 2021, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.626687
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Gradishar WJ, 2022, J NATL COMPR CANC NE, V20, P691, DOI 10.6004/jnccn.2022.0030
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   Han YJ, 2018, MINERVA ENDOCRINOL, V43, P11, DOI 10.23736/S0391-1977.16.02505-0
   Hjermstad MJ, 2011, J PAIN SYMPTOM MANAG, V41, P1073, DOI 10.1016/j.jpainsymman.2010.08.016
   Hu LY, 2019, CURR NEUROPHARMACOL, V17, P184, DOI 10.2174/1570159X15666170915143217
   Jin YX, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8875433
   Kim HY, 2014, J KOREAN ACAD NURS, V44, P735, DOI 10.4040/jkan.2014.44.6.735
   Kuang Biyao LM., 2019, TIANJIN J TRADIT CHI, V36, P673
   Leal AD, 2014, CANCER-AM CANCER SOC, V120, P1890, DOI 10.1002/cncr.28654
   Li FL, 2021, CELL DEATH DIS, V12, DOI 10.1038/s41419-021-03619-6
   Li Y., 2019, MOL PAIN, V43, P496
   Li YY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235917
   Loprinzi CL, 2020, J CLIN ONCOL, V38, DOI 10.1200/JCO.20.01399
   Ma JC, 2018, CANCER-AM CANCER SOC, V124, P2289, DOI 10.1002/cncr.31248
   Meng XZ, 2011, BRAIN RES, V1414, P58, DOI 10.1016/j.brainres.2011.08.004
   Postma TJ, 2005, EUR J CANCER, V41, P1135, DOI 10.1016/j.ejca.2005.02.012
   Qiu Tao, 2011, Zhongguo Zhen Jiu, V31, P827
   Sawangjit R, 2020, J ALTERN COMPLEM MED, V26, P1117, DOI 10.1089/acm.2020.0068
   Schröder S, 2007, EUR J NEUROL, V14, P276, DOI 10.1111/j.1468-1331.2006.01632.x
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Staff NP, 2017, ANN NEUROL, V81, P772, DOI 10.1002/ana.24951
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Xu B, 2021, ANN ONCOL, V32, P218, DOI 10.1016/j.annonc.2020.10.600
   Xu JN, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.524223
   Yokoyama S, 2022, SUPPORT CARE CANCER, V30, P1765, DOI 10.1007/s00520-021-06585-z
   Zajaczkowska R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061451
   Zhang P, 2017, LANCET ONCOL, V18, P371, DOI 10.1016/S1470-2045(17)30088-8
   Zhang P, 2016, J HEMATOL ONCOL, V9, DOI 10.1186/s13045-016-0297-7
   Zhang P, 2011, CANCER CHEMOTH PHARM, V68, P971, DOI 10.1007/s00280-011-1571-6
NR 47
TC 1
Z9 2
U1 4
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD FEB 9
PY 2023
VL 14
AR 1065635
DI 10.3389/fneur.2023.1065635
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 9E8EB
UT WOS:000937011500001
PM 36846114
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Liu, Q
   Qin, XG
   Luo, CL
   Zhao, ZT
   Xie, WJ
   Du, XZ
   Qin, X
AF Liu, Qiang
   Qin, Xiaoguang
   Luo, Chenglin
   Zhao, Zhongting
   Xie, Wangjun
   Du, Xiaozheng
   Qin, Xin
TI Effects of warm needle acupuncture on behavioral pain threshold in a rat
   model of migraine
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE needle warming acupuncture; migraine; ET-1 protein; 5-HT; CGRP
ID 5-HYDROXYTRYPTAMINE; PROPHYLAXIS; ACTIVATION
AB Background: As a traditional Chinese treatment method, acupuncture has a long history in the treatment of migraine and a rich literature base. As a traditional acupuncture technique, warm needle acupuncture has clearly demonstrated clinical efficacy in the treatment of migraine, although its mechanism of action remains unclear. This study aimed to evaluate the efficacy and safety of warm needle acupuncture in the treatment of migraine in a rat model of migraine by comparing pain threshold and analgesic-related factors among different groups. Methods: Thirty Sprague-Dawley rats were randomly divided into control, model, and acupuncture groups, with 10 animals in each group. On day 8, rat migraine models were established by subcutaneous injection of nitroglycerin. The acupuncture group was bilaterally needled once per day at Fengchi, Baihui, Fengfu, and Hegu. Behavioral changes and biochemical alterations among the rats before and after modeling were observed for 7 consecutive days after treatment. The expression of Endothelin-1 (ET-1), interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-alpha) in the brain stem of the animals were assessed using ELISA. Expression levels of calcitonin gene-related peptide (CGRP) mRNA were determined using real-time quantitative polymerase chain reaction techniques. Results: After treatment, the expression of ET-1, IL-6, TNF-alpha, and CGRP in the brain stem of the model group was significantly increased compared with that of the control group (p < 0.05), while the expression of IL-6, TNF-alpha, and CGRP in the brain stem of the acupuncture group was decreased. Conclusion: Warm needle acupuncture reduced ET-1 protein levels and promoted the expression of neurotransmitters, such as 5-hydroxytryptamine, in migraine rat model animals. In addition, needle warming acupuncture decreased IL-6, TNF-alpha, and CGRP levels in the brain stem of the migraine group, which may explain its mechanism of action in treating migraine.
C1 [Liu, Qiang; Qin, Xiaoguang; Luo, Chenglin; Zhao, Zhongting; Xie, Wangjun; Du, Xiaozheng] Gansu Univ Tradit Chinese Med, Dept Acupuncture & Moxibust, Lanzhou, Peoples R China.
   [Qin, Xin] Northwest Minzu Univ, Med Fac, Lanzhou, Peoples R China.
C3 Gansu University of Chinese Medicine; Northwest Minzu University
RP Du, XZ (corresponding author), Gansu Univ Tradit Chinese Med, Dept Acupuncture & Moxibust, Lanzhou, Peoples R China.; Qin, X (corresponding author), Northwest Minzu Univ, Med Fac, Lanzhou, Peoples R China.
EM lz-duxiaozheng@163.com; qinxin111209@163.com
FU Gansu Provincial Department of Education [2020B-52]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. Thanks Gansu Provincial
   Department of Education 2020 Innovation Ability Improvement Project: The
   regulation mechanism of PKC epsilon pathway in migraine model rats under
   the intervention of Wentong acupuncture based on the theory of pain
   sensitivity. PKC pathway regulation mechanism (2020B-52) supporting and
   promoting this research work.
CR Arzani M, 2020, J HEADACHE PAIN, V21, DOI 10.1186/s10194-020-1078-9
   Baloh RW, 2020, SEMIN NEUROL, V40, P76, DOI 10.1055/s-0039-3402735
   Chen YQ, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000023036
   Cooper W, 2020, POSTGRAD MED, V132, P581, DOI 10.1080/00325481.2020.1767402
   de Vries T, 2020, PHARMACOL THERAPEUT, V211, DOI 10.1016/j.pharmthera.2020.107528
   Deen M, 2019, CEPHALALGIA, V39, P526, DOI 10.1177/0333102418793642
   Deen M, 2018, NEUROIMAGE-CLIN, V18, P97, DOI 10.1016/j.nicl.2018.01.016
   Edvinsson L, 2019, HANDB EXP PHARMACOL, V255, P121, DOI 10.1007/164_2018_201
   Edvinsson L, 2018, NAT REV NEUROL, V14, P338, DOI 10.1038/s41582-018-0003-1
   Evers S, 1999, Paediatr Drugs, V1, P7, DOI 10.2165/00128072-199901010-00002
   FOZARD JR, 1994, N-S ARCH PHARMACOL, V350, P225
   Ha H, 2019, AM FAM PHYSICIAN, V99, P17
   Hämäläinen ML, 2006, CNS DRUGS, V20, P813
   Hougaard A, 2020, HEADACHE, V60, P724, DOI 10.1111/head.13753
   Huang YS, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000024401
   Iyengar S, 2019, HEADACHE, V59, P659, DOI 10.1111/head.13529
   Ji SZ, 2021, NEURAL PLAST, V2021, DOI 10.1155/2021/8876873
   Jo HR, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/4159172
   Ju ZY, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012057.pub2
   Li Y, 2012, CAN MED ASSOC J, V184, P401, DOI 10.1503/cmaj.110551
   Li YX, 2020, PAIN RES MANAG, V2020, DOI 10.1155/2020/3825617
   Lin SJ, 2020, J TRADIT CHIN MED, V40, P267
   Liu GF, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/6868625
   Liu L, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-020653
   Natbony LR, 2020, CURR PAIN HEADACHE R, V24, DOI 10.1007/s11916-020-00864-w
   Nye BL, 2015, HEADACHE, V55, P359, DOI 10.1111/head.12536
   Oliveira AB, 2017, NEUROIMMUNOMODULAT, V24, P293, DOI 10.1159/000487141
   Peters GL, 2019, AM J MANAG CARE, V25, pS23
   Qi J, 2014, NEURAL REGEN RES, V9, P293, DOI 10.4103/1673-5374.128227
   Redon S, 2021, REV NEUROL-FRANCE, V177, P773, DOI 10.1016/j.neurol.2021.07.002
   Silberstein SD, 2004, LANCET, V363, P381, DOI 10.1016/S0140-6736(04)15440-8
   Sugimoto K, 2020, J HEADACHE PAIN, V21, DOI 10.1186/s10194-020-01194-3
   Villalon CM, 2017, MINI-REV MED CHEM, V17, P928, DOI 10.2174/1389557516666160728121050
   Wei Y, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000023596
   Xie XY, 2020, CELL MOL BIOL, V66, P34, DOI 10.14715/cmb/2020.66.6.7
   Xue JY, 2023, J TRADIT CHIN MED, V43, P337, DOI 10.19852/j.cnki.jtcm.20221206.002
   Zhang F, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000018900
   Zhang J, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000024126
   Zhao L, 2017, JAMA INTERN MED, V177, P508, DOI 10.1001/jamainternmed.2016.9378
   Zhao ZD, 2020, ELIFE, V9, DOI 10.7554/eLife.61965
   Zhou PJ, 2015, J TRADIT CHIN MED, V35, P301
NR 41
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD OCT 1
PY 2025
VL 16
AR 1538182
DI 10.3389/fneur.2025.1538182
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 8PI2D
UT WOS:001594114100001
PM 41103513
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Öztekin, C
   Öztekin, A
AF Oztekin, Coskun
   Oztekin, Aynure
TI Global trends in acupuncture research A scientometric analysis from 1980
   to 2023
SO MEDICINE
LA English
DT Article
DE acupuncture; bibliometric analysis; citation analysis; research trends;
   scientometric analysis
ID BIBLIOMETRIC ANALYSIS; PAIN; THERAPY; MIGRAINE; CANCER
AB The objective of this study was to examine articles on acupuncture from past to present, revealing prevalent research trends, showcasing global productivity, identifying international collaborations, and highlighting influential publications and journals in the field. We acquired a comprehensive dataset comprising 9340 articles pertaining to acupuncture that were published within the time frame spanning from 1980 to 2023. These articles were sourced from the Web of Science and underwent rigorous analysis through a diverse set of bibliometric techniques. Our analytical approaches encompassed trend keyword analysis, thematic evolution analysis, conceptual structure analysis, factor analysis, citation and co-citation analyses, as well as an exploration of international collaboration patterns. The 3 most productive countries were China (n = 3357), the USA (n = 1351), and South Korea (n = 814). The 3 most productive journals were Acupuncture in Medicine (n = 440), Evidence Based Complementary and Alternative Medicine (n = 415), and Medical Acupuncture (n = 400). The 3 journals with the highest h-index on acupuncture were the Journal of Alternative and Complementary Medicine (h = 45), Pain (h = 41), and the American Journal of Chinese Medicine (h = 35). The most active author was Park Hi-Joon (n = 128). According to the findings of the factor analysis, acupuncture literature was grouped around 3 main subfactors. The primary factor encompassed topics related to the effectiveness/applicability of the treatment method for various medical conditions and general principles of acupuncture methods and points. The second factor covered topics related to mental health and quality of life. The third subfactor addressed the qualitative and quantitative analysis direction of acupuncture, such as meta-analysis and systematic reviews, and randomized controlled trials. From the past to the present, the most extensively researched main topics in acupuncture literature have covered a wide range of subjects. Prominent themes among these topics included acupuncture methods and applications, pain management, the nervous system and acupuncture, mental health and acupuncture, quality of life, and general health. In recent years, emerging trends in acupuncture research have focused on neurological health issues, oncology and cancer treatment, women's health and hormonal issues, sleep problems, digestive issues, and studies related to the quantitative and qualitative evaluation of acupuncture research.
C1 [Oztekin, Coskun] Hitit Univ, Dept Family Med, Fac Med, TR-19000 Corum, Turkiye.
   [Oztekin, Aynure] Hitit Univ, Fac Med, Dept Dermatol, TR-19040 Corum, Turkiye.
C3 Hitit University; Hitit University
RP Öztekin, A (corresponding author), Hitit Univ, Fac Med, Dept Dermatol, TR-19040 Corum, Turkiye.
EM coskunoztekin@gmail.com; aynureoztekin@gmail.com
CR Aria M, 2017, J INFORMETR, V11, P959, DOI 10.1016/j.joi.2017.08.007
   bibliometrix, Website
   Chen TY, 2021, BIOMATERIALS, V269, DOI 10.1016/j.biomaterials.2020.120608
   Chen YL, 2023, J PAIN RES, V16, P893, DOI 10.2147/JPR.S397168
   Dalamagka MI, 2023, World J. Adv. Res. Rev, V17, P556, DOI DOI 10.30574/WJARR.2023.17.2.0293
   Demir E, 2020, ALLERGOL IMMUNOPATH, V48, P374, DOI 10.1016/j.aller.2020.01.001
   Demir E, 2020, J FORENSIC LEG MED, V69, DOI 10.1016/j.jflm.2019.101885
   Ekici M, 2023, EUR REV MED PHARMACO, V27, P11947, DOI 10.26355/eurrev_202312_34794
   Fu LY, 2024, BIOTECHNOL GENET ENG, V40, P2842, DOI 10.1080/02648725.2023.2202539
   Goldman N, 2010, NAT NEUROSCI, V13, P883, DOI 10.1038/nn.2562
   Golpinar M, 2023, MINERVA PEDIATR, V75, P270, DOI 10.23736/S2724-5276.21.06278-9
   Golpinar M, 2020, J ANAT SOC INDIA, V69, P155, DOI 10.4103/JASI.JASI_114_20
   Guo YH, 2023, COMPLEMENT THER MED, V78, DOI 10.1016/j.ctim.2023.102984
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hui KKS, 2005, NEUROIMAGE, V27, P479, DOI 10.1016/j.neuroimage.2005.04.037
   Hui KKS, 2000, HUM BRAIN MAPP, V9, P13, DOI 10.1002/(SICI)1097-0193(2000)9:1<13::AID-HBM2>3.0.CO;2-F
   Hui L, 2020, CHIN J INTEGR MED, V26, P943, DOI 10.1007/s11655-020-3218-0
   Kaba İ, 2023, Medical Science and Discovery, V10, P564, DOI [10.36472/msd.v10i8.1015, DOI 10.36472/MSD.V10I8.1015]
   Kaptchuk TJ, 2002, ANN INTERN MED, V136, P374, DOI 10.7326/0003-4819-136-5-200203050-00010
   Karabulut A, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000034817
   Lee JA, 2011, BURNS, V37, P117, DOI 10.1016/j.burns.2010.07.005
   Linde K, 2005, JAMA-J AM MED ASSOC, V293, P2118, DOI 10.1001/jama.293.17.2118
   Ling FY, 2023, J PAIN RES, V16, P985, DOI 10.2147/JPR.S395421
   Lu FY, 2023, J PAIN RES, V16, P1025, DOI 10.2147/JPR.S401875
   Özkadi T, 2022, Hitit Medical Journal, V4, P39, DOI [10.52827/hititmedj.1121920, DOI 10.52827/HITITMEDJ.1121920]
   Pilkington K, 2010, AUTON NEUROSCI-BASIC, V157, P91, DOI 10.1016/j.autneu.2010.04.002
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Streitberger K, 1998, LANCET, V352, P364, DOI 10.1016/S0140-6736(97)10471-8
   Tan EK, 2009, INT J DERMATOL, V48, P648, DOI 10.1111/j.1365-4632.2009.03899.x
   van Eck NJ, 2010, SCIENTOMETRICS, V84, P523, DOI 10.1007/s11192-009-0146-3
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Witt C, 2005, LANCET, V366, P136, DOI 10.1016/S0140-6736(05)66871-7
   Yang N, 2023, ALTERN THER HEALTH M, V29, P74
   Zhang JL, 2023, EUR J MED RES, V28, DOI 10.1186/s40001-023-01253-w
   Zhang ML, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/1451342
   Zhao L, 2017, JAMA INTERN MED, V177, P508, DOI 10.1001/jamainternmed.2016.9378
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zhu DC, 2023, J PAIN RES, V16, P1647, DOI 10.2147/JPR.S409120
NR 39
TC 3
Z9 4
U1 5
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP 6
PY 2024
VL 103
IS 36
AR e39549
DI 10.1097/MD.0000000000039549
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA F2I0Q
UT WOS:001308095200111
PM 39252270
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ji, YJ
   Li, SY
   Zhang, XY
   Li, Q
   Lu, Q
   Chen, WL
   Liu, Y
   Sheng, JY
   Liang, HL
   Jiang, K
   Li, MT
   Sha, SY
   Wu, HG
   Huang, Y
   Xue, XH
AF Ji, Yajie
   Li, Siyu
   Zhang, Xinyue
   Li, Qiong
   Lu, Qing
   Chen, Weili
   Liu, Yu
   Sheng, Jiayu
   Liang, Hongli
   Jiang, Ke
   Li, Mengting
   Sha, Shanyan
   Wu, Huangan
   Huang, Yan
   Xue, Xiaohong
TI The Efficacy of Moxibustion for Breast Cancer Patients with
   Chemotherapy-Induced Myelosuppression during Adjuvant Chemotherapy: A
   Randomized Controlled Study
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID COLONY-STIMULATING FACTORS; ACUTE MYELOID-LEUKEMIA; MYELODYSPLASTIC
   SYNDROME; REGIMENS
AB Objective. The randomized controlled clinical trial aims to investigate the clinical efficacy of moxibustion for breast cancer patients with chemotherapy-induced myelosuppression (CIM) during adjuvant chemotherapy. Methods. Surgically resected breast cancer patients were randomly divided into the moxibustion group (MOX; n = 48) and control group (CON; n = 44). Routine adjuvant chemotherapy (every 21 days, 4-8 cycles) and supportive recombinant human granulocyte colony-stimulating factor were given to both groups, while MOX received an additional moxibustion treatment (once daily after each cycle of chemotherapy). Primary endpoints included the grade of myelosuppression in terms of white blood cell (W BC) and absolute neutrophil count (ANC) and the incidence of myelosuppression-related serious adverse events (SAES). Other measures included treatment compliance, adverse events (AEs), and survival. Results. WBC counts were generally higher in MOX and were dramatically higher than those in CON at the 7th course of chemotherapy (P = 0.008), while grade 1 ANC reduction was dramatically lower than that in CON at the 7th course of chemotherapy (P = 0.006). These effects were particularly significant in patients receiving anthracycline-taxane combination regimens. Moreover, MOX had fewer febrile neutropenia than CON (P = 0.051). MOX demonstrated a lower incidence of grade 3-4 myelosuppression (P < 0.05). AEs including grade 2-3 severe nausea, various kinds of pains, and vertigo occurred less frequently in MOX (P < 0.05). No difference in survival was observed between the two groups (P > 0.05). Conclusion. Moxibustion is effective for treating CIM in breast cancer patients during adjuvant chemotherapy, especially for patients receiving high-dose, long-term, and combined chemotherapy regimens. Moxibustion can reduce the incidence of myelosuppression-related SAE and improve the compliance and safety of chemotherapy in breast cancer.
C1 [Ji, Yajie; Li, Siyu; Zhang, Xinyue; Li, Qiong; Lu, Qing; Chen, Weili; Liu, Yu; Sheng, Jiayu; Liang, Hongli; Jiang, Ke; Li, Mengting; Sha, Shanyan; Xue, Xiaohong] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Chinese & Western Med, Dept Breast Surg, Shanghai 200437, Peoples R China.
   [Ji, Yajie; Wu, Huangan; Huang, Yan] Shanghai Univ Tradit Chinese Med, Shanghai Res Inst Acupuncture & Meridian, Shanghai 200030, Peoples R China.
   [Wu, Huangan; Huang, Yan] Shanghai Univ Tradit Chinese Med, Key Lab Acupuncture & Immunol Effects, Shanghai 200030, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Shanghai University of Traditional
   Chinese Medicine
RP Xue, XH (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Chinese & Western Med, Dept Breast Surg, Shanghai 200437, Peoples R China.
EM 195641459@qq.com
FU Three-Year Program of Shanghai Hospital Development Center [16CR2026B];
   National Natural Science Foundation of China [82004446]
FX This work was supported by grants from the Three-Year Program of
   Shanghai Hospital Development Center (No. 16CR2026B) and the National
   Natural Science Foundation of China (No. 82004446), as a preliminary
   study.
CR ANTMAN KS, 1988, NEW ENGL J MED, V319, P593, DOI 10.1056/NEJM198809083191001
   Baden LR, 2016, J NATL COMPR CANC NE, V14, P882, DOI 10.6004/jnccn.2016.0093
   [曹威 Cao Wei], 2018, [中华普通外科杂志, Chinese Journal of General Surgery], V33, P223, DOI 10.3760/cma.j.issn.1007-631x.2018.03.012
   Chinese Association for Clinical Oncologists The Chinese Anti-Cancer Association the Society of Chemotherapy and Editorial Committee National Medical Journal of China, 2015, NATL MED J CHINA, V95, P3001
   de Miguel SC, 2015, SUPPORT CARE CANCER, V23, P547, DOI 10.1007/s00520-014-2459-x
   Hershman D, 2007, JNCI-J NATL CANCER I, V99, P196, DOI 10.1093/jnci/djk028
   Ito Y., 2008, BREAST CANCER-TOKYO, V14, P393
   Ji Y, 2019, GUANGMING J CHIN MED, V34, P2266
   Ji YJ, 2020, TRIALS, V21, DOI 10.1186/s13063-020-04749-6
   Jiang Jin-Feng, 2013, Zhongguo Zhen Jiu, V33, P860
   Jiang ShuangFeng Jiang ShuangFeng, 2019, Journal of Guangdong Pharmaceutical University, V35, P451
   Joerger M, 2013, EXPERT REV ANTICANC, V13, P165, DOI [10.1586/era.12.172, 10.1586/ERA.12.172]
   Li C., 2012, J QIQIHAR U MED, V24, P3451
   Lidan Z, 2018, Zhongyi Linchuang Yanjiu, V10, P117
   Lin H., 2015, SHENZHEN J INTEGRATE, V8, P29
   Lu J., 2007, J PRACTICAL ONCOLOGY, V6, P527
   Lyman GH, 2010, J CLIN ONCOL, V28, P2914, DOI 10.1200/JCO.2009.25.8723
   Mamounas EP, 2001, SEMIN ONCOL, V28, P24, DOI 10.1053/sonc.2001.26432
   NCCN, 2015, NCCN CLIN PRACTICE G, V6
   Ni G., 2014, WORLD J INTEGRATED T, V9, P101
   Shen X., 2016, SCI MERIDIANS ACUPOI
   Smith TJ, 2015, J CLIN ONCOL, V33, P3199, DOI 10.1200/JCO.2015.62.3488
   Su Q., 2013, GUANGMING J CHINESE, V11, P2107
   Tian H., 2015, Clin. J. Chin. Med., V10, P35
   Wu h, 2013, MODERN RES CHINESE M
   Zhang W., 2017, Nei Mongol. J. Tradit. Chin. Med., V5, P72
   Zhang W., 2013, ASIA PACIFIC TRADITI, V11, P75
   Zhou H., 2016, CHINA J CHINESE MAT
NR 28
TC 8
Z9 13
U1 5
U2 40
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD APR 26
PY 2021
VL 2021
AR 1347342
DI 10.1155/2021/1347342
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA SK7GA
UT WOS:000656383500004
PM 33986813
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Deganello, A
   Battat, N
   Muratori, E
   Cristofaro, G
   Buongiorno, A
   Mannelli, G
   Picconi, M
   Giachetti, R
   Borsotti, G
   Gallo, O
AF Deganello, Alberto
   Battat, Nir
   Muratori, Enrico
   Cristofaro, Glauco
   Buongiorno, Ana
   Mannelli, Giuditta
   Picconi, Mario
   Giachetti, Rita
   Borsotti, Giulia
   Gallo, Oreste
TI Acupuncture in shoulder pain and functional impairment after neck
   dissection: A prospective randomized pilot study
SO LARYNGOSCOPE
LA English
DT Article
DE Acupuncture; neck dissection; neck disability; neck pain; shoulder
   syndrome; shoulder dysfunction
ID N0 LARYNGEAL-CANCER; HEALTHY-SUBJECTS; TRIAL; ANALGESIA; BRAIN
AB Objectives/HypothesisThe efficacy of conventional physiotherapy and antiinflammatory/analgesic drugs in the management of shoulder pain and functional disability following neck dissection is often disappointing. Acupuncture is a safe and well-tolerated method. We report the results regarding our pilot trial of acupuncture versus conventional care in the management of postoperative shoulder pain and dysfunction after neck dissection.
   Study DesignPilot study.
   MethodsPatients at a tertiary university center with chronic pain or dysfunction attributed to neck dissection were randomly assigned to either weekly acupuncture or usual care (eg., physical therapy, analgesia, and/or antiinflammatory drugs) for 5 consecutive weeks. The Constant-Murley score, a composite measure of pain, function, and activities of daily living, was the primary outcome measure. As secondary end point, The Neck Dissection Impairment Index (NDII) was used to quantify site-specific, self-reported quality of life (QOL).
   ResultsAfter randomization, 48 patients completed the study (23 and 25 patients on acupuncture and control arms, respectively). Constant-Murley scores improved more in the acupuncture group (gain difference between groups 13.6, P < 0.01), a statistically significant improvement in site-specific QOL was also recorded at NDII (gain difference between groups 11.5, P < 0.01).
   ConclusionAcupuncture is safe and effective; it should be introduced and offered to patients suffering from neck pain and dysfunction related to neck dissection.
C1 [Deganello, Alberto; Battat, Nir; Muratori, Enrico; Cristofaro, Glauco; Buongiorno, Ana; Mannelli, Giuditta; Gallo, Oreste] Univ Florence, Clin Otolaryngol Head & Neck Surg 1, Dept Surg & Translat Med, Largo Brambilla 3, I-50134 Florence, Italy.
   [Giachetti, Rita; Borsotti, Giulia] Univ Florence, Dept Anaesthesiol, Florence, Italy.
   [Picconi, Mario] Sinergie Ctr, Acupuncture, Florence, Italy.
C3 University of Florence; University of Florence
RP Deganello, A (corresponding author), Univ Florence, Clin Otolaryngol Head & Neck Surg 1, Dept Surg & Translat Med, Largo Brambilla 3, I-50134 Florence, Italy.
EM adeganello@hotmail.com
RI ; DEGANELLO, ALBERTO/I-2742-2014
OI Mannelli, Giuditta/0000-0001-7079-3964; Gallo,
   Oreste/0000-0003-3426-7179; DEGANELLO, ALBERTO/0000-0003-1008-7333
CR Cappiello Johnny, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P107, DOI 10.1097/MOO.0b013e3280523ac5
   Ceccherelli F, 2001, ACUPUNCTURE ELECTRO, V26, P229, DOI 10.3727/036012901816355938
   Dawidson I, 1998, LIFE SCI, V63, P659, DOI 10.1016/S0024-3205(98)00317-8
   Deganello A, 2014, J LARYNGOL OTOL, V128, P1089, DOI 10.1017/S0022215114002709
   Deganello A, 2011, ACTA OTORHINOLARYNGO, V31, P216
   Dhond RP, 2008, PAIN, V136, P407, DOI 10.1016/j.pain.2008.01.011
   Dijkstra PU, 2001, HEAD NECK-J SCI SPEC, V23, P947, DOI 10.1002/hed.1137
   Fiorini FR, AM J OTOLARYNGOL, V201, P484
   Gallo O, 2006, Acta Otorhinolaryngol Ital, V26, P335
   HAN JS, 1982, ANNU REV PHARMACOL, V22, P193, DOI 10.1146/annurev.pa.22.040182.001205
   Hui KKS, 2000, HUM BRAIN MAPP, V9, P13, DOI 10.1002/(SICI)1097-0193(2000)9:1<13::AID-HBM2>3.0.CO;2-F
   Irnich D, 2002, PAIN, V99, P83, DOI 10.1016/S0304-3959(02)00062-3
   Irnich D, 2001, BMJ-BRIT MED J, V322, P1574, DOI 10.1136/bmj.322.7302.1574
   Kleinhenz J, 1999, PAIN, V83, P235, DOI 10.1016/S0304-3959(99)00107-4
   McNeely ML, 2008, CANCER, V113, P214, DOI 10.1002/cncr.23536
   Murley AH, 1987, CLIN ORTHOP RELAT R, V214, P160
   NAHUM AM, 1961, ARCHIV OTOLARYNGOL, V74, P424
   O'Connor DA, 1999, ARTHROSCOPY, V15, P836, DOI 10.1053/ar.1999.v15.015083
   Pariente J, 2005, NEUROIMAGE, V25, P1161, DOI 10.1016/j.neuroimage.2005.01.016
   Pfister DG, 2010, J CLIN ONCOL, V28, P2565, DOI 10.1200/JCO.2009.26.9860
   Sandberg M, 2003, EUR J APPL PHYSIOL, V90, P114, DOI 10.1007/s00421-003-0825-3
   Sandkühler J, 2000, PAIN, V88, P113, DOI 10.1016/S0304-3959(00)00424-3
   Sarno A, 2004, ACTA OTO-LARYNGOL, V124, P980, DOI 10.1080/00016480410017341
   Skutek M, 2000, ARCH ORTHOP TRAUM SU, V120, P432, DOI 10.1007/s004020000133
   Staud R, 2006, EXPERT REV NEUROTHER, V6, P661, DOI 10.1586/14737175.6.5.661
   Sun K. O., 2001, Hong Kong Medical Journal, V7, P381
   Taylor RJ, 2002, ARCH OTOLARYNGOL, V128, P44, DOI 10.1001/archotol.128.1.44
   Vickers A, 2001, BRIT MED J, V323, P1306, DOI 10.1136/bmj.323.7324.1306
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
NR 29
TC 14
Z9 20
U1 0
U2 33
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD AUG
PY 2016
VL 126
IS 8
BP 1790
EP 1795
DI 10.1002/lary.25921
PG 6
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA DR6AY
UT WOS:000379984700017
PM 27010596
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Kawasaki, N
   Ishiki, H
   Matsubara, N
   Ikegami, T
   Ishikawa, A
   Nishimura, R
   Arakawa, S
   Uchida, T
   Nameki, Y
   Takahashi, A
   Horiguchi, Y
   Ogawa, A
   Watase, C
   Murata, T
   Shiino, S
   Takayama, S
   Suto, A
   Matsuoka, H
   Satomi, E
AF Kawasaki, N.
   Ishiki, H.
   Matsubara, N.
   Ikegami, T.
   Ishikawa, A.
   Nishimura, R.
   Arakawa, S.
   Uchida, T.
   Nameki, Y.
   Takahashi, A.
   Horiguchi, Y.
   Ogawa, A.
   Watase, C.
   Murata, T.
   Shiino, S.
   Takayama, S.
   Suto, A.
   Matsuoka, H.
   Satomi, E.
TI The safety and efficacy of acupuncture in breast cancer survivors with
   post-mastectomy pain syndrome, a single-arm exploratory study (ABC-1
   study)
SO ANNALS OF ONCOLOGY
LA English
DT Meeting Abstract
CT European-Society-for-Medical-Oncology Asia Congress (ESMO)
CY DEC 06-08, 2024
CL Singapore, SINGAPORE
SP European Soc Med Oncol
C1 [Kawasaki, N.; Ishiki, H.; Matsubara, N.; Ikegami, T.; Ishikawa, A.; Nishimura, R.; Arakawa, S.; Uchida, T.; Nameki, Y.; Takahashi, A.; Horiguchi, Y.; Satomi, E.] Natl Canc Ctr, Dept Palliat Med, Tokyo, Japan.
   [Ogawa, A.; Watase, C.; Murata, T.; Shiino, S.; Takayama, S.; Suto, A.] Natl Canc Ctr, Dept Breast Surg, Tokyo, Japan.
   [Matsuoka, H.] Natl Canc Ctr, Dept Psychooncol, Tokyo, Japan.
C3 National Cancer Center - Japan; National Cancer Center - Japan; National
   Cancer Center - Japan
RI Hiroto, Ishiki/AHC-0321-2022; Takayama, Shin/ABE-1802-2020
NR 0
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0923-7534
EI 1569-8041
J9 ANN ONCOL
JI Ann. Oncol.
PD DEC
PY 2024
VL 35
SU 4
MA 592TiP
BP S1615
EP S1615
DI 10.1016/j.annonc.2024.10.618
EA DEC 2024
PG 1
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology
GA T0J8N
UT WOS:001401985200378
OA Bronze
DA 2026-01-16
ER

PT J
AU Diller, ML
   Master, VA
AF Diller, Maggie L.
   Master, Viraj A.
TI Integrative surgical oncology: A model of acute integrative oncology
SO CANCER
LA English
DT Review
DE acute integrative oncology; complementary medicine; integrative surgery;
   integrative surgical oncology
ID CHEMOTHERAPY-INDUCED NAUSEA; CANCER-RELATED FATIGUE; POSTOPERATIVE PAIN;
   PREOPERATIVE ANXIETY; P6 ACUSTIMULATION; MUSIC INTERVENTIONS;
   RISK-FACTORS; ACUPUNCTURE; ACUPRESSURE; HYPNOSIS
AB Integrative oncology has emerged as a recognized medical subspecialty because of growing interest in the use of integrative medicine in modern cancer care on behalf of both patients and providers. Acutherapy and mind-body techniques, such as meditation and yoga, have been shown to aid in symptom control and improve quality of life in oncologic patient populations, and the Society of Integrative Oncology and American Society of Clinical Oncology have recently endorsed a set of guidelines for the implementation of these techniques specifically in patients with breast cancer. Although the current guidelines focus largely on the management of chronic symptoms, there exists evidence to support the use of these techniques in acute symptom management as well. With surgical resection representing the backbone of many cancer treatment regimens, symptoms that arise during the perioperative period are prime examples of the acute symptomatology common among patients with cancer. Here, the authors provide a detailed literature review of the current evidence supporting the use of integrative techniques during the perioperative period and demonstrate their applicability for acute symptom management within oncologic and surgical populations. In doing so, the authors introduce a new paradigm of surgical practice they call integrative surgical oncology and integrative surgery.
C1 [Diller, Maggie L.] Emory Univ, Dept Surg, Atlanta, GA 30322 USA.
   [Diller, Maggie L.; Master, Viraj A.] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA.
   [Master, Viraj A.] Emory Univ, Dept Urol, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University
RP Master, VA (corresponding author), Emory Univ, Sch Med, 1365 Clifton Rd, Atlanta, GA 30322 USA.
EM vmaster@emory.edu
CR Apfelbaum JL, 2003, ANESTH ANALG, V97, P534, DOI 10.1213/01.ANE.0000068822.10113.9E
   Awaludin S., 2020, ADV HLTH SCI RES, V20, P276
   Bhavanani Ananda Balayogi, 2011, Int J Yoga Therap, P73
   Bidgoli MM, 2016, J CARDIOVASC THORAC, V8, P170, DOI 10.15171/jcvtr.2016.34
   Cao Zhiliang, 2017, Zhongguo Zhen Jiu, V37, P247, DOI 10.13703/j.0255-2930.2017.03.007
   Chandrababu R, 2019, CLIN EPIDEMIOL GLOB, V7, P606, DOI 10.1016/j.cegh.2019.01.009
   Chang QY, 2002, ACUPUNCTURE ELECTRO, V27, P191, DOI 10.3727/036012902816025951
   Chen KW, 2012, DEPRESS ANXIETY, V29, P545, DOI 10.1002/da.21964
   Chlan L, 2000, Gastroenterol Nurs, V23, P148, DOI 10.1097/00001610-200007000-00003
   Cramer H, 2014, INT J CARDIOL, V173, P170, DOI 10.1016/j.ijcard.2014.02.017
   DeLoach Walworth Darcy, 2005, J Pediatr Nurs, V20, P276
   Deng Gary E, 2009, J Soc Integr Oncol, V7, P85
   Di Iulio A, 2020, Journal of Advanced Health Care, P21, DOI 10.36017/jahc2001-002
   El-Deeb AM, 2011, J ANESTH, V25, P698, DOI 10.1007/s00540-011-1198-0
   Ertas G, 2015, HOLIST NURS PRACT, V29, P6, DOI 10.1097/HNP.0000000000000061
   Escobar Y, 2015, SUPPORT CARE CANCER, V23, P2833, DOI 10.1007/s00520-015-2809-3
   Everdingen MHJVDBV, 2007, ANN ONCOL, V18, P1437, DOI 10.1093/annonc/mdm056
   Flory N, 2007, INT J CLIN EXP HYP, V55, P303, DOI 10.1080/00207140701338670
   Frey UH, 2009, ACTA ANAESTH SCAND, V53, P1341, DOI 10.1111/j.1399-6576.2009.02081.x
   Frey UH, 2009, BRIT J ANAESTH, V102, P620, DOI 10.1093/bja/aep014
   Gan TJ, 2014, CURR MED RES OPIN, V30, P149, DOI 10.1185/03007995.2013.860019
   Garland EL, 2017, J GEN INTERN MED, V32, P1106, DOI 10.1007/s11606-017-4116-9
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hole J, 2015, LANCET, V386, P1659, DOI 10.1016/S0140-6736(15)60169-6
   Horneber M, 2012, INTEGR CANCER THER, V11, P187, DOI 10.1177/1534735411423920
   Jung BF, 2003, PAIN, V104, P1, DOI 10.1016/S0304-3959(03)00241-0
   Kabat-Zin Jon., 1990, FULL CATASTROPHE LIV
   Kane E.O., 1914, Journal of the American Medical Association, V57, P1829, DOI DOI 10.1001/JAMA.1914.02560480063031
   Kane-Gill Sandra L, 2014, J Pain Palliat Care Pharmacother, V28, P282, DOI 10.3109/15360288.2014.938889
   Katz J, 2005, PAIN, V119, P16, DOI 10.1016/j.pain.2005.09.008
   Kim KH, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-013457
   Kim KS, 2006, ANESTH ANALG, V103, P709, DOI 10.1213/01.ane.0000228864.74691.9f
   Kotani N, 2001, ANESTHESIOLOGY, V95, P349, DOI 10.1097/00000542-200108000-00015
   Kühlmann AYR, 2018, BJS-BRIT J SURG, V105, P773, DOI 10.1002/bjs.10853
   Lam WL, 2018, TRIALS, V19, DOI 10.1186/s13063-017-2359-8
   Lang EV, 2002, RADIOLOGY, V222, P375, DOI 10.1148/radiol.2222010528
   Lee A, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003281.pub4
   Lew MW, 2011, INT J CLIN EXP HYP, V59, P406, DOI 10.1080/00207144.2011.594737
   Ling WM, 2014, ONCOL NURS FORUM, V41, P581, DOI 10.1188/14.ONF.581-592
   Liu YH, 2017, AM J CHINESE MED, V45, P1127, DOI 10.1142/S0192415X17500616
   Lopez G, 2017, MED CLIN N AM, V101, P977, DOI 10.1016/j.mcna.2017.04.011
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Maraghi E., 2020, PAK J MED HLTH SCI, V14, P1260
   Maranets I, 1999, ANESTH ANALG, V89, P1346, DOI 10.1097/00000539-199912000-00003
   Mehling WE, 2007, J PAIN SYMPTOM MANAG, V33, P258, DOI 10.1016/j.jpainsymman.2006.09.016
   Miao J, 2017, INT J NURS STUD, V70, P27, DOI 10.1016/j.ijnurstu.2017.02.014
   Molassiotis A, 2013, HEALTH TECHNOL ASSES, V17, DOI 10.3310/hta17260
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P228, DOI 10.1016/j.ctim.2006.09.009
   Montgomery GH, 2002, ANESTH ANALG, V94, P1639, DOI 10.1097/00000539-200206000-00052
   Nair DC., 2020, Amrita J Med, V16, P6, DOI [10.4103/AMJM.AMJM120, DOI 10.4103/AMJM.AMJM120]
   Parker PA, 2009, J CLIN ONCOL, V27, P3169, DOI 10.1200/JCO.2007.16.0036
   Pérez F, 2006, J TELEMED TELECARE, V12, P41, DOI 10.1258/135763306777978506
   Pitman A, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k1415
   Ralston-Wilson J, 2016, J ALTERN COMPLEM MED, V22, P458, DOI 10.1089/acm.2015.0347
   Rudin D, 2007, ENDOSCOPY, V39, P507, DOI 10.1055/s-2007-966362
   Saadat H, 2006, ANESTH ANALG, V102, P1394, DOI 10.1213/01.ane.0000204355.36015.54
   Sadhasivam S, 1999, ANESTH ANALG, V89, P1340, DOI 10.1097/00000539-199912000-00002
   Shires A, 2020, PAIN, V161, P1698, DOI 10.1097/j.pain.0000000000001877
   Soo MS, 2016, J AM COLL RADIOL, V13, P526, DOI 10.1016/j.jacr.2015.12.004
   Speca M, 2000, PSYCHOSOM MED, V62, P613, DOI 10.1097/00006842-200009000-00004
   STEVENS PE, 1995, PAIN, V61, P61, DOI 10.1016/0304-3959(94)00162-8
   Sun Y, 2008, BRIT J ANAESTH, V101, P151, DOI 10.1093/bja/aen146
   The Joint Commission, 2017, JOINT COMMISSION PER, V37, P1
   Turankar AV, 2013, INDIAN J MED RES, V137, P916
   Ugras GA, 2018, COMPLEMENT THER CLIN, V31, P158, DOI 10.1016/j.ctcp.2018.02.012
   Usichenko TI, 2005, PAIN, V114, P320, DOI 10.1016/j.pain.2004.08.021
   Valentine KE, 2019, INT J CLIN EXP HYP, V67, P336, DOI 10.1080/00207144.2019.1613863
   Vaughn Felicia, 2007, AORN J, V85, P589, DOI 10.1016/S0001-2092(07)60130-6
   Watkins AA, 2014, J AM COLL SURGEONS, V219, P511, DOI 10.1016/j.jamcollsurg.2014.03.057
   Williams C, 2018, COMPLEMENT THER MED, V37, P110, DOI 10.1016/j.ctim.2018.02.002
   Zhong Q, 2019, CHIN J INTEGR MED, V25, P225, DOI 10.1007/s11655-019-3063-1
NR 72
TC 1
Z9 1
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD NOV 1
PY 2021
VL 127
IS 21
BP 3929
EP 3938
DI 10.1002/cncr.33688
EA AUG 2021
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA WG1XH
UT WOS:000685803300001
PM 34407223
OA Bronze
DA 2026-01-16
ER

PT J
AU Hurlow, A
   Bennett, MI
   Robb, KA
   Johnson, MI
   Simpson, KH
   Oxberry, SG
AF Hurlow, Adam
   Bennett, Michael I.
   Robb, Karen A.
   Johnson, Mark I.
   Simpson, Karen H.
   Oxberry, Stephen G.
TI Transcutaneous electric nerve stimulation (TENS) for cancer pain in
   adults
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Pain Management; Neoplasms [complications]; Pain [etiology]; Randomized
   Controlled Trials as Topic; Transcutaneous Electric Nerve Stimulation
   [methods]; Adult; Humans
ID MANAGEMENT; MEDICINE; LASER
AB Background
   Cancer-related pain is complex and multi-dimensional but the mainstay of cancer pain management has predominantly used a biomedical approach. There is a need for non-pharmacological and innovative approaches. Transcutaneous Electric Nerve Stimulation (TENS) may have a role in pain management but the effectiveness of TENS is currently unknown. This is an update of the original review published in Issue 3, 2008.
   Objectives
   The aim of this systematic review was to determine the effectiveness of TENS for cancer-related pain in adults.
   Search methods
   The initial review searched The Cochrane Library, MEDLINE, EMBASE, CINAHL, PsychINFO, AMED and PEDRO databases in April 2008. We performed an updated search of CENTRAL, MEDLINE, EMBASE, CINAHL and PEDRO databases in November 2011.
   Selection criteria
   We included only randomised controlled trials (RCTS) investigating the use of TENS for the management of cancer-related pain in adults.
   Data collection and analysis
   The search strategy identified a further two studies for possible inclusion. One of the review authors screened each abstract using a study eligibility tool. Where eligibility could not be determined, a second author assessed the full paper. One author used a standardised data extraction sheet to collect information on the studies and independently assess the quality of the studies using the validated five-point Oxford Quality Scale. The small sample sizes and differences in patient study populations of the three included studies (two from the original review and a third included in this update) prevented meta-analysis. For the original review the search strategy identified 37 possible published studies; we divided these between two pairs of review authors who decided on study selection; all four review authors discussed and agreed final scores.
   Main results
   Only one additional RCT met the eligibility criteria (24 participants) for this updated review. Although this was a feasibility study, not designed to investigate intervention effect, it suggested that TENS may improve bone pain on movement in a cancer population. The initial review identified two RCTs (64 participants) therefore this review now includes a total of three RCTs (88 participants). These studies were heterogenous with respect to study population, sample size, study design, methodological quality, mode of TENS, treatment duration, method of administration and outcome measures used. In one RCT, there were no significant differences between TENS and placebo in women with chronic pain secondary to breast cancer treatment. In the other RCT, there were no significant differences between acupuncture-type TENS and sham in palliative care patients; this study was underpowered.
   Authors' conclusions
   Despite the one additional RCT, the results of this updated systematic review remain inconclusive due to a lack of suitable RCTs. Large multi-centre RCTs are required to assess the value of TENS in the management of cancer-related pain in adults.
C1 [Hurlow, Adam] Leeds Teaching Hosp NHS Trust, Palliat Care Team, Leeds, W Yorkshire, England.
   [Bennett, Michael I.] Univ Leeds, Leeds Inst Hlth Sci, Leeds, W Yorkshire, England.
   [Robb, Karen A.] Barts Hosp, Physiotherapy Dept, London, England.
   [Johnson, Mark I.] Leeds Metropolitan Univ, Fac Hlth & Social Sci, Leeds LS1 3HE, W Yorkshire, England.
   [Simpson, Karen H.] Leeds Teaching Hosp NHS Trust, Chron Pain Team, Leeds, W Yorkshire, England.
   [Oxberry, Stephen G.] Kirkwood Hosp, Huddersfield, W Yorkshire, England.
C3 University of Leeds; University of Leeds; Leeds Beckett University;
   University of Leeds
RP Hurlow, A (corresponding author), Leeds Teaching Hosp NHS Trust, Palliat Care Team, Leeds, W Yorkshire, England.
EM adamhurlow@yahoo.co.uk
RI Bennett, Michael/A-1620-2009
OI Bennett, Michael/0000-0002-8369-8349
FU Cochrane Pain, Palliative and Supportive Care; Barts; Tower Hamlets PCT,
   UK; London NHS Trust
FX We would like to acknowledge the work of: Sheila Leadbeater, Senior NHS
   Librarian in the Leeds General Infirmary in developing our search
   strategy; Jessica Thomas, Cochrane Pain, Palliative and Supportive Care
   Managing Editor for her ongoing support; and Phil Wiffen, former
   Co-ordinating Editor of the Cochrane Pain, Palliative and Supportive
   Care Review Group for his feedback on the protocol.Internal sourcesBarts
   and the London NHS Trust and Tower Hamlets PCT, UK.
CR [Anonymous], ORTHOP PHYS THER PRA
   AVELLANOSA AM, 1982, J MED, V13, P203
   Bennett MI, 2010, J PAIN, V11, P351, DOI 10.1016/j.jpain.2009.08.002
   BILD E, 1990, Revista Medico-Chirurgicala Societatii di Medici si Naturalisti din Iasi, V94, P407
   Bjordal JM, 2003, EUR J PAIN, V7, P181, DOI 10.1016/S1090-3801(02)00098-8
   Bonakdar R, 2004, PATIENT CARE NU 0909, P9
   Brosseau L, 2003, Cochrane Database Syst Rev, pCD004377
   Cata JP, 2004, J PAIN SYMPTOM MANAG, V27, P72, DOI 10.1016/j.jpainsymman.2003.05.007
   COOPERMAN AM, 1975, SURG FORUM, V26, P77
   CROMPTON AC, 1992, BRIT J OBSTET GYNAEC, V99, P492, DOI 10.1111/j.1471-0528.1992.tb13788.x
   De Pinto Mario, 2006, Anesthesiol Clin, V24, P19, DOI 10.1016/j.atc.2005.12.006
   DeSantana Josimari M, 2008, Curr Rheumatol Rep, V10, P492
   DILDIN AS, 1985, VOP ONKOL+, V31, P33
   Dowswell T, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007214.pub2
   Evtiukhin A I, 1998, Vopr Onkol, V44, P229
   Filshie J, 2000, CANC PAIN MANAGEMENT
   Gadsby J.G., 1997, Complementary Ther Med, V5, P13, DOI [10.1016/S0965-2299(97)80084-2, DOI 10.1016/S0965-2299(97)80084-2]
   Hakl L, 1989, DTSCH Z AKUPUNK, V32, P10
   Hamza MA, 1999, ANESTHESIOLOGY, V91, P1232, DOI 10.1097/00000542-199911000-00012
   Hasun R, 1988, SCHMERZ PAIN DOULEUR, V9, P234
   Hidderley Margaret, 1997, Int J Palliat Nurs, V3, P185, DOI 10.12968/ijpn.1997.3.4.185
   Jadad AR, 1996, CONTROL CLIN TRIALS, V17, P1, DOI 10.1016/0197-2456(95)00134-4
   Johnson M, 2008, CANC PAIN, V2nd
   Johnson MI, 2011, EXPERT REV NEUROTHER, V11, P735, DOI [10.1586/ern.11.48, 10.1586/ERN.11.48]
   Johnson MI, 2001, PAIN REV, V8, P121, DOI 10.1191/0968130201pr182ra
   Johnson MI., 2008, ELECTROTHERAPY EVIDE, V12th
   Jones I, 2009, BJA EDUC, V9, P130, DOI 10.1093/bjaceaccp/mkp021
   Khadilkar A, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003008.pub3
   Kim PS, 2005, SEMIN ONCOL, V32, P194, DOI 10.1053/j.seminoncol.2005.01.001
   Kroeling P, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004251.pub4
   LAMER TJ, 1994, MAYO CLIN PROC, V69, P473, DOI 10.1016/S0025-6196(12)61647-4
   Lange A, 1995, KRANKENGYMNASTIQUE, V47, P338
   Librach SL, 1988, PALLIATIVE MED, V2, P15
   LONG DM, 1991, STEREOT FUNCT NEUROS, V56, P2, DOI 10.1159/000099388
   McCaffery M, 1992, Hosp J, V8, P121
   MELZACK R, 1965, SCIENCE, V150, P971, DOI 10.1126/science.150.3699.971
   Miguel R, 2000, Cancer Control, V7, P149
   Mulvey MR, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007264.pub2
   NAVEAU S, 1992, GASTROEN CLIN BIOL, V16, P8
   Nnoaham KE, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003222.pub2
   Oosterwijk RFA, 1994, CRITICAL REV PHYS RE, V6, P219
   OSTROWSKI MJ, 1979, BRIT J CLIN PRACT, V33, P157
   Pan CX, 2000, J PAIN SYMPTOM MANAG, V20, P374, DOI 10.1016/S0885-3924(00)00190-1
   Patt R B, 1990, Am J Hosp Palliat Care, V7, P30, DOI 10.1177/104990919000700608
   Patt R B, 1992, Am J Hosp Palliat Care, V9, P41, DOI 10.1177/104990919200900604
   Picaza J A, 1975, Surg Neurol, V4, P105
   Proctor M., 1996, Cochrane Database Syst Rev, DOI [10.1002/14651858.CD002123, DOI 10.1002/14651858.CD002123]
   Rafter J, 1986, TENS CANC PAIN
   Raphael J, 2010, PAIN MED, V11, P872, DOI 10.1111/j.1526-4637.2010.00841.x
   Reeve J, 1996, INT J TECHNOL ASSESS, V12, P299, DOI 10.1017/S026646230000965X
   Reuss R, 1985, PHYS THERAPY CLIN MA, V5, P26
   Robb K, 2003, CHARTERED SOC PHYSIO, P125
   Robb KA, 2004, PPA NEWS, V17, P26
   Robb KA, 2007, J PAIN SYMPTOM MANAG, V33, P410, DOI 10.1016/j.jpainsymman.2006.09.020
   Rutjes AWS, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002823.pub2
   Rutkowski B, 1980, Pol Tyg Lek, V35, P1865
   Sang CN, 2003, J PAIN SYMPTOM MANAG, V25, P64, DOI 10.1016/S0885-3924(02)00541-9
   Searle RD, 2008, PALLIATIVE MED, V22, P878, DOI 10.1177/0269216308096719
   Sharp SM, 2003, RES PRACTITIONER, V4, P134
   Sima L, 2009, J CLIN ONCOL, V27
   Simpson K, 2000, CANC PAIN MANAGEMENT, V1
   Sloan Paul A, 2004, J Support Oncol, V2, P491
   Tonkin J, 1998, PHYSIOTHERAPY FRONTL, V4, P18
   Turk DC, 1998, PAIN, V74, P247, DOI 10.1016/S0304-3959(97)00187-5
   Urba SG, 1996, CLIN GERIATR MED, V12, P301
   Ventafridda V, 1979, ADV PAIN RES THER, V2, P509
   Walsh DM, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006142.pub2
   Walsh DM., 1997, TENS CLIN APPL RELAT
   Weinstein SM, 1994, PHYS MED REHABIL, V8, P279
   WEN HL, 1977, MOD MED ASIA, V13, P12
NR 70
TC 99
Z9 117
U1 1
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2012
IS 3
AR CD006276
DI 10.1002/14651858.CD006276.pub3
PG 29
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 908QQ
UT WOS:000301505600060
PM 22419313
OA Bronze
DA 2026-01-16
ER

PT J
AU Ginex, PK
   Hanson, BJ
   LeFebvre, KB
   Lin, YF
   Moriarty, KA
   Maloney, C
   Vrabel, M
   Morgan, RL
AF Ginex, Pamela K.
   Hanson, Brian J.
   LeFebvre, Kristine B.
   Lin, Yufen
   Moriarty, Kerri A.
   Maloney, Christine
   Vrabel, Mark
   Morgan, Rebecca L.
TI Management of Opioid-Induced and Non-Opioid-Related Constipation in
   Patients With Cancer: Systematic Review and Meta-Analysis
SO ONCOLOGY NURSING FORUM
LA English
DT Review
DE constipation; symptom management; opioid-induced constipation; cancer;
   opioids
ID CHRONIC IDIOPATHIC CONSTIPATION; RANDOMIZED PHASE-III; DOUBLE-BLIND;
   SUBCUTANEOUS METHYLNALTREXONE; ORAL METHYLNALTREXONE; NONCANCER PAIN;
   PARALLEL-GROUP; EFFICACY; PLACEBO; CHEMOTHERAPY
AB PROBLEM IDENTIFICATION: A systematic review and meta-analysis was conducted to inform the development of national clinical practice guidelines on the management of cancer constipation.
   LITERATURE SEARCH: PubMed(R), Wiley Cochrane Library, and CINAHL(R) were searched for studies published from May 2009 to May 2019.
   DATA EVALUATION: Two investigators independently reviewed and extracted data from eligible studies. The Cochrane Collaboration risk-of-bias tool was used, and the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach was used to assess the certainty of the evidence.
   SYNTHESIS: For patients with cancer and opioid-induced constipation, moderate benefit was found for osmotic or stimulant laxatives; small benefit was found for methylnaltrexone, naldemedine, and electroacupuncture. For patients with cancer and non-opioid-related constipation, moderate benefit was found for naloxegol, prucalopride, lubiprostone, and linaclotide; trivial benefit was found for acupuncture.
   IMPLICATIONS FOR PRACTICE: Effective strategies for managing opioid-induced and non-opioid-related constipation in patients with cancer include lifestyle, pharmacologic, and complementary approaches.
C1 [Ginex, Pamela K.; LeFebvre, Kristine B.; Moriarty, Kerri A.; Maloney, Christine; Vrabel, Mark] Oncol Nursing Soc, Pittsburgh, PA 15275 USA.
   [Hanson, Brian J.] Univ Minnesota, Vet Affairs Healthcare, Minneapolis, MN USA.
   [Lin, Yufen] Duke Univ, Sch Nursing, Durham, NC USA.
   [Morgan, Rebecca L.] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Duke University; McMaster University
RP Ginex, PK (corresponding author), Oncol Nursing Soc, Pittsburgh, PA 15275 USA.
EM pginex@ons.org
RI ; Vrabel, Mark/AAC-8189-2019; Hanson, Brian/AFI-8260-2022; Lin,
   Yufen/JOJ-6428-2023; Maloney, Christine/AAX-8675-2021
OI Morgan, Rebecca/0000-0002-1012-4897; Vrabel, Mark/0000-0001-7371-4483;
   Lin, Yufen/0000-0002-9182-2928; 
FU Oncology Nursing Society
FX Development of this review was wholly funded by the Oncology Nursing
   Society, a nonprofit organization that represents oncology nurses. No
   honoraria were provided. Mention of specific products and opinions
   related to those products do not indicate or imply
   endorsementbytheOncologyNursingSociety.
CR Amankwah J, 2015, ONCOL NURS FORUM, V42, pE117
   Benyamin R, 2008, PAIN PHYSICIAN, V11, pS105
   Bharucha AE, 2013, GASTROENTEROLOGY, V144, P211, DOI 10.1053/j.gastro.2012.10.029
   Bull J., 2015, FIXED DOSE SUBCUTANE, V18, P593, DOI [10.1089/jpm.2014.0362, DOI 10.1089/JPM.2014-036]
   Camilleri M, 2014, NEUROGASTROENT MOTIL, V26, P1386, DOI 10.1111/nmo.12417
   Chey WD, 2014, NEW ENGL J MED, V370, P2387, DOI 10.1056/NEJMoa1310246
   Clemens KE, 2013, CURR OPIN SUPPORT PA, V7, P183, DOI 10.1097/SPC.0b013e32835f1e17
   Costilla VC, 2014, CLIN GERIATR MED, V30, P107, DOI 10.1016/j.cger.2013.10.001
   Cryer B, 2014, PAIN MED, V15, P1825, DOI 10.1111/pme.12437
   Da NL, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/670963
   Davies A, 2020, SUPPORT CARE CANCER, V28, P23, DOI 10.1007/s00520-019-05016-4
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   Downing GM, 2007, J PAIN SYMPTOM MANAG, V34, P513, DOI 10.1016/j.jpainsymman.2007.01.014
   Ford AC, 2011, GUT, V60, P209, DOI 10.1136/gut.2010.227132
   Forootan M, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000010631
   Freedman MD, 1997, J CLIN PHARMACOL, V37, P904, DOI 10.1002/j.1552-4604.1997.tb04264.x
   Gaertner J, 2015, J CLIN GASTROENTEROL, V49, P9, DOI 10.1097/MCG.0000000000000246
   Guyatt GH, 2011, J CLIN EPIDEMIOL, V64, P1311, DOI [10.1016/j.jclinepi.2011.06.004, 10.1016/j.jclinepi.2011.03.017]
   Hale M, 2017, LANCET GASTROENTEROL, V2, P555, DOI 10.1016/S2468-1253(17)30105-X
   Hanai A, 2016, BREAST CANCER RES TR, V155, P99, DOI 10.1007/s10549-015-3652-4
   Hanson B, 2019, GASTROENTEROLOGY, V156, P229, DOI 10.1053/j.gastro.2018.08.018
   Higgins Julian P T, 2011, BMJ, V343, pd5928, DOI 10.1136/bmj.d5928
   Jamal MM, 2015, AM J GASTROENTEROL, V110, P725, DOI 10.1038/ajg.2015.106
   Katakami N, 2018, ANN ONCOL, V29, P1461, DOI 10.1093/annonc/mdy118
   Katakami N, 2017, J CLIN ONCOL, V35, P3859, DOI 10.1200/JCO.2017.73.0853
   Katakami N, 2017, J CLIN ONCOL, V35, P1921, DOI 10.1200/JCO.2016.70.8453
   Kaur V, 2017, J ONCOL PRACT, V13, pE91, DOI 10.1200/JOP.2016.013797
   Lacy BE, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134349
   Larkin PJ, 2018, ANN ONCOL, V29, P111, DOI 10.1093/annonc/mdy148
   Lee HY, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2243-4
   Lembo AJ, 2011, NEW ENGL J MED, V365, P527, DOI 10.1056/NEJMoa1010863
   Lembo AJ, 2010, GASTROENTEROLOGY, V138, P886, DOI 10.1053/j.gastro.2009.12.050
   Liberati Alessandro, 2009, PLoS Med, V6, pe1000100, DOI 10.1371/journal.pmed.1000100
   Liu YQ, 2015, CHIN J INTEGR MED, V21, P697, DOI 10.1007/s11655-014-2009-x
   Liu ZS, 2016, ANN INTERN MED, V165, P761, DOI 10.7326/M15-3118
   Mari A, 2020, KOREAN J FAM MED, V41, P139, DOI 10.4082/kjfm.18.0182
   Martin Bradley C, 2006, Manag Care Interface, V19, P43
   McCormick D, 2019, AM J MANAG CARE, V25, pS63
   McGraw T, 2016, CLIN EXP GASTROENTER, V9, DOI 10.2147/CEG.S111693
   McMillan Susan C, 2004, Cancer Control, V11, P3
   McMillan Susan C, 2013, Oncol Nurs Forum, V40, pE92, DOI 10.1188/13.ONF.E92-E100
   Mearin Fermin, 2016, Gastroenterology, DOI 10.1053/j.gastro.2016.02.031
   Michna E, 2011, J PAIN, V12, P554, DOI 10.1016/j.jpain.2010.11.008
   Mori T, 2013, J PHARMACOL EXP THER, V347, P91, DOI 10.1124/jpet.113.204313
   Nakajima A, 2019, J GASTROENTEROL, V54, P792, DOI 10.1007/s00535-019-01581-x
   National Comprehensive Cancer Network, 2020, NCCN CLIN PRACT ONC
   Nelson AD, 2017, GUT, V66, P1611, DOI 10.1136/gutjnl-2016-311835
   Paré P, 2014, CAN J GASTROENTEROL, V28, P549, DOI 10.1155/2014/631740
   Portenoy RK, 2008, J PAIN SYMPTOM MANAG, V35, P458, DOI 10.1016/j.jpainsymman.2007.12.005
   Rauck R, 2017, PAIN PRACT, V17, P820, DOI 10.1111/papr.12535
   Rauck RL, 2019, J PAIN RES, V12, P139, DOI 10.2147/JPR.S170086
   Reville B, 2009, PRIMARY CARE, V36, P781, DOI 10.1016/j.pop.2009.07.010
   Rhondali W, 2013, J PAIN SYMPTOM MANAG, V45, P23, DOI 10.1016/j.jpainsymman.2012.01.009
   Rithirangsriroj K, 2015, GYNECOL ONCOL, V136, P82, DOI 10.1016/j.ygyno.2014.10.025
   SHEA BJ, 2017, BMJ-BRIT MED J, V358, DOI DOI 10.1136/BMJ.14008
   Shen Q, 2018, WESTERN J NURS RES, V40, P874, DOI 10.1177/0193945917701128
   Shin J, 2018, WESTERN J NURS RES, V40, P67, DOI 10.1177/0193945916680362
   Slatkin Neal, 2009, J Support Oncol, V7, P39
   Sloots C.E.J., 2010, DIGEST DIS SCI, V55, P2912, DOI [10.1007/sio620-010-1229-y, DOI 10.1007/SIO62O-00-1229-Y]
   Speed C, 2010, HEALTH TECHNOL ASSES, V14, P1, DOI 10.3310/hta14520
   Spierings ELH, 2016, PAIN PRACT, V16, P985, DOI 10.1111/papr.12347
   Tarumi Y, 2013, J PAIN SYMPTOM MANAG, V45, P2, DOI 10.1016/j.jpainsymman.2012.02.008
   Thomas J, 2008, NEW ENGL J MED, V358, P2332, DOI 10.1056/NEJMoa0707377
   Tomich JL, 2019, CIN-COMPUT INFORM NU, V37, P551, DOI 10.1097/CIN.0000000000000598
   Webster L, 2014, ALIMENT PHARM THER, V40, P771, DOI 10.1111/apt.12899
   Webster L, 2018, PAIN PRACT, V18, P505, DOI 10.1111/papr.12640
   Webster L, 2013, PAIN, V154, P1542, DOI 10.1016/j.pain.2013.04.024
   Webster LR, 2018, J PAIN RES, V11, P2509, DOI 10.2147/JPR.S160625
   Webster LR, 2018, PAIN MED, V19, P1195, DOI 10.1093/pm/pnx212
   Webster LR, 2018, PAIN, V159, P987, DOI 10.1097/j.pain.0000000000001174
   Webster LR, 2017, PAIN MED, V18, P2350, DOI 10.1093/pm/pnw325
   WU J, 2014, MEDICINE, V93, DOI DOI 10.1097/MD0000000000000284
   Wu X, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/1428943
   Zheng H., 2018, NEUROGASTROENT MOTIL, V30, DOI [10.1111/nmo.13307, DOI 10.1111/NM0.13307]
NR 74
TC 9
Z9 11
U1 1
U2 31
PU ONCOLOGY NURSING SOC
PI PITTSBURGH
PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA
SN 0190-535X
EI 1538-0688
J9 ONCOL NURS FORUM
JI Oncol. Nurs. Forum
PD NOV
PY 2020
VL 47
IS 6
BP E211
EP E224
DI 10.1188/20.ONF.E211-E224
PG 14
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA OI2WH
UT WOS:000583144900003
PM 33063777
DA 2026-01-16
ER

PT J
AU Fu, YB
   Li, B
   Sun, SF
   Liu, HL
   Wang, X
   Wang, SS
   Zhang, F
   Du, X
   Ge, DJ
   Shang, L
   Liang, RL
   Wang, LN
   Yuan, F
   Sun, JQ
   Chen, JW
AF Fu, Yuan-Bo
   Li, Bin
   Sun, San-Feng
   Liu, Hui-Lin
   Wang, Xin
   Wang, Shao-Song
   Zhang, Fan
   Du, Xin
   Ge, Du-Juan
   Shang, Lei
   Liang, Rui-Li
   Wang, Li-Na
   Yuan, Fang
   Sun, Jing-Qing
   Chen, Jun-Wei
TI Fire acupuncture for mild to moderate knee osteoarthritis: a protocol
   for a randomized controlled pilot trial
SO TRIALS
LA English
DT Article
DE Knee Osteoarthritis; Fire Acupuncture; Basic health management
ID OUTCOMES; ARTHRITIS; THERAPY; PATIENT; HIP
AB Background: Knee osteoarthritis (KOA) is one of the most common bone and joint diseases. As one of the main non-drug therapies, acupuncture is widely used to treat KOA, although the evidence for its efficacy is inconclusive. The objective of this pilot trial is to clarify the clinical efficacy and safety of fire acupuncture in the treatment of mild to moderate KOA and to provide high-quality data for further research. Methods/design: This study is a prospective randomized controlled pilot trial in which 120 patients with mild to moderate KOA will be randomly allocated in equal proportions to a fire acupuncture group or a general acupuncture group. They will receive acupuncture for six sessions over 2 weeks. The primary end point is success rate, which will be calculated based on the change from baseline of the pain and function scores in the Western Ontario and McMaster Universities Osteoarthritis Index at 4 weeks. Secondary end points include the proportion of patients achieving clinical improvement based on: (1) the OMERACT-OARSI responder criteria, (2) levels of matrix metalloproteinase 3, interleukin 1 beta, and tumor necrosis factor a in blood, and (3) a subjective efficacy evaluation from patients.
C1 [Fu, Yuan-Bo; Li, Bin; Liu, Hui-Lin; Wang, Xin; Wang, Shao-Song; Zhang, Fan; Du, Xin; Yuan, Fang; Sun, Jing-Qing; Chen, Jun-Wei] Capital Med Univ, Dept Acupuncture & Moxibust, Beijing Hosp Tradit Chinese Med, Beijing Key Lab Acupuncture Neuromodulat, 23 Meishuguanhou St, Beijing 100010, Peoples R China.
   [Fu, Yuan-Bo; Sun, San-Feng; Ge, Du-Juan; Shang, Lei; Liang, Rui-Li; Wang, Li-Na] Beijing Huairou Dist Hosp Tradit Chinese Med, 1 Houheng St, Beijing 101400, Peoples R China.
   [Chen, Jun-Wei] Beijing Univ Chinese Med, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
C3 Capital Medical University; Beijing University of Chinese Medicine
RP Sun, JQ; Chen, JW (corresponding author), Capital Med Univ, Dept Acupuncture & Moxibust, Beijing Hosp Tradit Chinese Med, Beijing Key Lab Acupuncture Neuromodulat, 23 Meishuguanhou St, Beijing 100010, Peoples R China.; Chen, JW (corresponding author), Beijing Univ Chinese Med, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
EM sjgdoctor@163.com; 847431304@qq.com
RI fu, yuanbo/HGU-6186-2022
FU Beijing Huairou District Science and Technology Plan Project, Beijing
   Key Laboratory of Acupuncture Neuromodulation, Beijing, China [BZ0437,
   NY2019-6]; Beijing Municipal Hospital Research and Development Program
   [PZ2019019]
FX This work was supported by the Beijing Huairou District Science and
   Technology Plan Project, Beijing Key Laboratory of Acupuncture
   Neuromodulation, Beijing, China (BZ0437, award NY2019-6) and the Beijing
   Municipal Hospital Research and Development Program (award PZ2019019).
CR Aigner T, 2002, ARTHRITIS RHEUM-US, V46, P1986, DOI 10.1002/art.10554
   [Anonymous], 2014, OST CAR MAN AD
   [Anonymous], ACUPUNCTURE RES
   [Anonymous], 2010, BMJ-BRIT MED J, V340, DOI DOI 10.1136/BMJ.C332
   [Anonymous], INSP QUAR STAND MAN
   Baker K, 2000, CURR OPIN RHEUMATOL, V12, P456, DOI 10.1097/00002281-200009000-00020
   BELLAMY N, 1988, J RHEUMATOL, V15, P1833
   Brown GA, 2013, J AM ACAD ORTHOP SUR, V21, P577, DOI [10.5435/JAAOS-21-09-577, 10.5435/00124635-201309020-00009]
   Gobbi A, 2015, KNEE SURG SPORT TR A, V23, P2170, DOI 10.1007/s00167-014-2987-4
   Goldring MB, 2007, J CELL PHYSIOL, V213, P626, DOI 10.1002/jcp.21258
   GOLDSMITH CH, 1993, J RHEUMATOL, V20, P561
   Higgs Rowan, 2010, Nat Rev Rheumatol, V6, P616, DOI 10.1038/nrrheum.2010.165
   Hochberg MC, 2012, ARTHRIT CARE RES, V64, P465, DOI 10.1002/acr.21596
   Liu CZ, 2014, PAIN MED, V15, P910, DOI 10.1111/pme.12392
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Mavrommatis CI, 2012, PAIN, V153, P1720, DOI 10.1016/j.pain.2012.05.005
   O'Neill TW, 2018, BEST PRACT RES CL RH, V32, P312, DOI 10.1016/j.berh.2018.10.007
   Wang YD, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1392627
   Wu J N, 1996, J Altern Complement Med, V2, P19, DOI 10.1089/acm.1996.2.19
NR 19
TC 4
Z9 7
U1 1
U2 20
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD DEC 4
PY 2019
VL 20
IS 1
AR 673
DI 10.1186/s13063-019-3744-2
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KC0NC
UT WOS:000506883300004
PM 31801600
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Schuster, L
AF Schuster, Lynn
TI Integrative Medicine in the Oncology Setting, What Does the Research
   Show?
SO JNP-JOURNAL FOR NURSE PRACTITIONERS
LA English
DT Article
DE acupuncture; cancer; cancer prevention; complementary; complementary
   alternative medicine; integrative; integrative oncology; massage;
   meditation; supplements; yoga
ID BREAST-CANCER; INTERVENTIONS; MASSAGE; CHEMOTHERAPY; ACUPUNCTURE; PAIN
AB Most oncology patients are using some form of complementary alternative medicine (CAM). These can include acupuncture, massage, yoga, homeopathy, energy work, spiritual healers, vitamins and supplements, mind-body interventions, diets, and many other modalities. Although many of these interventions are safe and beneficial, some of them can be harmful. Unfortunately, because of time constraints, knowledge deficits, and the acuity of our patients, assessment of the use of CAM is often overlooked. As nurse practitioners, we must educate ourselves about the evidence for safety and efficacy of these interventions.
C1 [Schuster, Lynn] Univ Arizona, Integrat Med, Tucson, AZ 85721 USA.
C3 University of Arizona
RP Schuster, L (corresponding author), Univ Arizona, Integrat Med, Tucson, AZ 85721 USA.
EM Lynn.schuster2@bannerhealth.com
CR [Anonymous], 2014, Medicine Hands: Massage Therapy for People With Cancer
   [Anonymous], 2017, OMPLEMENTARY ALTERNA
   Bae K, 2015, INTEGR CANCER THER, V14, P496, DOI 10.1177/1534735415596573
   Boyd C, 2016, PAIN MED, V17, P1553, DOI 10.1093/pm/pnw100
   Cramer H, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010802.pub2
   Fouladbakhsh Judith M, 2013, J Adv Pract Oncol, V4, P289
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Haller H, 2017, ACTA ONCOL, V56, P1665, DOI 10.1080/0284186X.2017.1342862
   John GM, 2016, J CANCER SURVIV, V10, P850, DOI 10.1007/s11764-016-0530-y
   Lee RT, 2014, J CLIN ONCOL, V32, P4095, DOI 10.1200/JCO.2014.55.8676
   Millegan J, 2015, SUPPORT CARE CANCER, V23, P3393, DOI 10.1007/s00520-015-2891-6
   Mustian Karen M, 2013, Eur Med J Oncol, V1, P106
   Pan YQ, 2014, INT J CLIN ONCOL, V19, P829, DOI 10.1007/s10147-013-0635-5
   Robison JG, 2016, CLIN J ONCOL NURS, V20, pE34, DOI 10.1188/16.CJON.E34-E40
   Sharma M, 2016, J CANCER RES CLIN, V142, P2523, DOI 10.1007/s00432-016-2269-2
   Wu XY, 2015, SCI REP-UK, V5, DOI 10.1038/srep16776
   Yasueda A, 2016, INTEGR CANCER THER, V15, P17, DOI 10.1177/1534735415610427
   Zhang MF, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000897
NR 19
TC 1
Z9 1
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1555-4155
EI 1878-058X
J9 JNP-J NURSE PRACT
JI JNP-J. Nurse Pract.
PD APR
PY 2018
VL 14
IS 4
BP 276
EP 282
DI 10.1016/j.nurpra.2017.11.015
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA GC8QS
UT WOS:000430061700018
DA 2026-01-16
ER

PT J
AU Shi, HY
   Chen, H
   Gao, S
   Fang, JF
   Zhu, LL
   Liu, ZS
AF Shi, Hangyu
   Chen, Huan
   Gao, Shuai
   Fang, Jiufei
   Zhu, Lili
   Liu, Zhishun
TI Acupuncture for cyclic and noncyclic breast pain in women: A systematic
   review and meta-analysis of randomized controlled trials
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Review
DE Acupuncture; Breast pain; Mastodynia; Systematic review; Meta-analysis
ID CLINICAL MANAGEMENT; MASTALGIA; SEVERITY; SYMPTOMS
AB Introduction: Breast pain is a frequently encountered problem in both pre- and postmenopausal women. The pain can be severe and persistent, and interferes with women's daily life. Acupuncture has been widely used for women with cyclic and noncyclic breast pain with possible favorable effects and few adverse events, however, the data have not been systematically reviewed. This systematic review aims to investigate the efficacy of acupuncture on alleviating breast pain. Methods: Seven databases including Medline, Embase, Pubmed, CNKI, etc. were searched for English and Chinese literature from their inception to 22 January 2024. We included randomized clinical trials that assessed the effectiveness of acupuncture in reducing pain intensity for cyclic and noncyclic mastalgia unrelated to cancer. Two independent reviewers screened the retrieved studies and extracted the data. Risk of bias of included studies was assessed according to Cochrane Risk-of-Bias (RoB) tool version 2. Meta-analysis was conducted where applicable. Results: Eleven studies were included. Eight studies with 588 women focused on cyclic breast pain (CBP), three studies with 210 women focused on noncyclic breast pain (NCBP). For CBP, the overall response rate of acupuncture was comparable to tamoxifen (3 studies, n=243; RR 1.24, 95% CI 0.75 to 2.06, p=0.39; very low certainty), however, the effect of acupuncture measured by visual analogue scale (VAS) score was inconsistent when compared with sham acupuncture in 3 studies (n=141; MD 11.08, 95% CI -3.95 to 26.10; p = 0.15; very low certainty). For NCBP, acupuncture provided significantly more reduction in VAS score than antibiotics for mastitis (2 studies, n=148; MD 12.69, 95% CI 8.38 to 17.00; p < 0.001; low certainty). A total of five cases of adverse events were reported. Conclusion: Acupuncture may have similar effects to tamoxifen in treating women with CBP, and may be more effective than antibiotics in alleviating breast pain for women with mastitis. Acupuncture may be an effective complementary treatment for breast pain. However, the overall certainty of evidence was very low. The evidence was not conclusive and requires further investigation with robust methodological quality.
C1 [Shi, Hangyu] Beijing Univ Chinese Med, Beijing, Peoples R China.
   [Shi, Hangyu; Gao, Shuai; Fang, Jiufei; Zhu, Lili; Liu, Zhishun] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Acupuncture, 5 Beixiange Xicheng Dist, Beijing 100053, Peoples R China.
   [Chen, Huan] Inst Acupuncture & Moxibust, China Acad Chinese Med Sci, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; China Academy of Chinese Medical
   Sciences; Guang'anmen Hospital, CACMS; Institute of Acupuncture &
   Moxibustion, CACMS; China Academy of Chinese Medical Sciences
RP Liu, ZS (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Acupuncture, 5 Beixiange Xicheng Dist, Beijing 100053, Peoples R China.
EM zhishunjournal@163.com
OI Shi, Hangyu/0009-0009-9664-8453; Liu, Zhishun/0000-0001-7570-8917
FU Fundamental Research Funds for the Central Public Welfare Research
   Institutes [ZZ13-024-9]
FX The Fundamental Research Funds for the Central Public Welfare Research
   Institutes (ZZ13-024-9)
CR [Anonymous], 2004, BMJ
   Armour M, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005290.pub2
   Befus D, 2018, J ALTERN COMPLEM MED, V24, P314, DOI 10.1089/acm.2016.0408
   [陈冬 Chen Dong], 2016, [南京中医药大学学报, Journal of Nanjing University of Traditional Chinese Medicine], V32, P134
   Cheng K, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011075.pub2
   Cook N, 2020, EUR J BREAST HEALTH, V16, P267, DOI 10.5152/ejbh.2020.5730
   Cornell LF, 2020, MAYO CLIN PROC, V95, P574, DOI 10.1016/j.mayocp.2019.12.014
   Duijm LEM, 1998, BRIT MED J, V317, P1492, DOI 10.1136/bmj.317.7171.1492
   Farrar JT, 2001, PAIN, V94, P149, DOI 10.1016/S0304-3959(01)00349-9
   Feng R, 2015, DIAGN PATHOL, V10, DOI 10.1186/s13000-015-0382-1
   Gallagher EJ, 2001, ANN EMERG MED, V38, P633, DOI 10.1067/mem.2001.118863
   Goyal A., 2011, BMJ Clin. Evid., V2011
   Groen JW, 2017, EUR J OBSTET GYN R B, V219, P74, DOI 10.1016/j.ejogrb.2017.10.018
   Hafiz SP, 2018, J PRIM HEALTH CARE, V10, P312, DOI 10.1071/HC18026
   Hawker GA, ARTHRITIS CARE RES
   Hubbard TJE, 2020, BRIT J GEN PRACT, V70, P419, DOI 10.3399/bjgp20X712133
   Kvist L J, 2004, Int Nurs Rev, V51, P56, DOI 10.1111/j.1466-7657.2003.00205.x
   Kvist LJ, 2007, MIDWIFERY, V23, P184, DOI 10.1016/j.midw.2006.02.003
   Lai HC, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6173412
   Lavoue Vincent, Clinical practice guidelines from the French College of Gynecologists and Obstetricians (CNGOF): benign breast tumors-short text
   Lee JS, 2003, ACAD EMERG MED, V10, P1128, DOI 10.1197/S1069-6563(03)00372-5
   Liang C, 2011, J. Pract. Tradit. Chin. Internal Med, V25, P91
   Liu SB, 2021, NATURE, V598, P641, DOI 10.1038/s41586-021-04001-4
   Liu X, 2021, Chin. Med. Mod. Distance Educ. China., V19, P122
   MacPherson H, 2016, ANN INTERN MED, V164, P376, DOI 10.7326/L15-0632
   Main CJ, 2016, PAIN, V157, P1387, DOI 10.1097/j.pain.0000000000000457
   Mallory MJ, 2015, AM J CHINESE MED, V43, P45, DOI 10.1142/S0192415X15500032
   Martín-Díaz M, 2017, CURR OPIN OBSTET GYN, V29, P404, DOI 10.1097/GCO.0000000000000407
   McHann MC, 2021, MOL CELL ENDOCRINOL, V533, DOI 10.1016/j.mce.2021.111320
   Millet AV, 2002, OBSTET GYNECOL SURV, V57, P451, DOI 10.1097/00006254-200207000-00022
   Mirghafourvand M, 2016, COMPLEMENT THER MED, V24, P90, DOI 10.1016/j.ctim.2015.12.009
   Noroozian M, 2015, BREAST CANCER RES TR, V149, P417, DOI 10.1007/s10549-014-3257-3
   Oh JE, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.813748
   Ooi SL, 2020, J WOMENS HEALTH, V29, P262, DOI 10.1089/jwh.2019.7770
   Osterman K L, 2000, J Hum Lact, V16, P297, DOI 10.1177/089033440001600405
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n160, 10.1136/bmj.n71, 10.1038/nchembio.2180, 10.1186/s40900-023-00424-7, 10.3390/jpm13020373]
   Qian C., 2021, Shanghai J. Acu-mox, V40
   Rosolowich V, 2006, J OBSTET GYNAECOL CA, V28, P49, DOI 10.1016/S1701-2163(16)32027-8
   Scurr J, 2014, BREAST J, V20, P508, DOI 10.1111/tbj.12305
   Sinha MK, 2022, J OBSTET GYNAECOL CA, V44, P1084, DOI 10.1016/j.jogc.2022.06.006
   Smith RL, 2004, MAYO CLIN PROC, V79, P353, DOI 10.4065/79.3.353
   Srivastava A, 2007, BREAST, V16, P503, DOI 10.1016/j.breast.2007.03.003
   Su Y, 2020, Our Health
   Sun M., 2018, The Effectiveness of Acupuncture in Relieving Periodic Mastodynia, a Randomised Controlled Trial
   Sun YJ, 2021, ANN INTERN MED, V174, P1357, DOI 10.7326/M21-1814
   World Health Organization, 2003, Mastitis Causes and management
   Xie J, 2006, The CIinical and ExperimentaI Research of SexuaI Hormone in Treating HyperpIasia of Mammary Glands by EIectric-Acupuncture
   Yang JM, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-056878
   Yu C., 2021, Chin. Med. Mod. Distance Educ. China, V19, P109
   Zhang JY, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6246285
   Zhang X, 2021, China's Naturopathy., V29
   Zhang X., 2020, The Efficacy and Safety of Acupuncture in Relieving Moderate to Severe Cyclical Breast Pain
   Zhang YZ, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.646315
   Zhao FY, 2023, FRONT PUBLIC HEALTH, V11, DOI 10.3389/fpubh.2023.1120567
   Zhao L, 2017, JAMA INTERN MED, V177, P508, DOI 10.1001/jamainternmed.2016.9378
   Zhou J, 2020, Chin. J. New Clin. Med, V13, P811
   Zhu FY, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.786401
NR 57
TC 0
Z9 0
U1 4
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD JUN
PY 2024
VL 68
AR 102355
DI 10.1016/j.eujim.2024.102355
EA APR 2024
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA PY3Z6
UT WOS:001217613900001
OA hybrid
DA 2026-01-16
ER

PT J
AU Liou, KT
   Mao, JJ
AF Liou, Kevin T.
   Mao, Jun J.
TI In reply to "could acupuncture be a treatment option for cancer patients
   with attitudinal barriers to pharmacological pain management?" by Kako,
   Kajiwara, and Kobayashi
SO SUPPORTIVE CARE IN CANCER
LA English
DT Letter
C1 [Liou, Kevin T.; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
C3 Memorial Sloan Kettering Cancer Center
RP Liou, KT (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
EM liouk@mskcc.org
OI Liou, Kevin/0000-0002-2438-9749
FU National Cancer Institute [P30CA008748] Funding Source: NIH RePORTER;
   NCI NIH HHS [3P30CA008748-50, 3P30CA008748-50] Funding Source: Medline
CR Bauml JM, 2015, CANCER-AM CANCER SOC, V121, P2431, DOI 10.1002/cncr.29173
   Liou KT, 2021, SUPPORT CARE CANCER, V29, P427, DOI 10.1007/s00520-020-05504-y
   Mao JJ, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/798098
   Swarm RA, 2019, J NATL COMPR CANC NE, V17, P977, DOI 10.6004/jnccn.2019.0038
NR 4
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JAN
PY 2021
VL 29
IS 1
BP 5
EP 5
DI 10.1007/s00520-020-05844-9
EA OCT 2020
PG 1
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA RI9WR
UT WOS:000585671300001
PM 33111181
OA Bronze
DA 2026-01-16
ER

PT J
AU Zhang, RY
   Zhu, BF
   Zhao, JG
   Zhao, L
   Wang, LK
AF Zhang, Rong Yi
   Zhu, Ben Fan
   Zhao, Jia Gui
   Zhao, Long
   Wang, Li Kui
TI Electroacupuncture Stimulation Alleviates Inflammatory Pain in Male Rats
   by Suppressing Oxidative Stress
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Electroacupuncture; Inflammatory pain; Oxidative stress; Reactive oxygen
   species; TRPV1
ID MECHANISMS; INJURY; MODEL
AB In the present study, we focused on whether the analgesic effect of Electroacupuncture (EA) is related to the regulation of oxidative stress. We established a chronic inflammatory pain model in male rats by a single injection of complete Freund's adjuvant (CFA) and then treated the animals with daily EA stimulation at the site of "zusanli". The analgesic effect of EA was evaluated by measuring the paw withdrawal threshold (PWT) when rats received mechanical and thermal pain stimulation. The levels of inflammation-related molecules and oxidative stress-related markers in the spinal cord were measured by western blotting or ELISA kits. EA stimulation and antioxidants effectively increased the PWT in CFA rats. Co-treatment of CFA rats with the ROS donor t-butyl hydroperoxide (t-BOOH) further decreased the PWT and weakened the analgesic effect of EA. EA treatment inhibited inflammation and oxidative stress, as shown by decreased levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), IL-6, and MDA and increased activity of SOD and catalase. Moreover, EA reduced the expression of p-p38, p-ERK, and p-p65 and simultaneously downregulated the expression of TRPV1 and TRPV4 in CFA rats. In an in vitro study, direct stimulation with t-BOOH to the C6 cells increased the production of TNF-alpha, IL-10, IL-6, activated p38, ERK, and p65 and up-regulated the expression of TRPV1 and TRPV4, and these effects could be prevented by the ROS scavenger PBN. Taken together, our data indicate that the inhibition of oxidative stress and the generation of ROS contribute to the analgesic effect of EA in male CFA rats.
C1 [Zhang, Rong Yi; Zhu, Ben Fan; Zhao, Jia Gui; Zhao, Long; Wang, Li Kui] Anhui Med Univ, Affiliated Hosp 1, Dept Pain Management, Hefei, Anhui, Peoples R China.
   [Wang, Li Kui] Anhui Med Univ, Hosp Hefei, Dept Pain Management, Hefei, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Wang, LK (corresponding author), Anhui Med Univ, Hosp Hefei, Dept Pain Management, Hefei, Peoples R China.
EM wlk9560@163.com
FU National Natural Science Foundation of Anhui Province [1808085MH310];
   First Affiliated Hospital of Anhui Medical University [3101005001249]
FX This work was supported by the National Natural Science Foundation of
   Anhui Province (No. 1808085MH310) and by Grants for Scientific Research
   of BSKY (No. 3101005001249) from the First Affiliated Hospital of Anhui
   Medical University.
CR Abbas MA, 2020, CHEM-BIOL INTERACT, V330, DOI 10.1016/j.cbi.2020.109178
   Chen G, 2018, NEURON, V100, P1292, DOI 10.1016/j.neuron.2018.11.009
   Descalzi G, 2015, TRENDS NEUROSCI, V38, P237, DOI 10.1016/j.tins.2015.02.001
   Ebert T J, 1996, Acta Anaesthesiol Belg, V47, P15
   Fan JJ, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-2317-3
   Gao F, 2018, BRAIN BEHAV IMMUN, V67, P91, DOI 10.1016/j.bbi.2017.08.004
   Hanamoto H, 2015, BMC ANESTHESIOL, V15, DOI 10.1186/s12871-015-0047-3
   Hassler SN, 2014, J NEUROCHEM, V131, P413, DOI 10.1111/jnc.12830
   Hudmon A, 2008, J NEUROSCI, V28, P3190, DOI 10.1523/JNEUROSCI.4403-07.2008
   Kim HY, 2015, NEURAL PLAST, V2015, DOI 10.1155/2015/293423
   Kim HK, 2004, PAIN, V111, P116, DOI 10.1016/j.pain.2004.06.008
   Kozai D, 2014, ANTIOXID REDOX SIGN, V21, P971, DOI 10.1089/ars.2013.5616
   Lawrence T, 2009, CSH PERSPECT BIOL, V1, DOI 10.1101/cshperspect.a001651
   Li YY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235917
   Liang RY, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/3056963
   Lin X, 2014, CURR MED CHEM, V21, P4405, DOI 10.2174/0929867321666140915143040
   Liu PR, 2019, J INT MED RES, V47, P3860, DOI 10.1177/0300060519860026
   Liu YJ, 2021, PHYSIOL RES, V70, P635, DOI 10.33549/physiolres.934649
   Lu QB, 2018, REDOX BIOL, V14, P656, DOI 10.1016/j.redox.2017.11.012
   Lv ZT, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1899-6
   Ma F, 2009, MOL PAIN, V5, DOI 10.1186/1744-8069-5-31
   Maruta T, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0225586
   Moran MM, 2018, BRIT J PHARMACOL, V175, P2185, DOI 10.1111/bph.14044
   Oda M, 2021, BIOCHEM BIOPHYS REP, V28, DOI 10.1016/j.bbrep.2021.101173
   Pinho-Ribeiro FA, 2017, TRENDS IMMUNOL, V38, P5, DOI 10.1016/j.it.2016.10.001
   Ratliff BB, 2016, ANTIOXID REDOX SIGN, V25, P119, DOI 10.1089/ars.2016.6665
   Schäfers M, 2003, PAIN, V104, P579, DOI 10.1016/S0304-3959(03)00115-5
   Sekiguchi M, 2009, EUR SPINE J, V18, P1978, DOI 10.1007/s00586-009-1064-z
   Shakouri SK, 2020, BMC RES NOTES, V13, DOI 10.1186/s13104-020-05352-3
   Sommer C, 1999, NEUROSCI LETT, V270, P25, DOI 10.1016/S0304-3940(99)00450-4
   Sorge RE, 2017, J NEUROSCI RES, V95, P1271, DOI 10.1002/jnr.23841
   Uta D, 2019, NEUROPHARMACOLOGY, V160, DOI 10.1016/j.neuropharm.2019.107753
   Webster Lynn R, 2016, Anesthesiol Clin, V34, P341, DOI [10.1016/j.anclin.2016.01.002, 10.1016/j.anclin.2016.01.002]
   Xiang XN, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20133248
   Xue Y, 2020, MOL PAIN, V16, DOI 10.1177/1744806920929246
   Zhang RY, 2020, ARQ NEURO-PSIQUIAT, V78, P617, DOI [10.1590/0004-282X20200078, 10.1590/0004-282x20200078]
   Zhao XM, 2019, PHYSIOL RES, V68, P501, DOI 10.33549/physiolres.934084
   Zheng YJ, 2020, LIBYAN J MED, V15, DOI 10.1080/19932820.2020.1730550
NR 38
TC 8
Z9 8
U1 1
U2 8
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD OCT
PY 2023
VL 72
IS 5
BP 657
EP 667
DI 10.33549/physiolres.934965
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CQ1R9
UT WOS:001126623900008
PM 38015764
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Spraker-Perlman, HL
   Busby, KM
   Ly, A
   Meyer, M
   Baker, JN
   Levine, DR
AF Spraker-Perlman, Holly L.
   Busby, Kenneth M.
   Ly, Amy
   Meyer, Maggi
   Baker, Justin N.
   Levine, Deena R.
TI Pediatric Hematology-Oncology Provider Attitudes and Beliefs About the
   Use of Acupuncture for Their Patients
SO CHILDREN-BASEL
LA English
DT Article
DE pediatrics; children; oncology; cancer; acupuncture; survey; needs
   assessment; integrative medicine
ID INTEGRATIVE MEDICINE; PAIN MANAGEMENT; SAFETY; CHILDREN
AB Background/Objectives: Children with cancer suffer due to the underlying disease and prescribed cancer-directed therapies, and non-pharmacologic modalities may offer improved symptom control without additional medications. We sought to elicit knowledge, attitudes, and beliefs of Pediatric Hematology Oncology (PHO) providers surrounding the incorporation of acupuncture for symptom management for their patients. Methods: A cross-sectional survey instrument was created, formatted, and delivered to physicians and advanced practice providers (APPs) at a single US pediatric cancer center. Survey responses were summarized by descriptive statistics. Results: A total of 78 PHO clinicians participated (response rate 29%). Most participants were interested in learning more about acupuncture (n = 42, 56.0%), yet rarely (n = 17, 22.7%) or never (n = 46, 61.3%) recommend acupuncture to patients. Most (n = 51, 73.9%) noted that they would support institutional development of an acupuncture program. Over half (n = 37, 52.2%) indicated their threshold for minimum hematologic indices for acupuncture includes a platelet count greater than 20,000 and absolute neutrophil count (ANC) greater than 500 (n = 37, 54.4%). Approximately two-thirds (n = 52, 66.7%) of participants noted that acupuncture could improve their patient's quality of life, and most (n = 46, 67.6%) were not worried about harm. Conclusions: Acupuncture for symptom management is an evidenced-based, guideline-concordant recommendation for adults with cancer, but robust data in the pediatric oncology population are lacking. PHO providers do not routinely recommend acupuncture for patients but note that it may improve quality of life. Given their high symptom burden, rigorous studies of non-pharmacologic strategies for pediatric symptom management are vital. Acupuncture should be examined as a potential beneficial adjunct.
C1 [Spraker-Perlman, Holly L.] Univ Utah, Primary Childrens Hosp, Dept Pediat, Div Pediat Hematol Oncol & Pediat Palliat Care, Salt Lake City, UT 84113 USA.
   [Busby, Kenneth M.] Stanford Univ, Dept Pediat, Palo Alto, CA 94304 USA.
   [Ly, Amy] St Jude Childrens Res Hosp, Dept Pediat Med, Div Pediat Neurol, Memphis, TN 38105 USA.
   [Meyer, Maggi] St Jude Childrens Res Hosp, Dept Rehabil Med, Memphis, TN 38105 USA.
   [Baker, Justin N.] Stanford Univ, Dept Pediat, Div Qual Life & Pediat Palliat Care, Sch Med, Palo Alto, CA 94305 USA.
   [Levine, Deena R.] St Jude Childrens Res Hosp, Dept Oncol, Div Qual Life & Palliat Care, Memphis, TN 38105 USA.
C3 Utah System of Higher Education; University of Utah; Stanford
   University; St Jude Children's Research Hospital; St Jude Children's
   Research Hospital; Stanford University; St Jude Children's Research
   Hospital
RP Spraker-Perlman, HL (corresponding author), Univ Utah, Primary Childrens Hosp, Dept Pediat, Div Pediat Hematol Oncol & Pediat Palliat Care, Salt Lake City, UT 84113 USA.
EM holly.spraker-perlman@hsc.utah.edu; kmbusby@stanford.edu;
   amy.ly@stjude.org; maggi.meyer@stjude.org; jusbaker@stanford.edu;
   deena.levine@stjude.org
RI Baker, Justin/N-8117-2018; Spraker-Perlman, Holly/N-8099-2018
OI Baker, Justin/0000-0002-6584-6483; Levine, Deena/0000-0002-3206-5648;
   Busby, Kenneth/0000-0003-1199-0081
FU American Lebanese Syrian Associated charities (ALSAC)
FX This work was sponsored for faculty at St. Jude Children's Research
   Hospital (SJCRH) by the American Lebanese Syrian Associated charities
   (ALSAC), the fund-raising arm of SJCRH.
CR Ast A, 2021, OBM Integrative and Complementary Medicine, V6, DOI [10.21926/obm.icm.2101005, 10.21926/obm.icm.2101005, DOI 10.21926/OBM.ICM.2101005]
   Bao T, 2021, ONCOLOGIST, V26, pE2070, DOI 10.1002/onco.13933
   Barnhart BJ, 2021, EVAL HEALTH PROF, V44, P245, DOI 10.1177/01632787211019445
   Beer TM, 2010, UROLOGY, V76, P1182, DOI 10.1016/j.urology.2010.03.033
   Bodner K, 2018, COMPLEMENT THER MED, V38, P79, DOI 10.1016/j.ctim.2018.05.001
   Chokshi SK, 2017, PEDIATR BLOOD CANCER, V64, DOI 10.1002/pbc.26424
   de Valois B, 2024, SUPPORT CARE CANCER, V32, DOI 10.1007/s00520-024-08386-6
   Ezzo J, 2005, J CLIN ONCOL, V23, P7188, DOI 10.1200/JCO.2005.06.028
   Filshie Jacqueline, 2006, Acupunct Med, V24, P172
   García EM, 2024, CANCERS, V16, DOI 10.3390/cancers16183197
   Highfield ES, 2006, J ALTERN COMPLEM MED, V12, P317, DOI 10.1089/acm.2006.12.317
   Johnson A, 2015, ALTERN COMPLEMENT TH, V21, P255, DOI [10.1089/act.2015.29022.ajo, 10.1089/act.2015.29022.ajo, DOI 10.1089/act.2015.29022.ajo]
   Kayo T, 2024, J INTEGR COMPLEMENT, V30, P77, DOI 10.1089/jicm.2022.0710
   Kemper K., 2004, Contemporary Pediatrics, V21, P61
   Kemper KJ, 2000, PEDIATRICS, V105, P941
   Ladas EJ, 2010, SUPPORT CARE CANCER, V18, P1487, DOI 10.1007/s00520-010-0926-6
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Lin YC, 2020, J TRADIT COMPL MED, V10, P315, DOI 10.1016/j.jtcme.2019.08.004
   Lu WD, 2024, CANCER-AM CANCER SOC, V130, P3219, DOI 10.1002/cncr.35374
   Lu WD, 2010, CURR TREAT OPTION ON, V11, P141, DOI 10.1007/s11864-010-0126-0
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Martin CS, 2019, ACTA ANAESTH SCAND, V63, P292, DOI 10.1111/aas.13288
   Metcalf RA, 2025, JAMA-J AM MED ASSOC, V334, P606, DOI 10.1001/jama.2025.7529
   Mora DC, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03537-w
   Morey SS, 1998, AM FAM PHYSICIAN, V57, P2545
   Murphy CC, 2020, BMC MED RES METHODOL, V20, DOI 10.1186/s12874-020-01014-x
   National Comprehensive Cancer Center National Comprehensive Cancer Network, 2025, Clinical Practice Guidelines in Oncology-Survivorship-Physician Guidelines
   PDQ Integrative Alternative and Complementary Therapies Editorial Board, 2002, Acupuncture (PDQ®): Health Professional Version. PDQ Cancer Information Summaries
   Roth M, 2009, J PEDIAT HEMATOL ONC, V31, P177, DOI 10.1097/MPH.0b013e3181984f5a
   Schneider Craig D, 2003, BMC Med Educ, V3, P5, DOI 10.1186/1472-6920-3-5
   Spraker-Perlman HL, 2025, J NATL COMPR CANC NE, V23, DOI 10.6004/jnccn.2025.7021
   Witt CM, 2009, FORSCH KOMPLEMENTMED, V16, P91, DOI 10.1159/000209315
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 33
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD JUL 22
PY 2025
VL 12
IS 8
AR 961
DI 10.3390/children12080961
PG 11
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 6NC2T
UT WOS:001557294200001
PM 40868413
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yang, GS
   Kim, HJ
   Griffith, KA
   Zhu, SJ
   Dorsey, SG
   Renn, CL
AF Yang, Gee Su
   Kim, Hee Jun
   Griffith, Kathleen A.
   Zhu, Shijun
   Dorsey, Susan G.
   Renn, Cynthia L.
TI Interventions for the Treatment of Aromatase Inhibitor-Associated
   Arthralgia in Breast Cancer Survivors
SO CANCER NURSING
LA English
DT Article
DE Aromatase inhibitor; Arthralgia; Breast cancer; Intervention;
   Meta-analysis; Systematic review
ID ADJUVANT ENDOCRINE THERAPY; PRACTICE GUIDELINE UPDATE; MUSCULOSKELETAL
   SYMPTOMS; JOINT SYMPTOMS; DOUBLE-BLIND; POSTMENOPAUSAL WOMEN; AMERICAN
   SOCIETY; CONTROLLED TRIAL; PHASE-II; ACUPUNCTURE
AB Background: Aromatase inhibitors (AIs) have been established as successful adjuvant therapy for breast cancer survivors. Unfortunately, nearly half of women taking AIs report joint pain, AI-associated arthralgia (AIA). Aromatase inhibitor-associated arthralgia often results in noncompliance, which could lead to cancer recurrence. Objective: The purpose of this study was to identify current pain management of AIA and to evaluate the study quality and effects of interventions. Methods: Nineteen articles published from 2000 to August 2015 were identified using PubMed, CINAHL, PsycINFO, Web of Science, and additional records. Study quality was evaluated by the Quality Assessment Tool for Quantitative Studies. Meta-analysis was used to obtain effect sizes of interventions on pain and subgroups. Results: Five types of interventions emerged: pharmacological approaches, acupuncture, nutritional supplementation, relaxation techniques, and physical exercise. Six studies were strong, 8 were moderate, and 5 were weak in quality. The overall effect size of the interventions on pain was large; pharmacological approaches, acupuncture, and relaxation techniques showed moderate to large effects on pain, whereas nutritional supplementation and physical exercise had no significant effects on it. Conclusion: The evidence was based on a body of research with moderate study quality. Although the overall effect of interventions is large, further investigation into the influence of nutrition and physical exercise is needed to better discern their potential for pain management. Implication for Practice: Oncology nurses may be able to implement such validated interventions as pain management modalities to mitigate the symptoms so that breast cancer survivors remain compliant with AIA therapy.
C1 [Yang, Gee Su; Kim, Hee Jun; Griffith, Kathleen A.; Dorsey, Susan G.; Renn, Cynthia L.] Univ Maryland, Sch Nursing, Dept Pain & Translat Symptom Sci, 655 W Lombard St, Baltimore, MD 21201 USA.
   [Zhu, Shijun] Univ Maryland, Sch Nursing, Dept Org Syst & Adult Hlth, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore
RP Renn, CL (corresponding author), Univ Maryland, Sch Nursing, Dept Pain & Translat Symptom Sci, 655 W Lombard St, Baltimore, MD 21201 USA.
EM renn@son.umaryland.edu
RI Kim, Hee Jun/LVC-1869-2024
OI Griffith, Kathleen/0000-0003-2091-2018
FU Oncology Nursing Society Foundation/Purdue Pharmaceuticals Trish Greene
   Pain Assessment and Management research grant
FX This work is supported by an Oncology Nursing Society Foundation/Purdue
   Pharmaceuticals Trish Greene Pain Assessment and Management research
   grant.
CR American Cancer Society, CANC FACTS FIG 2015
   Arrow KJ, 1996, SCIENCE, V272, P221, DOI 10.1126/science.272.5259.221
   Atkins D, 2004, BMJ-BRIT MED J, V328, P1490
   Bae K, 2015, INTEGR CANCER THER, V14, P496, DOI 10.1177/1534735415596573
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Borenstein M, 2009, INTRO METAANALYSIS
   Briot K, 2010, BREAST CANCER RES TR, V120, P127, DOI 10.1007/s10549-009-0692-7
   Burstein HJ, 2007, J CLIN ONCOL, V25, DOI 10.1200/JCO.2007.11.9529
   Burstein HJ, 2010, J CLIN ONCOL, V28, P3784, DOI 10.1200/JOP.000082
   Carlson KD, 1999, J APPL PSYCHOL, V84, P851, DOI 10.1037/0021-9010.84.6.851
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Crew Katherine D, 2007, J Cancer Surviv, V1, P283, DOI 10.1007/s11764-007-0034-x
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Cuzick J, 2010, LANCET ONCOL, V11, P1135, DOI 10.1016/S1470-2045(10)70257-6
   DeNysschen CA, 2014, EUR J CANCER CARE, V23, P493, DOI 10.1111/ecc.12155
   Fields J., 2015, THESIS
   Fontein DBY, 2012, EJSO-EUR J SURG ONC, V38, P110, DOI 10.1016/j.ejso.2011.11.010
   Gaillard S, 2011, BREAST CANCER RES, V13, DOI 10.1186/bcr2818
   Galantino ML, 2013, ALTERN THER HEALTH M, V19, P38
   Galantino ML, 2012, INTEGR CANCER THER, V11, P313, DOI 10.1177/1534735411413270
   Greenlee H, 2013, SUPPORT CARE CANCER, V21, P1077, DOI 10.1007/s00520-012-1628-z
   Henry NL, 2008, BREAST CANCER RES TR, V111, P365, DOI 10.1007/s10549-007-9774-6
   Henry NL, 2015, J CLIN ONCOL, V33, P1870, DOI 10.1200/JCO.2015.61.1004
   Henry NL, 2011, CANCER-AM CANCER SOC, V117, P5469, DOI 10.1002/cncr.26230
   Hershman DL, 2015, J CLIN ONCOL, V33, P1910, DOI 10.1200/JCO.2014.59.5595
   Irwin ML, 2015, J CLIN ONCOL, V33, P1104, DOI 10.1200/JCO.2014.57.1547
   Kubo M, 2012, ANTICANCER RES, V32, P2331
   Laroche F, 2014, J PAIN, V15, P293, DOI 10.1016/j.jpain.2013.11.004
   Liberati A., 2009, PLoS Med, V62, pe1, DOI [DOI 10.1371/journal.pmed.1000100, 10.1136/bmj.b2700, DOI 10.7326/0003-4819-151-4-200908180-00136, 10.1016/j.jclinepi.2009.06.006, DOI 10.1016/J.JCLINEPI.2009.06.006]
   Lintermans A, 2011, STEROIDS, V76, P781, DOI 10.1016/j.steroids.2011.02.034
   Mao JJ, 2009, INTEGR CANCER THER, V8, P123, DOI 10.1177/1534735409332903
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Menas Pamela, 2012, J Oncol Pharm Pract, V18, P387, DOI 10.1177/1078155211434853
   Nabholtz Jean-Marc A, 2008, Ther Clin Risk Manag, V4, P189
   Nevitt MC, 2001, ARTHRITIS RHEUM-US, V44, P811, DOI 10.1002/1529-0131(200104)44:4<811::AID-ANR137>3.0.CO;2-F
   Nyrop KA, 2014, J GERIATR ONCOL, V5, P148, DOI 10.1016/j.jgo.2013.12.002
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Rastelli AL, 2011, BREAST CANCER RES TR, V129, P107, DOI 10.1007/s10549-011-1644-6
   Rothstein HR, 2005, PUBLICATION BIAS IN META-ANALYSIS: PREVENTION, ASSESSMENT AND ADJUSTMENTS, P1, DOI 10.1002/0470870168
   Thomas B H, 2004, Worldviews Evid Based Nurs, V1, P176, DOI 10.1111/j.1524-475X.2004.04006.x
   Turner RM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059202
   Zhang QY, 2010, AM J CLIN ONCOL-CANC, V33, P557, DOI 10.1097/COC.0b013e3181cae782
NR 42
TC 36
Z9 43
U1 0
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD JUL-AUG
PY 2017
VL 40
IS 4
BP E26
EP E41
DI 10.1097/NCC.0000000000000409
PG 16
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA EY2PP
UT WOS:000403811400003
PM 27333128
DA 2026-01-16
ER

PT J
AU Bae, K
   Lamoury, G
   Carroll, S
   Morgia, M
   Lim, S
   Baron-Hay, S
   Shin, IS
   Park, SJ
   Oh, B
AF Bae, Kyeore
   Lamoury, Gillian
   Carroll, Susan
   Morgia, Marita
   Lim, Stephanie
   Baron-Hay, Sally
   Shin, In-Soo
   Park, So-Jung
   Oh, Byeongsang
TI Comparison of the clinical effectiveness of treatments for aromatase
   inhibitor-induced arthralgia in breast cancer patients: A systematic
   review with network meta-analysis
SO CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
LA English
DT Review
DE Breast cancer; Aromatase inhibitor; Pain; Quality of life; Network
   meta-analysis
ID MUSCULOSKELETAL SYMPTOMS; POSTMENOPAUSAL WOMEN; COMPARATIVE EFFICACY;
   CONTROLLED TRIAL; DOUBLE-BLIND; VITAMIN-D; PHASE-II; ACUPUNCTURE; PAIN;
   THERAPY
AB Aromatase inhibitor-induced arthralgia (AIA) contributes to poor adherence of aromatase inhibitor therapies in patients with breast cancer. A systematic review using network meta-analysis (NMA) was conducted to examine the clinical effectiveness of multiple therapies and rank probabilities for the management of AIA. Randomized controlled trials (RCTs) assessing treatments for AIA in postmenopausal women with stage 0-III hormone receptor-positive breast cancer were searched from inception to October 2021. The main NMA involved 1516 participants from 17 RCTs. Acupuncture was the highest ranked intervention to improve pain intensity followed by sham acupuncture, multicomponent herbal medicine, exercise, duloxetine, vitamin D, omega-3 fatty acids, physical therapy, testosterone, and inactive controls. Single natural products were inferior to controls. The current review provides new insights into the management of AIA in breast cancer survivors for increased survival and can be utilized to make evidence-based decisions regarding treatment.
C1 [Bae, Kyeore] Doban Hosp, Integrat Canc Ctr, Seoul 03170, South Korea.
   [Bae, Kyeore; Lamoury, Gillian; Carroll, Susan; Morgia, Marita; Baron-Hay, Sally; Oh, Byeongsang] Royal North Shore Hosp, Northern Sydney Canc Ctr, Sydney, NSW 2065, Australia.
   [Lamoury, Gillian; Carroll, Susan; Baron-Hay, Sally; Oh, Byeongsang] Univ Sydney, Fac Med & Hlth, Sydney, NSW 2006, Australia.
   [Lim, Stephanie] Macarthur Canc Therapy Ctr, Med Oncol Dept, Campbelltown, NSW 2560, Australia.
   [Lim, Stephanie] Western Sydney Univ, Campbelltown, NSW 2560, Australia.
   [Shin, In-Soo] Dongguk Univ, Dept Grad Sch Educ, Seoul 04620, South Korea.
   [Park, So-Jung] Pusan Natl Univ, Korean Med Hosp, Dept Internal Med, Yangsan 50612, Gyeongnam, South Korea.
   [Oh, Byeongsang] Royal North Shore Hosp, Northern Sydney Canc Ctr, Sydney, NSW, Australia.
   [Oh, Byeongsang] Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia.
C3 Royal North Shore Hospital; University of Sydney; University of Sydney;
   University of Sydney; Western Sydney University; Dongguk University;
   Pusan National University; University of Sydney; Royal North Shore
   Hospital; University of Sydney
RP Oh, B (corresponding author), Royal North Shore Hosp, Northern Sydney Canc Ctr, Sydney, NSW, Australia.; Oh, B (corresponding author), Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia.
EM kyeorebae@gmail.com; Gillian.Lamoury@health.nsw.gov.au;
   Susan.Carroll@health.nsw.gov.au; Marita.Morgia@health.nsw.gov.au;
   Stephanie.Lim@health.nsw.gov.au; sbaronha@med.usyd.edu.au;
   9065031@daum.net; vivies@hanmail.net; byeong.oh@sydney.edu.au
RI ; Oh, Byeongsang/ABH-1460-2020
OI Lamoury, Gillian/0000-0001-9290-0193; Bae, Kyeore/0000-0002-8596-8293;
   Oh, Byeongsang/0000-0002-7204-6716
FU  [MIMIC2019-RS07]
FX This research was supported by a grant of the Research Supporting
   Program, MIMICUS Inc. (MIMIC2019-RS07) . The funders had no role in
   study design, investigation of data, statistical analyses,
   interpretation of data, and preparation of the manuscript.
CR Amandusson Å, 1999, PAIN, V83, P243, DOI 10.1016/S0304-3959(99)00109-8
   Bae K, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-033461
   Baglia ML, 2019, CANCER-AM CANCER SOC, V125, P2262, DOI 10.1002/cncr.32051
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Beckwée D, 2017, SUPPORT CARE CANCER, V25, P1673, DOI 10.1007/s00520-017-3613-z
   Blok EJ, 2018, JNCI-J NATL CANCER I, V110, DOI 10.1093/jnci/djx134
   Borenstein M, 2009, Introduction to Meta-Analysis, P217, DOI DOI 10.1002/9780470743386.CH23
   Burstein H.J., 2019, THE J
   Calder PC, 2017, BIOCHEM SOC T, V45, P1105, DOI 10.1042/BST20160474
   Cathcart-Rake E, 2021, SUPPORT CARE CANCER, V29, P387, DOI 10.1007/s00520-020-05473-2
   Chan A, 2017, SUPPORT CARE CANCER, V25, P3785, DOI 10.1007/s00520-017-3810-9
   Chim K, 2013, BMC CANCER, V13, DOI 10.1186/1471-2407-13-401
   Coleman RE, 2008, CANCER TREAT REV, V34, P275, DOI 10.1016/j.ctrv.2007.10.004
   Conejo I, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2236-3
   Crew K.D., 2010, J CLIN ONCOL OFF J A, V28
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Donovitz G, 2021, EUR J BREAST HEALTH, V17, P150, DOI 10.4274/ejbh.galenos.2021.6213
   Ernst A, 2021, CLIN BREAST CANCER, V21, pE38, DOI 10.1016/j.clbc.2020.07.008
   Fields J, 2016, J PAIN SYMPTOM MANAG, V52, P548, DOI 10.1016/j.jpainsymman.2016.03.010
   FOLLMANN D, 1992, J CLIN EPIDEMIOL, V45, P769, DOI 10.1016/0895-4356(92)90054-Q
   Geneen LJ, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011279.pub3
   Glaser R, 2015, MATURITAS, V82, P291, DOI 10.1016/j.maturitas.2015.06.002
   Glaser R, 2021, Androgens Clinical Research and Therapeutics, V2, P94, DOI [10.1089/andro.2021.0003, 10.1089/andro.2021.0003, DOI 10.1089/ANDRO.2021.0003]
   Glaser RL, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-6457-8
   Gnant M, 2021, NEW ENGL J MED, V385, P395, DOI 10.1056/NEJMoa2104162
   Goss PE, 2016, NEW ENGL J MED, V375, P209, DOI 10.1056/NEJMoa1604700
   Gregori D, 2018, JAMA-J AM MED ASSOC, V320, P2564, DOI 10.1001/jama.2018.19319
   Gupta A, 2020, JCO ONCOL PRACT, V16, P733, DOI 10.1200/OP.20.00113
   Guyatt GH, 2008, BRIT MED J, V336, P924, DOI 10.1136/bmj.39489.470347.AD
   Henry NL, 2008, BREAST CANCER RES TR, V111, P365, DOI 10.1007/s10549-007-9774-6
   Henry NL, 2019, CANCER-AM CANCER SOC, V125, P2123, DOI 10.1002/cncr.32024
   Henry NL, 2018, J CLIN ONCOL, V36, P326, DOI 10.1200/JCO.2017.74.6651
   Hershman DL, 2015, J CLIN ONCOL, V33, P1910, DOI 10.1200/JCO.2014.59.5595
   Hershman DL, 2011, BREAST CANCER RES TR, V126, P529, DOI 10.1007/s10549-010-1132-4
   Hozo S., 2005, BMC MED RES METHODOL, V5, P13, DOI [DOI 10.1186/1471-2288-5-13, 10.1186/1471-2288-5-13, DOI 10.1186/1471-2288-5-13)]
   Hróbjartsson A, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003974.pub3
   Hutton B, 2015, ANN INTERN MED, V162, P777, DOI 10.7326/M14-2385
   Jonat W, 2006, LANCET ONCOL, V7, P991, DOI 10.1016/S1470-2045(06)70948-2
   Key TJ, 2013, LANCET ONCOL, V14, P1009, DOI 10.1016/S1470-2045(13)70301-2
   Kim TH, 2018, MATURITAS, V118, P29, DOI 10.1016/j.maturitas.2018.09.005
   Lee YH, 2016, RHEUMATOL INT, V36, P663, DOI 10.1007/s00296-016-3468-5
   Li F., 2015, THE J
   Li FS, 2017, NAT PLANTS, V3, DOI 10.1038/nplants.2017.109
   Li XX, 2017, PAIN PHYSICIAN, V20, pE882
   Lim Tiaw-Kee, 2018, Medicines (Basel), V5, DOI [10.3390/medicines5030063, 10.3390/medicines5030063]
   Liu SB, 2021, NATURE, V598, P641, DOI 10.1038/s41586-021-04001-4
   López-López JAL, 2018, RES SYNTH METHODS, V9, P336, DOI 10.1002/jrsm.1310
   Lu G, 2004, STAT MED, V23, P3105, DOI 10.1002/sim.1875
   Lund Irene, 2006, Acupunct Med, V24, P13
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Nasser Mona, 2020, AM J PUBLIC HEALTH, V110, P753, DOI [10.2105/AJPH.2020.305609, DOI 10.2105/AJPH.2020.305609]
   Nekovarova T, 2014, FRONT BEHAV NEUROSCI, V8, DOI 10.3389/fnbeh.2014.00099
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Peng N, 2018, BREAST, V37, P18, DOI 10.1016/j.breast.2017.08.003
   Pfeilschifter J, 2002, ENDOCR REV, V23, P90, DOI 10.1210/er.23.1.90
   Prieto-Alhambra D, 2012, BREAST CANCER RES TR, V133, P1159, DOI 10.1007/s10549-012-2013-9
   Puhan MA, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g5630
   Rastelli AL, 2011, BREAST CANCER RES TR, V129, P107, DOI 10.1007/s10549-011-1644-6
   Romero SAD, 2020, BREAST, V49, P48, DOI 10.1016/j.breast.2019.10.008
   Rudroju N, 2013, PAIN PHYSICIAN, V16, pE705
   Rücker G, 2015, BMC MED RES METHODOL, V15, DOI 10.1186/s12874-015-0060-8
   Schwarzer Guido, 2024, CRAN
   Shapiro AC, 2016, BREAST CANCER RES TR, V155, P501, DOI 10.1007/s10549-016-3710-6
   Shenouda M., 2021, CLIN BREAST CANCER, DOI [10.1016/j.clbc.2021, DOI 10.1016/J.CLBC.2021]
   Sordi R., 2019, J NAT REM
   Stagg NJ, 2011, ANESTHESIOLOGY, V114, P940, DOI 10.1097/ALN.0b013e318210f880
   Sterne JAC, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l4898
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Tenti S, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21165625
   Tin ST, 2021, BRIT J CANCER, V125, P126, DOI 10.1038/s41416-021-01392-z
   Traish A, 2018, J CLIN MED, V7, DOI 10.3390/jcm7120549
   Tripkovic L, 2012, AM J CLIN NUTR, V95, P1357, DOI 10.3945/ajcn.111.031070
   Tsai CL, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-94466-0
   Tufanaru C, 2015, INT J EVID-BASED HEA, V13, P196, DOI 10.1097/XEB.0000000000000065
   Villaggio B, 2012, CLIN EXP RHEUMATOL, V30, P934
   Xu ZJ, 2020, BRIT J NUTR, V123, P84, DOI 10.1017/S0007114519002290
   Younus J, 2010, CURR ONCOL, V17, P87
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
NR 79
TC 9
Z9 14
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1040-8428
EI 1879-0461
J9 CRIT REV ONCOL HEMAT
JI Crit. Rev. Oncol./Hematol.
PD JAN
PY 2023
VL 181
AR 103898
DI 10.1016/j.critrevonc.2022.103898
EA DEC 2022
PG 10
WC Oncology; Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Hematology
GA G6AL6
UT WOS:000989961200001
PM 36535489
DA 2026-01-16
ER

PT J
AU Jeong, YJ
   Park, YY
   Park, KK
   Choi, YH
   Kim, CH
   Chang, YC
AF Jeong, Yun-Jeong
   Park, Yoon-Yub
   Park, Kwan-Kyu
   Choi, Yung Hyun
   Kim, Cheorl-Ho
   Chang, Young-Chae
TI Bee Venom Suppresses EGF-Induced Epithelial-Mesenchymal Transition and
   Tumor Invasion in Lung Cancer Cells
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Bee Venom; Epithelial-Mesenchymal Transition; Invasion; Melittin; Apamin
ID DOWN-REGULATION; METASTASIS; GROWTH; PROMOTES; EMT; ACTIVATION;
   ACUPUNCTURE; SENSITIVITY; EXPRESSION; RECEPTORS
AB Bee venom of Apis mellifera is a traditional medicine in Asia. It has been used with promoting results for the treatment of pain, rheumatoid, and cancer disease. The purpose of this study was to investigate the effects of bee venom on epidermal growth factor (EGF)-induced epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) and determine possible signaling pathway affected in EGF-induced EMT in A549 cells. Bee venom inhibited EGF-induced F-actin reorganization and cell invasion, and suppressed EGF-induced EMT, processes associated with tumor metastasis in NSCLC. Bee venom enhanced the upregulation of E-cadherin and the downregulation of vimentin and inhibited EGF-induced ERK, JNK, FAK, and mTOR phosphorylation in A549 cells. However, the inhibition of JNK phosphorylation by bee venom was not related to the inhibitory effects of EMT. Furthermore, we found that bee venom suppressed the EMT-related transcription factors ZEB2 and Slug by blocking EGF-induced ERK, FAK and mTOR phosphorylation. Bee venom inhibits EGF-induced EMT by blocking the phosphorylation of ERK, FAK, and mTOR, resulting in the suppression of ZEB2 and Slug. These data suggest bee venom as a potential antimetastatic agent for NSCLC.
C1 [Jeong, Yun-Jeong; Park, Yoon-Yub; Park, Kwan-Kyu; Chang, Young-Chae] Catholic Univ, Res Inst Biomed Engn, Daegu Sch Med, Daegu 42472, South Korea.
   [Jeong, Yun-Jeong; Park, Yoon-Yub; Park, Kwan-Kyu; Chang, Young-Chae] Catholic Univ, Dept Med, Daegu Sch Med, Daegu 42472, South Korea.
   [Choi, Yung Hyun] Dong Eui Univ, Dept Biochem, Coll Korean Med, Busan 47227, South Korea.
   [Kim, Cheorl-Ho] Sungkyunkwan Univ, Dept Biol Sci, Suwon 16419, Kyunggi Do, South Korea.
C3 Catholic University of Daegu; Catholic University of Daegu; Dong-Eui
   University; Sungkyunkwan University (SKKU)
RP Chang, YC (corresponding author), Catholic Univ, Daegu Sch Med, Dept Cell Biol, 3056-6,Daemyung 4 Dong, Daegu 42472, South Korea.
EM ycchang@cu.ac.kr
RI Kim, Cheorl-Ho/T-6753-2019
OI Kim, Cheorl-Ho/0000-0002-6323-0714
FU National Research Foundation of Korea (NRF) - Korean government (MSIT)
   [NRF-2017R1A2B4005937, NRF-2018R1C1B6008908]
FX This work was supported by National Research Foundation of Korea (NRF)
   grant funded by the Korean government (MSIT) (No. NRF-2017R1A2B4005937)
   and National Research Foundation of Korea (NRF) grant funded by the
   Korean government (MSIT) (No. NRF-2018R1C1B6008908).
CR Al Dayel Fouad, 2012, J Infect Public Health, V5 Suppl 1, pS31, DOI 10.1016/j.jiph.2012.09.008
   Alqutub AN, 2011, WORLD J HEPATOL, V3, P268, DOI 10.4254/wjh.v3.i10.268
   BILLINGHAM ME, 1973, NATURE, V245, P163, DOI 10.1038/245163a0
   Buonato JM, 2014, CANCER RES, V74, P309, DOI 10.1158/0008-5472.CAN-12-4721
   Cheng JC, 2012, J CLIN ENDOCR METAB, V97, pE1380, DOI 10.1210/jc.2011-2751
   Cho HJ, 2010, J ETHNOPHARMACOL, V127, P662, DOI 10.1016/j.jep.2009.12.007
   Cho SY, 2018, J ALTERN COMPLEM MED, V24, P25, DOI 10.1089/acm.2016.0250
   Constanzo JD, 2016, NEOPLASIA, V18, P282, DOI 10.1016/j.neo.2016.03.003
   Gu H., 2018, MOL MED REP
   Gulhati P, 2011, CANCER RES, V71, P3246, DOI 10.1158/0008-5472.CAN-10-4058
   Han SM, 2012, TOX RESEARCH, V28, P99, DOI 10.5487/TR.2012.28.2.099
   Herbst RS, 2003, CLIN CANCER RES, V9, P5813
   Jeong JH, 2010, MOL CANCER THER, V9, P2102, DOI 10.1158/1535-7163.MCT-09-1159
   Jeong YJ, 2014, FOOD CHEM TOXICOL, V68, P218, DOI 10.1016/j.fct.2014.03.022
   Jin YJ, 2014, INT J CANCER, V134, P2294, DOI 10.1002/ijc.28568
   Kalluri R, 2009, J CLIN INVEST, V119, P1420, DOI 10.1172/JCI39104
   Kim GT, 2014, INT J ONCOL, V45, P1673, DOI 10.3892/ijo.2014.2546
   Kwon YB, 2001, PAIN, V90, P271, DOI 10.1016/S0304-3959(00)00412-7
   Lee SH., 2003, Journal of Acupuncture Research, V20, P80
   Lee WR, 2015, TOXINS, V7, P4758, DOI 10.3390/toxins7114758
   Lee WR, 2014, BIOCHEM BIOPH RES CO, V450, P195, DOI 10.1016/j.bbrc.2014.05.089
   Li YR, 2017, BIOMED PHARMACOTHER, V92, P140, DOI 10.1016/j.biopha.2017.05.058
   Li YW, 2016, CANCER BIOL THER, V17, P272, DOI 10.1080/15384047.2016.1139242
   Liu CC, 2016, CANCER CHEMOTH PHARM, V78, P1113, DOI 10.1007/s00280-016-3160-1
   Liu F, 2017, EUR J PHARMACOL, V811, P180, DOI 10.1016/j.ejphar.2017.05.040
   Nabeshima K, 2002, PATHOL INT, V52, P255, DOI 10.1046/j.1440-1827.2002.01343.x
   Park J, 2018, ANN DERMATOL, V30, P202, DOI 10.5021/ad.2018.30.2.202
   Park JY, 2017, TOXINS, V9, DOI 10.3390/toxins9100319
   Puisieux A, 2014, NAT CELL BIOL, V16, P488, DOI 10.1038/ncb2976
   Radisky DC, 2005, J CELL SCI, V118, P4325, DOI 10.1242/jcs.02552
   Ridley AJ, 2003, SCIENCE, V302, P1704, DOI 10.1126/science.1092053
   Saintigny P, 2012, DISCOV MED, V13, P287
   Shi ZM, 2017, ONCOGENE, V36, P2577, DOI 10.1038/onc.2016.414
   Shin SH, 2018, MOL MED REP, V17, P6632, DOI 10.3892/mmr.2018.8720
   Shintani Y, 2011, ANN THORAC SURG, V92, P1794, DOI 10.1016/j.athoracsur.2011.07.032
   Son DJ, 2007, PHARMACOL THERAPEUT, V115, P246, DOI 10.1016/j.pharmthera.2007.04.004
   Tang J, 2003, BIOCHEM BIOPH RES CO, V312, P930, DOI 10.1016/j.bbrc.2003.11.016
   Tashiro E, 2016, BIOCHEM BIOPH RES CO, V477, P801, DOI 10.1016/j.bbrc.2016.06.138
   VEALE D, 1987, BRIT J CANCER, V55, P513, DOI 10.1038/bjc.1987.104
   Wells A, 1999, INT J BIOCHEM CELL B, V31, P637, DOI 10.1016/S1357-2725(99)00015-1
   Wendt MK, 2010, ONCOGENE, V29, P6485, DOI 10.1038/onc.2010.377
   Xu QL, 2017, ONCOTARGET, V8, P9557, DOI 10.18632/oncotarget.13771
   Zheng J, 2015, ONCOTARGET, V6, P44437, DOI 10.18632/oncotarget.6295
NR 43
TC 20
Z9 26
U1 1
U2 23
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2019
VL 47
IS 8
BP 1869
EP 1883
DI 10.1142/S0192415X19500952
PG 15
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA JW4GJ
UT WOS:000503011400011
PM 31786944
DA 2026-01-16
ER

PT J
AU Liu, HP
   Ma, YB
   Liu, J
   Guo, ZX
   Yan, WJ
   Wen, SQ
   Zhao, Q
   Guo, XR
   Zhang, XY
   Sheng, Q
AF Liu, Haipeng
   Ma, Yabing
   Liu, Juan
   Guo, Zhaoxia
   Yan, Wenjun
   Wen, Shiqi
   Zhao, Qiong
   Guo, Xiaoru
   Zhang, Xiaoyan
   Sheng, Qing
TI Therapeutic effect of electroacupuncture on rats with neuropathic pain
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Acupuncture; neuropathic pain; CX3CRI protein
ID FRACTALKINE RECEPTOR CX3CR1; DORSAL-ROOT GANGLIA; SPINAL-CORD;
   UP-REGULATION; MOUSE MODEL; TNF-ALPHA; IL-6; EXPRESSION; DRUG
AB Objective: To study the therapeutic effect and possible mechanism of electroacupuncture on rats with neuropathic pain (NP). Methods: A total of 30 Sprague Dawley rats were randomized into three groups, group A (n=10), group B (n=10), and group C (n=10). In group A, a chronic constriction injury (CCI) model of NP was induced by loosely making four ligations at the mid-thigh level of the right sciatic nerve of rats with 4-0 chromic catgut, and electroacupuncture was used at day 1, day 4 and day 7 after surgery respectively as the treatment of NP. In group B, the CCI model was also induced and no treatment was given. In group C, the same surgery was made without tying the sciatic nerve. The thermal and mechanical pain thresholds of each rat before surgery and from day 1 to 7 after surgery were recorded and compared. The rats were sacrificed on day 8 after surgery and underwent perfusion-fixation for the removal of spinal cord. Western blot was used to detect the expression of CX3CR1 protein in the spinal cord. Enzyme-linked immunosorbent assay was used to measure the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin 6 (IL-6) in the spinal cord. Results: In group A, mechanical withdrawal thresholds (MWT) and paw withdrawal latency (PWL) of right hind paw on day 1-3 after surgery were significantly lower than those before surgery (P<0.05); MWT and PWL were significantly higher on day 4-7 after surgery than those on day 3 after surgery (P<0.05), but were still lower than the preoperative levels (P<0.05). In group B, MWT and PWL of right hind paw on day 1-7 after surgery were significantly lower than those before surgery (P<0.05). There were no significant differences in MWT and PWL of right hind paw between group A and group B on day 1-3 after surgery (P>0.05). MWT and PWL in group A were significantly higher than those in group B on day 4-7 after surgery (P<0.05). Compared with the preoperative levels, there were no significant differences in MWT and PWL in group C after surgery (P>0.05). Compared with those in group C, MWT and PWL of right hind paw in group A and group B declined significantly after surgery (all P<0.05); In group A and group B, no significant differences were found in MWT and PWL of left hind paw before and after surgery (all P>0.05). The expression of CX3CR1 protein was significantly increased in group A and group B compared with that in group C (all P<0.05), and the expression of CX3CR1 protein in group A was significantly lower than that in group B (P<0.05). The levels of TNF-alpha, IL-1 beta and IL-6 in group A and group B were significantly higher compared with those in group C (P<0.05). The levels of TNF-alpha, IL-1 beta and IL-6 in group A were significantly lower than those in group B (all P<0.05). Conclusion: The thermal and mechanical pain thresholds of CCI rats decrease significantly. Electroacupuncture can significantly relieve pain and increase pain threshold. The development of NP may be associated with the increase of the expression of CX3CR1 protein and the levels of inflammatory factors in the spinal cord, including TNF-alpha, IL-1 beta and IL-6. The mechanism of electroacupuncture as a treatment for NP may be related to the reduction of the expression of CX3CR1 protein and the levels of inflammatory factors.
C1 [Liu, Haipeng; Ma, Yabing; Guo, Xiaoru; Zhang, Xiaoyan; Sheng, Qing] Gansu Prov Hosp, Dept Pain, Lanzhou, Gansu, Peoples R China.
   [Liu, Juan] Gansu Prov Hosp, Dept Outpatient, Lanzhou, Gansu, Peoples R China.
   [Guo, Zhaoxia] Gansu Prov Hosp, Dept Cardiol, Lanzhou, Gansu, Peoples R China.
   [Yan, Wenjun] Gansu Prov Hosp, Dept Anesthesiol, Lanzhou, Gansu, Peoples R China.
   [Wen, Shiqi] Gansu Prov Hosp, Dept Vasc Surg, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
   [Zhao, Qiong] Tianshui Combine Tradit Chinese & Western Med Hos, Dept Oral & Maxillofacial Surg, Tianshui, Gansu, Peoples R China.
RP Wen, SQ (corresponding author), Gansu Prov Hosp, Dept Vasc Surg, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
EM wenshiqi73@163.com
RI Yan, WenJun/KIC-5682-2024; Guo, Xiaoru/D-8459-2013
FU Gansu Health Industry Research Program [GSWKY2017-52]
FX This article is supported by Gansu Health Industry Research Program
   (GSWKY2017-52).
CR Al-Mazidi S, 2018, EUR J PAIN, V22, P810, DOI 10.1002/ejp.1169
   [Anonymous], 2012, Drug Ther Bull, V50, P126, DOI 10.1136/dtb.2012.11.0139
   Baron R, 2017, PAIN, V158, P261, DOI 10.1097/j.pain.0000000000000753
   Barragán-Iglesias P, 2018, PHARMACOL REP, V70, P294, DOI 10.1016/j.pharep.2017.09.002
   BOUREAU F, 1978, ANN ANESTHESIOL FR, V19, P422
   Brázda V, 2013, MOL PAIN, V9, DOI 10.1186/1744-8069-9-42
   Bura AS, 2013, EUR J PAIN, V17, P832, DOI 10.1002/j.1532-2149.2012.00251.x
   Clark AK, 2014, FRONT CELL NEUROSCI, V8, DOI 10.3389/fncel.2014.00121
   Dubovy P, 2010, NEURON GLIA BIOL, V6, P73, DOI 10.1017/S1740925X10000074
   Gopalsamy B, 2017, J PAIN RES, V10, P2605, DOI 10.2147/JPR.S143024
   Guo JR, 2017, ONCOTARGET, V8, P52923, DOI 10.18632/oncotarget.17629
   Huang PC, 2017, ANESTH ANALG, V124, P2038, DOI 10.1213/ANE.0000000000001600
   Laumet G, 2017, BRAIN BEHAV IMMUN, V66, P94, DOI 10.1016/j.bbi.2017.07.008
   Li Qiu-Yue, 2017, Zhongguo Zhong Yao Za Zhi, V42, P3709, DOI 10.19540/j.cnki.cjcmm.20170907.004
   Li WJ, 2012, NEUROCHEM INT, V61, P1397, DOI 10.1016/j.neuint.2012.10.002
   Lindia JA, 2005, J PAIN, V6, P434, DOI 10.1016/j.jpain.2005.02.001
   Liu HC, 2012, ARTIF CELL BLOOD SUB, V40, P331, DOI 10.3109/10731199.2012.659350
   Lu Bo, 2013, Zhonghua Yi Xue Za Zhi, V93, P1997
   Mah W, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13561-3
   Notartomaso S, 2017, MOL PAIN, V13, DOI 10.1177/1744806917697009
   Pexton T, 2011, EXPERT OPIN INV DRUG, V20, P1277, DOI 10.1517/13543784.2011.600686
   Romundstad L, 2006, PAIN, V124, P92, DOI 10.1016/j.pain.2006.03.020
   Staniland AA, 2010, J NEUROCHEM, V114, P1143, DOI 10.1111/j.1471-4159.2010.06837.x
   Wang J, 2017, MOL PAIN, V13, DOI 10.1177/1744806917746564
   Wang XL, 2017, J PHARMACOL SCI, V135, P141, DOI 10.1016/j.jphs.2017.08.007
   Wei XH, 2013, EXP NEUROL, V241, P159, DOI 10.1016/j.expneurol.2012.12.007
   Zhao WX, 2017, MOL MED REP, V16, P1559, DOI 10.3892/mmr.2017.6723
   Zheng Jinwei, 2011, Zhongguo Zhong Yao Za Zhi, V36, P2552
   Zhu WJ, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/480702
NR 29
TC 1
Z9 1
U1 0
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2019
VL 12
IS 7
BP 8531
EP 8539
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IM4UR
UT WOS:000477991300063
DA 2026-01-16
ER

PT J
AU Han, XR
   Yue, W
   Chen, HC
   He, W
   Chen, SX
   Liu, N
   Yang, M
AF Han, Xin-rui
   Yue, Wei
   Chen, Hui-chao
   He, Wei
   Chen, Shan-xia
   Liu, Na
   Yang, Ming
TI Treatment duration of wrist-ankle acupuncture for relieving
   post-thyroidectomy pain: A randomized controlled trial
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Article
DE Thyroidectomy; Thyroid tumor; Wrist -ankle acupuncture; Post -operative
   pain; Randomized controlled trial
ID POSTOPERATIVE PAIN; ASSOCIATION GUIDELINES; MANAGEMENT; CANCER; NAUSEA
AB Background: Treatment duration of wrist-ankle acupuncture (WAA) is uncertain for post-thyroidectomy pain relief.Objective: This study evaluated the effect of different WAA treatment duration on post-operative pain relief and other discomforts associated with thyroidectomy. Design, setting, participants and intervention: This randomized controlled trial was conducted at a single research site in Guangzhou, China. A total of 132 patients receiving thyroidectomy were randomly divided into the control group (sham WAA, 30 min) and three intervention groups (group 1: WAA, 30 min; group 2: WAA, 45 min; group 3: WAA, 60 min), with group allocation ratio of 1:1:1:1. Acupuncture was administered within 1 hour of leaving the operating room. Outcomes and measures: Primary outcome was patients' pain at the surgical site assessed by visual analogue scale (VAS) at the moment after acupuncture treatment (post-intervention). Secondary outcomes included the patients' pain VAS scores at 6, 12, 24, 48 and 72 h after the thyroidectomy, the 40-item Quality of Recovery (QoR-40) score, the grade of post-operative nausea and vomiting (PONV), and the use of additional analgesic therapy. Results: The adjusted mean difference (AMD) in VAS scores from baseline to post-intervention in group 1 was -0.89 (95% confidence interval [CI], -1.02 to -0.76). The decrease in VAS score at post-intervention was statistically significant in group 1 compared to the control group (AMD, -0.43; 95% CI, -0.58 to -0.28; P < 0.001), and in groups 2 and 3 compared to group 1 (group 2 vs group 1: AMD, -0.65; 95% CI, -0.81 to -0.48; P < 0.001; group 3 vs group 1: AMD, -0.66; 95% CI, -0.86 to -0.47; P < 0.001). The VAS scores in the four groups converged beyond 24 h after the operation. Fewer patients in group 2 and group 3 experienced PONV in the first 24 h after operation. No statistical differences were measured in QoR-40 score and the number of patients with additional analgesic therapy.Conclusion: Compared with the 30 min intervention, WAA treatment with longer needle retention time (45 or 60 min) had an advantage in pain relief within 6 h after surgery. WAA's analgesic effect lasted for 6-12 h post-operatively. Please cite this article as: Han XR, Yue W, Chen HC, He W, Luo JH, Chen SX, Liu N, Yang M. Treatment duration of wrist-ankle acupuncture for relieving post-thyroidectomy pain: A randomized controlled trial. J Integr Med. 2023; 21(2): 168-175. (c) 2023 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. All rights reserved.
C1 [Han, Xin-rui] Chengdu Integrated TCM & Western Med Hosp, Dept Nursing, Chengdu 610041, Sichuan, Peoples R China.
   [Yue, Wei; Chen, Shan-xia; Liu, Na; Yang, Ming] Guangzhou Univ Chinese Med, Sch Nursing, Guangzhou 510006, Guangdong, Peoples R China.
   [Chen, Hui-chao] Guangdong Prov Hosp Tradit Chinese Med, Dept Nursing, Guangzhou 510120, Guangdong, Peoples R China.
   [He, Wei] Guangdong Prov Hosp Tradit Chinese Med, Dept Gen Surg, Guangzhou 510120, Guangdong, Peoples R China.
   [He, Wei] Guangzhou Women & Childrens Med Ctr, Dept Gynecol & Obstet, Guangzhou 510120, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine
RP Yang, M (corresponding author), Guangzhou Univ Chinese Med, Sch Nursing, Guangzhou 510006, Guangdong, Peoples R China.
EM hlym@gzucm.edu.cn
RI 陈, 霞/GPP-3614-2022; 韩, 欣芮/IYS-4390-2023
FU Postgraduate Education Innovation Program in Guangdong Province
   [2022SFKC030]; Humanities and Social Sciences Program in Guangzhou
   University of Chinese Medicine [2021SKYB08]; Teaching Quality and
   Teaching Reform Program in Guangzhou University of Chinese Medicine
   (GZUCM Office [2021]) [323]
FX This work was supported by Postgraduate Education Innovation Program in
   Guangdong Province (No. 2022SFKC030), Humanities and Social Sciences
   Program in Guangzhou University of Chinese Medicine (No. 2021SKYB08),
   and Teaching Quality and Teaching Reform Program in Guangzhou University
   of Chinese Medicine (GZUCM Office [2021] No. 323).
CR [Anonymous], 2012, SPSS STAT WIND, DOI DOI 10.1111/B.9781444331899.2011.00023.X
   [Anonymous], 2010, BMJ-BRIT MED J, V340, DOI DOI 10.1136/BMJ.C332
   Brummett CM, 2019, J MANAG CARE SPEC PH, V25, P973, DOI 10.18553/jmcp.2019.19055
   Chen Y, 2019, CHIN J HOSP PHARM, V39, P2245, DOI DOI 10.13286/j.cnki.chinhosppharmacyj.2019.22.01
   Chen YF, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1923-9
   Chou R, 2016, J PAIN, V17, P131, DOI 10.1016/j.jpain.2015.12.008
   Desu M.M., 1990, SAMPLE SIZE METHODOL
   Dhillon VK, 2020, OTOLARYNG CLIN N AM, V53, P779, DOI 10.1016/j.otc.2020.05.007
   Ferlay J, 2010, BREAST CANCER EPIDEMIOLOGY, P1, DOI 10.1007/978-1-4419-0685-4_1
   Ferrell JK, 2021, HEAD NECK-J SCI SPEC, V43, P2281, DOI 10.1002/hed.26774
   Fitzmaurice C, 2019, JAMA ONCOL, V5, P1749, DOI 10.1001/jamaoncol.2019.2996
   Gan TJ, 2014, ANESTH ANALG, V118, P85, DOI 10.1213/ANE.0000000000000002
   Gornall BF, 2013, BRIT J ANAESTH, V111, P161, DOI 10.1093/bja/aet014
   Haugen BR, 2016, THYROID, V26, P1, DOI 10.1089/thy.2015.0020
   Heikkinen M, 2021, WORLD J SURG, V45, P765, DOI 10.1007/s00268-020-05863-x
   [胡侠 Hu Xia], 2004, [中国针灸, Chinese Acupuncture and Moxibustion], V24, P361
   Jiang X, 2004, ZHONGGUO ZHONG YI JI, V10, P76
   Kraus WE, 2019, LANCET DIABETES ENDO, V7, P673, DOI 10.1016/S2213-8587(19)30151-2
   Lao HH, 1999, WRIST ANKLE ACUPUNCT, V2nd
   Le May M, 2021, JAMA-J AM MED ASSOC, V326, P1494, DOI 10.1001/jama.2021.15703
   Li Y, 2020, WORLD J ACUPUNCT-MOX, V30, P183, DOI 10.1016/j.wjam.2020.05.007
   Lim Hoi Jeong, 2004, J Prev Med Public Health, V37, P381
   Liu Wei-Ting, 2020, Zhen Ci Yan Jiu, V45, P623, DOI 10.13702/j.1000-0607.190794
   Lu IC, 2017, GLAND SURG, V6, P469, DOI 10.21037/gs.2017.05.02
   MacPherson Hugh, 2010, J Evid Based Med, V3, P140, DOI 10.1111/j.1756-5391.2010.01086.x
   Mitra S, 2018, CURR PAIN HEADACHE R, V22, DOI 10.1007/s11916-018-0690-8
   Myles PS, 2017, BRIT J ANAESTH, V118, P424, DOI 10.1093/bja/aew466
   PASS 15, 2017, PASS 15 Power Analysis and Sample Size Software
   Patel KN, 2020, ANN SURG, V271, pE21, DOI 10.1097/SLA.0000000000003580
   Roberts C, 2021, STAT MED, V40, P349, DOI 10.1002/sim.8778
   Ross DS, 2016, THYROID, V26, P1343, DOI 10.1089/thy.2016.0229
   Shindo M, 2018, JAMA OTOLARYNGOL, V144, P1098, DOI 10.1001/jamaoto.2018.2427
   Siu PM, 2021, ANN INTERN MED, V174, P1050, DOI 10.7326/M20-7014
   Standardization Work Committee of Chinese Acupuncture and Moxibustion Society, 2009, 21709192009 GBT STAN, P2
   Tharakan T, 2019, OTOLARYNG HEAD NECK, V160, P394, DOI 10.1177/0194599818797574
   Uhlmann RA, 2019, J SURG RES, V241, P107, DOI 10.1016/j.jss.2019.03.050
   Vas J, 2006, PAIN, V126, P245, DOI 10.1016/j.pain.2006.07.002
   Vignaud M, 2021, ANAESTH CRIT CARE PA, V40, DOI 10.1016/j.accpm.2021.100822
   Ware JH, 2012, NEW ENGL J MED, V367, P1353, DOI 10.1056/NEJMsm1210043
   Wu Qiu-Lan, 2019, Zhongguo Zhen Jiu, V39, P1051, DOI 10.13703/j.0255-2930.2019.10.005
   Xian XJ, 1995, LIAONING ZHONG YI ZA, V22, P182
   Xu LP, 2020, COMPLEMENT THER CLIN, V39, DOI 10.1016/j.ctcp.2020.101170
   Yang MX, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170952
   Ye QH, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01709
   Zeng K, 2014, AM J CHINESE MED, V42, P289, DOI 10.1142/S0192415X14500190
   Zhai SJ, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019496
   Zhang CP, 2020, CHIN MED-UK, V15, DOI 10.1186/s13020-020-0289-y
   Zhang X, 1991, J CHIN MED, V37, P5
   Zhao L, 2019, JAMA INTERN MED, V179, P1388, DOI 10.1001/jamainternmed.2019.2407
   Zhu LB, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/261709
NR 50
TC 8
Z9 11
U1 1
U2 28
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD MAR
PY 2023
VL 21
IS 2
BP 168
EP 175
DI 10.1016/j.joim.2023.02.001
EA MAR 2023
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA G7TO6
UT WOS:000991140200001
PM 36841749
DA 2026-01-16
ER

PT J
AU Henry, NL
   Griggs, JJ
AF Henry, N. Lynn
   Griggs, Jennifer J.
TI The Power of the Placebo in Symptom Management
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Editorial Material
ID INHIBITOR-INDUCED ARTHRALGIA; STAGE BREAST-CANCER; CONTROLLED-TRIAL;
   DOUBLE-BLIND; RANDOMIZED-TRIAL; WOMEN; PAIN; ACUPUNCTURE; DULOXETINE;
   THERAPY
C1 [Henry, N. Lynn; Griggs, Jennifer J.] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Henry, NL (corresponding author), Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA.
OI Henry, N Lynn/0000-0002-4771-5930
CR Arnold LM, 2005, PAIN, V119, P5, DOI 10.1016/j.pain.2005.06.031
   Burstein HJ, 2007, BREAST, V16, P223, DOI 10.1016/j.breast.2007.01.011
   Burstein HJ, 2010, J CLIN ONCOL, V28, P3784, DOI 10.1200/JOP.000082
   Cherkin DC, 2009, ARCH INTERN MED, V169, P858, DOI 10.1001/archinternmed.2009.65
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Cruciani RA, 2012, J CLIN ONCOL, V30, P3864, DOI 10.1200/JCO.2011.40.2180
   Felson DT, 2005, ARTHRITIS RHEUM-US, V52, P2594, DOI 10.1002/art.21364
   Finniss DG, 2010, LANCET, V375, P686, DOI 10.1016/S0140-6736(09)61706-2
   Folkerd EJ, 2014, J CLIN ONCOL, V32, P1396, DOI 10.1200/JCO.2013.53.9411
   Gotay C, 2011, EXPERT REV PHARM OUT, V11, DOI [10.1586/ERP.11.80, 10.1586/erp.11.80]
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Henry NL, 2008, ONCOLOGY-NY, V22, P1401
   Hershman DL, 2015, J CLIN ONCOL, V33, P1910, DOI 10.1200/JCO.2014.59.5595
   Irwin ML, 2015, J CLIN ONCOL, V33, P1104, DOI 10.1200/JCO.2014.57.1547
   Kaptchuk TJ, 2008, BMJ-BRIT MED J, V336, P999, DOI 10.1136/bmj.39524.439618.25
   Kastelein JJP, 2014, J CLIN LIPIDOL, V8, P94, DOI 10.1016/j.jacl.2013.10.003
   Kong J, 2006, J NEUROSCI, V26, P381, DOI 10.1523/JNEUROSCI.3556-05.2006
   Loprinzi CL, 2009, J CLIN ONCOL, V27, P2831, DOI 10.1200/JCO.2008.19.6253
   Morales L, 2008, J CLIN ONCOL, V26, P3147, DOI 10.1200/JCO.2007.15.4005
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Peciña M, 2014, SOC COGN AFFECT NEUR, V9, P1013, DOI 10.1093/scan/nst079
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Spathis A, 2014, J CLIN ONCOL, V32, P1882, DOI 10.1200/JCO.2013.54.4346
   Zubieta JK, 2005, J NEUROSCI, V25, P7754, DOI 10.1523/JNEUROSCI.0439-05.2005
NR 24
TC 9
Z9 10
U1 0
U2 6
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD JUN 10
PY 2015
VL 33
IS 17
BP 1870
EP U21
DI 10.1200/JCO.2015.61.1004
PG 5
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA CK1WQ
UT WOS:000355999800004
PM 25940722
OA Bronze
DA 2026-01-16
ER

PT J
AU Zhi, WI
   Ingram, E
   Li, SQ
   Chen, P
   Piulson, L
   Bao, T
AF Zhi, W. Iris
   Ingram, Evan
   Li, Susan Qing
   Chen, Patricia
   Piulson, Lauren
   Bao, Ting
TI Acupuncture for Bortezomib-Induced Peripheral Neuropathy: Not Just for
   Pain
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; bortezomib; multiple myeloma; peripheral neuropathy
ID SMALL FIBER NEUROPATHY; MULTIPLE-MYELOMA; ONCOLOGY-GROUP; BREAST-CANCER;
   CHEMOTHERAPY; TRIAL; ACTIVATION; MECHANISMS; PREVENTION; RECEPTORS
AB Background: Bortezomib-induced peripheral neuropathy (BIPN) is a common and debilitating side effect. Our pilot study demonstrated that acupuncture is safe and can decrease total neuropathic symptoms. However, there is lack of knowledge in which individual BIPN symptoms benefited from acupuncture. Purpose: To characterize individual symptoms reduced by acupuncture in patients with BIPN. Methods: Patients with multiple myeloma treated with bortezomib who developed BIPN grade 2 or above, based on National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE), were enrolled and received 10 acupuncture treatments over 10 weeks. Self-reported BIPN-associated symptoms assessments were collected weekly at baseline, during, and after acupuncture treatment using the Neuropathy Pain Scale (NPS) and the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) questionnaires. Changes in individual symptoms were analyzed based on FACT/GOG-Ntx and NPS scores. Results: There were statistically significant reductions in individual symptoms in both NPS and FACT/GOG-Ntx. The FACT/GOG-Ntx reductions were most pronounced in hand/feet numbness/tingling, discomfort, and trouble walking. The sensory symptoms, such as tingling and numbness, especially in the feet, reduced the most (P < .0001), and motor dysfunction also reduced significantly (P = .0001). Both hearing and dysfunction scores were also statistically significantly increased, indicating improved symptoms. The NPS scores showed significant symptom relief in all 10 items from the NPS assessment, particularly in cold sensitivity and an unpleasant feeling. Conclusions: Acupuncture can improve multiple symptoms associated with BIPN, particularly numbness and tingling in hands and feet, cold sensitivity, and an unpleasant feeling. Further randomized control trials are warranted to confirm our findings.
C1 [Zhi, W. Iris; Li, Susan Qing; Chen, Patricia; Piulson, Lauren; Bao, Ting] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
   [Ingram, Evan] Univ Toledo, 2801 W Bancroft St, Toledo, OH 43606 USA.
C3 Memorial Sloan Kettering Cancer Center; University System of Ohio;
   University of Toledo
RP Bao, T (corresponding author), Mem Sloan Kettering Canc Ctr, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
EM baot@mskcc.org
OI Zhi, Iris/0000-0003-4263-7272; Bao, Ting/0000-0003-4437-2597; Ingram,
   Evan/0000-0002-3019-8455; Chen, Patricia A/0000-0003-2055-7562
FU Memorial Sloan Kettering Cancer Center P30 Grant [P30-CA008748]; 
   [R21CA173263]; National Cancer Institute [P30CA008748] Funding Source:
   NIH RePORTER
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was funded in part by a Memorial Sloan Kettering Cancer Center P30 Grant
   (P30-CA008748). This study was also funded in part by a R21CA173263
   (Ting Bao).
CR Abuaisha BB, 1998, DIABETES RES CLIN PR, V39, P115, DOI 10.1016/S0168-8227(97)00123-X
   Albers JW, 2014, COCHRANE DB SYST REV
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Bailey A, 2017, J ACUPUNCT MERIDIAN, V10, P90, DOI 10.1016/j.jams.2016.10.004
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Ben-Horin I, 2017, INTEGR CANCER THER, V16, P258, DOI 10.1177/1534735417690254
   Brown MRD, 2014, BRIT J PAIN, V8, P139, DOI 10.1177/2049463714542605
   Broyl A, 2010, LANCET ONCOL, V11, P1057, DOI 10.1016/S1470-2045(10)70206-0
   Calhoun EA, 2003, INT J GYNECOL CANCER, V13, P741, DOI 10.1111/j.1525-1438.2003.13603.x
   Elmariah SB, 2017, DERMATOL CLIN, V35, P373, DOI 10.1016/j.det.2017.02.011
   Farguhar-Smith P., 2016, Pain Clin Updates, V24, P8
   Gao X, 2015, NEUROGASTROENT MOTIL, V27, P1817, DOI 10.1111/nmo.12694
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Geng SJ, 2010, EXP NEUROL, V222, P256, DOI 10.1016/j.expneurol.2010.01.003
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Huang HQ, 2007, INT J GYNECOL CANCER, V17, P387, DOI 10.1111/j.1525-1438.2007.00794.x
   Jensen MP, 2006, CLIN J PAIN, V22, P97, DOI 10.1097/01.ajp.0000173018.64741.62
   Kawakita K, 2014, BIOPSYCHOSOC MED, V8, DOI 10.1186/1751-0759-8-4
   Kerckhove N, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00086
   Lin D, 2014, INT J MOL SCI, V15, P3234, DOI 10.3390/ijms15023234
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Lu ZX, 2017, J ALTERN COMPLEM MED, V23, P964, DOI 10.1089/acm.2017.0052
   Mateos MV, 2007, BEST PRACT RES CL HA, V20, P701, DOI 10.1016/j.beha.2007.09.003
   Paik S, 2006, J CLIN ONCOL, V24, P3726, DOI 10.1200/JCO.2005.04.7985
   Piccolo J, 2014, AM J HEALTH-SYST PH, V71, P19, DOI 10.2146/ajhp130126
   Potenzieri C, 2012, CLIN EXP ALLERGY, V42, P8, DOI 10.1111/j.1365-2222.2011.03791.x
   Richardson PG, 2006, J CLIN ONCOL, V24, P3113, DOI 10.1200/JCO.2005.04.7779
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Siniscalco D, 2011, CURR NEUROPHARMACOL, V9, P523, DOI 10.2174/157015911798376208
   Tavee J, 2009, CLEV CLIN J MED, V76, P297, DOI 10.3949/ccjm.76a.08070
   Voortman M, 2017, CURR OPIN PULM MED, V23, P447, DOI 10.1097/MCP.0000000000000413
   Zhang F, 2017, GASTROENT RES PRACT, V2017, DOI 10.1155/2017/5687496
   Zhou W, 2014, J ACUPUNCT MERIDIAN, V7, P186
NR 33
TC 28
Z9 37
U1 1
U2 20
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD DEC
PY 2018
VL 17
IS 4
BP 1079
EP 1086
DI 10.1177/1534735418788667
PG 8
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA HA5OG
UT WOS:000450322400008
PM 30027756
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Brown, ML
   Rojas, E
   Gouda, S
AF Brown, Melanie L.
   Rojas, Enrique
   Gouda, Suzanne
TI A Mind-Body Approach to Pediatric Pain Management
SO CHILDREN-BASEL
LA English
DT Review
DE mind-body medicine; pain management; pediatrics; acupuncture; yoga;
   meditation; hypnosis
ID MINDFULNESS MEDITATION; STRESS REDUCTION; OPIOID PRESCRIPTIONS;
   ACUPUNCTURE STIMULATION; BEHAVIORAL MEDICINE; COST-EFFECTIVENESS;
   ABDOMINAL-PAIN; LIMBIC SYSTEM; YOUNG-ADULTS; BACK-PAIN
AB Pain is a significant public health problem that affects all populations and has significant financial, physical and psychological impact. Opioid medications, once the mainstay of pain therapy across the spectrum, can be associated with significant morbidity and mortality. Centers for Disease and Control (CDC) guidelines recommend that non-opioid pain medications are preferred for chronic pain outside of certain indications (cancer, palliative and end of life care). Mindfulness, hypnosis, acupuncture and yoga are four examples of mind-body techniques that are often used in the adult population for pain and symptom management. In addition to providing significant pain relief, several studies have reported reduced use of opioid medications when mind-body therapies are implemented. Mind-body medicine is another approach that can be used in children with both acute and chronic pain to improve pain management and quality of life.
C1 [Brown, Melanie L.; Rojas, Enrique; Gouda, Suzanne] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA.
   [Brown, Melanie L.] Childrens Hosp & Clin Minnesota, Dept Pain Palliat Care & Integrat Med, Minneapolis, MN 55404 USA.
C3 University of Chicago; Children's Hospitals & Clinics of Minnesota
RP Brown, ML (corresponding author), Univ Chicago, Dept Pediat, Chicago, IL 60637 USA.; Brown, ML (corresponding author), Childrens Hosp & Clin Minnesota, Dept Pain Palliat Care & Integrat Med, Minneapolis, MN 55404 USA.
EM melanie.brown@childrensmn.org; erojas@peds.bsd.uchicago.edu;
   Suzanne.Gouda@uchospitals.edu
RI Brown, Melanie/HGB-5161-2022
OI Brown, Melanie/0000-0002-3469-7729
FU Coleman Foundation; Oberweiler Foundation; Patient-Centered Outcomes
   Research Institute (PCORI); PCORI
FX M.B. is supported in part by the Coleman Foundation, the Oberweiler
   Foundation and the Patient-Centered Outcomes Research Institute (PCORI).
   E.R. is supported in part by PCORI. The funding sponsors had no role in
   the design of the article; in the collection, analysis, or
   interpretation of information; in the writing of the manuscript, or in
   the decision to publish.
CR Adams D, 2011, PEDIATRICS, V128, pE1575, DOI 10.1542/peds.2011-1091
   Anand KJS, 2010, PEDIATRICS, V125, pE1208, DOI 10.1542/peds.2009-0489
   ANAND KJS, 1994, CRIT CARE MED, V22, P334, DOI 10.1097/00003246-199402000-00027
   ANDERSSON S, 1995, MED HYPOTHESES, V45, P271, DOI 10.1016/0306-9877(95)90117-5
   [Anonymous], CRIT CARE MED
   [Anonymous], SECTION INTEGRATIVE
   [Anonymous], JAMA
   [Anonymous], RES PRACT
   [Anonymous], ORIENTAL MED
   [Anonymous], YOG
   [Anonymous], SYSTEMATIC REV PAIN
   [Anonymous], 2015, NHPCOS FACTS FIG HOS
   Asmundson GJG, 2012, PAIN RES MANAG, V17, P397, DOI 10.1155/2012/908061
   Ball TM, 2003, CLIN PEDIATR, V42, P527, DOI 10.1177/000992280304200607
   Barnes Patricia M, 2008, Natl Health Stat Report, P1
   Biella G, 2001, NEUROIMAGE, V14, P60, DOI 10.1006/nimg.2001.0798
   Bohnert ASB, 2011, JAMA-J AM MED ASSOC, V305, P1315, DOI 10.1001/jama.2011.370
   Brands MMMG, 2011, COMPLEMENT THER MED, V19, P109, DOI 10.1016/j.ctim.2011.05.004
   Britton WB, 2014, J SCHOOL PSYCHOL, V52, P263, DOI 10.1016/j.jsp.2014.03.002
   Burke CA, 2010, J CHILD FAM STUD, V19, P133, DOI 10.1007/s10826-009-9282-x
   Carlson LE, 2008, CURR TREAT OPTION ON, V9, P127, DOI 10.1007/s11864-008-0064-2
   Carlsson Christer, 2002, Acupunct Med, V20, P82
   Chaves J., 1993, HDB CLIN HYPNOSIS, P511, DOI DOI 10.1037/10274-023
   CHAVES JF, 1994, AM J CLIN HYPN, V37, P117, DOI 10.1080/00029157.1994.10403124
   Cho HK, 2016, LARYNGOSCOPE, V126, P608, DOI 10.1002/lary.25721
   Collins J, 1976, AANA J, V44, P62
   de Freitas GRM, 2014, PAIN MED, V15, P807, DOI 10.1111/pme.12332
   Dhalla IA, 2009, CAN MED ASSOC J, V181, P891, DOI 10.1503/cmaj.090784
   Dhond RP, 2008, PAIN, V136, P407, DOI 10.1016/j.pain.2008.01.011
   Dhond RP, 2007, PAIN, V128, P8, DOI 10.1016/j.pain.2007.01.001
   Dillworth T, 2012, TRANSL BEHAV MED, V2, P65, DOI 10.1007/s13142-011-0084-5
   Dumas EO, 2008, AAPS J, V10, P537, DOI 10.1208/s12248-008-9056-1
   Dunn KM, 2010, ANN INTERN MED, V152, P85, DOI 10.7326/0003-4819-152-2-201001190-00006
   Edenfield TM, 2012, PSYCHOL RES BEHAV MA, V5, P131, DOI 10.2147/PRBM.S34937
   Elvey R L, 1997, J Hand Ther, V10, P122
   Evans S, 2010, J PAIN SYMPTOM MANAG, V39, P904, DOI 10.1016/j.jpainsymman.2009.09.018
   Favara-Scacco C, 2001, MED PEDIATR ONCOL, V36, P474, DOI 10.1002/mpo.1112
   FRIEDMAN R, 1995, HEALTH PSYCHOL, V14, P509, DOI 10.1037/0278-6133.14.6.509
   Friedrichsdorf SJ, 2016, CHILDREN-BASEL, V3, DOI 10.3390/children3040042
   Friedrichsdorf Stefan J, 2013, J Opioid Manag, V9, P151, DOI 10.5055/jom.2013.0156
   Galantino Mary Lou, 2008, Pediatr Phys Ther, V20, P66, DOI 10.1097/PEP.0b013e31815f1208
   Gerik SM, 2005, SOUTH MED J, V98, P295, DOI 10.1097/01.SMJ.0000154772.49481.53
   Goldberg DS, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-770
   Golianu B, 2007, SEMIN PERINATOL, V31, P318, DOI 10.1053/j.semperi.2007.07.007
   Grant JA, 2011, PAIN, V152, P150, DOI 10.1016/j.pain.2010.10.006
   Grant JA, 2010, EMOTION, V10, P43, DOI 10.1037/a0018334
   Grant JA, 2009, PSYCHOSOM MED, V71, P106, DOI 10.1097/PSY.0b013e31818f52ee
   Groenewald CB, 2014, J PAIN, V15, P925, DOI 10.1016/j.jpain.2014.06.002
   Grossman P, 2004, J PSYCHOSOM RES, V57, P35, DOI 10.1016/S0022-3999(03)00573-7
   Han B, 2015, JAMA-J AM MED ASSOC, V314, P1468, DOI 10.1001/jama.2015.11859
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   Hashmi JA, 2013, BRAIN, V136, P2751, DOI 10.1093/brain/awt211
   Hassett AL, 2013, J PAIN, V14, P1390, DOI 10.1016/j.jpain.2013.06.010
   Hermesdorf M, 2016, J PAIN, V17, P606, DOI 10.1016/j.jpain.2016.01.474
   Hölzel BK, 2008, SOC COGN AFFECT NEUR, V3, P55, DOI 10.1093/scan/nsm038
   Hölzel BK, 2011, PERSPECT PSYCHOL SCI, V6, P537, DOI 10.1177/1745691611419671
   Hoffart C, 2014, ARTHRITIS RHEUMATOL, V66, pS201, DOI 10.1002/art.38581
   Hooker K.E., 2008, Gestalt Review, V12, P75, DOI DOI 10.5325/GESTALTREVIEW.12.1.0075
   Hsieh JC, 2001, NEUROSCI LETT, V307, P105, DOI 10.1016/S0304-3940(01)01952-8
   Hui KKS, 2010, AUTON NEUROSCI-BASIC, V157, P81, DOI 10.1016/j.autneu.2010.03.022
   Hui KKS, 2000, HUM BRAIN MAPP, V9, P13, DOI 10.1002/(SICI)1097-0193(2000)9:1<13::AID-HBM2>3.0.CO;2-F
   Jain G, 2014, PAIN PHYSICIAN, V17, P109
   Jindal V, 2008, J PEDIAT HEMATOL ONC, V30, P431, DOI 10.1097/MPH.0b013e318165b2cc
   Joyce A, 2010, ADV SCH MENT HEALTH, V3, P17, DOI 10.1080/1754730X.2010.9715677
   KABATZINN J, 1982, GEN HOSP PSYCHIAT, V4, P33, DOI 10.1016/0163-8343(82)90026-3
   KABATZINN J, 1985, J BEHAV MED, V8, P163, DOI 10.1007/BF00845519
   KABATZINN J, 1992, AM J PSYCHIAT, V149, P936
   Kelly KM, 2004, EUR J CANCER, V40, P2041, DOI 10.1016/j.ejca.2004.05.012
   Kemper KJ, 2000, PEDIATRICS, V105, P941
   King S, 2011, PAIN, V152, P2729, DOI 10.1016/j.pain.2011.07.016
   Kohen DP, 2014, CHILDREN-BASEL, V1, P74, DOI 10.3390/children1020074
   Kraag G, 2006, J SCHOOL PSYCHOL, V44, P449, DOI 10.1016/j.jsp.2006.07.001
   Kuehn BM, 2007, JAMA-J AM MED ASSOC, V297, P249, DOI 10.1001/jama.297.3.249
   Laengler A, 2008, EUR J CANCER, V44, P2233, DOI 10.1016/j.ejca.2008.07.020
   Lafferty WE, 2006, COMPLEMENT THER MED, V14, P100, DOI 10.1016/j.ctim.2006.01.009
   Lazar SW, 2005, NEUROREPORT, V16, P1893, DOI 10.1097/01.wnr.0000186598.66243.19
   Lee A. A., 2006, Journal of Chinese Medicine, P21
   Lee MS, 2011, CHIN J INTEGR MED, V17, P187, DOI 10.1007/s11655-011-0665-7
   Lin JG, 2002, PAIN, V99, P509, DOI 10.1016/S0304-3959(02)00261-0
   Lu DP, 2013, MED ACUPUNCT, V25, P311, DOI 10.1089/acu.2012.0921
   Ludwig DS, 2008, JAMA-J AM MED ASSOC, V300, P1350, DOI 10.1001/jama.300.11.1350
   Lund I, 2016, J PAIN RES, V9, P157, DOI 10.2147/JPR.S55580
   Lundeberg T, 2002, INT CONGR SER, V1238, P3, DOI 10.1016/S0531-5131(02)00416-8
   Manchikanti Kavita N, 2008, J Opioid Manag, V4, P271, DOI 10.5055/jom.2008.0031
   Manheimer E, 2005, ANN INTERN MED, V142, P651, DOI 10.7326/0003-4819-142-8-200504190-00014
   Mano KEJ, 2013, ALTERN THER HEALTH M, V19, P8
   Mathews L, 2011, INDIAN J PALLIAT CAR, V17, P70, DOI 10.4103/0973-1075.76247
   McCracken LM, 2007, PAIN, V131, P63, DOI 10.1016/j.pain.2006.12.013
   McGeown WJ, 2015, PSYCHIAT RES-NEUROIM, V231, P151, DOI 10.1016/j.pscychresns.2014.11.015
   McLellan AT, 2008, JAMA-J AM MED ASSOC, V300, P2672, DOI 10.1001/jama.2008.793
   MELZACK R, 1977, PAIN, V3, P3, DOI 10.1016/0304-3959(77)90032-X
   MILLER JJ, 1995, GEN HOSP PSYCHIAT, V17, P192, DOI 10.1016/0163-8343(95)00025-M
   Molassiotis Alexander, 2004, Eur J Oncol Nurs, V8, P50, DOI 10.1016/S1462-3889(03)00054-1
   Montgomery GH, 2000, INT J CLIN EXP HYP, V48, P138, DOI 10.1080/00207140008410045
   Morgan D, 2003, PSYCHOTHER RES, V13, P123, DOI [10.1080/713869628, 10.1093/ptr/kpg004]
   Morone NE, 2008, PAIN, V134, P310, DOI 10.1016/j.pain.2007.04.038
   Nahin RL, 2016, MAYO CLIN PROC, V91, P1292, DOI 10.1016/j.mayocp.2016.06.007
   Napadow V, 2007, PAIN, V130, P254, DOI 10.1016/j.pain.2006.12.003
   Niemtzow RC, 2015, MED ACUPUNCT, V27, P344, DOI 10.1089/acu.2014.1055
   Niemtzow RC, 2007, MED ACUPUNCT, V19, P225, DOI 10.1089/acu.2007.0603
   Ochi JW, 2013, INT J PEDIATR OTORHI, V77, P2058, DOI 10.1016/j.ijporl.2013.10.008
   Okie S, 2010, NEW ENGL J MED, V363, P1981, DOI 10.1056/NEJMp1011512
   Post-White Janice, 2005, Semin Oncol Nurs, V21, P107
   Rainville P, 1999, J COGNITIVE NEUROSCI, V11, P110, DOI 10.1162/089892999563175
   Rainville P, 2002, J COGNITIVE NEUROSCI, V14, P887, DOI 10.1162/089892902760191117
   Robbins C.J., 2002, COGN BEHAV PRACT, V9, P50, DOI [10.1016/S1077-7229(02)80040-2, 10.1016/s1077-7229, DOI 10.1016/S1077-7229, DOI 10.1016/S1077-7229(02)80040-2]
   Rogovik AL, 2007, CAN FAM PHYSICIAN, V53, P823
   Rosenzweig S, 2010, J PSYCHOSOM RES, V68, P29, DOI 10.1016/j.jpsychores.2009.03.010
   Sibinga EMS, 2013, PREV MED, V57, P799, DOI 10.1016/j.ypmed.2013.08.027
   Simons LE, 2015, PAIN, V156, P1511, DOI 10.1097/j.pain.0000000000000199
   Slover Robin, 2010, Adv Pediatr, V57, P141, DOI 10.1016/j.yapd.2010.08.009
   Sobel DS, 2000, PROG BRAIN RES, V122, P393
   Sobel DS, 2000, JAMA-J AM MED ASSOC, V284, P1705, DOI 10.1001/jama.284.13.1705
   Stevens BJ, 2011, CAN MED ASSOC J, V183, pE403, DOI 10.1503/cmaj.101341
   Taylor EM, 2008, PAIN RES MANAG, V13, P25, DOI 10.1155/2008/478102
   Terhune DB, 2015, NEUROPHYSIOL CLIN, V45, P177, DOI 10.1016/j.neucli.2014.10.003
   TERRIET G, 1990, J CLIN EPIDEMIOL, V43, P1191, DOI 10.1016/0895-4356(90)90020-P
   Thera N., 1962, HEART BUDDHIST MEDIT
   THOMAS M, 1991, AM J CHINESE MED, V19, P95, DOI 10.1142/S0192415X91000156
   Tsai SL, 2016, MED ACUPUNCT, V28, P293, DOI 10.1089/acu.2016.29027.slt.correx
   Tsai SL, 2016, ANN EMERG MED, V68, P583, DOI 10.1016/j.annemergmed.2016.05.006
   Vallath N, 2010, INDIAN J PALLIAT CAR, V16, P1, DOI 10.4103/0973-1075.63127
   Vickers AJ, 2014, JAMA-J AM MED ASSOC, V311, P955, DOI 10.1001/jama.2013.285478
   Volkow ND, 2011, JAMA-J AM MED ASSOC, V305, P1299, DOI 10.1001/jama.2011.401
   Wang BG, 1997, ANESTH ANALG, V85, P406, DOI 10.1097/00000539-199708000-00029
   Woolery A, 2004, ALTERN THER HEALTH M, V10, P60
   Woolf CJ, 2010, J CLIN INVEST, V120, P3742, DOI 10.1172/JCI45178
   Wu MT, 1999, RADIOLOGY, V212, P133, DOI 10.1148/radiology.212.1.r99jl04133
   Wu MT, 2002, NEUROIMAGE, V16, P1028, DOI 10.1006/nimg.2002.1145
   Yaster M, 1996, PEDIATRICS, V98, P135
   Zeidan F, 2012, NEUROSCI LETT, V520, P165, DOI 10.1016/j.neulet.2012.03.082
   Zeidan F, 2010, J PAIN, V11, P199, DOI 10.1016/j.jpain.2009.07.015
   ZELTZER L, 1982, J PEDIATR-US, V101, P1032
   Zeltzer LK, 2002, J PAIN SYMPTOM MANAG, V24, P437, DOI 10.1016/S0885-3924(02)00506-7
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zheng Z, 2008, EUR J PAIN, V12, P671, DOI 10.1016/j.ejpain.2007.10.003
NR 136
TC 34
Z9 41
U1 1
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD JUN
PY 2017
VL 4
IS 6
AR 50
DI 10.3390/children4060050
PG 13
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA EZ0TW
UT WOS:000404419400008
PM 28632194
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tuck, CM
AF Tuck, Claire M.
TI A 54-year-old woman with degenerative back pain
SO ACUPUNCTURE IN MEDICINE
LA English
DT Editorial Material
ID ACUPUNCTURE
AB Back pain is a common symptom: up to 70% of UK adults experience this symptom by the age of 60 and most have moderate to severe pain. Back pain accounted for 12% of consultations to traditional acupuncturists in 2001 and is one of the most common reasons for consultation with an acupuncturist. This case report concerns a 54-year-old woman with metastatic breast cancer and degenerative lower back pain, which remained painful despite intensive pharmaceutical management and facet joint injection and was ultimately successfully managed with two 30 min acupuncture treatments 2 weeks apart, using eight points on the BL meridians. Acupuncture treatment using tender points was later trialled for neuropathic pain secondary to local recurrence in her mastectomy scar, however this was unsuccessful and inpatient hospice admission for further intensive pharmaceutical management was required.
C1 Strathcarron Hosp, Denny FK6 5HJ, Stirlingshire, England.
RP Tuck, CM (corresponding author), Strathcarron Hosp, Randolph Hill, Denny FK6 5HJ, Stirlingshire, England.
EM clairetuck@nhs.net
CR AUNG S, 1994, ACUPUNCT MED, V12, P37
   DESTOUTZ ND, 1995, J PAIN SYMPTOM MANAG, V10, P378, DOI 10.1016/0885-3924(95)90924-C
   *END PHARM, 2009, LID 5 PATCH PRESCR I
   Freynhagen R, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b3002
   Furlan AD, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001351.pub2
   Hempenstall K, 2005, PLOS MED, V2, P628, DOI 10.1371/journal.pmed.0020164
   Kotani N, 2001, REGION ANESTH PAIN M, V26, P532, DOI 10.1053/rapm.2001.25897
   Lee H, 2005, EUR J PAIN, V9, P437, DOI 10.1016/j.ejpain.2004.10.004
   Manheimer E, 2005, ANN INTERN MED, V142, P651, DOI 10.7326/0003-4819-142-8-200504190-00014
   *NHS CLIN KNWOL SU, 2009, BAK PAIN LOW RAD
   Prady Stephanie L, 2007, Acupunct Med, V25, P121
   *PRIC INC, DEUR
   Redfearn T., 1992, ACUPUNCT MED, V10, P73
   *SIGN, 2008, CONTR CANC PAIN SIGN
   Spiller Juliet, 2007, Acupunct Med, V25, P109
   *UK STAT AUTH, AD EXP BACK PAIN AG
   Yuan J, 2008, COMPLEMENT THER MED, V16, P295, DOI 10.1016/j.ctim.2008.04.006
   BACK PAIN BANDOLIER
NR 18
TC 3
Z9 5
U1 0
U2 5
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-5284
J9 ACUPUNCT MED
JI Acupunct. Med.
PD MAR
PY 2010
VL 28
IS 1
BP 46
EP 48
DI 10.1136/aim.2009.000687
PG 3
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 665DH
UT WOS:000283014900011
PM 20351378
DA 2026-01-16
ER

PT J
AU Bontoux, D
   Couturier, D
   Menkès, CJ
AF Bontoux, Daniel
   Couturier, Daniel
   Menkes, Charles-Joel
TI Place of alternative therapies in medical practice (acupuncture,
   hypnosis, osteopathy, tai-chi, etc.)
SO BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
LA French
DT Article
DE COMPLEMENTARY THERAPIES; ACUPUNCTURE; HYPNOSIS; MANIPULATION,
   OSTEOPATHIC; TAI JI; QIGONG; PLACEBO EFFECT
ID LOW-BACK-PAIN; RANDOMIZED CONTROLLED-TRIAL; TENSION-TYPE HEADACHE;
   SPINAL MANIPULATION; CANCER-CHEMOTHERAPY; MANUAL THERAPIES;
   OLDER-ADULTS; OSTEOARTHRITIS; FIBROMYALGIA; KNEE
AB Do so-called alternative therapies have a place in the public hospital? The authors were prompted to examine this question following the appearance of these approaches in several public medical centers.
   Reviews and meta-analyses of controlled clinical trials show that acupuncture, manual osteopathic medicine and hypnosis (the alternative therapies most commonly used in Paris hospitals) are helpful in only a few situation, such as lower back pain, cervical pain, some headaches (acupuncture and spinal manipulations), nausea and vomiting due to cancer chemotherapy (acupuncture and hypnosis), and prevention of care-related pain in children (hypnosis). Tai-chi also appears to help prevent falls and to improve balance in elderly persons. However, these methods have few or no advantages over classical treatments or even placebo procedures.
   Despite these limitations, alternative therapies are widely appreciated by the public, and most French medical schools offer optional study modules. Public hospitals, particularly teaching hospitals and cancer care centers, cannot be criticized for allowing these practices a place in their care supply. The authors make several recommendations intended to ensure that hospitals which agree to these therapies are not considered to be endorsing them, but rather to be guaranteeing their proper use and their scientific evaluation in terms of patient benefit. These therapies are subsidiary to conventional treatments and cannot replace them.
CR Albuquerque FC, 2011, J NEUROSURG, V115, P1197, DOI 10.3171/2011.8.JNS111212
   [Anonymous], COCHRANE DATA S 0120
   [Anonymous], ANATOMY
   [Anonymous], CHIROPRACTIC VS MED
   [Anonymous], COCHRANE DATA S 0512
   [Anonymous], COCHRANE DATA S 0708
   [Anonymous], ARCH PEDIAT S1
   [Anonymous], COCHRANE DATA S 0317
   [Anonymous], COCHRANE DATA S 1008
   [Anonymous], THESIS U MARC BLOCH
   [Anonymous], webpages that reported the news of the discovery and the debate that followed are still accessibile
   [Anonymous], COCHRANE DATA S 0601
   [Anonymous], REV RHUM, DOI DOI 10.1016/S1169-8330(02)00019-4
   [Anonymous], CONT HYPN
   [Anonymous], JAMA
   [Anonymous], TECHNIC PRACTICE CHI
   [Anonymous], J CLIN ONCOL
   [Anonymous], SCI CHIROPRACTIC
   [Anonymous], ACTUALITE RHUMATOLOG
   Assendelft WJ, 2004, COCHRANE DB SYST REV, V1, DOI DOI 10.1002/14651858.CD000447.PUB2
   Auquier L, 2006, B ACAD NAT MED PARIS, V190, P221, DOI 10.1016/S0001-4079(19)33365-5
   Benedetti F, 2006, PAIN, V121, P133, DOI 10.1016/j.pain.2005.12.016
   Blakemore SJ, 2003, CURR OPIN NEUROBIOL, V13, P219, DOI 10.1016/S0959-4388(03)00043-6
   Brien S, 2011, RHEUMATOLOGY, V50, P1070, DOI 10.1093/rheumatology/keq234
   Brinkhaus B, 2006, ARCH INTERN MED, V166, P450
   Bronfort G, 2012, ANN INTERN MED, V156, P1, DOI 10.7326/0003-4819-156-1-201201030-00002
   Bronfort Gert, 2010, Chiropr Osteopat, V18, P3, DOI 10.1186/1746-1340-18-3
   Chen SC, 2010, J ALTERN COMPLEM MED, V16, P1153, DOI 10.1089/acm.2009.0560
   Cherkin DC, 2009, ARCH INTERN MED, V169, P858, DOI 10.1001/archinternmed.2009.65
   Dagenais S, 2010, SPINE J, V10, P918, DOI 10.1016/j.spinee.2010.07.389
   Ernst E, 2009, RESP MED, V103, P1791, DOI 10.1016/j.rmed.2009.06.017
   Ernst E, 2009, INT J CLIN PRACT, V63, P1351, DOI 10.1111/j.1742-1241.2009.02133.x
   Fernández-de-las-Peñas C, 2006, CLIN J PAIN, V22, P278, DOI 10.1097/01.ajp.0000173017.64741.86
   Finniss DG, 2010, LANCET, V375, P686, DOI 10.1016/S0140-6736(09)61706-2
   Fu LM, 2009, J ALTERN COMPLEM MED, V15, P133, DOI 10.1089/acm.2008.0135
   Gillespie Lesley D, 2012, Cochrane Database Syst Rev, pCD007146, DOI [10.1002/14651858.CD007146.pub2, 10.1002/14651858.CD007146.pub3]
   Guo X, 2008, J ALTERN COMPLEM MED, V14, P27, DOI 10.1089/acm.2007.7213
   Haake M, 2007, ARCH INTERN MED, V167, P1892, DOI 10.1001/archinte.167.17.1892
   Hall AM, 2011, ARTHRIT CARE RES, V63, P1576, DOI 10.1002/acr.20594
   Hróbjartsson A, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003974.pub3
   Hurwitz EL, 2008, SPINE, V33, pS123, DOI 10.1097/BRS.0b013e3181644b1d
   Irwin MR, 2008, SLEEP, V31, P1001
   Jäkel A, 2011, J AM OSTEOPATH ASSOC, V111, P685
   Kaminskyj Adrienne, 2010, J Can Chiropr Assoc, V54, P24
   Kaptchuk TJ, 2008, BMJ-BRIT MED J, V336, P999, DOI 10.1136/bmj.39524.439618.25
   Langhorst J, 2010, RHEUMATOLOGY, V49, P778, DOI 10.1093/rheumatology/kep439
   Lee MS, 2007, J HYPERTENS, V25, P1525, DOI 10.1097/HJH.0b013e328092ee18
   Lee MS, 2010, J EVAL CLIN PRACT, V16, P818, DOI 10.1111/j.1365-2753.2009.01210.x
   Lee MS, 2009, COMPLEMENT THER MED, V17, P236, DOI 10.1016/j.ctim.2009.05.001
   Licciardone JC, 2003, SPINE, V28, P1355, DOI 10.1097/00007632-200307010-00002
   Linde K, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001218.pub2
   Liossi C, 2009, PAIN, V142, P255, DOI 10.1016/j.pain.2009.01.017
   Liu CZ, 2011, PAIN MED, V12, P300, DOI 10.1111/j.1526-4637.2010.01017.x
   Lystad RP, 2011, CHIROPR MAN THER, V19, DOI 10.1186/2045-709X-19-21
   Manheimer E, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001977.pub2
   Maquet P, 1999, BIOL PSYCHIAT, V45, P327, DOI 10.1016/S0006-3223(97)00546-5
   Martin DP, 2006, MAYO CLIN PROC, V81, P749, DOI 10.4065/81.6.749
   Martin-Sanchez Eva, 2009, Open Rheumatol J, V3, P25, DOI 10.2174/1874312900903010025
   Mawdsley JE, 2008, AM J GASTROENTEROL, V103, P1460, DOI 10.1111/j.1572-0241.2008.01845.x
   Mayhew E, 2007, RHEUMATOLOGY, V46, P801, DOI 10.1093/rheumatology/kel406
   Melchart D, 2005, BMJ-BRIT MED J, V331, P376, DOI 10.1136/bmj.38512.405440.8F
   Molassiotis A, 2005, ANN ONCOL, V16, P655, DOI 10.1093/annonc/mdi110
   Molsberger AF, 2010, PAIN, V151, P146, DOI 10.1016/j.pain.2010.06.036
   Posadzki P, 2011, CEPHALALGIA, V31, P964, DOI 10.1177/0333102411405226
   Posadzki P, 2011, HEADACHE, V51, P1132, DOI 10.1111/j.1526-4610.2011.01932.x
   Proctor ML, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002119.pub3
   Rand D, 2011, AGE AGEING, V40, P297, DOI 10.1093/ageing/afr037
   Reid SA, 2005, MANUAL THER, V10, P4, DOI 10.1016/j.math.2004.03.006
   Reid SA, 2008, MANUAL THER, V13, P357, DOI 10.1016/j.math.2007.03.006
   Richardson J, 2007, EUR J CANCER CARE, V16, P402, DOI 10.1111/j.1365-2354.2006.00736.x
   Rodine Robert J, 2012, J Can Chiropr Assoc, V56, P18
   Rubinstein SM, 2011, SPINE, V36, pE825, DOI 10.1097/BRS.0b013e3182197fe1
   Sirigu A, 2004, NAT NEUROSCI, V7, P80, DOI 10.1038/nn1160
   Smith CA, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009232
   Smith CA, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007854.pub2
   Standaert CJ, 2011, SPINE, V36, pS120, DOI 10.1097/BRS.0b013e31822ef878
   Still A., 1902, PHILOS MECH PRINCIPL
   Suarez-Almazor ME, 2010, ARTHRIT CARE RES, V62, P1229, DOI 10.1002/acr.20225
   Thieme Kati, 2009, Curr Rheumatol Rep, V11, P443
   Trinh KV, 2004, RHEUMATOLOGY, V43, P1085, DOI 10.1093/rheumatology/keh247
   Vas J, 2012, PAIN, V153, P1883, DOI 10.1016/j.pain.2012.05.033
   Walker BF, 2011, SPINE, V36, P230, DOI 10.1097/BRS.0b013e318202ac73
   Wang CC, 2010, NEW ENGL J MED, V363, P743, DOI 10.1056/NEJMoa0912611
   Wang CC, 2009, ARTHRIT RHEUM-ARTHR, V61, P1545, DOI 10.1002/art.24832
   Witt C, 2005, LANCET, V366, P136, DOI 10.1016/S0140-6736(05)66871-7
   Yeh CH, 2012, J ALTERN COMPLEM MED, V18, P334, DOI 10.1089/acm.2011.0102
   Yeh Gloria Y, 2008, Prev Cardiol, V11, P82
   Yeh GY, 2011, ARCH INTERN MED, V171, P750, DOI 10.1001/archinternmed.2011.150
   Yuan J, 2008, SPINE, V33, pE887, DOI 10.1097/BRS.0b013e318186b276
NR 89
TC 4
Z9 9
U1 3
U2 33
PU ELSEVIER MASSON SAS EDITEUR
PI ISSY LES  MOULINEAUX CEDEX
PA 62, RUE CAMILLE DESMOULINS, ISSY LES  MOULINEAUX CEDEX, 92442, FRANCE
SN 0001-4079
EI 2271-4820
J9 B ACAD NAT MED PARIS
JI Bull. Acad. Natl. Med.
PD MAR
PY 2013
VL 197
IS 3
BP 717
EP 757
DI 10.1016/S0001-4079(19)31565-1
PG 41
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AL8UH
UT WOS:000339414700019
DA 2026-01-16
ER

PT J
AU Berliere, M
   Piette, N
   Bernard, M
   Lacroix, C
   Gerday, A
   Samartzi, V
   Coyette, M
   Roelants, F
   Docquier, MA
   Touil, N
   Watremez, C
   Piette, P
   Duhoux, FP
AF Berliere, Martine
   Piette, Nathan
   Bernard, Marion
   Lacroix, Camille
   Gerday, Amandine
   Samartzi, Vasiliki
   Coyette, Maude
   Roelants, Fabienne
   Docquier, Marie-Agnes
   Touil, Nassim
   Watremez, Christine
   Piette, Philippe
   Duhoux, Francois P.
TI Hypnosis Sedation Reduces the Duration of Different Side Effects of
   Cancer Treatments in Breast Cancer Patients Receiving Neoadjuvant
   Chemotherapy
SO CANCERS
LA English
DT Article
DE polyneuropathy; postoperative pain; musculoskeletal pain; cancer-related
   fatigue; neoadjuvant chemotherapy; hypnosis sedation
ID INDUCED PERIPHERAL NEUROPATHY; QUALITY-OF-LIFE; PERSISTENT PAIN;
   RISK-FACTORS; FATIGUE; INFLAMMATION; PREVALENCE; SURGERY; ACUPUNCTURE;
   PREDICTORS
AB Simple Summary Reducing side effects of cancer treatments is a major challenge for clinicians involved in the management of breast cancer patients. Among patients receiving neoadjuvant chemotherapy followed by surgery, radiotherapy and endocrine therapy, prolonged side effects frequently mentioned are: polyneuropathy, musculoskeletal pain, postoperative pain and cancer-related fatigue. Conventional drugs have proven to be ineffective in treating theses effects, except for postoperative pain. This is the reason why we prospectively tested the impact of hypnosis sedation used as anesthetic technique for breast cancer surgery on the different side effects of cancer treatment. Despite the limitations of this small non-randomized cohort, preliminary results are very encouraging. Background: Reducing side effects of cancer treatments is a major challenge for clinicians involved in the management of breast cancer patients. Methods: We analyzed data from 63 patients (32 in the general anesthesia group and 31 in the hypnosis sedation group) who were included in 1 prospective non-randomized trial evaluating hypnosis sedation in breast cancer treatment. The patients were followed every 3 months for 2 years. All patients received neoadjuvant chemotherapy with 4 cycles of epirubicin and cyclophosphamide followed by taxanes. Thereafter, patients underwent surgery while on general anesthesia or while on hypnosis sedation. Radiotherapy was administered according to institutional guidelines. Endocrine therapy was prescribed if tumors expressed hormone receptors. Prevalence, intensity and duration of polyneuropathy, musculoskeletal pain, postoperative pain and cancer-related fatigue were assessed at each medical visit. Results: Symptoms duration was statistically reduced for polyneuropathy (p < 0.05), musculoskeletal pain (p < 0.05) postoperative pain and cancer-related fatigue (p < 0.05) in the hypnosis group. Conclusion: Despite the limitations of this study (lack of randomization and small size) we conclude that hypnosis sedation may exert a role on different side effects of breast cancer treatment in patients receiving neoadjuvant chemotherapy, mainly by reducing their duration.
C1 [Berliere, Martine; Bernard, Marion; Lacroix, Camille; Gerday, Amandine; Coyette, Maude; Duhoux, Francois P.] Clin Univ St Luc, King Albert II Canc Inst, Breast Clin, B-1200 Woluwe St Lambert, Belgium.
   [Piette, Nathan] Clin St Pierre, Dept Oncol, B-1340 Ottignies, Belgium.
   [Samartzi, Vasiliki] Hop Jolimont, Dept Gynaecol, B-7100 La Louviere, Belgium.
   [Roelants, Fabienne; Docquier, Marie-Agnes; Touil, Nassim; Watremez, Christine] Catholic Univ Louvain, Clin Univ St Luc, Dept Anesthesiol, B-1340 Ottignies, Belgium.
   [Piette, Philippe] Grand Hop Charleroi, Med & Financial Dept, B-6000 Charleroi, Belgium.
C3 Universite Catholique Louvain; Cliniques Universitaires Saint-Luc;
   Groupe Jolimont; Universite Catholique Louvain; Grand Hopital De
   Charleroi
RP Berliere, M (corresponding author), Clin Univ St Luc, King Albert II Canc Inst, Breast Clin, B-1200 Woluwe St Lambert, Belgium.
EM martine.berliere@uclouvain.be; nathan.piette@student.uclouvain.be;
   marion.bernard@student.uclouvain.be;
   camille.lacroix@student.uclouvain.be; amandine.gerday@uclouvain.be;
   vassiliki.samartzi@jolimont.be; maude.coyette@uclouvain.be;
   fabienne.roelants@uclouvain.be; marie-agnes.docquier@uclouvain.be;
   nassim.touil@uclouvain.be; christine.watremez@uclouvain.be;
   Philippe.piette@ghdc.be; francois.duhoux@uclouvain.be
RI Duhoux, Francois/A-4728-2012
FU  [2017-034]
FX The authors disclosed receipt of the following financial support for the
   research, authorship and/or publication of this article: the second
   study-related in this article-was performed with a grant of the
   Fondation Roi Baudouin received in 2016 by our team. Francois P. Duhoux
   received a postdoctoral clinical mandate (2017-034) from the
   not-for-profit organization 'Foundation Against Cancer' (Brussels,
   Belgium).
CR Andersen KG, 2011, J PAIN, V12, P725, DOI 10.1016/j.jpain.2010.12.005
   [Anonymous], 2013, R: A language and environment for statistical computing, DOI DOI 10.3389/FMED.2020.558696
   Balkwill F, 2001, LANCET, V357, P539, DOI 10.1016/S0140-6736(00)04046-0
   Balkwill FR, 2012, SEMIN CANCER BIOL, V22, P33, DOI 10.1016/j.semcancer.2011.12.005
   Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Berger AM, 2015, J NATL COMPR CANC NE, V13, P1012, DOI 10.6004/jnccn.2015.0122
   Berger AM, 2015, CA-CANCER J CLIN, V65, P190, DOI 10.3322/caac.21268
   Berlière M, 2018, BREAST, V37, P114, DOI 10.1016/j.breast.2017.10.017
   Berliere M., 2019, MECH INVOLVED HYPNOS, V79
   Bower JE, 2007, BRAIN BEHAV IMMUN, V21, P863, DOI 10.1016/j.bbi.2007.03.013
   Ciruelos E, 2019, ONCOLOGIST, V24, pE1024, DOI 10.1634/theoncologist.2017-0664
   Cramer H, 2015, INTEGR CANCER THER, V14, P5, DOI 10.1177/1534735414550035
   Crusz SM, 2015, NAT REV CLIN ONCOL, V12, P584, DOI 10.1038/nrclinonc.2015.105
   Defechereux T, 2000, ANN CHIR, V125, P539, DOI 10.1016/S0003-3944(00)00238-8
   Diakos CI, 2014, LANCET ONCOL, V15, pE493, DOI 10.1016/S1470-2045(14)70263-3
   Donovan KA, 2013, PSYCHO-ONCOLOGY, V22, P737, DOI 10.1002/pon.3085
   Eckhoff L, 2015, EUR J CANCER, V51, P292, DOI 10.1016/j.ejca.2014.11.024
   Fabi A, 2020, ANN ONCOL, V31, P713, DOI 10.1016/j.annonc.2020.02.016
   Faller H, 2013, J CLIN ONCOL, V31, P782, DOI 10.1200/JCO.2011.40.8922
   Forget P, 2020, J CLIN MED, V9, DOI 10.3390/jcm9123831
   Gärtner R, 2009, JAMA-J AM MED ASSOC, V302, P1985, DOI 10.1001/jama.2009.1568
   Gewandter JS, 2020, SUPPORT CARE CANCER, V28, P2553, DOI 10.1007/s00520-019-05063-x
   Goedendorp MM, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006953.pub2
   Gorin SS, 2012, J CLIN ONCOL, V30, P539, DOI 10.1200/JCO.2011.37.0437
   Grégoire C, 2018, BMC CANCER, V18, DOI 10.1186/s12885-018-4607-z
   Guarino A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9010209
   Hammond DC, 2010, EXPERT REV NEUROTHER, V10, P263, DOI 10.1586/ERN.09.140
   Hamood R, 2018, BREAST CANCER RES TR, V167, P157, DOI 10.1007/s10549-017-4485-0
   Hurtz HJ, 2017, BREAST CANCER RES TR, V165, P721, DOI 10.1007/s10549-017-4365-7
   Ilhan E, 2017, PAIN, V158, P2082, DOI 10.1097/j.pain.0000000000001004
   Jensen MP, 2010, PAIN MED, V11, P1099, DOI 10.1111/j.1526-4637.2010.00880.x
   Jensen MP, 2005, INT J CLIN EXP HYP, V53, P198, DOI 10.1080/00207140590927545
   Johannsen M, 2013, BREAST CANCER RES TR, V138, P675, DOI 10.1007/s10549-013-2503-4
   Jordan B, 2019, BREAST CARE, V14, P79, DOI 10.1159/000499599
   Kehlet H, 2006, LANCET, V367, P1618, DOI 10.1016/S0140-6736(06)68700-X
   Lacroix C, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419869494
   Laird BJ, 2013, ONCOLOGIST, V18, P1050, DOI 10.1634/theoncologist.2013-0120
   Lancaster RB, 2016, CURR SURG REP, V4, DOI 10.1007/s40137-016-0133-6
   Liampas A, 2021, PAIN THER, V10, P55, DOI 10.1007/s40122-020-00210-3
   Malik UR, 2001, CANCER, V92, P1664, DOI 10.1002/1097-0142(20010915)92:6+<1664::AID-CNCR1494>3.0.CO;2-9
   Meretoja TJ, 2017, J CLIN ONCOL, V35, P1660, DOI 10.1200/JCO.2016.70.3413
   Molassiotis A, 2013, ANN ONCOL, V24, P1645, DOI 10.1093/annonc/mdt034
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Montgomery GH, 2002, INT J CLIN EXP HYP, V50, P17, DOI 10.1080/00207140208410088
   Montgomery GH, 2002, ANESTH ANALG, V94, P1639, DOI 10.1097/00000539-200206000-00052
   Montgomery GH, 2007, JNCI-J NATL CANCER I, V99, P1304, DOI 10.1093/jnci/djm106
   Montgomery GH, 2009, HEALTH PSYCHOL, V28, P317, DOI 10.1037/a0013582
   Munn LL, 2017, WIRES SYST BIOL MED, V9, DOI 10.1002/wsbm.1370
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Fabro EAN, 2012, BREAST, V21, P321, DOI 10.1016/j.breast.2012.01.019
   Park SB, 2013, CA-CANCER J CLIN, V63, P419, DOI 10.3322/caac.21204
   Postma TJ, 2005, EUR J CANCER, V41, P1135, DOI 10.1016/j.ejca.2005.02.012
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Staff NP, 2017, ANN NEUROL, V81, P772, DOI 10.1002/ana.24951
   Swain Sandra M, 2008, Clin Adv Hematol Oncol, V6, P455
   Syrjala KL, 2014, J CLIN ONCOL, V32, P1703, DOI 10.1200/JCO.2013.54.4825
   Wang L, 2016, CAN MED ASSOC J, V188, pE352, DOI 10.1503/cmaj.151276
NR 57
TC 11
Z9 12
U1 0
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD AUG
PY 2021
VL 13
IS 16
AR 4147
DI 10.3390/cancers13164147
PG 14
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA UF8ZE
UT WOS:000688855600001
PM 34439301
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Omura, Y
   Lu, D
   Duvvi, H
   Yopor, D
   Nihrane, A
   Corro, P
   Corro, C
   Shimotsuura, Y
   Ohki, M
AF Omura, Yoshiaki
   Lu, Dominic
   Duvvi, Harsha
   Yopor, Dario
   Nihrane, Abdallah
   Corro, Prudencio
   Corro, Carol
   Shimotsuura, Yashihiro
   Ohki, Motomu
TI "CLINICAL DIAMOND" SECTION of Acupuncture & Electro-Therapeutics
   Research, International Journal of Integrated Medicine - Clinically
   Very Useful & Important Information in Diagnosis &/or Treatment of
   Patients
SO ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH
LA English
DT Article
DE Non-Invasive Early Diagnostic Method; Lung Cancer; Colon Cancer;
   Integral alpha 5 beta 1; 8-OH-dG; DNA Mutations; Optimal Dose of Vitamin
   D3 & White Fleshed Dragon Fruit; Selective Drug Uptake Enhancement
   Method; Thymus Gland Representation Area; Thymosin alpha 1; Thymosin
   beta 4
ID CANCER
AB Our study indicated that cancer can develop in very short time if there is a strong coexisting infection of HPV-16 and HHV-8 in the presence of strong repeated electromagnetic field. Recently the first author himself developed cancer by drinking eggnog, which happened to contain strongest infection of both these 2 viruses, in the presence of Electro-magnetic field. Sometimes these cancers can also appear as a small metastatic mass in the back of the finger or hand. These metastatic tumors that are appearing in the hand are often misdiagnosed as benign lipoma since they do not seem to create any pain or other symptoms. In this article we described 2 examples of such an unusual metastatic tumor appearing as if it is a benign lipoma. If left untreated, or biopsy or surgical removal of these metastatic tumors can be new sources of metastases or unrecognized existence of an advanced tumor of original organ without significant symptoms. These rapidly developed cancers are infectious & difficult to treat. Fortunately, we succeeded in discovering an essential parameter required to completely inhibit these cancers by implementing the combination of the following 3 different methods given sequentially 1) Simultaneous Intake of Optimal Doses of Vitamin D3 (with 10 unique beneficial effects) every 8 hours & white fleshed Dragon fruit (since we found it containing close to optimal dose of DHEA, Zinc. Magnesium, Lithium, and a small amount of Vitamin D3 etc.) every 24 hours; 2) Selective Drug Uptake Enhancement Method; 3) Manual Stimulation of the Thymus Gland Representation Area of the Back of Each Hand. When these 3 different methods are used consequently there is a possibility of safe effective treatment for hopelessly advanced cancer patients, if Thymosin alpha 1 & Thymosin beta 4 are both very significantly increased to 800ng or higher.
C1 [Omura, Yoshiaki] New York Med Coll, Dept Family & Community Med, Valhalla, NY 10595 USA.
   [Omura, Yoshiaki] Int Coll Acupuncture & Electrotherapeut ICAET, New York, NY USA.
   [Omura, Yoshiaki] Heart Dis Res Fdn, Med Res, New York, NY USA.
   [Lu, Dominic; Yopor, Dario] Univ Penn, Oral Med, Philadelphia, PA 19104 USA.
   [Lu, Dominic; Yopor, Dario] Amer Soc Adv Anesthesia Dent, Bound Brook, NJ USA.
   [Lu, Dominic; Yopor, Dario] ICAET, Integrat Dent, New York, NY USA.
   [Duvvi, Harsha] New York Med Coll, Dept Family & Prevent Med, Valhalla, NY 10595 USA.
   [Duvvi, Harsha; Nihrane, Abdallah; Corro, Prudencio; Corro, Carol; Shimotsuura, Yashihiro] ICAET, Integrat Med, New York, NY USA.
   [Nihrane, Abdallah] Mt Sinai Sch Med, Dept Med, New York, NY USA.
   [Nihrane, Abdallah] NAIAD, NIH, Bethesda, MD USA.
   [Corro, Prudencio; Corro, Carol] ICAET, Integrat Nursing, New York, NY USA.
   [Shimotsuura, Yashihiro] Japan Bi Digital O Ring Test Assoc, Tokyo, Japan.
   [Shimotsuura, Yashihiro; Ohki, Motomu] ORT Life Sci Res Inst, Kurume, Fukuoka, Japan.
C3 New York Medical College; University of Pennsylvania; New York Medical
   College; Icahn School of Medicine at Mount Sinai; National Institutes of
   Health (NIH) - USA; NIH National Institute of Allergy & Infectious
   Diseases (NIAID)
RP Omura, Y (corresponding author), 800 Riverside Dr,8-I, New York, NY 10032 USA.
EM icaet@vahoo.com
RI Ohki, Motomu/KBB-3579-2024
OI Ohki, Motomu/0000-0002-3879-4059
CR [Anonymous], WHAT IS LIFE NEXT 10
   OMURA Y, 1994, ACUPUNCTURE ELECTRO, V19, P39, DOI 10.3727/036012994816357394
   Omura Y, 1995, ACUPUNCTURE ELECTRO, V20, P195, DOI 10.3727/036012995816357014
   Omura Y., 2000, ACUPUNCTURE ELECTRO, V25, P211
   Omura Y., 2008, ACUPUNCTURE ELECTRO, V33, P233
   Omura Y., U. S. Patent, Patent No. [5,188,107, 5188107]
   Omura Y., ACUPUNCTURE ELECTROT, V43
   Omura Y., 2018, NUTR INTEGRATIVE MED, P687
   OMURA Y, 1995, ICMART S 2 BULG AC C, P1
   Omura Y, 2001, ACUPUNCTURE ELECTRO, V26, P77
   Omura Y., 2018, ACTA SCI CANC BIOL, V2, P1
   Omura Y, 1986, PRACTICE BIDIGITAL O, P191
   Omura Y, 2015, ACUPUNCTURE ELECTRO, V40, P1, DOI 10.3727/036012915X14279074629589
NR 13
TC 0
Z9 0
U1 2
U2 5
PU COGNIZANT COMMUNICATION CORP
PI PUTNAM VALLEY
PA 18 PEEKSKILL HOLLOW RD, PO BOX 37, PUTNAM VALLEY, NY 10579 USA
SN 0360-1293
EI 2167-9010
J9 ACUPUNCTURE ELECTRO
JI Acupunct. Electro-Ther. Res.
PY 2018
VL 43
IS 4
BP 359
EP 369
DI 10.3727/036012919X15475948072809
PG 11
WC Integrative & Complementary Medicine; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Neurosciences & Neurology
GA HL5RJ
UT WOS:000458787100004
DA 2026-01-16
ER

PT J
AU Brooks, MR
   Golianu, B
AF Brooks, Meredith R.
   Golianu, Brenda
TI Perioperative management in children with chronic pain
SO PEDIATRIC ANESTHESIA
LA English
DT Review
DE pediatric; children; chronic pain; perioperative management;
   opioid-tolerant; surgical
ID PEDIATRIC CHRONIC PAIN; POSTOPERATIVE PAIN; SEROTONIN SYNDROME;
   DOUBLE-BLIND; REGIONAL ANESTHESIA; TOTAL KNEE; FUNCTIONAL CONNECTIVITY;
   LIDOCAINE INFUSION; NEUROPATHIC PAIN; OPIOID-TOLERANT
AB Children with chronic pain often undergo surgery and effective perioperative management of their pain can be challenging. Identification of the pediatric chronic pain patient preoperatively and development of a perioperative pain plan may help ensure a safer and more comfortable perioperative course. Successful management usually requires multiple different classes of analgesics, regional anesthesia, and adjunctive nonpharmacological therapies. Neuropathic and oncological pain can be especially difficult to treat and usually requires an individualized approach.
C1 [Brooks, Meredith R.] Cook Childrens Hosp, Dept Anesthesiol, 901 Seventh Ave, Ft Worth, TX 76104 USA.
   [Golianu, Brenda] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA.
C3 Cook Children's Medical Center; Stanford University
RP Brooks, MR (corresponding author), Cook Childrens Hosp, Dept Anesthesiol, 901 Seventh Ave, Ft Worth, TX 76104 USA.
EM meredith.brooks@cookchildrens.org
OI Brooks, Meredith Rockeymoore/0009-0006-1669-7123
CR Adudu O, 2006, AFR J ANAESTH INT CA, V7, P6
   Ailawadhi S, 2007, J CLIN PHARM THER, V32, P199, DOI 10.1111/j.1365-2710.2007.00813.x
   Allegaert K, 2013, PEDIATR ANESTH, V23, P45, DOI 10.1111/pan.12076
   Altman EM, 2007, PSYCHOSOMATICS, V48, P361, DOI 10.1176/appi.psy.48.4.361-a
   Anderson BJ, 2006, CURR OPIN ANESTHESIO, V19, P285, DOI 10.1097/01.aco.0000192802.33291.6f
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], AM J EMERG MED
   Armaghani SJ, 2016, CLIN SPINE SURG, V29, pE93, DOI 10.1097/BSD.0000000000000109
   Baliki MN, 2012, NAT NEUROSCI, V15, P1117, DOI 10.1038/nn.3153
   Beck SL, 2010, J PAIN SYMPTOM MANAG, V39, P100, DOI 10.1016/j.jpainsymman.2009.06.009
   Birmingham PK, 2001, ANESTHESIOLOGY, V94, P385
   Boostani R, 2012, CASP J INTERN MED, V3, P484
   Brummett CM, 2015, ARTHRITIS RHEUMATOL, V67, P1386, DOI 10.1002/art.39051
   Brummett CM, 2015, ANESTHESIOLOGY, V122, P731, DOI 10.1097/ALN.0000000000000598
   Brummett Chad M, 2009, J Opioid Manag, V5, P175, DOI 10.5055/jom.2009.0018
   Bryson EO, 2014, CURR OPIN ANESTHESIO, V27, P359, DOI 10.1097/ACO.0000000000000052
   Buvanendran A, 2007, BEST PRACT RES-CLIN, V21, P31, DOI 10.1016/j.bpa.2006.12.003
   Cao JP, 2011, PEDIATR ANESTH, V21, P399, DOI 10.1111/j.1460-9592.2011.03543.x
   Carlson J, 2003, J PAIN SYMPTOM MANAG, V25, P264, DOI 10.1016/S0885-3924(02)00677-2
   Carroll IR, 2004, REGION ANESTH PAIN M, V29, P576, DOI 10.1016/j.rapm.2004.06.009
   Chen S, 2016, CLIN J PAIN, V32, P179, DOI 10.1097/AJP.0000000000000218
   Chidambaran V, 2012, INT ANESTHESIOL CLIN, V50, P66, DOI 10.1097/AIA.0b013e31826f3284
   Cho Y, 2015, PAIN PRACT, V5
   Chou R, 2014, J PAIN, V15, P321, DOI 10.1016/j.jpain.2014.01.494
   Clarke H, 2012, ANESTH ANALG, V115, P428, DOI 10.1213/ANE.0b013e318249d36e
   Dadure C, 2009, CAN J ANAESTH, V56, P843, DOI 10.1007/s12630-009-9169-8
   Dahmani S, 2011, PEDIATR ANESTH, V21, P636, DOI 10.1111/j.1460-9592.2011.03566.x
   De Kock MF, 2007, BEST PRACT RES-CLIN, V21, P85, DOI 10.1016/j.bpa.2006.12.006
   De Martin S, 2006, CLIN PHARMACOL THER, V80, P597, DOI 10.1016/j.clpt.2006.08.020
   De Pinto M, 2012, EXPERT REV NEUROTHER, V12, P1325, DOI [10.1586/ERN.12.123, 10.1586/ern.12.123]
   Desarkar P, 2006, EUR CHILD ADOLES PSY, V15, P496, DOI 10.1007/s00787-006-0553-4
   Dharmshaktu P, 2012, J CLIN PHARMACOL, V52, P6, DOI 10.1177/0091270010394852
   DiGiusto M, 2014, J PAIN RES, V7, P471, DOI 10.2147/JPR.S64497
   Dingeman RS, 2013, JAMA SURG, V148, P707, DOI 10.1001/jamasurg.2013.1442
   Duflo F, 2005, ANESTHESIOLOGY, V103, P1253, DOI 10.1097/00000542-200512000-00022
   Ecoffey C, 2010, PEDIATR ANESTH, V20, P1061, DOI 10.1111/j.1460-9592.2010.03448.x
   Evaniew N, 2015, J ORTHOP TRAUMA, V29, pE235, DOI 10.1097/BOT.0000000000000305
   Evans S, 2008, ALTERN THER HEALTH M, V14, P52
   Falk S, 2014, J CLIN ONCOL, V32, P1647, DOI 10.1200/JCO.2013.51.7219
   Fanning JJ, 2012, PEDIATR ANESTH, V22, P203, DOI 10.1111/j.1460-9592.2011.03732.x
   Felden L, 2011, BRIT J ANAESTH, V107, P319, DOI [10.1093/bja/aer232, 10.1093/bja/aer200]
   Finkel JC, 2002, ANESTH ANALG, V94, P1469, DOI 10.1097/00000539-200206000-00017
   Fortier MA, 2011, BRIT J ANAESTH, V106, P713, DOI 10.1093/bja/aer010
   Ganesh A, 2007, ANESTH ANALG, V105, P1234, DOI 10.1213/01.ane.0000284670.17412.b6
   Gasse C, 2000, PHARMACOTHERAPY, V20, P629, DOI 10.1592/phco.20.7.629.35174
   Geary T, 2012, PEDIATR ANESTH, V22, P189, DOI 10.1111/j.1460-9592.2011.03737.x
   Gillman PK, 2005, BRIT J ANAESTH, V95, P434, DOI 10.1093/bja/aei210
   Gohil S, 2012, ANAESTHESIA, V67, P1395, DOI 10.1111/anae.12029
   Gordon DB, 2005, ARCH INTERN MED, V165, P1574, DOI 10.1001/archinte.165.14.1574
   Gordon D, 2008, J PAIN, V9, P383, DOI 10.1016/j.jpain.2008.01.331
   Gritsenko K, 2014, BEST PRACT RES-CLIN, V28, P59, DOI 10.1016/j.bpa.2014.03.001
   Gurnaney H, 2014, ANESTH ANALG, V118, P621, DOI 10.1213/ANE.0b013e3182a08fd4
   Hanasono MM, 2004, ARCH OTOLARYNGOL, V130, P917, DOI 10.1001/archotol.130.8.917
   Hannam JA, 2014, PEDIATR ANESTH, V24, P953, DOI 10.1111/pan.12422
   Hebl AR, 2001, ANESTH ANALG, V92, P249
   Hebl JR, 2008, REGION ANESTH PAIN M, V33, P510, DOI 10.1016/j.rapm.2008.04.008
   Hedén L, 2009, PEDIATR BLOOD CANCER, V53, P1200, DOI 10.1002/pbc.22233
   Hendrich J, 2008, P NATL ACAD SCI USA, V105, P3628, DOI 10.1073/pnas.0708930105
   Hockenberry MJ, 2011, J PEDIAT HEMATOL ONC, V33, P119, DOI 10.1097/MPH.0b013e3181f46a65
   Honarmand A, 2008, PEDIATR ANESTH, V18, P508, DOI 10.1111/j.1460-9592.2008.02461.x
   Hong JY, 2010, J UROLOGY, V183, P1551, DOI 10.1016/j.juro.2009.12.043
   Huguet A, 2008, J PAIN, V9, P226, DOI 10.1016/j.jpain.2007.10.015
   Janda AM, 2015, ANESTHESIOLOGY, V122, P1103, DOI 10.1097/ALN.0000000000000637
   Jin FL, 2001, J CLIN ANESTH, V13, P524, DOI 10.1016/S0952-8180(01)00320-8
   Johnson RE, 2005, J PAIN SYMPTOM MANAG, V29, P297, DOI 10.1016/j.jpainsymman.2004.07.005
   Joly V, 2005, ANESTHESIOLOGY, V103, P147, DOI 10.1097/00000542-200507000-00022
   Kachko L, 2011, PAIN RES MANAG, V16, P457, DOI 10.1155/2011/164984
   Kadiev E, 2008, EXPERT OPIN DRUG MET, V4, P77, DOI [10.1517/17425255.4.1.77, 10.1517/17425255.4.1.77 ]
   Kajiume T, 2012, J PALLIAT MED, V15, P719, DOI 10.1089/jpm.2011.0097
   Kapur BM, 2014, CLIN BIOCHEM, V47, P1169, DOI 10.1016/j.clinbiochem.2014.05.065
   Karunatilake H, 2006, ANN PHARMACOTHER, V40, P155, DOI 10.1345/aph.1E671
   KEHLET H, 1993, ANESTH ANALG, V77, P1048
   Kharasch ED, 2016, ANESTHESIOLOGY, V124, P10, DOI 10.1097/ALN.0000000000000914
   Kim KT, 2014, SPINE J, V14, P1559, DOI 10.1016/j.spinee.2013.09.031
   Kopf A, 2005, BEST PRACT RES-CLIN, V19, P59, DOI 10.1016/j.bpa.2004.08.002
   Krantz MJ, 2005, PHARMACOTHERAPY, V25, P1523, DOI 10.1592/phco.2005.25.11.1523
   Kushimo O, 1998, NIG Q J HOSP MED, V8, P52
   Lai SH, 2006, ANN ACAD MED SINGAP, V35, P508
   Lambert P, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009633.pub2
   Landier W, 2010, J PEDIATR NURS, V25, P566, DOI 10.1016/j.pedn.2010.01.009
   Langford RM, 2006, CLIN RHEUMATOL, V25, pS2, DOI 10.1007/s10067-006-0311-5
   Latham GJ, 2010, PEDIATR ANESTH, V20, P479, DOI 10.1111/j.1460-9592.2010.03261.x
   Lee Dennis, 2014, J Bone Joint Surg Am, V96, pe89
   Lee J, 2009, PSYCHOSOMATICS, V50, P638, DOI 10.1176/appi.psy.50.6.638
   Lin YC, 2009, PEDIATR ANESTH, V19, P1096, DOI 10.1111/j.1460-9592.2009.03129.x
   Linnman C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057205
   Liu WQ, 2014, ACTA NEUROL SCAND, V129, P132, DOI 10.1111/ane.12169
   Liu Y, 2013, PEDIATR ANESTH, V23, P1187, DOI 10.1111/pan.12271
   Loftus RW, 2010, ANESTHESIOLOGY, V113, P639, DOI 10.1097/ALN.0b013e3181e90914
   Lönnqvist PA, 2011, CURR OPIN ANESTHESIO, V24, P627, DOI 10.1097/ACO.0b013e32834a276d
   Lunn TH, 2015, PAIN, V156, P2438, DOI 10.1097/j.pain.0000000000000309
   Martin DP, 2013, PEDIATRICS, V131, pE323, DOI 10.1542/peds.2011-3779
   Mathiesen O, 2014, ACTA ANAESTH SCAND, V58, P1182, DOI 10.1111/aas.12380
   McCarthy GC, 2010, DRUGS, V70, P1149, DOI 10.2165/10898560-000000000-00000
   Mehta S, 2014, ARCH PHYS MED REHAB, V95, P2180, DOI 10.1016/j.apmr.2014.06.010
   Meighen KG, 2007, J CHILD ADOL PSYCHOP, V17, P121, DOI 10.1089/cap.2006.0042
   Menif K, 2011, FETAL PEDIATR PATHOL, V30, P359, DOI 10.3109/15513815.2011.555813
   Mishriky BM, 2015, BRIT J ANAESTH, V114, P10, DOI 10.1093/bja/aeu293
   Moffett BS, 2006, PEDIATR ANESTH, V16, P424, DOI 10.1111/j.1460-9592.2005.01806.x
   Mooney JJ, 2014, PAIN MED, V15, P820, DOI 10.1111/pme.12333
   Moran Lisa R, 2004, J Perinatol, V24, P395, DOI 10.1038/sj.jp.7211123
   Nalamachu SR, 2012, ADV THER, V29, P849, DOI 10.1007/s12325-012-0051-7
   Neri E, 2013, ARCH DIS CHILD, V98, P721, DOI 10.1136/archdischild-2012-303527
   Olorunto WA, 2006, J AM COLL SURGEONS, V202, P169, DOI 10.1016/j.jamcollsurg.2005.08.007
   Pacenta HL, 2010, ANAESTH INTENS CARE, V38, P563, DOI 10.1177/0310057X1003800324
   Page M Gabrielle, 2012, J Pain Res, V5, P547, DOI 10.2147/JPR.S36614
   Patanwala AE, 2007, ANN PHARMACOTHER, V41, P255, DOI 10.1345/aph.1H421
   Patanwala AE, 2008, PHARMACOTHERAPY, V28, P1453, DOI 10.1592/phco.28.12.1453
   Peacock JE, 2000, ANAESTHESIA, V55, P1208, DOI 10.1046/j.1365-2044.2000.01615-4.x
   Perez RS, 2010, BMC NEUROL, V10, DOI 10.1186/1471-2377-10-20
   Perlman R, 2013, PAIN, V154, P2794, DOI 10.1016/j.pain.2013.08.015
   Pettersson PH, 2006, ACTA ANAESTH SCAND, V50, P673, DOI 10.1111/j.1399-6576.2006.01043.x
   Pilgrim JL, 2011, FORENSIC SCI MED PAT, V7, P162, DOI 10.1007/s12024-010-9188-3
   Polaner DM, 2012, ANESTH ANALG, V115, P1353, DOI 10.1213/ANE.0b013e31825d9f4b
   Prakash A, 2012, J CHILD ADOL PSYCHOP, V22, P48, DOI 10.1089/cap.2011.0072
   Rahangdale R, 2014, ANESTH ANALG, V118, P1113, DOI 10.1213/ANE.0000000000000137
   Rastogi R, 2011, ANESTHESIOLOGY, V115, P1291, DOI 10.1097/ALN.0b013e31823940c0
   Rochette A, 2005, PEDIATR ANESTH, V15, P1072, DOI 10.1111/j.1460-9592.2005.01664.x
   Rusy LM, 2002, ANESTHESIOLOGY, V96, P300, DOI 10.1097/00000542-200202000-00013
   Rusy LM, 2010, ANESTH ANALG, V110, P1393, DOI 10.1213/ANE.0b013e3181d41dc2
   Sadhasivam S, 2014, PHARMACOGENOMICS, V15, P277, DOI 10.2217/pgs.13.248
   Sahlsten MJM, 2008, NURS FORUM, V43, P2, DOI 10.1111/j.1744-6198.2008.00090.x
   Schmidt PC, 2013, ANESTHESIOLOGY, V119, P1215, DOI 10.1097/ALN.0b013e3182a9a896
   Schnabel A, 2011, PEDIATR ANESTH, V21, P1219, DOI 10.1111/j.1460-9592.2011.03715.x
   Schwartzman RJ, 2009, PAIN MED, V10, P401, DOI 10.1111/j.1526-4637.2009.00573.x
   Sen S, 2016, CURR PAIN HEADACHE R, V20, DOI 10.1007/s11916-016-0549-9
   Simons LE, 2014, PAIN, V155, P1727, DOI 10.1016/j.pain.2014.05.023
   Singla NK, 2012, PAIN PRACT, V12, P523, DOI 10.1111/j.1533-2500.2012.00556.x
   Sun YX, 2012, DIS COLON RECTUM, V55, P1183, DOI 10.1097/DCR.0b013e318259bcd8
   Sun-Edelstein C, 2008, EXPERT OPIN DRUG SAF, V7, P587, DOI [10.1517/14740338.7.5.587, 10.1517/14740338.7.5.587 ]
   Suresh S, 2008, PEDIATR ANESTH, V18, P884, DOI 10.1111/j.1460-9592.2008.02638.x
   Sutton KG, 2002, BRIT J PHARMACOL, V135, P257, DOI 10.1038/sj.bjp.0704439
   Tashakori A, 2010, CLIN TOXICOL, V48, P337, DOI 10.3109/15563651003709427
   Tsao GJ, 2015, LARYNGOSCOPE, V125, P1972, DOI 10.1002/lary.25252
   Vadivelu Nalini, 2010, Anesthesiol Clin, V28, P601, DOI 10.1016/j.anclin.2010.08.015
   van Rijn MA, 2011, J NEURAL TRANSM, V118, P1301, DOI 10.1007/s00702-011-0601-1
   Vickers A, 2009, CURR MED RES OPIN, V25, P2557, DOI 10.1185/03007990903281059
   Vigneault L, 2011, CAN J ANESTH, V58, P22, DOI 10.1007/s12630-010-9407-0
   Waldron NH, 2013, BRIT J ANAESTH, V110, P191, DOI 10.1093/bja/aes431
   Walker SM, 2012, ANESTH ANALG, V115, P638, DOI 10.1213/ANE.0b013e31826253f2
   Wang SM, 2008, ANESTH ANALG, V107, P811, DOI 10.1213/ane.0b013e3181804441
   Wang SM, 2002, ANESTHESIOLOGY, V97, P359, DOI 10.1097/00000542-200208000-00012
   Weingarten TN, 2015, REGION ANESTH PAIN M, V40, P330, DOI 10.1097/AAP.0000000000000257
   Wolfe F, 2009, ARTHRIT RHEUM-ARTHR, V61, P715, DOI 10.1002/art.24553
   Woolf CJ, 2013, LANCET NEUROL, V12, P18, DOI 10.1016/S1474-4422(12)70287-9
   Wu S, 2009, PEDIATR CRIT CARE ME, V10, P291, DOI 10.1097/PCC.0b013e318198afd6
   Zhou SF, 2009, CLIN PHARMACOKINET, V48, P689, DOI 10.2165/11318030-000000000-00000
NR 147
TC 6
Z9 7
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1155-5645
EI 1460-9592
J9 PEDIATR ANESTH
JI Pediatr. Anesth.
PD AUG
PY 2016
VL 26
IS 8
BP 794
EP 806
DI 10.1111/pan.12948
PG 13
WC Anesthesiology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Pediatrics
GA DR4ZZ
UT WOS:000379913900003
PM 27370517
DA 2026-01-16
ER

PT J
AU Bi, LN
   Gao, WJ
   Zhang, Q
   Li, N
   Zhang, X
   Han, J
AF Bi, Liuna
   Gao, Wenjuan
   Zhang, Qian
   Li, Na
   Zhang, Xian
   Han, Jing
TI Efficacy of Auricular Acupressure Combined With Positive Psychological
   Techniques on Sleep Quality in Cancer Patients Undergoing Radiotherapy:
   A Randomized Controlled Trial
SO CANCER NURSING
LA English
DT Article; Early Access
DE Auricular acupressure; Cancer; Positive psychological techniques; Sleep
   quality
ID POINT ACUPRESSURE; DISTURBANCE; DISTRESS; INSOMNIA; WOMEN; FEAR; PAIN;
   MEN
AB Background: Auricular acupressure (AA) and positive psychological intervention (PPI) are promising sleep improvement methods. Objective: To assess and compare the efficacies of combined intervention (CI [AA + PPI]), AA, and PPI in sleep quality enhancement and their potential effects in alleviating negative psychological states in radiotherapy-treated patients with cancer. Methods: This study was a 4-arm, placebo-controlled randomized trial. We randomly assigned 120 eligible patients into 4 groups (30 patients per group). The main outcomes included subjective sleep quality, psychological distress, and fear of cancer recurrence, which were measured at baseline, immediate postintervention, and 4 weeks postintervention. Objective sleep quality was measured using Fitbit Charge 3 at baseline and immediate postintervention. The intervention effects were estimated using the linear mixed model. Results: The 4 groups demonstrated significant differences in subjective sleep quality (P < .001), psychological distress (P = .004), and fear of cancer recurrence (P < .001). CI, AA, and PPI had different degrees of positive effects on subjective sleep quality compared with sham control; CI was more effective than AA and PPI, whereas AA was more effective than PPI. CI and PPI showed significant and comparable effects on psychological distress and fear of cancer recurrence reduction. Only CI and AA significantly improved the objective sleep quality. Conclusions: CI, AA, and PPI are recommended as complementary therapies to improve the sleep quality of patients with cancer. Implications for Practice: In future clinical practice, healthcare workers should assess patients' sleep quality and psychological status and select appropriate interventions.
C1 [Bi, Liuna; Gao, Wenjuan; Zhang, Qian; Han, Jing] Xuzhou Med Univ, Sch Nursing, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China.
   [Li, Na; Zhang, Xian] Xuzhou Med Univ, Affiliated Hosp, Xuzhou, Peoples R China.
C3 Xuzhou Medical University; Xuzhou Medical University
RP Han, J (corresponding author), Xuzhou Med Univ, Sch Nursing, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China.
EM biliunana@163.com; xiaocaihua666@163.com; zl15062140573@163.com;
   18361278151@163.com; 330820068@qq.com; jingandyang@163.com
RI Gao, Wenjuan/GYU-1939-2022
FU National Natural Science Foundation of China [72204209]; Jiangsu
   Postdoctoral Research Funding Program [2021K624C]
FX This study was funded by the National Natural Science Foundation of
   China (grant 72204209) and the Jiangsu Postdoctoral Research Funding
   Program (grant 2021K624C).
CR Bahcecioglu Turan Gulcan, 2023, Cancer Nurs, V46, P457, DOI 10.1097/NCC.0000000000001193
   Bi LN, 2023, ASIA-PAC J ONCOL NUR, V10, DOI 10.1016/j.apjon.2023.100308
   Chen YC, 2022, CANCERS, V14, DOI 10.3390/cancers14030798
   Cheung DST, 2023, WORLDV EVID-BASED NU, V20, P202, DOI 10.1111/wvn.12617
   Dong YS, 2024, ANAESTH CRIT CARE PA, V43, DOI 10.1016/j.accpm.2024.101358
   Fabian A, 2023, J CANCER RES CLIN, V149, P9017, DOI 10.1007/s00432-023-04837-5
   Garland SN, 2023, SLEEP MED, V109, P293, DOI 10.1016/j.sleep.2023.07.017
   Hao P., 2023, Chinese Nursing Research, V37, P3975
   Hickok JT, 2005, J PAIN SYMPTOM MANAG, V30, P433, DOI 10.1016/j.jpainsymman.2005.04.012
   Höxtermann MD, 2021, CANCERS, V13, DOI 10.3390/cancers13164082
   Hou PW, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/495684
   Huang N., 2021, Chin J Cancer Prev Treat, V28, P1882
   Jones CL, 2015, HEALTH COMMUN, V30, P566, DOI 10.1080/10410236.2013.873363
   Kung YY, 2011, MENOPAUSE, V18, P638, DOI 10.1097/gme.0b013e31820159c1
   Kuo HC, 2018, RES NURS HEALTH, V41, P469, DOI 10.1002/nur.21885
   Lebel S, 2016, SUPPORT CARE CANCER, V24, P3265, DOI 10.1007/s00520-016-3272-5
   Liu QX, 2022, EUR J ONCOL NURS, V61, DOI 10.1016/j.ejon.2022.102219
   Liu XC., 1996, Chin. J. Psychiatry, V29, P103
   Matthews EE, 2022, SEMIN ONCOL NURS, V38, DOI 10.1016/j.soncn.2022.151253
   Miaskowski C, 2011, SLEEP, V34, P171, DOI 10.1093/sleep/34.2.171
   Mitchell AJ, 2010, J NATL COMPR CANC NE, V8, P487, DOI 10.6004/jnccn.2010.0035
   Oleson T., 2014, Auriculotherapy Manual: Chinese and Western Systems of Ear Acupuncture
   Otto AK, 2016, HEALTH PSYCHOL, V35, P1320, DOI 10.1037/hea0000400
   Ou YX, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1108686
   Peng S., 2016, Chin Nurs Res, V30, P1272
   Peoples AR, 2021, J PAIN SYMPTOM MANAG, V61, P254, DOI 10.1016/j.jpainsymman.2020.07.041
   Perndorfer C, 2022, ANN BEHAV MED, V56, P1131, DOI 10.1093/abm/kaac018
   Rades D, 2021, ANTICANCER RES, V41, P2489, DOI 10.21873/anticanres.15026
   Riba Michelle B, 2019, J Natl Compr Canc Netw, V17, P1229, DOI 10.6004/jnccn.2019.0048
   Roth AJ, 1998, CANCER, V82, P1904, DOI 10.1002/(SICI)1097-0142(19980515)82:10<1904::AID-CNCR13>3.0.CO;2-X
   Ruel S, 2020, HEALTH PSYCHOL, V39, P358, DOI 10.1037/hea0000811
   Seligman MEP, 2005, AM PSYCHOL, V60, P410, DOI 10.1037/0003-066X.60.5.410
   Seligman MEP, 2000, AM PSYCHOL, V55, P5, DOI 10.1037/0003-066X.55.1.5
   Seo YS, 2018, CANCER RES TREAT, V50, P345, DOI 10.4143/crt.2017.096
   Steptoe A, 2008, J PSYCHOSOM RES, V64, P409, DOI 10.1016/j.jpsychores.2007.11.008
   Tan TT, 2023, BMJ SUPPORT PALLIAT, V13, pE389, DOI 10.1136/bmjspcare-2021-003068
   Vallance JKH, 2007, J CLIN ONCOL, V25, P2352, DOI 10.1200/JCO.2006.07.9988
   Van Onselen C, 2010, EUR J ONCOL NURS, V14, P373, DOI 10.1016/j.ejon.2009.12.002
   Wang J, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.648896
   Wang YX, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/3996101
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Yeh CH, 2013, MED ACUPUNCT, V25, P423, DOI 10.1089/acu.2013.1006
   Yoon HG, 2019, APPL NURS RES, V48, P45, DOI 10.1016/j.apnr.2019.05.009
   Zhang JH, 2020, COMPLEMENT THER CLIN, V41, DOI 10.1016/j.ctcp.2020.101253
   Zhang QW., 2021, Chin J Mod Nurs, V27, P3986
   Zhang Y, 2023, SUPPORT CARE CANCER, V31, DOI 10.1007/s00520-023-08053-2
   Zhang YF, 2019, Chin J Hygiene Rescue (Electronic Edition), V5, P157, DOI 10.3877/cma.j.issn.2095-9133.2019.03.007
NR 47
TC 1
Z9 1
U1 6
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD 2024 DEC 10
PY 2024
DI 10.1097/NCC.0000000000001436
EA DEC 2024
PG 9
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA O9U0O
UT WOS:001374477000001
PM 39655909
DA 2026-01-16
ER

PT J
AU Lee, JH
   Li, DX
   Yoon, H
   Go, D
   Quan, FS
   Min, BI
   Kim, SK
AF Lee, Ji-Hye
   Li, Dong Xing
   Yoon, Heera
   Go, Donghyun
   Quan, Fu Shi
   Min, Byung-Il
   Kim, Sun Kwang
TI Serotonergic mechanism of the relieving effect of bee venom acupuncture
   on oxaliplatin-induced neuropathic cold allodynia in rats
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Bee venom acupuncture; Cold allodynia; Oxaliplatin; Rat; Serotonin
ID INDUCED PERIPHERAL NEUROPATHY; RECEPTOR SUBTYPES; 5-HT3 RECEPTORS; PAIN;
   STIMULATION; MODEL; TRANSMISSION; ANTINOCICEPTION; CHEMOTHERAPY;
   APIPUNCTURE
AB Background: Oxaliplatin, an important chemotherapy drug for advanced colorectal cancer, often induces peripheral neuropathy, especially cold allodynia. Our previous study showed that bee venom acupuncture (BVA), which has been traditionally used in Korea to treat various pain symptoms, potently relieves oxaliplatin-induced cold allodynia in rats. However, the mechanism for this anti-allodynic effect of BVA remains poorly understood. We investigated whether and how the central serotonergic system, a well-known pathway for acupuncture analgesia, mediates the relieving effect of BVA on cold allodynia in oxaliplatin-injected rats.
   Methods: The behavioral signs of cold allodynia in Sprague-Dawley (SD) rats were induced by a single injection of oxaliplatin (6 mg/kg, i.p.). Before and after BVA treatment, the cold allodynia signs were evaluated by immersing the rat's tail into cold water (4 degrees C) and measuring the withdrawal latency. For BVA treatment, a diluted BV (0.25 mg/kg) was subcutaneously administered into Yaoyangguan (GV3) acupoint, which is located between the spinous processes of the fourth and the fifth lumbar vertebra. Serotonin was depleted by a daily injection of DL-p-chlorophenylalanine (PCPA, 150 mg/kg, i.p.) for 3 days. The amount of serotonin in the spinal cord was measured by ELISA. Serotonergic receptor antagonists were administered intraperitoneally or intrathecally before BVA treatment.
   Results: The serotonin levels in the spinal cord were significantly increased by BVA treatment and such increase was significantly reduced by PCPA. This PCPA pretreatment abolished the relieving effect of BVA on oxaliplatin-induced cold allodynia. Either of methysergide (mixed 5-HT1/5-HT2 receptor antagonist, 1 mg/kg, i.p.) or MDL-72222 (5-HT3 receptor antagonist, 1 mg/kg, i.p) blocked the anti-allodynic effect of BVA. Further, an intrathecal injection of MDL-72222 (12 mu g) completely blocked the BVA-induced anti-allodynic action, whereas NAN-190 (5-HT1A receptor antagonist, 15 mu g, i.t.) or ketanserin (5-HT2A receptor antagonist, 30 mu g, i.t.) did not.
   Conclusions: These results suggest that BVA treatment alleviates oxaliplatin-induced acute cold allodynia in rats via activation of the serotonergic system, especially spinal 5-HT3 receptors. Thus, our findings may provide a clinically useful evidence for the application of BVA as an alternative therapeutic option for the management of peripheral neuropathy, a dose-limiting side effect that occurs after an administration of oxaliplatin.
C1 [Lee, Ji-Hye; Go, Donghyun; Min, Byung-Il; Kim, Sun Kwang] Kyung Hee Univ, Grad Sch, Dept East West Med, Seoul 130701, South Korea.
   [Li, Dong Xing; Yoon, Heera; Kim, Sun Kwang] Kyung Hee Univ, Coll Korean Med, Dept Physiol, Seoul 130701, South Korea.
   [Quan, Fu Shi] Kyung Hee Univ, Sch Med, Dept Med Zool, Seoul 130701, South Korea.
   [Min, Byung-Il] Kyung Hee Univ, Sch Med, Dept Physiol, Seoul 130701, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University; Kyung
   Hee University
RP Kim, SK (corresponding author), Kyung Hee Univ, Grad Sch, Dept East West Med, Seoul 130701, South Korea.
EM skkim77@khu.ac.kr
RI Quan, Fu-Shi/V-1826-2019; MIN, B. I./U-3364-2017; Kim, Sun/AAM-1289-2020
FU National Research Foundation of Korea (NRF) grant - Korea government
   [NRF-2013R1A1A1012403]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (NRF-2013R1A1A1012403). We
   thank Drs. Lee G, Moon HJ, Lim BS and Kim WJ for excellent technical
   supports and discussions on the experiments and manuscript.
CR AIMONE LD, 1987, PAIN, V31, P123, DOI 10.1016/0304-3959(87)90012-1
   [Anonymous], EVID BASED COMPLEMEN
   Argyriou AA, 2013, EUR J NEUROL, V20, P788, DOI 10.1111/ene.12061
   Argyriou AA, 2012, CRIT REV ONCOL HEMAT, V82, P51, DOI 10.1016/j.critrevonc.2011.04.012
   Baek YH, 2006, BRAIN RES, V1073, P305, DOI 10.1016/j.brainres.2005.12.086
   Bardin L, 1997, EXP BRAIN RES, V113, P81, DOI 10.1007/BF02454144
   Bardin L, 2011, BEHAV PHARMACOL, V22, P390, DOI 10.1097/FBP.0b013e328349aae4
   Bilge SS, 2012, EUR J PHARMACOL, V681, P44, DOI 10.1016/j.ejphar.2012.01.043
   BILLINGHAM ME, 1973, NATURE, V245, P163, DOI 10.1038/245163a0
   Broomand A, 2009, J NEGAT RESULTS BIOM, V8, DOI 10.1186/1477-5751-8-2
   De la Calle JL, 2002, BRAIN RES BULL, V59, P245, DOI 10.1016/S0361-9230(02)00866-3
   Giordano James, 2004, Pain Physician, V7, P141
   GLOWINSKI J, 1966, J NEUROCHEM, V13, P655, DOI 10.1111/j.1471-4159.1966.tb09873.x
   HAMMOND DL, 1984, BRAIN RES, V298, P329, DOI 10.1016/0006-8993(84)91432-X
   Jeong HJ, 2012, BRIT J PHARMACOL, V165, P1956, DOI 10.1111/j.1476-5381.2011.01685.x
   Kang SY, 2012, J PAIN, V13, P155, DOI 10.1016/j.jpain.2011.10.012
   Kang SY, 2011, BRAIN RES BULL, V86, P412, DOI 10.1016/j.brainresbull.2011.08.012
   Kim HW, 2005, PHARMACOL RES, V51, P183, DOI 10.1016/j.phrs.2004.07.011
   Kim SK, 2005, EXP NEUROL, V195, P430, DOI 10.1016/j.expneurol.2005.06.018
   Kim YI, 1997, NEUROREPORT, V8, P2149, DOI 10.1097/00001756-199707070-00011
   Kwon YB, 2001, NEUROSCI LETT, V308, P133, DOI 10.1016/S0304-3940(01)01989-9
   Lim BS, 2013, EVID-BASED COMPL ALT, V2013, DOI DOI 10.1155/2013/36932424058370
   Ling B, 2008, NEUROPHARMACOLOGY, V55, P724, DOI 10.1016/j.neuropharm.2008.06.007
   Ling B, 2007, TOXICOLOGY, V234, P176, DOI 10.1016/j.tox.2007.02.013
   Maleki N, 2005, INT IMMUNOPHARMACOL, V5, P1723, DOI 10.1016/j.intimp.2005.05.012
   Mannelli LD, 2013, J PAIN, V14, P1585, DOI 10.1016/j.jpain.2013.08.002
   MJELLEM N, 1993, BRAIN RES, V626, P78, DOI 10.1016/0006-8993(93)90565-5
   Moon HJ, 2014, J PHYSIOL SCI, V64, P151, DOI 10.1007/s12576-013-0297-0
   NA HS, 1994, NEUROSCI LETT, V177, P50, DOI 10.1016/0304-3940(94)90042-6
   Paul D, 2001, J PHARMACOL EXP THER, V298, P674
   Radhakrishnan R, 2003, PAIN, V105, P205, DOI 10.1016/S0304-3959(03)00207-0
   Renn CL, 2011, MOL PAIN, V7, DOI 10.1186/1744-8069-7-29
   Roh DH, 2004, J PAIN, V5, P297, DOI 10.1016/j.jpain.2004.05.003
   Sasaki M, 2001, EUR J PHARMACOL, V424, P45, DOI 10.1016/S0014-2999(01)01117-7
   SCHMAUSS C, 1983, EUR J PHARMACOL, V90, P349, DOI 10.1016/0014-2999(83)90556-3
   SOLOMON RE, 1989, J PHARMACOL EXP THER, V251, P27
   SOMERFIELD SD, 1988, J RHEUMATOL, V15, P1878
   Wilson RH, 2002, J CLIN ONCOL, V20, P1767, DOI 10.1200/JCO.2002.07.056
   Wolf S, 2008, EUR J CANCER, V44, P1507, DOI 10.1016/j.ejca.2008.04.018
   Xie DJ, 2012, MOL PAIN, V8, DOI 10.1186/1744-8069-8-58
   Yin CS, 2008, RES VET SCI, V84, P159, DOI 10.1016/j.rvsc.2007.04.004
   Yoon SY, 2013, BIOL PHARM BULL, V36, P1787, DOI 10.1248/bpb.b13-00469
   Zedan AH, 2014, CLIN COLORECTAL CANC, V13, P73, DOI 10.1016/j.clcc.2013.11.004
   Zhu JX, 2001, J PHYSIOL-LONDON, V530, P431, DOI 10.1111/j.1469-7793.2001.0431k.x
   ZIMMERMANN M, 1983, PAIN, V16, P109, DOI 10.1016/0304-3959(83)90201-4
NR 45
TC 38
Z9 44
U1 1
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD DEC 6
PY 2014
VL 14
AR 471
DI 10.1186/1472-6882-14-471
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AX0WM
UT WOS:000346670600002
PM 25481535
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lyman, GH
   Greenlee, H
   Bohlke, K
   Bao, T
   DeMichele, AM
   Deng, GE
   Fouladbakhsh, JM
   Gil, B
   Hershman, DL
   Mansfield, S
   Mussallem, DM
   Mustian, KM
   Price, E
   Rafte, S
   Cohen, L
AF Lyman, Gary H.
   Greenlee, Heather
   Bohlke, Kari
   Bao, Ting
   DeMichele, Angela M.
   Deng, Gary E.
   Fouladbakhsh, Judith M.
   Gil, Brigitte
   Hershman, Dawn L.
   Mansfield, Sami
   Mussallem, Dawn M.
   Mustian, Karen M.
   Price, Erin
   Rafte, Susan
   Cohen, Lorenzo
TI Integrative Therapies During and After Breast Cancer Treatment: ASCO
   Endorsement of the SIO Clinical Practice Guideline
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID INDUCED PERIPHERAL NEUROPATHY; ESTROGEN-RECEPTOR-ALPHA; AMERICAN
   SOCIETY; CHEMOTHERAPY; SURVIVORS; GINSENG; ACUPRESSURE; MANAGEMENT;
   NAUSEA; TRIAL
AB PurposeThe Society for Integrative Oncology (SIO) produced an evidence-based guideline on use of integrative therapies during and after breast cancer treatment that was determined to be relevant to the American Society of Clinical Oncology (ASCO) membership. ASCO considered the guideline for endorsement.MethodsThe SIO guideline addressed the use of integrative therapies for the management of symptoms and adverse effects, such as anxiety and stress, mood disorders, fatigue, quality of life, chemotherapy-induced nausea and vomiting, lymphedema, chemotherapy-induced peripheral neuropathy, pain, and sleep disturbance. Interventions of interest included mind and body practices, natural products, and lifestyle modifications. SIO systematic reviews focused on randomized controlled trials that were published from 1990 through 2015. The SIO guideline was reviewed by ASCO content experts for clinical accuracy and by ASCO methodologists for developmental rigor. On favorable review, an ASCO Expert Panel was convened to review the guideline contents and recommendations.ResultsThe ASCO Expert Panel determined that the recommendations in the SIO guidelinepublished in 2017are clear, thorough, and based on the most relevant scientific evidence. ASCO endorsed the guideline with a few added discussion points.RecommendationsKey recommendations include the following: Music therapy, meditation, stress management, and yoga are recommended for anxiety/stress reduction. Meditation, relaxation, yoga, massage, and music therapy are recommended for depression/mood disorders. Meditation and yoga are recommended to improve quality of life. Acupressure and acupuncture are recommended for reducing chemotherapy-induced nausea and vomiting. Acetyl-l-carnitine is not recommended to prevent chemotherapy-induced peripheral neuropathy because of a possibility of harm. No strong evidence supports the use of ingested dietary supplements to manage breast cancer treatment-related adverse effects. Additional information is available at: www.asco.org/supportive-care-guidelines.
C1 [Lyman, Gary H.; Greenlee, Heather] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
   [Lyman, Gary H.; Greenlee, Heather] Univ Washington, Seattle, WA 98195 USA.
   [Bohlke, Kari] Amer Soc Clin Oncol, Alexandria, VA USA.
   [Bao, Ting; Deng, Gary E.] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
   [Hershman, Dawn L.] Columbia Univ, Med Ctr, New York, NY USA.
   [Mustian, Karen M.] Univ Rochester, Med Ctr, Rochester, NY 14642 USA.
   [DeMichele, Angela M.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Fouladbakhsh, Judith M.] Oakland Univ, Rochester, MI 48063 USA.
   [Gil, Brigitte] Lahey Hosp & Med Ctr, Burlington, MA USA.
   [Mansfield, Sami] Canc Wellness Life, Shawnee, KS USA.
   [Mansfield, Sami] Sarah Cannon Canc Inst, Kansas City, MO USA.
   [Mussallem, Dawn M.] Mayo Clin, Jacksonville, FL 32224 USA.
   [Price, Erin] Smith Ctr Healing & Arts, Washington, DC USA.
   [Cohen, Lorenzo] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
C3 Fred Hutchinson Cancer Center; University of Washington; University of
   Washington Seattle; American Society of Clinical Oncology; Memorial
   Sloan Kettering Cancer Center; Columbia University; University of
   Rochester; University of Pennsylvania; Oakland University; Lahey
   Hospital & Medical Center; Sarah Cannon Research Institute; Mayo Clinic;
   University of Texas System; UTMD Anderson Cancer Center
RP Lyman, GH (corresponding author), Amer Soc Clin Oncol, 2318 Mill Rd,Suite 800, Alexandria, VA 22314 USA.
EM guidelines@asco.org
RI ; Hershman, Dawn/AAG-2114-2020; Lyman, Gary/K-5227-2019; Greenlee,
   Heather/A-1439-2011
OI Bao, Ting/0000-0003-4437-2597; 
FU Amgen (Inst); Pfizer (Inst); Genentech (Inst); Incyte (Inst); Veridex
   (Inst); Calithera Biosciences (Inst)
FX Amgen (Inst)Pfizer (Inst), Genentech (Inst), Incyte (Inst), Veridex
   (Inst), Calithera Biosciences (Inst)
CR Ali S, 2000, J MAMMARY GLAND BIOL, V5, P271, DOI 10.1023/A:1009594727358
   Barton DL, 2013, JNCI-J NATL CANCER I, V105, P1230, DOI 10.1093/jnci/djt181
   Barton DL, 2010, SUPPORT CARE CANCER, V18, P179, DOI 10.1007/s00520-009-0642-2
   Beith JM, 2012, MED ACUPUNCT, V24, P241, DOI 10.1089/acu.2012.0876
   Boon Heather S, 2007, BMC Womens Health, V7, P4, DOI 10.1186/1472-6874-7-4
   Dechering K, 2000, CURR MED CHEM, V7, P561, DOI 10.2174/0929867003375010
   Dibble S L, 2000, Oncol Nurs Forum, V27, P41
   Dibble SL, 2007, ONCOL NURS FORUM, V34, P815, DOI 10.1188/07.ONF.813-820
   Duda RB, 2001, J KOREAN MED SCI, V16, pS54, DOI 10.3346/jkms.2001.16.S.S54
   Duda RB, 1996, ANN SURG ONCOL, V3, P515, DOI 10.1007/BF02306082
   Ferrell BR, 2017, J CLIN ONCOL, V35, P96, DOI 10.1200/JCO.2016.70.1474
   Gilligan T, 2017, J CLIN ONCOL, V35, P3618, DOI 10.1200/JCO.2017.75.2311
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Greenlee Heather, 2014, Journal of the National Cancer Institute Monographs, P346, DOI 10.1093/jncimonographs/lgu041
   Greenlee H, 2009, BREAST CANCER RES TR, V117, P653, DOI 10.1007/s10549-009-0315-3
   Harris DM, 2005, EXP BIOL MED, V230, P558, DOI 10.1177/153537020523000807
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   HERSHMAN DL, 2017, SAN ANT BREAST CANC
   Hesketh PJ, 2017, J CLIN ONCOL, V35, P3240, DOI 10.1200/JCO.2017.74.4789
   Irwin MR, 2017, J CLIN ONCOL, V35, P2656, DOI 10.1200/JCO.2016.71.0285
   Johannsen M, 2016, J CLIN ONCOL, V34, P3390, DOI 10.1200/JCO.2015.65.0770
   King ML, 2006, INTEGR CANCER THER, V5, P236, DOI 10.1177/1534735406291341
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Link AR, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/301549
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P3, DOI 10.1016/j.ctim.2006.07.005
   National Cancer Institute, MISTL EXTR PDQ HLTH
   Paice JA, 2016, J CLIN ONCOL, V34, P3325, DOI 10.1200/JCO.2016.68.5206
   Prinsloo S, 2017, CANCER-AM CANCER SOC, V123, P1989, DOI 10.1002/cncr.30649
   Runowicz CD, 2016, J CLIN ONCOL, V34, P611, DOI 10.1200/JCO.2015.64.3809
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   Shojania KG, 2007, ANN INTERN MED, V147, P224, DOI 10.7326/0003-4819-147-4-200708210-00179
   U.S. Preventive Services Task Force, Grade definitions
   Witt CM, 2017, J NATL CANC I MONOGR, V2017
   Wolf JR, 2018, SUPPORT CARE CANCER, V26, P1543, DOI 10.1007/s00520-017-3957-4
   Wyatt G, 2017, J PAIN SYMPTOM MANAG, V54, P670, DOI 10.1016/j.jpainsymman.2017.07.037
   Zhang FF, 2017, CANCER-AM CANCER SOC, V123, P2070, DOI 10.1002/cncr.30615
   Zhang LJ, 2016, LYMPHAT RES BIOL, V14, P104, DOI 10.1089/lrb.2015.0036
   Ziaei Samira, 2017, Medicines (Basel), V4, DOI [10.3390/medicines4020018, 10.3390/medicines4020018]
   Zick SM, 2016, JAMA ONCOL, V2, P1470, DOI 10.1001/jamaoncol.2016.1867
NR 39
TC 294
Z9 333
U1 6
U2 139
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD SEP 1
PY 2018
VL 36
IS 25
BP 2647
EP +
DI 10.1200/JCO.2018.79.2721
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GU9MB
UT WOS:000445669200011
PM 29889605
DA 2026-01-16
ER

PT J
AU Halsey, EJ
   Xing, M
   Stockley, RC
AF Halsey, Elizabeth J.
   Xing, Mei
   Stockley, Rachel C.
TI Acupuncture for joint symptoms related to aromatase inhibitor therapy in
   postmenopausal women with early-stage breast cancer: a narrative review
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE ACUPUNCTURE
ID MUSCULOSKELETAL SYMPTOMS; INDUCED ARTHRALGIA; RANDOMIZED-TRIAL;
   DOUBLE-BLIND; TAMOXIFEN; ANASTROZOLE; EXEMESTANE; LETROZOLE; SURVIVORS;
   PAIN
AB Background Aromatase inhibitor-induced musculoskeletal syndrome (AIMSS) leads to discontinuation of aromatase inhibitor therapy in a significant proportion of patients with breast cancer. Acupuncture is popular among cancer patients and has previously been shown to improve symptoms in a range of musculoskeletal complaints.
   Aim To determine the effectiveness and safety of acupuncture for the management of AIMSS in postmenopausal women with early-stage breast cancer.
   Methods A literature search was carried out for randomised controlled trials (RCTs) on acupuncture for AIMSS in postmenopausal women with early-stage breast cancer. Characteristics of trials and outcomes were extracted from the retrieved articles, which were also assessed for risk of bias and quality of reporting.
   Results Four RCTs were retrieved of sample size 32-67 (totalling 190 participants). Compliance with treatment was high and rates of adverse events were low. Of the three two-arm RCTs, two found no difference between acupuncture and sham acupuncture and one found that acupuncture was statistically superior to sham acupuncture. The fourth RCT, which incorporated three arms, found acupuncture and sham acupuncture to be statistically superior to usual care but there was no difference between true and sham acupuncture. Three trials that used non-penetrating sham as the control found no effect of acupuncture over sham, but the one trial that used superficial needle insertion found acupuncture to be superior.
   Conclusions Acupuncture is safe and results in improvement in AIMSS symptoms, but similar benefits are also elicited by non-penetrating sham acupuncture. Future research should seek to establish the durability of improvements.
C1 [Halsey, Elizabeth J.; Xing, Mei; Stockley, Rachel C.] Manchester Metropolitan Univ, Dept Hlth Profess, Manchester M15 6GX, Lancs, England.
C3 Manchester Metropolitan University
RP Halsey, EJ (corresponding author), Manchester Metropolitan Univ, Dept Hlth Profess, Birley Bldg,Manchester Campus,Bonsall St, Manchester M15 6GX, Lancs, England.
EM Elizabeth.j.halsey@stu.mmu.ac.uk
RI Stockley, Rachel C/AAH-9346-2020
OI Stockley, Rachel C/0000-0003-4441-6860
CR Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Baum M, 2002, LANCET, V359, P2131
   Briot K, 2010, BREAST CANCER RES TR, V120, P127, DOI 10.1007/s10549-009-0692-7
   García MC, 2014, ENCYCLOP MATH APPL, V154, P1
   Coleman RE, 2008, CANCER TREAT REV, V34, P275, DOI 10.1016/j.ctrv.2007.10.004
   Coombes RC, 2004, NEW ENGL J MED, V350, P1081, DOI 10.1056/NEJMoa040331
   Crew KD, 2007, J CLIN ONCOL, V25, P3877, DOI 10.1200/JCO.2007.10.7573
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Din OS, 2010, BREAST CANCER RES TR, V120, P525, DOI 10.1007/s10549-010-0757-7
   Dizdar O, 2009, J CLIN ONCOL, V27, P4955, DOI 10.1200/JCO.2008.20.5435
   Filshie Jacqueline, 2005, Acupunct Med, V23, P171
   Furlan AD, 2009, SPINE, V34, P1929, DOI 10.1097/BRS.0b013e3181b1c99f
   Galantino ML, 2013, ALTERN THER HEALTH M, V19, P38
   Galantino ML, 2012, INTEGR CANCER THER, V11, P313, DOI 10.1177/1534735411413270
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Kaptchuk TJ, 2008, BMJ-BRIT MED J, V336, P999, DOI 10.1136/bmj.39524.439618.25
   Kaptchuk TJ, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015591
   Kubo M, 2012, ANTICANCER RES, V32, P2331
   Langevin HM, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1155/2011/180805
   Lumachi F, 2013, CURR MED CHEM, V20, P596, DOI 10.2174/092986713804999303
   MacPherson H, 2001, COMPLEMENT THER MED, V9, P246, DOI 10.1054/ctim.2001.0488
   MacPherson H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093739
   MacPherson H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077438
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Mao JJ, 2009, CANCER, V115, P3631, DOI 10.1002/cncr.24419
   Molassiotis A, 2006, SUPPORT CARE CANCER, V14, P260, DOI 10.1007/s00520-005-0883-7
   Morales L, 2007, BREAST CANCER RES TR, V104, P87, DOI 10.1007/s10549-006-9394-6
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Office for National Statistics, 2012, CANC REG STAT
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Partridge AH, 2008, J CLIN ONCOL, V26, P556, DOI 10.1200/JCO.2007.11.5451
   Rastelli AL, 2011, BREAST CANCER RES TR, V129, P107, DOI 10.1007/s10549-011-1644-6
   Stan D, 2013, HEMATOL ONCOL CLIN N, V27, P805, DOI 10.1016/j.hoc.2013.05.005
   Swenson KK, 2013, ONCOL NURS FORUM, V40, P549, DOI 10.1188/13.ONF.549-557
   Teig Silje, 2006, Acupunct Med, V24, P80
   Thürlimann B, 2005, NEW ENGL J MED, V353, P2747
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
NR 37
TC 9
Z9 11
U1 0
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD JUN
PY 2015
VL 33
IS 3
BP 188
EP 195
DI 10.1136/acupmed-2014-010735
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CM2QO
UT WOS:000357526900003
PM 25733539
DA 2026-01-16
ER

PT J
AU Lahoud, MJ
   Kourie, HR
   Antoun, J
   El Osta, L
   Ghosn, M
AF Lahoud, Marie Jose
   Kourie, Hampig Raphael
   Antoun, Joelle
   El Osta, Lana
   Ghosn, Marwan
TI Road map for pain management in pancreatic cancer: A review
SO WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
LA English
DT Review
DE Pain management; Interventional; Medical; Treatment; Pancreatic cancer
ID PLACEBO-CONTROLLED TRIAL; CELIAC PLEXUS BLOCK; ENDOSCOPIC ULTRASOUND;
   NEUROPATHIC PAIN; DOUBLE-BLIND; PREGABALIN; MORPHINE; SURVIVAL;
   ADENOCARCINOMA; INNERVATION
AB Beside its poor prognosis and its late diagnosis, pancreatic cancer remains one of the most painful malignancies. Optimal management of pain in this cancer represents a real challenge for the oncologist whose objective is to ensure a better quality of life to his patients. We aimed in this paper to review all the treatment modalities incriminated in the management of pain in pancreatic cancer going from painkillers, chemotherapy, radiation therapy and interventional techniques to agents under investigation and alternative medicine. Although specific guidelines and recommendations for pain management in pancreatic cancer are still absent, we present all the possible pain treatments, with a progression from medical multimodal treatment to radiotherapy and chemotherapy then interventional techniques in case of resistance. In addition, alternative methods such as acupuncture and hypnosis can be added at any stage and seems to contribute to pain relief.
C1 [Lahoud, Marie Jose] St Joseph Univ, Dept Anesthesiol & Crit Care, Fac Med, Beirut 166830, Lebanon.
   [Kourie, Hampig Raphael; Antoun, Joelle; El Osta, Lana; Ghosn, Marwan] St Joseph Univ, Dept Oncol, Fac Med, Monot St, Beirut 166830, Lebanon.
RP Ghosn, M (corresponding author), St Joseph Univ, Dept Oncol, Fac Med, Monot St, Beirut 166830, Lebanon.
EM marwanghosnmd@yahoo.com
RI El Osta, Lana/HKF-3509-2023
CR Abdalla EK, 1999, J GASTROINTEST SURG, V3, P668, DOI 10.1016/S1091-255X(99)80091-2
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], 2023, J Clin, DOI DOI 10.3322/CAAC.21772
   BOCKMAN DE, 1994, GASTROENTEROLOGY, V107, P219, DOI 10.1016/0016-5085(94)90080-9
   Burris HA, 1997, J CLIN ONCOL, V15, P2403, DOI 10.1200/JCO.1997.15.6.2403
   Burton AW, 2004, PAIN MED, V5, P239, DOI 10.1111/j.1526-4637.2004.04037.x
   Buscail L, 2006, PANCREATOLOGY, V6, P7, DOI 10.1159/000090022
   Cabioglu MT, 2008, AM J CHINESE MED, V36, P473, DOI 10.1142/S0192415X08005916
   Call TR, 2015, ANESTHESIOLOGY, V122, P317, DOI 10.1097/ALN.0000000000000489
   Caraceni A, 1999, J PAIN SYMPTOM MANAG, V17, P441, DOI 10.1016/S0885-3924(99)00033-0
   Caratozzolo M, 1997, SURG ENDOSC-ULTRAS, V11, P239, DOI 10.1007/s004649900334
   Ceyhan GO, 2008, BIOCHEM BIOPH RES CO, V374, P442, DOI 10.1016/j.bbrc.2008.07.035
   Ceyhan GO, 2009, GASTROENTEROLOGY, V136, P177, DOI 10.1053/j.gastro.2008.09.029
   Ceyhan GO, 2006, ANN SURG, V244, P274, DOI 10.1097/01.sla.0000217642.68697.55
   Chen H, 2013, PANCREATOLOGY, V13, P594, DOI 10.1016/j.pan.2013.10.007
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Collins D, 2006, ENDOSCOPY, V38, P935, DOI 10.1055/s-2006-944734
   Conroy T, 2011, NEW ENGL J MED, V364, P1817, DOI 10.1056/NEJMoa1011923
   D'Haese JG, 2014, WORLD J GASTROENTERO, V20, P9154, DOI 10.3748/wjg.v20.i27.9154
   DAVIES DD, 1993, J ROY SOC MED, V86, P264
   Eibl G, 2005, PANCREAS, V31, P258, DOI 10.1097/01.mpa.0000175176.40045.0f
   EISENBERG E, 1995, ANESTH ANALG, V80, P290, DOI 10.1097/00000539-199502000-00015
   Eyigor C, 2010, J BUON, V15, P543
   Fink K, 2002, NEUROPHARMACOLOGY, V42, P229, DOI 10.1016/S0028-3908(01)00172-1
   Friess H, 1999, ANN SURG, V230, P615, DOI 10.1097/00000658-199911000-00002
   Friess H, 2003, LAB INVEST, V83, P731, DOI 10.1097/01.LAB.0000067499.57309.F6
   Furness JB, 2014, ADV EXP MED BIOL, V817, P39, DOI 10.1007/978-1-4939-0897-4_3
   Gil Z, 2010, J NATL CANCER I, V102, P107, DOI 10.1093/jnci/djp456
   Grelik C, 2005, NEUROSCI LETT, V389, P140, DOI 10.1016/j.neulet.2005.07.056
   Gupta K, 2002, CANCER RES, V62, P4491
   Hanks GW, 2001, BRIT J CANCER, V84, P587, DOI 10.1054/bjoc.2001.1680
   Hao SJ, 2014, SURG LAPARO ENDO PER, V24, P31, DOI 10.1097/SLE.0000000000000032
   Hartel M, 2006, GUT, V55, P519, DOI 10.1136/gut.2005.073205
   Heim M, 2015, PAIN RES TREAT, V2015, DOI 10.1155/2015/198343
   Hemati Karim, 2015, Anesth Pain Med, V5, pe22900, DOI [10.5812/aapm.22900, 10.5812/aapm.22900]
   Jensen MP, 2009, PAIN, V146, P235, DOI 10.1016/j.pain.2009.06.027
   Juneja R, 2014, CURR OPIN SUPPORT PA, V8, P91, DOI 10.1097/SPC.0000000000000056
   Leksowski K, 2001, SURG ENDOSC, V15, P129, DOI 10.1007/s004640090009
   Lindsay TH, 2005, PAIN, V119, P233, DOI 10.1016/j.pain.2005.10.019
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Lu Y, 2007, MOL THER, V15, P1812, DOI 10.1038/sj.mt.6300228
   Mallet-Guy P., 1943, PRESSE MED, V51, P145, DOI [10.1007/s004649910017, DOI 10.1007/S004649910017]
   Masuda T, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/941726
   Mensah-Nyagan A G., 2009, Psychoneuroendocrinology, V34, pS169, DOI [DOI 10.1016/J.PSYNEUEN.2009.06.004, DOI 10.1016/j.psyneuen.2009.06.004]
   Mercadante S, 2010, CLIN J PAIN, V26, P794, DOI 10.1097/AJP.0b013e3181ecd895
   Montgomery GH, 2013, CA-CANCER J CLIN, V63, P31, DOI 10.3322/caac.21165
   Müller MW, 2008, AM J SURG, V195, P221, DOI 10.1016/j.amjsurg.2007.02.026
   Nielsen Jan Bjorn, 2008, Ugeskr Laeger, V170, P3650
   Olesen SS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057963
   Pelham A, 2002, PALLIATIVE MED, V16, P355, DOI 10.1191/0269216302pm548xx
   Penman ID, 2009, GASTROINTEST ENDOSC, V69, pS163, DOI 10.1016/j.gie.2008.12.036
   PIPER JM, 1991, ANN INTERN MED, V114, P735, DOI 10.7326/0003-4819-114-9-735
   Pour PM, 1997, AM J PATHOL, V150, P2167
   Prasad P, 2006, CARDIOVASC INTER RAD, V29, P947, DOI 10.1007/s00270-005-0184-z
   Puli SR, 2009, DIGEST DIS SCI, V54, P2330, DOI 10.1007/s10620-008-0651-x
   Rosenstock J, 2004, PAIN, V110, P628, DOI 10.1016/j.pain.2004.05.001
   Schmidt-Hansen M, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009596.pub4
   Schmulewitz N, 2003, ENDOSCOPY, V35, pS49
   Seufferlein T, 2012, ANN ONCOL, V23, P33, DOI 10.1093/annonc/mds224
   Singleton PA, 2010, FUTURE ONCOL, V6, P1237, DOI 10.2217/FON.10.99
   Sloan Paul A, 2010, J Opioid Manag, V6, P161
   Smith HS, 2008, PAIN PHYSICIAN, V11, pS89
   Staahl C, 2006, PAIN, V123, P28, DOI 10.1016/j.pain.2006.02.006
   Stacey BR, 2008, J PAIN, V9, P1006, DOI 10.1016/j.jpain.2008.05.014
   Takakuwa O, 2015, ONCOL LETT, V9, P2105, DOI 10.3892/ol.2015.3022
   Taylor AG, 2010, EXPLORE-NY, V6, P29, DOI 10.1016/j.explore.2009.10.004
   Thronæs M, 2015, CLIN THER, V37, P585, DOI 10.1016/j.clinthera.2014.12.010
   Tomulescu V, 2005, Chirurgia (Bucur), V100, P535
   Tran QN, 2006, J SUPPORT ONCOL, V4, P463
   Tran Quy N H, 2006, J Support Oncol, V4, P460
   Vranken JH, 2008, PAIN, V136, P150, DOI 10.1016/j.pain.2007.06.033
   Vyvey M, 2010, CAN FAM PHYSICIAN, V56, P1295
   Wang PJ, 2006, ABDOM IMAGING, V31, P710, DOI 10.1007/s00261-006-9153-5
   Wolfgang CL, 2013, CA-CANCER J CLIN, V63, P318, DOI 10.3322/caac.21190
   WORSEY J, 1993, BRIT J SURG, V80, P1051, DOI 10.1002/bjs.1800800842
   Yang H, 2008, MOL PAIN, V4, DOI 10.1186/1744-8069-4-8
   Yasukawa M, 2007, J ANESTH, V21, P420, DOI 10.1007/s00540-007-0528-8
NR 77
TC 41
Z9 45
U1 2
U2 24
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1948-5204
J9 WORLD J GASTRO ONCOL
JI World J. Gastrointest. Oncol.
PD AUG 15
PY 2016
VL 8
IS 8
BP 599
EP 606
DI 10.4251/wjgo.v8.i8.599
PG 8
WC Oncology; Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Gastroenterology & Hepatology
GA FE9TJ
UT WOS:000408545800003
PM 27574552
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Garland, SN
   Xie, SX
   DuHamel, K
   Bao, T
   Li, Q
   Barg, FK
   Song, S
   Kantoff, P
   Gehrman, P
   Mao, JJ
AF Garland, Sheila N.
   Xie, Sharon X.
   DuHamel, Kate
   Bao, Ting
   Li, Qing
   Barg, Frances K.
   Song, Sarah
   Kantoff, Philip
   Gehrman, Philip
   Mao, Jun J.
TI Acupuncture Versus Cognitive Behavioral Therapy for Insomnia in Cancer
   Survivors: A Randomized Clinical Trial
SO JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Article
ID SEVERITY INDEX; MANAGEMENT; VALIDATION; DISORDER; FATIGUE
AB Background: Insomnia is a common and debilitating disorder experienced by cancer survivors. Although cancer survivors express a preference for using nonpharmacological treatment to manage insomnia, the comparative effectiveness between acupuncture and Cognitive Behavioral Therapy for Insomnia (CBT-I) for this disorder is unknown.
   Methods: This randomized trial compared 8 weeks of acupuncture (n = 80) and CBT-I (n = 80) in cancer survivors. Acupuncture involved stimulating specific points on the body with needles. CBT-I included sleep restriction, stimulus control, cognitive restructuring, relaxation training, and education. We measured insomnia severity (primary outcome), pain, fatigue, mood, and quality of life posttreatment (8 weeks) with follow-up until 20 weeks. We used linear mixed-effects models for analyses. All statistical tests were two-sided.
   Results: The mean age was 61.5 years and 56.9% were women. CBT-I was more effective than acupuncture posttreatment (P<.001); however, both acupuncture and CBT-I produced clinically meaningful reductions in insomnia severity (acupuncture: -8.31 points, 95% confidence interval = -9.36 to -7.26; CBT-I: -10.91 points, 95% confidence interval = -11.97 to -9.85) and maintained improvements up to 20 weeks. Acupuncture was more effective for pain at the end of treatment; both groups had similar improvements in fatigue, mood, and quality of life and reduced prescription hypnotic medication use. CBT-I was more effective for those who were male (P<.001), white (P = .003), highly educated (P<.001), and had no pain at baseline (P<.001).
   Conclusions: Although both treatments producedmeaningful and durable improvements, CBT-I was more effective and should be the first line of therapy. The relative differences in the comparative effectiveness between the two interventions for specific groups should be confirmed in future adequately powered trials to guide more tailored interventions for insomnia.
C1 [Garland, Sheila N.] Mem Univ Newfoundland, Dept Psychol, St John, NF, Canada.
   [Garland, Sheila N.] Mem Univ Newfoundland, Dept Oncol, St John, NF, Canada.
   [Xie, Sharon X.] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA.
   [DuHamel, Kate] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, 1275 York Ave, New York, NY 10021 USA.
   [Bao, Ting; Li, Qing; Kantoff, Philip; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
   [Barg, Frances K.; Song, Sarah] Penn Presbyterian Med Ctr, Dept Family Med & Community Hlth, Andrew Mutch Bldg, Philadelphia, PA USA.
   [Gehrman, Philip] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
C3 Memorial University Newfoundland; Memorial University Newfoundland;
   University of Pennsylvania; Memorial Sloan Kettering Cancer Center;
   Memorial Sloan Kettering Cancer Center; University of Pennsylvania;
   Pennsylvania Medicine; Pennsylvania Presbyterian Medical Center;
   University of Pennsylvania
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
EM maoj@mskcc.org
RI ; Garland, Sheila/AGL-7759-2022; Barg, Frances/E-1703-2017; Xie,
   Sharon/JCO-7144-2023
OI Song, Sarah/0000-0002-3341-8468; Garland, Sheila/0000-0002-6119-318X;
   Mao, Jun/0000-0001-9229-0380; 
FU Patient-Centered Outcomes Research Institute (PCORI) award
   [CER-1403-14292]; National Institutes of Health/National Cancer
   Institute Cancer Center grant [P30 CA008748]; National Cancer Institute
   [P30CA008748] Funding Source: NIH RePORTER
FX This work was supported by a Patient-Centered Outcomes Research
   Institute (PCORI) award (grant number CER-1403-14292). This work was
   also supported in part by a National Institutes of Health/National
   Cancer Institute Cancer Center grant (number P30 CA008748).
CR Berger AM, 2017, ONCOLOGY-NY, V31, P610
   Bjelland I, 2002, J PSYCHOSOM RES, V52, P69, DOI 10.1016/S0022-3999(01)00296-3
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1002/smll.202408771
   Carney CE, 2012, SLEEP, V35, P287, DOI 10.5665/sleep.1642
   Choi TY, 2017, INTEGR CANCER THER, V16, P135, DOI 10.1177/1534735416664172
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Fleming L, 2015, CURR SLEEP MED REP, V1, P177, DOI [10.1007/s40675-015-0021-0, 10.1007/s40675-015-0021-0, DOI 10.1007/S40675-015-0021-0]
   Fu C, 2017, SLEEP, P40
   Garland SN, 2018, SUPPORT CARE CANCER, V26, P2407, DOI 10.1007/s00520-018-4086-4
   Garland SN, 2016, CONTEMP CLIN TRIALS, V47, P349, DOI 10.1016/j.cct.2016.02.010
   Garland SN, 2014, J CLIN ONCOL, V32, P449, DOI 10.1200/JCO.2012.47.7265
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   Hays RD, 2009, QUAL LIFE RES, V18, P873, DOI 10.1007/s11136-009-9496-9
   Johnson JA, 2016, SLEEP MED REV, V27, P20, DOI 10.1016/j.smrv.2015.07.001
   Kripke Daniel F, 2016, F1000Res, V5, P918, DOI 10.12688/f1000research.8729.1
   MacLeod Jodi, 2017, Journal of the National Cancer Institute Monographs, P46, DOI [10.1093/jncimonographs/lgx008, 10.1093/jncimonographs/lgx008]
   Manni L, 2010, AUTON NEUROSCI-BASIC, V157, P9, DOI 10.1016/j.autneu.2010.03.020
   Mao Jun J, 2007, Acupunct Med, V25, P158
   Mao JJ, 2010, ALTERN THER HEALTH M, V16, P22
   Matthews EE, 2012, BEHAV SLEEP MED, V10, P217, DOI 10.1080/15402002.2012.666220
   McCarthy MS, 2018, ONCOL NURS FORUM, V45, P607, DOI 10.1188/18.ONF.607-618
   Medalie L, 2017, JAMA-J AM MED ASSOC, V317, P762, DOI 10.1001/jama.2016.19004
   Morin CM, 2011, SLEEP, V34, P601, DOI 10.1093/sleep/34.5.601
   Qaseem A, 2016, ANN INTERN MED, V165, P125, DOI 10.7326/M15-2175
   Savard J, 2011, J CLIN ONCOL, V29, P3580, DOI 10.1200/JCO.2010.33.2247
   Savard MH, 2005, PSYCHO-ONCOLOGY, V14, P429, DOI 10.1002/pon.860
   Schutte-Rodin S, 2008, J CLIN SLEEP MED, V4, P487
   Sedgwick P, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g6694
   Soligo M, 2013, INT REV NEUROBIOL, V111, P91, DOI 10.1016/B978-0-12-411545-3.00005-5
   Stein KD, 2004, J PAIN SYMPTOM MANAG, V27, P14, DOI 10.1016/j.jpainsymman.2003.06.003
   Stepanski EJ, 2009, J CLIN SLEEP MED, V5, P132
   Yin X, 2017, SLEEP MED, V37, P193, DOI 10.1016/j.sleep.2017.02.012
   Yun Hyeongjun, 2017, Journal of the National Cancer Institute Monographs, P29, DOI [10.1093/jncimonographs/lgx004, 10.1093/jncimonographs/lgx004]
   Zachariae R, 2018, JNCI-J NATL CANCER I, V110, P880, DOI 10.1093/jnci/djx293
   Zhou ES, 2017, J CANCER SURVIV, V11, P74, DOI 10.1007/s11764-016-0564-1
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 36
TC 128
Z9 154
U1 1
U2 65
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0027-8874
EI 1460-2105
J9 JNCI-J NATL CANCER I
JI JNCI-J. Natl. Cancer Inst.
PD DEC
PY 2019
VL 111
IS 12
BP 1323
EP 1331
AR djz050
DI 10.1093/jnci/djz050
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology
GA KF9HG
UT WOS:000509549100010
PM 31081899
OA Bronze
DA 2026-01-16
ER

PT J
AU Znidarsic, J
   Kirksey, KN
   Dombrowski, SM
   Tang, AN
   Lopez, R
   Blonsky, H
   Todorov, I
   Schneeberger, D
   Doyle, J
   Libertini, L
   Jamie, S
   Segall, T
   Bang, A
   Barringer, K
   Judi, B
   Ehrman, JP
   Roizen, MF
   Golubic, M
AF Znidarsic, Josie
   Kirksey, Kellie N.
   Dombrowski, Stephen M.
   Tang, Anne
   Lopez, Rocio
   Blonsky, Heather
   Todorov, Irina
   Schneeberger, Dana
   Doyle, Jonathan
   Libertini, Linda
   Jamie, Starkey
   Segall, Tracy
   Bang, Andrew
   Barringer, Kathy
   Judi, Bar
   Ehrman, Jane Pernotto
   Roizen, Michael F.
   Golubic, Mladen
CA CYTERYT 500
TI "Living Well with Chronic Pain": Integrative Pain Management via Shared
   Medical Appointments
SO PAIN MEDICINE
LA English
DT Article
DE Chronic Pain; Opioids; Pain Management
ID ADULTS
AB Objective. To evaluate the effectiveness of a multidisciplinary, nonpharmacological, integrative approach that uses shared medical appointments to improve health-related quality of life and reduce opioid medication use in patients with chronic pain. Design. This is a retrospective, pre-post review of "Living Well with Chronic Pain" shared medical appointments (August 2016 through May 2018). Setting. The appointments included eight 3-hour-long visits held once per week at an outpatient wellness facility. Subjects. Patients with chronic, non-cancer-related pain. Methods. Patients received evaluation and evidence-based therapies from a team of integrative and lifestyle medicine professionals, as well as education about nonpharmacological therapeutic approaches, the etiology of pain, and the relationship of pain to lifestyle factors. Experiential elements focused on the relaxation techniques of meditation, yoga, breathing, and hypnotherapy, while patients also received acupuncture, acupressure, massage, cognitive behavioral therapy, and chiropractic education. Patients self-reported data via the Patient-Reported Outcomes Measurement Information System (PROMIS-57) standardized questionnaire. Use of opioid medications was evaluated in morphine milligram equivalents. Results. A total of 178 participants completed the PROMIS-57 questionnaire at the first and the last visits. Statistically significant improvements in all domains (Physical Functioning, Anxiety, Depression, Fatigue, Social Roles, Pain Interference, and Sleep Disturbance) were observed (P<0.001) between the pre-intervention (visit 1) and post-intervention (visit 8) scores. Average opioid use decreased nonsignificantly over the 8-week intervention, but the lower rate of opioid use was not sustained at 6 and 12 months' follow-up. Conclusions. Patients suffering from chronic pain who participated in a multidisciplinary, nonpharmacological treatment approach delivered via shared medical appointments experienced reduced pain and improved measures of physical, mental, and social health without increased use of opioid pain medications.
C1 [Znidarsic, Josie; Kirksey, Kellie N.; Dombrowski, Stephen M.; Tang, Anne; Lopez, Rocio; Blonsky, Heather; Todorov, Irina; Schneeberger, Dana; Doyle, Jonathan; Libertini, Linda; Jamie, Starkey; Segall, Tracy; Bang, Andrew; Barringer, Kathy; Judi, Bar; Ehrman, Jane Pernotto; Roizen, Michael F.; Golubic, Mladen] Cleveland Clin, Ctr Integrat & Lifestyle Med, 1950 Richmond Rd,TR2-341, Lyndhurst, OH 44124 USA.
C3 Cleveland Clinic Foundation
RP Golubic, M (corresponding author), Cleveland Clin, Ctr Integrat & Lifestyle Med, 1950 Richmond Rd,TR2-341, Lyndhurst, OH 44124 USA.
EM golubim@ccf.org
RI López-Flores, Rocío/F-6813-2011
OI Lopez Moscoso, Ana Rocio/0000-0002-4319-420X; Segall,
   Tracy/0000-0001-5605-7186; Dombrowski, Stephen/0000-0002-1081-824X
FU Center for Integrative and Lifestyle Medicine, Cleveland Clinic
   Community Care; Center for Population Health Research, Department of
   Quantitative Health Sciences, Cleveland Clinic
FX This study was supported through internal institutional funds from the
   Center for Integrative and Lifestyle Medicine, Cleveland Clinic
   Community Care, and the Center for Population Health Research,
   Department of Quantitative Health Sciences, Cleveland Clinic..
CR Bernstein DN, 2019, SPINE, V44, pE852, DOI 10.1097/BRS.0000000000002979
   Bernstein DN, 2019, FOOT ANKLE INT, V40, P139, DOI 10.1177/1071100718803314
   Chao MT, 2015, PAIN MANAG NURS, V16, P920, DOI 10.1016/j.pmn.2015.07.007
   Chen CX, 2018, PAIN, V159, P775, DOI 10.1097/j.pain.0000000000001121
   Chou R, 2017, ANN INTERN MED, V166, P493, DOI 10.7326/M16-2459
   Colloca L, 2020, NEW ENGL J MED, V382, P554, DOI 10.1056/NEJMra1907805
   Coulter ID, 2018, SPINE J, V18, P866, DOI 10.1016/j.spinee.2018.01.013
   Dahlhamer J, 2018, MMWR-MORBID MORTAL W, V67, P1001, DOI 10.15585/mmwr.mm6736a2
   Ersek M, 2003, CLIN J PAIN, V19, P156, DOI 10.1097/00002508-200305000-00003
   Franovic Sreten, 2019, JB JS Open Access, V4, pe0019, DOI [10.2106/jbjs.oa.19.00019, 10.2106/JBJS.OA.19.00019]
   Gardiner P, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0225540
   Gardiner Paula, 2014, Glob Adv Health Med, V3, P20, DOI 10.7453/gahmj.2014.011
   Garland EL, 2020, JAMA INTERN MED, V180, P91, DOI 10.1001/jamainternmed.2019.4917
   Geller Jeffrey S, 2015, Glob Adv Health Med, V4, P27, DOI [10.7453/gahmj.2015.057, 10.7453/gahmj.2015.057]
   Gomes T, 2018, JAMA NETW OPEN, V1, DOI 10.1001/jamanetworkopen.2018.0217
   Hassan S, 2020, PAIN MED, V21, P836, DOI 10.1093/pm/pnz291
   HealthMeasures, MEAN CHANG PROMIS VR
   Kazmers NH, 2020, J HAND SURG-AM, V45, P399, DOI 10.1016/j.jhsa.2019.12.002
   Kendall R, 2018, PAIN MED, V19, P1720, DOI 10.1093/pm/pnx310
   Khalifeh JM, 2019, J NEUROSURG-SPINE, V31, P165, DOI 10.3171/2019.2.SPINE181237
   Kortlever JTP, 2015, CLIN ORTHOP RELAT R, V473, P3511, DOI 10.1007/s11999-015-4419-2
   Kroenke K, 2019, MED CARE, V57, P890, DOI 10.1097/MLR.0000000000001185
   Law T, 2019, HOLIST NURS PRACT, V33, P354, DOI 10.1097/HNP.0000000000000353
   Li LW, 2018, ARTHRIT CARE RES, V70, P221, DOI 10.1002/acr.23262
   Marchant J, 2016, NATURE, V535, pS14, DOI 10.1038/535S14a
   McCormack S, 2019, BOOKSHELF ID NBK5460
   Mehl-Madrona L, 2016, J ALTERN COMPLEM MED, V22, P621, DOI 10.1089/acm.2015.0212
   Nicholas MK, 2020, PAIN, V161, P509, DOI 10.1097/j.pain.0000000000001763
   Nielsen A, 2019, EXPLORE-NY, V15, P434, DOI 10.1016/j.explore.2019.08.009
   Preuss C.V., 2020, STATPEARLS
   Qaseem A, 2017, ANN INTERN MED, V166, P514, DOI 10.7326/M16-2367
   Romanelli Robert J, 2017, J Patient Exp, V4, P144, DOI [10.1177/2374373517706837, 10.1177/2374373517706837]
   Schneeberger D, 2019, J ALTERN COMPLEM MED, V25, P40, DOI 10.1089/acm.2018.0154
   Shibuya K, 2018, CLEV CLIN J MED, V85, P699, DOI 10.3949/ccjm.85a.18006
   Soelberg CD, 2017, ANESTH ANALG, V125, P1675, DOI 10.1213/ANE.0000000000002403
   Srivastava G, 2018, FRONT PEDIATR, V6, DOI 10.3389/fped.2018.00101
   Suso-Ribera C, 2017, PAIN RES MANAG, V2017, DOI 10.1155/2017/9762864
   The Joint Commission Division of Healthcare Improvement, 2018, QUICK SAFETY
   Vaughan EM, 2019, CURR DIABETES REV, V15, P372, DOI 10.2174/1573399814666181112145910
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
NR 40
TC 18
Z9 22
U1 1
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD JAN
PY 2021
VL 22
IS 1
BP 181
EP 190
DI 10.1093/pm/pnaa418
EA FEB 2021
PG 10
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; General & Internal Medicine
GA SA5NC
UT WOS:000649349100020
PM 33543263
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Wang, CJ
   Tan, W
   Huang, XH
   Fu, TT
   Lin, JZ
   Bu, JM
   Wei, GJ
   Du, Y
AF Wang, Changjun
   Tan, Wei
   Huang, Xuhui
   Fu, Tingting
   Lin, Juze
   Bu, Junmin
   Wei, Guojian
   Du, Yu
TI Curative effect of Dingqi analgesic patch on cancer pain: a single-blind
   randomized controlled trail
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE Analgesics; Liver neoplasms; Pain; Acupuncture points; Randomized
   controlled trail
ID SCALES; LADDER
AB OBJECTIVE: To observe the curative effect of an acupoint application with a Dingqi analgesic patch on moderate to severe pain caused by liver cancer.
   METHODS: Forty patients with moderate to severe pain caused by liver cancer were randomly divided into a treatment group (TG) and a control group (CG). Patients with moderate pain were given 100 mg qd of a sustainably released tablet of tramadol hydrochloride; patients with-severe pain were given 4.2 mg q3d of the fentanyl transdermal system. The ashi points Ganshu (BL 18), Danshu (BL 19) and Qimen (LR 14) were chosen for the acupoint application intervention. CG patients were given a sham patch and TG patients were given a Dingqi analgesic patch. A visual analogue scale (VAS) was used before treatment and after 1, 3, 6, 9 and 12 days of treatment. The Karnofsky score was measured before treatment and after 12 days of treatment. Any main adverse reactions (e.g. nausea, constipation, dizziness and headache) were recorded after 6 and 12 days of treatment. Any skin side effects (i.e. skin irritation and allergic reactions) were recorded.
   RESULTS: The VAS in TG was significantly lower than that in CG after 3, 6, 9 and 12 days of treatment (P<0.05). There was no significant difference in the Karnofsky score before treatment and after 12 days of treatment between CG and TG. There were also no significant differences in the main adverse reactions or skin side effects after 6 and 12 days of treatment between CG and TG (P>0.05).
   CONCLUSION: The Dingqi analgesic patch can enhance the analgesic effect of tramadol and fentanyl. (C) 2013 JTCM. All rights reserved.
C1 [Wang, Changjun; Tan, Wei; Huang, Xuhui; Fu, Tingting; Lin, Juze; Bu, Junmin; Wei, Guojian; Du, Yu] Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangdong Geriatr Inst, Dept Tradit Chinese Med, Guangzhou 510080, Guangdong, Peoples R China.
C3 Southern Medical University - China; Guangdong Academy of Medical
   Sciences & Guangdong General Hospital
RP Wang, CJ (corresponding author), Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangdong Geriatr Inst, Dept Tradit Chinese Med, Guangzhou 510080, Guangdong, Peoples R China.
EM gzwchj@126.com
RI Wang, Changjun/AAY-1571-2021
FU Administration of Traditional Chinese Medicine of Guangdong Province,
   China [2010431]
FX Supported by the Administration of Traditional Chinese Medicine of
   Guangdong Province, China (No. 2010431)
CR Ai F., 2010, ZHONGCAOYAO, V41, P201
   AITKEN RCB, 1969, P ROY SOC MED, V62, P989, DOI 10.1177/003591576906201005
   [Anonymous], 2009, MED LETT DRUGS THER, V51, P29
   Chang YunPing Chang YunPing, 2012, Drugs and Clinic, V27, P52
   Chen S, 2012, GUANG MING ZHONG YI, V27, P1841
   Chinese Medical Association, 2005, GUID CLIN PRACT CANC, P322
   Csupor D, 2011, PHARM BIOL, V49, P1097, DOI 10.3109/13880209.2011.595011
   Forbes K, 2011, CLIN ONCOL-UK, V23, P379, DOI 10.1016/j.clon.2011.04.016
   Fu Ying Fu Ying, 2011, Zhongcaoyao = Chinese Traditional and Herbal Drugs, V42, P1229
   Ge Hong-Yan, 2012, Zhongguo Zhen Jiu, V32, P602
   Han Zhifeng, 2011, Zhongguo Zhong Yao Za Zhi, V36, P41
   Han ZY, 2007, ZHONG YI YAO GUAN LI, V15, P142
   Huang CF, 2011, AM J CHINESE MED, V39, P981, DOI 10.1142/S0192415X11009354
   Huang QF, 2011, ZHEN JIU TUI NA YI X, V9, P346
   Li XL, 2006, XIN ZHONG YI, V38, P71
   Liu YQ, 2011, ZHONG GUO TENG TONG, V17, P314
   Mo YF, 2011, HUNAN ZHONG YI YAO D, V31, P40
   Mo YF, 2008, ZHONG GUO MIN ZU MIN, P25
   Peng Jin, 2012, Zhong Xi Yi Jie He Xue Bao, V10, P39
   Phillips DM, 2000, JAMA-J AM MED ASSOC, V284, P428, DOI 10.1001/jama.284.4.428
   Pu ZY, 2005, JI LIN ZHONG YI YAO, V25, P21
   Qin YY, 2011, GUANG MING ZHONG YI, V26, P1121
   Qiu YB, 2011, ZHONG GUO LIAO YANG, V20, P435
   Ripamonti CI, 2009, CLIN J PAIN, V25, P386, DOI 10.1097/AJP.0b013e3181929b4f
   Shao YZ, 2010, LIAONING ZHONG YI ZA, V37, P352
   Sun H, 2008, HUBEI ZHONG YI ZA ZH, V30, P32
   Sun LH, 2002, JIANGXI ZHONG YI XUE, V14, P19
   Swarm R, 2010, J NATL COMPR CANC NE, V8, P1046, DOI 10.6004/jnccn.2010.0076
   Tang WJ, 2012, SHI YONG ZHONG XI YI, V12, P23
   Tassinari D, 2011, PALLIATIVE MED, V25, P410, DOI 10.1177/0269216311405090
   Wang SH, 2011, ZHONG YI ZA ZHI, V52, P962
   Wang XP, 2010, SHANGHAI ZHEN JIU ZA, V29, P506
   Williamson A, 2005, J CLIN NURS, V14, P798, DOI 10.1111/j.1365-2702.2005.01121.x
   Xie Hong-Liang, 2010, Zhongguo Zhen Jiu, V30, P567
   Yang YZ, 2011, LIAONING ZHONG YI ZA, V38, P1192
   Yuan J, 2009, ZHONG YAO CAI, V32, P1442
   Zeng JG, 2011, ZHONG GUO YAO WU JIN, P82
   Zhang SH, 2003, ZHONG YI ZA ZHI, V44, P648
   Zhang YM, 2009, XI BEI YAO XUE ZA ZH, V24, P399
   Zhao JF, 2011, ZHONG GUO YAO FANG, V22, P661
NR 40
TC 4
Z9 7
U1 1
U2 13
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD APR 15
PY 2013
VL 33
IS 2
BP 176
EP 180
DI 10.1016/S0254-6272(13)60121-1
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 124CI
UT WOS:000317441000005
PM 23789213
OA hybrid
DA 2026-01-16
ER

PT J
AU Dilaveri, CA
   Croghan, IT
   Mallory, MJ
   Dion, LJ
   Fischer, KM
   Schroeder, DR
   Martinez-Jorge, J
   Nguyen, MDT
   Fokken, SC
   Bauer, BA
   Wahner-Roedler, DL
AF Dilaveri, Christina A.
   Croghan, Ivana T.
   Mallory, Molly J.
   Dion, Liza J.
   Fischer, Karen M.
   Schroeder, Darrell R.
   Martinez-Jorge, Jorys
   Nguyen, Minh-Doan T.
   Fokken, Shawn C.
   Bauer, Brent A.
   Wahner-Roedler, Dietlind L.
TI Massage Compared with Massage Plus Acupuncture for Breast Cancer
   Patients Undergoing Reconstructive Surgery
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE acupuncture; integrative therapy; massage; stress
ID THERAPY; SELECTION; IMPACT; BIAS; CARE; PAIN
AB Objectives:Integrative therapies have been incorporated increasingly into health and wellness in the United States in recent decades. Their potential benefits are under evaluation in various situations, including pain and symptom relief for cancer patients and survivors. This pilot study evaluated whether combining two integrative complementary approaches augments a patient's benefit by reducing postoperative stress, pain, anxiety, muscle tension, and fatigue compared with one integrative complementary approach alone. Design:Patients undergoing autologous tissue breast reconstruction were randomly assigned to one of two postoperative complementary alternative therapies for three consecutive days. All participants were observed for up to 3 months. Subjects:Forty-two participants were recruited from January 29, 2016 to July 11, 2018. Interventions:Twenty-one participants were randomly assigned to massage alone and 21 to massage and acupuncture. Outcome measures:Stress, anxiety, relaxation, nausea, fatigue, pain, and mood (score 0-10) were measured at enrollment before surgery and postoperative days 1, 2, and 3 before and after the intervention. Patient satisfaction was evaluated. Results:Stress decreased from baseline for both Massage-Only Group and Massage+Acupuncture Group after each treatment intervention. Change in stress score from baseline decreased significantly more in the Massage-Only Group at pretreatment and posttreatment (p = 0.03 andp = 0.04). After adjustment for baseline values, change in fatigue, anxiety, relaxation, nausea, pain, and mood scores did not differ between groups. When patients were asked whether they would recommend the study, 100% (19/19) of Massage-Only Group and 94% (17/18) of Massage+Acupuncture Group responded yes (p = 0.49). Conclusion:No additive beneficial effects were observed with addition of acupuncture to massage for pain, anxiety, relaxation, nausea, fatigue, and mood. Combined massage and acupuncture was not as effective in reducing stress as massage alone, although both groups had significant stress reduction. These findings indicate a need for larger studies to explore these therapies further.
C1 [Dilaveri, Christina A.; Croghan, Ivana T.; Mallory, Molly J.; Dion, Liza J.; Fokken, Shawn C.; Bauer, Brent A.; Wahner-Roedler, Dietlind L.] Mayo Clin, Div Gen Internal Med, 200 First St SW, Rochester, MN 55905 USA.
   [Croghan, Ivana T.; Fischer, Karen M.; Schroeder, Darrell R.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA.
   [Croghan, Ivana T.; Fokken, Shawn C.] Mayo Clin, Dept Med Clin Res Off, Rochester, MN 55905 USA.
   [Martinez-Jorge, Jorys; Nguyen, Minh-Doan T.] Mayo Clin, Div Plast & Reconstruct Surg, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Croghan, IT (corresponding author), Mayo Clin, Div Gen Internal Med, 200 First St SW, Rochester, MN 55905 USA.
EM croghan.ivana@mayo.edu
RI Mallory, Molly/AAF-7370-2021
CR An LX, 2014, AM J CHINESE MED, V42, P1099, DOI 10.1142/S0192415X14500682
   [Anonymous], 2020, US BREAST CANC STAT
   [Anonymous], CONSORT FLOW DIAGR
   [Anonymous], 2018, Complementary, Alternative, or Integrative Health: What's In a Name?
   Bu Ling-xue, 2011, Shanghai Kou Qiang Yi Xue, V20, P292
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   Cutshall Susanne M, 2010, Complement Ther Clin Pract, V16, P92, DOI 10.1016/j.ctcp.2009.10.006
   Dion LJ, 2016, COMPLEMENT THER CLIN, V23, P82, DOI 10.1016/j.ctcp.2015.04.005
   Drackley NL, 2012, CLIN J ONCOL NURS, V16, P121, DOI 10.1188/12.CJON.121-124
   DUNN C, 1995, J ADV NURS, V21, P34, DOI 10.1046/j.1365-2648.1995.21010034.x
   Field T, 2016, COMPLEMENT THER CLIN, V24, P19, DOI 10.1016/j.ctcp.2016.04.005
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Halpern SD, 2003, J CLIN EPIDEMIOL, V56, P109, DOI 10.1016/S0895-4356(02)00598-X
   Haneuse S, 2016, MED CARE, V54, pE23, DOI 10.1097/MLR.0000000000000011
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Hayes J, 1999, Intensive Crit Care Nurs, V15, P77, DOI 10.1016/S0964-3397(99)80003-2
   Jeong YJ, 2015, MED ACUPUNCT, V27, P206, DOI 10.1089/acu.2014.1071
   Jüni P, 2001, BMJ-BRIT MED J, V323, P42, DOI 10.1136/bmj.323.7303.42
   Kinkead B, 2018, CANCER-AM CANCER SOC, V124, P546, DOI 10.1002/cncr.31064
   Lee PLT, 2016, COMPLEMENT THER MED, V27, P87, DOI 10.1016/j.ctim.2016.06.003
   Lewis P, 1997, Am J Crit Care, V6, P132
   Mallory MJ, 2015, AM J CHINESE MED, V43, P45, DOI 10.1142/S0192415X15500032
   Mazor KM, 2002, HEALTH SERV RES, V37, P1403, DOI 10.1111/1475-6773.11194
   MCCORKLE R, 1974, NURS RES, V23, P125
   Mehling WE, 2007, J PAIN SYMPTOM MANAG, V33, P258, DOI 10.1016/j.jpainsymman.2006.09.016
   Quinlan-Woodward J, 2016, ONCOL NURS FORUM, V43, P725, DOI 10.1188/16.ONF.725-732
   RUCKER G, 1989, STAT MED, V8, P477, DOI 10.1002/sim.4780080411
   SAS Institute Inc, 2020, SAS STAT
   Schroeder S, 2017, J ACUPUNCT MERIDIAN, V10, P165, DOI 10.1016/j.jams.2017.01.002
   Smith MC, 1999, ALTERN THER HEALTH M, V5, P64
   TYLER DO, 1990, HEART LUNG, V19, P562
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Wentworth Laura J, 2009, Prog Cardiovasc Nurs, V24, P155, DOI 10.1111/j.1751-7117.2009.00054.x
   Yuan W, 2019, CHINESE MED J-PEKING, V132, P707, DOI 10.1097/CM9.0000000000000123
NR 34
TC 13
Z9 16
U1 1
U2 20
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD JUL 1
PY 2020
VL 26
IS 7
BP 602
EP 609
DI 10.1089/acm.2019.0479
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA MK5FJ
UT WOS:000548812300006
PM 32673082
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Kim, HS
   Park, IH
   Seo, SH
   Han, I
   Cho, HS
AF Kim, Han-Soo
   Park, Il Hyung
   Seo, Sung Hwa
   Han, Ilkyu
   Cho, Hwan Seong
TI Multifocal Infection of Mycobacterium Other Than Tuberculosis
   Mimicking a Soft Tissue Tumor of the Extremity
SO ORTHOPEDICS
LA English
DT Article
AB Mycobacterium other than tuberculosis infections rarely develop in healthy individuals, but direct inoculation such as contaminated acupuncture can cause mycobacteriosis even in an immunocompetent host. A 56-year-old woman gradually developed pain on the anterior aspect of the left knee and the distal thigh after hiking without trauma. She received acupuncture for 3 consecutive days on the bilateral knees at the suprapatellar and infrapopliteal areas. After acupuncture, mild localized heat and painful swelling developed around the knees bilaterally. Magnetic resonance imaging (MRI) demonstrated soft tissue masses with a lobulated contour at the prefemoral fat between the suprapatellar pouch and the distal femur and at the proximal tibia behind the knee joint capsule. Fibromatosis, pigmented villonodular synovitis, and soft tissue sarcoma were considered. On pathologic examination, multiple granulomas with lymphoplasmatic infiltration were evident, and acid-fast bacteria staining revealed acid-fast bacilli. A mycobacterial culture confirmed Mycobacterium other than tuberculosis infection, and a polymerase chain reaction-fragment length polymorphism assay identified the isolates as Mycobacterium abscessus. After treatment with appropriate antibiotics, the patient had no evidence of disease and reported no pain during activities of daily living.
   Acupuncture is growing in prominence in Europe and the United States, and the number of reports on complications increases with its widespread use. Although the risk to an individual patient is difficult to determine, acupuncture may cause serious complications in patients with coagulopathy, heart valve disease, and immune deficiency. In addition, direct inoculation such as contaminated acupuncture can cause mycobacteriosis even in an immunocompetent host.
C1 [Kim, Han-Soo; Han, Ilkyu; Cho, Hwan Seong] Seoul Natl Univ, Coll Med, Dept Orthoped Surgety, Seoul, South Korea.
   [Park, Il Hyung] Kyungpook Natl Univ, Sch Med, Dept Orthoped Surgery, Taegu, South Korea.
   [Seo, Sung Hwa] Kyungpook Natl Univ, Dept Biomed Sci, Taegu, South Korea.
C3 Seoul National University (SNU); Kyungpook National University (KNU);
   Kyungpook National University (KNU)
RP Cho, HS (corresponding author), Seoul Natl Univ, Bundang Hosp, Dept Orthoped Surg, 166 Gumi Ro Bundang Gu, Songnam 463707, Gyeonggi Do, South Korea.
EM mdchs111@snu.ac.kr
RI HAN, ILKYU/D-9645-2012; Kim, Hansoo/D-5743-2012
OI HAN, ILKYU/0000-0001-9841-3775; 
NR 0
TC 5
Z9 7
U1 0
U2 3
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
J9 ORTHOPEDICS
JI Orthopedics
PD DEC
PY 2011
VL 34
IS 12
BP 1007
EP 1007
DI 10.3928/01477447-20111021-31
PG 1
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 864AJ
UT WOS:000298209100040
DA 2026-01-16
ER

PT J
AU Lim, JTW
   Wong, ET
   Aung, SKH
AF Lim, Jan T. W.
   Wong, Erin T.
   Aung, Steven K. H.
TI Is there a role for acupuncture in the symptom management of patients
   receiving palliative care for cancer? A pilot study of 20 patients
   comparing acupuncture with nurse-led supportive care
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
ID SHAM ACUPUNCTURE; CONTROLLED-TRIAL; PAIN; VALIDATION; INTERVENTIONS;
   ONCOLOGY; PLACEBO; REAL
AB Purpose A pilot study to document changes in symptoms after acupuncture or nurse-led supportive care in patients with incurable cancer.
   Methods Patients receiving palliative care with estimated survival of at least 3 months were screened with the Edmonton Symptom Assessment System (ESAS). Patients (n = 20) with significant symptoms were randomised to receive weekly acupuncture or nurse-led supportive care for 4 weeks. ESAS scores were obtained before and after each treatment, and weekly for 6 weeks after treatment by telephone.
   Results 42 of 170 patients screened were eligible. 20 gave consent for recruitment. The compliance rate was 90% for acupuncture and 80% for nurse-led supportive care. Total symptom scores were reduced by an average of 22% after each acupuncture visit and by 14% after each supportive care visit. Compared with baseline, ESAS scores at the end of the follow-up period were reduced by 19% for the acupuncture arm and 26% for nurse-led supportive care.
   Conclusion Patients appear to benefit from incorporating acupuncture in the treatment of advanced incurable cancer. Acupuncture was well tolerated with no significant or unexpected side effects. Acupuncture had an immediate effect on all symptoms, whereas nurse-led supportive care had a larger impact 6 weeks after the final session. Both interventions appear helpful to this population and warrant further study.
C1 [Lim, Jan T. W.] Univ British Columbia, Dept Surg, Div Radiat Oncol, Vancouver, BC V6T 1W5, Canada.
   [Wong, Erin T.] Univ Toronto, Fac Med, Toronto, ON, Canada.
   [Aung, Steven K. H.] Univ Alberta, Fac Med & Dent, Edmonton, AB, Canada.
C3 University of British Columbia; University of Toronto; University of
   Alberta
RP Lim, JTW (corresponding author), 2410 Lee Ave, Victoria, BC V8R 6V5, Canada.
EM jlim@bccancer.bc.ca
FU Canadian Institute for Health Research New Emerging Team; British
   Columbia Cancer Foundation Vancouver Island Research and Development
   Catalyst
FX Funding for this study was supplied from the Canadian Institute for
   Health Research New Emerging Team Grant 'Overcoming the barriers to
   communication in Palliative/EOL Care'. The study also received support
   from a British Columbia Cancer Foundation Vancouver Island Research and
   Development Catalyst Grant. These funding sources had no involvement in
   study design, the collection, analysis and interpretation of data, the
   writing of the report, or in the decision to submit the paper for
   publication.
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Assefi NP, 2005, ANN INTERN MED, V143, P10, DOI 10.7326/0003-4819-143-1-200507050-00005
   AUNG SKH, 2007, CLIN INTRO MED ACUPU, P24
   Cohen Andrea J, 2005, Integr Cancer Ther, V4, P131, DOI 10.1177/1534735405276419
   Deng G, 2005, CA-CANCER J CLIN, V55, P109, DOI 10.3322/canjclin.55.2.109
   Downs NM, 2005, ARCH PHYS MED REHAB, V86, P1252, DOI 10.1016/j.apmr.2004.10.037
   Filshie Jacqueline, 2006, Acupunct Med, V24, P172
   Goddard G, 2005, J PAIN, V6, P237, DOI 10.1016/j.jpain.2004.12.009
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   Johnstone PAS, 2002, PALLIATIVE MED, V16, P235, DOI 10.1191/0269216302pm540oa
   Kaptchuk TJ, 2002, ANN INTERN MED, V136, P374, DOI 10.7326/0003-4819-136-5-200203050-00010
   Kreiner M, 2010, ACUPUNCT MED, V28, P33, DOI 10.1136/aim.2009.001735
   Lundeberg T, 2008, ACUPUNCT MED, V26, P239, DOI 10.1136/aim.26.4.239
   Mayer DJ, 2000, ANNU REV MED, V51, P49, DOI 10.1146/annurev.med.51.1.49
   Molsberger AF, 2004, EUR J MED RES, V9, P405
   Nekolaichuk C, 2008, PALLIATIVE MED, V22, P111, DOI 10.1177/0269216307087659
   Nystrom E, 2008, ACUPUNCT MED, V26, P27, DOI 10.1136/aim.26.1.27
   Sagar SM, 2005, CURR ONCOL, V12, P103
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   SOLA I, 2004, COCHRANE DB SYST REV, V4
   Takakura N, 2010, ACUPUNCT MED, V28, P144, DOI 10.1136/aim.2009.001230
   Uitterhoeve RJ, 2004, BRIT J CANCER, V91, P1050, DOI 10.1038/sj.bjc.6602103
   Vickers AJ, 2004, J CLIN ONCOL, V22, P1731, DOI 10.1200/JCO.2004.04.102
   Wong Raimond, 2006, Acupunct Med, V24, P87
   Zeng LA, 2011, J PALLIAT MED, V14, P337, DOI 10.1089/jpm.2010.0438
NR 25
TC 19
Z9 23
U1 0
U2 7
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD SEP
PY 2011
VL 29
IS 3
BP 173
EP 179
DI 10.1136/aim.2011.004044
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 812XL
UT WOS:000294326700004
PM 21666275
DA 2026-01-16
ER

PT J
AU Street, RL
AF Street, Richard L., Jr.
TI How clinician-patient communication contributes to health improvement:
   Modeling pathways from talk to outcome
SO PATIENT EDUCATION AND COUNSELING
LA English
DT Article; Proceedings Paper
CT International Conference on Communication in Healthcare (ICCH)
CY 2012
CL Univ St Andrews, Med Sch, St Andrews, SCOTLAND
SP European Assoc Commun Healthcare
HO Univ St Andrews, Med Sch
DE Physician-patient communication; Health outcomes; Communication
   measurement; Communication pathways
ID RANDOMIZED CONTROLLED-TRIAL; SHARED DECISION-MAKING; CENTERED
   COMMUNICATION; CARE; CANCER; CONSULTATIONS; IMPACT; INTERVENTION;
   ACUPUNCTURE; DELIVERY
AB Objective: Although researchers have long investigated relationships between clinician-patient communication and health outcomes, much of the research has produced null, inconsistent, or contradictory findings. This essay examines challenges in the study of how clinician-patient communication contributes to a patient's health and offers recommendations for future research.
   Discussion: Communication may directly impact outcomes, but more often it will have an indirect effect through its influence on intervening variables (e.g., patient understanding, clinician-patient agreement on treatment, adherence to treatment). For example, a patient communication skills intervention may not directly improve pain control for cancer patients. However, it may do so indirectly by activating patients to talk about cancer pain, which prompts the physician to change pain medication, which leads to better pain control. Additionally, communication measurement is complicated because relationships among communication behavior, meaning, and evaluation are complex.
   Conclusion: Researchers must do more to model pathways linking clinician-patient communication to the outcomes of interest, particularly pathways in which the communication effects are indirect or mediated through other variables. To better explicate how communication contributes to health outcomes, researchers must critically reflect on the assumptions they are making about communication process and choose measures consistent with those assumptions. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Street, Richard L., Jr.] Texas A&M Univ, Dept Commun, College Stn, TX 77843 USA.
   [Street, Richard L., Jr.] Baylor Coll Med, Dept Med, Sect Hlth Serv Res, Houston Ctr Qual Care & Utilizat Studies, Houston, TX 77030 USA.
C3 Texas A&M University System; Texas A&M University College Station;
   Baylor College of Medicine
RP Street, RL (corresponding author), Texas A&M Univ, Dept Commun, College Stn, TX 77843 USA.
EM r-street@tamu.edu
CR Agha Z, 2009, J MED INTERNET RES, V11, DOI 10.2196/jmir.1193
   [Anonymous], 2001, Crossing the Quality Chasm: A New Health System for the 21st Century
   Arora NK, 2009, PATIENT EDUC COUNS, V77, P404, DOI 10.1016/j.pec.2009.10.004
   Braddock CH, 1999, JAMA-J AM MED ASSOC, V282, P2313, DOI 10.1001/jama.282.24.2313
   Brown JB, 2001, WORKING PAPER SERIES
   de Haes H, 2009, PATIENT EDUC COUNS, V74, P287, DOI 10.1016/j.pec.2008.12.006
   Elwyn G, 2005, HEALTH EXPECT, V8, P34, DOI 10.1111/j.1369-7625.2004.00311.x
   Epstein RM, 2005, SOC SCI MED, V61, P1516, DOI 10.1016/j.socscimed.2005.02.001
   Epstein RM., 2007, Patient-centered communication in cancer care: promoting healing and reducing suffering
   Fogarty LA, 1999, J CLIN ONCOL, V17, P371, DOI 10.1200/JCO.1999.17.1.371
   Gallagher TH, 1997, J GEN INTERN MED, V12, P663, DOI 10.1046/j.1525-1497.1997.07137.x
   Glasgow RE, 2006, HEALTH PROMOT INT, V21, P245, DOI 10.1093/heapro/dal017
   Heisler M, 2003, J GEN INTERN MED, V18, P893, DOI 10.1046/j.1525-1497.2003.21132.x
   Jager AJ, 2012, J HEALTH COMMUN, V17, P294, DOI 10.1080/10810730.2012.712624
   KAPLAN SH, 1989, MED CARE, V27, pS110, DOI 10.1097/00005650-198903001-00010
   Kinmonth AL, 1998, BMJ-BRIT MED J, V317, P1202, DOI 10.1136/bmj.317.7167.1202
   Kravitz RL, 2012, J PAIN SYMPTOM MANAG, V43, P874, DOI 10.1016/j.jpainsymman.2011.05.020
   Kravitz RL, 2011, PAIN, V152, P1572, DOI 10.1016/j.pain.2011.02.047
   Kravitz RL, 2009, BMC CANCER, V9, DOI 10.1186/1471-2407-9-319
   Krupat E, 2006, PATIENT EDUC COUNS, V62, P38, DOI 10.1016/j.pec.2005.04.015
   Lafata JE, 2011, AM J PREV MED, V41, P480, DOI 10.1016/j.amepre.2011.07.018
   LERMAN CE, 1990, J GEN INTERN MED, V5, P29, DOI 10.1007/BF02602306
   Mead N, 2000, PATIENT EDUC COUNS, V39, P71, DOI 10.1016/S0738-3991(99)00092-0
   ORTH JE, 1987, HEALTH PSYCHOL, V6, P29, DOI 10.1037/0278-6133.6.1.29
   Papathanassoglou EDE, 2012, BIOL RES NURS, V14, P431, DOI 10.1177/1099800412451312
   Rimal RN, 2001, HEALTH COMMUN, V13, P89, DOI 10.1207/S15327027HC1301_08
   Robinson JD, 2013, J CLIN ONCOL, V31, P351, DOI 10.1200/JCO.2012.44.2699
   ROST KM, 1991, DIABETES CARE, V14, P881, DOI 10.2337/diacare.14.10.881
   Roter D, 2002, PATIENT EDUC COUNS, V46, P243, DOI 10.1016/S0738-3991(02)00012-5
   Saba GW, 2006, ANN FAM MED, V4, P54, DOI 10.1370/afm.393
   Smith A, 2011, PATIENT EDUC COUNS, V82, P233, DOI 10.1016/j.pec.2010.04.001
   Stewart M, 2000, J FAM PRACTICE, V49, P796
   Street RL, 2012, PATIENT EDUC COUNS, V89, P245, DOI 10.1016/j.pec.2012.06.032
   Street RL, 2012, EXPERT REV PHARM OUT, V12, P167, DOI [10.1586/erp.12.3, 10.1586/ERP.12.3]
   Street RL, 2009, PATIENT EDUC COUNS, V74, P295, DOI 10.1016/j.pec.2008.11.015
   STREET RL, 1992, MED CARE, V30, P976, DOI 10.1097/00005650-199211000-00002
   Street RL, 2001, HEALTH COMMUN, V13, P61, DOI 10.1207/S15327027HC1301_06
   Street RL, 1997, MED DECIS MAKING, V17, P298, DOI 10.1177/0272989X9701700306
   STREET RL, 1993, DIABETES CARE, V16, P714, DOI 10.2337/diacare.16.5.714
   Suarez-Almazor ME, 2010, ARTHRIT CARE RES, V62, P1229, DOI 10.1002/acr.20225
   Ward MM, 2003, ARTHRIT RHEUM-ARTHR, V49, P810, DOI 10.1002/art.11467
   Williams GC, 1998, HEALTH PSYCHOL, V17, P269, DOI 10.1037/0278-6133.17.3.269
   Williams GC, 2004, HEALTH PSYCHOL, V23, P58, DOI 10.1037/0278-6133.23.1.58
   Wolf MS, 2007, PATIENT EDUC COUNS, V67, P293, DOI 10.1016/j.pec.2007.03.024
   Wunderlich T, 2010, PATIENT EDUC COUNS, V80, P358, DOI 10.1016/j.pec.2010.06.034
NR 45
TC 214
Z9 258
U1 1
U2 54
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0738-3991
J9 PATIENT EDUC COUNS
JI Patient Educ. Couns.
PD SEP
PY 2013
VL 92
IS 3
SI SI
BP 286
EP 291
DI 10.1016/j.pec.2013.05.004
PG 6
WC Public, Environmental & Occupational Health; Social Sciences,
   Interdisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH); Conference Proceedings Citation Index - Science (CPCI-S)
SC Public, Environmental & Occupational Health; Social Sciences - Other
   Topics
GA 221KM
UT WOS:000324657800002
PM 23746769
DA 2026-01-16
ER

PT J
AU Gim, GT
   Lee, JH
   Park, E
   Sung, YH
   Kim, CJ
   Hwang, WW
   Chu, JP
   Min, BI
AF Gim, Gyeong-Taek
   Lee, Ji-hye
   Park, Eunkuk
   Sung, Yun-Hee
   Kim, Chang-Ju
   Hwang, Wei-wan
   Chu, Jong-Phil
   Min, Byung-Il
TI Electroacupuncture attenuates mechanical and warm allodynia through
   suppression of spinal glial activation in a rat model of neuropathic
   pain
SO BRAIN RESEARCH BULLETIN
LA English
DT Article
DE Neuropathic pain; Glial activation; Electroacupuncture; Matrix
   metalloproteinase; Proinflammatory cytokine
ID CAUDAL TRUNK INJURY; MATRIX METALLOPROTEINASES; SEROTONERGIC RECEPTORS;
   ELECTRICAL-STIMULATION; MICROGLIAL ACTIVATION; CYTOKINE EXPRESSION;
   INFLAMMATORY PAIN; INHIBITORY SYSTEM; NMDA RECEPTORS; FOS EXPRESSION
AB Neuropathic pain remains one of the most difficult clinical pain syndromes to treat. It is traditionally viewed as being mediated solely by neurons; however, glial cells have recently been implicated as powerful modulators of pain. It is known that the analgesic effects of electroacupuncture (EA) are mediated by descending pain inhibitory systems, which mainly involve spinal opioid, adrenergic, dopaminergic, serotonergic, and cholinergic receptors. However, studies investigating the suppressive effects of EA on spinal glial activation are rare. In the present study, we assessed the cumulative analgesic effects of EA on mechanical and warm allodynia in a rat model of neuropathic pain. We investigated the clinical efficacy of EA as long-term therapy and examined its effects on spinal glia, matrix metalloproteinase (MMP)-9/MMP-2, proinflammatory cytokines and serum immunoglobulin G (IgG) concentration. Rats were randomly divided into four groups as follows: the operation group (OP), operation with EA-non acupoint (EA-NA), operation with EA-ST36 acupoint (EA-ST36), and sham operation (shamOP). Following neuropathic or sham surgery, repeated EA was performed every other day after the behavioral test. On day 53 after the behavioral test, rats were perfused for immunohistochemistry and Western blot analysis to observe quantitative changes in spinal glial markers such as OX-42, astrocytic glial fibrillary acidic protein (GFAP), MMP-9/MMP-2, and proinflammatory cytokines. Allodynia and OX-42/GFAP/MMP-9/MMP-2/tumor necrosis factor (TNF)-alpha/interleukin (IL)-1 beta activity in the EA-ST36 group was significantly reduced, compared to the OP and EA-NA groups, and IgG in EA-ST36 rats significantly increased. Our results suggest that the analgesic effect of EA may be partly mediated via inhibition of inflammation and glial activation and repeated EA stimulation may be useful for treating chronic pain clinically. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Sung, Yun-Hee; Kim, Chang-Ju; Min, Byung-Il] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul 130701, South Korea.
   [Gim, Gyeong-Taek; Lee, Ji-hye; Min, Byung-Il] Kyung Hee Univ, Grad Sch, Dept EW Med, Seoul 130701, South Korea.
   [Park, Eunkuk; Chu, Jong-Phil] Kyung Hee Univ, Coll Med, Dept Med Zool, Seoul 130701, South Korea.
   [Hwang, Wei-wan] Kyung Hee Univ, Med Ctr, Hosp Korean Med, Dept Neuropsychiat, Seoul 130701, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University; Kyung
   Hee University; Kyung Hee University Hospital
RP Min, BI (corresponding author), Kyung Hee Univ, Coll Med, Dept Physiol, 1 Hoegi Dong, Seoul 130701, South Korea.
EM mbi@khu.ac.kr
RI MIN, B. I./U-3364-2017; Kim, Chang-Ju/M-4216-2017; park,
   eunkuk/MXL-4258-2025
OI Kim, Chang-Ju/0000-0003-4749-5795; park, eunkuk/0000-0002-1928-5531
FU Kyung Hee University [KHU-20100654]
FX This research was supported by the Kyung Hee University Research Fund in
   2010 (KHU-20100654).
CR Baek YH, 2005, BRAIN RES, V1057, P181, DOI 10.1016/j.brainres.2005.07.014
   Bridges D, 2001, BRIT J ANAESTH, V87, P12, DOI 10.1093/bja/87.1.12
   Butera JA, 2007, J MED CHEM, V50, P2543, DOI 10.1021/jm061015w
   Chang FC, 2004, J BIOMED SCI, V11, P179, DOI 10.1159/000076030
   CHAPLAN SR, 1994, J NEUROSCI METH, V53, P55, DOI 10.1016/0165-0270(94)90144-9
   Chen Yun-Fei, 2008, Zhongguo Zhen Jiu, V28, P675
   Cherkin DC, 2003, ANN INTERN MED, V138, P898, DOI 10.7326/0003-4819-138-11-200306030-00011
   Choi DC, 2010, NEUROBIOL DIS, V39, P272, DOI 10.1016/j.nbd.2010.04.003
   Cobacho N, 2010, BRAIN RES BULL, V83, P304, DOI 10.1016/j.brainresbull.2010.08.012
   Dai Y, 2001, J PAIN, V2, P151, DOI 10.1054/jpai.2001.19964
   DeLeo JA, 2001, PAIN, V90, P1, DOI 10.1016/S0304-3959(00)00490-5
   DeLeo JA, 2004, NEUROSCIENTIST, V10, P40, DOI 10.1177/1073858403259950
   DIXON WJ, 1980, ANNU REV PHARMACOL, V20, P441, DOI 10.1146/annurev.pa.20.040180.002301
   Dong H, 2009, NEUROL RES, V31, P853, DOI 10.1179/174313209X393960
   Dong ZQ, 2006, BRAIN RES BULL, V69, P30, DOI 10.1016/j.brainresbull.2005.08.027
   Eisenach JC, 1999, LIFE SCI, V64, P549, DOI 10.1016/S0024-3205(98)00600-6
   Gao X, 1998, Sheng Li Xue Bao, V50, P43
   GIULIAN D, 1994, NEUROCHEM INT, V25, P227, DOI 10.1016/0197-0186(94)90066-3
   Gok B, 2009, J CLIN NEUROSCI, V16, P549, DOI 10.1016/j.jocn.2008.04.024
   Guan Z, 1995, J Tradit Chin Med, V15, P102
   Han J S., 1987, The neurochemical basis of pain relief by acupuncture
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   He TF, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1155/2011/290489
   Huang C, 2004, NEUROSCI LETT, V368, P327, DOI 10.1016/j.neulet.2004.07.073
   Hwang BG, 2002, NEUROSCI LETT, V320, P49, DOI 10.1016/S0304-3940(02)00027-7
   Kang JM, 2007, BRAIN RES, V1131, P211, DOI 10.1016/j.brainres.2006.10.089
   Kaptchuk TJ, 2002, ANN INTERN MED, V136, P374, DOI 10.7326/0003-4819-136-5-200203050-00010
   Kavoussi B, 2007, INTEGR CANCER THER, V6, P251, DOI 10.1177/1534735407305892
   Kawasaki Y, 2008, NAT MED, V14, P331, DOI 10.1038/nm1723
   Kim HY, 2009, PAIN, V145, P332, DOI 10.1016/j.pain.2009.06.035
   Kim JH, 2004, BRAIN RES, V998, P230, DOI 10.1016/j.brainres.2003.11.045
   Kim JH, 2000, NEUROSCI LETT, V279, P149, DOI 10.1016/S0304-3940(99)00994-5
   Kim SK, 2005, EXP NEUROL, V195, P430, DOI 10.1016/j.expneurol.2005.06.018
   Kim SK, 2010, AUTON NEUROSCI-BASIC, V157, P38, DOI 10.1016/j.autneu.2010.03.010
   Kim YI, 1997, NEUROREPORT, V8, P2149, DOI 10.1097/00001756-199707070-00011
   Ledeboer A, 2005, PAIN, V115, P71, DOI 10.1016/j.pain.2005.02.009
   Li A, 2007, BRAIN RES, V1186, P171, DOI 10.1016/j.brainres.2007.10.022
   MALMBERG AB, 1995, BRIT J PHARMACOL, V114, P1069, DOI 10.1111/j.1476-5381.1995.tb13315.x
   Mika J, 2009, EUR J PHARMACOL, V623, P65, DOI 10.1016/j.ejphar.2009.09.030
   Millan MJ, 2002, PROG NEUROBIOL, V66, P355, DOI 10.1016/S0301-0082(02)00009-6
   Milligan ED, 2003, J NEUROSCI, V23, P1026
   Missale C, 1998, PHYSIOL REV, V78, P189, DOI 10.1152/physrev.1998.78.1.189
   NA HS, 1994, NEUROSCI LETT, V177, P50, DOI 10.1016/0304-3940(94)90042-6
   Namaka M, 2004, CLIN THER, V26, P951, DOI 10.1016/S0149-2918(04)90171-3
   Park JH, 2009, J PHYSIOL SCI, V59, P291, DOI 10.1007/s12576-009-0035-9
   Park JH, 2010, BRAIN RES, V1322, P24, DOI 10.1016/j.brainres.2010.02.001
   Parks WC, 2004, NAT REV IMMUNOL, V4, P617, DOI 10.1038/nri1418
   Raghavendra V, 2003, J PHARMACOL EXP THER, V306, P624, DOI 10.1124/jpet.103.052407
   Rosenberg GA, 2002, GLIA, V39, P279, DOI 10.1002/glia.10108
   Shan S, 2007, NEUROBIOL DIS, V26, P558, DOI 10.1016/j.nbd.2007.02.007
   Shapiro S, 2002, CANCER, V95, P2032, DOI 10.1002/cncr.10905
   Sommer C, 1997, NEUROSCI LETT, V237, P45, DOI 10.1016/S0304-3940(97)00813-6
   Sun RQ, 2004, EXP NEUROL, V187, P23, DOI 10.1016/j.expneurol.2003.12.011
   Sun S, 2008, BRAIN RES BULL, V75, P83, DOI 10.1016/j.brainresbull.2007.07.027
   Sweitzer SM, 2001, J PHARMACOL EXP THER, V297, P1210
   TAKESHIGE C, 1992, BRAIN RES BULL, V29, P617, DOI 10.1016/0361-9230(92)90131-G
   Talhouk RS, 2000, PAIN, V84, P397, DOI 10.1016/S0304-3959(99)00238-9
   Tawfik VL, 2007, BRAIN BEHAV IMMUN, V21, P238, DOI 10.1016/j.bbi.2006.07.001
   Vallejo R, 2010, PAIN PRACT, V10, P167, DOI 10.1111/j.1533-2500.2010.00367.x
   Wang J, 2009, BRAIN RES BULL, V80, P89, DOI 10.1016/j.brainresbull.2009.04.020
   Wang LN, 2006, BRAIN RES, V1120, P46, DOI 10.1016/j.brainres.2006.08.077
   Watkins LR, 2005, TRENDS NEUROSCI, V28, P661, DOI 10.1016/j.tins.2005.10.001
   Watkins LR, 2003, NAT REV DRUG DISCOV, V2, P973, DOI 10.1038/nrd1251
   Watkins LR, 2001, TRENDS NEUROSCI, V24, P450, DOI 10.1016/S0166-2236(00)01854-3
   XIONG W, 2007, CHIN J REHABIL
   YANG MMP, 1989, AM J CHINESE MED, V17, P89, DOI 10.1142/S0192415X89000152
   Yim YK, 2007, EVID-BASED COMPL ALT, V4, P51, DOI 10.1093/ecam/nel054
   Zhuang ZY, 2005, PAIN, V114, P149, DOI 10.1016/j.pain.2004.12.022
   ZIMMERMANN M, 1983, PAIN, V16, P109, DOI 10.1016/0304-3959(83)90201-4
NR 69
TC 54
Z9 68
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
EI 1873-2747
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD NOV 25
PY 2011
VL 86
IS 5-6
BP 403
EP 411
DI 10.1016/j.brainresbull.2011.09.010
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 871AZ
UT WOS:000298711300017
PM 21958939
DA 2026-01-16
ER

PT J
AU Cho, N
   Choi, Y
   Kim, H
   Yun, J
   Jun, H
   Yang, C
   Kim, S
   Leem, J
AF Cho, Nahyun
   Choi, Younkuk
   Kim, Heekyung
   Yun, Jeongmi
   Jun, Hyungsun
   Yang, Changsop
   Kim, Sungha
   Leem, Jungtae
TI Pain Treatment in Primary Care Through Eight Constitution Medicine: A
   Retrospective Real-World Study from South Korea
SO MEDICINA-LITHUANIA
LA English
DT Article
DE acupuncture; precision medicine; musculoskeletal pain; healthy
   lifestyle; retrospective studies
ID CROSS-CULTURAL ADAPTATION; NECK DISABILITY INDEX; WESTERN ONTARIO;
   VALIDATION; QUESTIONNAIRE; VERSION; OSTEOARTHRITIS; RELIABILITY;
   PAINDETECT; WOMAC
AB Background and Objectives: Musculoskeletal pain is a global public health issue. Eight Constitution Medicine (ECM), a type of East Asian Traditional Medicine, offers personalized, minimally invasive treatment through Eight Constitution Acupuncture (ECA) and Eight Constitution Lifestyle Intervention (ECLI). Despite its clinical use, scientific evidence supporting ECM's effectiveness remains limited. This study aimed to evaluate the effectiveness in treating musculoskeletal pain in primary care settings. Materials and Methods: This retrospective study analyzed medical records from three ECM clinics (Gangnam-Shingwang, Yeson, and Yebon) between January 2018 and August 2023. A total of 163 patients were included, with 44 providing follow-up data. Pain intensity, quality of life, and functional outcomes were assessed using validated instruments including the PainDETECT questionnaire, Korean Cancer Pain Assessment Tool (KCPAT) somatic pain scores, EuroQol 5-Dimension 5-Level (EQ-5D-5L), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Oswestry Disability Index (ODI), Neck Disability Index (NDI), and Shoulder Pain and Disability Index (SPADI). Pre- and post-treatment scores were statistically analyzed. Results: Significant decreases were observed in KCPAT somatic pain scores (11.77 +/- 4.77 to 9.77 +/- 5.32) and significant improvements in EQ-5D-5L scores (0.74 +/- 0.12 to 0.80 +/- 0.07). WOMAC and ODI scores also showed significant improvements. However, the changes in the NDI, SPADI, and PainDETECT scores were not statistically significant. No adverse events were reported. Conclusions: ECM, through ECA and ECLI, may offer effective personalized treatment for musculoskeletal pain, improving both pain intensity and quality of life. Despite its small sample size and retrospective design, this study offers valuable preliminary evidence for ECM. Further large-scale prospective studies are needed to confirm these findings.
C1 [Cho, Nahyun; Leem, Jungtae] Wonkwang Univ, Coll Korean Med, Dept Diagnost, Iksan 54538, South Korea.
   [Cho, Nahyun] Daejeon Univ, Cheonan Korean Med Hosp, East West Canc Ctr, Daejeon 34520, South Korea.
   [Choi, Younkuk; Kim, Heekyung] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Clin Res Design & Evaluat, Seoul 06355, South Korea.
   [Choi, Younkuk] Gangnam Shingwang ECM Clin, Seoul 06612, South Korea.
   [Kim, Heekyung] Yebon ECM Clin, Seoul 05510, South Korea.
   [Yun, Jeongmi] Yeson ECM Clin, Seoul 07999, South Korea.
   [Jun, Hyungsun] Dongshin Univ, Coll Korean Med, Dept Diagnost, Naju 58245, South Korea.
   [Yang, Changsop] Korea Inst Oriental Med, KM Sci Res Div, Daejeon 34054, South Korea.
   [Kim, Sungha] Korea Inst Oriental Med, Clin Med Div, Daejeon 34054, South Korea.
   [Leem, Jungtae] Wonkwang Univ, Coll Korean Med, Res Ctr Tradit Korean Med, Iksan 54538, South Korea.
   [Leem, Jungtae] Wonkwang Univ, Dept Ilwon Integrated Med, Korean Med Hosp, 895 Muwang Ro, Iksan 54538, South Korea.
C3 Wonkwang University; Daejeon University; Samsung; Sungkyunkwan
   University (SKKU); Dongshin University; Korea Institute of Oriental
   Medicine (KIOM); Korea Institute of Oriental Medicine (KIOM); Wonkwang
   University; Wonkwang University
RP Leem, J (corresponding author), Wonkwang Univ, Coll Korean Med, Dept Diagnost, Iksan 54538, South Korea.; Kim, S (corresponding author), Korea Inst Oriental Med, Clin Med Div, Daejeon 34054, South Korea.; Leem, J (corresponding author), Wonkwang Univ, Coll Korean Med, Res Ctr Tradit Korean Med, Iksan 54538, South Korea.; Leem, J (corresponding author), Wonkwang Univ, Dept Ilwon Integrated Med, Korean Med Hosp, 895 Muwang Ro, Iksan 54538, South Korea.
EM jnh528@naver.com; pyrologos@gmail.com; yebon8@gmail.com;
   yeson1004@naver.com; hs14231423@naver.com; yangunja@kiom.re.kr;
   bozzol@kiom.re.kr; julcho0908@wku.ac.kr
RI ; Yang, Changsop/F-5897-2014; Leem, Jungtae/LGY-7782-2024
OI , HeeKyung/0000-0002-6942-8289; Choi, Younkuk/0009-0005-1206-4989; Kim,
   Sungha/0000-0001-5542-3850; Yang, Changsop/0000-0003-1277-3329; Cho,
   Nahyun/0009-0008-8164-1331; Leem, Jungtae/0000-0003-3300-5556
FU Bio&Medical Technology Development Program of the National Research
   Foundation (NRF) [RS-2023-00261934]; Bio&Medical Technology Development
   Program of the National Research Foundation (NRF) - Korean government
   (MSIT) [RS-2022-NR072366]; National Research Foundation of Korea - Korea
   government [KSN2122211]; Korea Institute of Oriental Medicine
FX This research was supported by the Bio&Medical Technology Development
   Program of the National Research Foundation (NRF) funded by the Korean
   government (MSIT) (No. RS-2023-00261934) and National Research
   Foundation of Korea grant funded by the Korea government
   (RS-2022-NR072366), which was received by Jungtae Leem. This work was
   also supported by the Korea Institute of Oriental Medicine (No.
   KSN2122211), which provided funding to Sungha Kim.
CR Al-Boloushi Z, 2019, J BODYW MOV THER, V23, P122, DOI 10.1016/j.jbmt.2018.05.002
   Almutairi NM, 2022, HEALTHCARE-BASEL, V10, DOI 10.3390/healthcare10071176
   Bae SC, 2001, OSTEOARTHR CARTILAGE, V9, P746, DOI 10.1053/joca.2001.0471
   BELLAMY N, 1988, J RHEUMATOL, V15, P1833
   Bilton K, 2016, J ALTERN COMPLEM MED, V22, P599, DOI 10.1089/acm.2016.0056
   채상진, 2004, Journal of Acupuncture Research, V21, P65
   Chae S.-J., 2001, J. Acupunct. Res, V18, P48
   Chen J, 2023, J ORTHOP SURG RES, V18, DOI 10.1186/s13018-023-04403-2
   Cho N, 2025, FRONT MED-LAUSANNE, V12, DOI 10.3389/fmed.2025.1545687
   Choi YS, 2006, J PAIN SYMPTOM MANAG, V31, P553, DOI 10.1016/j.jpainsymman.2005.10.008
   Choi Y, 2024, INTEGR MED REP, V3, P19, DOI 10.1089/imr.2023.0039
   Coretti S, 2014, EXPERT REV PHARM OUT, V14, P221, DOI 10.1586/14737167.2014.894462
   Ehrich EW, 2000, J RHEUMATOL, V27, P2635
   Fairbank JCT, 2000, SPINE, V25, P2940, DOI 10.1097/00007632-200011150-00017
   Freynhagen R, 2006, CURR MED RES OPIN, V22, P1911, DOI 10.1185/030079906X132488
   Green S, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005319
   Gwinnutt JM, 2023, ANN RHEUM DIS, V82, P48, DOI 10.1136/annrheumdis-2021-222020
   Herdman M, 2011, QUAL LIFE RES, V20, P1727, DOI 10.1007/s11136-011-9903-x
   Hinman RS, 2014, JAMA-J AM MED ASSOC, V312, P1313, DOI 10.1001/jama.2014.12660
   Ho RST, 2022, INTEGR MED RES, V11, DOI 10.1016/j.imr.2021.100771
   김희경, 2009, [The Journal of Korean Medicine Ophthalmology&Otorhinolaryngology&Dermatology, 한방안이비인후피부과학회지], V22, P251
   Hsu Elisabeth., 2010, Pulse Diagnosis in Early Chinese Medicine
   Jeon CH, 2006, J KOREAN MED SCI, V21, P1092, DOI 10.3346/jkms.2006.21.6.1092
   조병제, 2013, [Journal of Korean Medicine, 대한한의학회지], V34, P143
   Kim Chang-Keun, 2020, [Journal of Korean Medicine, 대한한의학회지], V41, P41, DOI 10.13048/jkm.20042
   Kim HJ, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019074
   Kim MK, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/2376581
   Kim SH, 2016, QUAL LIFE RES, V25, P1845, DOI 10.1007/s11136-015-1205-2
   Kim Y., 2003, J. Acupunct. Res, V20, P202
   Kim YE, 2019, J KOREAN MED SCI, V34, DOI 10.3346/jkms.2019.34.e75
   Kuon D., 1974, J. Myong Ji Univ, V7, P583
   Kuon D, 2011, ADV MED BIOL, V5, P243
   Mu JL, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013814
   Oh IH, 2011, BMC MUSCULOSKEL DIS, V12, DOI 10.1186/1471-2474-12-157
   Park J., 2022, Med. Policy Forum, V20, P19
   Paul A, 2004, ANN RHEUM DIS, V63, P1293, DOI 10.1136/ard.2003.012088
   Pinto JW, 2021, J ALTERN COMPLEM MED, V27, P238, DOI 10.1089/acm.2020.0365
   Pool JJM, 2007, SPINE, V32, P3047, DOI 10.1097/BRS.0b013e31815cf75b
   Ramaswami R, 2018, ANNU REV PUBL HEALTH, V39, P153, DOI 10.1146/annurev-publhealth-040617-014158
   Roach K E, 1991, Arthritis Care Res, V4, P143, DOI 10.1002/art.1790040403
   Safiri S, 2021, ARTHRITIS RHEUMATOL, V73, P702, DOI 10.1002/art.41571
   Seo Hyun-Du, 2012, 특수교육재활과학연구, V51, P319
   Shin Yong-Sup, 2009, Oriental Pharmacy and Experimental Medicine, V9, P14
   Song KJ, 2010, SPINE, V35, pE1045, DOI 10.1097/BRS.0b013e3181df78e9
   Sung JK, 2017, PAIN PRACT, V17, P494, DOI 10.1111/papr.12472
   Tangkiatkumjai M, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-03157-2
   The Society of Korean Medicine Diagnostics Department of Biofunctional Medicine of Korean Medical University, 2008, Biofunctional Medicine
   Ussai S, 2015, DRUG DES DEV THER, V9, P2073, DOI 10.2147/DDDT.S80686
   VERNON H, 1991, J MANIP PHYSIOL THER, V14, P409
   Yoo SK, 2013, SPRINGERPLUS, V2, DOI 10.1186/2193-1801-2-406
   Yu WJ, 2017, AM J CHINESE MED, V45, P1, DOI 10.1142/S0192415X1750001X
   Yuan QL, 2015, PLOS ONE, V10, DOI [10.1371/journal.pone.0117146, 10.1371/journal.pone.0119403]
   Yun H.M., 2001, J. Dong-Eui Orient. Med, V5, P67
   Yun J., 2022, Protocol Development of Eight Constitution Medicine Registry for Chronic Low Back Pain
NR 54
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD AUG 30
PY 2025
VL 61
IS 9
AR 1564
DI 10.3390/medicina61091564
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7VD2T
UT WOS:001580396900001
PM 41010955
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Tan, T
   Li, SQ
   Meghani, SH
   Glanz, K
   Bruner, D
AF Mao, Jun J.
   Tan, Tiffany
   Li, Susan Q.
   Meghani, Salimah H.
   Glanz, Karen
   Bruner, Deborah
TI Attitudes and barriers towards participation in an acupuncture trial
   among breast cancer patients: a survey study
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Acupuncture; Breast neoplasm; Clinical trial; Aromatase
   inhibitors/*adverse effects; Musculoskeletal; Joint pain; Attitudes;
   Barriers
ID ALTERNATIVE MEDICINE USE; RANDOMIZED CLINICAL-TRIALS;
   COMPLEMENTARY/ALTERNATIVE MEDICINE; EXPECTANCY SCALE; SURVIVORS; WOMEN;
   WILLINGNESS; ONCOLOGY; IMPACT; RACE
AB Background: As breast cancer patients increasingly use complementary and alternative medicine (CAM), clinical trials are needed to guide appropriate clinical use. We sought to identify socio-demographic, clinical and psychological factors related to willingness to participate (WTP) and to determine barriers to participation in an acupuncture clinical trial among breast cancer patients.
   Methods: We conducted a cross-sectional survey study among post-menopausal women with stage I-III breast cancer on aromatase inhibitors at an urban academic cancer center.
   Results: Of the 300 participants (92% response rate), 148 (49.8%) reported WTP in an acupuncture clinical trial. Higher education (p = 0.001), increased acupuncture expectancy (p < 0.001), and previous radiation therapy (p = 0.004) were significantly associated with WTP. Travel difficulty (p = 0.002), concern with experimentation (p = 0.013), and lack of interest in acupuncture (p < 0.001) were significant barriers to WTP. Barriers differed significantly by socio-demographic factors with white people more likely to endorse travel difficulty (p = 0.018) and non-white people more likely to report concern with experimentation (p = 0.024). Older patients and those with lower education were more likely to report concern with experimentation and lack of interest in acupuncture (p < 0.05).
   Conclusions: Although nearly half of the respondents reported WTP, significant barriers to participation exist and differ among subgroups. Research addressing these barriers is needed to ensure effective accrual and improve the representation of individuals from diverse backgrounds.
C1 [Mao, Jun J.; Tan, Tiffany; Li, Susan Q.] Univ Penn, Perelman Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA.
   [Mao, Jun J.; Glanz, Karen] Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
   [Mao, Jun J.; Glanz, Karen] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
   [Tan, Tiffany; Meghani, Salimah H.; Glanz, Karen] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA.
   [Bruner, Deborah] Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of Pennsylvania
RP Mao, JJ (corresponding author), Univ Penn, Perelman Sch Med, Dept Family Med & Community Hlth, 3400 Spruce St,2 Gates Bldg, Philadelphia, PA 19104 USA.
EM jun.mao@uphs.upenn.edu
RI ; Tan, Tiffany/HOC-8176-2023; Mao, Jun/F-5009-2012
OI Meghani, Salimah/0000-0002-5866-8279; Bruner,
   Deborah/0000-0002-5770-9948; 
FU American Cancer Society [IRF-78-002-30]; University of Pennsylvania
   Center for Undergraduate Research and Fellowships; National Institute of
   Health/National Center for Complementary and Alternative Medicine [R21
   AT004695, K23004112]
FX This study is in part supported by a grant from the American Cancer
   Society #IRF-78-002-30. Dr. Mao is also a recipient of the National
   Institute of Health/National Center for Complementary and Alternative
   Medicine grants R21 AT004695 and K23004112. Ms. Tan is supported by a
   grant from the University of Pennsylvania Center for Undergraduate
   Research and Fellowships. The funding agencies had no role in the design
   and conduct of the study. Sincere thanks also go to the patients,
   oncologists, nurse practitioners and staff for their support of this
   study.
CR Agrawal M, 2006, J CLIN ONCOL, V24, P4479, DOI 10.1200/JCO.2006.06.0269
   Baggstrom MQ, 2011, J THORAC ONCOL, V6, P98, DOI 10.1097/JTO.0b013e3181fb50d8
   Baker F, 2005, CANCER, V104, P2565, DOI 10.1002/cncr.21488
   Boon Heather S, 2007, BMC Womens Health, V7, P4, DOI 10.1186/1472-6874-7-4
   Brauer JA, 2010, J ALTERN COMPLEM MED, V16, P183, DOI 10.1089/acm.2009.0354
   Cheng SK, 2011, CLIN CANCER RES, V17, P1947, DOI 10.1158/1078-0432.CCR-10-1730
   Cheng SK, 2010, CLIN CANCER RES, V16, P5557, DOI 10.1158/1078-0432.CCR-10-0133
   Colagiuri B, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/857804
   Comis RL, 2003, J CLIN ONCOL, V21, P830, DOI 10.1200/JCO.2003.02.105
   Corbie-Smith G, 1999, J GEN INTERN MED, V14, P537, DOI 10.1046/j.1525-1497.1999.07048.x
   Corbie-Smith G, 2002, ARCH INTERN MED, V162, P2458, DOI 10.1001/archinte.162.21.2458
   Ellis Peter M., 1999, Health Expect, V2, P33, DOI 10.1046/j.1369-6513.1999.00028.x
   Ellis PM, 2001, J CLIN ONCOL, V19, P3554, DOI 10.1200/JCO.2001.19.15.3554
   Ellis PM, 2000, ANN ONCOL, V11, P939, DOI 10.1023/A:1008342222205
   Gross CP, 2005, CANCER, V103, P483, DOI 10.1002/cncr.20792
   Harrington CB, 2010, INT J PSYCHIAT MED, V40, P163, DOI 10.2190/PM.40.2.c
   Jacobson JS, 2000, J CLIN ONCOL, V18, P668, DOI 10.1200/JCO.2000.18.3.668
   Jones LW, 2006, LANCET ONCOL, V7, P1017, DOI 10.1016/S1470-2045(06)70976-7
   Kong J, 2009, NEUROIMAGE, V47, P1066, DOI 10.1016/j.neuroimage.2009.05.087
   Lamberti MJ, 2009, STATE CLIN TRIALS IN
   Lara PN Jr, 2005, J CLIN ONCOL, V23, P9282, DOI 10.1200/JCO.2005.02.6245
   Lee MM, 2000, JNCI-J NATL CANCER I, V92, P42, DOI 10.1093/jnci/92.1.42
   Levine Alison Spatz, 2012, Int J Yoga Therap, P95
   Linde K, 2007, PAIN, V128, P264, DOI 10.1016/j.pain.2006.12.006
   Mao JJ, 2007, J AM BOARD FAM MED, V20, P434, DOI 10.3122/jabfm.2007.05.060225
   Mao JJ, 2007, EXPLORE-NY, V3, P372, DOI 10.1016/j.explore.2006.12.003
   Mao JJ, 2010, ALTERN THER HEALTH M, V16, P22
   Mao JJ, 2009, CANCER, V115, P3631, DOI 10.1002/cncr.24419
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   Matthews AK, 2007, J ALTERN COMPLEM MED, V13, P555, DOI 10.1089/acm.2007.03-9040
   Mills EJ, 2006, LANCET ONCOL, V7, P141, DOI 10.1016/S1470-2045(06)70576-9
   Morris KT, 2000, AM J SURG, V179, P407, DOI 10.1016/S0002-9610(00)00358-5
   Murthy VH, 2004, JAMA-J AM MED ASSOC, V291, P2720, DOI 10.1001/jama.291.22.2720
   Nahleh Zeina, 2003, Palliat Support Care, V1, P267
   Pariente J, 2005, NEUROIMAGE, V25, P1161, DOI 10.1016/j.neuroimage.2005.01.016
   Phillips KM, 2013, PSYCHO-ONCOLOGY, V22, P936, DOI 10.1002/pon.3066
   Richardson MA, 1998, ANN BEHAV MED, V20, P190, DOI 10.1007/BF02884960
   Schneider J, 2003, J ALTERN COMPLEM MED, V9, P389, DOI 10.1089/107555303765551615
   Siegel R, 2012, CA-CANCER J CLIN, V62, P10, DOI 10.3322/caac.20138
   Trauth J M, 2000, J Health Soc Policy, V12, P23
   Upchurch DM, 2005, WOMEN HEALTH ISS, V15, P5, DOI 10.1016/j.whi.2004.08.010
   Wanchai A, 2010, CLIN J ONCOL NURS, V14, P431, DOI 10.1188/10.CJON.E45-E55
   Wyatt G, 2010, NURS RES, V59, P58, DOI 10.1097/NNR.0b013e3181c3bd26
NR 43
TC 24
Z9 27
U1 0
U2 21
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JAN 8
PY 2014
VL 14
AR 7
DI 10.1186/1472-6882-14-7
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA 294OX
UT WOS:000330057300002
PM 24400734
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yeh, CH
   Lukkahatai, N
   Campbell, C
   Sair, H
   Zhang, FZ
   Mensah, S
   Garry, C
   Zeng, J
   Chen, CY
   Pinedo, M
   Khoshnoodi, M
   Smith, TJ
   Saligan, LN
AF Yeh, Chao Hsing
   Lukkahatai, Nada
   Campbell, Claudia
   Sair, Haris
   Zhang, Fengzhi
   Mensah, Sylvanus
   Garry, Courtney
   Zeng, Jing
   Chen, Changying
   Pinedo, Mariela
   Khoshnoodi, Mohammad
   Smith, Thomas J.
   Saligan, Leorey N.
TI Preliminary Effectiveness of Auricular Point Acupressure on
   Chemotherapy-Induced Neuropathy: Part 1 Self-Reported Outcomes
SO PAIN MANAGEMENT NURSING
LA English
DT Article
ID INDUCED PERIPHERAL NEUROPATHY; INHIBITOR-INDUCED ARTHRALGIA;
   BREAST-CANCER SURVIVORS; QUALITY-OF-LIFE; CHRONIC-PAIN; PSYCHOLOGICAL
   DISTRESS; AMERICAN-SOCIETY; RISK-FACTORS; HEALTH; MANAGEMENT
AB Purpose: To reduce chemotherapy-induced neuropathy (CIN)-a significant challenge among cancer patients following chemotherapy-we explored the effects of auricular point acupressure (APA), which involves needleless, acupuncture-like stimulation on specific ear points.
   Design/Method: This pilot study examined the effects of a 4-week APA intervention in the management of CIN. Descriptive analysis was used to examine the changes in study outcomes.
   Results: Fifteen participants were enrolled. Two participants dropped out because they developed new medical conditions. Thirteen participants completed the study (87% retention rate). Study participants had more severe symptoms in their lower extremities (i.e., toes, feet, soles) than in their upper extremities (i.e., fingers, wrists, elbows). After the 4-week APA intervention, the mean percentage change scores ranged from 38% (tingling) to 49% (numbness); compared to pre-intervention, the therapeutic effects of APA were sustained at the 1-month follow-up. Function in both upper and lower extremities improved after the APA intervention (>= 28%) and continued to improve at the 1-month follow-up (>= 36%).
   Conclusions: Preliminary results from this small sample provide initial evidence of the effectiveness of APA on CIN. Future studies should confirm these results using a larger sample, a comparative sham control, and an examination of the underlying physiological mechanisms of the anti-CIN effects of APA.
   Clinical Implications: APA may provide an inexpensive and effective complementary approach for the self-management of CIN. Once the seeds have been taped to the patient's ear by the provider, patients are empowered to self-manage their CIN in their own environment. (C) 2019 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.
C1 [Yeh, Chao Hsing; Lukkahatai, Nada; Mensah, Sylvanus; Garry, Courtney; Pinedo, Mariela] Johns Hopkins Univ, Sch Nursing, 525 N Wolfe St,Room 421, Baltimore, MD 21205 USA.
   [Campbell, Claudia] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
   [Sair, Haris] Johns Hopkins Univ, Sch Med, Dept Radiol, 600 N Wolfe St,Phipps 455, Baltimore, MD 21205 USA.
   [Zhang, Fengzhi] Zhengzhou Univ, Affiliated Hosp 3, Dept Gynecol, Zhengzhou, Henan, Peoples R China.
   [Zeng, Jing] Chengdu Med Coll, Sch Nursing, Chengdu, Sichuan, Peoples R China.
   [Chen, Changying] Zhengzhou Univ, Nursing Coll, 100 Sci Ave, Zhengzhou, Henan, Peoples R China.
   [Khoshnoodi, Mohammad] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.
   [Smith, Thomas J.] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA.
   [Saligan, Leorey N.] NINR, NIH, Bethesda, MD 20892 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   University; Zhengzhou University; Chengdu Medical College; Zhengzhou
   University; Johns Hopkins University; Johns Hopkins University; Johns
   Hopkins Medicine; National Institutes of Health (NIH) - USA; NIH
   National Institute of Nursing Research (NINR)
RP Yeh, CH (corresponding author), Johns Hopkins Univ, Sch Nursing, 525 N Wolfe St,Room 421, Baltimore, MD 21205 USA.
EM cyeh13@jhu.edu
RI Saligan, Leorey/M-7101-2015; Lukkahatai, Nada/GQA-9711-2022; zeng,
   jing/JDW-4350-2023; Smith, Thomas/K-9086-2013
OI Saligan, Leorey/0000-0001-9481-7836; Lukkahatai,
   Nada/0000-0003-3820-1812; 
FU Johns Hopkins Discovery Award
FX This study was supported by a grant to Dr. Yeh from the Johns Hopkins
   Discovery Award.
CR Alimi D., 2002, MED ACUPUNCT, V13, P18
   [Anonymous], 1997, MANUAL FUNCTIONAL AS
   [Anonymous], 2014, Auriculotherapy Manual: Chinese and Western Systems of Ear Acupuncture
   [Anonymous], 1991, WHO technical working group report
   [Anonymous], 2005, Auricular Medicine: A Complete Manual of Auricular Diagnosis and Treatment
   Asher GN, 2010, J ALTERN COMPLEM MED, V16, P1097, DOI 10.1089/acm.2009.0451
   Beaton DE, 2005, J BONE JOINT SURG AM, V87A, P1038, DOI 10.2106/JBJS.D.02060
   Bellamy N., 2002, WOMAC Osteoarthritis Index user guide
   Bellingham GA, 2010, REGION ANESTH PAIN M, V35, P294, DOI 10.1097/AAP.0b013e3181df2645
   Benyamin R, 2008, PAIN PHYSICIAN, V11, pS105
   Brier MJ, 2015, CANCER-AM CANCER SOC, V121, P2808, DOI 10.1002/cncr.29407
   Campbell CM, 2009, TRANSL RES, V153, P97, DOI 10.1016/j.trsl.2008.12.002
   Candiotti KA, 2010, CURR MED RES OPIN, V26, P1677, DOI 10.1185/03007995.2010.483941
   Carullo Veronica, 2015, J Pain Palliat Care Pharmacother, V29, P378, DOI [10.3109/15360288.2015.1082006, 10.3109/15360288.2015.1082006]
   Cashion AK, 2015, NURS OUTLOOK, V63, P484, DOI 10.1016/j.outlook.2015.03.001
   CHARLSON M, 1994, J CLIN EPIDEMIOL, V47, P1245, DOI 10.1016/0895-4356(94)90129-5
   Chen Lucy, 2014, J Opioid Manag, V10, P383, DOI 10.5055/jom.2014.0235
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Desai K, 2013, SUPPORT CARE CANCER, V21, P43, DOI 10.1007/s00520-012-1490-z
   Dowell D, 2016, JAMA-J AM MED ASSOC, V315, P1624, DOI 10.1001/jama.2016.1464
   Dublin S, 2015, J AM GERIATR SOC, V63, P1519, DOI 10.1111/jgs.13562
   Dworkin RH, 2009, PAIN, V146, P238, DOI 10.1016/j.pain.2009.08.019
   Franconi G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/516916
   Gatchel RJ, 2007, PSYCHOL BULL, V133, P581, DOI 10.1037/0033-2909.133.4.581
   Gilron I, 2005, NEW ENGL J MED, V352, P1324, DOI 10.1056/NEJMoa042580
   Gilron I, 2015, PAIN, V156, P1440, DOI 10.1097/j.pain.0000000000000149
   Hays RD, 2018, QUAL LIFE RES, V27, P1885, DOI 10.1007/s11136-018-1842-3
   Hays RD, 2016, PHARMACOECONOMICS, V34, P1015, DOI 10.1007/s40273-016-0408-x
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Huang L., 2007, Handbook of Auricular Treatment Prescriptions & Formular Orlando Fl
   Hurst H, 2004, J MANIP PHYSIOL THER, V27, P26, DOI 10.1016/j.jmpt.2003.11.003
   Irwin ML, 2015, J CLIN ONCOL, V33, P1104, DOI 10.1200/JCO.2014.57.1547
   Kennedy CA, 2013, QUAL LIFE RES, V22, P2509, DOI 10.1007/s11136-013-0362-4
   Kleckner IR, 2018, SUPPORT CARE CANCER, V26, P1019, DOI 10.1007/s00520-017-4013-0
   Laroche F, 2014, J PAIN, V15, P293, DOI 10.1016/j.jpain.2013.11.004
   Lumley MA, 2011, J CLIN PSYCHOL, V67, P942, DOI 10.1002/jclp.20816
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Maixner W, 2016, J PAIN, V17, pT93, DOI 10.1016/j.jpain.2016.06.002
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Markovitz LC, 2017, PSYCHO-ONCOLOGY, V26, P2294, DOI 10.1002/pon.4362
   Miaskowski C, 2017, J PAIN SYMPTOM MANAG, V54, P204, DOI 10.1016/j.jpainsymman.2016.12.342
   Miller M, 2015, JAMA INTERN MED, V175, P608, DOI 10.1001/jamainternmed.2014.8071
   Molsberger AF, 2010, PAIN, V151, P146, DOI 10.1016/j.pain.2010.06.036
   National Center for Complementary and Integrative Health, 2015, CHRONIC PAIN
   Nogier P., 1987, POINTS REFLEXES AURI
   Nogier P., 1981, HDB AURICULOTHERAPY
   Nogier R, 2014, MED ACUPUNCT, V26, P76, DOI 10.1089/acu.2014.1035
   Otte JL, 2010, J PAIN SYMPTOM MANAG, V39, P535, DOI 10.1016/j.jpainsymman.2009.07.004
   Pergolizzi Joseph, 2008, Pain Pract, V8, P287, DOI 10.1111/j.1533-2500.2008.00204.x
   Pike C. T., 2012, CHEMOTHERAPY RES PRA, P12
   Pinsker E, 2015, FOOT ANKLE INT, V36, P617, DOI 10.1177/1071100714566624
   Poulsen JL, 2015, THER ADV GASTROENTER, V8, P360, DOI 10.1177/1756283X15589526
   Romoli M, 2014, NEUROL SCI, V35, pS189, DOI 10.1007/s10072-014-1768-7
   Rosenquist RW, 2010, ANESTHESIOLOGY, V112, P810, DOI 10.1097/ALN.0b013e3181c43103
   Schapira MM, 2014, SUPPORT CARE CANCER, V22, P1207, DOI 10.1007/s00520-013-2073-3
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Shah A, 2018, J NEUROL NEUROSUR PS, V89, P636, DOI 10.1136/jnnp-2017-317215
   Sisignano M, 2014, NAT REV NEUROL, V10, P694, DOI 10.1038/nrneurol.2014.211
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Staff NP, 2017, ANN NEUROL, V81, P772, DOI 10.1002/ana.24951
   Takei H, 2012, BREAST CANCER RES TR, V133, P227, DOI 10.1007/s10549-011-1943-y
   Winters-Stone KM, 2017, J CLIN ONCOL, V35, P2604, DOI 10.1200/JCO.2016.71.3552
   Yeh CH, 2017, ONCOL NURS FORUM, V44, P476, DOI 10.1188/17.ONF.476-487
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Yeh CH, 2015, PAIN MED, V16, P1857, DOI 10.1111/pme.12789
   Yeh CH, 2015, PAIN MANAG NURS, V16, P285, DOI 10.1016/j.pmn.2014.08.005
   Yeh CH, 2013, MED ACUPUNCT, V25, P423, DOI 10.1089/acu.2013.1006
   Yeh CH, 2014, MED ACUPUNCT, V26, P148, DOI 10.1089/acu.2014.1026
   Yeh CH, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/934670
   Yeh CH, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/375173
   Yeh CH, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/196978
   Yeh CH, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/383257
NR 72
TC 16
Z9 18
U1 2
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1524-9042
EI 1532-8635
J9 PAIN MANAG NURS
JI Pain Manag. Nurs.
PD DEC
PY 2019
VL 20
IS 6
BP 614
EP 622
DI 10.1016/j.pmn.2019.04.005
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA JT1CH
UT WOS:000500735600014
PM 31155279
DA 2026-01-16
ER

PT J
AU Wang, XQ
   Xiao, L
   Duan, PB
   Xu, Q
   Yang, LH
   Wang, AQ
   Wang, Y
AF Wang, Xiao-Qing
   Xiao, Lei
   Duan, Pei-Bei
   Xu, Qian
   Yang, Li-Hua
   Wang, A-Qin
   Wang, Yan
TI The feasibility and efficacy of perioperative auricular acupuncture
   technique via intradermal needle buried for postoperative movement-
   evoked pain after open radical gastrectomy: A randomized controlled
   pilot trial
SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
LA English
DT Article
DE Gastric cancer; Movement-evoked pain; Auricular acupuncture; Intradermal
   needle; Randomized controlled trial
AB Introduction: Auricular acupuncture is widely used in the treatment of pain. Recently, the most commonly used method of auricular acupuncture is to embed an intradermal needle into the skin to enhance analgesia through continuous stimulation. We aimed to explore the efficacy and feasibility of this form of auricular acupuncture in the treatment of postoperative movement-evoked pain. Methods: This single-blind randomized controlled pilot trial was conducted between 23/8/2019 and 10/1/ 2020. Forty patients were recruited and randomised to either the control group (n = 20) or the experimental group (n = 20). Patients in the control group received sham auricular acupuncture, while patients in the experimental group received auricular acupuncture. A standard routine analgesia was performed in both groups. The patients with NRS score>4 were given rescue analgesia. Postoperative pain, use of opioids and other analgesics, postoperative recovery and patient's satisfaction were recorded. Results: The credibility and feasibility of auricular acupuncture for postoperative pain were high in both groups. After auricular acupuncture, the scores of the postoperative movement-evoked pain had a tendency to decrease, but no significant difference was observed between two groups at any time point (P = 0.234-0.888). The data on postoperative pain at rest confirmed that no significant difference was observed between two groups within 48 h of surgery (P = 0.134-0.520), and the postoperative pain at rest scores decreased over time; however, from the third day, the pain at rest scores of the experimental group were decreased, and significant differences were observed between the two groups (P = 0.039-0.047). As for use of rescue analgesic, total opioid consumption and the incidence of postoperative nausea and vomiting, there were no significant differences between the two groups (P = 0.311, P = 0.101, P = 0.661) . In terms of patients' satisfaction, the score of the experimental group was higher than that of the control group, and a significant difference was observed between the two groups (P = 0.000). As for adverse events, two participants reported pain and one patient reported discomfort at the insertion sites during the process of auricular acupuncture intervention, but they both were minor and tolerable. Conclusion: Auricular acupuncture may have a relief effect on mild postoperative pain at rest with pain score below 3, suggesting that it may be a feasible adjuvant method to relieve mild pain at rest. However, more multi-centre and large-sample studies are needed to verify this result. (c) 2021 Elsevier Inc. All rights reserved.
C1 [Wang, Xiao-Qing] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Surg Oncol, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
   [Xiao, Lei; Duan, Pei-Bei; Wang, Yan] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Nursing, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
   [Yang, Li-Hua] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Oncol, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
   [Wang, A-Qin] Nanjing Univ Chinese Med, Sch Nursing, 138 Xianlin Rd, Nanjing 210046, Jiangsu, Peoples R China.
   [Xu, Qian] Nanjing Univ Chinese Med, Affiliated Hosp, Jiangsu Prov Hosp Chinese Med, Anesthesiol & Pain Med, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine; Nanjing University of
   Chinese Medicine; Nanjing University of Chinese Medicine
RP Duan, PB; Wang, Y (corresponding author), Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Nursing, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
EM wangxiaoqing319@126.com; xiaolei1971@163.com; dpb_58@163.com;
   xuqian36@126.com; yanglihua17@sina.com; 1078651915@qq.com;
   zyyssswy@sina.com
FU Affiliated Hospital of Nanjing University of Chinese Medicine [Y19074];
   Priority Academic Program Development of Jiangsu Higher Education
   Institutions [2019YSHL089]
FX This study was supported by a research grant from Affiliated Hospital of
   Nanjing University of Chinese Medicine (Y19074), the Priority Academic
   Program Development of Jiangsu Higher Education Institutions
   (2019YSHL089).
CR 20ShahAN MooreCB, 2019, LARYNGOSCOPE, V11
   22UsichenkoTI LehmannC, 2008, ANAESTHESIA
   23AsherG JonasD, 2010, JALTERNCOMPLEMENTMED, V16, P1097
   25KhaliliG JanghorbaniM, 2013, JCLINANESTH, V25
   29WangXQ DuanPB, 2020, EURJINTEGRMED, V33
   32LuanXW, EFFICACYOFSPECIFICAU
   34WanLS LiWS LiWY, OBSERVATIONONTHEANES
   36VictorianQualityCouncil, ACUTEPAINMANAGEMENTM
   39HawkerGA MianS KendzerskaT FrenchM, MEASURESOFADULTPAIN
   3FerlayJ ColombetM, 2019, INTJCANCER, V144
   41ScottDA McDonaldW, 2005, ACUTEPAINMANAGEMENTP
   黄琳, 1991, 控制理论与应用, V8, P11
   4BrayF FerlayJ, 2018, CANCERJCLIN
   51ClaudepierreP, 2004, JOINTBONESPINE, V71, P550
   53LourensA McCaulM, 2019, PAINRESMANAG, V16
   59VeraE, RELATIONSHIPBETWEENS
   61LiuSS WuCL, 2007, ANESTHANALG, V105
   64TanJY MolassiotisA, 2014, EVIDBASEDCOMPLEMENTA, V2014
   67MelchartD WeidenhammerW StrengA etal, 2004, PROSPECTIVEINVESTIGA
   68WittCM PachD, 2009, FORSCHKOMPLEMENTMED, V16, P91
   ABBATE D, 1980, LANCET, V2, P1309
   ALTMAN DG, 1990, LANCET, V335, P149, DOI 10.1016/0140-6736(90)90014-V
   [Anonymous], 2015, CLINJPAIN, V31
   [Anonymous], 2008, MINERVAANESTESIOL, V74, P353
   [Anonymous], EVID COMPLEMENT ALTE
   [Anonymous], MINERVAANESTESIOL
   [Anonymous], 2010, JEVIDBASEDMED, V3, P140
   Boutron I, 2008, ANN INTERN MED, V148, P295, DOI 10.7326/0003-4819-148-4-200802190-00008
   Breivik H, 2008, BRIT J ANAESTH, V101, P17, DOI 10.1093/bja/aen103
   Chan MTV, 2008, ANESTH ANALG, V107, P1189, DOI 10.1213/ane.0b013e318184b94e
   Chung KF, 2014, ACUPUNCT MED, V32, P455, DOI 10.1136/acupmed-2014-010635
   Crew KD, 2006, WORLD J GASTROENTERO, V12, P354, DOI 10.3748/wjg.v12.i3.354
   Cumpston M, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000142
   DanversA, AURICULARACUPUNCTURE
   Devin CJ, 2015, J CLIN NEUROSCI, V22, P930, DOI 10.1016/j.jocn.2015.01.003
   Emanuel EJ, 2013, LANCET, V381, P1532, DOI 10.1016/S0140-6736(13)60970-8
   Coura LEF, 2011, ACUPUNCT MED, V29, P16, DOI 10.1136/aim.2010.003251
   Fletcher D, 2008, PAIN, V137, P441, DOI 10.1016/j.pain.2008.02.026
   Gaffney CJ, 2017, ORTHOP CLIN N AM, V48, P407, DOI 10.1016/j.ocl.2017.05.001
   Gerbershagen HJ, 2013, ANESTHESIOLOGY, V118, P934, DOI 10.1097/ALN.0b013e31828866b3
   He BJ, 2013, PAIN MED, V14, P1608, DOI 10.1111/pme.12197
   Herrera FJ, 2007, ANESTH ANALG, V105, P63, DOI 10.1213/01.ane.0000265534.73169.95
   Jung KW, 2012, CANCER RES TREAT, V44, P25, DOI 10.4143/crt.2012.44.1.25
   Kehlet H, 2006, LANCET, V367, P1618, DOI 10.1016/S0140-6736(06)68700-X
   Lai ECH, 2014, SURG-J R COLL SURG E, V12, P290, DOI 10.1016/j.surge.2014.02.004
   Lorenz KA, 2009, J AM BOARD FAM MED, V22, P291, DOI 10.3122/jabfm.2009.03.080162
   Meissner W, 2017, DTSCH ARZTEBL INT, V114, P161, DOI 10.3238/arztebl.2017.0161
   Miclescu A, 2017, SCAND J PAIN, V16, P204, DOI 10.1016/j.sjpain.2017.04.072
   Milne AN, 2009, HUM GENET, V126, P615, DOI 10.1007/s00439-009-0722-x
   Mitra S, 2018, CURR PAIN HEADACHE R, V22, DOI 10.1007/s11916-018-0690-8
   Ndubisi C, 2019, CONTRACEPTION, V99, P143, DOI 10.1016/j.contraception.2018.11.016
   Nogier R, 2014, MED ACUPUNCT, V26, P76, DOI 10.1089/acu.2014.1035
   Plunkett A, 2018, PAIN MANAG, V8, P287, DOI 10.2217/pmt-2018-0007
   Romoli M, 2014, NEUROL SCI, V35, pS189, DOI 10.1007/s10072-014-1768-7
   Russo MW, 2017, ORTHOP CLIN N AM, V48, P401, DOI 10.1016/j.ocl.2017.06.006
   Schug SA, 2016, MED J AUSTRALIA, V204, P315, DOI 10.5694/mja16.00133
   ScullionA, PATIENTREPORTSOFADVE
   沈孟育, 1998, 空气动力学学报, V16, P56
   Sovacool BK, 2017, SOC STUD SCI, V47, P703, DOI 10.1177/0306312717709363
   Srikandarajah S, 2011, PAIN, V152, P1734, DOI 10.1016/j.pain.2011.02.008
   StellenbergEL BruceJC, 2007, CHURCHILLLIVINGSTONE
   Todorov A, 2008, ANN NY ACAD SCI, V1124, P208, DOI 10.1196/annals.1440.012
   Xu SY, 2005, SMALL, V1, P1221, DOI 10.1002/smll.200500240
   Yang XY, 2015, BRIT J ANAESTH, V115, P883, DOI 10.1093/bja/aev352
   Yuan QL, 2016, SCI REP-UK, V6, DOI 10.1038/srep30675
   Zhang RX, 2014, ANESTHESIOLOGY, V120, P482, DOI 10.1097/ALN.0000000000000101
NR 66
TC 15
Z9 17
U1 1
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-8307
EI 1878-7541
J9 EXPLORE-NY
JI Explore-J Sci. Heal.
PD JAN-FEB
PY 2022
VL 18
IS 1
BP 36
EP 43
DI 10.1016/j.explore.2021.09.007
EA JAN 2022
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA YG3DB
UT WOS:000742371600008
PM 34642104
DA 2026-01-16
ER

PT J
AU He, LH
   Tan, KP
   Lin, XM
   Yi, H
   Wang, XL
   Zhang, JS
   Lin, JT
   Lin, LZ
AF He, Lihua
   Tan, Keping
   Lin, Xianming
   Yi, Hui
   Wang, Xueliang
   Zhang, Jiangsong
   Lin, Jietao
   Lin, Lizhu
TI Multicenter, randomized, double-blind, controlled trial of
   transcutaneous electrical nerve stimulation for pancreatic cancer
   related pain
SO MEDICINE
LA English
DT Article
DE pain; pancreatic cancer; transcutaneous electrical nerve stimulation
ID OPIOID ANALGESIC REQUIREMENT; LOW-FREQUENCY; ACUPUNCTURE; TENS
AB Background: Up to 80% of patients with pancreatic cancer experience abdominal and back pain. Although pharmacologic medications provide some relief, many report inadequate analgesia and adverse effects. Transcutaneous electrical nerve stimulation (TENS) is a non-invasive physical modality and had been widely applied for pain relieving, yet no study has investigated the effectiveness of TENS for pain in pancreatic cancer. Methods: Eligible patients were randomly assigned in a 1:1 ratio to TENS group or control group. The primary outcome was percentage change of numerous rating scale (NRS) after treatment. Secondary outcomes included percentage change of analgesic medication consumption and effect on constipation and poor appetite. Results: One hundred seventy-one patients were recruited (84 to control group and 87 to TENS group). NRS in TENS group has been largely decreased 77.9% right after treatment and 27.1% in 2 hours, before applying any analgesic medication, while that in control group was slightly downregulated right after treatment but gave a trend to increase at 1, 2, and 3 hours. When comparing both groups, pain was significantly well controlled without analgesic medication supplement in TENS group at 0 hour (difference in mean percent change in NRS = 50.0 [95% CI, 50-51.4], P < .01) and 3 hours (difference in mean percent change in NRS = 134.0 [95% CI, 130.0-142.7], P < .01) after treatment, and this analgesic effect last to 3 weeks after treatment cycle (difference in mean percent change in NRS = 22.5 [95% CI, 17.6-27.3], P < .01) without increase of analgesic medication consumption. Conclusions: TENS reduces pain without increase analgesic medication consumption in patients with pancreatic cancer pain. It provides an alternative therapy for pain in pancreatic cancer.
C1 [He, Lihua] Jinan Univ, Fuda Canc Hosp, Dept Tradit Chinese Med, Jinan, Peoples R China.
   [He, Lihua] Guangzhou Univ Chinese Med, Guangzhou, Peoples R China.
   [He, Lihua; Yi, Hui; Wang, Xueliang] Jinan Univ, Fuda Canc Hosp, Dept Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China.
   [Tan, Keping] Zhejiang Univ Tradit Chinese Med, Dept Acupuncture, Prov Tongde Hosp Zhejiang, Hangzhou, Zhejiang, Peoples R China.
   [Lin, Xianming; Zhang, Jiangsong] Zhejiang Univ Tradit Chinese Med, Dept Acupuncture, Affiliated Hosp 3, Hangzhou, Zhejiang, Peoples R China.
   [Lin, Jietao; Lin, Lizhu] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Oncol, Guangzhou, Guangdong, Peoples R China.
C3 University of Jinan; Guangzhou University of Chinese Medicine; Jinan
   University; Zhejiang Chinese Medical University; Zhejiang Chinese
   Medical University; Guangzhou University of Chinese Medicine
RP Lin, LZ (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Oncol, Guangzhou, Guangdong, Peoples R China.
EM quincyhe@163.com
RI Lin, Jietao/GXF-2015-2022
FU Guangdong provincial administration of traditional Chinese medicine
   [20162040]; National Clinical Key Specialty [ZX001232]
FX This study is supported by Guangdong provincial administration of
   traditional Chinese medicine (20162040) and National Clinical Key
   Specialty (ZX001232).
CR Arcidiacono PG, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007519.pub2
   Beck SL, 2010, J PAIN SYMPTOM MANAG, V39, P100, DOI 10.1016/j.jpainsymman.2009.06.009
   Bennett MI, 2010, J PAIN, V11, P351, DOI 10.1016/j.jpain.2009.08.002
   Bergeron-Vézina K, 2015, PAIN, V156, P2093, DOI 10.1097/j.pain.0000000000000276
   Chen AP, 2012, J AM ACAD DERMATOL, V67, P1025, DOI 10.1016/j.jaad.2012.02.010
   Chen L, 1998, ANESTH ANALG, V87, P1129, DOI 10.1097/00000539-199811000-00028
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Gibson W, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011976.pub2
   Guo Y., 2015, SHANGHAI J ACUPUNCT, V5, P464
   Hamza MA, 1999, ANESTHESIOLOGY, V91, P1232, DOI 10.1097/00000542-199911000-00012
   HAN JS, 1991, PAIN, V47, P295, DOI 10.1016/0304-3959(91)90218-M
   Hurlow A, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006276.pub3
   Inoue T, 2003, J NEUROL SCI, V211, P43, DOI 10.1016/S0022-510X(03)00038-8
   JEFFREY L, 2015, PAIN MED, V16, P1204, DOI DOI 10.1111/pme.12038
   Johnson MI, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006142.pub3
   Kuai Le, 2012, Zhongguo Zhen Jiu, V32, P331
   LEEM JW, 1995, NEUROSCI LETT, V192, P197, DOI 10.1016/0304-3940(95)11644-C
   Lisi TL, 2006, J NEUROSCI METH, V150, P74, DOI 10.1016/j.jneumeth.2005.06.001
   Lisón JF, 2017, OBSTET GYNECOL, V129, P363, DOI 10.1097/AOG.0000000000001842
   Maedai Y, 2007, BRAIN RES, V1136, P43, DOI 10.1016/j.brainres.2006.11.061
   Meng FF, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000013736
   Nagels W, 2013, PAIN MED, V14, P1140, DOI 10.1111/pme.12176
   Network, 2018, OPIOID PRINCIPLES PR, P7
   Rakel BA, 2014, PAIN, V155, P2599, DOI 10.1016/j.pain.2014.09.025
   Robb K, 2009, J PAIN SYMPTOM MANAG, V37, P746, DOI 10.1016/j.jpainsymman.2008.03.022
   Turk DC, 2006, PAIN, V125, P208, DOI 10.1016/j.pain.2006.09.028
   Zheng YC, 2014, COMPLEMENT THER MED, V22, P724, DOI 10.1016/j.ctim.2014.05.005
NR 27
TC 11
Z9 13
U1 2
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB 5
PY 2021
VL 100
IS 5
AR e23748
DI 10.1097/MD.0000000000023748
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QB6GS
UT WOS:000614237200018
PM 33592831
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ben-Arye, E
   Gressel, O
   Keshet, Y
   Zaritsky, V
   Kassem, S
   Segev, Y
   Samuels, N
AF Ben-Arye, Eran
   Gressel, Orit
   Keshet, Yael
   Zaritsky, Vika
   Kassem, Sameer
   Segev, Yakir
   Samuels, Noah
TI War and Cancer: Exploring Patient Narratives in a Randomized
   Integrative Oncology Study
SO PSYCHO-ONCOLOGY
LA English
DT Article
DE cancer; integrative medicine; integrative oncology; pain; supportive and
   palliative care; war
ID PROGRAM
AB Study ObjectiveThe current war in Israel has affected quality of life (QoL)-related concerns among patients with cancer. Integrative oncology (IO) provides complementary medicine within supportive and palliative care. The study examined an IO program in northern Israel for cancer and war-related concerns.MethodsThis qualitative study, nested within a prospective randomized controlled trial, examined patients undergoing oncology and palliative care expressing cancer and war-related QoL concerns referred by oncology healthcare providers to an IO program. Patients were randomized to manual-relaxation with (Group A) or without (Group B) acupuncture. Narratives were recorded in MYCaW (Measure Yourself Concerns and Well-being) questionnaires immediately and after 24 h. Narrative excerpts were qualitatively analyzed using ATLAS.Ti software for systematic coding.ResultsPatient narratives (Group A, 67; Group B, 58) focused primarily on themes which included a sense of calmness and reduced emotional distress (e.g., stress, anxiety, worries, nervousness), more prominently in Group B (manual-relaxation only; 55/56 immediately/after 24 h); and reduced pain severity, more so in Group A (with acupuncture; 19/24). Most excerpts described improved QoL in both groups (142/147, 97%) immediately after IO treatments, less so at 24 h (103/135).ConclusionsNarratives of patients facing cancer- and war-related QoL challenges due to the ongoing war in Israel describe a beneficial impact of IO treatments, both immediately and after 24 h. Manual-relaxation without acupuncture was more likely to improve emotional concerns, with pain relief more apparent with the addition of acupuncture. Further qualitative and quantitative research is needed to explore these findings.
C1 [Ben-Arye, Eran; Gressel, Orit] Clalit Hlth Serv, Integrat Oncol Program, Oncol Serv, Haifa, Israel.
   [Ben-Arye, Eran; Gressel, Orit] Clalit Hlth Serv, Lin Carmel & Zebulun Med Ctr, Haifa, Israel.
   [Ben-Arye, Eran; Gressel, Orit; Zaritsky, Vika; Kassem, Sameer] Technion Israel Inst Technol, Ruth & Bruch Rappaport Fac Med, Haifa, Israel.
   [Keshet, Yael] Western Galilee Acad Coll, Dept Sociol, Akko, Israel.
   [Kassem, Sameer] Lady Davis Carmel Med Ctr, Dept Internal Med, Haifa, Israel.
   [Segev, Yakir] Carmel Hosp, Dept Obstet & Gynecol, Unit Gynecol Oncol, Haifa, Israel.
   [Samuels, Noah] Hebrew Univ Jerusalem, Ctr Integrat Complementary Med, Shaare Zedek Med Ctr, Jerusalem, Israel.
C3 Clalit Health Services; Clalit Health Services; Technion Israel
   Institute of Technology; Western Galilee Academic College; Clalit Health
   Services; Carmel Medical Center; Clalit Health Services; Carmel Medical
   Center; Hebrew University of Jerusalem; Shaare Zedek Medical Center
RP Ben-Arye, E (corresponding author), Clalit Hlth Serv, Integrat Oncol Program, Oncol Serv, Haifa, Israel.; Ben-Arye, E (corresponding author), Clalit Hlth Serv, Lin Carmel & Zebulun Med Ctr, Haifa, Israel.; Ben-Arye, E (corresponding author), Technion Israel Inst Technol, Ruth & Bruch Rappaport Fac Med, Haifa, Israel.
EM eranben@technion.ac.il
RI Kassem, Sameer/HNP-6978-2023
FU Israel Cancer Association
FX We are grateful to the integrative medicine teams at the Lin, Zebulun
   and Carmel medical centers: Galit Galil, Dafna Wolf, Avigail Sagi, Olga
   Agour, Reut Keini, Dr. Erez Baruch, Dr. Yulia Bronstein, and Dr. Miri
   Golan.
CR Ben-Arye E, 2023, INT J GYNECOL CANCER, V33, P792, DOI 10.1136/ijgc-2022-004004
   Ben-Arye E, 2012, PATIENT EDUC COUNS, V89, P423, DOI 10.1016/j.pec.2012.02.011
   Bower JE, 2024, J CLIN ONCOL, V42, DOI 10.1200/JCO.24.00541
   Budd S, 2023, MED ACUPUNCT, V35, P159, DOI 10.1089/acu.2023.0012
   Carlson LE, 2023, J CLIN ONCOL, V41, P4562, DOI 10.1200/JCO.23.00857
   Hommerberg C, 2020, BMC PALLIAT CARE, V19, DOI 10.1186/s12904-020-00557-6
   Hovhannisyan A, 2024, PLOS GLOB PUBL HLTH, V4, DOI 10.1371/journal.pgph.0003243
   Keshet Y, 2015, PSYCHO-ONCOLOGY, V24, P169, DOI 10.1002/pon.3621
   Knoerl R, 2021, SUPPORT CARE CANCER, V29, P4191, DOI 10.1007/s00520-021-06174-0
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Marzouk M, 2024, SOC SCI MED, V361, DOI 10.1016/j.socscimed.2024.117364
   Paterson C, 2007, COMPLEMENT THER MED, V15, P38, DOI 10.1016/j.ctim.2006.03.006
   Peeters R, 2023, MED CARE RES REV, V80, P266, DOI [10.1177/10775587221118156, 10.1111/eva.13711]
   Skelton M, 2017, J GLOB ONCOL, V4, DOI 10.1200/JGO.2016.008193
   Verma R, 2022, CURR ONCOL, V29, P589, DOI 10.3390/curroncol29020053
NR 15
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1057-9249
EI 1099-1611
J9 PSYCHO-ONCOLOGY
JI Psycho-Oncol.
PD MAY 6
PY 2025
VL 34
IS 5
AR e70172
DI 10.1002/pon.70172
PG 6
WC Oncology; Psychology; Psychology, Multidisciplinary; Social Sciences,
   Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Psychology; Biomedical Social Sciences
GA 2FR5U
UT WOS:001481547700001
PM 40326225
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Wang, YN
   Tao, SY
   Yu, ZY
   Luo, Y
   Li, Y
   Tang, J
   Chen, GH
   Shuai, RX
   Hu, XY
   Wu, P
   Lei, W
AF Wang, Yingni
   Tao, Siyu
   Yu, Zeyun
   Luo, Yun
   Li, Yuan
   Tang, Jie
   Chen, Guanhua
   Shuai, Rouxian
   Hu, Xinyue
   Wu, Ping
   Lei, Wei
TI Effect of Moxibustion on β-EP and Dyn Levels of Pain-Related Indicators
   in Patients with Rheumatoid Arthritis
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
AB Background. Rheumatoid arthritis (RA) is a systemic immunodeficiency disease characterized by persistent synovial inflammation, pannus formation, and bone and cartilage destruction, resulting in joint malformations and function decline. Objective. The purpose of this study is to evaluate the effect of moxibustion on clinical symptoms and levels of pain-related indicators beta-endorphin (beta-EP) and dynorphin (Dyn) in patients with RA and to explore the potential anti-inflammatory and analgesic mechanisms of moxibustion in RA treatment. Methods. A total of 64 patients with RA who met the inclusion criteria were randomly and equally classified into the control and treatment groups. The control group received conventional treatment (oral methotrexate, folate, or leflunomide prescribed for a long time). The treatment group was treated with moxibustion at ST36 (Zusanli), BL23 (Shenshu), and Ashi points with respect to the control group. Patients' clinical symptoms and routine inspection indexes (rheumatoid factor [RF], erythrocyte sedimentation rate [ESR], and C-reactive protein [CRP]) were recorded before and after treatment. Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), beta-EP, and Dyn were determined by enzyme-linked immunosorbent assay (ELISA). The software SPSS24.0 was used for statistical analysis. Results. (1) Compared with the pretreatment result, both of the two groups' clinical symptoms and routine inspection indexes (RF, ESR, and CRP) improved (P < 0.05), and the improvement of clinical symptoms in the treatment group outperformed that in the control group (P < 0.05). (2) TNF-alpha and IL-1 beta levels decreased significantly in the treatment group after treatment (P < 0.01), while no significant difference was observed in the control group (P > 0.05). (3) beta-EP and Dyn levels in the treatment group were significantly increased after treatment (P < 0.01, P < 0.01), but the control group showed no significant difference (P > 0.05, P > 0.05). It is worth mentioning that the serum TNF-alpha, IL-1 beta, beta-EP, and Dyn levels between the two groups were significantly different after 8 weeks of treatment (P < 0.05). (4) Differences in the serum beta-EP and Dyn levels in the patients of the treatment group were correlated with TNF-alpha and IL-1 beta levels after treatment, and the correlation was mainly negative (r < 0). Conclusion. Moxibustion can improve joint pain in patients with RA using conventional western medicine. One of the mechanisms may affect the serum beta-EP and Dyn levels by downregulating the inflammatory factors to play an anti-inflammatory and analgesic role.
C1 [Wang, Yingni; Tao, Siyu; Yu, Zeyun; Luo, Yun; Tang, Jie; Chen, Guanhua; Shuai, Rouxian; Hu, Xinyue; Wu, Ping; Lei, Wei] Chengdu Univ Tradit Chinese Med, Chengdu 610075, Sichuan, Peoples R China.
   [Li, Yuan] Hosp Chengdu Univ Tradit Chinese Med, Chengdu 610075, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Wu, P (corresponding author), Chengdu Univ Tradit Chinese Med, Chengdu 610075, Sichuan, Peoples R China.
EM wuping_33@163.com
OI Wu, Ping/0000-0003-4062-9447
FU National Natural Science Foundation of China [81373738]; Education
   Department of Sichuan Province [2017JY0016]
FX The authors thank their colleagues from Chengdu University of TCM and
   Sichuan Province Traditional Chinese Medicine Hospital/Teaching Hospital
   of Chengdu University of TCM, who provided insight and expertise that
   greatly assisted the research. This research was supported by grants
   from the National Natural Science Foundation of China (81373738) and the
   Education Department of Sichuan Province (2017JY0016).
CR Aletaha D, 2010, ARTHRITIS RHEUM-US, V62, P2569, DOI 10.1002/art.27584
   Brennan FM, 2008, J CLIN INVEST, V118, P3537, DOI 10.1172/JCI36389
   Fan Y.P., 2014, STUDY ROLE LOCAL ATP
   Gong YY, 2019, PAIN RES MANAG, V2019, DOI 10.1155/2019/4705247
   HARBUZ MS, 1989, J ENDOCRINOL, V122, P705, DOI 10.1677/joe.0.1220705
   Jiang YL, 2015, EXP THER MED, V9, P2344, DOI 10.3892/etm.2015.2407
   Jin S., 2019, CHIN J BASIC MED TCM, V25, P1404
   Li Y., 2019, Chin. Arch. Tradit. Chin. Med., V37, P142
   Liu Fei, 2006, Zhongguo Zhen Jiu, V26, P436
   Liu HR, 2010, WORLD J GASTROENTERO, V16, P4079, DOI 10.3748/wjg.v16.i32.4079
   Liu Zhidan, 2017, Zhongguo Zhen Jiu, V37, P1083, DOI 10.13703/j.0255-2930.2017.10.015
   Machelska H, 2003, J NEUROIMMUNOL, V141, P30, DOI 10.1016/S0165-5728(03)00213-3
   Mousa SA, 2003, ADV EXP MED BIOL, V521, P77
   Naqvi AA, 2019, J PAK MED ASSOC, V69, P389
   [任继刚 Ren Jigang], 2017, [时珍国医国药, Lishizhen Medicine and Materia Medica Research], V28, P3048
   Rittner HL, 2005, J LEUKOCYTE BIOL, V78, P1215, DOI 10.1189/jlb.0405223
   Sehgal N, 2011, PAIN PHYSICIAN, V14, P249
   Shen BY, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016413
   STEIN C, 1990, P NATL ACAD SCI USA, V87, P5935, DOI 10.1073/pnas.87.15.5935
   STEIN C, 1989, J PHARMACOL EXP THER, V248, P1269
   唐玉芝, 2019, [时珍国医国药, Lishizhen Medicine and Materia Medica Research], V30, P2187
   Wasserman AM, 2011, AM FAM PHYSICIAN, V84, P1245
   Zheng Bao-Zhu, 2013, Zhongguo Zhen Jiu, V33, P433
   Zhu G.F., 2015, WORLD CHINESE MED, V10, P629
   Zhu W.L., 2011, MODERN CHINESE CLIN, V18, P1
NR 25
TC 19
Z9 23
U1 1
U2 22
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD APR 5
PY 2021
VL 2021
AR 6637554
DI 10.1155/2021/6637554
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA RP3AP
UT WOS:000641605000001
PM 33884025
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Huang, W
   Yu, TY
   Long, WF
   Xiao, JB
   Zhao, GF
AF Huang Wei
   Yu Tingyu
   Long Wenfei
   Xiao Jianbin
   Zhao Gaofeng
TI Effect of electrically stimulating acupoint, Zusanli (ST 36), on
   patient's recovery after laparoscopic colorectal cancer resection: a
   randomized controlled trial
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE Colorectal neoplasms; Laparoscopes; Transcutaneous electric nerve
   stimulation; Recovery of function; Randomized controlled trial
ID ENHANCED RECOVERY; SURGERY; ACUPUNCTURE; PAIN; ELECTROACUPUNCTURE;
   MECHANISMS; MANAGEMENT; POSTERIOR; GASES
AB OBJECTIVE: To investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on enhanced recovery after surgery (ERAS) in laparoscopic colorectal cancer resection and its clinical significance.
   METHODS: Sixty-four patients undergoing laparoscopic colorectal resection were randomly divided into two groups, the control group (group A) and the TEAS group (group B). Patients in the TEAS group received electroacupuncture stimulation of bilateral Zusanli (ST 36) at 30 min before anesthesia to the end of surgery. The patients in the control group were not given the stimulation. Perioperative anesthesia management of the two groups were performed according to the ERAS guidelines, and postoperative patient-controlled intravenous analgesia (PCIA) was used. The amount of remifentanil used in the two groups was observed and recorded, and the visual analogue scale (VAS) of the 4, 12, 24 and 48 h after surgery in the two groups was recorded. Moreover, postoperative anal ex-haust time, postoperative feeding time, postoperative first ambulation time and postoperative hospital stay length were compared between the two groups.
   RESULTS: Compared with group A, the VAS score of group B decreased significantly at 48 h after operation (P < 0.05). The postoperative anal exhaust time in group B was significantly shorter than that of group A (P < 0.05). There was no significant difference between the two groups with regards to remifentanil consumption, postoperative feeding time, postoperative first ambulation time and postoperative hospital stay (all P> 0.05).
   CONCLUSION: TEAS can promote the recovery of postoperative gastrointestinal function and reduce the pain intensity 48 h after surgery, thus satisfying the need of early postoperative analgesia. (C) 2019 JTCM. All rights reserved.
C1 [Huang Wei; Long Wenfei; Xiao Jianbin; Zhao Gaofeng] Guangdong Prov Hosp Chinese Med, Dept Anesthesiol, Guangzhou 510000, Guangdong, Peoples R China.
   [Yu Tingyu] Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou 510000, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Zhao, GF (corresponding author), Guangdong Prov Hosp Chinese Med, Dept Anesthesiol, Guangzhou 510000, Guangdong, Peoples R China.
EM zhaogaofeng97@163.com
CR Abdallah FW, 2013, BRIT J ANAESTH, V111, P721, DOI 10.1093/bja/aet214
   Abdikarim I, 2015, WORLD J GASTROENTERO, V21, P13339, DOI 10.3748/wjg.v21.i47.13339
   Deng G, 2013, ANN SURG ONCOL, V20, P1164, DOI 10.1245/s10434-012-2759-7
   Feldman LS, 2015, CAN J ANESTH, V62, P120, DOI 10.1007/s12630-014-0263-1
   Feng XZ, 2016, INT J SURG, V30, P104, DOI 10.1016/j.ijsu.2016.04.042
   Jiang WW, 2015, GENET MOL RES, V14, P16469, DOI 10.4238/2015.December.9.18
   Kehlet H, 2002, AM J SURG, V183, P630, DOI 10.1016/S0002-9610(02)00866-8
   Lin JG, 2008, AM J CHINESE MED, V36, P635, DOI 10.1142/S0192415X08006107
   Liu JS, 2012, AM J PHYSIOL-REG I, V303, pR209, DOI 10.1152/ajpregu.00301.2010
   Park C, 2015, ANAESTHESIA, V70, P434, DOI 10.1111/anae.12933
   Pavlidis T, 2002, Minerva Chir, V57, P17
   Reuben SS, 2007, J BONE JOINT SURG AM, V89A, P1343, DOI 10.2106/JBJS.F.00906
   Song J, 2013, NEUROGASTROENT MOTIL, V25, P807, DOI 10.1111/nmo.12183
   Su YS, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/535742
   Sun K, 2017, CLIN J PAIN, V33, P340, DOI 10.1097/AJP.0000000000000400
   Takahashi T, 2006, J GASTROENTEROL, V41, P408, DOI 10.1007/s00535-006-1773-6
   Vather R, 2014, CLIN EXP PHARMACOL P, V41, P358, DOI 10.1111/1440-1681.12220
   Vather R, 2013, ANZ J SURG, V83, P319, DOI 10.1111/ans.12102
   Wang BG, 1997, ANESTH ANALG, V85, P406, DOI 10.1097/00000539-199708000-00029
   Wildbrett P, 2003, SURG ENDOSC, V17, P78, DOI 10.1007/s00464-002-9015-3
   Xie J, 2017, CHIN J CANCER, V36, DOI 10.1186/s40880-016-0176-1
   Xiong JJ, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003497
   Xiong LZ, 2007, CHINESE MED J-PEKING, V120, P394, DOI 10.1097/00029330-200703010-00009
   Yang CX, 2012, ACUPUNCTURE ELECTRO, V37, P125, DOI 10.3727/036012912X13831831256249
   Yang Q, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-137
   Yang XY, 2015, BRIT J ANAESTH, V115, P883, DOI 10.1093/bja/aev352
   Yang ZK, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/276320
   Yin Xiu-qi, 2013, Zhen Ci Yan Jiu, V38, P431
   Zhang Q, 2014, ANAESTHESIA, V69, P832, DOI 10.1111/anae.12639
NR 29
TC 29
Z9 40
U1 2
U2 30
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD JUN
PY 2019
VL 39
IS 3
BP 433
EP 439
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA IF3OG
UT WOS:000472989500017
PM 32186016
DA 2026-01-16
ER

PT J
AU Zhang, CH
   Ma, ZZ
   Huo, BB
   Lu, YC
   Wu, JJ
   Hua, XY
   Xu, JG
AF Zhang, Chen-hao
   Ma, Zhen-zhen
   Huo, Bei-bei
   Lu, Ye-chen
   Wu, Jia-jia
   Hua, Xu-yun
   Xu, Jian-guang
TI Diffusional plasticity induced by electroacupuncture intervention in rat
   model of peripheral nerve injury
SO JOURNAL OF CLINICAL NEUROSCIENCE
LA English
DT Article
DE Electroacupuncture; Peripheral nerve injury; Radial diffusivity; Brain
   plasticity
ID CATWALK GAIT ANALYSIS; THALAMIC HYPEREXCITABILITY; BRAIN PLASTICITY;
   CENTRAL PAIN; ACUPUNCTURE; STIMULATION; RECOVERY; THERAPY; PATHWAY;
   CANCER
AB Electroacupuncture (EA) is an adjuvant therapy for peripheral nerve injury (PNI). Both peripheral and central alterations contribute to the rehabilitation process. We employed diffusion tensor imaging (DTI) to investigate the diffusion plasticity of afferent and efferent pathways caused by EA in model of peripheral nerve injury and reparation. Twenty-four rats were divided into three groups: normal group, model group and intervention group. Rats of the model group and the intervention group underwent sciatic nerve transection and anastomosis. EA intervention was performed on the intervention group at ST36 and GB-30 for three months. Gait assessment and DTI were conducted at days post-operative (DPO) 30, 60 and 90. We selected corticospinal tract, spinothalamic tract and internal capsule as regions of interest and analyzed diffusion metrics including fractional anisotropy (FA), axial diffusivity (AD) and radial diffusivity (RD). FA values and RD values displayed significant differences or obvious tendency while AD values maintained a stable level. RD values displayed better indicative performance than FA in internal capsule. The intervention group presented significant correlation between RD values and Regularity Index (RI) during the intervention period. The effect of EA on peripheral nerve injury repairing rats appeared to be accelerated recovery process of sensory and motor neural pathway. We proposed that RD was a potential in vivo indicator for structural plasticity caused by EA and PNI. (C) 2019 Elsevier Ltd. All rights reserved.
C1 [Zhang, Chen-hao; Ma, Zhen-zhen; Lu, Ye-chen; Wu, Jia-jia; Xu, Jian-guang] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Ctr Rehabil, Shanghai, Peoples R China.
   [Zhang, Chen-hao; Xu, Jian-guang] Fudan Univ, Huashan Hosp, Dept Hand Surg, Shanghai, Peoples R China.
   [Hua, Xu-yun] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Dept Trauma & Orthoped, Shanghai, Peoples R China.
   [Ma, Zhen-zhen; Huo, Bei-bei; Lu, Ye-chen; Xu, Jian-guang] Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, 1200 Cailun Rd, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Fudan University;
   Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Xu, JG (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, 1200 Cailun Rd, Shanghai, Peoples R China.
EM jianguangxu@fudan.edu.cn
OI Zhang, Chen-hao/0000-0003-0661-6730; lu, ye-chen/0000-0001-9727-753X;
   Hua, Xu-Yun/0000-0002-2935-7551; Xu, Jian-Guang/0000-0002-9091-8151
FU Shanghai Key Laboratory of Peripheral Nerve and Microsurgery
   [17DZ2270500]
FX This work was supported by the Open Project of Shanghai Key Laboratory
   of Peripheral Nerve and Microsurgery grant number 17DZ2270500.
CR Andersson JLR, 2016, NEUROIMAGE, V125, P1063, DOI 10.1016/j.neuroimage.2015.10.019
   Asplund M, 2009, NEUROEPIDEMIOLOGY, V32, P217, DOI 10.1159/000197900
   Bozkurt A, 2008, J NEUROSCI METH, V173, P91, DOI 10.1016/j.jneumeth.2008.05.020
   Chen X, 2015, BRAIN RES, V1601, P64, DOI 10.1016/j.brainres.2015.01.011
   Cropley VL, 2017, AM J PSYCHIAT, V174, P286, DOI 10.1176/appi.ajp.2016.16050610
   Deumens R, 2007, J NEUROSCI METH, V164, P120, DOI 10.1016/j.jneumeth.2007.04.009
   Dhond RP, 2008, PAIN, V136, P407, DOI 10.1016/j.pain.2008.01.011
   Flondell M, 2017, J PLAST SURG HAND SU, V51, P159, DOI 10.1080/2000656X.2016.1205503
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Goswami R, 2016, PAIN, V157, P729, DOI 10.1097/j.pain.0000000000000430
   Hao J, 1995, J Tradit Chin Med, V15, P114
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Jenkinson M, 2012, NEUROIMAGE, V62, P782, DOI 10.1016/j.neuroimage.2011.09.015
   Lee SH, 2013, CNS NEUROSCI THER, V19, P585, DOI 10.1111/cns.12108
   Li P, 1998, CIRCULATION, V97, P1186, DOI 10.1161/01.CIR.97.12.1186
   Liang SX, 2017, J STROKE CEREBROVASC, V26, P1953, DOI 10.1016/j.jstrokecerebrovasdis.2017.06.018
   Lin KL, 2010, J SURG RES, V161, P101, DOI 10.1016/j.jss.2008.10.020
   Ling JM, 2012, BRAIN, V135, P1281, DOI 10.1093/brain/aws073
   Liu SS, 2017, INT SYM QUAL ELECT, P76, DOI 10.1109/ISQED.2017.7918296
   Lu CY, 2017, STROKE, V48, P1682, DOI 10.1161/STROKEAHA.117.016959
   Ma H, 2017, NEURAL PLAST, V2017, DOI 10.1155/2017/5101925
   Maeda Y, 2017, BRAIN, V140, P914, DOI 10.1093/brain/awx015
   Matsumoto-Miyazaki J, 2016, J ALTERN COMPLEM MED, V22, P887, DOI 10.1089/acm.2014.0356
   Miki K, 2000, PAIN, V85, P263, DOI 10.1016/S0304-3959(99)00279-1
   Napadow V, 2013, HUM BRAIN MAPP, V34, P2592, DOI 10.1002/hbm.22091
   Napadow V, 2009, NEUROIMAGE, V47, P1055, DOI 10.1016/j.neuroimage.2009.05.079
   Pallarés V, 2015, COMPUT METH PROG BIO, V121, P66, DOI [10.1016/j.cmpb.2015.05.011, 10.1016/j.cmpb.7015.05.011]
   Papp EA, 2014, NEUROIMAGE, V97, P374, DOI 10.1016/j.neuroimage.2014.04.001
   Ramu J, 2008, EXP NEUROL, V212, P100, DOI 10.1016/j.expneurol.2008.03.018
   Rusanescu G, 2017, J CELL MOL MED, V21, P299, DOI 10.1111/jcmm.12965
   Sullivan R, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17122101
   Tambalo S, 2015, J NEUROSCI, V35, P10088, DOI 10.1523/JNEUROSCI.0540-15.2015
   Taylor KS, 2009, BRAIN, V132, P3122, DOI 10.1093/brain/awp231
   Wang GX, 2008, J NEUROSCI, V28, P11959, DOI 10.1523/JNEUROSCI.3296-08.2008
   Wasner G, 2008, BRAIN, V131, P2387, DOI 10.1093/brain/awn169
   Wu JJ, 2018, BRAIN RES, V1690, P61, DOI 10.1016/j.brainres.2018.04.009
   Wu Jia-Jia, 2018, World Neurosurg, V114, pe267, DOI 10.1016/j.wneu.2018.02.173
   Yang Y, 2017, NEURAL PLAST, V2017, DOI 10.1155/2017/4716792
   Zhang MX, 2018, ACUPUNCT MED, V36, P170, DOI 10.1136/acupmed-2017-011367
   Zhang RX, 2014, ANESTHESIOLOGY, V120, P482, DOI 10.1097/ALN.0000000000000101
   Zhao L, 2017, JAMA INTERN MED, V177, P508, DOI 10.1001/jamainternmed.2016.9378
   Zhao N, 2018, J INTEGR NEUROSCI, V17, P61, DOI 10.31083/JIN-170043
NR 42
TC 11
Z9 14
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0967-5868
EI 1532-2653
J9 J CLIN NEUROSCI
JI J. Clin. Neurosci.
PD NOV
PY 2019
VL 69
BP 250
EP 256
DI 10.1016/j.jocn.2019.08.088
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA JP5SV
UT WOS:000498325100044
PM 31477463
DA 2026-01-16
ER

PT J
AU Chien, TJ
   Liu, CY
   Chang, YF
   Fang, CJ
   Hsu, CH
AF Chien, Tsai-Ju
   Liu, Chia-Yu
   Chang, Yi-Fang
   Fang, Ching-Ju
   Hsu, Chung-Hua
TI Acupuncture for Treating Aromatase Inhibitor-Related Arthralgia in
   Breast Cancer: A Systematic Review and Meta-Analysis
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review
ID GENERAL FACT-G; POSTMENOPAUSAL WOMEN; RANDOMIZED-TRIAL; TAMOXIFEN
   THERAPY; MUSCULOSKELETAL SYMPTOMS; FUNCTIONAL ASSESSMENT; OSTEOARTHRITIS
   INDEX; TENOSYNOVIAL CHANGES; ADJUVANT TREATMENT; WESTERN-ONTARIO
AB Purpose: Acupuncture has been used as a complementary medical treatment for arthralgia and other types of pain. The objective of this review is to assess the effectiveness of acupuncture in the treatment of arthralgia in patients with breast cancer who were treated with aromatase inhibitors (AIs).
   Methods: A literature search was performed, without language restrictions, of 10 databases from their inception through February 2014. The literature reviewed included randomized clinical trials (RCTs) and clinical trials that compared real versus sham acupuncture for the treatment of AI-related musculoskeletal symptoms (AIMSS). The methodologic quality of these trials was assessed by using the modified Jadad Quality Scale. Meta-analytic software (RevMan 5.0) was used to analyze the data.
   Results: Five To compare the effects of real versus sham acupuncture, five RCTs were assessed by meta-analysis and quality analysis. Three of the RCTs reported favorable effects with regard to use of acupuncture in reducing pain and joint-related symptoms, while the other two RCTs did not. The meta-analysis showed trends toward reduced pain and stiffness in patients given acupuncture compared with those who received sham treatment (n=82; pain, mean difference: -2.07 [95% confidence interval (CI), -4.72 to 0.57]; p=0.12; stiffness, mean difference: -86.10 [95% CI, -249.11 to 76.92]; p=0.30), although these differences were not statistically significant.
   Conclusions: Acupuncture has been reported as a safe and promising treatment for AIMSS, but the present analysis indicated that the effects were not statistically significant. Other outcome measurements, such as imaging studies, would be worth including in future studies to further confirm the efficacy of acupuncture in AIMSS.
C1 [Chien, Tsai-Ju; Liu, Chia-Yu; Hsu, Chung-Hua] Natl Yang Ming Univ, Inst Tradit Med, Taipei 11221, Taiwan.
   [Chien, Tsai-Ju] Taipei City Hosp, Div Hematooncol, Branch Zhong Xing, Dept Internal Med, Taipei, Taiwan.
   [Liu, Chia-Yu; Hsu, Chung-Hua] Taipei City Hosp, Branch Linsen & Chinese Med, Taipei, Taiwan.
   [Liu, Chia-Yu; Hsu, Chung-Hua] Taiwan Int Tradit Chinese Med Training Ctr, Taipei, Taiwan.
   [Chang, Yi-Fang] Mackay Mem Hosp, Dept Hematol & Oncol, Taipei, Taiwan.
   [Chang, Yi-Fang] Mackay Mem Hosp, Good Clin Res Ctr, Taipei, Taiwan.
   [Fang, Ching-Ju] Mackay Mem Hosp, Med Lib, Taipei, Taiwan.
C3 National Yang Ming Chiao Tung University; Taipei City Hospital; Taipei
   City Hospital; Mackay Memorial Hospital; Mackay Memorial Hospital;
   Mackay Memorial Hospital
RP Hsu, CH (corresponding author), Natl Yang Ming Univ, Inst Tradit Med, 155 Li Nong St,Sec 2, Taipei 11221, Taiwan.
EM owlherbs@yahoo.com.tw
RI ; Fang, Ching-Ju/B-4221-2009
OI Chien, Tsai Ju/0000-0001-9646-5272; Fang, Ching-Ju/0000-0002-7892-8840
CR [Anonymous], ACUPUNCTURE TREATMEN
   [Anonymous], RANDOMIZED TRIAL ACU
   [Anonymous], ACUPUNCTURE TREATING
   [Anonymous], ACUPUNCTURE REDUCING
   [Anonymous], J CLIN ONCOL
   [Anonymous], COCHRANDE HANDBOOK F
   Bao T, 2011, CANCER RES, V71, DOI 10.1158/0008-5472.SABCS11-P4-12-13
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Baum M, 2002, LANCET, V359, P2131
   Beith JM, 2011, J CLIN ONCOL, V29, DOI 10.1200/jco.2011.29.15_suppl.tps120
   Burstein HJ, 2007, BREAST, V16, P223, DOI 10.1016/j.breast.2007.01.011
   CHEN XH, 1992, EUR J PHARMACOL, V211, P203
   Chumsri S, 2011, J STEROID BIOCHEM, V125, P13, DOI 10.1016/j.jsbmb.2011.02.001
   Coombes RC, 2004, NEW ENGL J MED, V350, P1081, DOI 10.1056/NEJMoa040331
   Crew Katherine D, 2007, J Cancer Surviv, V1, P283, DOI 10.1007/s11764-007-0034-x
   Crew KD, 2007, J CLIN ONCOL, V25, P3877, DOI 10.1200/JCO.2007.10.7573
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Gandek B, 2015, ARTHRIT CARE RES, V67, P216, DOI 10.1002/acr.22415
   Gao Z, 2013, J TRADIT CHIN MED, V33, P1
   Goss PE, 2003, NEW ENGL J MED, V349, P1793, DOI 10.1056/NEJMoa032312
   Goss PE, 2005, JNCI-J NATL CANCER I, V97, P1262, DOI 10.1093/jnci/dji250
   Harada N, 1997, J STEROID BIOCHEM, V61, P175
   Hawker GA, 2011, ARTHRIT CARE RES, V63, pS240, DOI 10.1002/acr.20543
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Henry NL, 2010, CANCER-AM CANCER SOC, V116, P4360, DOI 10.1002/cncr.25385
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Howell A, 2005, LANCET, V365, P60, DOI 10.1016/s0140-6736(04)17666-6
   Jadad AR, 1996, CONTROL CLIN TRIALS, V17, P1, DOI 10.1016/0197-2456(95)00134-4
   Jong MS, 2006, ACUPUNCTURE ELECTRO, V31, P45, DOI 10.3727/036012906815844337
   JORDAN VC, 1995, ANNU REV PHARMACOL, V35, P195, DOI 10.1146/annurev.pharmtox.35.1.195
   Lafferty WE, 2006, AM J MANAG CARE, V12, P397
   Lee EH, 2004, JPN J CLIN ONCOL, V34, P393, DOI 10.1093/jjco/hyh070
   Leeb BF, 2003, RHEUMATOLOGY, V42, P1173, DOI 10.1093/rheumatology/keg319
   Liberati Alessandro, 2009, PLoS Med, V6, pe1000100, DOI 10.1371/journal.pmed.1000100
   Liberati Alessandro, 2009, BMJ-BRIT MED J, V339, pb2700, DOI [10.1136/bmj.b2700, DOI 10.1136/BMJ.B2700]
   Linde K, 2007, PAIN, V128, P264, DOI 10.1016/j.pain.2006.12.006
   Lintermans A, 2013, ANN ONCOL, V24, P350, DOI 10.1093/annonc/mds290
   Liu MH, 2012, BREAST CANCER RES, V14, DOI 10.1186/bcr3137
   Lu WD, 2010, CURR TREAT OPTION ON, V11, P141, DOI 10.1007/s11864-010-0126-0
   Mao JJ, 2009, INTEGR CANCER THER, V8, P123, DOI 10.1177/1534735409332903
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   McDonnell DP, 1999, TRENDS ENDOCRIN MET, V10, P301, DOI 10.1016/S1043-2760(99)00177-0
   McManus Claire A, 2007, Acupunct Med, V25, P36
   Mendoza T, 2006, EUR J PAIN, V10, P353, DOI 10.1016/j.ejpain.2005.06.002
   Moffet HH, 2009, J ALTERN COMPLEM MED, V15, P213, DOI 10.1089/acm.2008.0356
   Morales L, 2008, J CLIN ONCOL, V26, P3147, DOI 10.1200/JCO.2007.15.4005
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Paley CA, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub2
   Partridge AH, 2003, J CLIN ONCOL, V21, P602, DOI 10.1200/JCO.2003.07.071
   Salaffi F, 2003, OSTEOARTHR CARTILAGE, V11, P551, DOI 10.1016/S1063-4584(03)00089-X
   SJOLUND B, 1977, ACTA PHYSIOL SCAND, V100, P382, DOI 10.1111/j.1748-1716.1977.tb05964.x
   Towler P, 2013, SUPPORT CARE CANCER, V21, P2913, DOI 10.1007/s00520-013-1882-8
   VALLADARES LE, 1979, ENDOCRINOLOGY, V105, P431, DOI 10.1210/endo-105-2-431
   Victorson D, 2008, QUAL LIFE RES, V17, P1137, DOI 10.1007/s11136-008-9398-2
   Wu MT, 2002, NEUROIMAGE, V16, P1028, DOI 10.1006/nimg.2002.1145
   Yoo YC, 2011, YONSEI MED J, V52, P1016, DOI 10.3349/ymj.2011.52.6.1016
NR 56
TC 46
Z9 51
U1 0
U2 19
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD MAY 1
PY 2015
VL 21
IS 5
BP 251
EP 260
DI 10.1089/acm.2014.0083
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CH5WA
UT WOS:000354105100001
PM 25915433
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Wang, FJ
   Shi, S
   Wang, YQ
   Wang, K
   Fan, SD
   Zhang, YN
   Feng, CC
   Ju, ZY
AF Wang Feng-jiao
   Shi She
   Wang Yong-qiang
   Wang Ke
   Fan Shen-dong
   Zhang Ya-nan
   Feng Chen-chen
   Ju Zi-yong
TI Protective Mechanism of Electroacupuncture on Peripheral Neurotoxicity
   Induced by Oxaliplatin in Rats
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE electroacupuncture; oxaliplatin; peripheral neuropathy; dorsal root
   ganglion; nuclear factor-erythroid-2-related factor 2
ID CLINICAL-PRACTICE; NEUROPATHIC PAIN; ACUPUNCTURE; ACTIVATION; CANCER;
   TRIAL
AB Objective To study the effect of electroacupuncture (EA) on oxaliplatin-induced peripheral neuropathy (OIPN) in rats. Methods Male Sprague-Dawley rats were equally divided into 3 groups using a random number table: the control group, the OIPN group, and the EA (OIPN + EA) group, with 10 rats in each. The time courses of mechanical, cold sensitivity, and microcirculation blood flow intensity were determined. The morphology of the dorsal root ganglion (DRG) was observed by electron microscopic examination. The protein levels of nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and the transient receptor potential (TRP) protein family in DRGs were assayed by Western blot. Results EA treatment significantly reduced mechanical allodynia and cold allodynia in OIPN rats (P<0.01). Notably, oxaliplatin treatment resulted in impaired microcirculatory blood flow and pathomorphological defects in DRGs (P<0.01). EA treatment increased the microcirculation blood flow and attenuated the pathological changes induced by oxaliplatin (P<0.01). In addition, the expression levels of Nrf2 and HO-1 were down-regulated, and the TRP protein family was over-expressed in the DRGs of OIPN rats (P<0.01). EA increased the expression levels of Nrf2 and HO-1 and decreased the level of TRP protein family in DRG (P<0.05 or P<0.01). Conclusion EA may be a potential alternative therapy for OIPN, and its mechanism may be mainly mediated by restoring the Nrf2/HO-1 signaling pathway.
C1 [Wang Feng-jiao; Shi She; Fan Shen-dong; Ju Zi-yong] Shanghai Univ Tradit Chinese Med, Coll Acumox & Tuina, Shanghai 201203, Peoples R China.
   [Wang Yong-qiang] Shanghai Univ Tradit Chinese Med, Dept Anesthesiol, Shuguang Hosp, Shanghai 200120, Peoples R China.
   [Wang Ke; Zhang Ya-nan; Feng Chen-chen] Shanghai Univ Tradit Chinese Med, Acupuncture Anesthesia Clin Res Inst, Yueyang Hosp Integrated Tradit Chinese & Western, Shanghai 200437, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Shanghai University of Traditional
   Chinese Medicine
RP Ju, ZY (corresponding author), Shanghai Univ Tradit Chinese Med, Coll Acumox & Tuina, Shanghai 201203, Peoples R China.
EM juziyong@hotmail.com
RI Wang, Ke/JXN-9969-2024; 王, 凤娇/ISB-8186-2023
FU National Natural Science Foundation of China [81874506]; Shanghai
   Clinical Research Center for Acupuncture and Moxibustion [20MC1920500]
FX *Supported by the National Natural Science Foundation of China (No.
   81874506) and the Shanghai Clinical Research Center for Acupuncture and
   Moxibustion (No. 20MC1920500)
CR Ali U, 2020, CHIN J INTEGR MED, V26, P643, DOI 10.1007/s11655-019-3175-7
   Benson A III, 2018, J NATL COMPR CANC NE, V16, P874, DOI 10.6004/jnccn.2018.0061
   Boyette-Davis J, 2011, EXP NEUROL, V229, P353, DOI 10.1016/j.expneurol.2011.02.019
   Boyette-Davis J, 2011, PAIN, V152, P308, DOI 10.1016/j.pain.2010.10.030
   Chen ZH, 2020, CHIN J INTEGR MED, V26, P375, DOI 10.1007/s11655-019-3038-2
   Chukyo A, 2018, NEUROPEPTIDES, V67, P95, DOI 10.1016/j.npep.2017.12.002
   Flatters SJL, 2004, PAIN, V109, P150, DOI 10.1016/j.pain.2004.01.029
   Gebremedhn EG, 2018, BMC CANCER, V18, DOI 10.1186/s12885-018-4185-0
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Griffith KA, 2017, J PAIN SYMPTOM MANAG, V54, P701, DOI 10.1016/j.jpainsymman.2017.07.033
   Huang CC, 2021, J CLIN MED, V10, DOI 10.3390/jcm10163694
   Jin YX, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8875433
   Ju ZY, 2013, NEURAL REGEN RES, V8, P2350, DOI 10.3969/j.issn.1673-5374.2013.25.006
   Kang LM, 2021, J NEUROL, V268, P3269, DOI 10.1007/s00415-020-09942-w
   Komirishetty P, 2016, NEUROCHEM RES, V41, P2029, DOI 10.1007/s11064-016-1914-0
   Lee JH, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22168811
   Li YY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235917
   Loprinzi CL, 2020, J CLIN ONCOL, V38, DOI 10.1200/JCO.20.01399
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Molassiotis A, 2021, ACUPUNCT MED, V39, P41, DOI 10.1177/0964528420920285
   Nash J, 2019, ACUPUNCT MED, V37, P3, DOI 10.1136/acupmed-2018-011666
   Pozzi E, 2020, EXP NEUROL, V334, DOI 10.1016/j.expneurol.2020.113458
   Shen Y, 2015, NEUROBIOL DIS, V79, P100, DOI 10.1016/j.nbd.2015.04.012
   Siegelmann-Danieli N, 2020, J ALTERN COMPLEM MED, V26, P758, DOI 10.1089/acm.2020.0060
   Singh R, 2021, EXPERT OPIN THER TAR, V25, P529, DOI 10.1080/14728222.2021.1956464
   Storey DJ, 2010, ANN ONCOL, V21, P1657, DOI 10.1093/annonc/mdp594
   Sun H, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3142732
   Wei GL, 2021, J PERIPHER NERV SYST, V26, P35, DOI 10.1111/jns.12432
   Wu B, 2021, FRONT MOL NEUROSCI, V14, DOI 10.3389/fnmol.2021.690858
   Wu CY, 2015, CRIT CARE, V19, DOI 10.1186/s13054-015-1135-y
   Xiao WH, 2012, NEUROSCIENCE, V203, P194, DOI 10.1016/j.neuroscience.2011.12.023
   Yang Y, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/5347804
   Yang Y, 2018, FREE RADICAL BIO MED, V120, P13, DOI 10.1016/j.freeradbiomed.2018.03.007
   Yu JB, 2013, ANESTH ANALG, V116, P239, DOI 10.1213/ANE.0b013e31826f0a4a
   Zhang HW, 2021, NEUROREPORT, V32, P284, DOI 10.1097/WNR.0000000000001589
   Zhang SQ, 2017, J TRADIT CHIN MED, V37, P179
NR 36
TC 2
Z9 2
U1 2
U2 20
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD SEP
PY 2022
VL 28
IS 9
BP 833
EP 839
DI 10.1007/s11655-022-2896-1
EA JUL 2022
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 3Z1PO
UT WOS:000824866200001
PM 35799085
DA 2026-01-16
ER

PT J
AU Liu, T
   Yu, JN
   Kuang, WC
   Wang, XY
   Ye, J
   Qiu, XJ
   Xi, W
   Zeng, Y
   Zou, HH
   Liu, Y
AF Liu, Tong
   Yu, Jiani
   Kuang, Weichuan
   Wang, Xiaoyin
   Ye, Jiang
   Qiu, Xiaojia
   Xi, Wen
   Zeng, Yao
   Zou, Hanhong
   Liu, Yue
TI Acupuncture for uterine fibroids Protocol for a systematic review of
   randomized controlled trials
SO MEDICINE
LA English
DT Review
DE acupuncture; protocol; systematic review; uterine fibroids
AB Background: Uterine fibroids represent the most common gynecological benign tumors in reproductive females. Acupuncture has been applied as a therapeutic modality in China to treat uterine fibroids. However, currently, few critical systematic reviews regarding the effect of acupuncture on uterine fibroids have been published. Our proposed review aims to evaluate the current evidence on the efficacy of acupuncture for uterine fibroids.
   Methods: A total of 7 databases were searched from their inception to December 2018, including PubMed, Medline, Embase, the Cochrane Central Register of Controlled Trials, the Chinese National Knowledge Infrastructure database, the Chinese Biomedical database, and the Wanfang database. The primary outcomes will be reduction in uterine volume and number of fibroids. Secondary outcomes are pelvic or low- back pain, assessed by Visual Analog Scale ( VAS); Irregular menstrual periods; Low- abdominal pressure symptoms such as frequent or urgent urination, or constipation and adverse events. Data synthesis will be computed by RevManV. 5.3.5 software when a data- analysis is allowed. Methodological quality will be evaluated with the risk of bias according to Cochrane Handbook.
   Results: This study will provide high- quality evidence of acupuncture for uterine fibroids.
   Conclusion: The conclusion of this systematic review will provide evidence to judge whether acupuncture is an effective therapeutic intervention for patients with uterine fibroids.
C1 [Liu, Tong; Kuang, Weichuan; Wang, Xiaoyin; Ye, Jiang; Qiu, Xiaojia; Xi, Wen; Zeng, Yao; Liu, Yue] GuangDong Second Hosp Tradit Chinese Med, Dept Acupuncture & Rehabil, Guangzhou, Guangdong, Peoples R China.
   [Yu, Jiani] Guangdong Prov Hosp Tradit Chinese Med, Dept Rehabil Med, Guangzhou, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine
RP Liu, T; Liu, Y (corresponding author), GuangDong Second Hosp Tradit Chinese Med, Dept Acupuncture & Rehabil, Guangzhou, Guangdong, Peoples R China.
EM liutongmama@163.com; liuyue2288@163.com
FU National Science Foundation for Young Scientists of China [81704179]
FX This work is supported by the National Science Foundation for Young
   Scientists of China (No. 81704179).
CR AAGL Advancing Minimally Invasive, 2012, J MINIM INVAS GYN, V19, P3, DOI 10.1016/j.jmig.2011.09.003
   [Anonymous], 2009, BMJ-BRIT MED J, V6, pe1000097, DOI [DOI 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, DOI 10.1371/JOURNAL.PMED.1000097]
   Balshem H, 2011, J CLIN EPIDEMIOL, V64, P401, DOI 10.1016/j.jclinepi.2010.07.015
   Chabbert-Buffet N, 2014, FERTIL STERIL, V102, P630, DOI 10.1016/j.fertnstert.2014.07.1238
   Donnez J, 2016, HUM REPROD UPDATE, V22, P665, DOI 10.1093/humupd/dmw023
   Friend DR, 2017, DRUG DELIV TRANSL RE, V7, P829, DOI 10.1007/s13346-017-0423-2
   Higgins J, 2011, COCHRANE HDB SYSTEMA
   Jacoby VL, 2014, EUR J OBSTET GYN R B, V182, P220, DOI 10.1016/j.ejogrb.2014.09.004
   Kang HS, 2011, MATURITAS, V68, P346, DOI 10.1016/j.maturitas.2011.02.001
   Liu T, 2017, ALTERN THER HLTH MED
   Rong Z, 2017, PLOS ONE, V12
   Stewart EA, 2001, LANCET, V357, P293, DOI 10.1016/S0140-6736(00)03622-9
   Walker CL, 2005, SCIENCE, V308, P1589, DOI 10.1126/science.1112063
   Wallach EE, 2004, OBSTET GYNECOL, V104, P393, DOI 10.1097/01.AOG.0000136079.62513.39
   Wang Y, 2018, KOREAN J RADIOL, V19, P724, DOI 10.3348/kjr.2018.19.4.724
   Zhang Y, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007221.pub2
NR 16
TC 9
Z9 9
U1 2
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB
PY 2019
VL 98
IS 8
AR e14631
DI 10.1097/MD.0000000000014631
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HQ3SP
UT WOS:000462331100080
PM 30813200
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Hershey, B
AF Hershey, Betsy
TI Integrative Veterinary Oncology Part II - Homeopathy, Acupuncture,
   Manual Therapies, Oxygen Therapies, Energy Work and Phototherapies
SO VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
LA English
DT Article
DE Integrative veterinary oncology; Supportive care veterinary oncology;
   Palliative care veterinary oncology
ID MASSAGE THERAPY; SINGING BOWL; CANCER-PATIENTS; OZONE THERAPY; FATIGUE;
   TRIAL; METAANALYSIS; MEDITATION; PAIN
C1 [Hershey, Betsy] Integrat Vet Oncol, 2501 N 32nd St, Phoenix, AZ 85008 USA.
RP Hershey, B (corresponding author), Integrat Vet Oncol, 2501 N 32nd St, Phoenix, AZ 85008 USA.
EM bhershey32@yahoo.com
CR Aghabati N, 2010, EVID-BASED COMPL ALT, V7, P375, DOI 10.1093/ecam/nen006
   [Anonymous], 2008, Integrating Complementary Medicine into Veterinary Practice
   Anschau F, 2019, LASER MED SCI, V34, P1053, DOI 10.1007/s10103-019-02722-7
   Bagot JL, 2021, SUPPORT CARE CANCER, V29, P5873, DOI 10.1007/s00520-021-06137-5
   Bennett MH, 2005, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD004739.pub2, 10.1002/14651858.CD004712.pub2, 10.1002/14651858.CD004818.pub2, 10.1002/14651858.CD005005.pub2, 10.1002/14651858.CD004954.pub2]
   Bidin L, 2016, EUR J INTEGR MED, V8, P747, DOI 10.1016/j.eujim.2016.06.003
   Boyd C, 2016, PAIN MED, V17, P1553, DOI 10.1093/pm/pnw100
   Chen Xiaowei, 2020, Nan Fang Yi Ke Da Xue Xue Bao, V40, P1488, DOI 10.12122/j.issn.1673-4254.2020.10.15
   Chitapanarux I, 2025, CANCER REP-US, V8, DOI 10.1002/cnr2.70109
   Choi KH, 2017, J ACUPUNCT MERIDIAN, V10, P211, DOI 10.1016/j.jams.2017.04.005
   Choi TY, 2022, CANCERS, V14, DOI 10.3390/cancers14184419
   Ciborowski M, 2012, J PROTEOME RES, V11, P6231, DOI 10.1021/pr3008946
   Clavo B, 2005, J ALTERN COMPLEM MED, V11, P539, DOI 10.1089/acm.2005.11.539
   Clavo B, 2025, INTEGR CANCER THER, V24, DOI 10.1177/15347354241307038
   Clavo B, 2021, PAIN MED, V22, P2138, DOI 10.1093/pm/pnaa459
   Clavo B, 2013, J PAIN SYMPTOM MANAG, V46, P106, DOI 10.1016/j.jpainsymman.2012.06.017
   Cole JS, 2024, GLOB ADV INTEGR MED, V13, DOI 10.1177/27536130241245099
   Collinge W, 2013, SUPPORT CARE CANCER, V21, P1405, DOI 10.1007/s00520-012-1682-6
   Di Fede O, 2022, J CLIN MED, V11, DOI 10.3390/jcm11185307
   Evans Ronald C, 2005, Semin Oncol Nurs, V21, P184, DOI 10.1016/j.soncn.2005.04.007
   Frass M, 2020, ONCOLOGIST, V25, pE1930, DOI 10.1002/onco.13548
   Freitas KABDS, 2020, Revista Nursing, V23, P4975
   Freitas KABD, 2021, REV ESC ENFERM USP, V55, DOI [10.1590/1980-220X-REEUSP-2020-0527, 10.1590/1980-220x-reeusp-2020-0527]
   Frenkel M, 2015, CURR ONCOL REP, V17, DOI 10.1007/s11912-015-0467-8
   Goldsby TL, 2017, J EVID-BASED INTEGR, V22, P401, DOI 10.1177/2156587216668109
   Grognet J., 2014, Journal of the American Holistic Veterinary Medical Association, V35, P28
   Heudel PE, 2019, SUPPORT CARE CANCER, V27, P1879, DOI 10.1007/s00520-018-4449-x
   Izzotti A, 2022, CANCERS, V14, DOI 10.3390/cancers14051174
   Jiang Y, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000028860
   Johnston MF, 2007, INTEGR CANCER THER, V6, P36, DOI 10.1177/1534735406298903
   Jonas WB, 2006, INTEGR CANCER THER, V5, P343, DOI 10.1177/1534735406294225
   Kassab S, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004845.pub2
   Kawasoe Y, 2009, ONCOL REP, V22, P1045, DOI 10.3892/or_00000534
   Kilmartin L, 2020, LASER MED SCI, V35, P95, DOI 10.1007/s10103-019-02798-1
   Kinkead B, 2018, CANCER-AM CANCER SOC, V124, P546, DOI 10.1002/cncr.31064
   Lana SE, 2006, J AM ANIM HOSP ASSOC, V42, P361, DOI 10.5326/0420361
   Landry JM, 2014, AM J HEALTH PROMOT, V28, P306, DOI 10.4278/ajhp.121031-ARB-528
   Laoudikou Maria Tsampika, 2020, J Can Chiropr Assoc, V64, P32
   Lee SH, 2015, INTEGR CANCER THER, V14, P297, DOI 10.1177/1534735415572885
   Li YC, 2024, INTEGR CANCER THER, V23, DOI 10.1177/15347354241226667
   Martin R., 2003, PRACTICAL PAIN MANAG, V3, P20
   Matourypour P, 2016, J Nurs Midwifery Res, V21, P255
   Ni XX, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420980825
   Nwabudike LC, 2019, HOMEOPATHY, V108, P277, DOI 10.1055/s-0039-1687822
   Paglioni MD, 2019, ORAL ONCOL, V93, P21, DOI 10.1016/j.oraloncology.2019.04.004
   Paley CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub3
   Rio-Alamos C, 2023, EUR J INVEST HEALTH, V13, P317, DOI 10.3390/ejihpe13020024
   Ripamonti CI, 2012, J BONE ONCOL, V1, P81, DOI 10.1016/j.jbo.2012.08.001
   Ripamonti CI, 2011, ORAL ONCOL, V47, P185, DOI 10.1016/j.oraloncology.2011.01.002
   Robijns J, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.927685
   Rose WJ, 2017, ANIM HEALTH RES REV, V18, P177, DOI 10.1017/S1466252317000068
   Rostock M, 2011, BMC CANCER, V11, DOI 10.1186/1471-2407-11-19
   Saha S, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-230
   Samadder A, 2013, J ACUPUNCT MERIDIAN, V6, P180
   Samuel SR, 2021, J CANCER SURVIV, V15, P799, DOI 10.1007/s11764-020-00972-x
   Schlappack O, 2004, Homeopathy, V93, P210, DOI 10.1016/j.homp.2004.06.004
   Serra-Añó P, 2019, SUPPORT CARE CANCER, V27, P2633, DOI 10.1007/s00520-018-4544-z
   Silva LP, 2024, ANTIOXIDANTS-BASEL, V13, DOI 10.3390/antiox13060673
   Sorrentino L, 2017, J INTERCULT ETHNOPHA, V6, P1, DOI 10.5455/jice.20161229055245
   Tirelli U, 2023, EUR REV MED PHARMACO, V27, P11643, DOI 10.26355/eurrev_202312_34602
   Tirelli U, 2018, EUR REV MED PHARMACO, V22, P8030, DOI 10.26355/eurrev_201811_16432
   Tsang KL, 2007, INTEGR CANCER THER, V6, P25, DOI 10.1177/1534735406298986
   Wang T, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/9967574
   Wang Y, 2023, JAMA SURG, V158, P20, DOI 10.1001/jamasurg.2022.5674
   Yan ZB, 2022, FRONT PAIN RES, V3, DOI 10.3389/fpain.2022.925013
   Zhang YY, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000033939
NR 66
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0195-5616
EI 1878-1306
J9 VET CLIN N AM-SMALL
JI Vet. Clin. N. Am.-Small Anim. Pract.
PD NOV
PY 2025
VL 55
IS 6
BP 1177
EP 1191
DI 10.1016/j.cvsm.2025.07.004
EA OCT 2025
PG 15
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 9NQ5Y
UT WOS:001610670500015
PM 40883158
DA 2026-01-16
ER

PT J
AU Giron, PS
   Haddad, CAS
   Rizzi, SKLD
   Nazário, ACP
   Facina, G
AF Giron, Patricia Santolia
   Simao Haddad, Cinira Assad
   Lopes de Almeida Rizzi, Samantha Karlla
   Pinto Nazario, Afonso Celso
   Facina, Gil
TI Effectiveness of acupuncture in rehabilitation of physical and
   functional disorders of women undergoing breast cancer surgery
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Breast cancer; Rehabilitation; Acupuncture; Depression; Upper limb
   function
ID LYMPHEDEMA; SHOULDER; SAFETY; TRIAL
AB Purpose The purpose of the study is to verify the effectiveness of acupuncture in rehabilitation of physical and functional disorders of women undergoing breast cancer surgery on the following parameters: pain, range of motion, upper limb function, and depressive symptoms.
   Methods The following are the inclusion criteria: women aged more than 18 years with scapular girdle and upper limb pain after 3 months of surgery and with pain a parts per thousand yen3 in visual analog scale. Patients were divided into two randomized groups which received weekly treatment during 10 sessions. Kinesiotherapy group (G1)-treated with a predefined kinesiotherapy protocol of 30 min. Group Acupuncture + Kinesiotherapy (G2)-treated with the same kinesiotherapy group protocol followed by another 30 min of acupuncture, used in predefined points. Both groups performed physical examination and answered the upper limb function and depressive symptoms questionnaires.
   Results Forty-eight patients completed the treatment, 24 in each group. Regarding the pain, the two groups had statistically significant improvement in all evaluated moments. In the analysis of depression, it improved significantly only in G1 in the comparison between the first and the tenth session. The upper limb function had improvement in G1 only in the comparison between the first and the tenth session and in G2, in the three evaluation moments. The range of motion (ROM) showed improvement in all evaluated movements.
   Conclusions There was no difference between groups. Both groups showed statistically significant improvement of the items assessed: pain, depression, upper limb function, and ADM, and there was no difference between them.
C1 [Giron, Patricia Santolia] Rua Marselhesa,249 Vila Mariana, BR-04020060 Sao Paulo, SP, Brazil.
   [Simao Haddad, Cinira Assad; Lopes de Almeida Rizzi, Samantha Karlla; Pinto Nazario, Afonso Celso; Facina, Gil] Univ Fed Sao Paulo, Dept Gynecol, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Giron, PS (corresponding author), Rua Marselhesa,249 Vila Mariana, BR-04020060 Sao Paulo, SP, Brazil.
EM patysantolia@hotmail.com
RI FACINA, GIL/M-6453-2014; Lopes de Almeida Rizzi, Samantha
   Karlla/AAH-2389-2020; nazario, afonso/AHA-5340-2022
OI FACINA, GIL/0000-0003-1418-0295; Santolia, Patricia/0000-0002-1074-1975;
   Lopes de Almeida Rizzi, Samantha Karlla/0000-0002-5969-9499; nazario,
   afonso/0000-0002-0601-4388
CR Ahmed RL, 2006, J CLIN ONCOL, V24, P2765, DOI 10.1200/JCO.2005.03.6749
   Alem M, 2008, ACUPUNCT MED, V26, P86, DOI 10.1136/aim.26.2.86
   Barros ACSD, 2002, PROJETO DIRECTRIZES, V2
   Bregagnol R.K., 2010, Revista Brasileira de Cancerologia, V56, P25, DOI [10.32635/2176-9745.rbc.2010v56n1.1523, DOI 10.32635/2176-9745.RBC.2010V56N1.1523]
   Camargo M.C., 2000, Reabilitacao Fisica no Cancer de Mama
   Cassileth BR, 2013, CANCER-AM CANCER SOC, V119, P2455, DOI 10.1002/cncr.28093
   Couceiro Tania Cursino de Menezes, 2009, Rev. Bras. Anestesiol., V59, P358
   Ernst E, 2001, AM J MED, V110, P481, DOI 10.1016/S0002-9343(01)00651-9
   Fann JR, 2008, GEN HOSP PSYCHIAT, V30, P112, DOI 10.1016/j.genhosppsych.2007.10.008
   Gorenstein C., 1998, REV PSIQUIATRIA CLIN, V25, P245
   Gutierrez MGR, 2007, ACTA PAUL ENFERM, V20, P249, DOI [10.1590/S0103-21002007000300002, DOI 10.1590/S0103-21002007000300002]
   Harrington S, 2011, J CANCER SURVIV, V5, P167, DOI 10.1007/s11764-010-0168-0
   He J. P., 1999, Clinical and Experimental Obstetrics and Gynecology, V26, P81
   Instituto Nacional de Cancer (Brasil), 2013, EST 2014
   MacPherson H, 2010, ACUPUNCT MED, V28, P83, DOI 10.1136/aim.2009.001370
   Mao-Liang Q., 1993, Chinese acupuncture and moxibustion
   Meirelles MCCC, 2006, Braz. J. Phys. Ther., V10, P393
   Oliveira MMF, 2009, BRAZ J PHYS THER, V13, P136, DOI 10.1590/S1413-35552009005000017
   Orfale AG, 2005, BRAZ J MED BIOL RES, V38, P293, DOI 10.1590/S0100-879X2005000200018
   Panobianco M S., 2012, Rev. Eletr. Enf, V14, P532
   Rett Mariana Tirolli, 2012, Rev. dor, V13, P201
   Rostkowska E, 2006, Adv Med Sci, V51, P287
   Haddad CAS, 2013, EINSTEIN-SAO PAULO, V11, P426, DOI 10.1590/S1679-45082013000400004
   Vincent C, 2001, BRIT MED J, V323, P467, DOI 10.1136/bmj.323.7311.467
   Voogd AC, 2003, BRIT J SURG, V90, P76, DOI 10.1002/bjs.4010
NR 25
TC 14
Z9 18
U1 0
U2 32
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JUN
PY 2016
VL 24
IS 6
BP 2491
EP 2496
DI 10.1007/s00520-015-3054-5
PG 6
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA DK5TL
UT WOS:000374983300013
PM 26670916
DA 2026-01-16
ER

PT J
AU Zhi, WI
   Baser, RE
   Talukder, D
   Mei, YZ
   Harte, SE
   Bao, T
AF Zhi, W. Iris
   Baser, Raymond E.
   Talukder, Dristi
   Mei, Ying Zi
   Harte, Steven E.
   Bao, Ting
TI Mechanistic and thermal characterization of acupuncture for
   chemotherapy-induced peripheral neuropathy as measured by quantitative
   sensory testing
SO BREAST CANCER RESEARCH AND TREATMENT
LA English
DT Article
DE Acupuncture; Chemotherapy; Neuropathy; Breast cancer; Sensory loss;
   Quantitative sensory testing
ID PAIN SENSITIVITY; PRESSURE PAIN; RISK-FACTORS; PREVALENCE; SURVIVORS;
   DOMAINS; WOMEN
AB PurposeChemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of chemotherapy. Acupuncture is a promising non-pharmacological intervention for CIPN. However, the physiological effects of acupuncture treatment remain poorly understood. We examined the effects of acupuncture on CIPN using semi-objective quantitative sensory testing (QST). MethodsWe conducted a randomized controlled trial of real acupuncture (RA) and sham acupuncture (SA) compared to usual care (UC) in cancer survivors with moderate-to-severe CIPN. Treatment response was assessed with QST measures of tactile and vibration detection thresholds in hands and feet, thermal detection, and pain thresholds at weeks 0, 8, and 12. Constrained linear mixed model (cLMM) regression was used for statistical analysis. Results63 patients completed QST testing. At week 8, vibrational detection thresholds in feet were significantly lower in RA and SA (p = 0.019 and p = 0.046) than in UC, with no difference between RA and SA (p = 0.637). Both RA and SA also showed significantly higher cool thermal detection than UC (p = 0.008 and p = 0.013, respectively), with no difference between RA and SA (p = 0.790). No differences in tactile detection, vibrational detection in hands, warm thermal detection, and thermal pain thresholds were detected among the three arms at weeks 8 and 12. ConclusionQST demonstrated different patterns in RA, SA, and UC. After eight weeks of RA, we observed significant improvements in the vibrational detection threshold in feet and cool thermal detection threshold in hands compared to UC. No significant differences were seen when compared to SA.
C1 [Zhi, W. Iris] Mem Sloan Kettering Canc Ctr, Dept Med, Breast Med Serv, Solid Tumor Div, New York, NY USA.
   [Baser, Raymond E.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, Dept Med, New York, NY USA.
   [Talukder, Dristi; Bao, Ting] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, New York, NY 10065 USA.
   [Mei, Ying Zi] Columbia Univ, Barnard Coll, New York, NY USA.
   [Harte, Steven E.] Univ Michigan, Med Sch, Chron Pain & Fatigue Res Ctr, Dept Anesthesiol, Ann Arbor, MI USA.
   [Bao, Ting] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 East 61st St, Room 458, New York, NY 10065 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center; Columbia University;
   University of Michigan System; University of Michigan; Memorial Sloan
   Kettering Cancer Center
RP Bao, T (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, New York, NY 10065 USA.; Bao, T (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 East 61st St, Room 458, New York, NY 10065 USA.
EM baot@mskcc.org
RI Harte, Steven/P-4840-2019
OI Bao, Ting/0000-0003-4437-2597; Mei, Ying Zi/0000-0002-1210-3096;
   DESPRES, OLIVIER/0000-0002-2035-4442
FU National Institutes of Health/National Cancer Institute Cancer Center
   Support Grant; Translational and Integrative Medicine Research Fund at
   Memorial Sloan Kettering Cancer Center [P30 CA008748]; Frueauff
   Foundation; National Cancer Institute; Gateway for Cancer Research
   [R37CA248563, R01CA240417, R01CA251470];  [G-22-1200]; National Cancer
   Institute [R01CA240417, R01CA251470, P30CA008748, R37CA248563] Funding
   Source: NIH RePORTER
FX This work was supported in part by the National Institutes of
   Health/National Cancer Institute Cancer Center Support Grant (grant
   number P30 CA008748), the Translational and Integrative Medicine
   Research Fund at Memorial Sloan Kettering Cancer Center, and the
   Frueauff Foundation. The funding sources were not involved in the study
   design; collection, analysis, and interpretation of the data; writing of
   the report; or decision to submit the article for publication. Ting Bao
   is supported by the National Cancer Institute (grant numbers
   R37CA248563, R01CA240417, R01CA251470). W. Iris Zhi is supported by the
   Gateway for Cancer Research (grant number G-22-1200).
CR As-Sanie S, 2013, OBSTET GYNECOL, V122, P1047, DOI 10.1097/AOG.0b013e3182a7e1f5
   Backonja M, 2013, PAIN, V154, P1807, DOI 10.1016/j.pain.2013.05.047
   Bao T, 2021, ONCOLOGIST, V26, pE2070, DOI 10.1002/onco.13933
   Bao T, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.0681
   Bao T, 2016, BREAST CANCER RES TR, V159, P327, DOI 10.1007/s10549-016-3939-0
   Baron R, 2017, PAIN, V158, P261, DOI 10.1097/j.pain.0000000000000753
   Bates D, 2015, J STAT SOFTW, V67, P1, DOI 10.18637/jss.v067.i01
   Cata JP, 2007, J PAIN, V8, P296, DOI 10.1016/j.jpain.2006.09.014
   D'Alessandro EG, 2022, BMJ SUPPORT PALLIAT, V12, P64, DOI 10.1136/bmjspcare-2018-001542
   Drobek W, 2001, Clin Oral Investig, V5, P185
   Edwards RR, 2005, PAIN, V114, P315, DOI 10.1016/j.pain.2005.01.007
   Ewertz M, 2015, ACTA ONCOL, V54, P587, DOI 10.3109/0284186X.2014.995775
   Giesbrecht RJS, 2005, PHYS THER, V85, P1085, DOI 10.1093/ptj/85.10.1085
   Giesecke T, 2004, ARTHRITIS RHEUM-US, V50, P613, DOI 10.1002/art.20063
   Greenspan JD, 2011, J PAIN, V12, pT61, DOI 10.1016/j.jpain.2011.08.006
   Hanai A, 2018, JNCI-J NATL CANCER I, V110, DOI 10.1093/jnci/djx178
   Harte SE, 2019, PAIN, V160, P1270, DOI 10.1097/j.pain.0000000000001505
   Hershman DL, 2014, J ONCOL PRACT, V10, pE421, DOI 10.1200/JOP.2014.001776
   Hershman DL, 2011, BREAST CANCER RES TR, V125, P767, DOI 10.1007/s10549-010-1278-0
   Kenward MG, 2010, STAT MED, V29, P1455, DOI 10.1002/sim.3868
   Kleinböhl D, 1999, PAIN, V81, P35, DOI 10.1016/S0304-3959(98)00266-8
   Lenth RV, 2021, R PACKAGE VERSION 1
   Lin D, 2014, INT J MOL SCI, V15, P3234, DOI 10.3390/ijms15023234
   LU GW, 1983, AM J PHYSIOL, V245, pR606, DOI 10.1152/ajpregu.1983.245.4.R606
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Naliboff BD, 1997, GUT, V41, P505, DOI 10.1136/gut.41.4.505
   Petzke F, 2003, PAIN, V105, P403, DOI 10.1016/S0304-3959(03)00204-5
   Pfau DB, 2012, CURR PAIN HEADACHE R, V16, P199, DOI 10.1007/s11916-012-0261-3
   Puta C, 2012, BMC NEUROL, V12, DOI 10.1186/1471-2377-12-98
   Reed BD, 2017, J LOW GENIT TRACT DI, V21, P78, DOI 10.1097/LGT.0000000000000267
   Rolke R, 2006, EUR J PAIN, V10, P77, DOI 10.1016/j.ejpain.2005.02.003
   Rostock M, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/349653
   Schneider BP, 2015, ADV EXP MED BIOL, V862, P77, DOI 10.1007/978-3-319-16366-6_6
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Staff NP, 2017, ANN NEUROL, V81, P772, DOI 10.1002/ana.24951
   Team RC, 2021, R LANG ENV STAT COMP
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Wong Raimond, 2006, Acupunct Med, V24, P87
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zhi WI, 2021, BREAST CANCER RES TR, V186, P761, DOI 10.1007/s10549-020-06079-2
   Zhi WI, 2019, BREAST CANCER RES TR, V178, P587, DOI 10.1007/s10549-019-05416-4
NR 42
TC 6
Z9 7
U1 1
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0167-6806
EI 1573-7217
J9 BREAST CANCER RES TR
JI Breast Cancer Res. Treat.
PD FEB
PY 2023
VL 197
IS 3
BP 535
EP 545
DI 10.1007/s10549-022-06846-3
EA DEC 2022
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 8K7DE
UT WOS:000900062800001
PM 36527520
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Günes, D
   Karabulutlu, EY
AF Gunes, Demet
   Karabulutlu, Elanur Yilmaz
TI The Effects of Su Jok Therapy on Pain, Fatigue, Insomnia, Nausea, and
   Vomiting Experienced by Patients With Gastrointestinal System Cancer
SO HOLISTIC NURSING PRACTICE
LA English
DT Article
DE fatigue; gastrointestinal system cancer; insomnia; nausea; nursing;
   pain; Su Jok complementary and integrative practice; vomiting
ID CHEMOTHERAPY-INDUCED NAUSEA; SEVERITY INDEX; ACUPRESSURE; COMPLEMENTARY;
   VALIDATION; SCALE
AB Su Jok therapy is used as an energy-based complementary and alternative method in cancer patients. The study was conducted to determine the effects of Su Jok therapy on pain, fatigue, insomnia, nausea, and vomiting experienced by patients with gastrointestinal cancer. This randomized controlled trial was conducted with 48 patients. Data were collected by the researcher by using an introductory information form, the short form McGill pain questionnaire, the cancer fatigue scale, the insomnia severity index, the Rhodes index of nausea, vomiting, and retching, and the visual analog scale. It was found that, after the application of Su Jok seed treatment, there was a significant decrease in the mean scores of the intervention group on the McGill pain scale, the cancer fatigue scale, the insomnia severity index, and the Rhodes index of nausea, vomiting, Su Jok therapy was effective in reducing the pain, fatigue, insomnia, nausea, and vomiting scores of patients with gastrointestinal cancer.
C1 [Gunes, Demet] Erzincan Binali Yildirim Univ, Fac Hlth Sci, Dept Nursing, Erzincan Merkez, TR-24100 Erzincan, Turkiye.
   [Karabulutlu, Elanur Yilmaz] Ataturk Univ, Fac Hlth Sci, Dept Internal Med Nursing, Erzurum, Turkiye.
C3 Erzincan Binali Yildirim University; Ataturk University
RP Günes, D (corresponding author), Erzincan Binali Yildirim Univ, Fac Hlth Sci, Dept Nursing, Erzincan Merkez, TR-24100 Erzincan, Turkiye.
EM demetimm24@gmail.com
RI Güneş, Demet/HKE-3078-2023
CR Admi H, 2017, ONCOL NURS FORUM, V44, P553, DOI 10.1188/17.ONF.553-561
   Akin B., 2021, J Hacettepe Univ Fac Nurs, V8, P117, DOI DOI 10.31125/HUNHEMSIRE.908072
   Arslan M, 2015, TURK ONCOL DERG, V30, P82, DOI 10.5505/tjoncol.2015.1204
   Atalikoglu BS., 2022, Symptom management in oncology nursing, P159
   Aydemir T., 2018, The effect of acupressure on pain, physical function and quality of life in individuals with knee osteoarthritis
   Bahar A, 2019, V6, P42
   Bastien CH, 2001, SLEEP MED, V2, P297, DOI 10.1016/S1389-9457(00)00065-4
   Bean HR, 2022, SLEEP, V45, DOI 10.1093/sleep/zsab246
   Bicici B., 2010, Reliability and validity of the Turkish version short-form McGill pain questionnaire
   Boysan M, 2010, ANADOLU PSIKIYATR DE, V11, P248
   Buyukbayram Z, 2021, EXPLORE-NY, V17, P22, DOI 10.1016/j.explore.2020.07.009
   Buyukozturk S., 2020, The handbook of data analysis for social sciences, DOI [10.14527/9789756802748, DOI 10.14527/9789756802748]
   Chen YW, 2014, PAIN MANAG NURS, V15, P539, DOI 10.1016/j.pmn.2012.12.005
   Choi TY, 2017, INTEGR CANCER THER, V16, P135, DOI 10.1177/1534735416664172
   Vu DV, 2017, COMPLEMENT THER CLIN, V29, P111, DOI 10.1016/j.ctcp.2017.09.005
   Dikmen HA, 2019, PAIN MANAG NURS, V20, P47, DOI 10.1016/j.pmn.2018.03.001
   Şimşek HE, 2020, Journal of Traditional Medical Complementary Therapies, V3, P265, DOI [10.5336/jtracom.2019-72803, 10.5336/jtracom.2019-72803, DOI 10.5336/JTRACOM.2019-72803]
   Ertürk NE, 2021, COMPLEMENT THER MED, V56, DOI 10.1016/j.ctim.2020.102587
   Genç F, 2015, PALLIAT SUPPORT CARE, V13, P275, DOI 10.1017/S1478951514000248
   Gjuzeleva T, 2019, Knowledge-International J, V30, P1011
   Goktas S., 2023, J Clin Med Kazakhstan, V20, P17, DOI DOI 10.23950/JCMK/13691
   Guyton K, 2019, CANCER: PREVENTION, EARLY DETECTION, TREATMENT AND RECOVERY, 2ND EDITION, P259
   Hajbaghery MA, 2018, Journal of Complementary Medicine & Alternative Healthcare, V5, DOI [10.19080/jcmah.2018.05.555666, 10.19080/JCMAH.2018.05.555666]
   Han CJ, 2019, J PAIN SYMPTOM MANAG, V58, P224, DOI 10.1016/j.jpainsymman.2019.04.035
   Hassanpour SH, 2017, Journal of Cancer Research and Practice, V4, P127, DOI [10.1016/j.jcrpr.2017.07.001, DOI 10.1016/J.JCRPR.2017.07.001, 10.1016/j. jcrpr.2017.07.001, 10.1016/j.jcrpr.2017.07.001]
   Huber JCOT, 2016, MediSan, V20, P5009
   Ivanov P., 2018, Su Jok and Moxa. A Self-Treat a Self-Treatment Manual
   Kahraman A, 2022, COMPLEMENT MED RES, V29, P402, DOI 10.1159/000526903
   Karakus Z., 2022, Ournal Hacettepe Univ Fac Nurs, V9, P64
   Kocatakan P., 2021, Med J Ankara Train Res Hosp, V54, P59, DOI [10.20492/aeahtd.806164, DOI 10.20492/AEAHTD.806164]
   Kreitzer MJ, 2015, RAMBAM MAIMONIDES ME, V6, DOI 10.5041/RMMJ.10200
   MELZACK R, 1987, PAIN, V30, P191, DOI 10.1016/0304-3959(87)91074-8
   Miao J, 2017, INT J NURS STUD, V70, P27, DOI 10.1016/j.ijnurstu.2017.02.014
   Nurjannah I, 2021, COMPLEMENT THER CLIN, V43, DOI 10.1016/j.ctcp.2021.101337
   Okuyama T, 2000, J PAIN SYMPTOM MANAG, V19, P5, DOI 10.1016/S0885-3924(99)00138-4
   Pérez Cruz Julio César, 2018, ccm, V22, P549
   Rhodes V A, 1984, Cancer Nurs, V7, P33
   Sahin S, 2018, TURK J MED SCI, V48, P124, DOI 10.3906/sag-1707-125
   Scarborough BM, 2018, CA-CANCER J CLIN, V68, P182, DOI 10.3322/caac.21453
   Schulz KF, 2010, EPIDEMIOL BIOSTAT PU, V7, P325
   Seth SS., 2013, Altern Integr Med, V2, P91
   Simsek HE, 2022, COMPLEMENT THER CLIN, V49, DOI 10.1016/j.ctcp.2022.101642
   Stavropoulou A, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18168512
   Tan JY, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03543-y
   Tantoy IY, 2018, J PAIN SYMPTOM MANAG, V55, P808, DOI 10.1016/j.jpainsymman.2017.10.004
   Uysal N, 2017, INT J NURS PRACT, V23, DOI 10.1111/ijn.12532
   Wang Ya-Ling, 2019, Zhongguo Zhen Jiu, V39, P1269, DOI 10.13703/j.0255-2930.2019.12.004
   Wei TT, 2020, SUPPORT CARE CANCER, V28, P4031, DOI 10.1007/s00520-020-05409-w
   Woo PJ., 2000, Seed therapy
   Woo PJ., 1991, Su Jok for everybody
   World Health Organization, 2022, All cancers
   World health organization, 2022, Cancer today
   Yagil Z, 2019, QUADERNO, V14, P51
   Zhang JL, 2022, PHYTOMEDICINE, V102, DOI 10.1016/j.phymed.2022.154160
   Zorba P, 2018, CANCER NURS, V41, P359, DOI 10.1097/NCC.0000000000000496
NR 55
TC 1
Z9 1
U1 19
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0887-9311
EI 1550-5138
J9 HOLIST NURS PRACT
JI Holist. Nurs. Pract.
PD SEP-OCT
PY 2025
VL 39
IS 5
BP 283
EP 294
DI 10.1097/HNP.0000000000000713
PG 12
WC Integrative & Complementary Medicine; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine; Nursing
GA 6II2G
UT WOS:001554044400002
PM 39642275
DA 2026-01-16
ER

PT J
AU Yu, X
   Gong, SY
   Luo, Q
   Xu, GX
   Tian, H
   Li, Q
   Chen, M
   Yang, S
   Yu, SG
AF Yu, Xin
   Gong, Si-yao
   Luo, Qin
   Xu, Gui-xing
   Tian, Hao
   Li, Qian
   Chen, Ming
   Yang, Sha
   Yu, Shu-guang
TI Effectiveness of Acupuncture in Improving Quality of Life for Patients
   with Advanced Cancer: A Systematic Review and Meta-Analysis
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Review
DE acupuncture; advanced cancer; palliative care; meta-analysis; quality of
   life
ID PALLIATIVE CARE; LUNG-CANCER; CHEMOTHERAPY; SYMPTOMS; THERAPY
AB ObjectiveTo investigate the effect of acupuncture on advanced cancer patients by meta-analysis.MethodsNine databases (the Cochrane Central Register of Controlled Trials, MEDLINE, Web of Science, Embase, China National Knowledge Infrastructure, the Cumulative Index to Nursing and Allied Health Literature, Chinese Biomedical Literature Database, China Science and Technology Journal Database, and WanFang Data) were searched for randomized controlled trials (RCTs) on acupuncture in advanced cancer patients published from inception to February 13, 2023 and updated to June 1, 2023. Primary outcomes were quality of life (QOL), while secondary outcomes were pain, fatigue, and adverse events (side effects). Data synthesis was performed using RevMan V.5.3 to calculate pooled effect sizes. RoB-2 was used for the risk of bias, and the quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool.ResultsTotally 17 RCTs involving 1,178 participants were included, 15 of which were pooled for meta-analysis. Most studies demonstrated some concern for the overall risk of bias. The pooled data indicated that acupuncture was associated with improved QOL [mean difference (MD)=6.67, 95% confidence interval (CI): 5.09 to 8.26], pain (MD=-1.18, 95% CI -2.28 to -0.08), and adverse events (risk ratio=0.30, 95% CI: 0.26 to 0.57) compared with control groups. Fatigue outcome was not included. Heterogeneity was substantial, and GRADE evidence was very low for both QOL and pain.ConclusionsAcupuncture could benefit patients with advanced cancer and is considered safe compared with usual care. However, the evidence regarding QOL and pain outcomes requires further validation. It is crucial to encourage the development of high-quality studies to strengthen this evidence. (Registry No. CRD42023423539)
C1 [Yu, Xin; Gong, Si-yao; Luo, Qin; Xu, Gui-xing; Tian, Hao; Li, Qian; Chen, Ming; Yang, Sha; Yu, Shu-guang] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu 610075, Peoples R China.
   [Li, Qian] Panzhihua Univ, Sch Hlth & Wellness, Panzhihua 617099, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Panzhihua University
RP Yang, S (corresponding author), Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu 610075, Peoples R China.
EM yangsha@cdutcm.edu.cn
OI Tian, Hao/0000-0002-9823-0749
FU National Natural Science Foundation of China [82004487, 82230127];
   Central Guidance for Local Projects of Sichuan Province [2022ZYD0101]
FX Supported by the National Natural Science Foundation of China (Nos.
   82004487 and 82230127) and Central Guidance for Local Projects of
   Sichuan Province (No. 2022ZYD0101)
CR Buss MK, 2017, MAYO CLIN PROC, V92, P280, DOI 10.1016/j.mayocp.2016.11.007
   Chae Y, 2017, ACUPUNCT MED, V35, P148, DOI 10.1136/acupmed-2016-011178
   Choi TY, 2022, CANCERS, V14, DOI 10.3390/cancers14184419
   Crawford GB, 2021, ESMO OPEN, V6, DOI 10.1016/j.esmoop.2021.100225
   Cui Y, 2004, BREAST CANCER RES TR, V85, P263, DOI 10.1023/B:BREA.0000025422.26148.8d
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Deng Xiao-Yue, 2019, Zhongguo Zhen Jiu, V39, P379, DOI 10.13703/j.0255-2930.2019.04.009
   Deng XY., 2018, J ZHEJIANG U TRADIT, V42, P748, DOI DOI 10.16466/J.ISSN1005-5509.2018.09.018
   Feng R, 2015, DIAGN PATHOL, V10, DOI 10.1186/s13000-015-0382-1
   Ferrell BR, 2017, J CLIN ONCOL, V35, P96, DOI 10.1200/JCO.2016.70.1474
   Fulton JJ, 2019, PALLIATIVE MED, V33, P123, DOI 10.1177/0269216318812633
   Gan D., 2020, SICHUAN J TRADIT CHI, V38, P210
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Geerse OP, 2021, J PALLIAT MED, V24, P53, DOI 10.1089/jpm.2019.0615
   Giesinger JM, 2011, J PALLIAT MED, V14, P904, DOI 10.1089/jpm.2011.0086
   Granger C, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012020.pub3
   [何佩珊 He Peishan], 2020, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V35, P5313
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Höxtermann MD, 2022, CANCER-AM CANCER SOC, V128, P2159, DOI 10.1002/cncr.34165
   Kim K, 2018, INTEGR CANCER THER, V17, P1137, DOI 10.1177/1534735418786797
   Kiss Z, 2023, FRONT ONCOL, V13, DOI 10.3389/fonc.2023.1207295
   Langevin Helene M, 2016, Cancer Res, V76, P6159, DOI 10.1158/0008-5472.can-16-0753
   LeBlanc TW, 2015, LANCET ONCOL, V16, pE333, DOI 10.1016/S1470-2045(15)00080-7
   Li YH., 2014, SHANGHAI J ACUPUNCT, V33, P211
   Liu YQ, 2015, CHIN J INTEGR MED, V21, P697, DOI 10.1007/s11655-014-2009-x
   Lu L, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.28776
   Luo XC, 2023, J EVID-BASED MED, V16, P237, DOI 10.1111/jebm.12526
   Ma J., 2021, CHIN MED MODERN DIST, V19, P119
   MacPherson H, 2017, PAIN, V158, P784, DOI 10.1097/j.pain.0000000000000747
   Mao JJ, 2022, CA-CANCER J CLIN, V72, P144, DOI 10.3322/caac.21706
   Miao XM, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/8701779
   Minchom A, 2016, EUR J CANCER, V61, P102, DOI 10.1016/j.ejca.2016.03.078
   Ni WM., 2018, SHANGHAI ZHENJIU ZAZ, V37, P1020
   Noorlandt H, 2022, EUR J CANCER CARE, V31, DOI 10.1111/ecc.13638
   Oh B, 2018, INTEGR CANCER THER, V17, P458, DOI 10.1177/1534735417734912
   Okuyama T, 2017, CANCER TREAT REV, V56, P16, DOI 10.1016/j.ctrv.2017.03.012
   Page Matthew J, 2021, BMJ, V372, pn71, DOI [10.1016/j.ijsu.2021.105906, 10.1136/bmj.n71]
   Paley CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub3
   Papadopoulou M, 2023, IN VIVO, V37, P47, DOI 10.21873/invivo.13053
   Peng GY., 2016, J GUANGDONG COLL PHA, V32, P522
   Puhan MA, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g5630
   Saraswati W, 2021, J ACUPUNCT MERIDIAN, V14, P5, DOI 10.51507/j.jams.2021.14.1.4
   Schenker Y, 2021, JAMA INTERN MED, V181, P1451, DOI 10.1001/jamainternmed.2021.5185
   Su CF, 2018, J INTEGR MED-JIM, V16, P208, DOI 10.1016/j.joim.2018.04.003
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Swetz KM, 2018, ANN INTERN MED, V168, pITC33, DOI 10.7326/AITC201803060
   Verma N, 2021, J CLIN HYPERTENS, V23, P1275, DOI 10.1111/jch.14236
   von Trott P, 2020, J PAIN SYMPTOM MANAG, V59, P327, DOI 10.1016/j.jpainsymman.2019.09.007
   Wang WM, 2021, ACUPUNCT MED, V39, P272, DOI 10.1177/0964528420947739
   Wang XP., 2017, J NAVAL MED CHIN, V38, P353
   Wang Y., 2017, Zhejiang J Tradit Chin Med, V52, P684
   *WHO, 2020, PALL CAR
   Xie LF, 2023, BMC COMPLEMENT MED, V23, DOI 10.1186/s12906-023-03926-9
   Yang HN., 2023, LIAONING J TRADIT CH, V50, P159
   Yin S., 2021, SHANGHAI J ACUPUNCT, V40, P21, DOI [DOI 10.13460/J.ISSN.1005-0957.2008.12.009, DOI 10.13460/J.ISSN.1005-0957.2020.01.0021]
   Yu Z, 2014, J TRADIT CHIN MED, V34, P754, DOI 10.1016/S0254-6272(15)30092-3
   Zeng YC, 2018, INTEGR CANCER THER, V17, P737, DOI 10.1177/1534735418777109
   Zhang XY, 2021, BIOSCI TRENDS, V15, P283, DOI 10.5582/bst.2021.01318
   Zhang X, 2023, FRONT ONCOL, V13, DOI 10.3389/fonc.2023.1206196
   Zheng X., 2021, J GANSU U CHIN MED C, V38, P64, DOI DOI 10.16841/J.ISSN1003-8450.2021.06.13
   Zhou J, 2017, CURR ONCOL, V24, pE1, DOI 10.3747/co.24.3296
   Zimmermann C, 2014, LANCET, V383, P1721, DOI 10.1016/S0140-6736(13)62416-2
NR 62
TC 1
Z9 2
U1 7
U2 17
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD APR
PY 2025
VL 31
IS 4
BP 360
EP 371
DI 10.1007/s11655-024-4119-4
EA OCT 2024
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 1JM2D
UT WOS:001334459000001
PM 39417952
DA 2026-01-16
ER

PT J
AU Wu, CC
   Yang, JF
   Zhang, QY
   Liu, W
   Liao, K
   Hu, B
AF Wu, Chuncheng
   Yang, Juliana F.
   Zhang, Qiongying
   Liu, Wei
   Liao, Ke
   Hu, Bing
TI Successful cholangioscopic electrocoagulation for biliary
   papillomatosis: Report covering six cases (with video)
SO GASTROENTEROLOGIA Y HEPATOLOGIA
LA English
DT Article
DE Cholangioscopic; Electrocoagulation; Biliary papillomatosis
ID BILE-DUCTS; THERAPY
AB Background: Biliary papillomatosis is a rare type of papillomatosis. Depending on the location of the disease, radical surgical resection or liver transplants are the treatment of choice. These radical surgical options may be unrealistic in patients who are not surgical candidates or who are unwilling to consider surgery.
   Aims: To evaluate the effectiveness of endoscopic electrocoagulation for the biliary papillomatosis.
   Methods: In this case series, we report six patients with unresectable biliary papillomatosis who underwent cholangioscopic electrocoagulation using needle knife and their clinic follow up information.
   Results: After patients received cholangioscopy with electrocoagulation of the residual biliary papilloma, the daily T-tube drainage volume increased to 200-400 ml with improvement in the drainage content and significant relief of clinical symptoms, such as jaundice and abdominal pain.
   Conclusion: This method of using electrocoagulation to directly target and destroy tumor tissue is a safe and effective alternative for those with unresectable disease, and this method has shown to enhance T-tube drainage volume and improve patients' overall clinical symptoms. (C) 2021 Elsevier Espana, S.L.U. All rights reserved.
C1 [Wu, Chuncheng; Zhang, Qiongying; Liu, Wei; Liao, Ke; Hu, Bing] Sichuan Univ, West China Hosp, Dept Gastroenterol, Chengdu, Peoples R China.
   [Yang, Juliana F.] Vanderbilt Univ, Med Ctr, Dept Internal Med, Div Digest & Liver Dis, Nashville, TN USA.
C3 Sichuan University; Vanderbilt University
RP Hu, B (corresponding author), Sichuan Univ, West China Hosp, Dept Gastroenterol, Chengdu, Peoples R China.
EM hubingnj@163.com
FU Sichuan Province Science and Technology Department (China) [2018SZ0134]
FX The authors want to thank Sichuan Province Science and Technology
   Department (China) (2018SZ0134) for their support.
CR Adioui Tarik, 2014, J Med Case Rep, V8, P148, DOI 10.1186/1752-1947-8-148
   Baughman SM, 2005, J GASTROINTEST SURG, V9, P215, DOI 10.1016/j.gassur.2004.07.005
   Beavers K L, 2001, Liver Transpl, V7, P264, DOI 10.1053/jlts.2001.22322
   Bechmann LP, 2008, WORLD J GASTROENTERO, V14, P4234, DOI 10.3748/wjg.14.4234
   Caroli J, 1973, Clin Gastroenterol, V2, P147
   CHAPPET V, 1894, Lyon Medical, V76, P145
   DAbrigeon G, 1997, GASTROINTEST ENDOSC, V46, P237, DOI 10.1016/S0016-5107(97)70093-2
   Donnellan F, 2011, ENDOSCOPY, V43, pE86, DOI 10.1055/s-0030-1255976
   Gu CC, 2015, ONCOL LETT, V10, P3315, DOI 10.3892/ol.2015.3682
   Gunvén P, 2000, CANCER-AM CANCER SOC, V89, P69, DOI 10.1002/1097-0142(20000701)89:1<69::AID-CNCR10>3.0.CO;2-9
   HOLTKAMP W, 1994, AM J GASTROENTEROL, V89, P2253
   Hsu YQ, 2014, HONG KONG MED J, V20
   Itoi T, 2009, DIGEST ENDOSC, V21, pS103, DOI 10.1111/j.1443-1661.2009.00849.x
   Iwasaki Y, 2002, SURG TODAY, V32, P1019, DOI 10.1007/s005950200206
   Jazrawi SR, 2009, GASTROINTEST ENDOSC, V69, P372, DOI 10.1016/j.gie.2008.03.1095
   Kim HJ, 2000, ENDOSCOPY, V32, P389, DOI 10.1055/s-2000-8996
   Kim YS, 1998, ENDOSCOPY, V30, P763, DOI 10.1055/s-2007-1001418
   Kim YS, 1998, GASTROINTEST ENDOSC, V47, P563
   Lee PSF, 2001, CLIN RADIOL, V56, P591, DOI 10.1053/crad.2000.0610
   Lee SS, 2004, CANCER-AM CANCER SOC, V100, P783, DOI 10.1002/cncr.20031
   Li ZQ, 2015, INT J CLIN EXP MED, V8, P21802
   NAKAJIMA T, 1988, HUM PATHOL, V19, P1228, DOI 10.1016/S0046-8177(88)80156-4
   Parsi MA, 2015, GASTROINTEST ENDOSC, V81, P231, DOI 10.1016/j.gie.2014.04.040
   Sotiropoulos GC, 2003, SURG TODAY, V33, P781, DOI 10.1007/s00595-003-2595-2
   TAGUCHI J, 1993, ARCH PATHOL LAB MED, V117, P944
   Vassiliou Ioannis, 2006, World J Surg Oncol, V4, P71, DOI 10.1186/1477-7819-4-71
   Yeh TS, 2006, ANN SURG, V244, P248, DOI 10.1097/01.sla.0000217636.40050.54
   Yeung Yuk Pang, 2003, J Hepatobiliary Pancreat Surg, V10, P390, DOI 10.1007/s00534-002-0837-0
NR 28
TC 3
Z9 3
U1 0
U2 7
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0210-5705
J9 GASTROENT HEPAT-BARC
JI Gastroenterol. Hepatol.
PD OCT
PY 2021
VL 44
IS 8
BP 546
EP 551
DI 10.1016/j.gastrohep.2020.12.012
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA YO2YX
UT WOS:000747812000002
PM 33617929
DA 2026-01-16
ER

PT J
AU Tola, YO
   Chow, KM
   Liang, W
AF Tola, Yetunde Oluwafunmilayo
   Chow, Ka Ming
   Liang, Wei
TI Effects of non-pharmacological interventions on preoperative anxiety and
   postoperative pain in patients undergoing breast cancer surgery: A
   systematic review
SO JOURNAL OF CLINICAL NURSING
LA English
DT Review
DE anxiety; breast cancer surgery; non&#8208; medicine; non&#8208;
   pharmacological; pain
ID CLINICAL-PRACTICE GUIDELINE; PERSISTENT PAIN; MUSIC-THERAPY; MANAGEMENT;
   WOMEN; AROMATHERAPY; ANESTHESIA; SOCIETY; IMPACT; TRIAL
AB Background Poorly managed preoperative anxiety and pain were reported to slow the postoperative recovery of breast cancer patients. Thus, proactive management using non-pharmacological interventions becomes essential for decreasing opioid or anxiolytics consumption, anxiety level, pain intensity, postoperative complications and improving patients' haemodynamics and satisfaction with care.
   Purpose To identify, analyse and synthesise the effects of non-pharmacological interventions on preoperative anxiety and acute postoperative pain in women undergoing breast cancer surgery.
   Method For this systematic review, 12 databases including Ovid Nursing, PsycInfo, British Nursing Index, CINAHL, Cochrane Library were searched to identify relevant studies. A total of 6,012 articles were identified from the search, six RCTs and one quasi-experimental study that met the inclusion criteria were included after eligibility screening. Narrative synthesis was used to analyse data extracted from the included articles. The review adhered to the PRISMA guideline.
   Results Twelve outcomes were measured in the included studies, including preoperative anxiety, and acute postoperative pain. Music, massage, aromatherapy and acupuncture were the interventions delivered. Music had a small-to-large effect size and aromatherapy had a small effect size on reducing preoperative anxiety. Also, music had a large effect size whilst acupuncture had a medium effect size on minimising postoperative pain in women undergoing breast cancer surgery.
   Conclusion Music, aromatherapy and acupuncture appeared to be effective for reducing preoperative anxiety and postoperative pain in women undergoing breast cancer surgery. However, the small number of studies available for each intervention prevents conclusive statements about which the most effective method.
   Implication for clinical practice A nursing care pathway that standardises the use of non-pharmacological interventions for the management of both preoperative anxiety and postoperative pain in breast cancer surgery patients should be developed.
C1 [Tola, Yetunde Oluwafunmilayo; Liang, Wei] Chinese Univ Hong Kong, Nethersole Sch Nursing, Hong Kong, Peoples R China.
   [Tola, Yetunde Oluwafunmilayo; Chow, Ka Ming] Inst Nursing Res, Osogbo, Nigeria.
C3 Chinese University of Hong Kong
RP Chow, KM (corresponding author), Chinese Univ Hong Kong, Nethersole Sch Nursing, Fac Med, 829 Esther Lee Bldg, Hong Kong, Peoples R China.
EM kmchow@cuhk.edu.hk
RI TOLA, Yetunde Oluwafunmilayo/ABV-1289-2022; Liang, Wei/OZD-9042-2025;
   Chow, Ka/A-3988-2015
OI TOLA, Yetunde Oluwafunmilayo/0000-0001-9408-0694; Liang,
   Wei/0000-0001-5195-5761; 
CR Anagnostopoulos Fotios., 2015, Encyclopedia of Quality of Life and Well-Being Research and Well-Being Research, V141, P3855, DOI DOI 10.1007/978-94-007-0753-5
   Andersen KG, 2015, PAIN, V156, P2413, DOI 10.1097/j.pain.0000000000000298
   Andersen KG, 2011, J PAIN, V12, P725, DOI 10.1016/j.jpain.2010.12.005
   [Anonymous], 2009, BMJ-BRIT MED J, V6, pe1000097, DOI [DOI 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, DOI 10.1371/JOURNAL.PMED.1000097]
   [Anonymous], 2018, 2018 mid-year report, P1
   Best JT, 2018, J PERIANESTH NURS, V33, P453, DOI 10.1016/j.jopan.2016.02.014
   Beyliklioglu A, 2019, J PERIANESTH NURS, V34, P587, DOI 10.1016/j.jopan.2018.10.002
   Binns-Turner Pamela G, 2011, AANA J, V79, pS21
   Bradt J, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006908.pub2
   Bruce J, 2014, PAIN, V155, P232, DOI 10.1016/j.pain.2013.09.028
   Chen HN, 2010, COMMUN STAT-SIMUL C, V39, P860, DOI 10.1080/03610911003650383
   Chou R, 2016, J PAIN, V17, P131, DOI 10.1016/j.jpain.2015.12.008
   Dion LJ, 2016, COMPLEMENT THER CLIN, V23, P82, DOI 10.1016/j.ctcp.2015.04.005
   Donelli D, 2019, PHYTOMEDICINE, V65, DOI 10.1016/j.phymed.2019.153099
   Evans H, 2019, Iris Journal of Nursing & Care, V1, DOI [10.33552/ijnc.2019.01.000512, 10.33552/IJNC.2019.01.000512, DOI 10.33552/IJNC.2019.01.000512]
   Fayazi Sadigheh, 2011, Iran J Nurs Midwifery Res, V16, P278
   Franco L, 2016, J CLIN ANESTH, V33, P243, DOI 10.1016/j.jclinane.2016.02.032
   Goulet-Pelletier JC, 2018, QUANT METH PSYCHOL, V14, P242, DOI 10.20982/tqmp.14.4.p242
   Haun M, 2001, BEHAV MED, V27, P127, DOI 10.1080/08964280109595779
   Kayode Kayode K. K., 2018, Academia, V4 4, P1
   Kühlmann AYR, 2018, BJS-BRIT J SURG, V105, P773, DOI 10.1002/bjs.10853
   Kulkarni AR, 2021, JPRAS OPEN, V30, P170, DOI 10.1016/j.jpra.2016.08.005
   Larsson IM, 2017, BREAST J, V23, P338, DOI 10.1111/tbj.12739
   Lee Jin-Hyung., 2015, The Effects of Music on Pain: A Review of Systematic Reviews and Meta-Analysis
   Li XM, 2011, BREAST CANCER RES TR, V128, P411, DOI 10.1007/s10549-011-1533-z
   Liu Y, 2015, COMPLEMENT THER MED, V23, P714, DOI 10.1016/j.ctim.2015.08.002
   Loukas M, 2011, AM SURGEON, V77, P566
   Luan RL, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000015923
   McLeod S.A., 2017, WHAT DOES EFFECT SIZ
   Nilsson Ulrica, 2008, AORN J, V87, P780, DOI 10.1016/j.aorn.2007.09.013
   Odejobi YO, 2019, INT NURS REV, V66, P434, DOI 10.1111/inr.12515
   Öztürk R, 2018, COMPLEMENT THER MED, V36, P107, DOI 10.1016/j.ctim.2017.12.005
   Paice JA, 2016, J ONCOL PRACT, V12, P757, DOI 10.1200/JOP.2016.014837
   Palmer JB, 2015, J CLIN ONCOL, V33, P3162, DOI 10.1200/JCO.2014.59.6049
   Polit D.F., 2012, Nursing research: Generating and assessing evidence for nursing research, V9th, DOI DOI 10.1097/00003465-199201000-00015
   Poulsen MJ, 2018, PAIN MANAG NURS, V19, P172, DOI 10.1016/j.pmn.2017.09.003
   Quinlan-Woodward J, 2016, ONCOL NURS FORUM, V43, P725, DOI 10.1188/16.ONF.725-732
   Robb SL, 2011, J HEALTH PSYCHOL, V16, P342, DOI 10.1177/1359105310374781
   Runowicz CD, 2016, J CLIN ONCOL, V34, P611, DOI 10.1200/JCO.2015.64.3809
   Schreiber KL, 2014, PAIN MANAG, V4, P445, DOI [10.2217/PMT.14.33, 10.2217/pmt.14.33]
   Schreiber KL, 2013, PAIN, V154, P660, DOI 10.1016/j.pain.2012.11.015
   Sin WM, 2015, PAIN MANAG NURS, V16, P978, DOI 10.1016/j.pmn.2015.06.008
   Stamenkovic DM, 2018, MINERVA ANESTESIOL, V84, P1307, DOI 10.23736/S0375-9393.18.12520-X
   Tamaki K, 2017, BREAST CANCER RES TR, V162, P523, DOI 10.1007/s10549-017-4134-7
   Tufanaru C., 2017, JBI MANUAL EVIDENCE, DOI DOI 10.46658/JBIMES-20-04
   Ucuzal M, 2014, PAIN MANAG NURS, V15, P458, DOI 10.1016/j.pmn.2012.03.001
   Yinger OS, 2015, J MUSIC THER, V52, P1, DOI 10.1093/jmt/thv004
   Zhou KN, 2015, EUR J ONCOL NURS, V19, P54, DOI 10.1016/j.ejon.2014.07.010
NR 48
TC 74
Z9 98
U1 5
U2 53
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD DEC
PY 2021
VL 30
IS 23-24
BP 3369
EP 3384
DI 10.1111/jocn.15827
EA MAY 2021
PG 16
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA XE8JO
UT WOS:000646404000001
PM 33942405
DA 2026-01-16
ER

PT J
AU Guo, Q
   Di, Z
   Tian, HF
   Zhang, QA
AF Guo, Qin
   Di, Zhong
   Tian, Hong-Fang
   Zhang, Quan-Ai
TI Contralateral Acupuncture for the Treatment of Phantom Limb Pain and
   Phantom Limb Sensation in Oncologic Lower Limb Amputee: A Case Report
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE acupuncture; contralateral acupuncture; phantom limb pain (PLP); phantom
   limb sensation (PLS); phantom limb
AB Phantom limb pain (PLP) and phantom limb sensation (PLS) are common and distressing sequelae of amputation. Current pain management following amputation is challenging and unsatisfying. In this case study, a 74-year-old woman underwent above-knee amputation because of the rhabdomyosarcoma in the right leg. Despite several analgesics, pain was poorly controlled. The phantom limb pain and sensation were immediately reduced by the contralateral acupuncture, and abolished after the third session with no side-effects, no relapse during the next 9 months. Contralateral acupuncture showed positive effect on PLP and PLS in this case, but more robust evidence would be needed to support the efficacy of this treatment technique for indication.</p>
C1 [Guo, Qin; Di, Zhong; Tian, Hong-Fang; Zhang, Quan-Ai] Zhejiang Chinese Med Univ, Dept Acupuncture & Moxibust, Affiliated Hosp 3, Hangzhou, Peoples R China.
C3 Zhejiang Chinese Medical University
RP Zhang, QA (corresponding author), Zhejiang Chinese Med Univ, Dept Acupuncture & Moxibust, Affiliated Hosp 3, Hangzhou, Peoples R China.
EM marvinguoo@126.com
CR Aternali Andrea, 2019, F1000Res, V8, DOI [10.12688/f1000research.19355.1, 10.12688/f1000research.19355.1]
   Becker S, 2018, PAIN RES MANAG, V2018, DOI 10.1155/2018/9305026
   BING Z, 1990, NEUROSCIENCE, V37, P809, DOI 10.1016/0306-4522(90)90110-P
   BING Z, 1991, NEUROSCIENCE, V44, P693, DOI 10.1016/0306-4522(91)90088-6
   Black JA, 2008, ANN NEUROL, V64, P644, DOI 10.1002/ana.21527
   Bouhassira D, 2004, PAIN, V108, P248, DOI 10.1016/j.pain.2003.12.024
   Bradbrook David, 2004, Acupunct Med, V22, P93
   Cheng B, 1996, J Tradit Chin Med, V16, P35
   Colquhoun Liz, 2019, Br J Nurs, V28, P638, DOI [10.12968/bjon.2019.28.10.638, 10.12968/bjon.2019.28.10.638]
   Cruz VT, 2003, NEUROREHABILITATION, V18, P299
   Davies A, 2013, ACUPUNCT MED, V31, P101, DOI 10.1136/acupmed-2012-010270
   Erlenwein J, 2021, PAIN REP, V6, DOI 10.1097/PR9.0000000000000888
   Flor H, 2002, LANCET NEUROL, V1, P182, DOI 10.1016/S1474-4422(02)00074-1
   Flor H, 2006, NAT REV NEUROSCI, V7, P873, DOI 10.1038/nrn1991
   Fuchs X, 2018, PAIN RES MANAG, V2018, DOI 10.1155/2018/5080123
   Gao Z, 2021, J PAIN RES, V14, DOI 10.2147/JPR.S300911
   Hayhoe S, 2016, ACUPUNCT MED, V34, P55, DOI 10.1136/acupmed-2015-211984rep
   HE LF, 1987, PAIN, V31, P99, DOI 10.1016/0304-3959(87)90011-X
   Jacobs MB, 2011, MED ACUPUNCT, V23, P57, DOI 10.1089/acu.2010.0785
   KATZ J, 1990, PAIN, V43, P319, DOI 10.1016/0304-3959(90)90029-D
   Kaur A, 2018, CHIN J TRAUMATOL, V21, P366, DOI 10.1016/j.cjtee.2018.04.006
   Lai HC, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6173412
   Li ZJ, 2017, NEUROIMAGE-CLIN, V15, P367, DOI 10.1016/j.nicl.2017.05.013
   Lin LL, 2021, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.626497
   Lu F, 1997, J Tradit Chin Med, V17, P124
   Lyu ZX, 2021, NEURAL PLAST, V2021, DOI 10.1155/2021/8881557
   Mannix SM, 2013, MED ACUPUNCT, V25, P23, DOI 10.1089/acu.2012.0928
   Nikolajsen L, 1996, PAIN, V67, P69, DOI 10.1016/0304-3959(96)03080-1
   Raggi A, 2019, EUR NEUROL, V81, P302, DOI 10.1159/000503103
   Shi Y, 2020, NEURAL PLAST, V2020, DOI 10.1155/2020/8865096
   Stankevicius A, 2021, EUR J PAIN, V25, P23, DOI 10.1002/ejp.1657
   Sui Shuxue, 2004, J Tradit Chin Med, V24, P46
   Sun J, 2015, BEHAV BRAIN FUNCT, V11, DOI 10.1186/s12993-015-0055-y
   Trevelyan EG, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1639-z
   Tseng CC, 2014, ACUPUNCT MED, V32, P356, DOI 10.1136/acupmed-2014-010556
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Yi M, 2011, MOL PAIN, V7, DOI 10.1186/1744-8069-7-61
   Zhang HL, 2016, ACUPUNCT MED, V34, P164, DOI 10.1136/acupmed-2015-010947
   Zhang RX, 2014, ANESTHESIOLOGY, V120, P482, DOI 10.1097/ALN.0000000000000101
NR 39
TC 8
Z9 9
U1 0
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD OCT 22
PY 2021
VL 15
AR 713548
DI 10.3389/fnins.2021.713548
PG 5
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA WU2DS
UT WOS:000716361500001
PM 34744604
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Victorson, D
   Beaumont, JL
   Mahadevan, R
   Grimone, A
   Burns, V
   Murry, W
   Gutierrez, S
   Schuette, S
   Brady, C
   Ring, M
AF Victorson, David
   Beaumont, Jennifer L.
   Mahadevan, Rupa
   Grimone, Ania
   Burns, Virginia
   Murry, Wendy
   Gutierrez, Sandra
   Schuette, Stephanie
   Brady, Caitlin
   Ring, Melinda
TI Acupuncture-Related Quality of Life Changes Using PROMIS Computer
   Adaptive Tests in a Pragmatic Trial with Oncology and General
   Integrative Medicine Patients: The Role of Baseline Acupuncture
   Expectations
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE acupuncture; quality of life; outcomes; pragmatic trial
ID CANCER; RELIEF
AB Introduction: Acupuncture has been shown to alleviate symptoms and increase general well-being in different medical patient samples. A major challenge in acupuncture clinical research is the availability of comparable and standardized patient-reported outcome measurement (PRO) tools. Objectives: This study used a pragmatic design to examine longitudinal changes in quality of life (QOL) in a medical patient sample following acupuncture using PROs from the National Institutes of Health's Patient Reported Outcomes Measurement Information System (PROMIS) initiative. It also examined the role of acupuncture expectancies, as well as patient and provider perceptions of acupuncture benefit. Design: Following informed consent, patients completed baseline QOL measures (T1) prior to their first acupuncture session. Subsequent assessments (up to 20) were completed immediately following ensuing acupuncture sessions. Patients completed assessments either on a touch-screen computer at the clinic or from their home computer. Results: Compared with acupuncture-naive participants, those who received prior acupuncture treatment reported significantly higher anxiety, fatigue, sleep disturbance, and lower positive affect at baseline. By the second assessment, however, these differences became nonexistent. Participants who held greater baseline acupuncture expectations (e.g., their situation would improve a lot, they would have improved coping skills, their symptoms would disappear, their energy would increase) reported significantly higher fatigue, pain interference, and problems with physical functioning. Between T1 and T2, all participants reported significant improvements in anxiety, depression, and fatigue. Exploratory longitudinal models demonstrated significant linear improvements over time in anxiety (p=0.006), depression (p=0.007), pain interference (p<0.001), and sleep disturbance (p=0.004). No linear reduction over time was found with fatigue (p=0.587), physical function (p=0.654), or positive affect (p=0.247). Conclusions: Overall, PROMIS computer adaptive tests were able to assess domains of QOL briefly. Although pretreatment acupuncture expectations highlighted subgroup differences in outcomes at baseline, linear-growth models demonstrated the positive effects of acupuncture over time on anxiety, depression, pain interference, and sleep disturbance.
C1 [Victorson, David; Beaumont, Jennifer L.; Gutierrez, Sandra] Northwestern Univ, Dept Med Social Sci, Feinberg Sch Med, 2205 Tech Dr,Hogan Bldg,Suite 2-120, Chicago, IL 60208 USA.
   [Victorson, David; Grimone, Ania; Burns, Virginia; Murry, Wendy; Schuette, Stephanie; Brady, Caitlin; Ring, Melinda] Northwestern Med Grp, Northwestern Med, Osher Ctr Integrat Med, Chicago, IL USA.
   [Mahadevan, Rupa] Advocate Childrens Hosp, Pediat Residency Program, Park Ridge, IL USA.
C3 Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine
RP Victorson, D (corresponding author), Northwestern Univ, Dept Med Social Sci, Feinberg Sch Med, 2205 Tech Dr,Hogan Bldg,Suite 2-120, Chicago, IL 60208 USA.
EM d-victorson@northwestern.edu
RI Schuette, Stephanie/OMM-7447-2025
OI Beaumont, Jennifer/0000-0002-1484-260X
FU Malkin Family Foundation; Osher Center for Integrative Medicine at
   Northwestern Medicine
FX The authors wish to acknowledge funding support for this study from the
   Malkin Family Foundation and the Osher Center for Integrative Medicine
   at Northwestern Medicine.
CR Brinkhaus B, 2008, ANN ALLERG ASTHMA IM, V101, P535, DOI 10.1016/S1081-1206(10)60294-3
   Cella D, 2010, J CLIN EPIDEMIOL, V63, P1179, DOI 10.1016/j.jclinepi.2010.04.011
   de Valois BA, 2012, EUR J ONCOL NURS, V16, P301, DOI 10.1016/j.ejon.2011.07.005
   Deng G, 2007, J CLIN ONCOL, V25, P5584, DOI 10.1200/JCO.2007.12.0774
   Devilly GJ, 2000, J BEHAV THER EXP PSY, V31, P73, DOI 10.1016/S0005-7916(00)00012-4
   Frisk J, 2012, SUPPORT CARE CANCER, V20, P715, DOI 10.1007/s00520-011-1134-8
   Gershon Richard C, 2010, J Appl Meas, V11, P304
   Hervik J, 2009, BREAST CANCER RES TR, V116, P311, DOI 10.1007/s10549-008-0210-3
   Johnston MF, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-49
   Konno R, 2010, CANCER NURS, V33, P479, DOI 10.1097/NCC.0b013e3181f104bc
   Lee H, 2005, EUR J PAIN, V9, P437, DOI 10.1016/j.ejpain.2004.10.004
   Lee Sang-Hun, 2011, Curr Urol Rep, V12, P288, DOI 10.1007/s11934-011-0186-0
   Linde K, 2001, INT J EPIDEMIOL, V30, P526, DOI 10.1093/ije/30.3.526
   Liodden I, 2011, ACUPUNCT MED, V29, P9, DOI 10.1136/aim.2010.002915
   McHorney CA, 2000, MED CARE, V38, P43
   Paley CA, 2011, EVID-BASED COMPL ALT, V2011
   Paley CA, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub2
   Patsopoulos Nikolaos A, 2011, Dialogues Clin Neurosci, V13, P217
   Peng Hao, 2010, Zhong Xi Yi Jie He Xue Bao, V8, P501
   Salsman JM, 2014, QUAL LIFE RES, V23, P205, DOI 10.1007/s11136-013-0452-3
   Stuardi T, 2012, J ALTERN COMPLEM MED, V18, P1021, DOI 10.1089/acm.2011.0670
   Wang Ya-Jun, 2010, Zhongguo Zhen Jiu, V30, P509
   Zhou J, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nep001
NR 23
TC 8
Z9 9
U1 0
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD OCT
PY 2016
VL 22
IS 10
BP 778
EP 787
DI 10.1089/acm.2015.0121
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA DZ5SU
UT WOS:000385922600004
PM 27467506
DA 2026-01-16
ER

PT J
AU Gu, YM
   Meng, X
   Liang, JY
   Xia, Y
   Huang, JW
   Wang, K
   Ju, ZY
AF Gu, Yi-Ming
   Meng, Xiang
   Liang, Jia-Yi
   Xia, Yong
   Huang, Jun-Wei
   Wang, Ke
   Ju, Zi-Yong
TI Electroacupuncture intervention relieves pain by stimulating the
   STING/IFN-I pathway in rat models of cancer-induced bone pain
SO MOLECULAR PAIN
LA English
DT Article
DE STING; IFN-I; analgesic effects; electroacupuncture; cancer-induced bone
   pain
ID PREVALENCE; MANAGEMENT; SOCIETY; INJURY
AB This study aimed to evaluate the effects of electroacupuncture (EA) on cancer-induced bone pain (CIBP) and investigate its interaction with the STING/IFN-I pathway. A CIBP model was established in female rats. EA was administered for six consecutive days at bilateral L3-L5 Jia Ji points (EX-B2). EA-induced antinociception was evaluated through mechanical, thermal, and cold sensitivity assessments. EA significantly increased the paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) in rats with CIBP (p < 0.01). In the spinal cord of CIBP model rats, western blot analysis demonstrated that the application of EA upregulated the expression of STING, IRF3, and IFNAR (p < 0.05). The ELISA results indicated that EA significantly increased the expression of IFN-alpha (p < 0.005) and IFN-beta (p < 0.01) and reduced the expression of TNF-alpha and IL-1 beta (p < 0.05). Immunofluorescence analysis revealed that STING was predominantly localized in microglia, with a minimal presence in neuronal cells. Furthermore, intrathecal administration of the STING antagonist C-176 attenuated the analgesic effects of EA in CIBP (p < 0.05). Both EA and STING agonist were effective in alleviating pain in rats with CIBP, possibly through the activation of the STING/IFN-I pathway. Notably, EA treatment reduced pro-inflammatory cytokines and increased anti-inflammatory cytokines. In contrast, while the STING agonist exhibited analgesic effects, it was associated with elevated levels of pro-inflammatory cytokines. These finding underscore the therapeutic potential of EA in the management of CIBP.
C1 [Gu, Yi-Ming; Meng, Xiang; Liang, Jia-Yi; Xia, Yong; Huang, Jun-Wei; Ju, Zi-Yong] Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China.
   [Wang, Ke] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese Med & Weste, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Ju, ZY (corresponding author), Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China.
EM juziyong@hotmail.com
RI Gu, Yiming/MVV-4414-2025
FU National Nature Science Foundation of China [81874506, 82474639]
FX <STRONG> </STRONG>The author(s) disclosed receipt of the following
   financial support for the research, authorship, and/or publication of
   this article: This research was funded by the National Nature Science
   Foundation of China (Grant No. 81874506, 82474639).
CR Bhatt K, 2024, ANN ONCOL, V35, P473, DOI 10.1016/j.annonc.2024.01.006
   Brigatte P, 2007, J PAIN, V8, P412, DOI 10.1016/j.jpain.2006.11.006
   Chen SY., 2010, Inner Mongolia J Tradit Chin Med, V29, P117
   Cheng ZL, 2020, SIGNAL TRANSDUCT TAR, V5, DOI 10.1038/s41392-020-0198-7
   Costantini M, 2009, ANN ONCOL, V20, P729, DOI 10.1093/annonc/mdn700
   Ding YY, 2023, J INTEGR MED-JIM, V21, P496, DOI 10.1016/j.joim.2023.07.001
   Donnelly CR, 2021, NATURE, V591, P275, DOI 10.1038/s41586-020-03151-1
   [杜俊英 Du Junying], 2014, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V29, P1454
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hou PP, 2021, CELL MOL IMMUNOL, V18, P2358, DOI 10.1038/s41423-021-00758-w
   Ishikawa H, 2008, NATURE, V455, P674, DOI 10.1038/nature07317
   Kane CM, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.h315
   Kim JH, 2004, BRAIN RES, V998, P230, DOI 10.1016/j.brainres.2003.11.045
   Lee SH, 2012, MOL MED REP, V6, P157, DOI 10.3892/mmr.2012.879
   Li Q., 2024, MedComm (2020), V5
   Li WW, 2020, SCI TRANSL MED, V12, DOI 10.1126/scitranslmed.aay9013
   Li YY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235917
   Liang JY., 2024, J Liaoning Univ Tradit Chin Med, V26, P61
   Liang Q, 2020, AM J CHINESE MED, V48, P1769, DOI 10.1142/S0192415X20500883
   Liang Y, 2018, INTEGR CANCER THER, V17, P401, DOI 10.1177/1534735417728335
   Liu QY, 2021, PAIN THER, V10, P1755, DOI 10.1007/s40122-021-00283-8
   Liu S, 2020, J PAIN, V21, P836, DOI 10.1016/j.jpain.2019.11.010
   Liu YD, 2022, FRONT SYNAPTIC NEURO, V14, DOI 10.3389/fnsyn.2022.891803
   Martini RS, 2024, CURR ONCOL REP, V26, P691, DOI 10.1007/s11912-024-01536-3
   Paice JA, 2016, J CLIN ONCOL, V34, P3325, DOI 10.1200/JCO.2016.68.5206
   Pan L, 2024, ASIAN J SURG, V47, P3288, DOI 10.1016/j.asjsur.2024.03.152
   Prudente AS, 2024, BRAIN BEHAV IMMUN, V117, P51, DOI 10.1016/j.bbi.2024.01.003
   Samson N, 2022, NAT CANCER, DOI 10.1038/s43018-022-00468-w
   Shenoy PA, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00286
   Sun J, 2022, J NEUROIMMUNE PHARM, V17, P453, DOI 10.1007/s11481-021-10031-6
   Tan PH, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.783725
   Tian SX, 2023, PURINERG SIGNAL, V19, P13, DOI 10.1007/s11302-022-09861-7
   van den Beuken-van Everdingen MHJ, 2016, J PAIN SYMPTOM MANAG, V51, P1070, DOI 10.1016/j.jpainsymman.2015.12.340
   Wang KY, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-24867-2
   Wang W, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.593043
   Wang Y., 2020, Guiding J Tradit Chin Med Pharm, V26, P90
   Wengström Y, 2014, EUR J ONCOL NURS, V18, P127, DOI 10.1016/j.ejon.2013.11.009
   Woller SA, 2019, BRAIN BEHAV IMMUN, V76, P151, DOI 10.1016/j.bbi.2018.11.014
   Woolf CJ, 2010, J CLIN INVEST, V120, P3742, DOI 10.1172/JCI45178
   Wu WY, 2022, NEUROPHARMACOLOGY, V217, DOI 10.1016/j.neuropharm.2022.109206
   Xiang XN, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20133248
   Xu J, 2016, ANESTH ANALG, V122, P882, DOI 10.1213/ANE.0000000000001097
   Xu M, 2021, ACS CHEM NEUROSCI, V12, P3323, DOI 10.1021/acschemneuro.1c00224
   Zhang CP, 2020, CHIN MED-UK, V15, DOI 10.1186/s13020-020-0289-y
   Zhang LY, 2021, FRONT MOL BIOSCI, V8, DOI 10.3389/fmolb.2021.647647
   Zhang XX, 2022, CANCERS, V14, DOI 10.3390/cancers14215188
   Zhang YX, 2023, INFLAMM RES, V72, P117, DOI 10.1007/s00011-022-01663-2
   Zhang ZY, 2021, LIFE SCI, V272, DOI 10.1016/j.lfs.2021.119259
   Zhao JG, 2017, ACUPUNCT MED, V35, P224, DOI 10.1136/acupmed-2016-011107
   Zhao YX, 2024, MOL PAIN, V20, DOI 10.1177/17448069241240692
   Zhu YY, 2019, MOL CANCER, V18, DOI 10.1186/s12943-019-1087-y
NR 52
TC 0
Z9 0
U1 3
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
EI 1744-8069
J9 MOL PAIN
JI Mol. Pain
PY 2025
VL 21
AR 17448069251342240
DI 10.1177/17448069251342240
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 3MD4S
UT WOS:001503634600001
PM 40331681
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Valencia, LMP
   He, YY
   Wippert, PM
AF Puerto Valencia, Laura Maria
   He, Yangyang
   Wippert, Pia-Maria
TI The changes of blood-based inflammatory biomarkers after
   non-pharmacologic interventions for chronic low back pain: a systematic
   review
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Anti-inflammatory cytokines; Interleukin; Pain management;
   Pro-inflammatory cytokines; Tumor necrosis factor alpha
ID ELEVATED PRODUCTION; CHEMOKINES; CYTOKINES; MEDIATORS; THERAPY
AB BackgroundChronic low back pain (CLBP) is a prevalent and debilitating condition, leading to significant challenges to both patients and the governmental healthcare system. Non-pharmacologic interventions have received increasing attention as potential strategies to alleviate chronic low back pain and improve patient outcomes. The aim of this systematic review was to comprehensively assess the changes in blood inflammatory biomarkers after non-pharmacologic interventions for CLBP patients, thus trying to understand the complex interactions between non-pharmacologic interventions and inflammatory biomarker changes in CLBP.MethodsA thorough search (from January 1st, 2002 to October 5th, 2022) of PubMed, Medline (platform Web of Science), and the Cochrane Library (platform Wiley Online Library) were conducted, and inclusion criteria as well as exclusion criteria were refined to selection of the studies. Rigorous assessments of study quality were performed using RoB 2 from Cochrane or an adaptation of the Downs and Black checklist. Data synthesis includes alterations in inflammatory biomarkers after various non-pharmacologic interventions, including exercise, acupressure, neuro-emotional technique, and other modalities.ResultsThirteen primary studies were included in this systematic review, eight randomized controlled trials, one quasi-randomized trial, and four before-after studies. The interventions studied consisted of osteopathic manual treatment (one study), spinal manipulative therapy (SMT) (three studies), exercise (two studies), yoga (two studies) and acupressure (two studies), neuro-emotional technique (one study), mindfulness-based (one study) and balneotherapy study (one study). Four studies reported some changes in the inflammatory biomarkers compared to the control group. Decreased tumor necrosis factor-alpha (TNF-alpha) after osteopathic manual treatment (OMT), neuro-emotional technique (NET), and yoga. Decreased interleukin (IL)-1, IL-6, IL-10, and c-reactive protein (CRP) after NET, and increased IL-4 after acupressure. Another five studies found changes in inflammatory biomarkers through pre- and post-intervention comparisons, indicating improvement outcomes after intervention. Increased IL-10 after balneotherapy; decreased TNF-alpha, IL-1 beta, IL-8, Interferon-gamma, interferon-gamma-induced protein 10-gamma-induced protein 10 after exercise; decreased IL-6 after exercise and SMT; decreased CRP and chemokine ligand 3 after SMT.ConclusionResults suggest a moderation of inflammatory biomarkers due to different non-pharmacologic interventions for CLBP, generally resulting in decreased pro-inflammatory markers such as TNF-alpha and IL-6 as well as increased anti-inflammatory markers such as IL-4, thus revealing the inhibition of inflammatory processes by different non-pharmacologic interventions. However, a limited number of high-quality studies evaluating similar interventions and similar biomarkers limits the conclusion of this review.
C1 [Puerto Valencia, Laura Maria; He, Yangyang; Wippert, Pia-Maria] Univ Potsdam, Med Sociol & Psychobiol, Potsdam, Germany.
   [He, Yangyang; Wippert, Pia-Maria] Brandenburg Univ Technol Cottbus Senftenberg, Fac Hlth Sci Brandenburg, Brandenburg Med Sch Theodor Fontane, Univ Potsdam, Brandenburg, Germany.
C3 University of Potsdam; University of Potsdam
RP Wippert, PM (corresponding author), Univ Potsdam, Med Sociol & Psychobiol, Potsdam, Germany.; Wippert, PM (corresponding author), Brandenburg Univ Technol Cottbus Senftenberg, Fac Hlth Sci Brandenburg, Brandenburg Med Sch Theodor Fontane, Univ Potsdam, Brandenburg, Germany.
EM wippert@uni-potsdam.de
RI Wippert, Pia-Maria/AAJ-6989-2020
FU Universitt Potsdam (1031)
FX We express our gratitude to Chiao-I Lin and Sanne Houtenbos for valuable
   support in proof reading.
CR Abbadie C, 2005, TRENDS IMMUNOL, V26, P529, DOI 10.1016/j.it.2005.08.001
   Aitken Leanne, 2003, Int J Nurs Pract, V9, P338, DOI 10.1046/j.1440-172X.2003.00449.x
   [Anonymous], 2012, Methods for the development of NICE public health guidance (third edition) [PMG4]
   Bablis P, 2022, J INTEGR MED-JIM, V20, P135, DOI 10.1016/j.joim.2021.12.001
   Baumgart JK, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192903
   Carney KBM, 2020, BIOL RES NURS, V22, P205, DOI 10.1177/1099800420907964
   Cheng YY, 2015, J BIOCHEM, V158, P299, DOI 10.1093/jb/mvv041
   Cho HK, 2015, EUR J INTEGR MED, V7, P118, DOI 10.1016/j.eujim.2014.10.008
   Chou R, 2017, ANN INTERN MED, V166, P493, DOI 10.7326/M16-2459
   Da Luz MA Jr, 2019, SPINE, V44, P68, DOI 10.1097/BRS.0000000000002756
   Downs SH, 1998, J EPIDEMIOL COMMUN H, V52, P377, DOI 10.1136/jech.52.6.377
   EMEA. ICH Topic E 10 Choice of Control Group in Clinical Trials, 2001, Note for Guidance on choice of control group in clinical trials
   (EPOC), 2013, CEPaOoC. Data collection form. EPOC resources for review authors
   Geneen LJ, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011279.pub3
   Gerdle B, 2020, SCAND J PAIN, V20, P125, DOI 10.1515/sjpain-2019-0088
   Hughes CE, 2018, FEBS J, V285, P2944, DOI 10.1111/febs.14466
   Jiang BC, 2020, PHARMACOL THERAPEUT, V212, DOI 10.1016/j.pharmthera.2020.107581
   Khan AN, 2017, ANN NY ACAD SCI, V1410, P68, DOI 10.1111/nyas.13551
   Kim B, 2020, TOHOKU J EXP MED, V251, P193, DOI 10.1620/tjem.251.193
   Koch A, 2007, INFLAMM RES, V56, P32, DOI 10.1007/s00011-007-6088-4
   Koechlin H, 2019, SYST REV-LONDON, V8, DOI 10.1186/s13643-019-1174-6
   Lamichhane B, 2021, NEUROIMAGE-CLIN, V29, DOI 10.1016/j.nicl.2020.102530
   Li Y, 2016, BIOSCIENCE REP, V36, DOI 10.1042/BSR20160187
   Licciardone JC, 2012, J AM OSTEOPATH ASSOC, V112, P596, DOI 10.7556/jaoa.2012.112.9.596
   Lin WC, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/103570
   Livingston JD, 2012, ADDICTION, V107, P39, DOI 10.1111/j.1360-0443.2011.03601.x
   Maher C, 2017, LANCET, V389, P736, DOI 10.1016/S0140-6736(16)30970-9
   Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
   Morris P, 2020, BMC MUSCULOSKEL DIS, V21, DOI 10.1186/s12891-020-3154-3
   Nambi G, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000023555
   Nicholas M, 2019, PAIN, V160, P28, DOI 10.1097/j.pain.0000000000001390
   Owen PJ, 2020, BRIT J SPORT MED, V54, P1279, DOI 10.1136/bjsports-2019-100886
   Perrot S, 2019, PAIN, V160, P77, DOI 10.1097/j.pain.0000000000001389
   Poojari S, Effectiveness of Integrated Approach of Yoga Therapy (IAYT) Versus Usual Care in Management on Chronic Low Back Pain patients: a Randomized Controlled Pilot Study2021
   Roy RA, 2010, J CHIROPR MED, V9, P107, DOI 10.1016/j.jcm.2010.06.002
   Sadjapong U, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17113760
   Sanada K, 2015, ARTHRITIS RES THER, V17, DOI 10.1186/s13075-015-0789-9
   Sterne JAC, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l4898
   Sterne JAC, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i4919
   Teodorczyk-Injeyan JA, 2021, CHIROPR MAN THER, V29, DOI 10.1186/s12998-020-00357-y
   Teodorczyk-Injeyan JA, 2018, CLIN J PAIN, V34, P68, DOI 10.1097/AJP.0000000000000507
   Teodorczyk-Injeyan JA, 2011, J MANIP PHYSIOL THER, V34, P498, DOI 10.1016/j.jmpt.2011.08.010
   van den Berg R, 2018, SPINE J, V18, P2140, DOI 10.1016/j.spinee.2018.06.349
   Vanderwall AG, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.03009
   von der Lippe E, 2021, RESULTS BURDEN 2020, P1
   Waddell G., 2004, BACK PAIN REVOLUTION, V2nd
   Wang H., 2005, Eur Cells Mater, V10, P33
   Wang H, 2008, CLIN J PAIN, V24, P273, DOI 10.1097/AJP.0b013e31816111d3
   Wang Z, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1309751
   Windsor MT, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00203
   Wood L, 2019, EUR J PAIN, V23, P234, DOI 10.1002/ejp.1314
   Yeh CH, 2014, MED ACUPUNCT, V26, P31, DOI 10.1089/acu.2013.1015
   Yucesoy H, 2021, INT J BIOMETEOROL, V65, P1367, DOI 10.1007/s00484-021-02109-w
   Zgierska AE, 2016, PAIN MED, V17, P1865, DOI 10.1093/pm/pnw006
   Zhang JM, 2007, INT ANESTHESIOL CLIN, V45, P27, DOI 10.1097/AIA.0b013e318034194e
   Zick SM, 2020, PAIN REP, V5, DOI 10.1097/PR9.0000000000000837
NR 56
TC 7
Z9 7
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD MAR 8
PY 2024
VL 25
IS 1
AR 209
DI 10.1186/s12891-024-07289-1
PG 14
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA KP9K8
UT WOS:001181286900002
PM 38459458
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Melo, RNR
   Francisco, SC
   Moura, CD
   Loudon, K
   Sawada, NO
   Chave, EDL
   Chianca, TCM
   Nogueira, DA
   Zhu, SJ
   Garcia, ACM
AF Rodrigues Melo, Ruan Nilton
   Francisco, Stephanie Carolina
   Moura, Caroline de Castro
   Loudon, Kirsty
   Sawada, Namie Okino
   Lopes Chave, Erika de Cassia
   Machado Chianca, Tania Couto
   Nogueira, Denismar Alves
   Zhu, Si Jia
   Mesquita Garcia, Ana Claudia
TI Auriculotherapy to control chemotherapy-induced nausea and vomiting in
   patients with cancer: protocol of a systematic review
SO SYSTEMATIC REVIEWS
LA English
DT Review
DE Nausea; Vomiting; Drug therapy; Neoplasms; Auricular acupuncture;
   Systematic review
ID ACUPRESSURE; MANAGEMENT; ACUPUNCTURE; PAIN
AB Background Due to the worldwide rise in cancer incidence, and therefore the rise in the need for antineoplastic chemotherapy, it is important for both healthcare professionals and patients alike that the side effects of chemotherapy, such as chemotherapy-induced nausea and vomiting (CINV), are treated and prevented. Auriculotherapy is a type of acupuncture and may be a low-cost and safe antiemetic measure to control the side effects of chemotherapy. The goal of this systematic review is to synthesize the available evidence in the literature regarding the auriculotherapy effects to treat CINV in people with cancer. Methods The review will only include randomized controlled trials (RCTs) that compare the clinical effects of the auriculotherapy intervention (used alone or as an add-on), with sham auriculotherapy, routine treatment with antiemetic drugs, or other non-pharmacological interventions in patients with cancer with CINV who are undergoing chemotherapy. The outcomes to be evaluated are nausea and vomiting: in acute, delayed, or anticipated stages, when induced by chemotherapy. A comprehensive search for studies will be carried out in these databases: MEDLINE via PubMed, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, ICTRP, LILACS, CUMED, IBECS, BVS MTCI Americas, Web of Science, Scopus, PEDro, CNKI, and CBMdisc up until December 31, 2018. Only articles in English, Portuguese, and Spanish will be selected. Two independent reviewers will evaluate full texts, extract data, and assess the risk of bias of eligible articles. The quality of evidence will be assessed using Grading of Recommendations, Assessment, Development and Evaluation (GRADE). A meta-analysis will be undertaken to assess the interventions and outcomes' homogeneity, assessing statistical heterogeneity using the Cochran's Q test and quantified using Higgins' inconsistency index. If there is insufficient data for a meta-analysis, a narrative synthesis will be presented. This protocol has been prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. Discussion The results of this systematic review will summarize the strength of evidence for the use of auriculotherapy in the control of CINV of patients with cancer and will be used to identify evidence gaps. Systematic review registration PROSPERO CRD42018117513
C1 [Rodrigues Melo, Ruan Nilton; Francisco, Stephanie Carolina; Lopes Chave, Erika de Cassia; Mesquita Garcia, Ana Claudia] Univ Fed Alfenas, Sch Nursing, Gabriel Monteiro Silva St,700 Ctr, BR-30130100 Alfenas, MG, Brazil.
   [Moura, Caroline de Castro; Machado Chianca, Tania Couto] Univ Fed Minas Gerais, Sch Nursing, Prof Alfredo Balena Ave 190, BR-37130001 Belo Horizonte, MG, Brazil.
   [Sawada, Namie Okino] Univ Sao Paulo, Ribeirao Preto Coll Nursing, Bandeirantes Ave 3900 Univ Campus Monte Alegre, BR-14040900 Ribeirao Preto, SP, Brazil.
   [Nogueira, Denismar Alves] Univ Fed Alfenas, Inst Exact Sci, Gabriel Monteiro Silva St 700 Ctr, BR-37130001 Alfenas, MG, Brazil.
   [Zhu, Si Jia] Beijing Univ Chinese Med BUCM China, Ctr Evidence Based Med, East Rd 11 North Third Ring Rd, Beijing 1000029, Peoples R China.
C3 Universidade Federal de Alfenas; Universidade Federal de Minas Gerais;
   Universidade de Sao Paulo; Universidade Federal de Alfenas
RP Garcia, ACM (corresponding author), Univ Fed Alfenas, Sch Nursing, Gabriel Monteiro Silva St,700 Ctr, BR-30130100 Alfenas, MG, Brazil.
EM ana.mesquita@unifal-mg.edu.br
RI Loudon, Kirsty/A-1951-2019; de Castro Moura, Caroline/AAM-9293-2021;
   Chianca, Tania/ABI-1404-2020; Mesquita Garcia, Ana
   Cláudia/AAL-2737-2021; A Nogueira, Denismar/A-6605-2017; Melo,
   Ruan/OPN-6953-2025; Sawada, Namie Okino/C-6112-2012
OI Loudon, Kirsty/0000-0002-4449-6226; de Castro Moura,
   Caroline/0000-0003-1224-7177; Mesquita Garcia, Ana
   Cláudia/0000-0001-9793-7905; A Nogueira, Denismar/0000-0003-2285-8764;
   Sawada, Namie Okino/0000-0002-1874-3481
CR [Anonymous], 2018, NCCN clinical practice guidelines in oncology (NCCN GuidelinesREG;): breast cancer version 2
   [Anonymous], 2017, Am. J. Manag. Care
   Aslam Sadaf, 2010, Indian J Sex Transm Dis AIDS, V31, P47, DOI 10.4103/0253-7184.69003
   Booth A, 2012, SYST REV-LONDON, V1, DOI 10.1186/2046-4053-1-2
   Booth A, 2011, LANCET, V377, P108, DOI 10.1016/S0140-6736(10)60903-8
   do Prado JM, 2018, REV ESC ENFERM USP, V52, DOI [10.1590/S1980-220X2017030403334, 10.1590/s1980-220x2017030403334]
   Eghbali M, 2016, COMPLEMENT THER CLIN, V24, P189, DOI 10.1016/j.ctcp.2016.06.006
   Fernández-Ortega P, 2012, SUPPORT CARE CANCER, V20, P3141, DOI 10.1007/s00520-012-1448-1
   Gori L, 2007, EVID-BASED COMPL ALT, V4, P13, DOI 10.1093/ecam/nem106
   Grunberg Steven M, 2004, J Support Oncol, V2, P1
   Guyatt GH, 2011, J CLIN EPIDEMIOL, V64, P380, DOI 10.1016/j.jclinepi.2010.09.011
   Higgins JPT, 2002, STAT MED, V21, P1539, DOI [10.1002/sim.1186, 10.1016/j.bandl.2008.10.005]
   Higgins Julian P T, 2011, BMJ, V343, pd5928, DOI 10.1136/bmj.d5928
   Hou PW, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/495684
   Inoue M, 2015, BMC PHARMACOL TOXICO, V16, DOI 10.1186/s40360-015-0005-1
   Janelsins MC, 2013, EXPERT OPIN PHARMACO, V14, P757, DOI 10.1517/14656566.2013.776541
   Lee EJ, 2011, J PAIN SYMPTOM MANAG, V42, P589, DOI 10.1016/j.jpainsymman.2011.01.007
   Lewis S, 2001, BMJ-BRIT MED J, V322, P1479, DOI 10.1136/bmj.322.7300.1479
   Liau CT, 2005, SUPPORT CARE CANCER, V13, P277, DOI 10.1007/s00520-005-0788-5
   Macdonald G, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001930.pub3
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Mafetoni RR, 2016, REV ESC ENFERM USP, V50, P726, DOI [10.1590/S0080-623420160000600003, 10.1590/s0080-623420160000600003]
   McGlinchey MP, 2018, SYST REV-LONDON, V7, DOI 10.1186/s13643-018-0870-y
   Mercante B, 2018, MED ACUPUNCT, V30, P141, DOI 10.1089/acu.2017.1254
   Miao J, 2017, INT J NURS STUD, V70, P27, DOI 10.1016/j.ijnurstu.2017.02.014
   Minami M, 2003, PHARMACOL THERAPEUT, V99, P149, DOI 10.1016/S0163-7258(03)00057-3
   Moore CB, 2017, J PERIANESTH NURS, V32, P96, DOI 10.1016/j.jopan.2015.06.006
   Moradian S, 2015, INT J PALLIAT NURS, V21, P216, DOI 10.12968/ijpn.2015.21.5.216
   Moura CD, 2018, REV LAT-AM ENFERM, V26, DOI 10.1590/1518-8345.2678.3050
   Mustian Karen M, 2011, US Oncol Hematol, V7, P91
   Natale James J, 2015, Hosp Pract (1995), V43, P226, DOI [10.1080/21548331.2015.1077095, 10.1080/21548331.2015.1077095]
   Ogilvie D, 2008, BMC MED RES METHODOL, V8, DOI 10.1186/1471-2288-8-8
   Paley CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub3
   Parsa-Yekta Z., 2012, Razi Journal of Medical Sciences, V18, P33
   Rabischong P, 2014, MED ACUPUNCT, V26, P84, DOI 10.1089/acu.2014.1038
   Ren RY, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000014621
   Round R., 2013, EVID-BASED COMPL ALT, V2013, P984763, DOI DOI 10.1155/2013/984763
   Kurebayashi LFS, 2015, REV BRAS ENFERM, V68, P109, DOI 10.1590/0034-7167.2015680116p
   Schwarzer G., 2007, R News, V7, P40
   Shamseer L, 2015, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g7647
   Sommariva S, 2016, CRIT REV ONCOL HEMAT, V99, P13, DOI 10.1016/j.critrevonc.2015.12.001
   Taspinar A, 2010, EUR J ONCOL NURS, V14, P49, DOI 10.1016/j.ejon.2009.07.006
   Tipton Janelle M, 2007, Clin J Oncol Nurs, V11, P69, DOI 10.1188/07.CJON.69-78
   Torres CH, 2015, SUPPORT CARE CANCER, V23, P3341, DOI 10.1007/s00520-015-2801-y
   Vidall C, 2011, ECANCERMEDICALSCIENC, V5, DOI 10.3332/ecancer.2011.211
   Wood JM, 2011, CANCER NURS, V34, pE14, DOI 10.1097/NCC.0b013e3181e2cd79
   Yeh Chao Hsing, 2014, Evid Based Complement Alternat Med, V2014, P375173, DOI 10.1155/2014/375173
   Zhao HJ, 2015, COMPLEMENT THER CLIN, V21, P68, DOI 10.1016/j.ctcp.2015.03.006
NR 48
TC 4
Z9 5
U1 2
U2 27
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2046-4053
J9 SYST REV-LONDON
JI Syst. Rev.
PD AUG 15
PY 2019
VL 8
IS 1
AR 206
DI 10.1186/s13643-019-1124-3
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IS0MJ
UT WOS:000481844200002
PM 31416474
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lu, C
   Bao, WL
   Deng, DH
   Li, RR
   Li, GL
   Zou, SL
   Wang, Y
AF Lu, Chao
   Bao, Wenlong
   Deng, Dehou
   Li, Rongrong
   Li, Guangliang
   Zou, Shanlin
   Wang, Yan
TI Efficacy of electroacupuncture with different frequencies in the
   treatment of chemotherapy-induced peripheral neuropathy: A study
   protocol for a randomized controlled trial
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE electroacupuncture; chemotherapy-induced peripheral neuropathy;
   randomized controlled trial; protocol; Mecobalamin
ID NERVE-CONDUCTION; CLINICAL-TRIALS; ACUPUNCTURE; MANAGEMENT; CANCER;
   DIAGNOSIS
AB Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication in patients with cancer during chemotherapy. It mainly leads to severe numbness of the hands and feet and causes great pain in patients. Electroacupuncture (EA) is considered to be beneficial in improving peripheral neuropathy and relieving numbness of the hands and feet. This trial aims to evaluate the therapeutic effect of different frequencies of EA on CIPN in patients with cancer. Methods and analysis: This study is a randomized controlled trial. In total, 160 eligible CIPN patients are randomly assigned to the 2 Hz EA group, 100 Hz EA group, 2/100 Hz EA group, and control group in the ratio of 1:1:1:1. All patients in the EA treatment groups receive treatment with EA three times a week for 4 weeks and following up for 4 weeks. The patients in the control group are given Mecobalamin (MeCbl) tablets orally, one tablet at a time, three times a day, for 4 weeks, and following up for 4 weeks. The primary outcome measures are the participant neurotoxicity questionnaire (PNQ) and the peripheral neurotoxicity assessment rating (NCI CTCAE V5.0). Secondary outcomes are the quality of life scale (EORTC QLQ-C30) and the measurement of peripheral nerve conduction velocity (NCV). The results are evaluated at baseline, post-treatment phase, and following up for 4 weeks. All major analyses are based on the intention to treat principle. Ethics/dissemination: This protocol was approved by the Medical Ethics Committee of the Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) on 7 December 2021. The license number is IRB-2021-458. This study provides clinical efficacy data of different frequencies of EA in the treatment of CIPN. The results help to prove whether EA is an effective therapy for CIPN and optimize the frequency of EA for CIPN. The results of this study are shared with health care professionals, the public, and relevant organizations through the publication of manuscripts and conference reports.
C1 [Lu, Chao; Bao, Wenlong; Deng, Dehou; Zou, Shanlin; Wang, Yan] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Tradit Chinese Med Dept, Canc Hosp, Hangzhou, Peoples R China.
   [Li, Rongrong] Zhejiang Univ Tradit Chinese Med, Clin Med Coll 3, Hangzhou, Peoples R China.
   [Li, Guangliang] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Breast Med Oncol Dept, Canc Hosp, Hangzhou, Peoples R China.
C3 Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS; Zhejiang Cancer Hospital; Zhejiang Chinese Medical University;
   Zhejiang Cancer Hospital; Chinese Academy of Sciences; University of
   Chinese Academy of Sciences, CAS
RP Lu, C (corresponding author), Univ Chinese Acad Sci, Zhejiang Canc Hosp, Tradit Chinese Med Dept, Canc Hosp, Hangzhou, Peoples R China.
EM 1069103617@qq.com
RI Lu, Chao/ODK-2866-2025; Li, Guangliang/B-6715-2011; Li,
   Rongrong/B-8365-2019
OI Lu, Chao/0000-0002-0762-5797; 
FU Program of Science Research Foundation of Zhejiang Provincial TCM
   Administration;  [2022ZB058]
FX The work was supported by the Program of Science Research Foundation of
   Zhejiang Provincial TCM Administration (2022ZB058).
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   AL-Atiyyat N, 2017, INT J PALLIAT NURS, V23, P13, DOI 10.12968/ijpn.2017.23.1.13
   Basch E, 2014, JNCI-J NATL CANCER I, V106, DOI 10.1093/jnci/dju244
   Carvalho LF, 2017, CLIN EXP PHARMACOL P, V44, P971, DOI 10.1111/1440-1681.12803
   Cavaletti G, 2007, J PERIPHER NERV SYST, V12, P210, DOI 10.1111/j.1529-8027.2007.00141.x
   Chan AW, 2013, ANN INTERN MED, V158, P200, DOI 10.7326/0003-4819-158-3-201302050-00583
   [崔光卫 Cui Guangwei], 2017, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V32, P2670
   Domkundwar S, 2017, J ULTRASOUND, V20, P111, DOI 10.1007/s40477-016-0232-3
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Franconi G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/516916
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   Han YJ, 2018, MINERVA ENDOCRINOL, V43, P11, DOI 10.23736/S0391-1977.16.02505-0
   Hausheer FH, 2006, SEMIN ONCOL, V33, P15, DOI 10.1053/j.seminoncol.2005.12.010
   Hwang MS, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019837
   Jiang DQ, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011390
   Lee JS, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-124
   Lee S, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-225
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   MacPherson H, 2010, ACUPUNCT MED, V28, P83, DOI 10.1136/aim.2009.001370
   McCrary JM, 2017, SUPPORT CARE CANCER, V25, P3485, DOI 10.1007/s00520-017-3772-y
   Meng XZ, 2011, BRAIN RES, V1414, P58, DOI 10.1016/j.brainres.2011.08.004
   Park SB, 2009, J CLIN ONCOL, V27, P1243, DOI 10.1200/JCO.2008.19.3425
   Renn CL, 2011, MOL PAIN, V7, DOI 10.1186/1744-8069-7-29
   Sawangjit R, 2020, J ALTERN COMPLEM MED, V26, P1117, DOI 10.1089/acm.2020.0068
   Schröder S, 2007, EUR J NEUROL, V14, P276, DOI 10.1111/j.1468-1331.2006.01632.x
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Shimozuma K, 2012, SUPPORT CARE CANCER, V20, P3355, DOI 10.1007/s00520-012-1492-x
   Shimozuma K, 2009, SUPPORT CARE CANCER, V17, P1483, DOI 10.1007/s00520-009-0613-7
   Sun XJ, 2012, Shanghai J Acupunct Moxibustion, V31, P727, DOI DOI 10.3969/J.ISSN.1005-0957.2012.10.727
   Tsubaki M, 2015, INT J CANCER, V137, P243, DOI 10.1002/ijc.29367
   Wozniak KM, 2018, CANCER RES, V78, P817, DOI 10.1158/0008-5472.CAN-17-1467
   Wozniak KM, 2016, CANCER RES, V76, P3332, DOI 10.1158/0008-5472.CAN-15-2525
   Xiang Y., 2018, Chin J Integr Med Cardio-/Cerebrovasc Dis, V16, P1168
   Xiaobing C., 2012, CHIN MED PHARM, V2, P38
   Yokoyama S, 2022, SUPPORT CARE CANCER, V30, P1765, DOI 10.1007/s00520-021-06585-z
   Yuanyuan L., 2019, J ZHEJIANG CHIN MED, V43, DOI [10.16466/j.issn1005-5509.2019.05.024, DOI 10.16466/J.ISSN1005-5509.2019.05.024]
   Zajaczkowska R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061451
   Zhang M, 2013, NEURAL PLAST, V2013, DOI 10.1155/2013/424651
NR 39
TC 8
Z9 8
U1 2
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD JUL 28
PY 2022
VL 13
AR 843886
DI 10.3389/fneur.2022.843886
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 3S1CX
UT WOS:000839341600001
PM 35968286
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Abe, H
   Inoue, R
   Tsuchida, R
   Ando, M
   Saita, K
   Konishi, M
   Edamura, T
   Ogawa, A
   Matsuoka, Y
   Sumitani, M
AF Abe, Hiroaki
   Inoue, Reo
   Tsuchida, Rikuhei
   Ando, Masae
   Saita, Kosuke
   Konishi, Mitsuru
   Edamura, Tatsuma
   Ogawa, Asao
   Matsuoka, Yutaka
   Sumitani, Masahiko
TI Efficacy of treatments for pain and numbness in cancer survivors: a
   systematic review and meta-analysis
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Review; Early Access
DE Meta-analysis; cancer survivors; pain; numbness; treatment
ID INDUCED PERIPHERAL NEUROPATHY; QUALITY-OF-LIFE; RANDOMIZED
   CONTROLLED-TRIAL; INHIBITOR-ASSOCIATED ARTHRALGIA; LOW-BACK-PAIN;
   MUSCULOSKELETAL SYMPTOMS; EXERCISE INTERVENTION; AMERICAN SOCIETY;
   PHYSICAL-THERAPY; TRIGGER POINTS
AB Background: Pain and numbness in cancer survivors frequently have negative impacts on quality of life (QoL). This meta-analysis aimed to identify the current treatment options for pain and numbness in cancer survivors and to evaluate their effects.Methods: Cancer survivors were defined as patients diagnosed with cancer who had completed active cancer treatment, whose conditions were stable, and who had no evidence of recurrent or progressive disease. A systematic search through the PubMed, MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Web of Science, PsycInfo, and CINAHL databases was conducted, which targeted randomized controlled trials (RCTs) published until April 2022 that evaluated any type of treatment for pain or numbness in cancer survivors. A meta-analysis was conducted using the random-effects model to obtain the effect sizes of 7 types of treatments: opioid therapy, nonopioid pharmacotherapy, interventional therapy, acupuncture, education/cognitive behavioral therapy (CBT), physical exercise, and alternative medicine.Results: A total of 36 studies involving 2,870 cancer survivors were included. Among them, 35 (n=2,813) were included in the meta-analysis for pain. The analysis suggested that physical exercise [n=761; 13 studies; standardized mean difference (SMD) -0.84; 95% confidence interval (CI): -1.14 to -0.55], acupuncture (n=409; 3 studies; SMD -0.80; 95% CI: -1.04 to -0.56), and alternative medicine (n=206; 6 studies; SMD -0.44; 95% CI: -0.71 to -0.16) could significantly reduce pain. Nonopioid pharmacotherapy and education/ CBT did not demonstrate significant effects. No studies were identified that investigated the effects of opioid therapy or interventional therapy on pain. Regarding numbness, 5 studies (n=566) were included in the meta analysis. Acupuncture (n=99; 2 studies) did not demonstrate significant effects on numbness, and the effects of nonopioid pharmacotherapy, education/CBT, and physical exercise could not be determined due to the small number of included studies. No studies were identified that investigated the effects of opioid therapy, interventional therapy, or alternative medicine on numbness.Conclusions: This meta-analysis suggested that physical exercise, acupuncture, and alternative medicine may reduce pain in cancer survivors, with a very small to moderate amount of evidence. The effect of treatments for numbness could not be determined due to the limited number of included studies. Further studies are needed, particularly on widely used pharmacotherapy.
C1 [Abe, Hiroaki; Konishi, Mitsuru; Sumitani, Masahiko] Univ Tokyo Hosp, Dept Pain & Palliat Med, Tokyo, Japan.
   [Inoue, Reo; Tsuchida, Rikuhei; Ando, Masae; Saita, Kosuke; Edamura, Tatsuma] Univ Tokyo Hosp, Pain Relief Ctr, Dept Anesthesiol, Tokyo, Japan.
   [Ogawa, Asao] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Tokyo, Japan.
   [Matsuoka, Yutaka] Natl Canc Ctr, Ctr Publ Hlth Sci, Tokyo, Japan.
   [Sumitani, Masahiko] Univ Tokyo Hosp, Dept Pain & Palliat Med, 7-3-1 Hongo, Bunkyo, Tokyo 1138655, Japan.
C3 University of Tokyo; University of Tokyo; National Cancer Center -
   Japan; National Cancer Center - Japan
RP Sumitani, M (corresponding author), Univ Tokyo Hosp, Dept Pain & Palliat Med, 7-3-1 Hongo, Bunkyo, Tokyo 1138655, Japan.
EM SUMITANIM-ANE@h.u-tokyo.ac.jp
RI Matsuoka, Yutaka/LEM-8619-2024
FU National Cancer Center Research and Development Fund;  [30-A-17]; 
   [2021-A-17]; Grants-in-Aid for Scientific Research [20K10461] Funding
   Source: KAKEN
FX Funding : This research was supported by the National Cancer Center
   Research and Development Fund (Nos. 30-A-17 and 2021-A-17) .
CR Alberts NM, 2020, JCO CLIN CANCER INFO, V4, P1014, DOI 10.1200/CCI.20.00070
   Aziz NM, 2003, SEMIN RADIAT ONCOL, V13, P248, DOI 10.1016/S1053-4296(03)00024-9
   Baglia ML, 2019, CANCER-AM CANCER SOC, V125, P2262, DOI 10.1002/cncr.32051
   Balshem H, 2011, J CLIN EPIDEMIOL, V64, P401, DOI 10.1016/j.jclinepi.2010.07.015
   Bao T, 2021, ONCOLOGIST, V26, pE2070, DOI 10.1002/onco.13933
   Bao T, 2020, JNCI CANCER SPECT, V4, DOI 10.1093/jncics/pkaa048
   Boing L, 2020, MATURITAS, V141, P71, DOI 10.1016/j.maturitas.2020.06.022
   Burch JB, 2020, APPL PSYCHOPHYS BIOF, V45, P99, DOI 10.1007/s10484-020-09462-3
   Burton AW, 2007, PAIN MED, V8, P189, DOI 10.1111/j.1526-4637.2006.00220.x
   Cantarero-Villanueva I, 2017, PAIN MED, V18, P1366, DOI 10.1093/pm/pnx026
   Cantarero-Villanueva I, 2012, PAIN MED, V13, P1509, DOI 10.1111/j.1526-4637.2012.01481.x
   Castro-Martín E, 2017, ARCH PHYS MED REHAB, V98, P832, DOI 10.1016/j.apmr.2016.11.019
   Chen ZY, 2021, COMPLEMENT THER MED, V59, DOI 10.1016/j.ctim.2021.102737
   Cochrane Training, 2022, Cochrane Handbook for Systematic Reviews of Interventions
   Conejo I, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2236-3
   Couto N, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-14213-x
   Cramer JD, 2018, OTOLARYNG HEAD NECK, V159, P853, DOI 10.1177/0194599818783964
   Crew Katherine D, 2007, J Cancer Surviv, V1, P283, DOI 10.1007/s11764-007-0034-x
   da Silva FP, 2019, J MANIP PHYSIOL THER, V42, P503, DOI 10.1016/j.jmpt.2018.12.007
   De Groef A, 2018, CLIN REHABIL, V32, P451, DOI 10.1177/0269215517730863
   De Groef A, 2018, ARCH PHYS MED REHAB, V99, P1342, DOI 10.1016/j.apmr.2017.12.032
   Denlinger CS, 2014, J NATL COMPR CANC NE, V12, P488, DOI 10.6004/jnccn.2014.0054
   Sosa-Reina MD, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/2356346
   Eaton LH, 2021, INT J CLIN EXP HYP, V69, P422, DOI 10.1080/00207144.2021.1951119
   Ellison N, 1997, J CLIN ONCOL, V15, P2974, DOI 10.1200/JCO.1997.15.8.2974
   Fernández-Lao C, 2012, CLIN J PAIN, V28, P113, DOI 10.1097/AJP.0b013e318225dc02
   Fields J, 2016, J PAIN SYMPTOM MANAG, V52, P548, DOI 10.1016/j.jpainsymman.2016.03.010
   Fu MR, 2022, JMIR CANCER, V8, DOI 10.2196/29485
   Galiano-Castillo N, 2016, CANCER-AM CANCER SOC, V122, P3166, DOI 10.1002/cncr.30172
   Gewandter JS, 2014, SUPPORT CARE CANCER, V22, P1807, DOI 10.1007/s00520-014-2158-7
   Glare PA, 2014, J CLIN ONCOL, V32, P1739, DOI 10.1200/JCO.2013.52.4629
   Haddad AR, 2021, WORLD NEUROSURG, V151, P225, DOI 10.1016/j.wneu.2021.04.075
   Hamood R, 2018, BREAST CANCER RES TR, V167, P157, DOI 10.1007/s10549-017-4485-0
   Hayden JA, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD000335.pub2
   Hayden JA, 2021, J PHYSIOTHER, V67, P252, DOI 10.1016/j.jphys.2021.09.004
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928
   Hilton L, 2017, ANN BEHAV MED, V51, P199, DOI 10.1007/s12160-016-9844-2
   Irwin ML, 2015, J CLIN ONCOL, V33, P1104, DOI 10.1200/JCO.2014.57.1547
   Izquierdo-Alventosa R, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17103634
   Jairam V, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.13605
   Jiang JR, 2019, J CLIN ONCOL, V37, P135, DOI 10.1200/JCO.18.00896
   Kelleher SA, 2021, SUPPORT CARE CANCER, V29, P5361, DOI 10.1007/s00520-021-06126-8
   Kim YH, 2017, OBSTET GYNECOL, V129, P870, DOI 10.1097/AOG.0000000000001988
   Lengacher CA, 2016, J CLIN ONCOL, V34, P2827, DOI 10.1200/JCO.2015.65.7874
   Limakatso K, 2020, PLOS ONE, V15, DOI [10.1101/19008961, 10.1371/journal.pone.0240431]
   Lu GL, 2020, SUPPORT CARE CANCER, V28, P1587, DOI 10.1007/s00520-019-05186-1
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Makary MM, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18870-1
   Mao JJ, 2021, JAMA ONCOL, V7, P720, DOI 10.1001/jamaoncol.2021.0310
   McNeely ML, 2008, CANCER, V113, P214, DOI 10.1002/cncr.23536
   Mishra SI, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007566.pub2
   Mols F, 2014, SUPPORT CARE CANCER, V22, P2261, DOI 10.1007/s00520-014-2255-7
   Mols F, 2013, J CLIN ONCOL, V31, P2699, DOI 10.1200/JCO.2013.49.1514
   Mu JL, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013814
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Nyrop KA, 2017, ONCOLOGIST, V22, P1238, DOI 10.1634/theoncologist.2017-0174
   O'Riordan C, 2014, ARCH PHYS MED REHAB, V95, P770, DOI 10.1016/j.apmr.2013.11.015
   Paice JA, 2016, J CLIN ONCOL, V34, P3325, DOI 10.1200/JCO.2016.68.5206
   Patel K, 2020, EUR J PAIN, V24, P1440, DOI 10.1002/ejp.1612
   Paulo TRS, 2019, HEALTH QUAL LIFE OUT, V17, DOI 10.1186/s12955-019-1090-4
   Peng N, 2018, BREAST, V37, P18, DOI 10.1016/j.breast.2017.08.003
   Piras A, 2021, EUR REV MED PHARMACO, V25, P3647, DOI 10.26355/eurrev_202105_25930
   Prinsloo S, 2017, CANCER-AM CANCER SOC, V123, P1989, DOI 10.1002/cncr.30649
   Rangon FB, 2018, J BODYW MOV THER, V22, P69, DOI 10.1016/j.jbmt.2017.04.005
   Roberts KE, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012988.pub2
   Rogers ML, 2000, EUR J CARDIO-THORAC, V18, P711, DOI 10.1016/S1010-7940(00)00569-8
   Rowland J. H., 2011, Morbidity and Mortality Weekly Report, V60, P269
   Salehifar E, 2020, CLIN DRUG INVEST, V40, P249, DOI 10.1007/s40261-019-00882-6
   Sanford NN, 2019, CANCER-AM CANCER SOC, V125, P4310, DOI 10.1002/cncr.32450
   Serra-Añó P, 2019, SUPPORT CARE CANCER, V27, P2633, DOI 10.1007/s00520-018-4544-z
   Shapiro AC, 2016, BREAST CANCER RES TR, V155, P501, DOI 10.1007/s10549-016-3710-6
   Shergill Y, 2022, PAIN RES MANAG, V2022, DOI 10.1155/2022/4020550
   Sielski R, 2017, INT J BEHAV MED, V24, P25, DOI 10.1007/s12529-016-9572-9
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Smith SK, 2019, SUPPORT CARE CANCER, V27, P1775, DOI 10.1007/s00520-018-4431-7
   Tanabe Y, 2013, INT J CLIN ONCOL, V18, P132, DOI 10.1007/s10147-011-0352-x
   Tekur P, 2012, COMPLEMENT THER MED, V20, P107, DOI 10.1016/j.ctim.2011.12.009
   Tsai CL, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-94466-0
   Ughreja RA, 2021, COMPLEMENT THER CLIN, V45, DOI 10.1016/j.ctcp.2021.101477
   Valenza MC, 2017, CLIN REHABIL, V31, P753, DOI 10.1177/0269215516651978
   van den Beuken-van Everdingen MHJ, 2016, J PAIN SYMPTOM MANAG, V51, P1070, DOI 10.1016/j.jpainsymman.2015.12.340
   Wan X, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-135
   Wang L, 2021, CLIN REHABIL, V35, P342, DOI 10.1177/0269215520968251
   Weir CJ, 2018, BMC MED RES METHODOL, V18, DOI 10.1186/s12874-018-0483-0
   Wewege MA, 2018, J BACK MUSCULOSKELET, V31, P889, DOI 10.3233/BMR-170920
   WHO, 2018, WHO GUI PHARM RAD MA
   WHO. International Agency for Research on Cancer, GLOB 2020 POP FACT S
   Wolf S, 2008, EUR J CANCER, V44, P1507, DOI 10.1016/j.ejca.2008.04.018
   Yang GS, 2017, CANCER NURS, V40, pE26, DOI 10.1097/NCC.0000000000000409
NR 91
TC 4
Z9 5
U1 0
U2 13
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD 2022 OCT 12
PY 2022
DI 10.21037/apm-22-420
EA OCT 2022
PG 23
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 6L7NE
UT WOS:000888367700001
PM 36408559
OA gold
DA 2026-01-16
ER

PT J
AU He, CJ
   Wang, T
   Gu, YF
   Tian, QH
   Zhou, B
   Wu, CG
AF He, Chengjian
   Wang, Tao
   Gu, Yifeng
   Tian, Qinghua
   Zhou, Bi
   Wu, Chungen
TI Unusual case of pyogenic spondylodiscitis, vertebral osteomyelitis and
   bilateral psoas abscesses after acupuncture: diagnosis and treatment
   with interventional management
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE INFECTIOUS DISEASES; PAIN MANAGEMENT
AB Background We report, for the first time, a case of pyogenic spondylodiscitis combined with vertebral osteomyelitis and bilateral psoas abscesses after acupuncture.
   Case history A 60-year-old man was diagnosed with rectal cancer, and radical rectectomy and permanent colostomy were carried out. However, 3years after the surgery the patient complained of pain in the lower back, and the symptoms worsened after seven sessions of acupuncture. Technetium 99m-labelled methylene diphosphonate (Tc-99m-MDP) bone scintigraphy (BS) revealed abnormal uptake of Tc-99m-MDP in the L4 and L5 vertebrae. He was admitted to our hospital because of suspected bone metastases from rectal cancer. He was diagnosed with infection based on a history of acupuncture and the findings of enhanced MRI and CT. Percutaneous lumbar discectomy (PLD), external drainage and irrigation using antibiotics were carried out to treat the L4-5 disc. Pathological analyses and bacterial culture of the resected disc confirmed infection with group C streptococcus. Postoperative antibiotic treatment resulted in significant pain relief on the third day and gradual complete relief. Considerable improvement was seen on CT and MRI at follow-up.
   Conclusions We consider it highly likely that this patient's infection was caused by acupuncture. In patients with malignancy, abnormal uptake of Tc-99m-MDP in BS may signify bone metastasis but can also be observed in bone infections. PLD can be used to resect diseased discs to relieve pain quickly and to prevent herniation of lumbar discs. After PLD, external drainage can be employed for abscess drainage, decompression and perfusion of antibiotics. PLD may serve as an alternative to open surgery for pyogenic spondylodiscitis.
C1 [He, Chengjian; Wang, Tao; Gu, Yifeng; Tian, Qinghua; Zhou, Bi; Wu, Chungen] Shanghai Jiao Tong Univ, Dept Diagnost & Intervent Radiol, Affiliated Peoples Hosp 6, Shanghai 200233, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University
RP Wu, CG (corresponding author), Shanghai Jiao Tong Univ, Dept Diagnost & Intervent Radiol, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Shanghai, Peoples R China.
EM wcgshly@163.com
OI Wu, Chungen/0000-0002-4215-4812
CR GARCIA AA, 1994, WESTERN J MED, V161, P90
   Ha GY, 1999, J CLIN MICROBIOL, V37, P1227, DOI 10.1128/JCM.37.4.1227-1228.1999
   Matsumura Y, 1998, J ORAL MAXIL SURG, V56, P495, DOI 10.1016/S0278-2391(98)90721-2
   Peuker E, 2001, Acupunct Med, V19, P103
   Rampes H, 1995, ACUPUNCT MED, V13, P26, DOI [10.1136/aim.13.1.26, DOI 10.1136/AIM.13.1.26]
   Walsh B, 2001, Acupunct Med, V19, P109
   Wiwanitkit V, 2003, COMPLEMENT THER MED, V11, P272, DOI 10.1016/S0965-2299(03)00141-9
   Woo PCY, 2001, NEW ENGL J MED, V345, P842, DOI 10.1056/NEJM200109133451119
NR 8
TC 8
Z9 12
U1 0
U2 12
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD APR
PY 2015
VL 33
IS 2
BP 154
EP 157
DI 10.1136/acupmed-2014-010717
PG 4
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CF4NQ
UT WOS:000352526800011
PM 25795295
DA 2026-01-16
ER

PT J
AU Lin, YP
   Li, YJ
   Chen, BL
   Guo, YH
AF Lin, Yong-Peng
   Li, Yong-Jin
   Chen, Bo-Lai
   Guo, Yu-Hai
TI Lumbar laminotomy and replantation for the treatment of adult spinal
   epidermoid cyst A case report
SO MEDICINE
LA English
DT Article
DE lumbar laminotomy and replantation; spinal epidermoid cysts; spinal
   tumor; surgical treatment regimen
ID PLATE FIXATION; REGION
AB Rationale: Adult spinal epidermoid cyst (SEC) is a rare tumor. Lumbar laminectomy and tumor removal was a routine surgical procedure for adult spinal epidermoid cyst according to the literature, but postoperative lumbar instability and intractable low back pain may occur. In this study, we presented a brief report of an adult lumbar epidermoid cyst and introduced another surgical approach.
   Patient concerns: This 28-year-old woman has been complaining of the severe right buttock pain and right thigh radiating pain for half a year. She had been diagnosed as sacroiliitis, spinal arthritis, and lumbar disc herniation at 3 different hospitals before coming to our hospital. And she received a variety of conservative treatments, including non-steroidal anti-inflammatory drugs, aspirin, acetaminophen, glucocorticoids, acupuncture, physical therapy, and so on. However, her pain did not diminish at all. Finally, we find a space-occupying lesion in her lumbar magnetic resonance images (MRI). The lesion was slightly low, equal, and uneven equal-low signals on T1WI. T2WI showed slightly higher, equal, and uneven equal-high signals. And a thin-rim enhancement was observed on Gd-DTPA-enhanced MRI.
   Diagnoses: Adult spinal epidermoid cyst.
   Interventions: The patient underwent a surgery of lumbar laminectomy, tumor excision, and spinous process-vertebral plate in situ replantation.
   Outcomes:Postoperative pathology prompted that the tumor was cystoid. The patient's symptoms were completely removed 1 week after surgery. Three-month postoperative MRI confirmed that the spinal epidermoid cyst had been completely removed and three-dimensional CT prompted lumbar lamina in situ. Bony fusion occurred at 6 months after the surgery.
   Lessons:Lumbar laminotomy and replantation provides an ideal option to treat adult spinal epidermoid cyst because it can completely remove the cyst and simultaneously reduce the risk of iatrogenic lumbar instability.
C1 [Lin, Yong-Peng; Li, Yong-Jin; Chen, Bo-Lai; Guo, Yu-Hai] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine
RP Chen, BL (corresponding author), Inpatient 10th Floor,111 Dade Rd, Guangzhou, Guangdong, Peoples R China.
EM chenbolai337@163.com
CR Gonzalvo A, 2009, J CLIN NEUROSCI, V16, P142, DOI 10.1016/j.jocn.2008.04.017
   Gotecha Sarang, 2014, Asian J Neurosurg, V9, P244, DOI 10.4103/1793-5482.146653
   Kikuchi K, 2000, AM J NEURORADIOL, V21, P1164
   Li KP, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004913
   Liu H, 2012, J CLIN NEUROSCI, V19, P712, DOI 10.1016/j.jocn.2011.07.046
   Morimoto D, 2012, J NIPPON MED SCH, V79, P327, DOI 10.1272/jnms.79.327
   Nong LM, 2015, COMPUT METHOD BIOMEC, V18, P1753, DOI 10.1080/10255842.2014.953491
   Pandey Sharad, 2015, Asian J Neurosurg, V10, P133, DOI [10.4103/1793-5482.161181, 10.4103/1793-5482.161181]
   Park Min Ho, 2014, Korean J Spine, V11, P195, DOI 10.14245/kjs.2014.11.3.195
   Seif Bahram, 2017, Adv Biomed Res, V6, P16, DOI [10.4103/2277-9175.200791, 10.4103/2277-9175.200791]
   Shah A, 2016, J CRANIOVERTEBRAL JU, V7, P59, DOI 10.4103/0974-8237.176627
   Singh Kulwant, 2016, Surg Neurol Int, V7, pS67, DOI [10.4103/2152-7806.174890, 10.4103/2152-7806.174890]
   Street JT, 2012, SPINE J, V12, P22, DOI 10.1016/j.spinee.2011.12.003
   Zhou D, 2013, EXP THER MED, V6, P596, DOI 10.3892/etm.2013.1170
   Zhu YJ, 2015, NEUROSURG FOCUS, V39, DOI 10.3171/2015.5.FOCUS15182
   Ziv ET, 2004, SPINE, V29, pE15, DOI 10.1097/01.BRS.0000104118.07839.44
NR 16
TC 6
Z9 7
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2018
VL 97
IS 1
AR e9334
DI 10.1097/MD.0000000000009334
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FU8CQ
UT WOS:000424080300011
PM 29505514
OA gold
DA 2026-01-16
ER

PT J
AU Chen, VE
   Greenberger, BA
   Shi, Z
   Gajjar, S
   Shi, WY
   Mourad, WF
   Yan, WS
AF Chen, Victor E.
   Greenberger, Benjamin A.
   Shi, Zheng
   Gajjar, Shefali
   Shi, Wenyin
   Mourad, Waleed F.
   Yan, Weisi
TI Post-mastectomy and post-breast conservation surgery pain syndrome: a
   review of etiologies, risk prediction, and trends in management
SO TRANSLATIONAL CANCER RESEARCH
LA English
DT Review
DE Etiology; detection; early predictor; acupuncture; narrative medicine
ID SENTINEL LYMPH-NODE; QUALITY-OF-LIFE; INHIBITOR-INDUCED ARTHRALGIA;
   NEUROPATHIC PAIN; PERSISTENT PAIN; AXILLARY DISSECTION; POSTOPERATIVE
   BREAST; AMERICAN SOCIETY; CANCER-TREATMENT; WOMEN
AB Postmastectomy pain syndrome (PMPS) or breast conservation surgery (BCS) pain syndrome could be long-term and lead to disability and impairment on body and social function. The pain syndromes are not uncommon in breast cancer patients. It can affect social, psychological, physical and behavioral aspects of a patient. Surgery, radiation, chemotherapy and psychological factors can all contribute to the development of pain syndromes. Axillary dissection is a strong predictor for pain development. Pain medications, ganglion blocks are typically given to the patient for management. Integrative medicine such as acupuncture and psychological management methods are promising modalities in the management arsenal. In this study, we summarized the up-to-date literature to elucidate the etiology, risk factors and management strategies for PMPS.
C1 [Chen, Victor E.; Greenberger, Benjamin A.; Gajjar, Shefali; Shi, Wenyin; Yan, Weisi] Thomas Jefferson Univ, Dept Radiat Oncol, Sidney Kimmel Med Coll, 501 South 54th St, Philadelphia, PA 19143 USA.
   [Chen, Victor E.; Greenberger, Benjamin A.; Gajjar, Shefali; Shi, Wenyin; Yan, Weisi] Thomas Jefferson Univ, Canc Ctr, Philadelphia, PA 19143 USA.
   [Shi, Zheng] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiat Oncol, San Antonio, TX 78229 USA.
   [Mourad, Waleed F.] Univ Kentucky, Dept Radiat Oncol, Lexington, KY USA.
C3 Thomas Jefferson University; Thomas Jefferson University; University of
   Texas System; University of Texas at San Antonio; University of Kentucky
RP Yan, WS (corresponding author), Thomas Jefferson Univ, Dept Radiat Oncol, Sidney Kimmel Med Coll, 501 South 54th St, Philadelphia, PA 19143 USA.
EM Weisi.Yan@jefferson.edu
RI ; Shi, Wenyin/I-1321-2019
OI Chen, Victor/0000-0003-3190-5171; 
FU National Cancer Institute [UG1CA233341] Funding Source: NIH RePORTER;
   NCI NIH HHS [UG1 CA233341] Funding Source: Medline
CR Abbas DN, 2011, CLIN J PAIN, V27, P207, DOI 10.1097/AJP.0b013e3181fb1ef1
   Amr YM, 2010, CLIN J PAIN, V26, P381, DOI 10.1097/AJP.0b013e3181cb406e
   Andersen KG, 2011, J PAIN, V12, P725, DOI 10.1016/j.jpain.2010.12.005
   Bandos H, 2018, JNCI-J NATL CANCER I, V110, DOI 10.1093/jnci/djx162
   Baron RH, 2007, ANN SURG ONCOL, V14, P1653, DOI 10.1245/s10434-006-9334-z
   Belfer I, 2013, J PAIN, V14, P1185, DOI 10.1016/j.jpain.2013.05.002
   Blanchard DK, 2003, ARCH SURG-CHICAGO, V138, P482, DOI 10.1001/archsurg.138.5.482
   Bredal IS, 2014, J PAIN SYMPTOM MANAG, V48, P852, DOI 10.1016/j.jpainsymman.2013.12.239
   Bruehl S, 2004, NEUROSCI BIOBEHAV R, V28, P395, DOI 10.1016/j.neubiorev.2004.06.004
   Burstein HJ, 2010, J CLIN ONCOL, V28, P3784, DOI 10.1200/JOP.000082
   Carpenter JS, 1999, CANCER PRACT, V7, P66, DOI 10.1046/j.1523-5394.1999.07208.x
   Cepeda MS, 2008, J PAIN SYMPTOM MANAG, V35, P623, DOI 10.1016/j.jpainsymman.2007.08.011
   De Oliveira GS, 2014, BREAST J, V20, P9, DOI 10.1111/tbj.12207
   Din OS, 2010, BREAST CANCER RES TR, V120, P525, DOI 10.1007/s10549-010-0757-7
   Donker M, 2014, LANCET ONCOL, V15, P1303, DOI 10.1016/S1470-2045(14)70460-7
   Ducic I, 2006, J AM COLL SURGEONS, V203, P304, DOI 10.1016/j.jamcollsurg.2006.05.018
   Eckhoff L, 2015, EUR J CANCER, V51, P292, DOI 10.1016/j.ejca.2014.11.024
   Eija K, 1996, PAIN, V64, P293, DOI 10.1016/0304-3959(95)00138-7
   Fassoulaki A, 2002, ANESTH ANALG, V95, P985, DOI 10.1097/00000539-200210000-00036
   Fenlon D, 2014, BMC CANCER, V14, DOI 10.1186/1471-2407-14-467
   Friberg S, 2009, ACTA ONCOL, V48, P822, DOI 10.1080/02841860902824917
   Galecki J, 2006, ACTA ONCOL, V45, P280, DOI 10.1080/02841860500371907
   Gilbo P, 2018, ADV RADIAT ONCOL, V3, P265, DOI 10.1016/j.adro.2018.04.001
   Giuliano AE, 2011, JAMA-J AM MED ASSOC, V305, P569, DOI 10.1001/jama.2011.90
   Grover VK, 2009, J POSTGRAD MED, V55, P257, DOI 10.4103/0022-3859.58928
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hille-Betz U, 2016, STRAHLENTHER ONKOL, V192, P8, DOI 10.1007/s00066-015-0899-y
   Hopwood P, 2010, LANCET ONCOL, V11, P231, DOI 10.1016/S1470-2045(09)70382-1
   Hoseinzade H., 2008, Shiraz E Medical Journal, V9, P88
   Jagsi R, 2015, JAMA ONCOL, V1, P918, DOI 10.1001/jamaoncol.2015.2590
   Jeong YJ, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/5367014
   Juhl AA, 2016, J BREAST CANCER, V19, P447, DOI 10.4048/jbc.2016.19.4.447
   Jung BF, 2003, PAIN, V104, P1, DOI 10.1016/S0304-3959(03)00241-0
   Kadmon I, 2017, ASIA-PAC J ONCOL NUR, V4, P89, DOI 10.4103/apjon.apjon_16_17
   KIRVELA O, 1992, REGION ANESTH, V17, P348, DOI 10.1136/rapm-00115550-199217060-00007
   Lancaster RB, 2016, CURR SURG REP, V4, DOI 10.1007/s40137-016-0133-6
   Lötsch J, 2018, BREAST CANCER RES TR, V171, P399, DOI 10.1007/s10549-018-4841-8
   Lyman GH, 2014, J CLIN ONCOL, V32, P1365, DOI 10.1200/JCO.2013.54.1177
   McCann B, 2012, J PAIN, V13, P425, DOI 10.1016/j.jpain.2011.02.358
   Mejdahl MK, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f1865
   Meretoja TJ, 2014, JAMA-J AM MED ASSOC, V311, P90, DOI 10.1001/jama.2013.278795
   Miaskowski C, 2014, EUR J ONCOL NURS, V18, P242, DOI 10.1016/j.ejon.2013.12.002
   Mols F, 2014, SUPPORT CARE CANCER, V22, P2261, DOI 10.1007/s00520-014-2255-7
   Nahm Nicole, 2018, Asia Pac J Clin Oncol, V14, P374, DOI 10.1111/ajco.12845
   Nguyen JT, 2012, J PLAST RECONSTR AES, V65, P1199, DOI 10.1016/j.bjps.2012.04.003
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Fabro EAN, 2012, BREAST, V21, P321, DOI 10.1016/j.breast.2012.01.019
   Patarica-Huber E, 2011, J BUON, V16, P40
   Peintinger F, 2003, BRIT J CANCER, V89, P648, DOI 10.1038/sj.bjc.6601150
   Peretti-Watel P, 2012, PAIN RES TREAT, V2012, DOI 10.1155/2012/153060
   Rietman JS, 2003, EUR J SURG ONCOL, V29, P229, DOI 10.1053/ejso.2002.1403
   Romestaing P, 1997, J CLIN ONCOL, V15, P963, DOI 10.1200/JCO.1997.15.3.963
   Rosso R, 2000, ARCH PATHOL LAB MED, V124, P709
   Ryan JL, 2012, J INVEST DERMATOL, V132, P985, DOI 10.1038/jid.2011.411
   Schijven MP, 2003, EUR J SURG ONCOL, V29, P341, DOI 10.1053/ejso.2002.1385
   Shaitelman SF, 2015, JAMA ONCOL, V1, P931, DOI 10.1001/jamaoncol.2015.2666
   Shannon MT, 2011, J GEN INTERN MED, V26, P1217, DOI 10.1007/s11606-011-1702-0
   Smith HS, 2012, ANN PALLIAT MED, V1, P182, DOI 10.3978/j.issn.2224-5820.2012.10.13
   Steegers MA, 2008, J PAIN, V9, P813, DOI 10.1016/j.jpain.2008.04.001
   Stubblefield MD, 2006, ARCH PHYS MED REHAB, V87, pS96, DOI 10.1016/j.apmr.2005.12.017
   Swenson KK, 2002, ANN SURG ONCOL, V9, P745, DOI 10.1245/ASO.2002.02.007
   TASMUTH T, 1995, ANN ONCOL, V6, P453, DOI 10.1093/oxfordjournals.annonc.a059215
   Tasmuth T, 2002, EUR J PAIN-LONDON, V6, P17, DOI 10.1053/eujp.2001.0266
   Uchida K, 2009, PAIN PHYSICIAN, V12, pE277
   Vrieling C, 2017, JAMA ONCOL, V3, P42, DOI 10.1001/jamaoncol.2016.3031
   Wang K, 2018, BREAST, V42, P113, DOI 10.1016/j.breast.2018.08.105
   WATSON CPN, 1992, PAIN, V51, P375, DOI 10.1016/0304-3959(92)90223-X
   Wijayasinghe N, 2014, REGION ANESTH PAIN M, V39, P272, DOI 10.1097/AAP.0000000000000101
   Winters L, 2010, CLIN J ONCOL NURS, V14, P379, DOI 10.1188/10.CJON.379-382
   Winters-Stone KM, 2012, CANCER-AM CANCER SOC, V118, P2288, DOI 10.1002/cncr.27465
   Wong L, 2001, ANN PLAS SURG, V46, P481, DOI 10.1097/00000637-200105000-00004
NR 71
TC 11
Z9 14
U1 0
U2 13
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2218-676X
EI 2219-6803
J9 TRANSL CANCER RES
JI Transl. Cancer Res.
PD JAN
PY 2020
VL 9
SU 1
BP S77
EP S85
DI 10.21037/tcr.2019.06.46
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA KC8AO
UT WOS:000507394100010
PM 33828953
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Mazzei, LG
   Bergamaschi, CD
   Silva, MT
   Barberato, S
   Fulone, I
   Moura, MD
   Guimaraes, C
   Lopes, LC
AF Mazzei, Lauren Giustti
   Bergamaschi, Cristiane de Cassia
   Silva, Marcus Tolentino
   Barberato Filho, Silvio
   Fulone, Izabela
   Moura, Mariana Del Grossi
   Guimaraes, Caio
   Lopes, Luciane Cruz
TI Use of IMMPACT domains in clinical trials of acupuncture for chronic
   pain: A methodological survey
SO PLOS ONE
LA English
DT Article
ID LOW-BACK-PAIN; TENSION-TYPE HEADACHE; CORE OUTCOME DOMAINS; TRADITIONAL
   ACUPUNCTURE; KNEE OSTEOARTHRITIS; PHYSICAL FUNCTION; RANDOMIZED-TRIAL;
   NECK PAIN; MULTICENTER; MANAGEMENT
AB Acupuncture is one of the therapeutic resources used for the management of chronic pain. Variability in outcome measurements in randomized clinical trials of non-oncologic chronic pain (RCT-NOCP) generates inconsistencies in determining effects of treatments. The objective of this survey was to assess the adherence to the recommendations made by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) in the measurement of RCT-NOCP of acupuncture. This methodological research made a systematic search for eligible studies from different sources of information. Eligible studies included those with number of patients.100, who randomized and allocated patients with chronic non-oncologic pain to be treated with acupuncture or with "sham" acupuncture, or non-acupuncture. This research included the recommendations for IMMPACT in the measurement of RCT-NOCP: presence of outcomes pain, physical function, emotional state and improvement perception of patient, the source of the outcome information pain and the tools used to measure such domains. From a total of 1,386 studies, 24 were included in this survey. Eleven studies presented low risk of bias. Pain outcome was measured in 23 studies, physical function in 22 studies, emotional state in 14 studies and improvement perception of patient in one study. As for the pain outcome, the patient was the information source in 50% of the studies. The measurement tools recommended for IMMPACT were included in eight studies (35%) that evaluated pain, one study that evaluated the emotional state (7%), and one study that evaluated the improvement perception and satisfaction of patient. It was observed that studies which did not adhere to the recommendations had more favorable results for acupuncture in the outcome pain. This study concludes that randomized clinical trials that used acupuncture to manage chronic pain failed to adhere to IMMPACT recommendations. Clinical societies and IMMPACT do not share the same recommendations. This fact reflects in the diversity of outcomes and instruments adopted in the studies, making it difficult to compare the results.
C1 [Mazzei, Lauren Giustti; Bergamaschi, Cristiane de Cassia; Silva, Marcus Tolentino; Barberato Filho, Silvio; Fulone, Izabela; Moura, Mariana Del Grossi; Guimaraes, Caio; Lopes, Luciane Cruz] Univ Sorocaba, Pharmaceut Sci Grad Program, Sorocaba, SP, Brazil.
C3 Universidade de Sorocaba
RP Lopes, LC (corresponding author), Univ Sorocaba, Pharmaceut Sci Grad Program, Sorocaba, SP, Brazil.
EM luciane.lopes@prof.uniso.br
RI Silva, Marcus Tolentino/J-1791-2014; Guimaraes, Caio/AAX-5966-2020;
   Barberato-Filho, Silvio/J-3956-2015; Lopes, Luciane/H-3159-2019;
   Bergamaschi, Cristiane de Cássia/F-9911-2014
OI Silva, Marcus Tolentino/0000-0002-7186-9075; Fulone,
   Izabela/0000-0002-3211-6951; Barberato-Filho,
   Silvio/0000-0001-5179-3125; Lopes, Luciane/0000-0002-3684-3275;
   Bergamaschi, Cristiane de Cássia/0000-0002-6608-1806; Mazzei,
   Lauren/0000-0001-8611-5594
CR Abdulla A, 2013, AGE AGEING, V42, pI1, DOI 10.1093/ageing/afs200
   Akl EA, 2012, J CLIN EPIDEMIOL, V65, P262, DOI 10.1016/j.jclinepi.2011.04.015
   Berman BM, 2004, ANN INTERN MED, V141, P901, DOI 10.7326/0003-4819-141-12-200412210-00006
   Bes A, 2013, CEPHALALGIA, V33, P629, DOI 10.1177/0333102413485658
   Blanpied Peter R, 2017, J Orthop Sports Phys Ther, V47, pA1, DOI [10.2519/jospt.2017.0302, 10.2519/jospt.2017.0302]
   Borenstein M, 2010, RES SYNTH METHODS, V1, P97, DOI 10.1002/jrsm.12
   Brinkhaus B, 2006, ARCH INTERN MED, V166, P450
   Busse J, 2013, MODIFICATION COCHRAN
   Chen LX, 2013, JCR-J CLIN RHEUMATOL, V19, P308, DOI 10.1097/RHU.0b013e3182a21848
   Cho YJ, 2013, SPINE, V38, P549, DOI 10.1097/BRS.0b013e318275e601
   Collins NJ, 2011, ARTHRIT CARE RES, V63, pS208, DOI 10.1002/acr.20632
   CPSO, 2000, EV BAS REC MED MAN C
   Diener HC, 2006, LANCET NEUROL, V5, P310, DOI 10.1016/S1474-4422(06)70382-9
   Dworkin RH, 2008, J PAIN, V9, P105, DOI 10.1016/j.jpain.2007.09.005
   Dworkin RH, 2010, PAIN, V149, P177, DOI 10.1016/j.pain.2010.02.018
   Endres Heinz G, 2007, J Headache Pain, V8, P306, DOI 10.1007/s10194-007-0416-5
   Facco E, 2008, HEADACHE, V48, P398, DOI 10.1111/j.1526-4610.2007.00916.x
   Fairbanks CA, 2015, EUR J PHARMACOL, V759, P169, DOI 10.1016/j.ejphar.2015.03.049
   Foster NE, 2007, BMJ-BRIT MED J, V335, P436, DOI 10.1136/bmj.39280.509803.BE
   Guerriere DN, 2010, CAN J ANAESTH, V57, P549, DOI 10.1007/s12630-010-9306-4
   Haake M, 2007, ARCH INTERN MED, V167, P1892, DOI 10.1001/archinte.167.17.1892
   Higgins JP, 2011, COCHRANE HDB SYSTEMA
   Hinman RS, 2014, JAMA-J AM MED ASSOC, V312, P1313, DOI 10.1001/jama.2014.12660
   Hooten WM, 2011, NATL GUIDELINE CLEAR, P112
   IASP, 1994, CLASS CHRON PAIN INT
   Irnich D, 2001, BMJ-BRIT MED J, V322, P1574, DOI 10.1136/bmj.322.7302.1574
   Jena S, 2008, CEPHALALGIA, V28, P969, DOI 10.1111/j.1468-2982.2008.01640.x
   KOPF AP, 2010, GUIA TRAT DOR CONT P
   Liang ZH, 2011, COMPLEMENT THER MED, V19, pS26, DOI 10.1016/j.ctim.2010.11.005
   Linde K, 2005, JAMA-J AM MED ASSOC, V293, P2118, DOI 10.1001/jama.293.17.2118
   Mazzei LG, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-014904
   Melchart D, 2005, BMJ-BRIT MED J, V331, P376, DOI 10.1136/bmj.38512.405440.8F
   Molsberger AF, 2002, PAIN, V99, P579, DOI 10.1016/S0304-3959(02)00269-5
   Molsberger AF, 2011, DTSCH Z AKUPUNKT, V54, P35, DOI 10.1016/j.dza.2011.01.008
   Mulla SM, 2015, PAIN, V156, P1615, DOI 10.1097/j.pain.0000000000000241
   OMS, 2013, ESTR OMS MED TRAD 20
   Qaseem Amir, 2017, Ann Intern Med, V166, P514, DOI 10.7326/M16-2367
   Rasu RS, 2014, J MANAG CARE SPEC PH, V20, P921, DOI 10.18553/jmcp.2014.20.9.921
   RNAO, 2013, ASS MAN PAIN REG NUR
   Rosenquist RW, 2010, ANESTHESIOLOGY, V112, P810, DOI 10.1097/ALN.0b013e3181c43103
   Scharf HP, 2006, ANN INTERN MED, V145, P12, DOI 10.7326/0003-4819-145-1-200607040-00005
   SIGN, 2013, MAN CHRON PAIN NAT C
   Taylor AM, 2016, PAIN, V157, P1836, DOI 10.1097/j.pain.0000000000000577
   Thomas KJ, 2006, BMJ-BRIT MED J, V333, P623, DOI 10.1136/bmj.38878.907361.7C
   Turk DC, 2003, PAIN, V106, P337, DOI 10.1016/j.pain.2003.08.001
   Turk DC, 2008, PAIN, V139, P485, DOI 10.1016/j.pain.2008.06.025
   Turk DC, 2006, PAIN, V125, P208, DOI 10.1016/j.pain.2006.09.028
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   White P, 2004, ANN INTERN MED, V141, P911, DOI 10.7326/0003-4819-141-12-200412210-00007
   Witt C, 2005, LANCET, V366, P136, DOI 10.1016/S0140-6736(05)66871-7
   Witt CM, 2006, PAIN, V125, P98, DOI 10.1016/j.pain.2006.05.013
   Witt CM, 2006, ARTHRITIS RHEUM-US, V54, P3485, DOI 10.1002/art.22154
   Witt CM, 2006, AM J EPIDEMIOL, V164, P487, DOI 10.1093/aje/kwj224
   Yeh TS, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-144
   Yin C, 2017, CURR OPIN ANESTHESIO, V30, P583, DOI 10.1097/ACO.0000000000000501
NR 55
TC 5
Z9 6
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 16
PY 2020
VL 15
IS 4
AR e0231444
DI 10.1371/journal.pone.0231444
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LR9JM
UT WOS:000536011400047
PM 32298300
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wong, CHL
   Wong, W
   Lin, WL
   Au, DKY
   Wu, JCY
   Leung, TH
   Wu, IXY
   Chung, VCH
AF Wong, Charlene H. L.
   Wong, Wendy
   Lin, Wai Ling
   Au, David K. Y.
   Wu, Justin C. Y.
   Leung, Ting Hung
   Wu, Irene X. Y.
   Chung, Vincent C. H.
TI Prioritizing Chinese medicine clinical research questions in cancer
   palliative care from patient and caregiver perspectives
SO HEALTH EXPECTATIONS
LA English
DT Article
DE palliative care; patient participation; research priorities; stakeholder
   participation; traditional chinese medicine
ID QUALITY-OF-LIFE; SYMPTOM MANAGEMENT; HERBAL MEDICINE; PAIN; ACUPUNCTURE;
   ONCOLOGY; FAMILY; PAPER
AB Background Chinese medicine (CM) modalities, including acupuncture and Chinese herbal medicine (CHM), are popular palliative interventions among patients with cancer, but further clinical research is required to assess their effectiveness and safety.
   Objective To prioritize top ten important CM clinical research questions from patients with cancer, cancer survivors and caregivers' perspectives via a face-to-face prioritization workshop in Hong Kong.
   Methods A list of 25 CM clinical research questions for cancer palliative care, which were identified from existing systematic reviews (SRs) and overview of SRs, was presented to 17 participants (patients with cancer [n = 5], cancer survivors [n = 6] and caregivers [n = 6]). The participants were then invited to establish consensus on prioritizing top ten research questions.
   Results Among the top ten priorities, five (50%) focused on acupuncture and related therapies, while five (50%) were on CHM. The three most important research priorities were (i) manual acupuncture plus opioids for relieving pain; (ii) CHM for improving quality of life among patients receiving chemotherapy; and (iii) concurrent use of CHM plus loperamide for reducing stomatitis.
   Conclusion The top ten participant-endorsed CM clinical research priorities for cancer palliative care can guide local researchers on future direction. They can also inform local research funders on patient-centred allocation of limited funding. Under limited research funding, the most important co-prioritized research question from professional and patient perspectives may be addressed first.
   Patient or Public Contribution Patients with cancer, cancer survivors and caregivers participated in conduct of the study to prioritize CM clinical research questions.
C1 [Wong, Charlene H. L.; Wu, Justin C. Y.] Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.
   [Wong, Charlene H. L.; Leung, Ting Hung; Chung, Vincent C. H.] Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Shatin, Hong Kong, Peoples R China.
   [Wong, Wendy] Beijing Univ Chinese Med, Natl Inst TCM Constitut & Prevent Med, Beijing, Peoples R China.
   [Wong, Wendy] Yat Hei Hong Kong Co Ltd, Hong Kong, Peoples R China.
   [Lin, Wai Ling; Au, David K. Y.] Chinese Univ Hong Kong, Hong Kong Inst Integrat Med, Shatin, Hong Kong, Peoples R China.
   [Leung, Ting Hung; Chung, Vincent C. H.] Chinese Univ Hong Kong, Sch Chinese Med, Shatin, Hong Kong, Peoples R China.
   [Wu, Irene X. Y.] Cent South Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Beijing University of Chinese Medicine; Chinese University of Hong Kong;
   Chinese University of Hong Kong; Central South University
RP Wong, W (corresponding author), 15-F Eubank Plaza,9 Chiu Lung St, Hong Kong, Peoples R China.
EM charlene.wong@link.cuhk.edu.hk; wendywong110@gmail.com;
   wllin@cuhk.edu.hk; davidau@cuhk.edu.hk; justinwu@cuhk.edu.hk;
   leungthcmph@cuhk.edu.hk; irenexywu@csu.edu.cn; vchung@cuhk.edu.hk
RI ; Wong, Wendy/H-3939-2016; Chung, Vincent/K-2447-2013
OI Wu, Irene XY/0000-0003-3772-2376; Wong, Wendy/0000-0001-8731-0498; 
FU Food and Health Bureau, Hong Kong SAR Government [14153141]
FX The study was supported by the Health and Medical Research Fund, Food
   and Health Bureau (reference number: 14153141, 2017), Hong Kong SAR
   Government. The Food and Health Bureau had no involvement in the study
   design, data collection and analysis, manuscript preparation or decision
   to submit this article for publication
CR Adam R, 2015, BRIT J GEN PRACT, V65, pE754, DOI 10.3399/bjgp15X687397
   Aldiss S, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-028119
   [Anonymous], 2016, NCCN Clinical Practice Guidelines in Oncology
   Bhatnagar S, 2015, INDIAN J PALLIAT CAR, V21, P95, DOI [10.4103/0973-1075.150201, 10.4103/0973-1075.173939]
   Cao HJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031793
   Chalmers I, 2014, LANCET, V383, P156, DOI 10.1016/S0140-6736(13)62229-1
   Chalmers I, 2013, J ROY SOC MED, V106, P482, DOI 10.1177/0141076813493063
   Chamberlain C, 2019, HEALTH POLICY, V123, P706, DOI 10.1016/j.healthpol.2019.05.022
   Chung VCH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002793
   Chung VCH, 2015, SCI REP-UK, V5, DOI 10.1038/srep18111
   del Río MI, 2012, PSYCHO-ONCOLOGY, V21, P913, DOI 10.1002/pon.2099
   Duan Naihua, 2013, Shanghai Arch Psychiatry, V25, P325, DOI 10.3969/j.issn.1002-0829.2013.05.011
   Fan AY, 2017, J INTEGR MED-JIM, V15, P411, DOI 10.1016/S2095-4964(17)60378-9
   Francis JJ, 2010, PSYCHOL HEALTH, V25, P1229, DOI 10.1080/08870440903194015
   Guise JM, 2013, J CLIN EPIDEMIOL, V66, P666, DOI 10.1016/j.jclinepi.2012.12.010
   Henson LA, 2020, J CLIN ONCOL, V38, P905, DOI 10.1200/JCO.19.00470
   Higginson IJ, 2014, PALLIATIVE MED, V28, P101, DOI 10.1177/0269216313488989
   Hollis C, 2018, LANCET PSYCHIAT, V5, P845, DOI 10.1016/S2215-0366(18)30296-7
   International Agency for Research on Cancer. World Health Organization, 2020, ESTIMATED NUMBER DEA
   Islam KM, 2014, J CANCER EDUC, V29, P796, DOI 10.1007/s13187-014-0657-3
   Jones AP, 2013, BMC MED RES METHODOL, V13, DOI 10.1186/1471-2288-13-50
   Jordan K, 2018, ANN ONCOL, V29, P36, DOI 10.1093/annonc/mdx757
   Lai JN, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/697893
   Lam Yuen-chi, 2009, Chin Med, V4, P25, DOI 10.1186/1749-8546-4-25
   Latte-Naor S, 2019, J ONCOL PRACT, V15, P7, DOI 10.1200/JOP.18.00554
   Lau CHY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002901
   Li B, 2019, J PALLIAT MED, V22, P1252, DOI 10.1089/jpm.2018.0622
   Liu J, 2015, THORAC CANCER, V6, P561, DOI 10.1111/1759-7714.12270
   Liu Q, 2018, PAIN MANAG NURS, V19, P506, DOI 10.1016/j.pmn.2017.11.006
   Meeker MA, 2011, J FAM NURS, V17, P29, DOI 10.1177/1074840710396091
   Reid J, 2009, INT J NURS STUD, V46, P606, DOI 10.1016/j.ijnurstu.2008.10.012
   Robinson KA, 2011, J CLIN EPIDEMIOL, V64, P1325, DOI 10.1016/j.jclinepi.2011.06.009
   Sakashita A, 2018, J PAIN SYMPTOM MANAG, V55, P379, DOI 10.1016/j.jpainsymman.2017.09.012
   Shippee ND, 2015, HEALTH EXPECT, V18, P1151, DOI 10.1111/hex.12090
   Solheim TS, 2014, ACTA ONCOL, V53, P539, DOI 10.3109/0284186X.2013.823239
   Strömgren AS, 2006, J PAIN SYMPTOM MANAG, V31, P199, DOI 10.1016/j.jpainsymman.2005.07.007
   UpToDate, 2020, CANC PAIN MANAGEMENT
   Wang ZX, 2019, COMPLEMENT THER MED, V43, P165, DOI 10.1016/j.ctim.2019.01.027
   Weeks LC, 2013, CURR ONCOL, V20, pE289, DOI 10.3747/co.20.1378
   WHO, 2012, WORLD MALARIA REPORT 2012, P1
   Wong CHL, 2019, J PAIN SYMPTOM MANAG, V58, P1002, DOI 10.1016/j.jpainsymman.2019.08.002
   Wu XL, 2015, SCI REP-UK, V5, DOI [10.1038/srep11728, 10.1038/srep16776]
   Wu XY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002410
   Zeng YC, 2019, CURR ONCOL REP, V21, DOI 10.1007/s11912-019-0786-2
NR 44
TC 7
Z9 9
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1369-6513
EI 1369-7625
J9 HEALTH EXPECT
JI Health Expect.
PD AUG
PY 2021
VL 24
IS 4
BP 1487
EP 1497
DI 10.1111/hex.13289
EA JUN 2021
PG 11
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA UB5UX
UT WOS:000659241600001
PM 34107142
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, HJ
   Schlaeger, JM
   Patil, CL
   Danciu, OC
   Xia, YL
   Sun, J
   Doorenbos, AZ
AF Li, Hongjin
   Schlaeger, Judith M.
   Patil, Crystal L.
   Danciu, Oana C.
   Xia, Yinglin
   Sun, Jun
   Doorenbos, Ardith Z.
TI Feasibility of Acupuncture and Exploration of Metabolomic Alterations
   for Psychoneurological Symptoms Among Breast Cancer Survivors
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE acupuncture; psychoneurological symptoms; metabolites; breast cancer
ID BIOELECTRICAL-IMPEDANCE ANALYSIS; VECTOR ANALYSIS BIVA; BRAIN
   NATRIURETIC PEPTIDE; ACUTE HEART-FAILURE; BODY-COMPOSITION; PHASE-ANGLE;
   BIOIMPEDANCE ANALYSIS; SCIENTIFIC STATEMENT; PROGNOSTIC VALUE; DIAGNOSIS
AB Objective Approximately 24-68% of breast cancer survivors report co-occurring psychoneurological symptoms of pain, fatigue, sleep disturbance, depression, and anxiety during and after cancer treatment. This study aimed to assess the feasibility and acceptability of acupuncture for the treatment of multiple psychoneurological symptoms among breast cancer survivors and explore metabolomic changes before and after acupuncture. Methods We conducted a single-arm, prospective pilot study of breast cancer survivors with at least two moderate to severe psychoneurological symptoms (>3 on a 0-10 scale). Acupuncture was administered twice weekly for 5 weeks, for 30 minutes per session. Along with Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires, a fasting serum comprehensive hydrophilic metabolites panel was analyzed at baseline and after acupuncture. Results Eight participants (mean age 52.5 +/- 10.9 years; 62.5% Black) were enrolled. Feasibility was supported, with 67% recruitment, 87.5% retention, and 98% acceptability. Post intervention, PROMIS T-scores were reduced for all psychoneurological symptoms. Significant differences in serum metabolites before and after acupuncture were F-1,6/2,6-DP, glutathione disulfide, phosphorylcholine, 6-methylnicotinamide, glutathione, and putrescine (variable importance of projection values larger than 1.5 and p values <0.05). Pathway analysis indicated that glutathione metabolism (p = 0.002, q = 0.071), and arginine and proline metabolisms (p = 0.009, q = 0.166) were potentially involved in mechanisms of acupuncture. Conclusions Acupuncture to reduce multiple psychoneurological symptoms among breast cancer survivors was feasible and acceptable. Study findings also shed light on the metabolic pathways involved in the acupuncture response and will be tested in future studies.
C1 [Li, Hongjin; Schlaeger, Judith M.; Patil, Crystal L.] Univ Illinois, Coll Nursing, Dept Human Dev Nursing Sci, Chicago, IL 60612 USA.
   [Li, Hongjin; Danciu, Oana C.; Sun, Jun; Doorenbos, Ardith Z.] Univ Illinois, Canc Ctr, Chicago, IL 60612 USA.
   [Danciu, Oana C.; Xia, Yinglin; Sun, Jun] Univ Illinois, Coll Med, Chicago, IL 60612 USA.
   [Doorenbos, Ardith Z.] Univ Illinois, Coll Nursing, Dept Biobehav Nursing Sci, Chicago, IL 60612 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital
RP Li, HJ (corresponding author), Univ Illinois, 845 S Damen Ave,MC 802, Chicago, IL 60612 USA.
EM hongjin@uic.edu
RI ; Patil, Crystal/H-7509-2016; schlaeger, judith/N-4482-2017
OI Sun, Jun/0000-0001-7465-3133; Patil, Crystal/0000-0003-4536-4599; Li,
   Hongjin/0000-0002-5466-1192; 
FU National Center for Complementary and Integrative Health of the National
   Institutes of Health [K24AT011995-01]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article. Research
   reported in this study was supported by the National Center for
   Complementary and Integrative Health of the National Institutes of
   Health under Award Number K24AT011995-01.
CR Agus A, 2018, CELL HOST MICROBE, V23, P716, DOI 10.1016/j.chom.2018.05.003
   Al-Bashaireh AM, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.19953
   Amtmann D, 2010, PAIN, V150, P173, DOI 10.1016/j.pain.2010.04.025
   Bahrami Taghanaki H.R., 2021, J. Nutr. Fasting Health, V9, P196, DOI DOI 10.22038/JNFH.2021.54314.1310
   Beger RD, 2016, METABOLOMICS, V12, DOI 10.1007/s11306-016-1094-6
   Bellg AJ, 2004, HEALTH PSYCHOL, V23, P443, DOI 10.1037/0278-6133.23.5.443
   BENJAMINI Y, 1995, J ROY STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Bjerkeset E, 2020, BREAST CANCER RES TR, V180, P63, DOI 10.1007/s10549-020-05522-8
   Borrelli B, 2005, J CONSULT CLIN PSYCH, V73, P852, DOI 10.1037/0022-006X.73.5.852
   Brauer JA, 2010, J ALTERN COMPLEM MED, V16, P183, DOI 10.1089/acm.2009.0354
   Cella D, 2010, J CLIN EPIDEMIOL, V63, P1179, DOI 10.1016/j.jclinepi.2010.04.011
   Cessna JM, 2016, J PSYCHOSOM RES, V81, P9, DOI 10.1016/j.jpsychores.2015.12.002
   Chou YJ, 2021, BIOL RES NURS, V23, P42, DOI 10.1177/1099800420942586
   Doong SH, 2015, BIOL RES NURS, V17, P237, DOI 10.1177/1099800414550394
   Dorland HF, 2018, J CANCER SURVIV, V12, P371, DOI 10.1007/s11764-018-0676-x
   Eaton LH, 2011, NURS RES, V60, P430, DOI 10.1097/NNR.0b013e31823386aa
   Garland SN, 2017, MENOPAUSE, V24, P517, DOI 10.1097/GME.0000000000000779
   Giovanni M., 1989, The Foundations of Chinese Medicine: A Comprehensive Text for Acupuncturists and Herbalists, P219
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Kim HJ, 2012, CANCER NURS, V35, pE1, DOI 10.1097/NCC.0b013e318233a811
   Kornilov V., 2022, EUR J PSYCHIAT, V36, P288, DOI [10.17116/jnevro2022122081136, DOI 10.17116/JNEVRO2022122081136]
   Kwekkeboom KL, 2020, ONCOL NURS FORUM, V47, P498, DOI 10.1188/20.ONF.498-511
   Kwekkeboom KL, 2018, J PAIN SYMPTOM MANAG, V55, P1286, DOI 10.1016/j.jpainsymman.2018.01.008
   Langford DJ, 2016, SUPPORT CARE CANCER, V24, P605, DOI 10.1007/s00520-015-2819-1
   Li HJ, 2021, J ALTERN COMPLEM MED, V27, P1084, DOI 10.1089/acm.2021.0133
   Li W, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000022752
   Lozano F., 2014, Acupuncture for Pain Management, P13, DOI [10.1007/978-1-4614-5275-12, DOI 10.1007/978-1-4614-5275-12]
   MacPherson H, 2010, J ALTERN COMPLEM MED, V16, pST1, DOI 10.1089/acm.2010.1610
   Mannes ZL, 2022, J GEN INTERN MED, V37, P3937, DOI 10.1007/s11606-021-07370-8
   Mardinoglu A, 2015, MOL SYST BIOL, V11, DOI 10.15252/msb.20156487
   Morris G, 2014, MOL NEUROBIOL, V50, P1059, DOI 10.1007/s12035-014-8705-x
   Paice JA, 2016, J CLIN ONCOL, V34, P3325, DOI 10.1200/JCO.2016.68.5206
   Pilkonis PA, 2011, ASSESSMENT, V18, P263, DOI 10.1177/1073191111411667
   Quach CW, 2016, QUAL LIFE RES, V25, P2811, DOI 10.1007/s11136-016-1325-3
   Schumacher r., 2021, AM SOC BREAST SURGEO
   Smith C, 2013, ACUPUNCT MED, V31, P9, DOI 10.1136/acupmed-2012-010228
   Starkweather A, 2017, SUPPORT CARE CANCER, V25, P167, DOI 10.1007/s00520-016-3400-2
   Su XT, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/7875396
   Weljie AM, 2011, J BIOMOL NMR, V49, P185, DOI 10.1007/s10858-011-9486-4
   Wilkie DJ, 2003, J PAIN SYMPTOM MANAG, V25, P213, DOI 10.1016/S0885-3924(02)00638-3
   Wilkie DJ, 2001, FAM COMMUNITY HEALTH, V24, P48, DOI 10.1097/00003727-200110000-00007
   Wu YY, 2017, EXP THER MED, V14, P107, DOI 10.3892/etm.2017.4479
   Xia Y., 2022, AM CHEM SOC, DOI [10.1021/acsinfocus.7e5035, DOI 10.1021/ACSINFOCUS.7E5035]
   Xiao Bin, 2014, Zhongguo Zhen Jiu, V34, P956
   Yu L, 2012, BEHAV SLEEP MED, V10, P6, DOI 10.1080/15402002.2012.636266
   Zhang AH, 2016, SCI REP-UK, V6, DOI 10.1038/srep19942
   Zhang CJ, 2023, HEALTH COMMUN, V38, P275, DOI 10.1080/10410236.2021.1950292
   Zhou W, 2014, J ACUPUNCT MERIDIAN, V7, P190
NR 48
TC 5
Z9 5
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD APR
PY 2023
VL 25
IS 2
BP 326
EP 335
DI 10.1177/10998004221136567
EA OCT 2022
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nursing
GA 9Y2EK
UT WOS:000875969600001
PM 36306737
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Mattia, C
   Luongo, L
   Innamorato, M
   Melis, L
   Sofia, M
   Zappi, L
   Puntillo, F
AF Mattia, Consalvo
   Luongo, Livio
   Innamorato, Massimo
   Melis, Luca
   Sofia, Michele
   Zappi, Lucia
   Puntillo, Filomena
TI An Italian Expert Consensus on the Use of Opioids for the Management of
   Chronic Non-Oncological Pain in Clinical Practice: Focus on
   Buprenorphine
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE pain; chronic; non-oncological; strong opioids; buprenorphine; Delphi
   survey
ID CHRONIC NONCANCER PAIN; TRANSDERMAL BUPRENORPHINE; ANALGESICS;
   MECHANISM; THERAPY
AB Purpose: The aim of the present work was to evaluate the knowledge and prescriptive habits of clinicians involved in the management of chronic non cancer pain (CNCP), with a special focus on the use of opioids. Methods: A Delphi method was used. A Board of specialists elaborated and discussed a series of statements, based on available literature and personal clinical expertise, about particularly controversial topics on pain pathophysiology and treatment. A Panel of experts in the field of pain management, selected by the Board, was invited to vote the proposed statements, indicating the level of agreement on a 5-point Likert scale (1: strongly disagree; 2: disagree; 3: partially agree; 4: agree; 5: strongly agree). The threshold for consensus was set at minimum 66.6% of the number of respondents with a level of agreement >= 4 (Agree or Strongly agree). Results: The Board included 5 pain therapists, 1 pharmacologist and 1 methodology expert and drew up a total of 36 statements (for a total of 40 requested answers)". A total of 100 clinicians were included in the Expert Panel. Respondents were 89 (89%). Consensus was achieved for 32 out of 40 answers. Most of the lack of consensus was recorded for statements regarding opioids use, and resulted from a low level of agreement (3 on the Likert scale), suggesting a neutral position deriving from a lack of knowledge rather than a strong contrary opinion. Conclusion: Most of the proposed items reached consensus, suggesting a generally homogeneous approach to CNCP management. However, the lack of consensus recorded for several items regarding opioid use confirms the need to fill important gaps in the knowledge of available agents. A clear explanation of the peculiar pharmacological properties of drugs associated with potential clinical advantages (such as buprenorphine) will help optimize pain treatment in both primary care and hospital settings and improving pain control in CNCP patients.
C1 [Mattia, Consalvo] Sapienza Univ Rome, Fac Pharm & Med, Dept Med & Surg Sci & Biotechnol, Rome, Italy.
   [Mattia, Consalvo] ICOT Polo Pontino, Anesthesia Intens Care & Pain Unit, Latina, Italy.
   [Luongo, Livio] Univ Campania L Vanvitelli, Dept Expt Med, Div Pharmacol, Naples, Italy.
   [Luongo, Livio] NEUROMED, Pozzilli, Italy.
   [Innamorato, Massimo] AUSL Romagna, SM Croci Hosp Ravenna, Pain Therapy Unit, Ravenna, Italy.
   [Melis, Luca] Poliste, Cagliari, Italy.
   [Sofia, Michele] ASST Rodhense, Dept Palliat Care & Pain Therapy, Garbagnate Milanese, Italy.
   [Zappi, Lucia] San Martino Polyclin Hosp, Emergency & Acceptance Dept, UOC Antalg Therapy, Genoa, Italy.
   [Puntillo, Filomena] Aldo Moro Univ Bari, Dept Interdisciplinary Med, I-70124 Bari, Italy.
   [Puntillo, Filomena] Policlin Hosp Bari, Anesthesia Intens Care & Pain Unit, I-70124 Bari, Italy.
C3 Sapienza University Rome; Universita della Campania Vanvitelli; IRCCS
   Neuromed; AUSL della Romagna
RP Mattia, C (corresponding author), Univ Sapienza, Dept Med & Surg Sci, Corso Repubbl 79, I-04100 Latina, Italy.
EM consalvo.mattia@uniroma1.it
RI Luongo, Livio/GXV-1993-2022; Melis, Luca/HII-9261-2022
OI Melis, Luca/0000-0002-1946-6578; MATTIA, Consalvo/0000-0003-1894-9575;
   Innamorato, Massimo Antonio/0000-0001-8127-2355; Puntillo,
   Filomena/0000-0001-7274-6467
FU Camilla Ciani, Poliste Srl; Sandoz SpA
FX Project management support was provided by Camilla Ciani, Poliste Srl.
   These supports were made possible thanks to an unrestricted grant of
   Sandoz SpA.
CR Aloisi Anna Maria, 2009, Psychoneuroendocrinology, V34 Suppl 1, pS162, DOI 10.1016/j.psyneuen.2009.05.013
   Anekar AA, 2020, STATPEARLS
   Bawor M, 2015, DRUG ALCOHOL DEPEN, V149, P1, DOI 10.1016/j.drugalcdep.2015.01.038
   Behzadi M, 2018, MED PRIN PRACT, V27, P401, DOI 10.1159/000492616
   Bindu S, 2020, BIOCHEM PHARMACOL, V180, DOI 10.1016/j.bcp.2020.114147
   Bliesener N, 2005, J CLIN ENDOCR METAB, V90, P203, DOI 10.1210/jc.2004-0929
   Bohn LM, 2000, NATURE, V408, P720, DOI 10.1038/35047086
   Caraceni A, 2012, LANCET ONCOL, V13, pE58, DOI 10.1016/S1470-2045(12)70040-2
   Chen L, 2013, J PAIN, V14, P384, DOI 10.1016/j.jpain.2012.12.012
   Coluzzi F, 2018, J ENDOCRINOL INVEST, V41, P1377, DOI 10.1007/s40618-018-0964-3
   Costa T, 2018, ACTA REUMATOL PORT, V43, P172
   Coull JAM, 2005, NATURE, V438, P1017, DOI 10.1038/nature04223
   Cuomo A, 2019, J PAIN RES, V12, P711, DOI 10.2147/JPR.S178910
   Davis MP, 2018, DRUGS, V78, P1211, DOI 10.1007/s40265-018-0953-z
   Davis MP, 2016, CURR ONCOL REP, V18, DOI 10.1007/s11912-016-0558-1
   Demartini L, 2019, NEUROMODULATION, V22, P327, DOI 10.1111/ner.12867
   Ding Z, 2009, BRIT J PHARMACOL, V157, P831, DOI 10.1111/j.1476-5381.2009.00209.x
   Dowell D, 2016, JAMA-J AM MED ASSOC, V315, P1624, DOI 10.1001/jama.2016.1464
   Fishman MA, 2018, CURR PAIN HEADACHE R, V22, DOI 10.1007/s11916-018-0732-2
   Fornasari D, 2020, Pharmadvances, V02, DOI [10.36118/pharmadvances.01.2020.08, DOI 10.36118/PHARMADVANCES.01.2020.08, 10.36118/pharmadvances.01.2020.08]
   Fu K, 2018, RHEUMATOLOGY, V57, P43, DOI 10.1093/rheumatology/kex419
   Glanz JM, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.2613
   Guillou-Landreat M, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18042097
   Harris SC, 2017, POSTGRAD MED, V129, P69, DOI 10.1080/00325481.2017.1270156
   Heijmans L, 2020, POSTGRAD MED, V132, P17, DOI 10.1080/00325481.2020.1769393
   Higgins C, 2018, BRIT J ANAESTH, V120, P1335, DOI 10.1016/j.bja.2018.03.009
   Hutchinson MR, 2011, PHARMACOL REV, V63, P772, DOI 10.1124/pr.110.004135
   Hylands-White N, 2017, RHEUMATOL INT, V37, P29, DOI 10.1007/s00296-016-3481-8
   Infantino R, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11060816
   Ingrasciotta Y, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0222836
   Isagulyan E, 2020, KOREAN J PAIN, V33, P99, DOI 10.3344/kjp.2020.33.2.99
   Jacobsen JHW, 2014, INT REV NEUROBIOL, V118, P129, DOI 10.1016/B978-0-12-801284-0.00006-3
   Johnson RE, 2005, J PAIN SYMPTOM MANAG, V29, P297, DOI 10.1016/j.jpainsymman.2004.07.005
   JONES J, 1995, BRIT MED J, V311, P376, DOI 10.1136/bmj.311.7001.376
   Lamprecht A, 2018, EUR J ENDOCRINOL, V179, P353, DOI 10.1530/EJE-18-0530
   Likar Rudolf, 2006, Ther Clin Risk Manag, V2, P115
   Lippe PM, 2010, PAIN MED, V11, P1447, DOI 10.1111/j.1526-4637.2010.00961.x
   Malfait AM, 2013, NAT REV RHEUMATOL, V9, P654, DOI 10.1038/nrrheum.2013.138
   Manchikanti L, 2017, PAIN PHYSICIAN, V20, pS3, DOI 10.36076/ppj.2017.s92
   Mills S, 2016, CURR PSYCHIAT REP, V18, DOI 10.1007/s11920-015-0659-9
   Mills SEE, 2019, BRIT J ANAESTH, V123, pE273, DOI 10.1016/j.bja.2019.03.023
   Özcan Ç, 2019, PAIN PRACT, V19, P821, DOI 10.1111/papr.12812
   Pacifico S, 2020, J MED CHEM, V63, P10782, DOI 10.1021/acs.jmedchem.9b02057
   Pedersen L, 2014, ACTA ANAESTH SCAND, V58, P390, DOI 10.1111/aas.12279
   Pedersen MF, 2020, NEUROPHARMACOLOGY, V166, DOI [10.1016/j.neuropharrn.2019.107718, 10.1016/j.neuropharm.2019.107718]
   Pergolizzi JV, 2019, J PAIN RES, V12, P3299, DOI 10.2147/JPR.S231948
   Pergolizzi JV, 2018, EXPERT REV NEUROTHER, V18, P359, DOI 10.1080/14737175.2018.1462701
   Pergolizzi Joseph V Jr, 2015, Acta Anaesthesiol Taiwan, V53, P71, DOI [10.1016/j.aat.2015.06.001, 10.1016/j.aat.2015.06.001]
   Simpson RW, 2016, DIABETES CARE, V39, P1493, DOI 10.2337/dc16-0123
   Staunton CA, 2013, CURR PAIN HEADACHE R, V17, DOI 10.1007/s11916-013-0378-z
   Stein M, 2020, ADDICTION, V115, P82, DOI 10.1111/add.14737
   Treede RD, 2019, PAIN, V160, P19, DOI 10.1097/j.pain.0000000000001384
   van Hecke O, 2013, BRIT J ANAESTH, V111, P13, DOI 10.1093/bja/aet123
   Varrassi G, 2020, J PAIN RES, V13, P979, DOI 10.2147/JPR.S243222
   Webster LR, 2020, ADV THER, V37, P4685, DOI 10.1007/s12325-020-01481-0
   Yang J, 2020, J PAIN RES, V13, P411, DOI 10.2147/JPR.S244173
   Zamarripa CA, 2018, DRUG ALCOHOL DEPEN, V192, P158, DOI 10.1016/j.drugalcdep.2018.08.002
NR 57
TC 3
Z9 3
U1 1
U2 10
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2021
VL 14
BP 3193
EP 3206
DI 10.2147/JPR.S314206
PG 14
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA WK5AQ
UT WOS:000709738500011
PM 34675646
OA Green Submitted, Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Fan, DH
   Ren, HB
AF Fan, Dihui
   Ren, Hongbin
TI Clinical value of warm acupuncture combined with Jiaji acupoint Tongbian
   scraping therapy in the treatment of myofascial pain syndrome of the
   lumbar and dorsal muscles with wind-cold-dampness obstruction syndrome
SO MEDICINE
LA English
DT Article
DE Jiaji acupoint Tongbian scraping therapy; myofascial pain syndrome; warm
   acupuncture; wind-cold-dampness obstruction syndrome
AB This study investigates the clinical value of warm acupuncture combined with Jiaji acupoint Tongbian scraping therapy in patients with myofascial pain syndrome (MPS) of the lumbar and dorsal muscles with wind-cold-dampness obstruction syndrome. A total of 112 patients with wind-cold-dampness obstruction-type MPS admitted to our hospital from January 2024 to October 2024 were enrolled. According to different treatment methods, they were assigned into the control group (n = 35, Jiaji acupoint Tongbian scraping therapy), observation group (n = 35, warm acupuncture), and combination group (n = 42, warm acupuncture combined with Jiaji acupoint Tongbian scraping therapy). The following indicators were compared before and after treatment: Traditional Chinese Medicine (TCM) syndrome scores, visual analog scale (VAS) scores, Oswestry Disability Index (ODI) scores, Modified Barthel Index (MBI) scores, serum inflammatory cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta), clinical efficacy, and incidence of adverse reactions. After treatment, serum inflammatory cytokine levels, TCM syndrome scores, VAS, and ODI scores were significantly lower in the combination group than in the control and observation groups, while the MBI score was significantly higher (F = 22.340, 11.200, 17.130, 40.120, 4.850, 20.960, 14.680; P < .05). The overall effective rate in the combination group (95.24%) was significantly higher than that in the control group (74.29%) and the observation group (77.14%) (chi(2) = 7.205, P < .05). The incidence of adverse reactions in the combination group (16.67%) showed no significant difference compared with the control group (11.43%) and the observation group (14.29%) (chi(2) = 0.428, P > .05). Warm acupuncture combined with Jiaji acupoint Tongbian scraping therapy can effectively improve clinical symptoms and functional impairment, reduce pain and inflammatory levels, and enhance activities of daily living, without significantly increasing adverse reactions. This combined approach demonstrates high clinical efficacy.
C1 [Fan, Dihui; Ren, Hongbin] Jiaxing Tradit Chinese Med Hosp, Dept Acupuncture & Moxibust, Jiaxing 314000, Peoples R China.
RP Fan, DH (corresponding author), Jiaxing Tradit Chinese Med Hosp, Dept Acupuncture & Moxibust, Jiaxing 314000, Peoples R China.
EM verysupersb@163.com; me6095@163.com
FU Zhejiang Provincial Traditional Chinese Medicine Science and Technology
   Project [2024ZL1047]
FX Zhejiang Provincial Traditional Chinese Medicine Science and Technology
   Project (2024ZL1047).
CR Cheng L., 2022, Chin J Tradit Chin Med Emerg, V31, P317
   Dou Ting-Ting, 2023, Zhongguo Zhen Jiu, V43, P639, DOI 10.13703/j.0255-2930.20220719-k0003
   Gao L., 2016, Chin Gen Pract, V19, P3589
   Ge H., 2023, J Rehabil, V33, P65
   Jiang L., 2021, Bull Tradit Chin Med, V20, P50
   Jiang Z., 2024, Mod J Integr Tradit Chin West Med, V33, P1770
   Kellis E, 2024, J SPORT SCI MED, V23, P436, DOI 10.52082/jssm.2024.436
   Kohpe Kapseu Stephane, 2022, Int J Surg Case Rep, V98, P107545, DOI [10.1016/j.ijscr.2022.107545, 10.1016/j.ijscr.2022.107545]
   Li Q., 2024, Chin J Tradit Chin Med Emerg, V33, P870
   Li Y., 2023, Tianjin J Tradit Chin Med, V40, P1018
   Lin Q., 2023, Chin J Tradit Chin Med Emerg, V32, P1764
   Lin W., 2023, Shaanxi J Tradit Chin Med, V44, P112
   Liu L., 2019, West J Tradit Chin Med, V32, P117
   Liu S., 2022, Guiding J Tradit Chin Med Pharm, V28, P64
   Liu Y., 2020, J Liaoning Univ Tradit Chin Med, V22, P155
   Ma JY, 2024, FRONT SPORTS ACT LIV, V6, DOI 10.3389/fspor.2024.1383228
   Ma M., 2023, J Nurs, V38, P52
   Medani K, 2021, INT J OCCUP MED ENV, V34, P111, DOI 10.13075/ijomeh.1896.01602
   Ren J., 2021, Sichuan J Tradit Chin Med, V39, P179
   Wang F, 2023, J ORTHOP SURG RES, V18, DOI 10.1186/s13018-023-04140-6
   Wang S., 2020, Chinese J Rehabil, V35, P179
   [肖薇 Xiao Wei], 2020, [中国中医基础医学杂志, Chinese Journal of Basic Medicine in Traditional Chinese Medicine], V26, P1743
   Ye Y., 2021, New J Tradit Chin Med, V53, P178
   You Y., 2019, Guiding J Tradit Chin Med Pharm, V25, P22
   Zhan Z., 2016, Liaoning J Tradit Chin Med, V43, P2624
NR 25
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC 26
PY 2025
VL 104
IS 52
AR e46161
DI 10.1097/MD.0000000000046161
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AJ5YN
UT WOS:001649664100042
PM 41465915
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Chiu, WS
   Lu, YW
   Lien, TH
AF Chiu, Wen-Shan
   Lu, Yu-Wen
   Lien, Ting-Hsuan
TI Iatrogenic Pneumothorax during Acupuncture: Case Report
SO MEDICINA-LITHUANIA
LA English
DT Article
DE acupuncture; iatrogenic pneumothorax; chronic pulmonary diseases;
   imaging
ID CATAMENIAL PNEUMOTHORAX; SAFETY
AB Acupuncture treatment in local areas is commonly used to treat pain or soreness; however, acupuncture around the neck or shoulder may be a risk factor for pneumothorax. Herein, we report two cases of iatrogenic pneumothorax after acupuncture. These points indicate that physicians should be aware of these risk factors through history-taking before acupuncture. Chronic pulmonary diseases, such as chronic bronchitis, emphysema, tuberculosis, lung cancer, pneumonia, and thoracic surgery, may be associated with a higher risk of iatrogenic pneumothorax after acupuncture. Even if the incidence of pneumothorax should be low under caution and fully evaluated, it is still recommended to arrange further imaging examinations to rule out the possibility of iatrogenic pneumothorax.
C1 [Chiu, Wen-Shan; Lu, Yu-Wen; Lien, Ting-Hsuan] Show Chawn Mem Hosp, Dept Chinese Med, Changhua 500, Taiwan.
RP Lu, YW; Lien, TH (corresponding author), Show Chawn Mem Hosp, Dept Chinese Med, Changhua 500, Taiwan.
EM luffy1964@gmail.com; tiffiny5267@gmail.com
CR Ahiskalioglu EO, 2016, J BACK MUSCULOSKELET, V29, P895, DOI 10.3233/BMR-160666
   Aissa S, 2017, PAN AFR MED J, V27, DOI 10.11604/pamj.2017.27.112.8007
   Chen HN, 2018, J ACUPUNCT MERIDIAN, V11, P355
   Chi LM, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/7358918
   Chou PC, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-007819
   Chou PC, 2011, J ALTERN COMPLEM MED, V17, P199, DOI 10.1089/acm.2010.0192
   Chu H, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/2308102
   Furuse N, 2017, MED ACUPUNCT, V29, P155, DOI 10.1089/acu.2017.1230
   Ghisalberti M, 2020, HEART LUNG CIRC, V29, P1648, DOI 10.1016/j.hlc.2020.05.107
   Gilday C, 2021, TOP COMPANION ANIM M, V45, DOI 10.1016/j.tcam.2021.100563
   He WJ, 2012, J ALTERN COMPLEM MED, V18, P892, DOI 10.1089/acm.2011.0825
   Hou XJ, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000025666
   Kaptchuk TJ, 2002, ANN INTERN MED, V136, P374, DOI 10.7326/0003-4819-136-5-200203050-00010
   Kwon CY, 2018, INTEGR MED RES, V7, P219
   Lin SK, 2019, ACUPUNCT MED, V37, P332, DOI 10.1136/acupmed-2018-011697
   Liu L, 2015, ARCH PHYS MED REHAB, V96, P944, DOI 10.1016/j.apmr.2014.12.015
   Mohammad Nurashikin, 2018, BMJ Case Rep, V2018, DOI [10.1136/bcr-2017-221550, 10.1136/bcr-2017-221550]
   Quercia R, 2023, FRONT SURG, V10, DOI 10.3389/fsurg.2023.1156465
   Th'ng F, 2022, INT J EMERG MED, V15, DOI 10.1186/s12245-022-00455-z
   Vickers A, 2002, QUAL SAF HEALTH CARE, V11, P92, DOI 10.1136/qhc.11.1.92
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Voláková E, 2017, CES GYNEKOL, V82, P308
   Witt CM, 2009, FORSCH KOMPLEMENTMED, V16, P91, DOI 10.1159/000209315
   Yamashita H, 2008, EVID-BASED COMPL ALT, V5, P391, DOI 10.1093/ecam/nem086
   Yuan QL, 2016, SCI REP-UK, V6, DOI 10.1038/srep30675
   Zuo G, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000017974
NR 26
TC 6
Z9 7
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JUN
PY 2023
VL 59
IS 6
AR 1100
DI 10.3390/medicina59061100
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA K2EM2
UT WOS:001014624000001
PM 37374304
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Shang, R
   Pan, T
   Wang, FY
   Jin, H
   Nan, X
   Song, CY
AF Shang, Rui
   Pan, Ting
   Wang, Fengyang
   Jin, Hui
   Nan, Xi
   Song, Chenyu
TI Current and future trends of acupuncture as an adjuvant therapy in
   cancer: A bibliometric and visual analysis
SO MEDICINE
LA English
DT Article
DE acupuncture; bibliometric analysis; cancer; current state of research
ID BREAST-CANCER
AB Background:Acupuncture, as one of the representatives of complementary therapies, is often used as an adjunctive therapy in the treatment of cancer and related complications with beneficial results.Methods:We selected the Web of Science Core Collection (WOSCC) database as the data source and searched to obtain relevant literatures on the application of acupuncture in cancer treatment. The relevant literature was analyzed using CiteSpace (version 6.1.R6) and VOSviewer (version 1.6.20).Results:A total of 592 publications were included, with an overall upward trend in the number of publications. There were 135 countries or institutions involved, with China as the most published country. There were 1888 related institutions, and Memorial Sloan Kettering Cancer Center was the institution with the most publications. A total of 3067 authors were involved, and there were obvious collaborations between authors. There were 190 related journals, and J Clin Oncol was the most cited journal. The most frequently occurring keywords were breast cancer and management, but also other related topics such as quality of life, chemotherapy, and complementary.Conclusion:Acupuncture is gaining increasing attention as an adjunctive therapy in cancer treatment programs. Currently, relevant research focuses on acupuncture to alleviate cancer-induced comorbid symptoms, such as pain and insomnia. Future research is gradually shifting toward spiritual care, Colorectal Cancer Surgery, and systematic review.
C1 [Shang, Rui; Jin, Hui; Nan, Xi; Song, Chenyu] JiLin Canc Hosp, Changchun, Jilin, Peoples R China.
   [Pan, Ting] Changchun Univ Chinese Med, Affiliated Hosp, Changchun, Jilin, Peoples R China.
   [Wang, Fengyang] Changchun Univ, Changchun, Jilin, Peoples R China.
C3 Changchun University of Chinese Medicine; Changchun University
RP Song, CY (corresponding author), Jilin Canc Hosp, Changchun High Tech Dev Zone, Changchun 130117, Jilin, Peoples R China.
EM shangrui364159254@qq.com; 610973831@qq.com; 651442536@qq.com;
   1198899601@qq.com; shangrui364159254@163.com
CR Arbyn M, 2020, LANCET GLOB HEALTH, V8, pE191, DOI 10.1016/S2214-109X(19)30482-6
   Bao T, 2023, BREAST CANCER RES TR, V202, P287, DOI 10.1007/s10549-023-07072-1
   Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Bray F, 2022, LANCET ONCOL, V23, P719, DOI [10.1016/S1470-2045(22)00270-, 10.1016/S1470-2045(22)00270-4]
   Bray F, 2021, CANCER-AM CANCER SOC, V127, P3029, DOI 10.1002/cncr.33587
   Chase DM, 2024, BMC WOMENS HEALTH, V24, DOI 10.1186/s12905-024-02977-5
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Choi TY, 2017, INTEGR CANCER THER, V16, P135, DOI 10.1177/1534735416664172
   de Sousa TR, 2023, J CLIN NURS, V32, P6917, DOI 10.1111/jocn.16812
   Fadelu T, 2021, CANCER-AM CANCER SOC, V127, P2864, DOI 10.1002/cncr.33586
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Garland SN, 2019, JNCI-J NATL CANCER I, V111, P1323, DOI 10.1093/jnci/djz050
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Mao JJ, 2021, JAMA ONCOL, V7, P720, DOI 10.1001/jamaoncol.2021.0310
   Wang HZ, 2023, J PAIN RES, V16, P4165, DOI 10.2147/JPR.S442151
   Wang XY, 2024, BMC GASTROENTEROL, V24, DOI 10.1186/s12876-024-03168-0
   Yang MX, 2023, CANCER-AM CANCER SOC, V129, P2084, DOI 10.1002/cncr.34766
   Yuan YJ, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-56895-5
   Zhang XW, 2022, PHYTOMEDICINE, V106, DOI 10.1016/j.phymed.2022.154430
   Zhang Y, 2018, SUPPORT CARE CANCER, V26, P415, DOI 10.1007/s00520-017-3955-6
NR 23
TC 0
Z9 0
U1 1
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL 19
PY 2024
VL 103
IS 29
AR e38663
DI 10.1097/MD.0000000000038663
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZB5V3
UT WOS:001272852400055
PM 39029068
OA Green Published, gold
DA 2026-01-16
ER

PT J
AU D'Alessandro, EG
   Nagy, DRN
   de Brito, CMM
   Almeida, EPM
   Battistella, LR
   Cecatto, RB
AF D'Alessandro, Eduardo Guilherme
   Nebuloni Nagy, Daniela Ribeiro
   Moran de Brito, Christina May
   Marinho Almeida, Elisangela Pinto
   Battistella, Linamara Rizzo
   Cecatto, Rebeca Boltes
TI Acupuncture for chemotherapy-induced peripheral neuropathy: a randomised
   controlled pilot study
SO BMJ SUPPORTIVE & PALLIATIVE CARE
LA English
DT Article
DE neuropathy; chemotherapy; quality of life; acupuncture; rehabilitation
ID MANAGEMENT; CANCER; NEUROTOXICITY; CIPN
AB Chemotherapy-induced peripheral neuropathy (CIPN) can cause loss of independence and poor quality of life (QoL) due to severe disabilities, but in spite of its importance there is still a lack of data for the management of CIPN. Acupuncture has showed promising results and may be a cost-effective option for the treatment.
   Objectives To evaluate the effect of acupuncture treatment on neurological symptoms of CIPN and QoL of oncological patients.
   Methods We performed a clinical, single-centre, randomised and controlled pilot study that involved 33 adult patients with cancer and CIPN randomised into two groups (control and acupuncture treated with 10 sessions, two times per week). Both groups were subjected to a complete physical examination and clinical assessment with National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Scale V.2.0, FIM Scale, European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core (EORTC QLQ-C30) Scale and Visual Analogue Scale for pain before and 5 weeks after treatment.
   Results There were no adverse events, and we found statistical differences in groups in physical (p=0.03) and function (p=0.04) domains of EORTC QLQ-C30 when comparing control and acupuncture groups. About NCI CTCAE Scale and neuropathy sensory symptoms, we found better results in acupuncture group, comparing pretreatment and post-treatment analyses (p=0.01). In control group, we have no differences after 5 weeks (p=0.11).
   Conclusion Although these results suggest an interesting effect of acupuncture on this patient population, the clinical significance has remained unclear. Given the tendency towards benefit and the lack of adverse effects, the authors recommend a follow-up acupuncture trial using higher follow-up time and better sample size.
C1 [D'Alessandro, Eduardo Guilherme; Nebuloni Nagy, Daniela Ribeiro] Univ Sao Paulo, Inst Canc, Hosp Clin, Fac Med, Sao Paulo, Brazil.
   [Moran de Brito, Christina May; Marinho Almeida, Elisangela Pinto; Cecatto, Rebeca Boltes] Univ Sao Paulo, Inst Canc, Rehabil Dept, Hosp Clin,Fac Med, Sao Paulo, Brazil.
   [Moran de Brito, Christina May] Hosp Sirio Libanes, Rehabil Serv, Sao Paulo, Brazil.
   [Battistella, Linamara Rizzo] Univ Sao Paulo, Fac Med, Dept Legal Med Med Eth Social & Work Med, Sao Paulo, Brazil.
   [Battistella, Linamara Rizzo] Univ Sao Paulo, Inst Med Fis & Reabilitacao, Fac Med, Hosp Clin IMREA HCFMUSP, Sao Paulo, Brazil.
   [Cecatto, Rebeca Boltes] Univ Nove Julho, Sch Med, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Hospital Sirio
   Libanes; Universidade de Sao Paulo; Universidade de Sao Paulo;
   Universidade Nove de Julho
RP Cecatto, RB (corresponding author), Inst Canc Estado Sao Paulo Octavio Frias de Olive, BR-05020000 Sao Paulo, Brazil.
EM rebeca.boltes@gmail.com
RI Cecatto, Rebeca/B-7338-2013; Moran de Brito, Christina May/I-7269-2012;
   Rizzo Battistella, Linamara/E-5131-2013
OI Cecatto, Rebeca/0000-0001-5675-6665; Moran de Brito, Christina
   May/0000-0003-3775-6533; Rizzo Battistella, Linamara/0000-0001-5275-0733
FU CNPQ/Brazil [401459/2013-6]
FX Supported by grant from CNPQ/Brazil Process Number 401459/2013--6
   (Oct/2013).
CR Ambrósio EMM, 2012, COMPLEMENT THER MED, V20, P364, DOI 10.1016/j.ctim.2012.05.002
   Argyriou AA, 2012, CRIT REV ONCOL HEMAT, V82, P51, DOI 10.1016/j.critrevonc.2011.04.012
   Australian Acupuncture and Chinese Medicine Association LTD, 2017, AC EV PROJ PLAIN ENG
   Behrend Susan Weiss, 2014, Oncol Nurs Forum, V41, P559, DOI 10.1188/14.ONF.559-560
   Center for health information and analysis, 2015, MAND BEN REV H B 397
   Deadman P., 1998, A manual of acupuncture
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Dropcho EJ, 2010, SEMIN NEUROL, V30, P273, DOI 10.1055/s-0030-1255217
   Fayers P, 2002, EUR J CANCER, V38, pS125
   Grisold W, 2012, NEURO-ONCOLOGY, V14, P45, DOI 10.1093/neuonc/nos203
   Hammack JE, 2002, PAIN, V98, P195, DOI 10.1016/S0304-3959(02)00047-7
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   Hausheer FH, 2006, SEMIN ONCOL, V33, P15, DOI 10.1053/j.seminoncol.2005.12.010
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Hsieh YL, 2016, ACUPUNCT MED, V34, P398, DOI 10.1136/acupmed-2016-011112
   Kim JH, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-254
   LANGOHR HD, 1982, EUR NEUROL, V21, P309, DOI 10.1159/000115497
   Lao Lixing, 2006, J Soc Integr Oncol, V4, P13
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Majithia N, 2016, SUPPORT CARE CANCER, V24, P1439, DOI 10.1007/s00520-015-3063-4
   Molassiotis A, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-5302-4
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Riberto M, 2013, DISABIL REHABIL, V35, P367, DOI 10.3109/09638288.2012.694573
   Rostock M, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/349653
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Smith EML, 2013, QUAL LIFE RES, V22, P2787, DOI 10.1007/s11136-013-0379-8
   Stubblefield MD, 2009, J NATL COMPR CANC NE, V7, pS1, DOI 10.6004/jnccn.2009.0078
   Tofthagen C, 2012, ONCOL NURS FORUM, V39, pE416, DOI 10.1188/12.ONF.E416-E424
NR 28
TC 36
Z9 41
U1 9
U2 56
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2045-435X
EI 2045-4368
J9 BMJ SUPPORT PALLIAT
JI BMJ Support. Palliat. Care
PD MAR
PY 2022
VL 12
IS 1
BP 64
EP 72
DI 10.1136/bmjspcare-2018-001542
PG 9
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA ZF7IB
UT WOS:000759737800013
PM 31256014
DA 2026-01-16
ER

PT J
AU Li, DX
   Yoo, JH
   Kim, SK
AF Li, Daxian
   Yoo, Ju Hyuk
   Kim, Sun Kwang
TI Long-Lasting and Additive Analgesic Effects of Combined Treatment of Bee
   Venom Acupuncture and Venlafaxine on Paclitaxel-Induced Allodynia in
   Mice
SO TOXINS
LA English
DT Article
DE bee venom acupuncture; venlafaxine; combination therapy; paclitaxel;
   allodynia
ID INDUCED PERIPHERAL NEUROPATHY; CHRONIC PAIN; MOUSE MODEL; COMBINATION;
   GABAPENTIN; MECHANISMS; MANAGEMENT; RECEPTORS; ELECTROACUPUNCTURE;
   NOCICEPTION
AB Paclitaxel, a primary chemotherapeutic agent used to treat numerous solid malignancies, is commonly associated with debilitating peripheral neuropathy. However, a satisfactory gold-standard monotherapy for this neuropathic pain is not currently available. A combination strategy of two or more medications with different properties may achieve more beneficial effects than monotherapy. Thus, we investigated the analgesic efficacies and spinal mechanisms of the combination strategy, including bee venom acupuncture (BVA) and venlafaxine (VLX) against paclitaxel-induced allodynia in mice. Four intraperitoneal infusions of paclitaxel on alternating days (2 mg/kg/day) induced cold and mechanical allodynia for at least 1 week as assessed using acetone and the von Frey hair test, respectively. Co-treatment of BVA (1.0 mg/kg, s.c., ST36) with VLX (40 mg/kg, i.p.) at the medium dose produced a longer-lasting and additive effect than each monotherapy at the highest dose (BVA, 2.5 mg/kg; VLX, 60 mg/kg). Spinal pre-administration of idazoxan (alpha(2)-adrenergic receptor antagonist, 10 mu g), methysergide (mixed 5-HT1/5-HT2 receptor antagonist, 10 mu g), or MDL-72222 (5-HT3 receptor antagonist, 10 mu g) abolished this analgesia. These results suggest that the combination therapy with BVA and VLX produces long-lasting and additive analgesic effects on paclitaxel-induced allodynia, via the spinal noradrenergic and serotonergic mechanism, providing a promising clinical strategy.
C1 [Li, Daxian; Kim, Sun Kwang] Kyung Hee Univ, Grad Sch, Dept Sci Korean Med, Seoul 02447, South Korea.
   [Yoo, Ju Hyuk; Kim, Sun Kwang] Kyung Hee Univ, Grad Sch, Dept East West Med, Seoul 02447, South Korea.
   [Kim, Sun Kwang] Kyung Hee Univ, Dept Physiol, Coll Korean Med, Seoul 02447, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University
RP Kim, SK (corresponding author), Kyung Hee Univ, Grad Sch, Dept Sci Korean Med, Seoul 02447, South Korea.; Kim, SK (corresponding author), Kyung Hee Univ, Grad Sch, Dept East West Med, Seoul 02447, South Korea.; Kim, SK (corresponding author), Kyung Hee Univ, Dept Physiol, Coll Korean Med, Seoul 02447, South Korea.
EM lidaxian721@naver.com; impera27@naver.com; skkim77@khu.ac.kr
RI ; Kim, Sun Kwang/AAM-1289-2020
OI Li, Daxian/0000-0003-1327-5866; Kim, Sun Kwang/0000-0002-2649-6652
FU National Research Foundation of Korea (NRF) - Korea government
   [NRF-2017M3A9E4057926]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (NRF-2017M3A9E4057926).
CR ARCHER T, 1986, EUR J PHARMACOL, V120, P295, DOI 10.1016/0014-2999(86)90470-X
   Beery AK, 2018, CURR OPIN BEHAV SCI, V23, P143, DOI 10.1016/j.cobeha.2018.06.016
   Boyette-Davis JA, 2018, PAIN MANAG, V8, P363, DOI 10.2217/pmt-2018-0020
   Cegielska-Perun K, 2013, PHARMACOLOGY, V91, P69, DOI 10.1159/000345035
   Chaparro LE, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008943.pub2
   Chen J, 2010, PROG NEUROBIOL, V92, P151, DOI 10.1016/j.pneurobio.2010.06.006
   Cherniack EP, 2018, TOXICON, V154, P74, DOI 10.1016/j.toxicon.2018.09.013
   Choi J, 2017, TOXINS, V9, DOI 10.3390/toxins9110351
   Choi S, 2019, TOXINS, V11, DOI 10.3390/toxins11070396
   Deng YK, 2016, BMC ANESTHESIOL, V16, DOI 10.1186/s12871-015-0150-5
   Dougherty PM, 2004, PAIN, V109, P132, DOI 10.1016/j.pain.2004.01.021
   Durand JP, 2005, ANTI-CANCER DRUG, V16, P587, DOI 10.1097/00001813-200506000-00015
   Eisenberg E, 2014, CURR PAIN HEADACHE R, V18, DOI 10.1007/s11916-014-0463-y
   Finnerup NB, 2015, LANCET NEUROL, V14, P162, DOI 10.1016/S1474-4422(14)70251-0
   Folkesson A, 2010, SCAND J PAIN, V1, P91, DOI 10.1016/j.sjpain.2009.12.001
   Gilron I, 2005, NEW ENGL J MED, V352, P1324, DOI 10.1056/NEJMoa042580
   Gilron I, 2013, LANCET NEUROL, V12, P1084, DOI 10.1016/S1474-4422(13)70193-5
   Godoy MCM, 2004, EUR J PHARMACOL, V496, P93, DOI 10.1016/j.ejphar.2004.05.045
   Hache G, 2015, EUR J PAIN, V19, P322, DOI 10.1002/ejp.550
   Hajhashemi V, 2014, EUR J PHARMACOL, V738, P230, DOI 10.1016/j.ejphar.2014.04.046
   Hanna M, 2008, EUR J PAIN, V12, P804, DOI 10.1016/j.ejpain.2007.12.010
   Hershman DL, 2014, J ONCOL PRACT, V10, pE421, DOI 10.1200/JOP.2014.001776
   HYLDEN JLK, 1980, EUR J PHARMACOL, V67, P313, DOI 10.1016/0014-2999(80)90515-4
   Kawamura M, 1998, LIFE SCI, V62, P2181, DOI 10.1016/S0024-3205(98)00195-7
   Kerckhove N, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00086
   Kim W, 2016, TOXINS, V8, DOI 10.3390/toxins8020033
   Kus T, 2016, SUPPORT CARE CANCER, V24, P2085, DOI 10.1007/s00520-015-3009-x
   Lee JH, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-471
   Li DX, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071652
   Li D, 2015, TOXINS, V7, P2422, DOI 10.3390/toxins7072422
   Lim BS, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/369324
   Liu ZY, 2002, NEUROSCIENCE, V112, P399, DOI 10.1016/S0306-4522(02)00038-6
   Lockwood SM, 2019, J NEUROPHYSIOL, V121, P96, DOI 10.1152/jn.00613.2018
   Lu KW, 2016, SCI REP-UK, V6, DOI 10.1038/srep22123
   Mao JR, 2011, J PAIN, V12, P157, DOI 10.1016/j.jpain.2010.07.006
   Millan MJ, 2002, PROG NEUROBIOL, V66, P355, DOI 10.1016/S0301-0082(02)00009-6
   Moulin DE, 2014, PAIN RES MANAG, V19, P328
   NAKAGAWA I, 1990, ANESTHESIOLOGY, V73, P474, DOI 10.1097/00000542-199009000-00017
   Park JW, 2012, INTEGR CANCER THER, V11, P166, DOI 10.1177/1534735411413265
   Pedersen LH, 2005, PSYCHOPHARMACOLOGY, V182, P551, DOI 10.1007/s00213-005-0120-6
   Polomano RC, 2001, PAIN, V94, P293, DOI 10.1016/S0304-3959(01)00363-3
   Seo BK, 2017, TOXINS, V9, DOI 10.3390/toxins9110361
   Starobova H, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00174
   Trouvin AP, 2017, CLIN THER, V39, P1104, DOI 10.1016/j.clinthera.2017.05.347
   Wiesenfeld-Hallin Zsuzsanna, 2005, Gend Med, V2, P137, DOI 10.1016/S1550-8579(05)80042-7
   Yeo JH, 2016, J PAIN, V17, P298, DOI 10.1016/j.jpain.2015.10.018
   Yoon J, 2012, J ACUPUNCT MERIDIAN, V5, P156, DOI [10.1016/j.jams.2012.05.003, 10.106/j.jams.2012.05.003]
   Yoshimura M, 2006, J PHARMACOL SCI, V101, P107, DOI 10.1254/jphs.CRJ06008X
   Yoshimura M, 2017, PAIN, V158, pS85, DOI 10.1097/j.pain.0000000000000844
   Zeng YJ, 2018, LASER MED SCI, V33, P295, DOI 10.1007/s10103-017-2367-7
   Zhang S, 2018, TOXICON, V148, P64, DOI 10.1016/j.toxicon.2018.04.012
   Zuo CY, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/1807287
NR 52
TC 18
Z9 18
U1 2
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6651
J9 TOXINS
JI Toxins
PD OCT
PY 2020
VL 12
IS 10
AR 620
DI 10.3390/toxins12100620
PG 12
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA OL6IT
UT WOS:000585441800001
PM 32998357
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Chen, YQ
   Song, HH
   Chen, MY
   Xu, H
AF Chen, Yuqin
   Song, Huaihua
   Chen, Mingyu
   Xu, Hua
TI The role of acupotomy in treatment of patients with lumbar spinal
   stenosis A protocol for a randomized study (Publication with Expression
   of Concern. See vol. 104, 2025)
SO MEDICINE
LA English
DT Article; Publication with Expression of Concern
DE acupuncture; lumbar spinal stenosis; pain control; protocol
ID LOW-BACK-PAIN; ACUPUNCTURE; GUIDELINE; DIAGNOSIS; EXERCISE
AB Background: Currently, there is some clinical evidence supporting the use of acupuncture in alleviating pain and dysfunction in patients with lumbar spinal stenosis (LSS). However, the question of whether acupuncture could be efficacious for ageing patients remains unanswered. We designed a randomized controlled study to evaluate the safety and feasibility of acupuncture for participants with symptomatic LSS. Methods: This study is a randomized, single-blind, noninferiority trial. This clinical trial was approved by the Linyi Cancer Hospital. We received informed consent from all patients before surgery. In preparing this report, we adhered to the Consolidated Standards of Reporting Trials guidelines. We randomized consented study participants on a 1:1 ratio to one of two study groups (acupuncture and control groups) using a computer-generated list of random numbers in varying block sizes. Three outcome measures were selected to evaluate the effectiveness and safety of the treatment: visual analogue score and Oswestry disability index, and complicatins. AP Results: The hypothesis was that the acupuncture group would achieve acceptable clinical outcomes as compared to the control group in LSS.
C1 [Chen, Yuqin] Linyi Cent Hosp, Dept Rehabil, Linyi, Shandong, Peoples R China.
   [Song, Huaihua] Third Peoples Hosp Linyi, Dept Obstet & Gynecol, Linyi, Shandong, Peoples R China.
   [Chen, Mingyu] Linyi Cent Hosp, Dept Neurol, Linyi, Shandong, Peoples R China.
   [Xu, Hua] Linyi Canc Hosp, Dept Bone Oncol, Linyi, Shandong, Peoples R China.
RP Xu, H (corresponding author), Linyi Canc Hosp, Dept Bone Oncol, Linyi, Shandong, Peoples R China.
EM huaxuczyy9208@sina.com
RI Chen, Mingyu/R-6690-2019
FU National Natural Science Foundation of China [81774218]
FX This study is funded by National Natural Science Foundation of China
   (No. 81774218).
CR Airaksinen O, 2006, EUR SPINE J, V15, pS192, DOI 10.1007/s00586-006-1072-1
   Benoist M, 2002, JOINT BONE SPINE, V69, P450, DOI 10.1016/S1297-319X(02)00429-3
   Bodack MP, 2001, CLIN ORTHOP RELAT R, P144
   Burgstaller JM, 2020, SPINE PHILA PA 1976
   Chou R, 2007, ANN INTERN MED, V147, P478, DOI 10.7326/0003-4819-147-7-200710020-00006
   CUCKLER JM, 1985, J BONE JOINT SURG AM, V67A, P63, DOI 10.2106/00004623-198567010-00009
   Hopton AK, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2011-000456
   Hunter RF, 2012, CLIN J PAIN, V28, P259, DOI 10.1097/AJP.0b013e3182274018
   Kim KH, 2013, COMPLEMENT THER MED, V21, P535, DOI 10.1016/j.ctim.2013.08.007
   Koes BW, 1995, PAIN, V63, P279, DOI 10.1016/0304-3959(95)00124-7
   Kreiner DS, 2013, SPINE J, V13, P734, DOI 10.1016/j.spinee.2012.11.059
   Kwon CY, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016662
   Liu LZ, 2017, CLIN REHABIL, V31, P1592, DOI 10.1177/0269215517705690
   Lurie J, 2016, BMJ-BRIT MED J, V352, DOI 10.1136/bmj.h6234
   Mazanec DJ, 2002, CLEV CLIN J MED, V69, P909, DOI 10.3949/ccjm.69.11.909
   Rittenberg Joshua D, 2003, Phys Med Rehabil Clin N Am, V14, P111, DOI 10.1016/S1047-9651(02)00082-7
   Roelofs PDDM, 2008, SPINE, V33, P1766, DOI 10.1097/BRS.0b013e31817e69d3
   Whitman JM, 2006, SPINE, V31, P2541, DOI 10.1097/01.brs.0000241136.98159.8c
   WILLNER S, 1985, ACTA ORTHOP SCAND, V56, P40, DOI 10.3109/17453678508992977
   Xue CCL, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-105
NR 20
TC 61
Z9 63
U1 3
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL 31
PY 2020
VL 99
IS 31
AR e21444
DI 10.1097/MD.0000000000021444
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA NE6EZ
UT WOS:000562693800090
PM 32756160
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, Q
   Zhao, Y
   Cheng, GY
AF Zhang, Qi
   Zhao, Yue
   Cheng, Guang-Yu
TI Effect of negative mood, serum inflammatory factors, miR-155, and
   brain-derived neurotrophic factor
SO WORLD JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Syndrome differentiation acupuncture; Abdominal surgery; Depression;
   Negative mood; Serum inflammatory factor; Tiny RNA-155
ID DEPRESSION
AB BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress, which can hinder their rehabilitation. Acupuncture has shown potential to relieve this condition. AIM To analyze the mechanism by which acupuncture relieves postoperative depression in patients post-abdominal surgery. METHODS Abdominal postoperative patients with depression between January 2015 and December 2023 at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were enrolled. Patients were divided into two groups using the random throwing method: Observation (250 cases, fluoxetine hydrochloride + acupuncture treatment) and control (250 cases, fluoxetine hydrochloride treatment). Changes in negative emotions Hamilton Depression Scale 24, serum inflammatory factors [tumor necrosis factor alpha, interleukin (IL)-1 beta, IL-6], miR-155 expression levels, and BDNF levels were assessed. RESULTS Significant improvements were observed in the observation group compared to the control group in all assessed parameters after six weeks (P < 0.05). This suggests that the combination of fluoxetine hydrochloride and acupuncture may be more effective in managing postoperative depression than medication alone. CONCLUSION Acupuncture complies with the principle of traditional Chinese medicine syndrome differentiation and ensures the pertinence and effectiveness of treatment. In addition, it not only actively improves depressive symptoms but also effectively regulates the serum level of inflammatory factors.
C1 [Zhang, Qi] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Prevent & Treatment Ctr, Harbin 150040, Heilongjiang, Peoples R China.
   [Zhao, Yue] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Med, Harbin 150040, Heilongjiang, Peoples R China.
   [Cheng, Guang-Yu] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Tradit Chinese Med Translat Med Res Ctr, 6 Heping Rd, Harbin 150040, Heilongjiang, Peoples R China.
C3 Heilongjiang University of Chinese Medicine; Heilongjiang University of
   Chinese Medicine; Heilongjiang University of Chinese Medicine
RP Cheng, GY (corresponding author), Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Tradit Chinese Med Translat Med Res Ctr, 6 Heping Rd, Harbin 150040, Heilongjiang, Peoples R China.
EM chengguangyu@hljucm.edu.cn
CR Colucci-D'Amato L, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207777
   Dai J, 2020, EUR REV MED PHARMACO, V24, P1398, DOI 10.26355/eurrev_202002_20197
   Kelly KM, 2021, BRAIN BEHAV IMMUN, V95, P106, DOI 10.1016/j.bbi.2021.02.019
   Li MX, 2020, COMPLEMENT THER MED, V50, DOI 10.1016/j.ctim.2019.102202
   McAllister-Williams RH, 2006, BRIT J HOSP MED, V67, P60, DOI 10.12968/hmed.2006.67.2.20461
   Sardar M, 2022, COMPUT BIOL CHEM, V101, DOI 10.1016/j.compbiolchem.2022.107774
   Shen DD, 2021, NEUROSCI LETT, V746, DOI 10.1016/j.neulet.2020.135585
   Szoke-Kovacs Zsombor, 2020, Neuropsychopharmacol Hung, V22, P4
   Yang NN, 2022, CURR NEUROPHARMACOL, V20, P738, DOI 10.2174/1570159X19666210609162809
   Yao L, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.518837
   Zimmerman M, 2013, J AFFECT DISORDERS, V150, P384, DOI 10.1016/j.jad.2013.04.028
NR 11
TC 2
Z9 2
U1 1
U2 4
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2220-3206
J9 WORLD J PSYCHIATR
JI World J. Psychiatr.
PD FEB 19
PY 2025
VL 15
IS 2
AR 99573
DI 10.5498/wjp.v15.i2.99573
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA U7J6L
UT WOS:001413514100003
PM 39974477
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Avis, NE
   Coeytaux, RR
AF Avis, Nancy E.
   Coeytaux, Remy R.
TI The role of acupuncture in treating menopausal hot flashes
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Editorial Material
ID ESTROGEN PLUS PROGESTIN; MIDDLE-AGED WOMEN; QUALITY-OF-LIFE;
   LOW-BACK-PAIN; POSTMENOPAUSAL WOMEN; BREAST-CANCER; PATIENT
   EXPECTATIONS; APPLIED RELAXATION; HORMONE-THERAPY; SYMPTOMS
C1 [Avis, Nancy E.] Wake Forest Univ, Sch Med, Div Publ Hlth Sci, Dept Social Sci & Hlth Policy, Winston Salem, NC 27109 USA.
   [Coeytaux, Remy R.] Duke Univ, Sch Med, Dept Community & Family Med, Durham, NC USA.
C3 Wake Forest University; Duke University
RP Avis, NE (corresponding author), Wake Forest Univ, Sch Med, Div Publ Hlth Sci, Dept Social Sci & Hlth Policy, Winston Salem, NC 27109 USA.
CR Avis N E, 1997, Womens Health, V3, P103
   Avis NE, 2008, MENOPAUSE, V15, P1070, DOI 10.1097/gme.0b013e31816d5b03
   Avis NE, 2003, MED CARE, V41, P1262, DOI 10.1097/01.MLR.0000093479.39115.AF
   Barnabei VM, 2002, OBSTET GYNECOL, V100, P1209, DOI 10.1016/S0029-7844(02)02369-4
   Birch S., 2003, CLIN ACUPUNCTURE ORI, V4, P59, DOI DOI 10.1016/S1461-1449(03)00025-2
   Borud EK, 2009, MENOPAUSE, V16, P484, DOI 10.1097/gme.0b013e31818c02ad
   Bosworth HB, 2005, J BEHAV MED, V28, P105, DOI 10.1007/s10865-005-2721-2
   Brinkhaus B, 2006, ARCH INTERN MED, V166, P450
   Cherkin DC, 2009, ARCH INTERN MED, V169, P858, DOI 10.1001/archinternmed.2009.65
   Cho SH, 2009, MENOPAUSE, V16, P1065, DOI 10.1097/gme.0b013e3181a48abd
   DALY E, 1993, BRIT MED J, V307, P836, DOI 10.1136/bmj.307.6908.836
   Deng G, 2007, J CLIN ONCOL, V25, P5584, DOI 10.1200/JCO.2007.12.0774
   Frisk J, 2008, CLIMACTERIC, V11, P166, DOI 10.1080/13697130801958709
   Fuh JL, 2003, QUAL LIFE RES, V12, P53, DOI 10.1023/A:1022074602928
   Guthrie JR, 2003, CLIMACTERIC, V6, P112, DOI 10.1080/713605371
   Huang MI, 2006, FERTIL STERIL, V86, P700, DOI 10.1016/j.fertnstert.2006.02.100
   JOHANNES CB, 1994, AM J EPIDEMIOL, V140, P439, DOI 10.1093/oxfordjournals.aje.a117266
   Kalauokalani D, 2001, SPINE, V26, P1418, DOI 10.1097/00007632-200107010-00005
   Kerr EA, 2005, ANN INTERN MED, V142, P154, DOI 10.7326/0003-4819-142-2-200501180-00021
   Kessel B, 2004, ENDOCRIN METAB CLIN, V33, P717, DOI 10.1016/j.ecl.2004.07.004
   Kim KH, 2010, MENOPAUSE, V17, P269, DOI 10.1097/gme.0b013e3181bfac3b
   KRONENBERG F, 1990, ANN NY ACAD SCI, V592, P52
   Kumari M, 2005, J CLIN EPIDEMIOL, V58, P719, DOI 10.1016/j.jclinepi.2004.09.016
   Linde K, 2007, PAIN, V128, P264, DOI 10.1016/j.pain.2006.12.006
   Melchart D, 2005, BMJ-BRIT MED J, V331, P376, DOI 10.1136/bmj.38512.405440.8F
   Nedrow A, 2006, ARCH INTERN MED, V166, P1453, DOI 10.1001/archinte.166.14.1453
   Nedstrand E, 2006, J PSYCHOSOM OBST GYN, V27, P193, DOI 10.1080/01674820600724797
   Newton KM, 1997, J WOMENS HEALTH, V6, P459, DOI 10.1089/jwh.1997.6.459
   Nir Y, 2007, MATURITAS, V56, P383, DOI 10.1016/j.maturitas.2006.11.001
   PIANSMITH MCM, 2001, ACUPUNCTURE TREATMEN, P8
   Rossouw JE, 2002, JAMA-J AM MED ASSOC, V288, P321, DOI 10.1001/jama.288.3.321
   Shumaker SA, 2003, JAMA-J AM MED ASSOC, V289, P2651, DOI 10.1001/jama.289.20.2651
   Utian Wulf H, 2005, Health Qual Life Outcomes, V3, P47, DOI 10.1186/1477-7525-3-47
   Vincent A, 2007, MENOPAUSE, V14, P45, DOI 10.1097/01.gme.0000227854.27603.7d
   Wassertheil-Smoller S, 2003, JAMA-J AM MED ASSOC, V289, P2673, DOI 10.1001/jama.289.20.2673
   Wyon Y, 2004, CLIMACTERIC, V7, P153, DOI 10.1080/13697130410001713814
   Zaborowska E, 2007, CLIMACTERIC, V10, P38, DOI 10.1080/13697130601165059
NR 37
TC 0
Z9 1
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD MAR
PY 2010
VL 17
IS 2
BP 228
EP 230
DI 10.1097/gme.0b013e3181d298e4
PG 3
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 567YN
UT WOS:000275485200003
PM 20142787
DA 2026-01-16
ER

PT J
AU Shan, YP
   Zhang, J
   Ma, YH
   Zhang, YM
AF Shan, Yunping
   Zhang, Juan
   Ma, Yinhua
   Zhang, Yiming
TI The effects of acupuncture combined with western medicine in the
   treatment of neck, shoulder, lumbar and leg pain
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Neck shoulder low back pain; acupuncture treatment; symptom improvement;
   motor functions; inflammatory factors
ID PHYSICAL-THERAPY; HERBAL MEDICINE; PRIMARY-CARE; SCALE; BACK
AB Objective: To investigate the effect of Traditional Chinese Medicine (TCM) acupuncture combined with western medicine in the treatment of neck, shoulder, lumbar and leg pain and its influence on the degree of pain, motor functions and inflammatory factor levels. Methods: In this retrospective study, 86 patients with neck, shoulder, lumbar and leg pain treated in Department of Orthopedics and Traumatology, Hangzhou Fuyang Hospital of TCM from June 2019 to June 2022 were selected as the study subjects. According to different treatment methods, these patients were divided into an observation group (n=43) and a control group (n=43). Patients from the control group were treated with conventional western medicine, while those from the observation group were treated with combination of traditional Chinese medicine acupuncture (Acupuncture + Fumigation with Collaterals-Dredging Decoction) and western medicine. Patients in both groups were treated for 4 weeks continuously. The treatment effect, visual analogue scale (VAS) score, limb motor function scale (Fugl-Meyer) score, cervical function score, daily living ability score, the levels of inflammatory factors including interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and C-reactive protein (CRP) were recorded and compared between two groups. Results: The effective rate of patients in the observation group was 93.02%, which was significantly higher than 76.74% in the control group (P<0.05). There was no significant difference in the term of Fugl-Meyer score, VAS score and levels of inflammatory factors before treatment between two groups (all P>0.05). After treatment, the VAS score and the levels of IL-6, TNF-a and CRP in both of groups significantly decreased in contrast to before treatment. The Fugl-Meyer score after treatment in both of groups was significantly increased in contrast to before treatment. Compared with those after treatment in control group, the VAS score and the levels of IL-6, TNF-a and CRP after treatment in the observation group were obviously lower, while the Fugl-Meyer score in the observation group was significantly higher (all P<0.05). Conclusion: TCM acupuncture combined with western medicine has a good therapeutic effect on neck, shoulder, lumbar and leg pains, which can effectively relieve the pain, improve motor function and reduce the inflammatory reactions in patients. The combined treatment has clinical application values and is worth promoting.
C1 [Shan, Yunping; Ma, Yinhua] Hangzhou Fuyang Hosp TCM Orthoped & Traumatol, Dept Pain Treatment, Hangzhou, Zhejiang, Peoples R China.
   [Zhang, Juan] Zhejiang Prov Hosp TCM, Dept Pain Treatment, Hangzhou, Zhejiang, Peoples R China.
   [Zhang, Yiming] Hangzhou Fuyang Hosp TCM Orthoped & Traumatol, Orthoped & Traumatol Dept, Hangzhou, Zhejiang, Peoples R China.
   [Zhang, Yiming] Hangzhou Fuyang Hosp TCM Orthoped & Traumatol, Orthoped & Traumatol Dept, 418 Fengpu Rd,Fuchun St, Hangzhou 311400, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University
RP Zhang, YM (corresponding author), Hangzhou Fuyang Hosp TCM Orthoped & Traumatol, Orthoped & Traumatol Dept, 418 Fengpu Rd,Fuchun St, Hangzhou 311400, Zhejiang, Peoples R China.
EM zhangyiming_doctor@outlook.com
CR Baroncini A, 2022, J ORTHOP SURG RES, V17, DOI 10.1186/s13018-022-03212-3
   Childs JD, 2008, J ORTHOP SPORT PHYS, V38, pA1, DOI 10.2519/jospt.2008.0303
   Dionne CE, 2022, SPINE, V47, pE595, DOI 10.1097/BRS.0000000000004408
   Dong HY, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-69382-4
   Haas R, 2023, BMC PRIM CARE, V24, DOI 10.1186/s12875-023-01976-z
   HERCZ G, 1988, AM J KIDNEY DIS, V11, P70, DOI 10.1016/S0272-6386(88)80179-3
   Huang HS, 2022, J REHABIL MED, V54, DOI 10.2340/jrm.v54.2304
   Kang SX, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000024200
   Trinh K, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004870.pub4
   Krebs EE, 2022, JAMA-J AM MED ASSOC, V328, P2307, DOI 10.1001/jama.2022.21833
   Li CX, 2020, EUR J PAIN, V24, P1653, DOI 10.1002/ejp.1617
   Lin GH, 2023, ARCH PHYS MED REHAB
   Ma T, 2006, AM J CHINESE MED, V34, P759, DOI 10.1142/S0192415X06004272
   Moulton CD, 2021, J AFFECT DISORDERS, V282, P280, DOI 10.1016/j.jad.2020.12.185
   Mu JL, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013814
   Oshima Y, 2022, GLOB SPINE J, V12, P795, DOI 10.1177/2192568220964167
   Panthi S, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1927-5
   Sabari JS, 2005, ARCH PHYS MED REHAB, V86, P1609, DOI 10.1016/j.apmr.2004.12.028
   Schäfer AGM, 2018, J MED INTERNET RES, V20, DOI 10.2196/jmir.9465
   Trinh K, 2010, SPINE, V35, P2121, DOI 10.1097/BRS.0b013e3181edfd17
   Wang CN, 2021, J PAIN RES, V14, P1611, DOI 10.2147/JPR.S311311
   [王樟连 WANG Zhanglian], 2007, [中国针灸, Chinese Acupuncture and Moxibustion], V27, P657
   Yang HY, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000024926
   Yao M, 2017, HEALTH QUAL LIFE OUT, V15, DOI 10.1186/s12955-017-0752-3
   Yuan QL, 2015, PLOS ONE, V10, DOI [10.1371/journal.pone.0117146, 10.1371/journal.pone.0119403]
   Yuan S, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019117
   Zeng WP, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000025686
   Zheng Zhi-xin, 2011, Zhong Xi Yi Jie He Xue Bao, V9, P153, DOI 10.3736/jcim20110207
NR 28
TC 4
Z9 5
U1 0
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2023
VL 15
IS 6
BP 4246
EP 4254
PG 9
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA M7OK9
UT WOS:001032073000024
PM 37434859
DA 2026-01-16
ER

PT J
AU Psutka, SP
   Veleber, S
   Siman, J
   Holt, SK
   Jannat, S
   Wright, JL
   Lin, DW
   Gore, JL
   Schade, GR
   Annen, Z
   Greenlee, H
AF Psutka, Sarah P.
   Veleber, Susan
   Siman, Jonathan
   Holt, Sarah K.
   Jannat, Samia
   Wright, Jonathan L.
   Lin, Daniel W.
   Gore, John L.
   Schade, George R.
   Annen, Zachary
   Greenlee, Heather
TI Phase 1/2 Randomized Clinical Trial of In-clinic acupuncture Prior to
   Bacillus Calmette-Guérin in Patients with High-risk Non-muscle-invasive
   Bladder Cancer
SO EUROPEAN UROLOGY ONCOLOGY
LA English
DT Article
DE Bacillus Calmette-Gu & eacute;rin; Bladder cancer; Acupuncture;
   Toxicity; Health-related quality of life
ID QUALITY-OF-LIFE; CALMETTE-GUERIN; EUROPEAN-ORGANIZATION; OVERACTIVE
   BLADDER; MAINTENANCE; MANAGEMENT; TA; T1; IMMUNOTHERAPY; VALIDATION
AB Background: Treatment-related dose-limiting dysuria and irritative bladder symptoms are common in patients receiving intravesical bacillus Calmette-Gu & eacute;rin (BCG) to treat non-muscle-invasive bladder cancer (NMIBC). Acupuncture has been shown to reduce pain and urinary urgency/frequency in other patient populations. Objective: To evaluate the feasibility, safety, and tolerability of weekly in-clinic preprocedural acupuncture among patients receiving induction BCG. Design, setting, and participants: Patients with high-risk NMIBC undergoing induction BCG were randomized 2:1 to a standardized acupuncture protocol (acupuncture) versus the standard-of-care control arm. Intervention: In-office acupuncture prior to each BCG instillation. Outcome measurements and statistical analyses: Feasibility was assessed via recruitment, retention, and intervention adherence. Acupuncture safety and tolerability were assessed via physician-reported Common Terminology Criteria for Adverse Events version 5.0 and adverse events (AEs). Secondary endpoints included BCG treatment adherence, patient-reported BCG-related toxicity, and bladder cancer-specific and generic (European Organisation for Research and Treatment of Cancer [EORTC]-QLQ-NMIBC-24 and EORTC-QLQ-NMIBC-C30) quality of life (QOL). Subjective assessments of acupuncture acceptability were performed through patient surveys. Results and limitations: A total of 43 individuals were randomized 2:1 to the acupuncture (n = 28) versus control (n = 15) group. The median age was 70.3 yr, and 76% were male. Week 7 follow-up surveys were completed by 93%; six participants withdrew early due to disease progression, refractory gross hematuria, or preference. Acupuncture was delivered successfully prior to each BCG treatment, with no acupuncture-related AEs or interruptions to induction BCG. BCG-attributed AEs were reported by 91% acupuncture and 100% control individuals, including pain (28% vs 43%, p = 0.34) and urinary symptoms (62% vs 79%, p = 0.31). Comparing acupuncture patients with controls, change in QOL over the study period demonstrated greater improvements in median urinary symptoms (9.5, interquartile range [IQR] 0.0-19.0 vs 0.0, IQR -14.3 to 7.1; p = 0.02) among patients in the acupuncture arm. Of the acupuncture patients, 96% reported that acupuncture was "very/extremely helpful,"and 91% would recommend acupuncture to other patients. Limitations include modest sample size and single-institution design. Conclusions: Acupuncture prior to induction BCG treatments is feasible and safe. In this phase 1/2 trial, improved urinary function scores were observed among patients undergoing acupuncture. Patients receiving acupuncture reported high degrees of satisfaction with treatments. Patient summary: We evaluated the safety and feasibility of delivering acupuncture in a urology clinic prior to weekly intravesical bladder cancer treatments with bacillus Calmette-Gu & eacute;rin (BCG) in a randomized controlled trial. We found that acupuncture could be delivered safely prior to weekly BCG instillations and that the use of acupuncture was associated with high patient satisfaction and a decrease in patient-reported urinary symptoms compared with usual care. (c) 2024 European Association of Urology. Published by Elsevier B.V. All rights reserved.
C1 [Psutka, Sarah P.; Holt, Sarah K.; Jannat, Samia; Wright, Jonathan L.; Lin, Daniel W.; Gore, John L.; Schade, George R.; Annen, Zachary] Univ Washington, Sch Med, Dept Urol, Seattle, WA USA.
   [Veleber, Susan; Siman, Jonathan; Greenlee, Heather] Fred Hutchinson Canc Ctr, Integrat Med Program, Div Support Care, Seattle, WA USA.
   [Veleber, Susan; Siman, Jonathan; Wright, Jonathan L.; Greenlee, Heather] Fred Hutchinson Canc Ctr, Div Publ Hlth Sci, Seattle, WA USA.
   [Siman, Jonathan; Greenlee, Heather] Univ Washington, Sch Med, Dept Med, Div Med Oncol, Seattle, WA USA.
   [Holt, Sarah K.; Greenlee, Heather] Fred Hutchinson Canc Ctr, Clin Res Div, Seattle, WA USA.
C3 University of Washington; University of Washington Seattle; Fred
   Hutchinson Cancer Center; Fred Hutchinson Cancer Center; University of
   Washington; University of Washington Seattle; Fred Hutchinson Cancer
   Center
RP Psutka, SP (corresponding author), Univ Washington, Dept Urol, 1959 NE Pacific St,Box 356158, Seattle, WA 98195 USA.
EM spsutka@uw.edu
RI ; Veleber, Susan/AAP-4033-2020
OI Psutka, Sarah/0000-0002-4207-7490; 
FU Early Phase Clinical Research Support Application, Cancer Center Support
   Grant Award [P30 CA015704-44]
FX This work was supported by Early Phase Clinical Research Support
   Application, Cancer Center Support Grant Award ID#P30 CA015704-44.
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   [Anonymous], 2010, BMJ-BRIT MED J, V340, DOI DOI 10.1136/BMJ.C332
   Blazeby JM, 2014, EUR UROL, V66, P1148, DOI 10.1016/j.eururo.2014.02.034
   Bohle A, 1996, J UROLOGY, V155, P1892, DOI 10.1016/S0022-5347(01)66040-3
   Brausi M, 2012, MINERVA UROL NEFROL, V64, P255
   Chang SS, 2017, J UROLOGY, V198, P552, DOI 10.1016/j.juro.2017.04.086
   Colombel M, 2006, J UROLOGY, V176, P935, DOI 10.1016/j.juro.2006.04.104
   de Wall LL, 2017, RES REP UROL, V9, P145, DOI 10.2147/RRU.S124981
   Deadman P., 1999, A Manual of Acupuncture
   Decaestecker K, 2015, RES REP UROL, V7, P157, DOI 10.2147/RRU.S63448
   Forde JC, 2016, INT UROGYNECOL J, V27, P1645, DOI 10.1007/s00192-015-2935-y
   Gan TJ, 2020, ANESTH ANALG, V131, P411, DOI 10.1213/ANE.0000000000004833
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Hershman DL, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.41720
   Johnson MH, 2013, J UROLOGY, V189, P1268, DOI 10.1016/j.juro.2012.10.070
   Koch GE, 2021, UROLOGY, V149, P11, DOI 10.1016/j.urology.2020.10.039
   Lamm DL, 2000, J UROLOGY, V163, P1124, DOI 10.1016/S0022-5347(05)67707-5
   Lao Lixing, 2006, J Soc Integr Oncol, V4, P13
   Lee JJ, 2023, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.985288
   Liao YX, 2023, INT UROL NEPHROL, V55, P489, DOI 10.1007/s11255-022-03434-8
   Lin ZX, 2020, CHIN MED-UK, V15, DOI 10.1186/s13020-020-00388-w
   Liu YH, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/2504021
   Mak TC, 2019, ACUPUNCT MED, V37, P321, DOI 10.1136/acupmed-2017-011528
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mao JJ, 2010, ALTERN THER HEALTH M, V16, P22
   Melchart D, 2004, ARCH INTERN MED, V164, P104, DOI 10.1001/archinte.164.1.104
   National AF, 2003, Clean needle technique manual for acupuncturists: guidelines and standards for the clean and safe clinical practice of acupuncture, V5
   National Cancer Institute, 2017, Common Terminology Criteria for Adverse Events (CTCAE) version 5.0
   Nelson EA, 2013, COMPLEMENT THER MED, V21, P697, DOI 10.1016/j.ctim.2013.08.020
   Oddens J, 2013, EUR UROL, V63, P462, DOI 10.1016/j.eururo.2012.10.039
   Pareek T, 2022, UROL INT, V106, P784, DOI 10.1159/000524098
   Park T, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/3759069
   Poletajew S, 2019, ANTI-CANCER DRUG, V30, P517, DOI 10.1097/CAD.0000000000000775
   Psutka SP, 2022, CONT CLIN TRIAL COMM, V30, DOI 10.1016/j.conctc.2022.101044
   Qin QG, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0781-6
   Siracusano S, 2018, CAN J UROL, V25, P9480
   Sönmez MG, 2017, GINEKOL POL, V88, P61, DOI 10.5603/GP.a2017.0013
   Sylvester RJ, 2003, EUR UROL, V44, P423, DOI 10.1016/S0302-2838(03)00371-3
   van der Meijden APM, 2003, EUR UROL, V44, P429, DOI 10.1016/S0302-2838(03)00357-9
   van Straten CGJI, 2023, EUR UROL OPEN SCI, V56, P15, DOI 10.1016/j.euros.2023.08.004
   Vegt PDJ, 1997, J UROLOGY, V157, P1246, DOI 10.1016/S0022-5347(01)64936-X
   Wang H, 2023, INT J GEN MED, V16, P1137, DOI 10.2147/IJGM.S406194
   Wu MS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150367
   Yuen JW, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191710825
   Zhao YW, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000009838
NR 45
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2588-9311
J9 EUR UROL ONCOL
JI Eur. Urol. Oncol.
PD DEC
PY 2024
VL 7
IS 6
BP 1431
EP 1440
DI 10.1016/j.euo.2024.04.002
PG 10
WC Oncology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Urology & Nephrology
GA O8S8Y
UT WOS:001373769300001
PM 38653622
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Li, H
   Shang, XJ
   Dong, QR
AF Li, Huan
   Shang, Xiao-Jun
   Dong, Qi-Rong
TI Effects of transcutaneous electrical nerve stimulation on rats with the
   third lumbar vertebrae transverse process syndrome
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
ID PAIN; MODEL; FREQUENCY; INFLAMMATION; SUPPRESSION; RECEPTOR; THERAPY
AB Objective To investigate the analgesic and anti-inflammatory effects of transcutaneous electrical nerve stimulation (TENS) at local or distant acupuncture points in a rat model of the third lumbar vertebrae transverse process syndrome.
   Methods Forty Sprague-Dawley rats were randomly divided into control, model, model plus local acupuncture point stimulation at BL23 (model+LAS) and model plus distant acupuncture point stimulation at ST36 (model+DAS) groups. All rats except controls underwent surgical third lumbar vertebrae transverse process syndrome modelling on day 2. Thereafter, rats in the model+LAS and model+DAS groups were treated daily with TENS for a total of six treatments (2/100 Hz, 30 min/day) from day 16 to day 29. Thermal pain thresholds were measured once a week during treatment and were continued until day 57, when local muscle tissue was sampled for RTPCR and histopathological examination after haematoxylin and eosin staining. mRNA expression of interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) was determined.
   Results Thermal pain thresholds of all model rats decreased relative to the control group. Both LAS and DAS significantly increased the thermal pain threshold at all but one point during the treatment period. Histopathological assessment revealed that the local muscle tissues around the third lumbar vertebrae transverse process recovered to some degree in both the model+LAS and model+DAS groups; however, LAS appeared to have a greater effect. mRNA expression of IL-1 beta, TNF-alpha and iNOS in the local muscle tissues was increased after modelling and attenuated in both model+LAS and model+DAS groups. The beneficial effect was greater after LAS than after DAS.
   Conclusions TENS at both local (BL23) and distant (ST36) acupuncture points had a pain-relieving effect in rats with the third lumbar vertebrae transverse process syndrome, and LAS appeared to have greater anti-inflammatory and analgesic effects than DAS.
C1 [Li, Huan; Dong, Qi-Rong] Suzhou Univ, Affiliated Hosp 2, Dept Orthopaed, Suzhou, Jiangsu, Peoples R China.
   [Li, Huan; Shang, Xiao-Jun] Suzhou Univ, Peoples Hosp Changzhou 1, Dept Orthopaed, Suzhou, Jiangsu, Peoples R China.
   [Li, Huan; Shang, Xiao-Jun] Suzhou Univ, Affiliated Hosp 3, Suzhou, Jiangsu, Peoples R China.
RP Dong, QR (corresponding author), Suzhou Univ, Affiliated Hosp 2, Dept Orthopaed, 1005 Sanxiang Rd, Suzhou, Jiangsu, Peoples R China.
EM qrdong0512@126.com
CR Alves DP, 2013, NITRIC OXIDE-BIOL CH, V28, P8, DOI 10.1016/j.niox.2012.09.001
   Bo L, 2013, J ACUPUNCT TUINA SCI, V2, P113
   Maciel LYD, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/485043
   Gao YH, 2013, NEUROCHEM RES, V38, P1467, DOI 10.1007/s11064-013-1047-7
   Gim GT, 2011, BRAIN RES BULL, V86, P403, DOI 10.1016/j.brainresbull.2011.09.010
   Gonçalves DO, 2011, BRAZ J MED BIOL RES, V44, P173, DOI 10.1590/S0100-879X2011007500001
   Guo Chang-Qing, 2012, Zhongguo Zhen Jiu, V32, P617
   Guo CQ, 2014, J TRADIT CHIN MED, V34, P194, DOI 10.1016/S0254-6272(14)60078-9
   Kim HW, 2008, BRAIN RES BULL, V75, P698, DOI 10.1016/j.brainresbull.2007.11.015
   LaBuda CJ, 2006, EUR J PAIN, V10, P505, DOI 10.1016/j.ejpain.2005.07.004
   Li C, 2011, J ACUPUNCT TUINA SCI, V9, P73
   Li HY, 2010, ALTERN THER HEALTH M, V16, P38
   Lima LV, 2015, EUR J PAIN, V19, P369, DOI 10.1002/ejp.555
   Noma N, 2013, J DENT RES, V92, P456, DOI 10.1177/0022034513483770
   Özaktay AC, 2002, EUR SPINE J, V11, P467, DOI 10.1007/s00586-002-0430-x
   Park C, 2015, ANAESTHESIA, V70, P434, DOI 10.1111/anae.12933
   Qiao JL, 2011, J TRADIT CHIN MED, V31, P83, DOI 10.1016/S0254-6272(11)60018-6
   Shih CM, 2009, ANESTH ANALG, V108, P1303, DOI 10.1213/ane.0b013e318193e919
   Sun Chang-le, 2011, Zhongguo Gu Shang, V24, P828
   Takahashi H, 1996, SPINE, V21, P218, DOI 10.1097/00007632-199601150-00011
   Tucker DL, 2015, J CLIN PATHOL, V68, P479, DOI 10.1136/jclinpath-2015-202908
   Vallinga MS, 2015, J SEX MED, V12, P228, DOI 10.1111/jsm.12740
   [王健瑞 Wang Jianrui], 2003, [中华物理医学与康复杂志, Chinese Journal of Physical Medicine and Rehabilitation], V25, P394
   Wang S, 1999, J Tradit Chin Med, V19, P190
   Wang Yong-zhi, 2009, Zhongguo Gu Shang, V22, P438
   Wen You-Liang, 2012, Zhongguo Zhen Jiu, V32, P345
   Xiang XH, 2014, J NEUROSCI RES, V92, P555, DOI 10.1002/jnr.23351
   Yamazaki H, 2014, J ORTHOP RES, V32, P286, DOI 10.1002/jor.22486
   Zeng C, 2015, OSTEOARTHR CARTILAGE, V23, P189, DOI 10.1016/j.joca.2014.11.014
NR 29
TC 8
Z9 10
U1 1
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD OCT
PY 2015
VL 33
IS 5
BP 400
EP 405
DI 10.1136/acupmed-2014-010752
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CW4XM
UT WOS:000364999900010
PM 26104377
DA 2026-01-16
ER

PT J
AU Romeo, MJ
   Parton, B
   Russo, RA
   Hays, LS
   Conboy, L
AF Romeo, Melissa J.
   Parton, Barbara
   Russo, Rachel A.
   Hays, Lewis S.
   Conboy, Lisa
TI ACUPUNCTURE TO TREAT THE SYMPTOMS OF PATIENTS IN A PALLIATIVE CARE
   SETTING
SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
LA English
DT Article
DE palliative; hospice; acupuncture; pain; well-being; anxiety
ID CANCER; COMPLEMENTARY; PAIN; MANAGEMENT; MEDICINE; DYSPNEA; RELIEF;
   NAUSEA; LIFE
AB Introduction: Patients enrolled in hospice and palliative care programs experience a vast array of symptoms requiring the expertise of a multidisciplinary team to address. Acupuncture can be an effective addition to a hospice team whose goal is maximum comfort and quality of life (QOL). The objective of this project was to examine the effectiveness of acupuncture to relieve symptoms commonly observed in patients in a hospice program.
   Methods: All over 26 patients participated in the acupuncture trial, receiving a course of weekly treatments that ranged from 1 to 14 weeks. The average number of treatments was five. The Edmonton Symptom Assessment Scale (ESAS) was used to assess the severity of pain, tiredness, nausea, depression, anxiety, drowsiness, appetite, well-being, and dyspnea. A two-tailed, paired t test was applied to the data to compare symptom scores pre- versus post-acupuncture treatment.
   Settings/Participants: Patients enrolled in All Care Hospice's home care program were given the option to receive acupuncture to supplement usual care offered by the hospice team. Treatment was provided by licensed acupuncturists in the patient's place of residence.
   Results: Seven out of nine symptoms were significantly (P < .001) improved with acupuncture, the exceptions being drowsiness and appetite. Although the ESAS scale demonstrated a reduction in symptom severity post-treatment for both drowsiness and appetite, this reduction was not found to be significant.
   Conclusion: Acupuncture was found to be effective for the reduction and relief of symptoms that commonly affect patient QOL. Acupuncture effectively reduced symptoms of pain, tiredness, nausea, depression, anxiety, and shortness of breath, and enhanced feelings of well-being. More research is required to assess the long-term benefits and symptom reduction of acupuncture in a palliative care setting.
C1 [Romeo, Melissa J.; Parton, Barbara; Conboy, Lisa] New England Sch Acupuncture, Newton, MA 02458 USA.
   [Parton, Barbara; Russo, Rachel A.; Hays, Lewis S.] All Care Hosp, Lynn, MA USA.
   [Parton, Barbara] Tufts Med Ctr, Boston, MA USA.
   [Hays, Lewis S.] Tufts Univ, Sch Med, Boston, MA 02111 USA.
   [Conboy, Lisa] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
C3 Tufts Medical Center; Tufts University; Harvard University; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center
RP Romeo, MJ (corresponding author), New England Sch Acupuncture, 150 Calif St, Newton, MA 02458 USA.
EM mromeo@nesa.edu
RI Conboy, Lisa/ABC-5173-2021
CR Abernethy Amy P, 2008, J Pain Palliat Care Pharmacother, V22, P145
   Ben-Aharon I, 2008, J CLIN ONCOL, V26, P2396, DOI 10.1200/JCO.2007.15.5796
   Centers for Medicare and Medicaid Services (CMS), 2008, MED MED PROGR HOSP C, V73, P120
   Chang BH, 2010, J SUBST USE, V15, P390, DOI 10.3109/14659890903580466
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Dillon M, 1999, PALLIATIVE MED, V13, P253, DOI 10.1191/026921699667999073
   Faily J, 2007, SUPPORT CARE CANCER, V15, P1003, DOI 10.1007/s00520-007-0294-z
   Filshie J, 2001, Acupunct Med, V19, P117
   Filshie J, 1996, PALLIATIVE MED, V10, P145, DOI 10.1177/026921639601000209
   Filshie Jacqueline, 2006, Acupunct Med, V24, P172
   Filshie J, 2011, ACUPUNCT MED, V29, P166, DOI 10.1136/acupmed-2011-010063
   Johnstone PAS, 2002, PALLIATIVE MED, V16, P235, DOI 10.1191/0269216302pm540oa
   Lee H, 2005, EUR J PAIN, V9, P437, DOI 10.1016/j.ejpain.2004.10.004
   Leng G, 1999, PALLIATIVE MED, V13, P163, DOI 10.1191/026921699676243035
   Lewith GT, 2004, CHEST, V125, P1783, DOI 10.1378/chest.125.5.1783
   Lim JTW, 2011, ACUPUNCT MED, V29, P173, DOI 10.1136/aim.2011.004044
   Mansky PJ, 2006, CANCER J, V12, P425, DOI 10.1097/00130404-200609000-00011
   Nystrom E, 2008, ACUPUNCT MED, V26, P27, DOI 10.1136/aim.26.1.27
   Pan CX, 2000, J PAIN SYMPTOM MANAG, V20, P374, DOI 10.1016/S0885-3924(00)00190-1
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Schulman-Green D, 2010, J PALLIAT MED, V13, P155, DOI 10.1089/jpm.2009.0245
   Sellick S M, 1998, Cancer Prev Control, V2, P7
   Spiller Juliet, 2007, Acupunct Med, V25, P109
   Standish LJ, 2008, AM J HOSP PALLIAT ME, V25, P298, DOI 10.1177/1049909108315916
   Vickers Andrew J, 2005, BMC Palliat Care, V4, P5, DOI 10.1186/1472-684X-4-5
   Zappa SB, 2003, J NURS CARE QUAL, V18, P22, DOI 10.1097/00001786-200301000-00004
NR 27
TC 14
Z9 20
U1 0
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-8307
EI 1878-7541
J9 EXPLORE-NY
JI Explore-J Sci. Heal.
PD SEP-OCT
PY 2015
VL 11
IS 5
BP 357
EP 362
DI 10.1016/j.explore.2015.06.001
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CQ7JT
UT WOS:000360780500004
PM 26254221
DA 2026-01-16
ER

PT J
AU Du, SS
   Yang, T
   Qiang, S
   Lin, Z
AF Shanshan, Du
   Yang, Tingting
   Qiang, Sun
   Lin, Zhang
TI RETRACTED: Molecular mechanism of electroacupuncture treatment on
   oxaliplatin-induced peripheral neurotoxicity in rats (Retracted article.
   See vol. 21, 2023)
SO EUROPEAN JOURNAL OF INFLAMMATION
LA English
DT Article; Retracted Publication
DE electroacupuncture; molecular mechanism; oxaliplatin; peripheral
   neurotoxicity
ID METASTATIC COLORECTAL-CANCER; EXPRESSION; NEUROPATHY; COLD; PROTEINS;
   PAIN
AB Oxaliplatin (L-OHP) has been widely used in the treatment of various tumors, especially in colorectal cancer. The mechanism of peripheral neurotoxicity induced by L-OHP (OIPN) is unclear and current therapeutic options only serve to alleviate the symptoms rather than prevent OIPN. To observe the effects of electroacupuncture (EA) stimulation on OIPN in rats, rats were randomly divided into the control group, OIPN model group, and OIPN + EA group. To establish OIPN rat models, a single intraperitoneal injection with 10 mg/kg L-OHP in the OIPN model rats. Rats in the control group received a single intraperitoneal injection with 0.9% lactose. From the third day after establishing OIPN models, the rats were treated with EA. Cold allodynia and heat sensitivity were assessed using the acetone drop and the Hargreaves method, respectively. Pathological changes in nerves were detected using hematoxylin and eosin (H&E) staining and transmission electron microscopy. Related mRNA and protein expression levels were measured by real-time polymerase chain reaction (PCR) and western blotting from 14 days after establishing OIPN models. Our results showed that L-OHP significantly increased the sensitivity to cold allodynia and nervous injury, which were ameliorated after EA treatment. The expression of glucocorticoid receptor alpha (GR-alpha) and B-cell lymphoma 2 (Bcl-2) was significantly decreased and that of Bax was significantly increased in sciatic nerve of OIPN model rats compared with control rats. However, EA treatment significantly inhibited L-OHP-induced protein expressions in rats. Moreover, compared with the control rats, the nucleus NF-kappa Bp65 levels were significantly increased, while the cytoplasm NF-kappa Bp65 levels were significantly decreased, which were reversed by EA treatment. In conclusion, EA treatment may reduce peripheral neurotoxicity induced by L-OHP through regulating related protein expression.
C1 [Shanshan, Du; Yang, Tingting; Lin, Zhang] Community Hlth Serv Ctr Minhang Dist, Dept Acupuncture & Traumatol, Shanghai, Peoples R China.
   [Qiang, Sun] Changzheng Hosp, Dept Gen Surg, Shanghai, Peoples R China.
C3 Naval Medical University
RP Lin, Z (corresponding author), Gumei Community Hlth Serv Ctr Minhang Dist, Dept Acupuncture & Traumatol, Shanghai 201102, Peoples R China.
EM skhmiv7529651@163.com
RI du, shanshan/AAE-7491-2022
CR Areti A, 2014, REDOX BIOL, V2, P289, DOI 10.1016/j.redox.2014.01.006
   de Sena LSB, 2018, J ORAL PATHOL MED, V47, P788, DOI 10.1111/jop.12757
   Cavaletti G, 2002, ANTICANCER RES, V22, P4199
   Choi JW, 2015, AM J CHINESE MED, V43, P57, DOI 10.1142/S0192415X15500044
   Flatters SJL, 2004, PAIN, V109, P150, DOI 10.1016/j.pain.2004.01.029
   Hecht JR, 2015, CANCER MANAG RES, V7, P165, DOI 10.2147/CMAR.S61408
   Ihara K, 2016, ONCOL REP, V35, P1349, DOI 10.3892/or.2015.4488
   Jin Ze, 2011, Zhongguo Zhen Jiu, V31, P613
   Kelly H, 2005, J CLIN ONCOL, V23, P4553, DOI 10.1200/JCO.2005.17.749
   Kim JH, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-254
   Kolb NA, 2016, JAMA NEUROL, V73, P860, DOI 10.1001/jamaneurol.2016.0383
   Li Q, 2014, EVID-BASED COMPL ALT, V2014, DOI DOI 10.1155/2014/158987
   Li QW, 2007, J ACUPUNCT TUINA SCI, V5, P10
   Manni L, 2011, DIABETOLOGIA, V54, P1900, DOI 10.1007/s00125-011-2117-5
   McKeage MJ, 2001, BRIT J CANCER, V85, P1219, DOI 10.1054/bjoc.2001.2024
   Moon HJ, 2014, J PHYSIOL SCI, V64, P151, DOI 10.1007/s12576-013-0297-0
   Ogawa K, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/928129
   Park JH, 2010, BRAIN RES, V1322, P24, DOI 10.1016/j.brainres.2010.02.001
   Park SB, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018469
   Pereira V, 2014, PAIN, V155, P2534, DOI 10.1016/j.pain.2014.09.013
   Prenek L, 2017, APOPTOSIS, V22, P239, DOI 10.1007/s10495-016-1320-8
   Schulze C, 2011, CLIN COLORECTAL CANC, V10, P126, DOI 10.1016/j.clcc.2011.03.010
   Shao JP, 2018, LIFE SCI, V208, P268, DOI 10.1016/j.lfs.2018.07.026
   Sun XJ, 2018, LIFE SCI, V195, P33, DOI 10.1016/j.lfs.2018.01.006
   Tsutsumi K, 2014, NEUROSCI RES, V80, P86, DOI 10.1016/j.neures.2014.02.004
   Ursic K, 2018, BIOELECTROCHEMISTRY, V119, P161, DOI 10.1016/j.bioelechem.2017.09.009
   Waseem M, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180953
   Xiao WH, 2012, NEUROSCIENCE, V203, P194, DOI 10.1016/j.neuroscience.2011.12.023
   Yerra VG, 2013, REDOX BIOL, V1, P394, DOI 10.1016/j.redox.2013.07.005
   Zhao W, 2008, NEUROCHEM RES, V33, P2214, DOI 10.1007/s11064-008-9677-x
   Zheng HE, 2011, EXP NEUROL, V232, P154, DOI 10.1016/j.expneurol.2011.08.016
NR 31
TC 1
Z9 1
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1721-727X
EI 2058-7392
J9 EUR J INFLAMM
JI Eur. J. Inflamm.
PD OCT
PY 2020
VL 18
AR 2058739220929149
DI 10.1177/2058739220929149
PG 10
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA OG9PY
UT WOS:000582207900001
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, HJ
   Wang, B
   Chen, CY
AF Li, Hanjing
   Wang, Biao
   Chen, Chuanyuan
TI Acupuncture around the greater tuberosity of the femur combined with
   acupuncture at Xuehai acupoint alleviates the postoperative pain of
   elderly patients with intertrochanteric fracture
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Greater tuberosity of the femur; Xuehai acupoint; intertrochanteric
   fracture; pain
ID HIP; MANAGEMENT
AB Objective: To determine the efficacy of acupuncture around the greater tuberosity of the femur (AGTF) combined with acupuncture at Xuehai acupoint for postoperative pain in elderly patients with intertrochanteric fracture. Methods: A total of 97 elderly patients with intertrochanteric fracture treated by proximal femoral nail antirotation (PFNA) were enrolled and randomly assigned into an observation group (Obs group, n=48) and a control group (Con group, n=49). The Obs group was treated by aspirin and AGTF combined with acupuncture at Xuehai acupoint for analgesia, while the Con group was treated by aspirin alone for analgesia. Both groups were treated for 7 consecutive days. The two groups were compared in pain degree (visual analog scale (VAS) score) after operation and hip joint function (Harris score), daily living ability (modified Barthel index (MBI) score), bone metabolism-related indexes, and inflammatory factors before and after treatment. Results: At 1-7 d after operation, both groups had gradually lower VAS scores, and at 5 and 7 d after operation, the Obs group had a lower VAS score than the Con group (both P<0.05). Additionally, at 2 months after operation, both groups had higher Harris scores and MBI scores, and the scores of the Obs group were both higher than those of the Con group (both P<0.05). At 7 d after operation, both groups showed a decrease in serum beta collagen degradation products (beta-CTx) and an increase in procollagen type I amino-terminal propeptide (PINP) (both P<0.05), but the differences between the two groups in beta-CTx and PINP were insignificant (P>0.05). Moreover, at 7 d after operation, both groups showed a decrease in C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-alpha), and the two levels in the Obs group were lower than those in the Con group (both P<0.05). Conclusion: For elderly patients with intertrochanteric fracture, AGTF combined with acupuncture at the Xuehai acupoint can more effectively relieve their postoperative pain and postoperative inflammation and more strongly promote their postoperative recovery of hip joint function.
C1 [Li, Hanjing] Xiamen Univ, Fuzhou Hosp Affiliated 2, Dept Tradit Chinese Med, Fuzhou, Fujian, Peoples R China.
   [Wang, Biao; Chen, Chuanyuan] Xiamen Univ, Fuzhou Hosp Affiliated 2, Dept Orthoped, 47 Shangteng Rd, Fuzhou 350007, Fujian, Peoples R China.
C3 Xiamen University; Xiamen University
RP Chen, CY (corresponding author), Xiamen Univ, Fuzhou Hosp Affiliated 2, Dept Orthoped, 47 Shangteng Rd, Fuzhou 350007, Fujian, Peoples R China.
EM chenchuanyuan118@163.com
CR Audigé L, 2017, ACTA ORTHOP, V88, P133, DOI 10.1080/17453674.2016.1258534
   Cavalier E, 2019, CLIN CHEM LAB MED, V57, P1546, DOI 10.1515/cclm-2019-0174
   Gaffney CJ, 2017, ORTHOP CLIN N AM, V48, P407, DOI 10.1016/j.ocl.2017.05.001
   Hoffmann MF, 2019, J ORTHOP SURG RES, V14, DOI 10.1186/s13018-019-1431-3
   Horwitz DS, 2016, J AM ACAD ORTHOP SUR, V24, pE50, DOI 10.5435/JAAOS-D-15-00325
   Jia Chengjie, 2015, Zhongguo Zhen Jiu, V35, P1131
   Kalinichenko LS, 2019, FRONT NEUROENDOCRIN, V55, DOI 10.1016/j.yfrne.2019.100783
   Karakus O, 2018, J ORTHOP SURG RES, V13, DOI 10.1186/s13018-018-0911-1
   Lisowska B, 2018, DRUG DES DEV THER, V12, P1809, DOI 10.2147/DDDT.S164565
   Liu F, 2020, J STROKE CEREBROVASC, V29, DOI 10.1016/j.jstrokecerebrovasdis.2020.105033
   Liu LY, 2019, EUR J MED RES, V24, DOI 10.1186/s40001-019-0398-1
   Marsland AL, 2017, BRAIN BEHAV IMMUN, V64, P208, DOI 10.1016/j.bbi.2017.01.011
   Medda S, 2019, J ORTHOP TRAUMA, V33, P341, DOI 10.1097/BOT.0000000000001442
   Mimouni M, 2019, CURR EYE RES, V44, P790, DOI 10.1080/02713683.2019.1589524
   Kien NT, 2019, DRUG DES DEV THER, V13, P2145, DOI 10.2147/DDDT.S202410
   Orchard T, 2017, J BONE MINER RES, V32, P1136, DOI 10.1002/jbmr.3070
   Sahin M, 2016, TURK J MED SCI, V46, P265, DOI 10.3906/sag-1409-66
   Socci AR, 2017, BONE JOINT J, V99B, P128, DOI 10.1302/0301-620X.99B1.BJJ-2016-0134.R1
   Wang Yu-Chen, 2019, Zhongguo Gu Shang, V32, P837, DOI 10.3969/j.issn.1003-0034.2019.09.013
   Weel H, 2017, ACTA ORTHOP BELG, V83, P98
   Xiao Qiang, 2019, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V33, P1190, DOI 10.7507/1002-1892.201903026
   Xu LL, 2018, J CANCER RES THER, V14, P99, DOI 10.4103/jcrt.JCRT_736_17
   Yao Min, 2019, Zhongguo Zhen Jiu, V39, P1181, DOI 10.13703/j.0255-2930.2019.11.012
   Yilmaz S, 2020, J TRADIT CHIN MED, V40, P275
   Zhang Malan, 2018, Zhongguo Zhen Jiu, V38, P591, DOI 10.13703/j.0255-2930.2018.06.006
   Zulauf N, 2019, ONCOLOGY-BASEL, V97, P236, DOI 10.1159/000500675
NR 26
TC 11
Z9 14
U1 0
U2 13
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2021
VL 13
IS 7
BP 8372
EP 8378
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA TT0LI
UT WOS:000680042800085
PM 34377330
DA 2026-01-16
ER

PT J
AU Jin, M
   Xie, LL
   Mao, N
   Wei, JZ
   Chen, JC
   Chen, XF
   Mao, HJ
AF Jin, Ming
   Xie, Lulu
   Mao, Ni
   Wei, Jianzi
   Chen, Junchao
   Chen, Xuefen
   Mao, Huijuan
TI The characteristics of registered acupuncture clinical trials enrolling
   cancer patients
SO SUPPORTIVE CARE IN CANCER
LA English
DT Review
DE Acupuncture; Clinical trial registration; Cancer; Cancer-related
   symptoms
ID INTERNATIONAL COMMITTEE
AB Purpose This study sought to explore and summarize the global state of acupuncture clinical trials enrolling cancer patients included in international registries to date.
   Methods All relevant trials evaluating acupuncture-related interventions for the treatment of cancer that were registered in 16 trial registries from January 1, 2001, through December 31, 2020, were identified. Subsequent publications related to these trials were additionally retrieved from the PubMed, Cochrane Library, Embase, CNKI (China National Knowledge Infrastructure), VIP (China Science and Technology Journal Database), and Wanfang databases. We compared information included in these registries regarding completed trials with any associated publications, with a focus on study design, sample size, and selective reporting, based on the registered protocol.
   Results In total, 222 eligible trials across 19 countries were identified. These trials included 17 specific cancer types and 32 symptoms. The five most common cancer types were breast cancer, head and neck cancer, colorectal cancer, lung cancer, and gastric cancer, accounting for almost half of all registered trials (48.2%). The top five symptoms included in these trials were chemotherapy-induced peripheral neuropathy (CIPN), cancer-related pain, cancer-related fatigue, chemotherapy-induced nausea and vomiting (CINV), and gastrointestinal dysfunction. The overall rate of article publication was low, with publications being associated with just 33.3% of these registered trials.
   Conclusions This review is the first snapshot of the landscape of acupuncture clinical trials registered in international trial registries, providing a methodological basis for the management of common treatment- and disease-related side effects among cancer patients undergoing acupuncture and offering useful information that will guide future acupuncture-focused research.
C1 [Jin, Ming] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Shanghai 200437, Peoples R China.
   [Xie, Lulu; Mao, Ni; Wei, Jianzi; Mao, Huijuan] Shanghai Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Shanghai 201203, Peoples R China.
   [Chen, Junchao] Shanghai Univ Tradit Chinese Med, Inst Disciplinary Sci, Shanghai 201203, Peoples R China.
   [Chen, Xuefen] Shanghai Univ Tradit Chinese Med, Sch Publ Hlth, Shanghai 201203, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Shanghai University of Traditional
   Chinese Medicine; Shanghai University of Traditional Chinese Medicine
RP Mao, HJ (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Shanghai 201203, Peoples R China.; Chen, XF (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Publ Hlth, Shanghai 201203, Peoples R China.
EM jinming80266@163.com; xielulu920@163.com; mn13887454832@163.com;
   weijz2000@126.com; junchaochen@live.cn; chenxf915@163.com;
   maohuijuan1977@hotmail.com
FU National Natural Science Foundation of Shanghai [21ZR1463300]
FX This research is funded in part by grants from the National Natural
   Science Foundation of Shanghai (21ZR1463300).
CR [Anonymous], Acupuncture: An Introduction
   Bian ZX, 2010, TRIALS, V11, DOI 10.1186/1745-6215-11-64
   Birch S, 2019, INTEGR MED RES, V8, P160, DOI 10.1016/j.imr.2019.05.002
   Chan AW, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.e7586
   Chen JC, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/9461415
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   De Angelis CD, 2005, NEW ENGL J MED, V352, P2436, DOI 10.1056/NEJMe058127
   drjohnbarrett, WP CONTENT UPLOADS
   Fanaroff AC, 2019, LANCET, V394, P633, DOI 10.1016/S0140-6736(19)31256-5
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hou WZ, 2019, J OBSTET GYNAECOL RE, V45, P2307, DOI 10.1111/jog.14122
   Huser V, 2013, J AM MED INFORM ASSN, V20, pE169, DOI 10.1136/amiajnl-2012-001501
   Jang A, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420949679
   Kunath F, 2011, BMJ OPEN, V1, DOI 10.1136/bmjopen-2011-000430
   Lin XF, 2016, J BONE JOINT SURG AM, V98, P1578, DOI 10.2106/JBJS.15.00620
   Liu JP, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2013-002968
   Schulz KF, 2010, EPIDEMIOL BIOSTAT PU, V7, P325
   SIMES RJ, 1986, J CLIN ONCOL, V4, P1529, DOI 10.1200/JCO.1986.4.10.1529
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Viergever RF, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008932
   Yu He, 2007, Zhong Xi Yi Jie He Xue Bao, V5, P234
   Zarin DA, 2015, NEW ENGL J MED, V372, P174, DOI 10.1056/NEJMsr1414226
   Zhang YQ, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj-2021-067476
   Zhao Jingsheng, 2017, Zhongguo Zhen Jiu, V37, P1115, DOI 10.13703/j.0255-2930.2017.10.024
NR 24
TC 6
Z9 6
U1 1
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD DEC
PY 2022
VL 30
IS 12
BP 10461
EP 10470
DI 10.1007/s00520-022-07331-9
EA SEP 2022
PG 10
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 8M5WY
UT WOS:000849310000002
PM 36048280
DA 2026-01-16
ER

PT J
AU Xue, Y
   Dai, SL
   Liang, JX
   Ji, WJ
AF Xue, Yan
   Dai, Sailin
   Liang, Jiexian
   Ji, Wenjin
TI Effect of reactive oxygen species of the psoas major muscle in complete
   Freund's adjuvant-induced inflammatory pain in rats
SO MOLECULAR PAIN
LA English
DT Article
DE Lower limb pain; psoas major muscle; reactive oxygen species; PBN;
   complete Freund's adjuvant-induced inflammatory pain
ID INDUCED MECHANICAL HYPERALGESIA; FREE-RADICALS; OXIDATIVE STRESS;
   NEUROPATHIC PAIN; ALLODYNIA; MODEL; SUPEROXIDE; ROS; ANTIOXIDANTS;
   SCAVENGER
AB Lower limb pain is a common clinical disease that affects millions of people worldwide. It is found in previous studies that reactive oxygen species is closely related to neuropathic, cancer, chemotherapy, and inflammatory pain, which can be relieved by reactive oxygen species scavengers. Furthermore, acupuncture or electroacupuncture on the psoas major muscle has a great effect on adjuvant-induced arthritis and lower back pain. In our study, we investigated the function of reactive oxygen species scavengers locally injecting into the ipsilateral psoas major muscle on complete Freund's adjuvant-induced inflammatory pain. Our results demonstrated that in the development of complete Freund's adjuvant-induced inflammatory pain, early local continuous application of N-tert-Butyl-alpha-phenylnitrone (PBN, 1 and 5 mg/kg/0.2 ml) on the ipsilateral psoas major muscle effectively reduced mechanical and cold hyperalgesia. However, intraperitoneal injection of PBN (1 and 5 mg/kg) or local injection of PBN (1 and 5 mg/kg/0.2 ml) into contralateral psoas major muscle, ipsilateral quadratus lumborum, and ipsilateral erector spinae showed limited effect. In the developed inflammatory pain model, local injection of PBN into the ipsilateral psoas major muscle also alleviated pain and paw edema. In addition, reactive oxygen species level increased in ipsilateral psoas major muscle at seven days after complete Freund's adjuvant injection. In general, PBN reduces complete Freund's adjuvant-evoked inflammatory pain by inhibiting reactive oxygen species in the psoas major muscle.
C1 [Xue, Yan; Liang, Jiexian] South China Univ Technol, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci,Div Anesthesiol, Sch Med,Dept Cardiovasc Surg,Guangdong Inst Cardi, 96 DongChun Rd, Guangzhou 510080, Guangdong, Peoples R China.
   [Xue, Yan; Liang, Jiexian; Ji, Wenjin] Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Anesthesiol, Guangzhou, Peoples R China.
   [Dai, Sailin] Fudan Univ, Shanghai Canc Ctr, Dept Anesthesiol, Shanghai, Peoples R China.
C3 Guangdong Academy of Medical Sciences & Guangdong General Hospital;
   South China University of Technology; Southern Medical University -
   China; Southern Medical University - China; Guangdong Academy of Medical
   Sciences & Guangdong General Hospital; Fudan University
RP Liang, JX (corresponding author), South China Univ Technol, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci,Div Anesthesiol, Sch Med,Dept Cardiovasc Surg,Guangdong Inst Cardi, 96 DongChun Rd, Guangzhou 510080, Guangdong, Peoples R China.
EM lijessy@msn.com
FU National Natural Science Foundation of China [81171040, 81371236]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by grants from the National Natural Science Foundation of
   China (grant numbers 81171040 and 81371236).
CR Almarestani L, 2011, ARTHRITIS RHEUM-US, V63, P1573, DOI 10.1002/art.30303
   Almarestani L, 2008, MOL PAIN, V4, DOI 10.1186/1744-8069-4-56
   Arbanas J, 2013, EUR SPINE J, V22, P1965, DOI 10.1007/s00586-013-2749-x
   Areti A, 2014, REDOX BIOL, V2, P289, DOI 10.1016/j.redox.2014.01.006
   Walker CIB, 2017, N-S ARCH PHARMACOL, V390, P1163, DOI 10.1007/s00210-017-1416-x
   Boettger MK, 2007, EUR J PAIN, V11, P810, DOI 10.1016/j.ejpain.2006.12.008
   CHAPLAN SR, 1994, J NEUROSCI METH, V53, P55, DOI 10.1016/0165-0270(94)90144-9
   Chen KH, 2014, CELL MOL NEUROBIOL, V34, P195, DOI 10.1007/s10571-013-0003-z
   Chen SP, 2018, MOL PAIN, V14, DOI 10.1177/1744806918793232
   Chen YC, 2011, BREAKING FEM WAVES, P1, DOI 10.1057/9780230119185
   Chia KL, 2016, J INTEGR MED-JIM, V14, P128, DOI 10.1016/S2095-4964(16)60246-7
   CHOI Y, 1994, PAIN, V59, P369, DOI 10.1016/0304-3959(94)90023-X
   Chung JM, 2004, MOL INTERV, V4, P248, DOI 10.1124/mi.4.5.3
   Close GL, 2004, EUR J APPL PHYSIOL, V91, P615, DOI 10.1007/s00421-003-1012-2
   Djordjevic VB, 2004, INT REV CYTOL, V237, P57, DOI 10.1016/S0074-7696(04)37002-6
   Gao X, 2008, PAIN, V23, P1
   Gwak YS, 2013, PAIN, V154, P1699, DOI 10.1016/j.pain.2013.05.018
   Hacimuftuoglu A, 2006, BEHAV BRAIN RES, V173, P211, DOI 10.1016/j.bbr.2006.06.030
   Hamilton CB, 2015, OSTEOARTHR CARTILAGE, V23, P1178, DOI 10.1016/j.joca.2015.03.001
   Herzberg D, 2019, ANIMALS-BASEL, V9, DOI 10.3390/ani9090693
   Jindong C, 2007, CHIN MED J, V87, P602
   Khalil Z, 2001, FREE RADICAL BIO MED, V31, P430, DOI 10.1016/S0891-5849(01)00597-4
   Khattab MM, 2006, EUR J PHARMACOL, V548, P167, DOI 10.1016/j.ejphar.2006.08.007
   Kim HK, 2010, ANESTHESIOLOGY, V112, P432, DOI 10.1097/ALN.0b013e3181ca31bd
   Kim HY, 2015, NEURAL PLAST, V2015, DOI 10.1155/2015/293423
   Kim HY, 2008, NEUROSCI LETT, V447, P87, DOI 10.1016/j.neulet.2008.09.041
   Kim HK, 2004, PAIN, V111, P116, DOI 10.1016/j.pain.2004.06.008
   Lee DZ, 2012, PAIN, V153, P1905, DOI 10.1016/j.pain.2012.06.001
   Lee I, 2007, PAIN, V133, P9, DOI 10.1016/j.pain.2007.01.035
   Liao HY, 2017, SCI REP-UK, V7, DOI 10.1038/srep42531
   Maioli NA, 2015, BRAZ J MED BIOL RES, V48, P321, DOI [10.1590/1414-431X20144187, 10.1590/1414-431x20144187]
   Nagakura Y, 2003, J PHARMACOL EXP THER, V306, P490, DOI 10.1124/jpet.103.050781
   SIEMS WG, 1995, LIFE SCI, V57, P785, DOI 10.1016/0024-3205(95)02006-5
   Singh AK, 2017, INFLAMM RES, V66, P911, DOI 10.1007/s00011-017-1072-0
   Stadtman ER, 2004, CURR MED CHEM, V11, P1105, DOI 10.2174/0929867043365341
   Thirupathi A, 2018, J PHYSIOL BIOCHEM, V74, P359, DOI 10.1007/s13105-018-0633-1
   Valko M, 2006, CHEM-BIOL INTERACT, V160, P1, DOI 10.1016/j.cbi.2005.12.009
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Walsh NE, 2017, BRIT MED BULL, V122, P151, DOI 10.1093/bmb/ldx012
   Wang ZQ, 2004, J PHARMACOL EXP THER, V309, P869, DOI 10.1124/jpet.103.064154
   Xie WR, 2016, J NEUROSCI, V36, P8712, DOI 10.1523/JNEUROSCI.4118-15.2016
   Zhou YQ, 2018, PHARMACOL RES, V134, P305, DOI 10.1016/j.phrs.2018.07.002
   Zhou YQ, 2018, REDOX BIOL, V14, P391, DOI 10.1016/j.redox.2017.10.011
NR 43
TC 8
Z9 8
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
EI 1744-8069
J9 MOL PAIN
JI Mol. Pain
PD JUN
PY 2020
VL 16
AR 1744806920929246
DI 10.1177/1744806920929246
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA ME5WI
UT WOS:000544725500001
PM 32552357
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ogawa-Ochiai, K
   Yoshimura, K
   Takebe, T
   Iwahashi, M
   Shirai, A
   Tsuda, M
   Ogawa, M
   Ishikawa, H
AF Ogawa-Ochiai, Keiko
   Yoshimura, Kenichi
   Takebe, Takae
   Iwahashi, Mako
   Shirai, Akiko
   Tsuda, Masaki
   Ogawa, Masao
   Ishikawa, Hideki
TI The effect of contact needle therapy on fatigue in patients with cancer
   in palliative care A study protocol for a randomized controlled trial
SO MEDICINE
LA English
DT Article
DE best supportive care; contact needle therapy; general fatigue; Japanese
   traditional (Kampo) medicine; randomized controlled trial
ID ACUPUNCTURE
AB Introduction: Almost all patients with end-of-life cancer experience cancer-related fatigue; however, there are only a few known effective coping methods.
   Objectives : We will conduct a prospective, multi-center, single-blinded randomized controlled study to evaluate the efficacy of acupuncture for cancer-related fatigue in patients with end-of-life cancer.
   Methods: We will enroll 120 patients with cancer hospitalized in a palliative care unit or receiving consultation from a palliative care team in four hospitals. We will add acupuncture treatment; specifically, contact needle therapy (CNT), consisting of an intervention per week period to the usual care. The primary outcome measure will be the Cancer Fatigue Scale (CFS) score while the secondary outcome measures will be the Numerical Rating Scale (NRS) score for fatigue, pain, and salivary amylase levels.
   Conclusion: We will evaluate the possibility of using acupuncture therapy, that is, CNT, in relieving fatigue sensation in patients with advanced cancer.
C1 [Ogawa-Ochiai, Keiko; Iwahashi, Mako; Shirai, Akiko] Kanazawa Univ Hosp, Dept Japanese Tradit Kampo Med, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan.
   [Yoshimura, Kenichi] Hiroshima Univ, Hiroshima Univ Hosp, Ctr Integrated Med Res, Hiroshima, Japan.
   [Yoshimura, Kenichi] Kanazawa Univ Hosp, Innovat Clin Res Ctr, Kanazawa, Ishikawa, Japan.
   [Takebe, Takae; Tsuda, Masaki] Mukeido Clin Acupuncture, Toyama, Japan.
   [Ogawa, Masao] Kanazawa Univ Hosp, Dept Anesthesiol, Kanazawa, Ishikawa, Japan.
   [Ishikawa, Hideki] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Targeting Canc Prevent, Osaka, Japan.
C3 Kanazawa University; Hiroshima University; Kanazawa University; Kanazawa
   University; Kyoto Prefectural University of Medicine
RP Ogawa-Ochiai, K (corresponding author), Kanazawa Univ Hosp, Dept Japanese Tradit Kampo Med, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan.
EM ikkandoo@gmail.com
CR [Anonymous], 2013, TRADITIONAL MED STRA
   Chan AW, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.e7586
   Hagelin CL, 2006, SUPPORT CARE CANCER, V14, P320, DOI 10.1007/s00520-005-0886-4
   Kimata-Kumagai Y, 2017, Palliative Care Research, V12, P781, DOI 10.2512/jspm.12.781
   Leng G, 2013, ACUPUNCT MED, V31, P16, DOI 10.1136/acupmed-2012-010230
   Mucke M, 2015, COCHRANE DB SYST REV, V7, P23
   National Comprehensive Cancer Network (NCCN), 2019, CANC REL FAT
   Ogawa K, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/928129
   Okuyama T, 2000, J PAIN SYMPTOM MANAG, V19, P5, DOI 10.1016/S0885-3924(99)00138-4
   Yennurajalingam S, 2013, J CLIN ONCOL, V31, P3076, DOI 10.1200/JCO.2012.44.4661
   Zhang Y, 2018, SUPPORT CARE CANCER, V26, P415, DOI 10.1007/s00520-017-3955-6
NR 11
TC 0
Z9 0
U1 3
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2019
VL 98
IS 44
AR e17809
DI 10.1097/MD.0000000000017809
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JO7BV
UT WOS:000497731800125
PM 31689865
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Luo, XC
   Liu, JL
   Yao, MH
   Chen, YM
   Fan, AY
   Liang, FR
   Zhao, JP
   Zhao, L
   Zhou, X
   Zhong, XY
   Yang, JIH
   Li, B
   Zhang, Y
   Sun, X
   Li, L
AF Luo, Xiao-chao
   Liu, Jia-li
   Yao, Ming-hong
   Chen, Ye-meng
   Fan, Arthur Yin
   Liang, Fan-rong
   Zhao, Ji-ping
   Zhao, Ling
   Zhou, Xu
   Zhong, Xiao-ying
   Yang, J. Ia-hui
   Li, Bo
   Zhang, Ying
   Sun, Xin
   Li, Ling
TI Specific effect of inserted sham acupuncture and its impact on the
   estimation of acupuncture treatment effect in randomized controlled
   trials: A systematic survey
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Review
DE Acupuncture; Placebos; Randomized controlled trial; Treatment outcome
ID LOW-BACK-PAIN; KNEE OSTEOARTHRITIS; ADJUNCTIVE THERAPY; BREAST-CANCER;
   PLACEBO; MIGRAINE; WOMEN; ELECTROACUPUNCTURE; METAANALYSIS; MULTICENTER
AB Background: The use of inserted sham acupuncture as a placebo in randomized controlled trials (RCTs) is controversial, because it may produce specific effects that cause an underestimation of the effect of acupuncture treatment. Objective: This systematic survey investigates the magnitude of insert-specific effects of sham acupuncture and whether they affect the estimation of acupuncture treatment effects. Search strategy: PubMed, Embase and Cochrane Central Register of Controlled Trials were searched to identify acupuncture RCTs from their inception until December 2022. Inclusion criteria: RCTs that evaluated the effects of acupuncture compared to sham acupuncture and no treatment. Data extraction and analysis: The total effect measured for an acupuncture treatment group in RCTs were divided into three components, including the natural history and/or regression to the mean effect (controlled for no-treatment group), the placebo effect, and the specific effect of acupuncture. The first two constituted the contextual effect of acupuncture, which is mimicked by a sham acupuncture treatment group. The proportion of acupuncture total effect size was considered to be 1. The proportion of natural history and/or regression to the mean effect (PNE) and proportional contextual effect (PCE) of included RCTs were pooled using meta-analyses with a random-effect model. The proportion of acupuncture placebo effect was the difference between PCE and PNE in RCTs with non-inserted sham acupuncture. The proportion of insert-specific effect of sham acupuncture (PIES) was obtained by subtracting the proportion of acupuncture placebo effect and PNE from PCE in RCTs with inserted sham acupuncture. The impact of PIES on the estimation of acupuncture's treatment effect was evaluated by quantifying the percentage of RCTs that the effect of outcome changed from no statistical difference to statistical differ-ence after removing PIES in the included studies, and the impact of PIES was externally validated in other acupuncture RCTs with an inserted sham acupuncture group that were not used to calculate PIES. Results: This analysis included 32 studies with 5492 patients. The overall PNE was 0.335 (95% confidence interval [CI], 0.255-0.415) and the PCE of acupuncture was 0.639 (95% CI, 0.567-0.710) of acupuncture's total effect. The proportional contribution of the placebo effect to acupuncture's total effect was 0.191, and the PIES was 0.189. When we modeled the exclusion of the insert-specific effect of sham acupunc-ture, the acupuncture treatment effect changed from no difference to a significant difference in 45.45% of the included RCTs, and in 40.91% of the external validated RCTs. Conclusion: The insert-specific effect of sham acupuncture in RCTs represents 18.90% of acupuncture's total effect and significantly affects the evaluation of the acupuncture treatment effect. More than 40% of RCTs that used inserted sham acupuncture would draw different conclusions if the PIES had been con-trolled for. Considering the impact of the insert-specific effect of sham acupuncture, caution should be taken when using inserted sham acupuncture placebos in R CTs. Please cite this article as: Luo XC, Liu JL, Yao MH, Chen YM, Fan AY, Liang FR, Zhao JP, Zhao L, Zhou X, Zhong XY, Yang JH, Li B, Zhang Y, Sun X, Li L. Specific effect of inserted sham acupuncture and its impact on the estimation of acupuncture treatment effect in randomized controlled trials: A systematic survey. J Integr Med. 2025; 23(6):630-640.
   (c) 2025 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Luo, Xiao-chao; Liu, Jia-li; Yao, Ming-hong; Sun, Xin; Li, Ling] Sichuan Univ, West China Hosp, Inst Integrated Tradit Chinese & Western Med, Chengdu 610041, Sichuan, Peoples R China.
   [Luo, Xiao-chao; Liu, Jia-li; Yao, Ming-hong; Sun, Xin; Li, Ling] Sichuan Univ, Chinese Evidence Based Med Ctr, Cochrane China Ctr, Chengdu 610041, Sichuan, Peoples R China.
   [Luo, Xiao-chao; Liu, Jia-li; Yao, Ming-hong; Sun, Xin; Li, Ling] Sichuan Univ, West China Hosp, MAGIC China Ctr, Chengdu 610041, Sichuan, Peoples R China.
   [Luo, Xiao-chao; Liu, Jia-li; Yao, Ming-hong; Sun, Xin; Li, Ling] NMPA Key Lab Real World Data Res & Evaluat Hainan, Chengdu 610041, Sichuan, Peoples R China.
   [Luo, Xiao-chao; Liu, Jia-li; Yao, Ming-hong; Sun, Xin; Li, Ling] Sichuan Ctr Technol Innovat Real World Data, Chengdu 610041, Sichuan, Peoples R China.
   [Chen, Ye-meng] New York Coll Tradit Chinese Med, Mineola, NY 11501 USA.
   [Fan, Arthur Yin] McLean Ctr Complementary & Alternat Med PLC, Vienna, VA 22182 USA.
   [Liang, Fan-rong; Zhao, Ling] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu 611137, Sichuan, Peoples R China.
   [Zhao, Ji-ping] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Acupuncture & Moxibust, Beijing 100700, Peoples R China.
   [Zhou, Xu] Jiangxi Univ Tradit Chinese Med, Evidence Based Med Res Ctr, Sch Basic Sci, Nanchang 330004, Jiangxi, Peoples R China.
   [Zhong, Xiao-ying] Beijing Univ Chinese Med, Dongzhimen Hosp, Key Lab Chinese Internal Med, Minist Educ, Beijing 100700, Peoples R China.
   [Yang, J. Ia-hui] Jiangxi Univ Tradit Chinese Med, Coll Acupuncture & Massage, Nanchang 330004, Jiangxi, Peoples R China.
   [Li, Bo] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin 300381, Peoples R China.
   [Li, Bo] Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin 300381, Peoples R China.
   [Zhang, Ying] Guanganmen Hosp, China Acad Chinese Med Sci, Dept Oncol, Beijing 100053, Peoples R China.
   [Sun, Xin] Sichuan Univ, West China Sch Publ Hlth, Dept Epidemiol & Biostat, Chengdu 610041, Sichuan, Peoples R China.
   [Sun, Xin] Sichuan Univ, West China Hosp 4, Chengdu 610041, Sichuan, Peoples R China.
   [Li, Ling] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON L8S 4K1, Canada.
C3 Sichuan University; Sichuan University; Sichuan University; Chengdu
   University of Traditional Chinese Medicine; Beijing University of
   Chinese Medicine; Jiangxi University of Traditional Chinese Medicine;
   Beijing University of Chinese Medicine; Jiangxi University of
   Traditional Chinese Medicine; Tianjin University of Traditional Chinese
   Medicine; Guang'anmen Hospital, CACMS; China Academy of Chinese Medical
   Sciences; Sichuan University; Sichuan University; McMaster University
RP Sun, X; Li, L (corresponding author), Sichuan Univ, West China Hosp, Inst Integrated Tradit Chinese & Western Med, Chengdu 610041, Sichuan, Peoples R China.; Sun, X; Li, L (corresponding author), Sichuan Univ, Chinese Evidence Based Med Ctr, Cochrane China Ctr, Chengdu 610041, Sichuan, Peoples R China.; Sun, X; Li, L (corresponding author), Sichuan Univ, West China Hosp, MAGIC China Ctr, Chengdu 610041, Sichuan, Peoples R China.; Sun, X; Li, L (corresponding author), NMPA Key Lab Real World Data Res & Evaluat Hainan, Chengdu 610041, Sichuan, Peoples R China.; Sun, X; Li, L (corresponding author), Sichuan Ctr Technol Innovat Real World Data, Chengdu 610041, Sichuan, Peoples R China.
EM sunxin@wchscu.cn; liling@wchscu.cn
FU National Key R&D Program of China [2023YFC3503300, 2023YFC3503304];
   National Natural Science Foundation of China for Distinguished Young
   Scholars [82225049, 82305045]; Fundamental Research Funds for the
   Central Public Welfare Research Institutes [2020YJSZX-3]
FX This work was supported by the National Key R&D Program of China (No.
   2023YFC3503300 and No. 2023YFC3503304) , National Natural Science
   Foundation of China for Distinguished Young Scholars (No. 82225049) and
   Youths (No. 82305045) , and Fundamental Research Funds for the Central
   Public Welfare Research Institutes (No. 2020YJSZX-3) . The
   Funding was not involved in the study design, data collection,
   management, analysis, and interpretation.
CR Bao T, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.0681
   Berman BM, 2004, ANN INTERN MED, V141, P901, DOI 10.7326/0003-4819-141-12-200412210-00006
   Birch S, 2022, INTEGR MED RES, V11, DOI 10.1016/j.imr.2021.100725
   Brinkhaus B, 2006, ARCH INTERN MED, V166, P450
   Brinkhaus B, 2013, ANN INTERN MED, V158, P225, DOI 10.7326/0003-4819-158-4-201302190-00002
   Ceballos-Laita L, 2021, ARCH PHYS MED REHAB, V102, P959, DOI 10.1016/j.apmr.2021.01.077
   Chen AT, 2020, OSTEOARTHR CARTILAGE, V28, P1154, DOI 10.1016/j.joca.2020.05.007
   Cherkin DC, 2009, ARCH INTERN MED, V169, P858, DOI 10.1001/archinternmed.2009.65
   Choi JY, 2010, J ASTHMA, V47, P774, DOI 10.3109/02770903.2010.485665
   Choi SM, 2013, ALLERGY, V68, P365, DOI 10.1111/all.12053
   Colquhoun D, 2013, ANESTH ANALG, V116, P1360, DOI 10.1213/ANE.0b013e31828f2d5e
   Deng SZ, 2015, EXP THER MED, V10, P1247, DOI 10.3892/etm.2015.2653
   Di Blasi Z, 2001, LANCET, V357, P757, DOI 10.1016/S0140-6736(00)04169-6
   Evers AWM, 2018, PSYCHOTHER PSYCHOSOM, V87, P204, DOI 10.1159/000490354
   Fei YT, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj-2021-064345
   FISHER S, 1965, PSYCHOPHARMACOLOGIA, V7, P57, DOI 10.1007/BF00404165
   FREEMAN MF, 1950, ANN MATH STAT, V21, P607, DOI 10.1214/aoms/1177729756
   Gaubeca-Gilarranz A, 2018, ACUPUNCT MED, V36, P302, DOI 10.1136/acupmed-2017-011566
   Gol AS, 2021, COMPLEMENT THER CLIN, V45, DOI 10.1016/j.ctcp.2021.101466
   Haflidadóttir SH, 2021, TRIALS, V22, DOI 10.1186/s13063-021-05454-8
   Harbach H, 2007, EUR J ANAESTH, V24, P370, DOI 10.1017/S0265021506001906
   Hedges LV, 1999, ECOLOGY, V80, P1150, DOI 10.1890/0012-9658(1999)080[1150:TMAORR]2.0.CO;2
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Higgins J, 2023, Cochrane handbook for systematic reviews of interventions version 6.4
   Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928
   Kim TH, 2022, J ACUPUNCT MERIDIAN, V15, P333, DOI 10.51507/j.jams.2022.15.6.333
   Kim TH, 2022, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.834112
   KLEIJNEN J, 1994, LANCET, V344, P1347, DOI 10.1016/S0140-6736(94)90699-8
   Krause F, 2020, ADDICT BEHAV, V110, DOI 10.1016/j.addbeh.2020.106488
   Leibing E, 2002, PAIN, V96, P189, DOI 10.1016/S0304-3959(01)00444-4
   Li GY, 2013, EXP THER MED, V6, P699, DOI 10.3892/etm.2013.1225
   Li L, 2020, J CLIN EPIDEMIOL, V123, P80, DOI 10.1016/j.jclinepi.2020.03.017
   Li ZJ, 2017, CEPHALALGIA, V37, P161, DOI 10.1177/0333102416641665
   Linde K, 2005, JAMA-J AM MED ASSOC, V293, P2118, DOI 10.1001/jama.293.17.2118
   Liu JL, 2022, J CLIN EPIDEMIOL, V152, P1, DOI 10.1016/j.jclinepi.2022.09.008
   Liu JL, 2022, ACUPUNCT MED, V40, P524, DOI 10.1177/09645284221117848
   Liu K, 2023, ACUPUNCT HERB MED, V3, P55, DOI 10.1097/HM9.0000000000000058
   Lund Irene, 2006, Acupunct Med, V24, P13
   Lundeberg T, 2008, ACUPUNCT MED, V26, P239, DOI 10.1136/aim.26.4.239
   MacPherson H, 2008, NEUROSCI LETT, V434, P144, DOI 10.1016/j.neulet.2008.01.058
   MacPherson H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093739
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Mavrommatis CI, 2012, PAIN, V153, P1720, DOI 10.1016/j.pain.2012.05.005
   McGeeney BE, 2015, HEADACHE, V55, P465, DOI 10.1111/head.12524
   Melchart D, 2005, BMJ-BRIT MED J, V331, P376, DOI 10.1136/bmj.38512.405440.8F
   Moffet HH, 2009, J ALTERN COMPLEM MED, V15, P213, DOI 10.1089/acm.2008.0356
   Moura CD, 2019, REV ESC ENFERM USP, V53, DOI [10.1590/S1980-220X2018009003418, 10.1590/s1980-220x2018009003418]
   Olausson H, 2002, NAT NEUROSCI, V5, P900, DOI 10.1038/nn896
   Paterson C, 2005, BMJ-BRIT MED J, V330, P1202, DOI 10.1136/bmj.330.7501.1202
   Prisco MK, 2013, MED ACUPUNCT, V25, P407, DOI 10.1089/acu.2013.0989
   Scharf HP, 2006, ANN INTERN MED, V145, P12, DOI 10.7326/0003-4819-145-1-200607040-00005
   Shi GX, 2011, CLIN J PAIN, V27, P258, DOI 10.1097/AJP.0b013e3181fb27ae
   Smith C, 2002, COMPLEMENT THER MED, V10, P210, DOI 10.1016/S0965-2299(02)00072-9
   Smith C, 2013, ACUPUNCT MED, V31, P9, DOI 10.1136/acupmed-2012-010228
   Sun X, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.d1569
   Vas J, 2012, PAIN, V153, P1883, DOI 10.1016/j.pain.2012.05.033
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Whiteside N, 2018, CLIN RHEUMATOL, V37, P1375, DOI 10.1007/s10067-017-3948-3
   Wild B, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0236004
   Witt C, 2005, LANCET, V366, P136, DOI 10.1016/S0140-6736(05)66871-7
   Wu XK, 2017, JAMA-J AM MED ASSOC, V317, P2502, DOI 10.1001/jama.2017.7217
   Xu SB, 2020, BMJ-BRIT MED J, V368, DOI 10.1136/bmj.m697
   Yin X, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.20563
   Zeng D, 2022, EUR J PAIN, V26, P1006, DOI 10.1002/ejp.1924
   Zhang CS, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140825
   Zhang WY, 2018, CLIN IMMUNOL, V186, P82, DOI 10.1016/j.clim.2017.07.018
   Zhang WT, 2004, NEUROSCI LETT, V354, P50, DOI 10.1016/j.neulet.2003.09.080
   Zhang ZJ, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/429412
   Zhao FY, 2022, WORLD J ACUPUNCT-MOX, V32, P1, DOI 10.1016/j.wjam.2021.07.005
   Zhao L, 2019, JAMA INTERN MED, V179, P1388, DOI 10.1001/jamainternmed.2019.2407
   Zhao L, 2017, JAMA INTERN MED, V177, P508, DOI 10.1001/jamainternmed.2016.9378
   Zheng H, 2019, J CLIN HYPERTENS, V21, P412, DOI 10.1111/jch.13490
   Zou K, 2016, ANN RHEUM DIS, V75, P1964, DOI 10.1136/annrheumdis-2015-208387
NR 73
TC 0
Z9 0
U1 4
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD NOV
PY 2025
VL 23
IS 6
BP 630
EP 640
DI 10.1016/j.joim.2025.07.011
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA A5832
UT WOS:001619667500004
PM 40796482
DA 2026-01-16
ER

PT J
AU Nguyen, MD
   Tran, TV
   Nguyen, QV
   Ha, CD
   Dang, LVP
AF Nguyen, Minh Duc
   Tran, Thanh Van
   Nguyen, Quoc Vinh
   Ha, Cay Doan
   Dang, Linh Vu Phuong
TI Effectiveness of bee venom acupuncture for patients suffering from
   periarthritis humeroscapularis
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE periarthritis humeroscapularis; bee venom acupuncture; visual analogue
   scale; range of motion; articular; shoulder function score; inflammatory
   cytokines
ID SHOULDER PAIN; DISORDERS
AB OBJECTIVE: To evaluate the efficacy of bee venom acupuncture in humeroscapularis (PHS) patients. METHODS: One hundred and twenty patients diagnosed with PHS were assigned into four groups: BV1 (0.01 mg/kg), BV2 (0.005 mg/kg), BV3 (0.0025 mg/kg), and control group (vitamin B1 plus novocain 3% injection) with 15 d of treatment. The outcomes of the study including visual analogue scale (VAS) score and [3-endorphin, inflammatory cytokines including interleukin-10 (IL-10), IL-1[3 and tumor necrosis factor & alpha; (TNF-& alpha;) and shoulder function score were assessed at baseline, after 10 and 15 d of treatment. RESULTS: All four groups reported statistically significant improvement in VAS score, motion range, and shoulder function score (P < 0.01), only the BV3 group showed significant increase of anti-inflammatory (IL-10) and decrease of pro-inflammatory (IL-1[3, TNF-& alpha;) cytokines after treatment (P < 0.05). The BV3 group presented a significant difference between all outcomes compared to the control and other groups. CONCLUSION: BV3 groups showed better recovery including reduced pain, improved motor function and normalized inflammatory cytokines than current therapy used in Vietnam and other groups. & COPY; 2023 JTCM. All rights reserved.
C1 [Nguyen, Minh Duc] Natl Hosp Acupuncture, Specialist Clin, Hanoi 1000, Vietnam.
   [Tran, Thanh Van] Natl Hosp Acupuncture, Dept Sr Specialist, Hanoi 1000, Vietnam.
   [Nguyen, Quoc Vinh] Mil Inst Tradit Med, Dept Sr Specialist, Hanoi 1000, Vietnam.
   [Ha, Cay Doan] Natl Hosp Acupuncture, Dept Minimally Invas Spine, Hanoi 1000, Vietnam.
   [Dang, Linh Vu Phuong] Dai Nam Univ, Dept Med, Hanoi 1000, Vietnam.
RP Dang, LVP (corresponding author), Dai Nam Univ, Dept Med, Hanoi 1000, Vietnam.
EM phuonglinh.j@gmail.com
RI Dang, Linh/NKO-9732-2025; Minh Duc, Nguyen/AAL-2426-2020
CR Asheghan Mahsa, 2016, Mater Sociomed, V28, P253, DOI 10.5455/msm.2016.28.253-257
   Ben-Arie E, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/9790470
   Brien S, 2004, EVID-BASED COMPL ALT, V1, P251, DOI 10.1093/ecam/neh035
   Chen Jun, 2008, Shengli Xuebao, V60, P645
   Chung HJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168120
   CONSTANT CR, 1987, CLIN ORTHOP RELAT R, P160
   Cyriax J, 1982, TXB ORTHOPAEDICS MED, V2nd, P191
   DUELTGEN C, 1960, Arch Phys Ther (Leipz), V12, P123
   Gu SM, 2015, J NEUROINFLAMM, V12, DOI 10.1186/s12974-015-0344-2
   Ham HJ, 2019, TRANSL NEURODEGENER, V8, DOI 10.1186/s40035-019-0167-7
   Hand GCR, 2007, J BONE JOINT SURG BR, V89B, P928, DOI 10.1302/0301-620X.89B7.19097
   Kim YS, 2005, EVID-BASED COMPL ALT, V2, P325, DOI 10.1093/ecam/neh102
   KOBUROVA K L, 1985, Acta Physiologica et Pharmacologica Bulgarica, V11, P50
   Koh PS, 2013, J SHOULDER ELB SURG, V22, P1053, DOI 10.1016/j.jse.2012.10.045
   Kwon YB, 2001, PAIN, V90, P271, DOI 10.1016/S0304-3959(00)00412-7
   Lee JD, 2005, EVID-BASED COMPL ALT, V2, P79, DOI 10.1093/ecam/neh070
   Lee JA, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-006140
   Lee MS, 2008, J PAIN, V9, P289, DOI 10.1016/j.jpain.2007.11.012
   Lee SH, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/3549878
   Lee WR, 2015, TOXINS, V7, P4758, DOI 10.3390/toxins7114758
   Li D, 2016, TOXINS BASEL, P8
   Lim SM, 2015, J INTEGR MED-JIM, V13, P241, DOI 10.1016/S2095-4964(15)60178-9
   Niewald M, 2007, RADIAT ONCOL, V2, DOI 10.1186/1748-717X-2-34
   OLDBERG S, 1972, UPSALA J MED SCI, V77, P143, DOI 10.1517/03009734000000022
   Park HJ, 2007, BIOCHEM PHARMACOL, V73, P237, DOI 10.1016/j.bcp.2006.09.023
   Park JH, 2010, INT J TOXICOL, V29, P49, DOI 10.1177/1091581809353948
   PENG CHL, 1978, COMP MED EAST WEST, V6, P57, DOI 10.1142/S0147291778000083
   Shen L, 2020, J PHARMACOPUNCT, V23, P44, DOI 10.3831/KPI.2020.23.008
   Sung SH, 2021, TOXINS BASEL, P13
   Szczudlik A, 1983, Neurol Neurochir Pol, V17, P535
   Urwin M, 1998, ANN RHEUM DIS, V57, P649, DOI 10.1136/ard.57.11.649
   vanderWindt DAWM, 1996, BRIT J GEN PRACT, V46, P519
   WAGENHAU.FJ, 1969, DEUT MED WOCHENSCHR, V94, P1579, DOI 10.1055/s-0028-1110306
   Wang J, 1993, J Tradit Chin Med, V13, P262
NR 34
TC 6
Z9 7
U1 1
U2 4
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD AUG
PY 2023
VL 43
IS 4
BP 795
EP 800
DI 10.19852/j.cnki.jtcm.2023.04.002
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA M5HJ8
UT WOS:001030523300001
PM 37454265
DA 2026-01-16
ER

PT J
AU Towler, P
   Molassiotis, A
   Brearley, SG
AF Towler, P.
   Molassiotis, A.
   Brearley, S. G.
TI What is the evidence for the use of acupuncture as an intervention for
   symptom management in cancer supportive and palliative care: an
   integrative overview of reviews
SO SUPPORTIVE CARE IN CANCER
LA English
DT Review
DE Acupuncture; Cancer; Symptom management; Complex intervention
ID BREAST-CANCER; COMPLEX INTERVENTIONS; PROSTATE-CANCER; HOT FLASHES; MEN;
   XEROSTOMIA; HOSPICE; FLUSHES; RELIEF; DESIGN
AB This study aims to systematically appraise the evidence for the use of acupuncture for symptom management in cancer and supportive care and to identify recommendations for clinical practice and future research.
   A systematic search was carried out to identify reviews of the use of acupuncture in cancer supportive and palliative care, using MEDLINE, EMBASE, CINAHL, Web of Science, Cochrane Library, British Nursing Index, Index to Theses, Dissertations and Theses (via Proquest) and NHS evidence. Search terms included: acupuncture, cancer and symptoms. Data were extracted for analysis. Reviews were assessed for quality using a five-item checklist but were not excluded from the review on grounds of quality, in order to include a comprehensive scope of the subject.
   Seventeen reviews were included in the review. Evidence was found for the use of acupuncture for treatment-related nausea and vomiting. Benefit was reported for other cancer-related symptoms, including pain, fatigue, hot flushes, xerostomia, dyspnoea and anxiety. Reviewers found a paucity of rigorous trials and heterogeneity of populations, interventions, controls and outcome measures, which challenge the process of systematic review and meta-analysis.
   Acupuncture should be considered for symptom management where there are limited treatment options, using current peer-reviewed guidelines and clinical reasoning. Much of the primary research reported in reviews is innovative and indicates potential benefit for people with cancer-related symptoms. The complexity of acupuncture as an intervention needs to be acknowledged in future research designs and when reviewing research findings. An iterative approach using adequate interventions, appropriate outcome measures and adherence to reporting standards is required to evaluate the efficacy of acupuncture in cancer supportive and palliative care.
C1 [Towler, P.] Univ Manchester, Manchester, Lancs, England.
   [Molassiotis, A.] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester, Lancs, England.
   [Brearley, S. G.] Univ Lancaster, Fac Hlth & Med, Lancaster, England.
C3 University of Manchester; University of Manchester; Lancaster University
RP Brearley, SG (corresponding author), Univ Lancaster, Fac Hlth & Med, Lancaster, England.
EM sarah.brearley@lancaster.ac.uk
RI Brearley, Sarah Grace/A-3257-2011; Molassiotis, Alex/MDS-6695-2025
OI Brearley, Sarah Grace/0000-0003-4764-3276; Molassiotis,
   Alex/0000-0001-6351-9991
FU Cancer Experiences Collaborative; National Cancer Research Institute
FX P. Towler was supported in undertaking this review by a scholarship from
   the Cancer Experiences Collaborative, which was funded by the National
   Cancer Research Institute. We appreciate and acknowledge the
   contribution of Dr J. Brine, subject librarian for Health and Medicine,
   Lancaster University, in undertaking the electronic searches.
CR [Anonymous], 10 questions to help you make sense of qualitative research
   [Anonymous], DIR COMPL THER UK CA
   [Anonymous], EQ EXC
   Barsevick AM, 2006, J PAIN SYMPTOM MANAG, V31, P85, DOI 10.1016/j.jpainsymman.2005.05.015
   Beer TM, 2010, UROLOGY, V76, P1182, DOI 10.1016/j.urology.2010.03.033
   BLOM M, 1992, ORAL SURG ORAL MED O, V73, P293, DOI 10.1016/0030-4220(92)90124-9
   Campbell M, 2000, BRIT MED J, V321, P694, DOI 10.1136/bmj.321.7262.694
   Chao LF, 2009, BREAST CANCER RES TR, V118, P255, DOI 10.1007/s10549-009-0533-8
   Cohen Andrea J, 2005, Integr Cancer Ther, V4, P131, DOI 10.1177/1534735405276419
   Collins JA, 2005, HUM REPROD UPDATE, V11, P103, DOI 10.1093/humupd/dmh058
   Craig P, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1655
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Deng G, 2010, OXFORD TXB PALLIATIV
   Dijkers MPJM, 2009, AM J PHYS MED REHAB, V88, P423, DOI 10.1097/PHM.0b013e31819c59c6
   Dos Santos S, 2010, MED ACUPUNCT, V22, P81, DOI 10.1089/acu.2009.0730
   Ernst Edzard, 2010, J Pain Symptom Manage, V40, pe3, DOI 10.1016/j.jpainsymman.2010.03.010
   Ezzo JM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002285.pub2
   Filshie J, 1996, PALLIATIVE MED, V10, P145, DOI 10.1177/026921639601000209
   Filshie Jacqueline, 2006, Acupunct Med, V24, P172
   Finnegan-John J, 2013, INTEGR CANCER THER, V12, P276, DOI 10.1177/1534735413485816
   Frisk J, 2009, EUR UROL, V55, P156, DOI 10.1016/j.eururo.2008.02.002
   Hammar M, 1999, J UROLOGY, V161, P853, DOI 10.1016/S0022-5347(01)61789-0
   Hopkins Hollis Anne Seton, 2010, Oncol Nurs Forum, V37, pE344, DOI 10.1188/10.ONF.E344-E348
   Johnstone PAS, 2002, PALLIATIVE MED, V16, P235, DOI 10.1191/0269216302pm540oa
   Lee H, 2005, EUR J PAIN, V9, P437, DOI 10.1016/j.ejpain.2004.10.004
   Lee MS, 2009, SUPPORT CARE CANCER, V17, P763, DOI 10.1007/s00520-009-0589-3
   Lee MS, 2009, BREAST CANCER RES TR, V115, P497, DOI 10.1007/s10549-008-0230-z
   Leng G, 1999, PALLIATIVE MED, V13, P163, DOI 10.1191/026921699676243035
   Linde K., 2007, Acupuncture research strategies for establishing an evidence base, P199
   Lu Weidong, 2007, J Soc Integr Oncol, V5, P1, DOI 10.2310/7200.2006.035
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Lu WD, 2010, CURR TREAT OPTION ON, V11, P141, DOI 10.1007/s11864-010-0126-0
   Lundeberg T, 2009, ACUPUNCT MED, V27, P31, DOI 10.1136/aim.2008.000133
   MacPherson H, 2010, ACUPUNCT MED, V28, P83, DOI 10.1136/aim.2009.001370
   Matheson L., 2011, Doing your literature review: Traditional and systematic techniques
   Meidell L, 2009, INT J PALLIAT NURS, V15, P12, DOI 10.12968/ijpn.2009.15.1.37947
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P228, DOI 10.1016/j.ctim.2006.09.009
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   O'Regan D, 2010, AUTON NEUROSCI-BASIC, V157, P96, DOI 10.1016/j.autneu.2010.05.001
   O'Sullivan EM, 2010, ACUPUNCT MED, V28, P191, DOI 10.1136/aim.2010.002733
   Paley CA, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub2
   Paterson C., 2010, European Journal of Oriental Medicine, V6, P36
   Pomeranz B., 2001, Clinical Acupuncture, P1
   Sagar SM, 2008, CURR TREAT OPTION ON, V9, P117, DOI 10.1007/s11864-008-0063-3
   Simcock R, 2013, ANN ONCOL, V24, P776, DOI 10.1093/annonc/mds515
   Simmons B, 2010, J ADV NURS, V66, P1151, DOI 10.1111/j.1365-2648.2010.05262.x
   Standish LJ, 2008, AM J HOSP PALLIAT ME, V25, P298, DOI 10.1177/1049909108315916
   White A, 2009, ACUPUNCT MED, V27, pp1
NR 48
TC 64
Z9 74
U1 0
U2 88
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD OCT
PY 2013
VL 21
IS 10
BP 2913
EP 2923
DI 10.1007/s00520-013-1882-8
PG 11
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 214DB
UT WOS:000324109900031
PM 23868190
DA 2026-01-16
ER

PT J
AU Lin, HC
   Hsu, HC
   Liao, HY
   Chen, ALP
   Lin, YW
AF Lin, Huan-Chin
   Hsu, Hsin-Cheng
   Liao, Hsien-Yin
   Chen, Arbee L. P.
   Lin, Yi-Wen
TI Electroacupuncture Modulates Programmed Cell Death 1 Ligand 1 on
   Peripheral and Central Nervous Systems in a Mouse Fibromyalgia Pain
   Model
SO BIOMEDICINES
LA English
DT Article
DE electroacupuncture; fibromyalgia; PD-L1; TRPV1; spinal cord;
   somatosensory cortex
AB Background: Fibromyalgia, a chronic condition that causes long-lasting pain over several months, is a global medical issue with both personal and societal implications. It is one of the hardest types of pain to heal, given the lack of objective parameters for diagnosis and progression evaluation. The main symptoms of fibromyalgia are long-lasting widespread pain alongside with anxiety, fatigue, sleep disorders, cognitive dysfunction, and obesity. Programmed cell death 1 ligand 1 (PD-L1) has been used as a target in cancer immunotherapy. It can inhibit acute and chronic pain by suppressing nociceptive neuron activity via PD-1 receptors. Methods: The current study aimed to investigate the role of PD-L1/PD1 in a mouse fibromyalgia pain model. Mice were exposed to intermittent cold stress (ICS) to produce a murine fibromyalgia model characterized using von Frey and Hargreaves tests. Results: The ICS-induced mice fibromyalgia pain model showed mechanical (2.26 +/- 0.18 g) and thermal (4.36 +/- 0.31 s) hyperalgesia. Nociceptive responses could be relieved with electroacupuncture, intracerebral PD-L1 injection, or Trpv1 deletion. We also identified a lower PD-1 level in the dorsal root ganglion, spinal cord, thalamus, and somatosensory cortex. In contrast, levels of pain-related kinases increased after fibromyalgia induction, an effect which could be reversed by EA, PD-L1, or Trpv1 deletion. Conclusions: Our findings shed light on the contribution of PD-L1/PD1 to EA and fibromyalgia pain, indicating its potential as a treatment target for fibromyalgia.
C1 [Lin, Huan-Chin; Lin, Yi-Wen] China Med Univ, Grad Inst Acupuncture Sci, Coll Chinese Med, Taichung 404328, Taiwan.
   [Lin, Huan-Chin] Minist Hlth & Welf, Feng Yuan Hosp, Dept Tradit Chinese Med, Taichung, Taiwan.
   [Hsu, Hsin-Cheng] China Med Univ, Hsinchu Hosp, Dept Tradit Chinese Med, Hsinchu 302056, Taiwan.
   [Liao, Hsien-Yin] China Med Univ, Coll Chinese Med, Sch Postbaccalaureate Chinese Med, Taichung 404328, Taiwan.
   [Chen, Arbee L. P.] Asia Univ, Dept Comp Sci & Informat Engn, Taichung 413305, Taiwan.
   [Lin, Yi-Wen] China Med Univ, Chinese Med Res Ctr, Taichung 404328, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Taiwan; Asia University Taiwan; China Medical
   University Taiwan
RP Lin, YW (corresponding author), China Med Univ, Grad Inst Acupuncture Sci, Coll Chinese Med, Taichung 404328, Taiwan.; Chen, ALP (corresponding author), Asia Univ, Dept Comp Sci & Informat Engn, Taichung 413305, Taiwan.; Lin, YW (corresponding author), China Med Univ, Chinese Med Res Ctr, Taichung 404328, Taiwan.
EM peishiuan1010@gmail.com; 002762@tool.caaumed.org.tw;
   017215@tool.caaumed.org.tw; arbeec@mail.asia.edu.tw;
   yiwenlin@mail.cmu.edu.tw
OI Hsu, Hsin-Cheng/0000-0002-9150-0339
FU Ministry of Education in Taiwan; NSTC [113-2314-B-039-047,
   CMU113-ASIA-15, CMUHCH-DRM-113-025]; Chinese Medicine Research Center,
   China Medical University" from The Featured Areas Research Center
   Program
FX This work was supported by the following grants: NSTC
   113-2314-B-039-047, CMU113-ASIA-15, CMUHCH-DRM-113-025, and the "Chinese
   Medicine Research Center, China Medical University" from The Featured
   Areas Research Center Program within the framework of the Higher
   Education Sprout Project by the Ministry of Education in Taiwan.
CR Assavarittirong C, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/1582432
   Benítez-Angeles M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103421
   Brown EN, 2018, ANESTH ANALG, V127, P1246, DOI 10.1213/ANE.0000000000003668
   Chen G, 2017, NAT NEUROSCI, V20, P917, DOI 10.1038/nn.4571
   Farag HM, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.12939
   Fernández-Carvajal A, 2022, FRONT MOL NEUROSCI, V15, DOI 10.3389/fnmol.2022.930964
   Ghowsi M, 2021, BIOMEDICINE-TAIWAN, V11, P13, DOI 10.37796/2211-8039.1174
   Guo L, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2024.e30819
   Hsiao IH, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11182869
   Hsiao IH, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/2242074
   Janssen LP, 2021, AN ACAD BRAS CIENC, V93, DOI 10.1590/0001-3765202120210618
   Kaur A, 2019, BIOCHEM PHARMACOL, V166, P56, DOI 10.1016/j.bcp.2019.05.012
   Koivisto AP, 2024, CURR OPIN PHARMACOL, V75, DOI 10.1016/j.coph.2024.102447
   Kong FQ, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.670646
   Liao HY, 2021, CHIN MED-UK, V16, DOI 10.1186/s13020-021-00451-0
   Lin YW, 2020, BRAIN BEHAV IMMUN, V89, P604, DOI 10.1016/j.bbi.2020.06.033
   Liu BL, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.137386
   Liu F, 2023, BRAIN RES, V1820, DOI 10.1016/j.brainres.2023.148578
   Liu SB, 2021, NATURE, V598, P641, DOI 10.1038/s41586-021-04001-4
   Lu SF, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00353
   Menzies V, 2010, BIOL RES NURS, V11, P387, DOI 10.1177/1099800409348328
   Fischer SPM, 2020, NEUROCHEM INT, V134, DOI 10.1016/j.neuint.2020.104673
   Peck MM, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.10276
   Qin YX, 2013, ACUPUNCT MED, V31, P214, DOI 10.1136/acupmed-2012-010289
   Shi SM, 2020, CEPHALALGIA, V40, P288, DOI 10.1177/0333102419883374
   Siracusa R, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22083891
   Stone JAM, 2010, CURR TREAT OPTION ON, V11, P118, DOI 10.1007/s11864-010-0128-y
   Tan HL, 2021, ANESTH ANALG, V133, P1321, DOI 10.1213/ANE.0000000000005737
   Torres-Rosas R, 2014, NAT MED, V20, P291, DOI 10.1038/nm.3479
   Wang G, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-15229-5
   Wang Y, 2024, CANCER IMMUNOL RES, V12, P26, DOI 10.1158/2326-6066.CIR-23-0309
   Xie LS, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.689629
   Yang B, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.716684
   Yang Y, 2022, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.811584
   Yen LT, 2017, SCI REP-UK, V7, DOI 10.1038/srep46663
   Yüksel E, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17715-1
   Zhang C, 2024, NEUROTHERAPEUTICS, V21, DOI 10.1016/j.neurot.2024.e00369
   Zhao L, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2204114119
   Zhou X, 2024, BRAIN SCI, V14, DOI 10.3390/brainsci14040380
NR 39
TC 1
Z9 1
U1 5
U2 10
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD FEB
PY 2025
VL 13
IS 2
AR 396
DI 10.3390/biomedicines13020396
PG 14
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA Y2L7J
UT WOS:001430510500001
PM 40002809
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Choi, TY
   Ang, L
   Jun, JH
   Alraek, T
   Birch, S
   Lu, WD
   Lee, MS
AF Choi, Tae-Young
   Ang, Lin
   Jun, Ji Hee
   Alraek, Terje
   Birch, Stephen
   Lu, Weidong
   Lee, Myeong Soo
TI Acupuncture for Managing Cancer-Related Fatigue in Breast Cancer
   Patients: A Systematic Review and Meta-Analysis
SO CANCERS
LA English
DT Review
DE acupuncture; cancer; breast; fatigue; systematic review; meta-analysis
ID INHIBITOR-RELATED ARTHRALGIA; DOUBLE-BLIND; THERAPY; MOXIBUSTION;
   SAFETY; WOMEN
AB Simple Summary Acupuncture (AT) itself is not used to treat cancer. AT is used to help manage various side effects (pain, hot flashes, and fatigue) that occur in cancer treatment. However, the mechanism of action and efficacy of AT are uncertain. The purpose of this systematic review and meta-analysis was to explore the benefits of acupuncture in patients with breast cancer-related fatigue (CRF). Breast cancer (BC) is the most common cancer in women and is a serious threat to women's health. Cancer-related fatigue (CRF) is a distressing symptom in BC patients during and after chemotherapy or radiation therapy that severely affects quality of life (QoL). AT is widely used for fatigue management. However, the effect of AT on CRF is still uncertain. This study aimed to evaluate the efficacy and safety of AT in the management of CRF in patients with BC. Eleven databases were searched through June 2022. Two researchers independently performed the database search, study selection, data extraction, and risk of bias assessment. Study selection was performed based on predefined Participants, Intervention, Comparators, Outcomes, Study design (PICOS) criteria, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed when reporting the results. A meta-analysis was performed according to the Cochrane systematic review method using RevMan 5.3. A total of 12 studies including a total of 1084 participants were included. The results showed that AT had a beneficial effect compared with sham AT (n = 256, SMD = -0.26, 95% CI [-0.51, -0.01], p = 0.04, I-2 = 0%) and a long-term effect on fatigue score (n = 209, MD = -0.32, 95% CI [-0.59, -0.04], p = 0.02, I-2 = 0%). Meta-analysis showed that AT had a beneficial effect compared with usual care (UC) on fatigue scores (n = 238, SMD = -0.39, 95% CI [-0.66 to -0.12], p = 0.005, I-2 = 0%). Of the 12 articles, 3 articles were judged as having a low risk of bias in all domains and hence were of high quality. No serious adverse effects were identified. AT is an effective and safe treatment for CRF, and AT is more effective than sham AT or UC or wait-list control (WLC). Nevertheless, the methodological quality of most of these studies was low, and the included studies/sample sizes were small, so the ability to derive decisive implications was limited. Further research is needed to confirm these findings.
C1 [Choi, Tae-Young; Ang, Lin; Jun, Ji Hee; Lee, Myeong Soo] Korea Inst Oriental Med, KM Sci Res Div, Daejeon 34054, South Korea.
   [Alraek, Terje; Birch, Stephen] Kristiania Univ Coll, Sch Hlth Sci, N-0107 Oslo, Norway.
   [Alraek, Terje] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Natl Res Ctr Complementary & Alternat Med NAFKAM, N-9037 Tromso, Norway.
   [Lu, Weidong] Harvard Med Sch USA, Dana Farber Canc Inst, Boston, MA 02115 USA.
C3 Korea Institute of Oriental Medicine (KIOM); Kristiania University
   College; UiT The Arctic University of Tromso; Harvard University;
   Harvard University Medical Affiliates; Dana-Farber Cancer Institute
RP Lee, MS (corresponding author), Korea Inst Oriental Med, KM Sci Res Div, Daejeon 34054, South Korea.
EM drmslee@gmail.com
RI Lee, Myeong Soo/C-8147-2013; Alræk, Terje/AAG-7001-2021; Choi,
   TaeYoung/PAU-6282-2025; Ang, Lin/AAE-7428-2021; Lu, Weidong/C-3844-2008
OI Lee, Myeong Soo/0000-0001-6651-7641; Ang, Lin/0000-0002-7273-9600;
   Birch, Stephen/0000-0001-7986-6568; JUN, JI HEE/0000-0001-9084-903X; Lu,
   Weidong/0000-0003-2838-6307
FU Korea Institute of Oriental Medicine, Korea [KSN2022210]; Pink Ribbon
   [207697-2019]
FX T.Y.C., L.A., J.H.J. and M.S.L. were supported by a grant from the Korea
   Institute of Oriental Medicine, Korea (KSN2022210). T.A. is the PI of an
   ongoing study that is funded by a grant from Pink Ribbon, which is a
   collaboration between the Norwegian Cancer Association and the Breast
   Cancer Society (Contract no.: 207697-2019). The funder had no role in
   the study design, the data collection and analysis, the decision to
   publish, or the preparation of the manuscript.
CR [Anonymous], 2009, BMJ-BRIT MED J, V6, pe1000097, DOI [DOI 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, DOI 10.1371/JOURNAL.PMED.1000097]
   Arring NM, 2019, CANCER J, V25, P349, DOI 10.1097/PPO.0000000000000396
   Berger AM, 2015, J NATL COMPR CANC NE, V13, P1012, DOI 10.6004/jnccn.2015.0122
   Birch S, 2022, INTEGR MED RES, V11, DOI 10.1016/j.imr.2022.100834
   Birch S, 2022, INTEGR MED RES, V11, DOI 10.1016/j.imr.2021.100725
   Birch S, 2019, INTEGR MED RES, V8, P160, DOI 10.1016/j.imr.2019.05.002
   Brinkhaus B, 2019, BREAST CANCER RES TR, V178, P617, DOI 10.1007/s10549-019-05431-5
   Chen J., 2016, JIANGSU J TRADIT CHI, V48, P56
   Chen YP, 2016, J CANCER RES THER, V12, P535, DOI 10.4103/0973-1482.172716
   Cheng CS, 2017, SUPPORT CARE CANCER, V25, P3807, DOI 10.1007/s00520-017-3812-7
   Chien TJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419866910
   Chien TJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180918
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Choi TY, 2022, CANCERS, V14, DOI 10.3390/cancers14102347
   Cybularz PA, 2015, MED ACUPUNCT, V27, P224, DOI 10.1089/acu.2015.1099
   Ebede CC, 2017, MED CLIN N AM, V101, P1085, DOI 10.1016/j.mcna.2017.06.007
   Fabi A, 2020, ANN ONCOL, V31, P713, DOI 10.1016/j.annonc.2020.02.016
   Ferlay J, 2021, INT J CANCER, V149, P778, DOI 10.1002/ijc.33588
   Halamkova J, 2022, Klin Onkol, V35, P94, DOI [10.48095/ccko202294, 10.48095/ccko202294]
   Hou WZ, 2019, J OBSTET GYNAECOL RE, V45, P2307, DOI 10.1111/jog.14122
   Höxtermann MD, 2022, CANCER-AM CANCER SOC, V128, P2159, DOI 10.1002/cncr.34165
   Johnston MF, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-49
   Juvet LK, 2017, BREAST, V33, P166, DOI 10.1016/j.breast.2017.04.003
   Lau CHY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002901
   Lee IS, 2021, INTEGR MED RES, V10, DOI 10.1016/j.imr.2021.100754
   Li HJ, 2021, J ALTERN COMPLEM MED, V27, P1084, DOI 10.1089/acm.2021.0133
   Li YF, 2020, ONCOTARGETS THER, V13, P11743, DOI 10.2147/OTT.S272747
   Liu JP, 2022, INTEGR MED RES, V11, DOI 10.1016/j.imr.2022.100836
   Liu XM, 2021, INTEGR CANCER THER, V20, DOI 10.1177/1534735420980811
   Maass SWMC, 2021, CANCERS, V13, DOI 10.3390/cancers13061301
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Mao HJ, 2016, CANCER-AM CANCER SOC, V122, P3667, DOI 10.1002/cncr.30189
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Minton O, 2008, BREAST CANCER RES TR, V112, P5, DOI 10.1007/s10549-007-9831-1
   Molassiotis A, 2013, ANN ONCOL, V24, P1645, DOI 10.1093/annonc/mdt034
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Noal S, 2011, INT J RADIAT ONCOL, V81, P795, DOI 10.1016/j.ijrobp.2010.06.037
   Pan YQ, 2018, INTEGR CANCER THER, V17, P602, DOI 10.1177/1534735418786801
   Pudkasam S, 2021, MATURITAS, V152, P32, DOI 10.1016/j.maturitas.2021.06.008
   Roldán-Jiménez C, 2022, SUPPORT CARE CANCER, V30, P1243, DOI 10.1007/s00520-021-06470-9
   Saligan LN, 2015, SUPPORT CARE CANCER, V23, P2461, DOI 10.1007/s00520-015-2763-0
   Shih YW, 2021, INTEGR CANCER THER, V20, DOI 10.1177/15347354211063884
   Smith C, 2013, ACUPUNCT MED, V31, P9, DOI 10.1136/acupmed-2012-010228
   Tan JY, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.866284
   Wang XS, 2015, GYNECOL ONCOL, V136, P446, DOI 10.1016/j.ygyno.2014.10.013
   Witt CM, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-148
   Yu M., 2017, CHINA MED HERALD, V14, P89
   Pan YQ, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420940394
   Zhang Y, 2018, SUPPORT CARE CANCER, V26, P415, DOI 10.1007/s00520-017-3955-6
   [张玉 Zhang Yu], 2019, [中医杂志, Journal of Traditional Chinese Medicine], V60, P509
   Zhang YZ, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.646315
   Zhou C., 2018, ACTA CHIN MED, V33, P950, DOI [10.16368/j.issn.1674-8999.2018.06.227, DOI 10.16368/J.ISSN.1674-8999.2018.06.227]
   Zhu DL., 2016, Shanghai journal of acupuncture and moxibustion [shang hai zhen jiu za zhi], V35, P964, DOI 10.13460/j.issn.1005-0957.2016.08.0964
NR 53
TC 27
Z9 31
U1 3
U2 20
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD SEP
PY 2022
VL 14
IS 18
AR 4419
DI 10.3390/cancers14184419
PG 14
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 4S8UM
UT WOS:000857708700001
PM 36139579
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Gianni, C
   Scarpi, E
   Bravaccini, S
   Pirini, F
   Vanni, S
   Dall'Agata, M
   Cortesi, M
   Fanini, F
   Cavalieri, S
   Mercatali, L
   Ulivi, P
   Poini, A
   Giovanardi, CM
   Rocca, A
   Fedeli, A
AF Gianni, Caterina
   Scarpi, Emanuela
   Bravaccini, Sara
   Pirini, Francesca
   Vanni, Silvia
   Dall'Agata, Monia
   Cortesi, Michela
   Fanini, Francesca
   Cavalieri, Sara
   Mercatali, Laura
   Ulivi, Paola
   Poini, Alessandra
   Giovanardi, Carlo Maria
   Rocca, Andrea
   Fedeli, Anna
TI Investigating biochemical markers of Acupuncture's effectiveness in
   managing climacteric syndrome in breast cancer patients: the FLAIR study
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Breast cancer; Acupuncture; Cytokines; Hot flushes; Menopause; TNF-alpha
ID VASOMOTOR SYMPTOMS; HOT FLASHES; WOMEN; INTERLEUKIN-8; METAANALYSIS;
   MECHANISMS; MODEL
AB Background Breast cancer (BC) remains a global health issue, with most women receiving adjuvant hormone therapy. Hot flushes and climacteric symptoms often compromise treatment adherence. Acupuncture has shown promise in alleviating these symptoms and improving quality of life (QoL). This prospective study aimed to investigate the mechanisms underlying acupuncture's effects on menopausal symptoms in breast cancer patients receiving endocrine therapy, with a secondary focus on inflammatory biomarker changes. Methods This open-label biological study enrolled 37 early BC patients receiving endocrine treatment, and acupuncture treatment provided at IRST within the integrative care pathway, of whom 27 completed all evaluations. Participants underwent a 10-session weekly acupuncture program based on Traditional Chinese Medicine, using fixed points (SP6, CV4, LI11, BL11, GB39). Blood samples for biochemical and cytokine analysis (IL-5, IL-6, IL-10, IL-8, IL-22, TNF alpha) were collected at baseline (T0), post-treatment (T1), and six months later (T2) during regular clinical and laboratory workups. Clinical outcomes were assessed using the Green Climacteric Scale (GCS), EQ-5D-5L, and Brief Pain Inventory (BPI). The study followed STRICTA guidelines. Results Acupuncture significantly improved vasomotor and climacteric symptoms, with reduced GCS and hot flash scores at T1 and T2 (p < 0.0001). QoL and pain scores also significantly improved at both time points. Among the cytokines measured over time, a significant reduction in TNF alpha levels was observed (p = 0.006), though no correlation emerged between cytokine changes and clinical outcomes. Conclusions Acupuncture proved effective in improving menopausal symptoms and QoL in BC patients receiving endocrine therapy. The modulation of TNF alpha suggests a potential biological role in the mechanism of symptom relief.
C1 [Gianni, Caterina] IRCCS Ist Romagnolo Studio Tumori IRST, Med Oncol & Breast Unit, Dino Amadori, Via P Maroncelli 40, I-47014 Meldola, FC, Italy.
   [Scarpi, Emanuela; Dall'Agata, Monia] IRCCS Ist Romagnolo Studio Tumori IRST Dino Amador, Unit Biostat & Clin Trials, Via P Maroncelli 40, I-47014 Meldola, FC, Italy.
   [Bravaccini, Sara] Univ Enna Kore, Dept Med & Surg, I-94100 Enna, Italy.
   [Pirini, Francesca; Cortesi, Michela; Ulivi, Paola] IRCCS Ist Romagnolo Studio Tumori IRST Dino Amador, Biosci Lab, Via P Maroncelli 40, I-47014 Meldola, FC, Italy.
   [Vanni, Silvia] IRCCS Ist Romagnolo Studio Tumori IRST Dino Amador, Preclin & Osteoncol Unit, Biosci Lab, Via P Maroncelli 40, I-47014 Meldola, FC, Italy.
   [Fanini, Francesca] IRCCS Ist Romagnolo Studio Tumori IRST Dino Amador, Immuno Gene Therapy Factory, Via P Maroncelli 40, I-47014 Meldola, FC, Italy.
   [Cavalieri, Sara] IRCCS Ist Romagnolo Studio Tumori IRST Dino Amador, Med Oncol, Via P Maroncelli 40, I-47014 Meldola, FC, Italy.
   [Mercatali, Laura] IRCCS Ist Ortoped Rizzoli, Osteoncol Bone & Soft Tissue Sarcomas & Innovat Th, Via Barbiano 1-10, I-40136 Bologna, Italy.
   [Poini, Alessandra; Giovanardi, Carlo Maria; Fedeli, Anna] Assoc Med Acupuncturists Bologna AMAB, Res & Healthcare Inst, Via Antonio Canova 15-E, I-40138 Bologna, Italy.
   [Rocca, Andrea] Univ Trieste, Dept Med Surg & Hlth Sci, Piazza Univ 1, I-34127 Trieste, Italy.
C3 Universita Kore di ENNA; University of Trieste
RP Scarpi, E (corresponding author), IRCCS Ist Romagnolo Studio Tumori IRST Dino Amador, Unit Biostat & Clin Trials, Via P Maroncelli 40, I-47014 Meldola, FC, Italy.
EM caterina.gianni@irst.emr.it; emanuela.scarpi@irst.emr.it;
   sara.bravaccini@unikore.it; francesca.pirini@irst.emr.it;
   silvia.vanni@irst.emr.it; monia.dallagata@irst.emr.it;
   michela.cortesi@irst.emr.it; francesca.fanini@irst.emr.it;
   sara.cavalieri@irst.emr.it; laura.mercatali@ior.it;
   paola.ulivi@irst.emr.it; alessandra.poini@gmail.com;
   carlomariagiovanardi@gmail.com; andrea.rocca@units.it;
   annafedeli60@gmail.com
RI Gianni, Caterina/AAE-3608-2022; Pirini, Francesca/AAC-1153-2020; Vanni,
   Silvia/AAA-7149-2021; Fanini, Francesca/H-6973-2019; cortesi,
   michela/X-1540-2018; Bravaccini, Sara/C-7023-2016; Ulivi,
   Paola/AFV-9220-2022
FU Italian Ministry of Health within the research line "Precision, gender
   and ethnicity-based medicine and geroscience: genetic-molecular
   mechanisms in the development, characterization and treatment of tumors"
   [L3P1986]
FX This work was partly supported thanks to the contribution of Ricerca
   Corrente by the Italian Ministry of Health within the research line
   "Precision, gender and ethnicity-based medicine and geroscience:
   genetic-molecular mechanisms in the development, characterization and
   treatment of tumors" (L3P1986).
CR Abildgaard J, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0235174
   Avis NE, 2008, MENOPAUSE, V15, P1070, DOI 10.1097/gme.0b013e31816d5b03
   Borud EK, 2009, MENOPAUSE, V16, P484, DOI 10.1097/gme.0b013e31818c02ad
   Brennan DJ, 2025, J CLIN ONCOL, V43, P508, DOI 10.1200/JCO.2025.43.16_suppl.508
   Bruun JM, 2003, HORM METAB RES, V35, P142, DOI 10.1055/s-2003-39074
   Caraceni A, 1996, PAIN, V65, P87, DOI 10.1016/0304-3959(95)00156-5
   Chen L, 2017, BREAST, V33, P132, DOI 10.1016/j.breast.2017.03.015
   Chiu HY, 2015, MENOPAUSE, V22, P234, DOI [10.1097/gme.0000000000000260, 10.1097/GME.0000000000000260]
   Cioffi M, 2002, MATURITAS, V41, P187, DOI 10.1016/S0378-5122(01)00286-9
   Di Maio M, 2022, ANN ONCOL, V33, P878, DOI 10.1016/j.annonc.2022.04.007
   Dudakov JA, 2015, ANNU REV IMMUNOL, V33, P747, DOI 10.1146/annurev-immunol-032414-112123
   Franzoi MA, 2021, LANCET ONCOL, V22, pE303, DOI 10.1016/S1470-2045(20)30666-5
   Freedman RR, 2014, J STEROID BIOCHEM, V142, P115, DOI 10.1016/j.jsbmb.2013.08.010
   Frisk JW, 2014, SUPPORT CARE CANCER, V22, P1409, DOI 10.1007/s00520-014-2126-2
   Giaquinto AN, 2022, CA-CANCER J CLIN, V72, P524, DOI 10.3322/caac.21754
   Greene JG, 1998, MATURITAS, V29, P25, DOI 10.1016/S0378-5122(98)00025-5
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Guli A, 2015, Le acque lunari. La medicina cinese e la donna, V3rd
   Harlow SD, 2012, J CLIN ENDOCR METAB, V97, P1159, DOI 10.1210/jc.2011-3362
   Huang WY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184011
   Jung J, 2021, BRAIN BEHAV IMMUN, V94, P424, DOI 10.1016/j.bbi.2021.02.003
   Kalliolias GD, 2016, NAT REV RHEUMATOL, V12, P49, DOI 10.1038/nrrheum.2015.169
   Karaoulanis SE, 2012, ANN GEN PSYCHIATR, V11, DOI 10.1186/1744-859X-11-9
   Korpe B, 2024, MENOPAUSE, V31, P973, DOI 10.1097/GME.0000000000002433
   Kreimeier S, 2019, QUAL LIFE RES, V28, P1951, DOI 10.1007/s11136-019-02115-x
   Lambertini Matteo, 2023, Am Soc Clin Oncol Educ Book, V43, pe390442, DOI [10.1200/edbk_390442, 10.1200/EDBK_390442]
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Lin JG, 2018, CELL TRANSPLANT, V27, P551, DOI 10.1177/0963689717724795
   Maciocia G., 2011, Obstetrics and Gynecology in Chinese Medicine, V2nd
   MacPherson Hugh, 2010, J Evid Based Med, V3, P140, DOI 10.1111/j.1756-5391.2010.01086.x
   Malutan A, 2013, ACTA ENDOCRINOL-BUCH, V9, P133, DOI 10.4183/aeb.2013.133
   Malutan AM, 2014, MENOPAUSE REV, V13, P162, DOI 10.5114/pm.2014.43818
   Mendieta D, 2016, J NEUROIMMUNOL, V290, P22, DOI 10.1016/j.jneuroim.2015.11.011
   Nelson HD, 2008, LANCET, V371, P760, DOI 10.1016/S0140-6736(08)60346-3
   Oh YI, 2012, KIDNEY BLOOD PRESS R, V35, P634, DOI 10.1159/000339640
   Pfeilschifter J, 2002, ENDOCR REV, V23, P90, DOI 10.1210/er.23.1.90
   Rallis KS, 2022, FUTURE ONCOL, V18, P3349, DOI 10.2217/fon-2022-0063
   Ramires CC, 2021, ACUPUNCT MED, V39, P376, DOI 10.1177/0964528420938379
   Scalone L, 2013, VALUE HEALTH, V16, P814, DOI 10.1016/j.jval.2013.04.008
   Shivers KY, 2015, CYTOKINE, V72, P121, DOI 10.1016/j.cyto.2015.01.007
   Song AQ, 2018, CURR MED SCI, V38, P1109, DOI 10.1007/s11596-018-1991-1
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   Wang L, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8253904
   World Health Organization, 2025, ICD-11 for Mortality and Morbidity Statistics (Version: 2025-01)
   Wu LQ, 2019, COMPLEMENT THER CLIN, V37, P11, DOI 10.1016/j.ctcp.2019.08.002
   Yasui T, 2006, J CLIN ENDOCR METAB, V91, P4805, DOI 10.1210/jc.2006-1100
NR 46
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD NOV 20
PY 2025
VL 33
IS 12
AR 1099
DI 10.1007/s00520-025-10181-w
PG 16
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA A6936
UT WOS:001619778600002
PM 41264030
DA 2026-01-16
ER

PT J
AU Zhao, XM
   Liu, L
   Wang, YK
   Wang, G
   Zhao, YK
   Zhang, Y
AF Zhao, Xiaoming
   Liu, Li
   Wang, Yuku
   Wang, Gang
   Zhao, Yingkai
   Zhang, Yao
TI Electroacupuncture Enhances Antioxidative Signal Pathway and Attenuates
   Neuropathic Pain Induced by Chemotherapeutic Paclitaxel
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Electroacupuncture; Paclitaxel; Neuropathic pain; Nrf2-ARE; SOD;
   Oxidative stress
ID RAT MODEL; HYPERALGESIA; MODULATION; ALLODYNIA; RESPONSES; ROLES
AB One of the significant limiting complications of paclitaxel is painful peripheral neuropathy during its therapy for several types of cancers. Our recent study showed that impairment of Nrf2-antioxidant response element (Nrf2-ARE) and upregulation of oxidative signals in the dorsal root ganglion (DRG) of rats with treatment of paclitaxel result in neuropathic pain. The purpose of this study was to examine the beneficial role played by electroacupuncture (EA) in modifying neuropathic pain evoked by paclitaxel via Nrf2-ARE and oxidative mechanisms. Behavioral test was performed to determine mechanical and thermal sensitivity in rats. Western Blot analysis and ELISA were used to examine expression of Nrf2-ARE and superoxide dismutases (SOD); and the levels of products of oxidative stress in the DRG. Our data showed that paclitaxel increased mechanical and thermal sensitivity and this was accompanied with impaired Nrf2-ARE and SOD in the DRG and amplified products of oxidative stress (i.e. 8-isoprostaglandin Fla and 8-hydroxy-2'-deoxyguanosine). EA treatment largely restored the levels of Nrf2-ARE/SOD and inhibited products of oxidative stress and thereby attenuated mechanical and thermal hypersensitivity induced by paclitaxel. In conclusion, we revealed specific signaling pathways leading to paclitaxel-evoked neuropathic pain, including impairment of Nrf2-ARE and heightened oxidative signals. We further provided evidence for the role of EA in alleviating paclitaxel-neuropathic pain via these molecular mediators.
C1 [Zhao, Xiaoming; Liu, Li] Jilin Univ, Hosp 1, Tumor Ctr, Changchun, Jilin, Peoples R China.
   [Wang, Yuku] Jilin Heart Dis Hosp, Changchun, Jilin, Peoples R China.
   [Wang, Gang] Jilin Univ, Hosp 1, Div Operat, Changchun, Jilin, Peoples R China.
   [Zhao, Yingkai] Jilin Univ, Hosp 1, Dept Gerontol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
   [Zhang, Yao] Jilin Univ, Hosp 1, Dept Thorac Surg, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; Jilin University
RP Zhao, YK (corresponding author), Jilin Univ, Hosp 1, Dept Gerontol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.; Zhang, Y (corresponding author), Jilin Univ, Hosp 1, Dept Thorac Surg, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
EM ykz9798@163.com
CR Altenhöfer S, 2012, CELL MOL LIFE SCI, V69, P2327, DOI 10.1007/s00018-012-1010-9
   [Anonymous], 2017, COCHRANE DATABASE SY, DOI [10.1002/14651858.CD012057.pub2/abstract, DOI 10.1002/14651858.CD012057.PUB2/ABSTRACT]
   Cata JP, 2008, BRAIN RES, V1229, P100, DOI 10.1016/j.brainres.2008.07.001
   CHAPLAN SR, 1994, J NEUROSCI METH, V53, P55, DOI 10.1016/0165-0270(94)90144-9
   Chen Y, 2011, NEUROSCIENCE, V193, P440, DOI 10.1016/j.neuroscience.2011.06.085
   Choi EM, 2012, CHIN MED-UK, V7, DOI 10.1186/1749-8546-7-4
   DeLeo JA, 2001, PAIN, V90, P1, DOI 10.1016/S0304-3959(00)00490-5
   Dougherty PM, 2004, PAIN, V109, P132, DOI 10.1016/j.pain.2004.01.021
   Duggett NA, 2016, NEUROSCIENCE, V333, P13, DOI 10.1016/j.neuroscience.2016.06.050
   Fidanboylu M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025212
   Gavazzi G, 2006, FEBS LETT, V580, P497, DOI 10.1016/j.febslet.2005.12.049
   Ghersi D, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003366.pub3
   Gold R, 2012, NEW ENGL J MED, V367, P1098, DOI 10.1056/NEJMoa1114287
   Griffiths LA, 2015, J PAIN, V16, P981, DOI 10.1016/j.jpain.2015.06.008
   Hanna M., 2013, Cancer Pain
   Hoskin PJ, 2008, Clinical Pain Management: Cancer Pain, V2nd, P251, DOI [10.1201/b13440-19, DOI 10.1201/B13440-19]
   Janes K, 2013, PAIN, V154, P2432, DOI 10.1016/j.pain.2013.07.032
   Kallenborn-Gerhardt W, 2012, J NEUROSCI, V32, P10136, DOI 10.1523/JNEUROSCI.6227-11.2012
   Kavoussi B, 2007, INTEGR CANCER THER, V6, P251, DOI 10.1177/1534735407305892
   Kim HK, 2017, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00532
   Kim HK, 2016, PAIN PHYSICIAN, V19, pE589, DOI 10.36076/ppj/2019.19.e589
   Kim JH, 2015, GYNECOL ONCOL, V136, P453, DOI 10.1016/j.ygyno.2015.01.524
   Kim SK, 2005, EXP NEUROL, V195, P430, DOI 10.1016/j.expneurol.2005.06.018
   Lam GY, 2010, SEMIN IMMUNOPATHOL, V32, P415, DOI 10.1007/s00281-010-0221-0
   Lee MS, 2011, CHIN J INTEGR MED, V17, P187, DOI 10.1007/s11655-011-0665-7
   Li P, 2006, AM J PHYSIOL-HEART C, V290, pH2535, DOI 10.1152/ajpheart.00972.2005
   Lujan HL, 2007, AM J PHYSIOL-HEART C, V292, pH2550, DOI 10.1152/ajpheart.00979.2006
   McDonald JL, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/591796
   Miao H, 2019, PHYSIOL RES, V68, P491, DOI 10.33549/physiolres.933939
   Miller Richard J, 2009, Handb Exp Pharmacol, P417, DOI 10.1007/978-3-540-79090-7_12
   MOI P, 1994, P NATL ACAD SCI USA, V91, P9926, DOI 10.1073/pnas.91.21.9926
   Pasetto LM, 2006, CRIT REV ONCOL HEMAT, V59, P159, DOI 10.1016/j.critrevonc.2006.01.001
   Pittler MH, 2008, CLIN J PAIN, V24, P731, DOI 10.1097/AJP.0b013e3181759231
   Portenoy RK, 2011, LANCET, V377, P2236, DOI 10.1016/S0140-6736(11)60236-5
   Salvemini D, 2011, FREE RADICAL BIO MED, V51, P951, DOI 10.1016/j.freeradbiomed.2011.01.026
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Sisignano M, 2014, NAT REV NEUROL, V10, P694, DOI 10.1038/nrneurol.2014.211
   Smith SB, 2004, LIFE SCI, V74, P2593, DOI 10.1016/j.lfs.2004.01.002
   Suzuki Y, 2012, SCI REP-UK, V2, DOI 10.1038/srep00896
   Tanabe Y, 2013, INT J CLIN ONCOL, V18, P132, DOI 10.1007/s10147-011-0352-x
   WORTHLEY EG, 1969, TOXICOL APPL PHARM, V15, P275, DOI 10.1016/0041-008X(69)90027-1
   Zhou W, 2006, J APPL PHYSIOL, V100, P926, DOI 10.1152/japplphysiol.01130.2005
NR 42
TC 38
Z9 44
U1 2
U2 13
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2019
VL 68
IS 3
BP 501
EP 510
DI 10.33549/physiolres.934084
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA IK8FT
UT WOS:000476830200015
PM 30904013
OA gold
DA 2026-01-16
ER

PT J
AU Nielsen, S
   Campbell, G
   Peacock, A
   Smith, K
   Bruno, R
   Hall, W
   Cohen, M
   Degenhardt, L
AF Nielsen, Suzanne
   Campbell, Gabrielle
   Peacock, Amy
   Smith, Kimberly
   Bruno, Raimondo
   Hall, Wayne
   Cohen, Milton
   Degenhardt, Louisa
TI Health service utilisation by people living with chronic non-cancer
   pain: findings from the Pain and Opioids IN Treatment (POINT) study
SO AUSTRALIAN HEALTH REVIEW
LA English
DT Article
DE acupuncture; barriers; chiropractor; complementary and alternative
   medicines
ID LOW-BACK-PAIN; EFFICACY; THERAPY; QUESTIONNAIRE; COMPLEMENTARY;
   METAANALYSIS; GUIDELINES; VETERANS; MEDICINE; BARRIERS
AB Objective. The aims of the present study were to describe the use, and barriers to the use, of non-medication pain therapies and to identify the demographic and clinical correlates of different non-opioid pain treatments.
   Methods. The study was performed on a cohort (n = 1514) of people prescribed pharmaceutical opioids for chronic noncancer pain (CNCP). Participants reported lifetime and past month use of healthcare services, mental and physical health, pain characteristics, current oral morphine equivalent daily doses and financial and access barriers to healthcare services.
   Results. Participants reported the use of non-opioid pain treatments, both before and after commencing opioid therapy. Services accessed most in the past month were complementary and alternative medicines (CAMs; 41%), physiotherapy (16%) and medical and/or pain specialists (15%). Higher opioid dose was associated with increased financial and access barriers to non-opioid treatment. Multivariate analyses indicated being younger, female and having private health insurance were the factors most commonly associated with accessing non-opioid treatments.
   Conclusions. Patients on long-term opioid therapy report using multiple types of pain treatments. High rates of CAM use are concerning given limited evidence of efficacy for some therapies and the low-income status of most people with CNCP. Financial and insurance barriers highlight the importance of considering how different types of treatments are paid for and subsidised.
C1 [Nielsen, Suzanne; Campbell, Gabrielle; Smith, Kimberly; Bruno, Raimondo; Degenhardt, Louisa] UNSW, Natl Drug & Alcohol Res Ctr, 22-32 King St, Randwick, NSW 2031, Australia.
   [Nielsen, Suzanne] South East Sydney Local Hlth Dist SESLHD Drug & A, 591-623 S Dowling St, Surry Hills, NSW 2010, Australia.
   [Peacock, Amy; Bruno, Raimondo] Univ Tasmania, Sch Med, Private Bag 30, Hobart, Tas 7001, Australia.
   [Hall, Wayne] Univ Queensland, Ctr Youth Subst Abuse Res, Brisbane, Qld 4072, Australia.
   [Cohen, Milton] UNSW Med, St Vincents Hosp, St Vincents Clin Sch, Level 5 deLacy Bldg,Victoria St, Darlinghurst, NSW 2010, Australia.
   [Degenhardt, Louisa] Univ Melbourne, Sch Populat & Global Hlth, Level 4,207 Bouverie St, Melbourne, Vic 3010, Australia.
C3 University of New South Wales Sydney; University of Tasmania; University
   of Queensland; St Vincent's Clinic; NSW Health; St Vincents Hospital
   Sydney; University of Melbourne
RP Nielsen, S (corresponding author), UNSW, Natl Drug & Alcohol Res Ctr, 22-32 King St, Randwick, NSW 2031, Australia.; Nielsen, S (corresponding author), South East Sydney Local Hlth Dist SESLHD Drug & A, 591-623 S Dowling St, Surry Hills, NSW 2010, Australia.
EM suzanne.nielsen@unsw.edu.au; g.campbell@unsw.edu.au;
   Amy.Peacock@utas.edu.au; kimberley.smith@unsw.edu.au;
   Raimondo.Bruno@utas.edu.au; w.hall@uq.edu.au; M.Cohen@unsw.edu.au;
   l.degenhardt@unsw.edu.au
RI Bruno, Raimondo/A-2381-2009; Hall, Wayne/A-3283-2008; Campbell,
   Gabrielle/B-1796-2015; Peacock, Amy/L-8523-2013; Nielsen,
   Suzanne/C-3256-2015; Degenhardt, Louisa/D-4515-2012
OI Bruno, Raimondo/0000-0001-6673-833X; Hall, Wayne/0000-0003-1984-0096;
   Peacock, Amy/0000-0002-5705-2026; Nielsen, Suzanne/0000-0001-5341-1055;
   Degenhardt, Louisa/0000-0002-8513-2218
FU Australian National Health and Medical Research Council (NHMRC)
   [1022522]; NHMRC [1013803, 1041472, 569738]; Australian Government under
   the Substance Misuse Prevention and Service Improvements Grant Fund;
   National Health and Medical Research Council (NHMRC) [569738, 1022522]
   Funding Source: National Health and Medical Research Council (NHMRC)
FX The authors acknowledge study investigators not involved in the direct
   writing of this paper: Michael Farrell, Nicholas Lintzeris, Richard
   Mattick, Fiona Shand and Briony Larance. Thanks to Jessica Belcher,
   Sarah Freckleton, Kimberley Smith, Ranira Moodley, Rachel
   Urquhart-Secord and Anika Martin for their contribution to data
   collection. Thanks also to the POINT advisory committee for their advice
   on the design and conduct of the study. This study was funded by the
   Australian National Health and Medical Research Council (NHMRC;
   #1022522). LD, BL, SN, WH and RPM are supported by NHMRC research
   fellowships (#1013803, #1041472, and #569738). The National Drug and
   Alcohol Research Centre at UNSW Australia is supported by funding from
   the Australian Government under the Substance Misuse Prevention and
   Service Improvements Grant Fund. The funders had no role in the
   preparation or decision to submit this manuscript.
CR ABS, 2006, STAT GEOGR, V1
   [Anonymous], 2003, The Cochrane Database of Systematic Reviews
   Barnes Patricia M, 2004, Adv Data, P1
   Bernardy K, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009796.pub2
   Campbell G, 2015, PAIN, V156, P231, DOI 10.1097/01.j.pain.0000460303.63948.8e
   Campbell G, 2014, BMC PHARMACOL TOXICO, V15, DOI 10.1186/2050-6511-15-17
   Chou R, 2009, J PAIN, V10, P113, DOI 10.1016/j.jpain.2008.10.008
   Cleeland C.S., 1991, BRIEF PAIN INVENTORY
   COUGHLAN GM, 1995, BRIT J CLIN PSYCHOL, V34, P471, DOI 10.1111/j.2044-8260.1995.tb01481.x
   Dworkin RH, 2005, PAIN, V113, P9, DOI 10.1016/j.pain.2004.09.012
   Eccleston C, 2009, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD007407.pub2, 10.1002/14651858.CD007407.pub3]
   Ezzo J, 2000, PAIN, V86, P217, DOI 10.1016/S0304-3959(99)00304-8
   Fleming Sara, 2007, BMC Complement Altern Med, V7, P15, DOI 10.1186/1472-6882-7-15
   FLOR H, 1992, PAIN, V49, P221, DOI 10.1016/0304-3959(92)90145-2
   Furlan AD, 2006, CAN MED ASSOC J, V174, P1589, DOI 10.1503/cmaj.051528
   Glajchen M, 2001, J Am Board Fam Pract, V14, P211
   Gómez C, 2015, GERONTOLOGY, V61, P301, DOI 10.1159/000365328
   Guzmán J, 2001, BMJ-BRIT MED J, V322, P1511, DOI 10.1136/bmj.322.7301.1511
   Haetzman M, 2003, FAM PRACT, V20, P147, DOI 10.1093/fampra/20.2.147
   Horne R, 1999, PSYCHOL HEALTH, V14, P1, DOI 10.1080/08870449908407311
   Hoy D, 2012, ARTHRITIS RHEUM-US, V64, P2028, DOI 10.1002/art.34347
   Hoy D, 2014, ANN RHEUM DIS, V73, P968, DOI 10.1136/annrheumdis-2013-204428
   Innovation New South Wales Agency for Clinical Innovation, 2014, COMPL ALT MED CAM
   Manchikanti L, 2012, PAIN PHYSICIAN, V15, pS67
   MBF Foundation, 2007, HIGH PRIC PAIN EC IM
   McEachrane-Gross F Patricia, 2006, BMC Complement Altern Med, V6, P34, DOI 10.1186/1472-6882-6-34
   Michna E, 2014, PAIN MED, V15, P79, DOI 10.1111/pme.12233
   Nicholas MK, 2008, PAIN, V134, P158, DOI 10.1016/j.pain.2007.04.007
   Nicholas MK, 2007, EUR J PAIN, V11, P153, DOI 10.1016/j.ejpain.2005.12.008
   Nielsen S, 2014, 329 UNSW AUSTR NAT D
   Noble M, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006605.pub2
   Open Mind Initiative, 2006, J Pain Palliat Care Pharmacother, V20, P79, DOI 10.1300/J354v20n03_17
   Sanderson K, 2002, AUST NZ J PUBL HEAL, V26, P343, DOI 10.1111/j.1467-842X.2002.tb00182.x
   Simmonds MJ, 2015, PAIN MED, V16, P726, DOI 10.1111/pme.12626
   Slaunwhite AK, 2015, COMMUNITY MENT HLT J, V51, P621, DOI 10.1007/s10597-014-9814-8
   Sullivan MD, 2010, PAIN, V149, P345, DOI 10.1016/j.pain.2010.02.037
   Therapeutic Goods Administration, 2013, STAND UN SCHED MED P
   Thomas KJ, 2001, COMPLEMENT THER MED, V9, P2, DOI 10.1054/ctim.2000.0407
   van Tulder M, 2000, SPINE, V25, P2784, DOI 10.1097/00007632-200011010-00011
   Vos T, 2012, LANCET, V380, P2163, DOI 10.1016/S0140-6736(12)61729-2
   Ware J.E., 1995, SF 12 SCORE SF 12 PH
   Xue CCL, 2007, J ALTERN COMPLEM MED, V13, P643, DOI 10.1089/acm.2006.6355
   Zedler B, 2014, PAIN MED, V15, P1911, DOI 10.1111/pme.12480
NR 43
TC 10
Z9 13
U1 0
U2 9
PU CSIRO PUBLISHING
PI CLAYTON
PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC
   3168, AUSTRALIA
SN 0156-5788
EI 1449-8944
J9 AUST HEALTH REV
JI Aust. Health Rev.
PY 2016
VL 40
IS 5
BP 490
EP 499
DI 10.1071/AH15047
PG 10
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA DZ6YB
UT WOS:000386007600003
PM 26599263
OA Bronze
DA 2026-01-16
ER

PT J
AU Nie, HM
   Liu, BY
   Yin, CY
   Dong, ZS
   Pan, YS
   Li, PY
   Hu, QM
   Wang, J
   Tai, Y
   Shao, XM
   Tian, GH
   Wang, C
   Fang, JQ
   Liu, BY
AF Nie, Huimin
   Liu, Boyu
   Yin, Chengyu
   Dong, Zishan
   Pan, Yushuang
   Li, Peiyi
   Hu, Qimiao
   Wang, Jie
   Tai, Yan
   Shao, Xiaomei
   Tian, Guihua
   Wang, Chuan
   Fang, Jianqiao
   Liu, Boyi
TI Neuronal Reg3β/macrophage TNF-α-mediated positive feedback signaling
   contributes to pain chronicity in a rat model of CRPS-I
SO SCIENCE ADVANCES
LA English
DT Article
ID COMPLEX REGIONAL PAIN; TUMOR-NECROSIS-FACTOR; SENSORY NEURONS; MOUSE
   MODEL; TYROSINE KINASE; SODIUM-CHANNELS; DRG NEURONS; MACROPHAGES;
   EXPRESSION; ELECTROACUPUNCTURE
AB Complex regional pain syndrome type I (CRPS-I) develops after an initial injury. It causes prolonged pain that persists beyond the usual expected time for tissue healing. Mechanisms underlying pain chronicity of CRPS-I remain unknown. Here, we identified the presence of long-lasting infiltration of macrophages in local dorsal root ganglia (DRG) of a rat model of CRPS-I. We demonstrate that regenerating islet-derived 3 beta (Reg3 beta) is specifically produced by DRG neurons upon model establishment and functions as an important signaling molecule to drive proinflammatory macrophage infiltration in local DRG. Infiltrated macrophages produce TNF-alpha, which causes hyperexcitability of nociceptive DRG neurons and reciprocally promotes Reg3 beta overexpression and secretion from DRG neurons to recruit more macrophages. Our work reveals a positive feedback signaling conveyed by neuronal Reg3 beta/macrophage TNF-alpha that contributes to neuroinflammation in DRG, resulting in persistent pain in a rat model of CRPS-I. This finding provides insights into the neuroimmune interaction in local DRG that contributes to pain chronicity of CRPS-I.
C1 [Nie, Huimin; Liu, Boyu; Yin, Chengyu; Pan, Yushuang; Li, Peiyi; Hu, Qimiao; Shao, Xiaomei; Fang, Jianqiao; Liu, Boyi] Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou, Peoples R China.
   [Yin, Chengyu] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Integrated Tradit Chinese & Western Med, Wuhan, Peoples R China.
   [Dong, Zishan] Hebei Med Univ, Dept Pathophysiol, Hebei Key Lab Crit Dis Mech & Intervent, Shijiazhuang, Peoples R China.
   [Wang, Jie] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Rehabil Tradit Chinese Med, Hangzhou, Peoples R China.
   [Tai, Yan] Zhejiang Chinese Med Univ, Acad Chinese Med Sci, Hangzhou, Peoples R China.
   [Tian, Guihua] Capital Med Univ, Beijing Friendship Hosp, Beijing, Peoples R China.
   [Wang, Chuan] Hebei Med Univ, Dept Pharmacol, Key Lab Neural & Vasc Biol, Minist Educ, Shijiazhuang, Peoples R China.
   [Wang, Chuan] Hebei Univ, Coll Pharmaceut Sci, Baoding, Peoples R China.
C3 Zhejiang Chinese Medical University; Huazhong University of Science &
   Technology; Hebei Medical University; Zhejiang University; Zhejiang
   Chinese Medical University; Capital Medical University; Hebei Medical
   University; Hebei University
RP Fang, JQ; Liu, BY (corresponding author), Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou, Peoples R China.; Wang, C (corresponding author), Hebei Med Univ, Dept Pharmacol, Key Lab Neural & Vasc Biol, Minist Educ, Shijiazhuang, Peoples R China.; Wang, C (corresponding author), Hebei Univ, Coll Pharmaceut Sci, Baoding, Peoples R China.
EM wangchuan@hebmu.edu.cn; fangjianqiao7532@163.com; boyi.liu@foxmail.com
RI Hu, qimiao/NYT-1144-2025; Tian, Guihua/AGM-8110-2022; Yin,
   Chengyu/NLN-8501-2025
OI Dong, zishan/0009-0009-5635-4768; Nie, Huimin/0000-0002-6327-5613; Wang,
   Chuan/0000-0003-3144-7094; Jie, Wang/0000-0003-3267-8556; Yin,
   Chengyu/0000-0001-5655-6292; pan, yushuang/0000-0002-6138-2474; Liu,
   Boyu/0000-0002-8801-8760
FU National Natural Science Foundation of China [82474625, 82305368,
   82305369, 81770407, 82105014]; Zhejiang Provincial Natural Science
   [LZ23H270001]; Natural Science Foundation of Hebei Province
   [H2024206491]; National High Level Traditional Chinese Medicine Hospital
   Clinical Research Funding [DZM-XZYY-23001]
FX This work was supported by the National Natural Science Foundation of
   China (82474625 to Boyi Liu), the Zhejiang Provincial Natural Science
   Funds (LZ23H270001 to Boyi Liu), the National Natural Science Foundation
   of China (82305368 to J.W., 82305369 to Boyu Liu, 81770407 to C.W., and
   82105014 to Q.H.), the Natural Science Foundation of Hebei Province (no.
   H2024206491 to C.W.), and the National High Level Traditional Chinese
   Medicine Hospital Clinical Research Funding (DZM-XZYY-23001 to G.T.).
CR Averill S, 2002, J NEUROSCI, V22, P7493
   Birklein F, 2018, NAT REV NEUROL, V14, P272, DOI 10.1038/nrneurol.2018.20
   Caceres AI, 2017, BRIT J PHARMACOL, V174, P867, DOI 10.1111/bph.13760
   Caxaria S, 2023, P NATL ACAD SCI USA, V120, DOI 10.1073/pnas.2211631120
   Chakrabarti S, 2020, ARTHRITIS RHEUMATOL, V72, P1749, DOI 10.1002/art.41314
   Chan KY, 2017, NAT NEUROSCI, V20, P1172, DOI 10.1038/nn.4593
   CHAPLAN SR, 1994, J NEUROSCI METH, V53, P55, DOI 10.1016/0165-0270(94)90144-9
   Chen L, 2025, SCI ADV, V11, DOI [10.1126/sciadv.adu2159, 10.1126/sciadv.adu2159]
   Chen Ouyang, 2023, Med Rev (2021), V3, P381, DOI [10.1515/mr-2023-0034, 10.1515/mr-2023-0034]
   Chen O, 2020, CURR OPIN NEUROBIOL, V62, P17, DOI 10.1016/j.conb.2019.11.006
   Chen RX, 2021, J NEUROINFLAMM, V18, DOI 10.1186/s12974-021-02131-0
   Chen RX, 2020, J NEUROINFLAMM, V17, DOI 10.1186/s12974-020-01834-0
   Chen SF, 2018, BIOINFORMATICS, V34, P884, DOI 10.1093/bioinformatics/bty560
   Chen W, 2018, ANAL BIOCHEM, V561, P59, DOI 10.1016/j.ab.2018.09.002
   Coderre TJ, 2004, PAIN, V112, P94, DOI 10.1016/j.pain.2004.08.001
   Cruceriu D, 2020, CELL ONCOL, V43, P1, DOI 10.1007/s13402-019-00489-1
   Dawes JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093338
   De Logu F, 2020, BRAIN BEHAV IMMUN, V88, P535, DOI 10.1016/j.bbi.2020.04.037
   Dirckx M, 2013, PAIN PRACT, V13, P633, DOI 10.1111/papr.12078
   DIXON WJ, 1980, ANNU REV PHARMACOL, V20, P441, DOI 10.1146/annurev.pa.20.040180.002301
   Eisenberg E, 2013, PAIN PRACT, V13, P649, DOI 10.1111/papr.12070
   Fassio A, 2022, RHEUMATOLOGY, V61, P3534, DOI 10.1093/rheumatology/keac060
   Gao Yong-Jing, 2009, Open Pain J, V2, P11
   Guimares RM, 2023, ELIFE, V12, DOI 10.7554/eLife.78515
   Haberberger RV, 2023, CELL TISSUE RES, V393, P17, DOI 10.1007/s00441-023-03770-w
   He SQ, 2010, MOL PAIN, V6, DOI 10.1186/1744-8069-6-23
   Hensellek S, 2007, MOL CELL NEUROSCI, V36, P381, DOI 10.1016/j.mcn.2007.07.010
   Hu QM, 2020, J PAIN, V21, P1060, DOI 10.1016/j.jpain.2020.01.007
   Hu QM, 2020, JOVE-J VIS EXP, DOI 10.3791/60562
   Hu QM, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00453
   Ino Y, 2023, J NEUROINFLAMM, V20, DOI 10.1186/s12974-023-02882-y
   Ji RR, 2014, NAT REV DRUG DISCOV, V13, P533, DOI 10.1038/nrd4334
   Jin XC, 2006, J NEUROSCI, V26, P246, DOI 10.1523/JNEUROSCI.3858-05.2006
   Jin Y, 2021, J INFLAMM RES, V14, P2841, DOI 10.2147/JIR.S315774
   Kaminow B., bioRxiv, DOI DOI 10.1101/2021.05.05.442755
   Li JY, 2020, J NEUROSCI, V40, P297, DOI 10.1523/JNEUROSCI.1414-19.2019
   Li XJ, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/8035109
   Li YZ, 2004, J NEUROSCI, V24, P9623, DOI 10.1523/JNEUROSCI.2392-04.2004
   Liu BY, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165200
   Liu BY, 2016, P NATL ACAD SCI USA, V113, pE7572, DOI 10.1073/pnas.1606608113
   Liu BY, 2010, J CLIN INVEST, V120, P1240, DOI 10.1172/JCI41084
   Liu BY, 2022, CELL MOL BIOL LETT, V27, DOI 10.1186/s11658-022-00316-w
   Liu F, 2023, ADV SCI, V10, DOI 10.1002/advs.202205397
   Liu F, 2020, ARTHRITIS RHEUMATOL, V72, P1668, DOI 10.1002/art.41386
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Lörchner H, 2018, CARDIOVASC RES, V114, P1667, DOI 10.1093/cvr/cvy126
   Lörchner H, 2015, NAT MED, V21, P353, DOI 10.1038/nm.3816
   Lopez-Santiago LF, 2006, J NEUROSCI, V26, P7984, DOI 10.1523/JNEUROSCI.2211-06.2006
   Marinus J, 2011, LANCET NEUROL, V10, P637, DOI 10.1016/S1474-4422(11)70106-5
   Marvaldi L, 2020, SCIENCE, V369, P842, DOI 10.1126/science.aaz5875
   Miclescu AA, 2013, PAIN PRACT, V13, P641, DOI 10.1111/papr.12027
   Ott S, 2018, J PAIN, V19, P599, DOI 10.1016/j.jpain.2018.01.004
   Pu SF, 2023, NEUROSCI BULL, V39, P177, DOI 10.1007/s12264-022-00910-0
   Raoof R, 2021, J NEUROSCI, V41, P8249, DOI 10.1523/JNEUROSCI.1787-20.2021
   Ren JH, 2024, ACUPUNCT HERB MED, V4, P525, DOI 10.1097/HM9.0000000000000140
   Sharma A, 2009, REGION ANESTH PAIN M, V34, P110, DOI 10.1097/AAP.0b013e3181958f90
   Silva JR, 2017, J NEUROSCI, V37, P6408, DOI 10.1523/JNEUROSCI.2233-16.2017
   Sun C, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22137196
   Takada Y, 2004, J IMMUNOL, V173, P1066, DOI 10.4049/jimmunol.173.2.1066
   Taylor SS, 2021, PAIN THER, V10, P875, DOI 10.1007/s40122-021-00279-4
   Uckun FM, 2010, P NATL ACAD SCI USA, V107, P2902, DOI 10.1073/pnas.0909086107
   Üçeyler N, 2007, PAIN, V132, P195, DOI 10.1016/j.pain.2007.07.031
   Wang J, 2023, J NEUROINFLAMM, V20, DOI 10.1186/s12974-023-02778-x
   Wang J, 2020, FRONT NEUROL, V11, DOI 10.3389/fneur.2020.580997
   Wang Q, 2021, J ADV RES, V31, P97, DOI 10.1016/j.jare.2020.12.009
   Wei HN, 2023, CHIN MED-UK, V18, DOI 10.1186/s13020-023-00800-1
   Xu RY, 2024, THERANOSTICS, V14, P5281, DOI 10.7150/thno.97856
   Yin CY, 2024, THERANOSTICS, V14, P3082, DOI 10.7150/thno.95611
   Yin CY, 2024, NAT COMMUN, V15, DOI 10.1038/s41467-024-47640-7
   Yin CY, 2020, THERANOSTICS, V10, P12189, DOI 10.7150/thno.48028
   Yin CY, 2020, BRIT J PHARMACOL, V177, P2042, DOI 10.1111/bph.14967
   Yin CY, 2019, J PAIN RES, V12, P1201, DOI 10.2147/JPR.S188758
   Yu XB, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-13839-2
   Zhang L, 2021, BRAIN BEHAV IMMUN, V91, P556, DOI 10.1016/j.bbi.2020.11.015
   Zuo WJ, 2023, CELL MOL BIOL LETT, V28, DOI 10.1186/s11658-023-00491-4
NR 75
TC 1
Z9 1
U1 15
U2 15
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
EI 2375-2548
J9 SCI ADV
JI Sci. Adv.
PD AUG 1
PY 2025
VL 11
IS 31
AR eadu4270
DI 10.1126/sciadv.adu4270
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 5RE8Q
UT WOS:001542395300015
PM 40749060
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Oberoi, DV
   Longo, CJ
   Reed, EN
   Landmann, J
   Piedalue, KAL
   Carlson, LE
AF Oberoi, Devesh V.
   Longo, Christopher J.
   Reed, Erica Nicole
   Landmann, Jessa
   Piedalue, Katherine-Ann Laura
   Carlson, Linda E.
TI Cost-Utility of Group Versus Individual Acupuncture for Cancer-Related
   Pain Using Quality-Adjusted Life Years in a Noninferiority Trial
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE oncology; acupuncture; group acupuncture; cost&#8211; utility analysis;
   quality of life; out-of-pocket costs for cancer care
AB Introduction: Individual acupuncture (AP) is the gold standard method of AP delivery for cancer-related pain; however, costs can be prohibitive. Group AP allows four to six patients to be treated in a single session. This study sought to examine the cost-utility of group AP compared with individual AP from a patient perspective.
   Materials and Methods: Effectiveness and cost data from a noninferiority randomized trial of group versus individual AP for cancer-related pain were used. In the trial, 74 patients were randomly assigned to individual or group AP treatments twice per week for 6 weeks. The EuroQol five-dimension five level questionnaire (EQ-5D-5L) was used to assess health-related quality of life, and the EQ-5D Utility Index was used as a composite measure constituted of five domains (mobility, self-care, usual activities, anxiety-depression, and pain-discomfort). Linear mixed models were used to compare the change in EQ-5D-5L states pre-post intervention between the two arms. A cost-utility analysis was performed in terms of the incremental costs per additional quality-adjusted life year (QALY) gained.
   Results: Group AP participants experienced more significant relief in the pain-discomfort subscale of the EQ-5D-5L measure compared with individual AP participants (group x time, F = 6.18; p = 0.02). The effect size on pain-discomfort for group AP (d = 0.80) was higher than that of individual AP (d = 0.34). There were no significant differences between the two study arms for other subscales of the EQ-5D-5L over time. QALYs at 6 weeks were slightly higher for group AP (0.020) compared with individual AP (0.007) leading to an incremental QALY gained by the group arm of 0.013, but this difference was not statistically significant (p = 0.07). The cost of delivering AP treatment for the group arm over 6 weeks ($201.25) was nearly half of the individual arm ($400).
   Conclusions: Group AP was superior to individual AP in cancer patients. These findings have implications for the use of group AP in low-resource settings and in health care systems where AP for cancer patients is not covered by public health insurance.
   ClinicalTrials.gov (NCT03641222). Registered July 10, 2018-Retrospectively registered, https://clinicaltrials.gov/ct2/show/study/NCT03641222
C1 [Oberoi, Devesh V.; Reed, Erica Nicole; Piedalue, Katherine-Ann Laura; Carlson, Linda E.] Univ Calgary, Cumming Sch Med, Div Psychosocial Oncol, Dept Oncol, Calgary, AB, Canada.
   [Oberoi, Devesh V.; Piedalue, Katherine-Ann Laura; Carlson, Linda E.] Holy Cross Ctr Phase I, Dept Psychosocial Oncol, Canc Control Alberta, 2202 2nd St SW, Calgary, AB T2S 3C1, Canada.
   [Longo, Christopher J.] McMaster Univ, DeGroote Sch Business, Hamilton, ON, Canada.
   [Landmann, Jessa] Vive Integrat Hlth Grp, Calgary, AB, Canada.
C3 University of Calgary; McMaster University
RP Carlson, LE (corresponding author), Holy Cross Ctr Phase I, Dept Psychosocial Oncol, Canc Control Alberta, 2202 2nd St SW, Calgary, AB T2S 3C1, Canada.
EM lcarlso@ucalgary.ca
RI Oberoi, Devesh/H-8299-2016; Carlson, Linda E/AEN-5702-2022
OI Carlson, Linda E/0000-0002-4411-2085
FU Enbridge Research Chair in Psychosocial Oncology - Canadian Cancer
   Society Alberta/NWT Division; Alberta Cancer Foundation
FX This study was supported by the Enbridge Research Chair in Psychosocial
   Oncology, co-funded by the Canadian Cancer Society Alberta/NWT Division
   and the Alberta Cancer Foundation, held by Dr. Carlson. The funding body
   had no role in the design of the study and collection, analysis, and
   interpretation of data and in writing the article.
CR Anderson KO, 2002, CANCER, V94, P2295, DOI 10.1002/cncr.10414
   Bertram MY, 2016, B WORLD HEALTH ORGAN, V94, P925, DOI 10.2471/BLT.15.164418
   Blom M, 1996, ORAL ONCOL, V32B, P182
   Chao MT, 2012, J ALTERN COMPLEM MED, V18, P561, DOI 10.1089/acm.2011.0128
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Chuang E, 2018, J ALTERN COMPLEM MED, V24, P336, DOI 10.1089/acm.2017.0262
   CLEELAND CS, 1994, NEW ENGL J MED, V330, P592, DOI 10.1056/NEJM199403033300902
   Craig BM, 2010, PAIN MED, V11, P240, DOI 10.1111/j.1526-4637.2009.00762.x
   Cui Y, 2004, BREAST CANCER RES TR, V85, P263, DOI 10.1023/B:BREA.0000025422.26148.8d
   Deng G, 2005, CA-CANCER J CLIN, V55, P109, DOI 10.3322/canjclin.55.2.109
   DUNDEE JW, 1989, J ROY SOC MED, V82, P268, DOI 10.1177/014107688908200508
   Feelemyer JP, 2014, DRUG ALCOHOL DEPEN, V134, P251, DOI 10.1016/j.drugalcdep.2013.10.011
   Fisch MJ, 2012, J CLIN ONCOL, V30, P1980, DOI 10.1200/JCO.2011.39.2381
   Goudas LC, 2005, CANCER INVEST, V23, P182, DOI 10.1081/CNV-200050482
   Green CR, 2011, CANCER-AM CANCER SOC, V117, P1994, DOI 10.1002/cncr.25761
   Green CR, 2003, J PAIN, V4, P29, DOI 10.1054/jpai.2003.5
   Gueorguieva R, 2004, ARCH GEN PSYCHIAT, V61, P310, DOI 10.1001/archpsyc.61.3.310
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Herbert MS, 2017, J PAIN, V18, P200, DOI 10.1016/j.jpain.2016.10.014
   Herdman M, 2011, QUAL LIFE RES, V20, P1727, DOI 10.1007/s11136-011-9903-x
   Johnstone PAS, 2001, INT J RADIAT ONCOL, V50, P353, DOI 10.1016/S0360-3016(00)01530-3
   Julious SA, 2004, STAT MED, V23, P1921, DOI 10.1002/sim.1783
   Lafferty WE, 2004, CANCER-AM CANCER SOC, V100, P1522, DOI 10.1002/cncr.20105
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   McKee MD, 2020, J GEN INTERN MED, V35, P1227, DOI 10.1007/s11606-019-05583-6
   Morris KT, 2000, AM J SURG, V179, P407, DOI 10.1016/S0002-9610(00)00358-5
   PALEY CA, 2015, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD007753.PUB3
   Ramsey S, 2013, HEALTH AFFAIR, V32, P1143, DOI 10.1377/hlthaff.2012.1263
   Reed EN, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/7209548
   Roscoe JA, 2003, J PAIN SYMPTOM MANAG, V26, P731, DOI 10.1016/S0885-3924(03)00254-9
   Running A, 2012, CURR PAIN HEADACHE R, V16, P325, DOI 10.1007/s11916-012-0275-x
   Sculpher MJ, 2006, HEALTH ECON, V15, P677, DOI 10.1002/hec.1093
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   Swarm RA, 2019, J NATL COMPR CANC NE, V17, P977, DOI 10.6004/jnccn.2019.0038
   Tippens KM, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-293
   Vickers AJ, 2004, J CLIN ONCOL, V22, P1731, DOI 10.1200/JCO.2004.04.102
   Vinjamury SP, 2013, CHIN MED-UK, V8, DOI 10.1186/1749-8546-8-15
   Winkelmayer WC, 2003, CONTEMP CARDIOL, P329
   Wong RKW, 2003, INT J RADIAT ONCOL, V57, P472, DOI 10.1016/S0360-3016(03)00572-8
   Zhang Y., 2007, Evidence-based complementary and alternative medicine, V2012, P8, DOI DOI 10.1155/2012/710750
NR 40
TC 5
Z9 8
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD MAY 1
PY 2021
VL 27
IS 5
BP 390
EP 397
DI 10.1089/acm.2020.0386
EA APR 2021
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA SD2FV
UT WOS:000644564100001
PM 33904784
DA 2026-01-16
ER

PT J
AU Faruqi, F
   Ruddy, KJ
   Blackmon, S
AF Faruqi, Fahad
   Ruddy, Kathryn J.
   Blackmon, Shanda
TI Integrative Approaches to Minimize Peri-operative Symptoms
SO CURRENT ONCOLOGY REPORTS
LA English
DT Review
DE Integrative medicine; Acupuncture; Guided imagery; Loving-kindness
   meditation; Peri-operative symptoms; Post-thoracotomy pain syndrome;
   PTPS; Complementary medicine; CAM
ID POSTTHORACOTOMY PAIN SYNDROME; PULMONARY COMPLICATIONS; POSTOPERATIVE
   PAIN; THORACOSCOPIC SURGERY; PARAVERTEBRAL BLOCK; ANALGESIA; MANAGEMENT;
   RESECTION; EFFICACY; REQUIREMENTS
AB Purpose of Review Cancer patients who require surgery often experience peri-operative symptoms, including nausea, anxiety, and pain, which can significantly impair quality of life. Here, we review the evidence for using integrative approaches to manage these peri-operative symptoms.
   Recent Findings Conventional peri-operative pharmacologic interventions, such as opiates for pain control, can lead to adverse effects such as respiratory depression, prolonged hospital course, and long-term dependence. Integrative medicine, also known as complementary and alternative medicine (CAM), has been explored as way to reduce peri-operative symptoms. Acupuncture, guided imagery, and loving-kindness meditation have all shown potential efficacy in reducing both peri-operative pain and anxiety in retrospective studies and small randomized controlled trials.
   Summary Integrative medicine techniques, such as acupuncture, are a promising approach to control peri-operative symptoms without the associated adverse effects of more conventional pharmacologic interventions.
C1 [Faruqi, Fahad; Ruddy, Kathryn J.; Blackmon, Shanda] Mayo Clin, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Faruqi, F (corresponding author), Mayo Clin, Rochester, MN 55905 USA.
EM faruqi.fahad@mayo.edu
CR Attias S, 2016, J CLIN ANESTH, V29, P54, DOI 10.1016/j.jclinane.2015.10.017
   Batchelor TJP, 2019, EUR J CARDIO-THORAC, V55, P91, DOI 10.1093/ejcts/ezy301
   Bialka S, 2018, J THORAC DIS, V10, DOI 10.21037/jtd.2018.07.88
   Brunelli A, 2014, ANN THORAC SURG, V98, P238, DOI 10.1016/j.athoracsur.2014.04.029
   Bucx MJL, 2016, J CLIN ANESTH, V33, P135, DOI 10.1016/j.jclinane.2016.03.025
   Canet J, 2010, ANESTHESIOLOGY, V113, P1338, DOI 10.1097/ALN.0b013e3181fc6e0a
   Carpenter JJ, 2017, J HOLIST NURS, V35, P342, DOI 10.1177/0898010116675462
   Chen JB, 2020, INT J SURG, V73, P57, DOI 10.1016/j.ijsu.2019.10.036
   Fernandez MI, 2005, EUR J CARDIO-THORAC, V27, P671, DOI 10.1016/j.ejcts.2004.12.045
   Fibla JJ, 2011, EUR J CARDIO-THORAC, V40, P907, DOI 10.1016/j.ejcts.2010.12.043
   Gan TJ, 2017, J PAIN RES, V10, P2287, DOI 10.2147/JPR.S144066
   Garland EL, 2020, JAMA INTERN MED, V180, P91, DOI 10.1001/jamainternmed.2019.4917
   Gillis C, 2014, ANESTHESIOLOGY, V121, P937, DOI 10.1097/ALN.0000000000000393
   Granger C, 2017, PREOPERATIVE EXERCIS
   Gustafsson UO, 2019, WORLD J SURG, V43, P659, DOI 10.1007/s00268-018-4844-y
   Hah JM, 2017, ANESTH ANALG, V125, P1733, DOI 10.1213/ANE.0000000000002458
   Hamada K, 2019, LUNG CANCER, V128, P47, DOI 10.1016/j.lungcan.2018.12.013
   Hetmann F, 2017, J PAIN RES, V10, P663, DOI 10.2147/JPR.S126639
   Hill SE, 2006, ANESTHESIOLOGY, V104, P1047, DOI 10.1097/00000542-200605000-00022
   Hirai K, 2019, J THORAC DIS, V11, P3896, DOI 10.21037/jtd.2019.09.07
   Kaplowitz J, 2012, J CARDIOTHOR VASC AN, V26, P312, DOI 10.1053/j.jvca.2011.04.010
   Karmakar Manoj K, 2004, Thorac Surg Clin, V14, P345, DOI 10.1016/S1547-4127(04)00022-2
   Kaya FN, 2006, J CARDIOTHOR VASC AN, V20, P639, DOI 10.1053/j.jvca.2006.03.022
   Kim JA, 2009, J KOREAN MED SCI, V24, P930, DOI 10.3346/jkms.2009.24.5.930
   Maeda K, 2016, GERIATR GERONTOL INT, V16, P550, DOI 10.1111/ggi.12505
   Mesbah A, 2016, BJA EDUC, V16, P1, DOI 10.1093/bjaceaccp/mkv005
   Metin SK, 2017, ANN THORAC SURG, V103, P1109, DOI 10.1016/j.athoracsur.2016.09.031
   Nelson DB, 2019, J THORAC CARDIOV SUR, V158, P279, DOI 10.1016/j.jtcvs.2019.03.009
   Palmer JB, 2015, J CLIN ONCOL, V33, P3162, DOI 10.1200/JCO.2014.59.6049
   Qiu Robert, 2018, Rom J Anaesth Intensive Care, V25, P43, DOI [10.21454/rjaic.7518.251.gab, 10.21454/rjaic.7518.251.gab]
   Rawal N, 2016, EUR J ANAESTH, V33, P160, DOI 10.1097/EJA.0000000000000366
   Reyad RM, 2020, EUR J PAIN, V24, P159, DOI 10.1002/ejp.1473
   Saito H, 2017, THORAC CANCER, V8, P451, DOI 10.1111/1759-7714.12466
   Schiff E, 2019, COMPLEMENT THER MED, V44, P51, DOI 10.1016/j.ctim.2019.03.003
   Vogt A, 2005, BRIT J ANAESTH, V95, P816, DOI 10.1093/bja/aei250
   Wheeler M, 2002, J PAIN, V3, P159, DOI 10.1054/jpai.2002.123652
   Williams JB, 2013, AM J CARDIOL, V111, P137, DOI 10.1016/j.amjcard.2012.08.060
   Wren AA, 2019, SUPPORT CARE CANCER, V27, P3583, DOI 10.1007/s00520-019-4657-z
   Wu MS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150367
   Wunsch H, 2016, JAMA-J AM MED ASSOC, V315, P1654, DOI 10.1001/jama.2016.0130
   Yang CK, 2015, J SURG RES, V198, P441, DOI 10.1016/j.jss.2015.03.028
   Yasin J, 2020, DIAGN INTERV RADIOL, V26, P53, DOI 10.5152/dir.2019.19179
   Yoshioka Masakazu, 2006, Ann Thorac Cardiovasc Surg, V12, P313
   Zhang RY, 2015, ANN THORAC SURG, V99, P1761, DOI 10.1016/j.athoracsur.2015.01.030
NR 44
TC 1
Z9 3
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3790
EI 1534-6269
J9 CURR ONCOL REP
JI Curr. Oncol. Rep.
PD JUN
PY 2021
VL 23
IS 6
AR 73
DI 10.1007/s11912-021-01051-9
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA RU0EA
UT WOS:000644823900001
PM 33907909
DA 2026-01-16
ER

PT J
AU Wang, JL
   Zhang, QH
   Deng, YW
   Deng, G
   Huang, FH
   Zhou, YD
   Jia, MY
   Yi, HR
AF Wang, Jinlong
   Zhang, Quanhui
   Deng, Yongwen
   Deng, Gen
   Huang, Feihong
   Zhou, Yiduo
   Jia, Mingyan
   Yi, Haoran
TI Efficacy and safety of heat-sensitive moxibustion in the treatment of
   ulcerative colitis A protocol for a systematic review and meta-analysis
SO MEDICINE
LA English
DT Review
DE heat-sensitive moxibustion; systematic review and meta Analysis;
   ulcerative colitis
AB Background: Ulcerative colitis (UC) is a chronic nonspecific intestinal inflammatory disease with unclear etiology occurring in the colonic mucosa. Its clinical manifestations are characterized by recurrent abdominal pain, diarrhea, mucous pus, and blood stool. The severity of the disease varies, and itis characterized by a high recurrence rate. Because of its long course of disease, easy to relapse, protracted and difficult to recover, seriously affect the quality of life, increase the economic burden of patients and society, and even the risk of developing cancer, it has become one of the hot issues of general concern in the medical field. Heat-sensitive moxibustion therapy has shown strong advantages in the treatment of UC, and the curative effect is accurate. therefore, this paper will carry out a systematic evaluation and meta analysis of the efficacy and safety of heat-sensitive moxibustion in the treatment of UC. Methods: We will be searching 8 electronic databases, including PubMed, Embase, Web of Science, Cochrane Library, the China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, Wanfang Database, and Chinese Biomedical Literature Database. We will search above electronic databases from the beginning to December 2020, without any language restriction. Clinical efficacy, including total effective rate or cure rate, clinical symptom integral (abdominal pain, diarrhea, purulent stool), and recurrence rate will be accepted as the primary outcomes. The changes of cytokine Hs-CRP, IL-6, TNF-alpha levels in serum, and improvement of colorectal mucosa will be used as secondary outcomes. RevMan 5.3 software will be used for statistical analysis. The result about the curative effect and safety of heat-sensitive moxibustion for UC will be presented as risk ratio for dichotomous data and mean differences with a 95% confidence interval for continuous data. Results: When this research program is completed, the relevant results can be obtained. Conclusions: The results of this study will provide reliable evidence for the efficacy and safety of heat-sensitive moxibustion in the treatment of UC. INPLASY Registration number: INPLASY20201101034.
C1 [Wang, Jinlong; Deng, Yongwen; Deng, Gen; Huang, Feihong; Zhou, Yiduo; Jia, Mingyan; Yi, Haoran] Jiangxi Univ Tradit Chinese Med, Coll Clin Med, Nanchang, Jiangxi, Peoples R China.
   [Zhang, Quanhui] Jiangxi Univ Tradit Chinese Med, Affiliated Hosp, Nanchang 330006, Jiangxi, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine; Jiangxi University
   of Traditional Chinese Medicine
RP Zhang, QH (corresponding author), Jiangxi Univ Tradit Chinese Med, Affiliated Hosp, Nanchang 330006, Jiangxi, Peoples R China.
EM 36791584@qq.com
OI deng, gen/0000-0003-2614-104X
FU Scientific Research Project of Jiangxi Health and Health Commission
   [2017A016]
FX This work was supported by grant from Scientific Research Project of
   Jiangxi Health and Health Commission (No.2018A124); Scientific Research
   Project of Jiangxi Health and Health Commission (No.2017A016).
CR Bi Tingting., 2019, CHIN FOLK THER, V27, P105
   Chen Ri-Xin, 2010, Zhen Ci Yan Jiu, V35, P311
   Chen Ri-xin, 2008, Zhongguo Zhen Jiu, V28, P44
   Guo BJ, 2017, ANN NY ACAD SCI, V1401, P37, DOI 10.1111/nyas.13414
   Lijiu, 2019, ANHUI MED, V23, P860
   Lu Liqun., 2017, SICHUAN TRADIT CHIN, V35, P95
   Lu Shuhong., 2013, JIANGXI TRADIT CHIN, V44, P46
   Lu Shuhong., 2016, BRIGHT CHIN MED, V31, P1604
   Ouyang Q, 2012, J DIGEST DIS, V13, P195, DOI 10.1111/j.1751-2980.2012.00579.x
   Xiang Guo, 2010, CHINESE FOLK THERAPY, V18, P12
   Zhang Juan., 2020, Liaon- ing J Tradit Chin Med, V47, P203
   Zhao Qingxi., 2015, J MED C QINGDAO U, V51, P486
   Zhu Yannan., 2019, CLIN RES TRADITIONAL, V11, P146
NR 13
TC 7
Z9 9
U1 1
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN 29
PY 2021
VL 100
IS 4
AR e24078
DI 10.1097/MD.0000000000024078
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PZ6FF
UT WOS:000612833500050
PM 33530201
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, GY
   Li, SQ
   Sun, LZ
   Lin, FG
   Wang, BG
AF Li, Guoyan
   Li, Shuqin
   Sun, Lizhi
   Lin, Fangcai
   Wang, Baoguo
TI A comparison study of immune-inflammatory response in electroacupuncture
   and transcutaneous electrical nerve stimulation for patients undergoing
   supratentorial craniotomy
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Transcutaneous electrical nerve stimulation (TENS); electroacupuncture
   (EA); immuno-inflammatory; supratentorial craniotomy
ID LOW-BACK-PAIN; RATS; RELEASE; BLOCK
AB Objective: The effect of transcutaneous electrical nerve stimulation (TENS) on immuno-inflammatory response was tested and the differences between electroacupuncture (EA) and TENS in immuno-inflammatory response in patients undergoing supratentorial craniotomy were explored. Methods: 51 patients received craniotomy were randomly divided into 3 groups: control (group C, n=18), EA (group A, n=19) and TENS (group T, n=14) groups. Blood samples were collected before anesthesia (TO) and 30 min (T1), 2 h (T2) and 4 h (T3) after induction of anesthesia to measure the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-8, IL-10, IgM, IgA and IgG. Results: No significant difference existed between group A and group T during craniotomy. IgM and IgA decreased significantly in group C compared with groups A and T at T2 and T3 time points. Compared with group C, there were significant differences in TNF-a, IgM and IgA levels at TO in groups A and T; no significant difference was found in the levels of IgG, IL-10 and IL-8. Conclusion: EA and TENS could reduce immunosuppression in patients undergoing supratentorial craniotomy and it has significance in choice of treatment in immunosuppressive therapy.
C1 [Li, Guoyan; Sun, Lizhi] North China Grid Co Ltd, Beijing Elect Power Hosp, Dept Anesthesiol, Beijing, Peoples R China.
   [Li, Shuqin] Beijing Tiantan Hosp, Dept Anesthesiol, Beijing, Peoples R China.
   [Lin, Fangcai] North China Grid Co Ltd, Beijing Elect Power Hosp, Dept Gen Surg, Beijing, Peoples R China.
   [Wang, Baoguo] Beijing Sanbo Brain Hosp, Dept Anesthesiol & Pain Management, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Wang, BG (corresponding author), Sanbo Brain Hosp, Dept Anesthesiol, 50 Xiang Shan Yi Ke Song, Beijing 100093, Peoples R China.
EM baoguowang77@126.com
RI Lin, Fan/GRX-5813-2022
FU state grid program of science and technology [SGHBOOO-AJJS1400182];
   National Key Basic Research Program on innovation and application study
   of combined acupuncture drug [2013CB531901]
FX This work was supported by the multidisciplinary study on chronic
   diseases in electric power system employees and the subprogram "the
   effect of different anesthetic methods on immuneinflammatory response in
   patients undergoing supratentorial craniotomy" (The state grid program
   of science and technology, SGHBOOO-AJJS1400182) and the National Key
   Basic Research Program on innovation and application study of combined
   acupuncture drug (2013CB531901).
CR Arai YC, 2012, EVID-BASED COMPL ALT
   Chen GY, 2010, NAT REV IMMUNOL, V10, P826, DOI 10.1038/nri2873
   Chu H, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-84
   DeSantana Josimari M, 2008, Curr Rheumatol Rep, V10, P492
   Ding LC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057477
   Fang JF, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-134
   Gu G, 2011, J INT MED RES, V39, P1783, DOI 10.1177/147323001103900521
   Keskin EA, 2012, GYNECOL OBSTET INVES, V74, P76, DOI 10.1159/000337720
   Khalil Z, 2000, J GERONTOL A-BIOL, V55, pB257, DOI 10.1093/gerona/55.6.B257
   Kita K, 2013, J NEUROENG REHABIL, V10, DOI 10.1186/1743-0003-10-55
   Kloth L C, 1996, Adv Wound Care, V9, P42
   Kutlu AK, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/361832
   Lan F, 2012, MINERVA ANESTESIOL, V78, P887
   Li GY, 2013, ACUPUNCT MED, V31, P51, DOI 10.1136/acupmed-2012-010254
   Liu SJ, 2011, ANESTH ANALG, V113, P572, DOI 10.1213/ANE.0b013e3182278237
   Pinosky ML, 1996, ANESTH ANALG, V83, P1256, DOI 10.1097/00000539-199612000-00022
   Sabino GS, 2008, J PAIN, V9, P157, DOI 10.1016/j.jpain.2007.09.003
   Sluka KA, 2006, ARCH PHYS MED REHAB, V87, P1137, DOI 10.1016/j.apmr.2006.04.023
   Stein C, 2013, BRAZ J PHYS THER, V17, P93, DOI 10.1590/S1413-35552012005000083
   Trinh K, 2007, SPINE, V32, P236, DOI 10.1097/01.brs.0000252100.61002.d4
   WANG JQ, 1992, INT J NEUROSCI, V65, P117, DOI 10.3109/00207459209003283
   Yokoyama M, 2001, ANESTH ANALG, V92, P463, DOI 10.1213/00000539-200102000-00035
   Zaniewska R, 2012, MED PR, V63, P295
   Zhang WT, 2003, NEUROREPORT, V14, P1591, DOI 10.1097/00001756-200308260-00010
NR 24
TC 1
Z9 4
U1 0
U2 6
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2015
VL 8
IS 1
BP 1156
EP 1161
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CB8RA
UT WOS:000349897200140
PM 25785107
DA 2026-01-16
ER

PT J
AU Zhou, J
   Fang, L
   Wu, WY
   He, F
   Zhang, XL
   Zhou, X
   Xiong, ZJ
AF Zhou, J.
   Fang, L.
   Wu, W. Y.
   He, F.
   Zhang, X. L.
   Zhou, X.
   Xiong, Z. J.
TI The effect of acupuncture on chemotherapy-associated gastrointestinal
   symptoms in gastric cancer
SO CURRENT ONCOLOGY
LA English
DT Article
DE Acupuncture; gastric cancer; chemotherapy; gastrointestinal symptoms;
   quality of life
ID QUALITY-OF-LIFE; CLINICAL-PRACTICE GUIDELINES; ADJUVANT CHEMOTHERAPY;
   PERSIAN VERSION; WHOQOL-100; TRIALS; THROMBOCYTOPENIA; METAANALYSIS;
   PREVENTION; THERAPY
AB Background Gastrointestinal (GI) symptoms are the most notable side effects of chemotherapeutic drugs; such symptoms are currently treated with drugs. In the present study, we investigated the effect of acupuncture on GI symptoms induced by chemotherapy in patients with advanced gastric cancer.
   Methods A cohort of 56 patients was randomly divided into an experimental group and a control group. All patients received combination chemotherapy with oxaliplatin-paclitaxel. Patients in the experimental group received 30 minutes of acupuncture therapy daily for 2 weeks. The frequency and duration of nausea, vomiting, abdominal pain, and diarrhea, the average days and costs of hospitalization, and quality-of-life scores were compared between the groups.
   Results Nausea was sustained for 32 +/- 5 minutes and 11 +/- 3 minutes daily in the control and experimental groups respectively (p < 0.05). On average, vomiting occurred 2 +/- 1 times daily in the experimental group and 4 +/- 1 times daily in the control group (p < 0.05). Abdominal pain persisted for 7 +/- 2 minutes and 16 +/- 5 minutes daily in the experimental and control groups respectively (p < 0.05). On average, diarrhea occurred 1 +/- 1 times daily in the experimental group and 3 +/- 1 times daily in the control group (p < 0.05). The average quality-of-life score was higher in the experimental group than in the control group (p < 0.05). No adverse events were observed for the patients receiving acupuncture.
   Conclusions Acupuncture, a safe technique, could significantly reduce GI symptoms induced by chemotherapy and enhance quality of life in patients with advanced gastric cancer.
C1 [Fang, L.; Wu, W. Y.; He, F.; Zhang, X. L.] Chengdu Med Coll, Dept Gastroenterol, Affiliated Hosp 1, 238 Baoguang Rd, Chengdu, Sichuan, Peoples R China.
   [Zhou, J.; Zhou, X.; Xiong, Z. J.] Chengdu Med Coll, Dept Chemotherapy, Sichuan Canc Hosp, Chengdu, Sichuan, Peoples R China.
C3 Chengdu Medical College; Chengdu Medical College
RP Fang, L (corresponding author), Chengdu Med Coll, Dept Gastroenterol, Affiliated Hosp 1, 238 Baoguang Rd, Chengdu, Sichuan, Peoples R China.
EM fangzjt521@163.com
FU Science and Technology Department of Sichuan Province [2011JYZ034,
   2016JY0115]; Health Department of Sichuan Province [120035]; Academy of
   Finland (AKA) [120035] Funding Source: Academy of Finland (AKA)
FX This study was financially supported by grants from the Science and
   Technology Department of Sichuan Province (2011JYZ034, 2016JY0115) and
   the Health Department of Sichuan Province (120035).
CR Avvisati G, 2003, CRIT REV ONCOL HEMAT, V48, pS13, DOI 10.1016/j.critrevonc.2003.04.001
   Cazzorla C, 2012, MOL GENET METAB, V106, P25, DOI 10.1016/j.ymgme.2012.02.008
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Cui X, 2016, BIOMED RES INT, V2016
   Cybularz PA, 2015, MED ACUPUNCT, V27, P224, DOI 10.1089/acu.2015.1099
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Karimlou M, 2011, ARCH IRAN MED, V14, P281, DOI 0011144/AIM.0011
   Ladas EJ, 2010, SUPPORT CARE CANCER, V18, P1487, DOI 10.1007/s00520-010-0926-6
   Li MK, 2015, NEURAL REGEN RES, V10, P1997, DOI 10.4103/1673-5374.172318
   Marrelli D, 2015, WORLD J GASTROENTERO, V21, P7954, DOI 10.3748/wjg.v21.i26.7954
   Min C, 2014, ONCOLOGY-BASEL, V86, P79, DOI 10.1159/000354641
   Paoletti X, 2010, JAMA-J AM MED ASSOC, V303, P1729, DOI 10.1001/jama.2010.534
   Rithirangsriroj K, 2015, GYNECOL ONCOL, V136, P82, DOI 10.1016/j.ygyno.2014.10.025
   Sakuramoto S, 2007, NEW ENGL J MED, V357, P1810, DOI 10.1056/NEJMoa072252
   Sasako M, 2011, J CLIN ONCOL, V29, P4387, DOI 10.1200/JCO.2011.36.5908
   Schiffer CA, 2001, J CLIN ONCOL, V19, P1519, DOI 10.1200/JCO.2001.19.5.1519
   Siegel R, 2013, CA-CANCER J CLIN, V2013, P6311
   Thompson LMA, 2015, J ACUPUNCT MERIDIAN, V8, P127, DOI 10.1016/j.jams.2015.04.002
   Waddell T, 2014, EJSO-EUR J SURG ONC, V40, P584, DOI 10.1016/j.ejso.2013.09.020
   Wan CH, 2011, INT J NURS STUD, V48, P1080, DOI 10.1016/j.ijnurstu.2011.02.012
   Wu XY, 2015, SCI REP-UK, V5, DOI 10.1038/srep16776
   Wu Y, 2016, J ZHEJIANG UNIV-SC B, V17, P169, DOI 10.1631/jzus.B1500301
   Yao C, 2016, CURR ONCOL, V23, pE27, DOI 10.3747/co.23.2788
   Yazdani K, 2015, IRAN J PUBLIC HEALTH, V44, P522
NR 24
TC 32
Z9 42
U1 1
U2 27
PU MULTIMED INC
PI TORONTO
PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA
SN 1198-0052
J9 CURR ONCOL
JI Curr. Oncol.
PD FEB
PY 2017
VL 24
IS 1
BP E1
EP E5
DI 10.3747/co.24.3296
PG 5
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA EM9TV
UT WOS:000395654900001
PM 28270726
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, GY
   Li, SQ
   Sun, LZ
   Lin, FC
   Wang, BG
AF Li, Guoyan
   Li, Shuqin
   Sun, Lizhi
   Lin, Fangcai
   Wang, Baoguo
TI RETRACTED: A comparison study of immune-inflammatory response in
   electroacupuncture and transcutaneous electrical nerve stimulation for
   patients undergoing supratentorial craniotomy(Retracted article. See
   vol.9,pg.20464,2016)
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article; Retracted Publication
DE Transcutaneous electrical nerve stimulation (TENS); electroacupuncture
   (EA); immuno-inflammatory; supratentorial craniotomy
ID LOW-BACK-PAIN; RATS; RELEASE; BLOCK
AB Objective: The effect of transcutaneous electrical nerve stimulation (TENS) on immuno-inflammatory response was tested and the differences between electroacupuncture (EA) and TENS in immuno-inflammatory response in patients undergoing supratentorial craniotomy were explored. Methods: 51 patients received craniotomy were divided randomly into 3 groups: control (group C, n=18), EA (group A, n=19) and TENS (group T, n=14) groups. Blood samples were collected before anesthesia (T0) and 30 min (T1), 2 h (T2) and 4 h (T3) after induction of anesthesia to measure the levels of tumor necrosis factor-a (TNF-alpha), interleukin (IL)-8, IL-10, IgM, IgA and IgG.. Results: No significant difference existed between groups A and group T during craniotomy. IgM and IgA decreased significantly in group C compared with groups A and T at T2 and T3 time points. Compared with group C, there were significant difference in TNF-alpha, IgM and IgA level at T0 in groups A and T; no significant difference was found in the levels of IgG, IL-10 and IL-8. Conclusion: EA and TENS could reduce immunosuppression in patients undergoing supratentorial craniotomy and it has significance in choice of treatment in immunosuppressive therapy.
C1 [Li, Guoyan; Sun, Lizhi] Beijing Elect Power Hosp, North China Grid Co Ltd, Dept Anesthesiol, Beijing, Peoples R China.
   [Li, Shuqin] Beijing Tiantan Hosp, Dept Anesthesiol, Beijing, Peoples R China.
   [Lin, Fangcai] Beijing Elect Power Hosp, North China Grid Co Ltd, Dept Gen Surg, Beijing, Peoples R China.
   [Wang, Baoguo] Beijing Sanbo Brain Hosp, Dept Anesthesiol & Pain Management, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Wang, BG (corresponding author), Sanbo Brain Hosp, Dept Anesthesiol, 50 Xiang Shan Yi Ke Song, Beijing 100093, Peoples R China.
EM baoguowang77@126.com
FU National Key Basic Research Program [2013-CB531901]; 
   [SGHBOOO-AJJS1400182]
FX This work was supported by the multidisciplinary study on chronic
   diseases in electric power system employees and the subprogram "the
   effect of different anesthetic methods on immune-inflammatory response
   in patients undergoing supratentorial craniotomy" (The state grid
   program of science and technology, SGHBOOO-AJJS1400182) and the National
   Key Basic Research Program on innovation and application study of
   combined acupuncture drug (2013-CB531901).
CR Arai YCP, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/727121
   Chen GY, 2010, NAT REV IMMUNOL, V10, P826, DOI 10.1038/nri2873
   Chu H, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-84
   DeSantana Josimari M, 2008, Curr Rheumatol Rep, V10, P492
   Ding LC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057477
   Fang JF, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-134
   Gu G, 2011, J INT MED RES, V39, P1783, DOI 10.1177/147323001103900521
   Keskin EA, 2012, GYNECOL OBSTET INVES, V74, P76, DOI 10.1159/000337720
   Khalil Z, 2000, J GERONTOL A-BIOL, V55, pB257, DOI 10.1093/gerona/55.6.B257
   Kita K, 2013, J NEUROENG REHABIL, V10, DOI 10.1186/1743-0003-10-55
   Kloth L C, 1996, Adv Wound Care, V9, P42
   Koca Kutlu A, 2013, EVID-BASED COMPL ALT, V2013
   Lan F, 2012, MINERVA ANESTESIOL, V78, P887
   Li GY, 2013, ACUPUNCT MED, V31, P51, DOI 10.1136/acupmed-2012-010254
   Liu SJ, 2011, ANESTH ANALG, V113, P572, DOI 10.1213/ANE.0b013e3182278237
   Pinosky ML, 1996, ANESTH ANALG, V83, P1256, DOI 10.1097/00000539-199612000-00022
   Sabino GS, 2008, J PAIN, V9, P157, DOI 10.1016/j.jpain.2007.09.003
   Sluka KA, 2006, ARCH PHYS MED REHAB, V87, P1137, DOI 10.1016/j.apmr.2006.04.023
   Stein C, 2013, BRAZ J PHYS THER, V17, P93, DOI 10.1590/S1413-35552012005000083
   Trinh K, 2007, SPINE, V32, P236, DOI 10.1097/01.brs.0000252100.61002.d4
   WANG JQ, 1992, INT J NEUROSCI, V65, P117, DOI 10.3109/00207459209003283
   Yokoyama M, 2001, ANESTH ANALG, V92, P463, DOI 10.1213/00000539-200102000-00035
   Zaniewska R, 2012, MED PR, V63, P295
   Zhang WT, 2003, NEUROREPORT, V14, P1591, DOI 10.1097/00001756-200308260-00010
NR 24
TC 4
Z9 6
U1 0
U2 11
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2015
VL 8
IS 2
BP 2662
EP 2667
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CJ2HX
UT WOS:000355306000132
PM 25932216
DA 2026-01-16
ER

PT J
AU Sheng, GY
   Yang, J
   Rong, P
   Yang, XY
AF Sheng, Guanyun
   Yang, Jing
   Rong, Peng
   Yang, Xueyi
TI RETRACTED: Effects of Warm Needle Acupuncture plus Xitong Waixi Lotion
   in Patients with Knee Osteoarthritis: A Randomized Controlled Trial
   (Retracted Article)
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article; Retracted Publication
AB Objective. To evaluate the effect of warm needle acupuncture plus Xitong Waixi lotion on the levels of IL-1, TNF-alpha, and MMP-3 in patients with knee osteoarthritis. Methods. Eighty patients with knee osteoarthritis admitted to our hospital from October 2019 to June 2021 were recruited and assigned via the random number table method at a ratio of 1:1 to receive either Xitong Waixi lotion (conventional group) or warm needle acupuncture plus Xitong Waixi lotion (combined group). Outcome measures included clinical efficacy, inflammatory cytokine level, Western Ontario and McMaster Universities Arthritis Index (WOMAC) score, visual analogue scale (VAS) score, Hospital for Special Surgery (HSS) knee score, and adverse reactions. Results. Warm needle acupuncture plus Xitong Waixi lotion was associated with a significantly higher clinical efficacy versus Xitong Waixi lotion alone (P = 0.006). Patients in the combined group had significantly lower levels of interleukin (IL)-1, tumor necrosis factor-alpha (TNF-alpha), and matrix metalloproteinase-3 (MMP-3) than those in the conventional group (P = 0.020). Warm needle acupuncture plus Xitong Waixi lotion resulted in significantly lower WOMAC scores and VAS scores and higher HSS scores for the patients versus Xitong Waixi lotion (P = 0.012). The two groups had a similar incidence of adverse events (P = 0.068). Conclusion. Warm needle acupuncture plus Xitong Waixi lotion effectively alleviates the inflammatory response and knee pain in patients with knee osteoarthritis, with significant clinical effects and a high safety profile.
C1 [Sheng, Guanyun; Yang, Xueyi] Guangxi Univ Chinese Med, Liuzhou Tradit Chinese Med Hosp, Dept Orthopaed, Liuzhou 545001, Peoples R China.
   [Yang, Jing] Guangxi Univ Chinese Med, Liuzhou Tradit Chinese Med Hosp, Intens Care Unit, Liuzhou 545001, Peoples R China.
   [Rong, Peng] Guangxi Univ Chinese Med, Grad Sch, Nanning 530000, Peoples R China.
C3 Guangxi University of Chinese Medicine; Guangxi University of Chinese
   Medicine; Guangxi University of Chinese Medicine
RP Yang, XY (corresponding author), Guangxi Univ Chinese Med, Liuzhou Tradit Chinese Med Hosp, Dept Orthopaed, Liuzhou 545001, Peoples R China.
EM leiyixie6132476816@163.com
FU Guangxi Natural Science Foundation Program;  [2018GXNSFAA050103]
FX AcknowledgmentsThis work was supported by the Guangxi Natural Science
   Foundation Program (2018GXNSFAA050103).
CR Adly AS, 2021, J TELEMED TELECARE, V27, P298, DOI 10.1177/1357633X211009861
   Aljasir B, 2010, EVID-BASED COMPL ALT, V7, P399, DOI 10.1093/ecam/nen027
   Barnard A, 2020, J HAND SURG-EUR VOL, V45, P488, DOI 10.1177/1753193420911326
   Chen RX, 2010, BMC COMPLEM ALTERN M, V10, DOI 10.1186/1472-6882-10-32
   Chen WJ, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.752556
   Chen WJ, 2021, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.601606
   Chi XS, 2020, CHIN MED-UK, V15, DOI 10.1186/s13020-020-0297-y
   da Costa BR, 2021, BMJ-BRIT MED J, V375, DOI 10.1136/bmj.n2321
   Davidson Patricia, 2003, Eur J Cardiovasc Nurs, V2, P171, DOI 10.1016/S1474-5151(03)00057-4
   Guo Yao-Guang, 2021, Zhen Ci Yan Jiu, V46, P145, DOI [10.13702/j.1000-0607.200181, 10.13702/j.1000-0607.200181]
   Hashemi MS, 2019, EUR J INTEGR MED, V29, DOI 10.1016/j.eujim.2019.100929
   Jorge Liliana L, 2010, J Pain Res, V4, P11, DOI 10.2147/JPR.S9492
   Kolasinski SL, 2020, ARTHRITIS RHEUMATOL, V72, P220, DOI [10.1002/art.41142, 10.1002/acr.24131]
   Lee G, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000023527
   Li J, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016301
   Liang H, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/8161731
   Liu Jing, 2020, Zhen Ci Yan Jiu, V45, P914, DOI [10.13702/j.1000-0607.190848, 10.13702/j.1000-0607.190848]
   Luo HF, 2021, TRIALS, V22, DOI 10.1186/s13063-021-05514-z
   Luo HF, 2021, TRIALS, V22, DOI 10.1186/s13063-021-05416-0
   Lv Shan-Guang, 2021, Zhongguo Zhen Jiu, V41, P999, DOI [10.13703/j.0255-2930.20200721-k0008, 10.13703/j.0255-2930.20200721-k0008]
   Ma YF, 2019, Journal of Integrative Nursing, V1, P73, DOI [10.35437/intnur.issn.2663-4481.2019.01.02.02, 10.35437/intnur.issn.2663-4481.2019.01.02.02, DOI 10.35437/INTNUR.ISSN.2663-4481.2019.01.02.02]
   Marchetti G, 2020, ACUPUNCT MED, V38, P440, DOI 10.1177/0964528420920281
   Morgan MM, 2011, BRIT J PHARMACOL, V164, P1322, DOI 10.1111/j.1476-5381.2011.01335.x
   Nayebi Neda, 2019, J Complement Integr Med, V16, DOI [10.1515/jcim-2018-0088, 10.1515/jcim-2018-0088]
   Qu Xiao-Dong, 2019, Zhongguo Gu Shang, V32, P493, DOI 10.3969/j.issn.1003-0034.2019.06.002
   Ren SJ, 2021, J NANOBIOTECHNOL, V19, DOI 10.1186/s12951-021-01157-z
   Riddle DL, 2020, OSTEOARTHR CARTILAGE, V28, pS360
   Shang JW, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000026859
   Shang JW, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021857
   Shen D, 2021, PURINERG SIGNAL, V17, P411, DOI 10.1007/s11302-021-09777-8
   Smolen JS, 2019, LANCET, V393, P2303, DOI 10.1016/S0140-6736(19)30419-2
   Suarez-Almazor ME, 2010, JCR-J CLIN RHEUMATOL, V16, P158, DOI 10.1097/RHU.0b013e3181df4de4
   Tong J, 2022, PAIN RES MANAG, V2022, DOI 10.1155/2022/9939891
   Tu JF, 2021, ARTHRITIS RHEUMATOL, V73, P448, DOI 10.1002/art.41584
   Uckay Ilker, 2019, Foot Ankle Int, V40, p3S, DOI [10.1177/1071100719857082, 10.1177/1071100719857082]
   Zheng YW, 2021, LIFE-BASEL, V11, DOI 10.3390/life11060513
NR 36
TC 0
Z9 1
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD AUG 5
PY 2022
VL 2022
AR 5467712
DI 10.1155/2022/5467712
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 3Z7XB
UT WOS:000844628800008
PM 35966733
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Anand, K
   Niravath, P
AF Anand, Kartik
   Niravath, Polly
TI Acupuncture and Vitamin D for the Management of Aromatase
   Inhibitor-Induced Arthralgia
SO CURRENT ONCOLOGY REPORTS
LA English
DT Review
DE Acupuncture; Vitamin D; Aromatase inhibitor; Breast cancer; Arthralgia;
   Quality of life; Breast cancer survivors
ID STAGE BREAST-CANCER; MUSCULOSKELETAL SYMPTOMS; POSTMENOPAUSAL WOMEN;
   JOINT SYMPTOMS; INFLAMMATORY CYTOKINES; RANDOMIZED-TRIAL; PLACEBO; PAIN;
   MULTICENTER; PREVALENCE
AB Purpose of ReviewAromatase inhibitor-induced arthralgia (AIA) is a very common syndrome which significantly affects breast cancer survivors' quality of life, and it often leads to non-compliance with aromatase inhibitor (AI) therapy. However, the treatment of AIA remains a clinical challenge. Here, we will review the current data for acupuncture and vitamin D in the management of AIA.Recent FindingsAcupuncture has been shown to improve AIA symptoms, but it has not consistently been proven to offer significantly more clinical benefit than sham acupuncture. Similarly, while some vitamin D trials have shown benefit, the studies have not consistently shown improvement in AIA symptoms.SummaryNeither acupuncture nor vitamin D can be touted as standard treatments for AIA. However, many patients do experience subjective improvement of their symptoms with these therapies. When other treatments, such as exercise and duloxetine, are not feasible or not effective, it is reasonable to offer a trial of acupuncture or vitamin D to patients who are suffering from AIA, as the potential harms are very few, and they do offer possible relief from AIA symptoms.
C1 [Anand, Kartik; Niravath, Polly] Weill Cornell Med, Houston Methodist Canc Ctr, Outpatient Tower,Floor 24,6445 Main St, Houston, TX 77030 USA.
C3 Houston Methodist
RP Niravath, P (corresponding author), Weill Cornell Med, Houston Methodist Canc Ctr, Outpatient Tower,Floor 24,6445 Main St, Houston, TX 77030 USA.
EM paniravath@houstonmethodist.org
RI Anand, Kartik/K-1370-2019
OI Anand, Kartik/0000-0003-4480-1443
CR Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Boonstra A, 2013, CANCER NURS, V36, P52, DOI 10.1097/NCC.0b013e31824a7e18
   Briot K, 2010, BREAST CANCER RES TR, V120, P127, DOI 10.1007/s10549-009-0692-7
   Chlebowski RT, 2011, MATURITAS, V68, P73, DOI 10.1016/j.maturitas.2010.10.006
   Coleman RE, 2012, CANCER RES, V72, DOI 10.1158/0008-5472.SABCS12-S6-4
   Crew KD, 2007, J CLIN ONCOL, V25, P3877, DOI 10.1200/JCO.2007.10.7573
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Dowsett M, 2015, LANCET, V386, P1341, DOI 10.1016/S0140-6736(15)61074-1
   Ezzo J, 2001, ARTHRITIS RHEUM, V44, DOI [10.1002/1529-0131(200104)44:4, DOI 10.1002/1529-0131(200104)44:4<LESSTHAN>819::AID-ANR138<GREATERTHAN>3.0.CO;2-P]
   Fenlon D, 2013, J PAIN SYMPTOM MANAG, V46, P523, DOI 10.1016/j.jpainsymman.2012.10.282
   GALLAGHER JC, 1980, J CLIN ENDOCR METAB, V51, P1359, DOI 10.1210/jcem-51-6-1359
   Goss PE, 2003, NEW ENGL J MED, V349, P1793, DOI 10.1056/NEJMoa032312
   Grossmann RE, 2012, EUR J CLIN NUTR, V66, P1072, DOI 10.1038/ejcn.2012.82
   Henry NL, 2018, J CLIN ONCOL, V36, P326, DOI 10.1200/JCO.2017.74.6651
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hershman DL, 2015, J CLIN ONCOL, V33, P1910, DOI 10.1200/JCO.2014.59.5595
   Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
   Imtiaz Saba, 2012, Indian J Endocrinol Metab, V16, P409, DOI 10.4103/2230-8210.95684
   Irwin ML, 2015, J CLIN ONCOL, V33, P1104, DOI 10.1200/JCO.2014.57.1547
   Khan QJ, 2017, BREAST CANCER RES TR, V166, P491, DOI 10.1007/s10549-017-4429-8
   Khan QJ, 2010, BREAST CANCER RES TR, V119, P111, DOI 10.1007/s10549-009-0495-x
   Lim HD, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151882
   Linde K, 2007, PAIN, V128, P264, DOI 10.1016/j.pain.2006.12.006
   Lonning PE, 2005, J CLIN ONCOL, V23, P5126, DOI 10.1200/JCO.2005.07.097
   MacPherson H, 2016, J ALTERN COMPLEM MED, V22, P101, DOI 10.1089/acm.2015.0184
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Miller WR, 2003, SEMIN ONCOL, V30, P3, DOI 10.1016/S0093-7754(03)00302-6
   Murphy CC, 2012, BREAST CANCER RES TR, V134, P459, DOI 10.1007/s10549-012-2114-5
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Niravath P, 2018, SAN ANT BREAST CANC
   Niravath P, 2018, CLIN BREAST CANCER, V18, P78, DOI 10.1016/j.clbc.2017.10.009
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Park JY, 2013, J KOREAN SURG SOC, V85, P205, DOI 10.4174/jkss.2013.85.5.205
   Plotnikoff GA, 2003, MAYO CLIN PROC, V78, P1463, DOI 10.4065/78.12.1463
   Prieto-Alhambra D, 2012, BREAST CANCER RES TR, V133, P1159, DOI 10.1007/s10549-012-2013-9
   Rastelli AL, 2011, BREAST CANCER RES TR, V129, P107, DOI 10.1007/s10549-011-1644-6
   Sandberg M, 2003, EUR J APPL PHYSIOL, V90, P114, DOI 10.1007/s00421-003-0825-3
   Sestak I, 2008, LANCET ONCOL, V9, P866, DOI 10.1016/S1470-2045(08)70182-7
   Shapiro AC, 2016, BREAST CANCER RES TR, V155, P501, DOI 10.1007/s10549-016-3710-6
   Sierpina VS, 2005, SOUTH MED J, V98, P330, DOI 10.1097/01.SMJ.0000140834.30654.0F
   Sims J., 1997, Complementary Therapies in Medicine, V5, P102, DOI [DOI 10.1016/S0965-2299, DOI 10.1016/S0965-2299(97)80008-8]
   Singh S, 2012, BREAST CANCER RES TR, V132, P625, DOI 10.1007/s10549-011-1911-6
   Villaggio B, 2012, CLIN EXP RHEUMATOL, V30, P934
   Wu XK, 2017, JAMA-J AM MED ASSOC, V317, P2502, DOI 10.1001/jama.2017.7217
   Zhang Y, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/710750
NR 46
TC 10
Z9 11
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3790
EI 1534-6269
J9 CURR ONCOL REP
JI Curr. Oncol. Rep.
PD JUN
PY 2019
VL 21
IS 6
AR 51
DI 10.1007/s11912-019-0795-1
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA HU0ZO
UT WOS:000465001400001
PM 30997616
DA 2026-01-16
ER

PT J
AU Mazzei, LG
   Bergamaschi, CD
   Silva, MT
   Lopes, LC
AF Mazzei, Lauren Giustti
   Bergamaschi, Cristiane de Cassia
   Silva, Marcus Tolentino
   Lopes, Luciane Cruz
TI Use of IMMPACT domains in clinical trials of acupuncture for chronic
   pain: a protocol for a methodological survey
SO BMJ OPEN
LA English
DT Article
ID COST
AB Introduction Pain is one of the most common and most debilitating complaints among patients. It affects the individual, their relationship with friends and family, their ability to function at work, and their sociability. Acupuncture is one of the therapeutic resources for managing chronic pain. Given the variability of outcome measures in controlled randomised clinical trials on non-oncologicchronic pain (CRCT-NOCP), the Initiative in Methods, Measurements and Pain Assessment in Clinical Trials (IMMPACT) recommends six domains to be covered in evaluating the effectiveness of treatments for chronic pain.
   Objective To check whether the methodological quality of outcome reporting in published trials has used IMMPACT recommendations in measuring CRCT-NOCP outcomes when acupuncture was used as a treatment.
   Method This is a methodological study. We will systematically search for eligible studies in specific databases with a defined strategy. We will use the MeSHterms of 'acupuncture', 'chronic pain' and similar terms, without restrictions on idiom. Eligible studies will include those which are randomised and chose NOCP patients to be treated with acupuncture or control (sham acupuncture or no acupuncture), recruited after September 2004, with >= 100 patients. The measured outcomes are to be the presence of outcome domains recommended by IMMPACT, domains reported by the patient or clinician, tools used to measure such domains, as well as other features of the studies. We shall conduct a regression analysis to explore factors which can be associated with the presence of outcome domains according to IMMPACT recommendations.
   Ethics and dissemination This survey will be submitted for presentation at congresses and for publication in a scientific journal. The findings obtained in this study will allow us to measure the quality of the evidence and provide greater transparency in decisions regarding the use of acupuncture as a viable alternative to managing chronic pain.
C1 [Mazzei, Lauren Giustti; Bergamaschi, Cristiane de Cassia; Silva, Marcus Tolentino; Lopes, Luciane Cruz] Univ Sorocaba, Dept Pharmaceut Sci, Grad Program, Sao Paulo, Brazil.
C3 Universidade de Sorocaba
RP Lopes, LC (corresponding author), Univ Sorocaba, Dept Pharmaceut Sci, Grad Program, Sao Paulo, Brazil.
EM luslopes@terra.com.br
RI Silva, Marcus Tolentino/J-1791-2014; Bergamaschi, Cristiane de
   Cássia/F-9911-2014; Lopes, Luciane/H-3159-2019
OI Silva, Marcus Tolentino/0000-0002-7186-9075; Bergamaschi, Cristiane de
   Cássia/0000-0002-6608-1806; Lopes, Luciane/0000-0002-3684-3275
CR Akl EA, 2012, J CLIN EPIDEMIOL, V65, P262, DOI 10.1016/j.jclinepi.2011.04.015
   [Anonymous], 2013, Management of chronic pain: a national clinical guideline
   [Anonymous], POL NAC PRAT INT COM
   [Anonymous], MODIFICATION COCHRAN
   [Anonymous], 2013, [No title captured]
   Azevedo LF, 2016, EUR J HEALTH ECON, V17, P87, DOI 10.1007/s10198-014-0659-4
   Santos CMD, 2007, REV LAT-AM ENFERM, V15, P508, DOI 10.1590/S0104-11692007000300023
   Dworkin RH, 2005, PAIN, V113, P9, DOI 10.1016/j.pain.2004.09.012
   Dworkin RH, 2010, PAIN, V149, P177, DOI 10.1016/j.pain.2010.02.018
   Guerriere DN, 2010, CAN J ANAESTH, V57, P549, DOI 10.1007/s12630-010-9306-4
   Higgins J., 2011, COCHRANE COLLABORATI
   National Guideline, 2011, PAIN
   OMdl Salud, 2013, ESTR OMS MED TRAD 20
   Ontario CPSO, 2000, EV BAS REC MED MAN C
   Rasu RS, 2014, J MANAG CARE SPEC PH, V20, P921, DOI 10.18553/jmcp.2014.20.9.921
   Rosenquist RW, 2010, ANESTHESIOLOGY, V112, P810, DOI 10.1097/ALN.0b013e3181c43103
   Turk DC, 2003, PAIN, V106, P337, DOI 10.1016/j.pain.2003.08.001
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
NR 18
TC 1
Z9 1
U1 0
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD SEP
PY 2017
VL 7
IS 9
AR e014904
DI 10.1136/bmjopen-2016-014904
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FJ3RY
UT WOS:000412650700030
PM 28963280
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Domnick, M
   Domnick, M
   Wiebelitz, KR
   Beer, AM
AF Domnick, Martin
   Domnick, Manju
   Wiebelitz, Karl-Ruediger
   Beer, Andre-Michael
TI Evaluation of the Effectiveness of a Multimodal Complementary Medicine
   Program for Improving the Quality of Life of Cancer Patients during
   Adjuvant Radiotherapy and/or Chemotherapy or Outpatient Aftercare
SO ONCOLOGY
LA English
DT Article
DE Complementary therapy; Integrative oncology; Quality of life; Entity
   spanning; Multimodal
ID BREAST-CANCER; INTEGRATIVE ONCOLOGY; MISTLETOE EXTRACT; INDUCED NAUSEA;
   ACUPUNCTURE; FATIGUE; PAIN; THERAPIES; ACUPRESSURE; MEDITATION
AB Objectives: Evidence for complementary therapies as important strategies to relieve cancer treatment-associated symptoms is increasing. Mostly, these complementary therapies start at the end of adjuvant treatments, resulting in a long delay until the well-being of patients is addressed. Further, long distances between the rehabilitation center and the patients' residence hinder patients' compliance. Methods: The multimodal outpatient LOTUS Care Cure Project (LCCP) was tested in a randomized controlled trial including patients of various cancer entities and stages while on adjuvant chemotherapy and/or radiotherapy or outpatient aftercare. The intervention group received the LCCP additionally to the conventional treatment (LCCP group, n = 50). The control group (CG) was split into 2 groups, with (CG1, n = 33) and without (CG2, n = 17) weekly talks. The primary endpoint was quality of life (QoL) after 3 months. Results: In the LCCP group, QoL significantly improved after 3 months compared to CG2 (p = 0.022) but not compared to CG1. Other parameters showing a significant improvement were cognitive (p < 0.05, vs. CG1 and CG2) and social function (p < 0.05, vs. CG2). Conclusions: This pilot study describes a multimodal outpatient complementary therapy program conducted in parallel with conventional therapies and its potential to significantly improve QoL and reduce treatment-associated side effects. To substantiate these data, multicenter trials are needed. (C) 2017 S. Karger AG, Basel
C1 [Domnick, Martin; Domnick, Manju] Praxisklin & Internist Gemeinschaftspraxis Domnic, Josefstr 14-16, DE-45699 Herten, Germany.
   [Wiebelitz, Karl-Ruediger] Kreiskrankenhaus Prignitz Gemeinnutzige GmbH, Klin Kinder & Jugendmed, Prignitz, Germany.
   [Beer, Andre-Michael] Katholisches Klinikum Bochum, Klin Naturheilkunde Klin Blankenstein, Bochum, Germany.
C3 Ruhr University Bochum
RP Domnick, M (corresponding author), Praxisklin & Internist Gemeinschaftspraxis Domnic, Josefstr 14-16, DE-45699 Herten, Germany.
EM m.m.domnick@praxis-klinik-domnick.de
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Bar-Sela G, 2013, EUR J CANCER, V49, P1058, DOI 10.1016/j.ejca.2012.11.007
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Ben-Arye E, 2015, CLIN NUTR, V34, P1215, DOI 10.1016/j.clnu.2014.12.011
   Ben-Arye E, 2015, SUPPORT CARE CANCER, V23, P3411, DOI 10.1007/s00520-015-2690-0
   Carlson Linda E., 2014, Journal of the National Cancer Institute Monographs, P308, DOI 10.1093/jncimonographs/lgu034
   Cassileth B, 2006, ONCOLOGY-NY, V20, P1302
   Cassileth BR, 2007, CHEST, V132, p340S, DOI 10.1378/chest.07-1389
   Collins Kimberly B, 2004, J Am Acad Nurse Pract, V16, P76
   Deng G, 2005, CA-CANCER J CLIN, V55, P109, DOI 10.3322/canjclin.55.2.109
   Dobos GJ, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-539
   Fayer P, 2001, EORTC QLQ C30 SCORIN, Vthird
   Frass M, 2015, COMPLEMENT THER MED, V23, P309, DOI 10.1016/j.ctim.2015.03.004
   Geissner E, 1995, Rehabilitation (Stuttg), V34, pXXXV
   Hautzinger M., 1994, Beck-Depressions-Inventar (BDI)
   Horneber M, 2012, DTSCH ARZTEBL INT, V109, P161, DOI 10.3238/arztebl.2012.0161
   International Agency for Research on Cancer, 2014, WORLD CANC REPORT 20
   KABATZINN J, 1982, GEN HOSP PSYCHIAT, V4, P33, DOI 10.1016/0163-8343(82)90026-3
   KABATZINN J, 1992, AM J PSYCHIAT, V149, P936
   Klafke N, 2016, SUPPORT CARE CANCER, V24, P2341, DOI 10.1007/s00520-015-3038-5
   Lenartz D, 1996, ANTICANCER RES, V16, P3799
   McKeon C, 2015, ACUPUNCT MED, V33, P277, DOI 10.1136/acupmed-2015-010781
   Melchart D, 2006, SUPPORT CARE CANCER, V14, P878, DOI 10.1007/s00520-006-0028-7
   Mohammadzadeh M, 2013, INTEGR CANCER THER, V12, P496, DOI 10.1177/1534735413485417
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P228, DOI 10.1016/j.ctim.2006.09.009
   Piao BK, 2004, ANTICANCER RES, V24, P303
   Running A, 2012, CURR PAIN HEADACHE R, V16, P325, DOI 10.1007/s11916-012-0275-x
   Schumacher K, 2003, ANTICANCER RES, V23, P5081
   Senf B, 2010, SUPPORT CARE CANCER, V18, P957, DOI 10.1007/s00520-010-0850-9
   Sharabi IS, 2016, SUPPORT CARE CANCER, V24, P4345, DOI 10.1007/s00520-016-3274-3
   Smith C, 2013, ACUPUNCT MED, V31, P9, DOI 10.1136/acupmed-2012-010228
   Spahn G, 2013, INTEGR CANCER THER, V12, P291, DOI 10.1177/1534735413492727
   Sudarshan M, 2013, COMPLEMENT THER CLIN, V19, P227, DOI 10.1016/j.ctcp.2013.06.004
   Weze Clare, 2004, Eur J Oncol Nurs, V8, P40, DOI 10.1016/j.ejon.2003.10.004
   Witt CM, 2015, BREAST CANCER RES TR, V149, P449, DOI 10.1007/s10549-014-3249-3
NR 35
TC 8
Z9 11
U1 1
U2 17
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0030-2414
EI 1423-0232
J9 ONCOLOGY-BASEL
JI Oncology
PY 2017
VL 93
IS 2
BP 83
EP 91
DI 10.1159/000468939
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA FC1KM
UT WOS:000406596000002
PM 28472802
DA 2026-01-16
ER

PT J
AU Enblom, A
   Johnsson, A
   Hammar, M
   Onelöv, E
   Steineck, G
   Börjeson, S
AF Enblom, A.
   Johnsson, A.
   Hammar, M.
   Onelov, E.
   Steineck, G.
   Borjeson, S.
TI Acupuncture compared with placebo acupuncture in radiotherapy-induced
   nausea-a randomized controlled study
SO ANNALS OF ONCOLOGY
LA English
DT Article
DE acupuncture therapy; cancer; complementary medicine; emesis;
   radiotherapy
ID SINGLE-BLIND; STIMULATION; NEEDLE; CHEMOTHERAPY; EXPECTANCY; EMESIS
AB It is not known if verum (real) acupuncture is effective for nausea and vomiting (emesis) during radiotherapy.
   We randomly treated 215 blinded cancer patients with verum: penetrating 'deqi' creating acupuncture (n = 109) or non-penetrating sham needles (n = 106) two to three times per week. The patients documented emesis daily during the radiotherapy period. Primary end point was the number of patients with at least one episode of nausea.
   In the verum and the sham acupuncture group, 70% and 62% experienced nausea at least once during the radiotherapy period (relative risk 1.1, 95% CI 0.9-1.4) for a mean number of 10.1 and 8.7 days. Twenty five percent and 28% vomited, and 42% and 37% used antiemetic drugs at least once, respectively. Ninety-five percent in the verum acupuncture group and 96% in the sham acupuncture group believed that the treatment had been effective against nausea. In both groups, 67% experienced positive effects on relaxation, mood, sleep or pain reduction and 89% wished to receive the treatment again.
   Acupuncture creating deqi is not more effective than sham in radiotherapy-induced nausea, but in this study, nearly all patients in both groups experienced that the treatment was effective for nausea.
C1 [Enblom, A.] Karolinska Inst, Osher Ctr Integrat Med, Dept Clin Neurosci, SE-17177 Stockholm, Sweden.
   [Enblom, A.; Borjeson, S.] Linkoping Univ, Dept Med & Hlth Sci, Div Nursing Sci, Linkoping, Sweden.
   [Enblom, A.] Lund Univ, Swedish Inst Hlth Sci, Lund, Sweden.
   [Johnsson, A.] Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden.
   [Hammar, M.] Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.
   [Onelov, E.; Steineck, G.] Karolinska Inst, Dept Oncol Pathol, Div Clin Canc Epidemiol, SE-17177 Stockholm, Sweden.
   [Borjeson, S.] Linkoping Univ Hosp, Dept Oncol, Ctr Surg & Oncol, S-58185 Linkoping, Sweden.
   [Steineck, G.] Sahlgrens Acad, Dept Oncol, Div Clin Canc Epidemiol, Gothenburg, Sweden.
C3 Karolinska Institutet; Linkoping University; Lund University; Lund
   University; Skane University Hospital; Linkoping University; Karolinska
   Institutet; Linkoping University; University of Gothenburg
RP Enblom, A (corresponding author), Karolinska Inst, Osher Ctr Integrat Med, Dept Clin Neurosci, SE-17177 Stockholm, Sweden.
EM anna.enblom@ki.se
RI Hammar, Mats/R-7908-2019; Steineck, Gunnar/W-1515-2019
OI Johnsson, Anna/0000-0001-9347-5336; Börjeson,
   Sussanne/0000-0002-9786-7326; Steineck, Gunnar/0000-0002-0787-3969
FU Swedish Cancer Society [04 0483]; Swedish Institute for Health Sciences
   (the Vardal institute); County Council of Ostergotland [LIO-4998,
   2005-279-83, LIO-4762, LIO-7433, LIO-10456, LIO-20071]; University of
   Linkoping [C 40111]; Vardal Foundation-for Health Care Sciences and
   Allergy Research; Ostgota Cancer Fund
FX Swedish Cancer Society (04 0483); the Swedish Institute for Health
   Sciences (the Vardal institute); County Council of Ostergotland
   (LIO-4998, 2005-279-83, LIO-4762, LIO-7433, LIO-10456, LIO-20071);
   University of Linkoping, Cancer and Traffic Injury Fund (C 40111);
   Vardal Foundation-for Health Care Sciences and Allergy Research and the
   Ostgota Cancer Fund.
CR Abdelsayed GG, 2007, EXP HEMATOL, V35, P34, DOI 10.1016/j.exphem.2007.01.010
   Anna E, 2008, COMPLEMENT THER MED, V16, P288, DOI 10.1016/j.ctim.2008.02.012
   Bausell RB, 2005, EVAL HEALTH PROF, V28, P9, DOI 10.1177/0163278704273081
   Borjeson S, 1997, CANCER NURS, V20, P260
   Cao XD, 2002, ACUPUNCTURE ELECTRO, V27, P1
   Carlsson Christer, 2002, Acupunct Med, V20, P82
   Enblom A, 2011, ACUPUNCT MED, V29, P94, DOI 10.1136/aim.2010.003384
   Enblom A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014766
   Enblom A, 2009, SUPPORT CARE CANCER, V17, P23, DOI 10.1007/s00520-008-0445-x
   Ezzo JM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002285.pub2
   Feyer PC, 2011, SUPPORT CARE CANCER, V19, pS5, DOI 10.1007/s00520-010-0950-6
   Hendley GW, 2005, ANN EMERG MED, V45, P77, DOI 10.1016/j.annemergmed.2004.07.446
   Hui KKS, 2005, NEUROIMAGE, V27, P479, DOI 10.1016/j.neuroimage.2005.04.037
   Johnstone PAS, 2002, PALLIATIVE MED, V16, P235, DOI 10.1191/0269216302pm540oa
   Lai XS, 2009, NEUROSCI LETT, V452, P194, DOI 10.1016/j.neulet.2009.01.052
   Lee A, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003281.pub3
   Liu S, 2007, NEUROSCI LETT, V421, P203, DOI 10.1016/j.neulet.2007.04.078
   MacPherson Hugh, 2010, J Evid Based Med, V3, P140, DOI 10.1111/j.1756-5391.2010.01086.x
   Maranzano E, 1999, INT J RADIAT ONCOL, V44, P619, DOI 10.1016/S0360-3016(99)00055-3
   Matthews A, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007575.pub2
   Miller FG, 2004, JAMA-J AM MED ASSOC, V291, P599, DOI 10.1001/jama.291.5.599
   Mystakidou K, 2006, MED ONCOL, V23, P251, DOI 10.1385/MO:23:2:251
   Pariente J, 2005, NEUROIMAGE, V25, P1161, DOI 10.1016/j.neuroimage.2005.01.016
   Park H, 2002, AM J CHINESE MED, V30, P45, DOI 10.1142/S0192415X02000053
   Park J, 2005, ARCH INTERN MED, V165, P2026, DOI 10.1001/archinte.165.17.2026
   Park J., 1999, ACUPUNCT MED, V17, P110
   Park Jongbae, 2002, Acupunct Med, V20, P168
   Richardson MA, 2000, J CLIN ONCOL, V18, P2505, DOI 10.1200/JCO.2000.18.13.2505
   Roscoe JA, 2009, J PAIN SYMPTOM MANAG, V38, P381, DOI 10.1016/j.jpainsymman.2008.09.006
   Sandberg M, 2004, EUR J PAIN, V8, P163, DOI 10.1016/S1090-3801(03)00090-9
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   Steineck G, 2006, ACTA ONCOL, V45, P421, DOI 10.1080/02841860600649293
   Streitberger K, 1998, LANCET, V352, P364, DOI 10.1016/S0140-6736(97)10471-8
   Streitberger K, 2003, CLIN CANCER RES, V9, P2538
   Streitberger K, 2006, AUTON NEUROSCI-BASIC, V129, P107, DOI 10.1016/j.autneu.2006.07.015
   White A, 2001, BRIT MED J, V323, P485, DOI 10.1136/bmj.323.7311.485
   White P, 2003, PAIN, V106, P401, DOI 10.1016/j.pain.2003.08.013
   Yoo SS, 2004, NEUROIMAGE, V22, P932, DOI 10.1016/j.neuroimage.2004.02.017
NR 38
TC 72
Z9 83
U1 2
U2 27
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0923-7534
EI 1569-8041
J9 ANN ONCOL
JI Ann. Oncol.
PD MAY
PY 2012
VL 23
IS 5
BP 1353
EP 1361
DI 10.1093/annonc/mdr402
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 933CH
UT WOS:000303336400040
OA Bronze
DA 2026-01-16
ER

PT J
AU Wang, J
   Lu, FF
   Ge, MM
   Wang, LW
   Wang, G
   Gong, GW
   Liu, XX
   Zhang, WZ
   Ning, FL
   Chen, BH
   Liu, Y
   Quan, HG
   Jiang, ZW
AF Wang, Jun
   Lu, Fei-Fei
   Ge, Miao-Miao
   Wang, Li-Wen
   Wang, Gang
   Gong, Guan-Wen
   Liu, Xin-Xin
   Zhang, Wen-Zhuo
   Ning, Fei-Long
   Chen, Bao-He
   Liu, Yang
   Quan, Hong-Guang
   Jiang, Zhi-Wei
TI Transcutaneous Electrical Acupoint Stimulation Improves Postoperative
   Sleep Quality in Patients Undergoing Laparoscopic Gastrointestinal Tumor
   Surgery: A Prospective, Randomized Controlled Trial
SO PAIN AND THERAPY
LA English
DT Article
DE Transcutaneous electrical acupoint stimulation; Sleep quality;
   Gastrointestinal tumor; NRF2; Inflammation
ID OXIDATIVE STRESS; ELECTROACUPUNCTURE; PAIN; DEPRIVATION; DYSFUNCTION;
   ACTIVATION
AB Introduction: This study was conducted to observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on the postoperative sleep quality of patients undergoing gastrointestinal tumor surgery and to verify the possible mechanism.Methods: Eighty-three patients were allocated to the TEAS or Sham group. Patients in the TEAS group received TEAS treatment (disperse-dense waves; frequency, 2/100 Hz) on bilateral Shenmen (HT7), Neiguan (PC6) and Zusanli (ST36) points for 30 min each time, total three times in the perioperative period. In the Sham group, electrodes were placed; however, no current was given. Sleep quality was assessed on the day before surgery (P1) and the first and third days after surgery (D1 and D3) using the Pittsburgh Sleep Quality Index (PSQI) and Athens Insomnia Scale (AIS). Postoperative pain was assessed using visual analog scale (VAS) 72 h postoperatively. The incidences of abdominal distension, dizziness, postoperative nausea and vomiting (PONV) and pulmonary complications were recorded. Serum levels of inflammatory cytokines and the expression of key factors of oxidative stress and key molecules of the nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) signal pathway were measured.Results: EAS ameliorated sleep quality at D1 and D3 (PSQI P < 0.05, AIS P < 0.05) and decreased postoperative pain as demonstrated by lower VAS scores compared to the Sham group (P < 0.05). The incidences of abdominal distension and PONV were also lower in the TEAS group. Markers of oxidative stress were increased (P < 0.05), and the serum concentration of interleukin-6 (IL-6) was significantly lower in the TEAS group. The key mediators of the Nrf2/ARE pathway were enhanced after TEAS.Conclusion: Perioperative TEAS improved postoperative sleep quality, reduced postoperative pain and alleviated postoperative adverse effects in patients undergoing laparoscopic gastrointestinal tumor surgery resection. This may be associated with activating Nrf2/ARE signal pathway and decreasing its inflammatory actions.
C1 [Wang, Jun; Lu, Fei-Fei; Wang, Li-Wen; Jiang, Zhi-Wei] Nanjing Univ Chinese Med, Nanjing, Peoples R China.
   [Wang, Jun; Lu, Fei-Fei; Ge, Miao-Miao; Wang, Li-Wen; Wang, Gang; Gong, Guan-Wen; Liu, Xin-Xin; Jiang, Zhi-Wei] Nanjing Univ Chinese Med, Affiliated Hosp, Dept Gen Surg, Nanjing, Peoples R China.
   [Wang, Jun; Lu, Fei-Fei; Zhang, Wen-Zhuo; Ning, Fei-Long; Chen, Bao-He; Liu, Yang; Quan, Hong-Guang] Nanjing Univ Chinese Med, Xuzhou Tradit Chinese Med Hosp, Dept Gen Surg, Xuzhou, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine
RP Jiang, ZW (corresponding author), Nanjing Univ Chinese Med, Nanjing, Peoples R China.
EM surgery34@163.com
RI ; Ning, Fei-Long/GZL-3158-2022; Zhang, Wenzhuo/JQX-2899-2023
OI JIANG, Zhiwei/0009-0007-7064-5444; Liu, Xin-Xin/0000-0003-1092-236X;
   Wang, Liwen Wang/0000-0001-8136-4081; Ning,
   Fei-Long/0000-0002-8846-3709; 
FU Project of National Clinical Research Base of Traditional Chinese
   Medicine in Jiangsu Province, China [JD2022SZ18]; Xuzhou Science and
   Technology Innovation Project [KC19023, KC22181]; Key Subject Project of
   Jiangsu Province: Surgery of Traditional Chinese Medicine [js2251];
   Rapid Service Fee
FX This study was supported by Project of National Clinical Research Base
   of Traditional Chinese Medicine in Jiangsu Province, China (JD2022SZ18),
   Xuzhou Science and Technology Innovation Project (KC19023, KC22181) and
   Key Subject Project of Jiangsu Province: Surgery of Traditional Chinese
   Medicine (js2251). The Rapid Service Fee was funded by the authors.
CR Alam A, 2018, EBIOMEDICINE, V37, P547, DOI 10.1016/j.ebiom.2018.10.021
   Goes ACAD, 2014, ACTA CIR BRAS, V29, P787, DOI 10.1590/S0102-86502014001900004
   Arjmandi-Rad S, 2022, EXP BRAIN RES, V240, P3259, DOI 10.1007/s00221-022-06471-y
   Atrooz F, 2020, ADV PROTEIN CHEM STR, V119, P309, DOI 10.1016/bs.apcsb.2019.03.001
   Atrooz F, 2019, NEUROSCIENCE, V406, P22, DOI 10.1016/j.neuroscience.2019.02.021
   Bellezza I, 2018, BBA-MOL CELL RES, V1865, P721, DOI 10.1016/j.bbamcr.2018.02.010
   Besedovsky L, 2019, PHYSIOL REV, V99, P1325, DOI 10.1152/physrev.00010.2018
   Bian HT, 2020, J NEUROINFLAMM, V17, DOI 10.1186/s12974-020-01836-y
   Bishir M, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/5764017
   Chen JB, 2020, INT J SURG, V73, P57, DOI 10.1016/j.ijsu.2019.10.036
   Chen XL, 2023, DIGEST DIS SCI, V68, P98, DOI 10.1007/s10620-022-07495-8
   Chouchou F, 2014, SLEEP MED REV, V18, P273, DOI 10.1016/j.smrv.2013.07.002
   Craner JR, 2022, PAIN PRACT, V22, P171, DOI 10.1111/papr.13075
   DASILVA AMT, 1993, NEW ENGL J MED, V328, P1457, DOI 10.1056/NEJM199305203282005
   Gao Junlong, 2015, Zhongguo Zhen Jiu, V35, P269
   Gao W, 2021, SURGERY, V170, P1618, DOI 10.1016/j.surg.2021.08.007
   Gulec M, 2012, PROG NEURO-PSYCHOPH, V37, P247, DOI 10.1016/j.pnpbp.2012.02.011
   Haack M, 2020, NEUROPSYCHOPHARMACOL, V45, P205, DOI 10.1038/s41386-019-0439-z
   Huang BH, 2022, BRIT J SPORT MED, V56, P718, DOI 10.1136/bjsports-2021-104046
   Imeri L, 2009, NAT REV NEUROSCI, V10, P199, DOI 10.1038/nrn2576
   Irwin MR, 2019, NAT REV IMMUNOL, V19, P702, DOI 10.1038/s41577-019-0190-z
   Irwin MR, 2016, BIOL PSYCHIAT, V80, P40, DOI 10.1016/j.biopsych.2015.05.014
   Jiang ZM, 2018, CLIN J PAIN, V34, P1126, DOI 10.1097/AJP.0000000000000645
   Kempf A, 2019, NATURE, V568, P230, DOI 10.1038/s41586-019-1034-5
   Kobayashi EH, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11624
   Kong XN, 2010, J IMMUNOL, V185, P569, DOI 10.4049/jimmunol.0902315
   Künzel H, 2020, PSYCHONEUROENDOCRINO, V120, DOI 10.1016/j.psyneuen.2020.104799
   Lao LX, 2001, J PAIN, V2, P111, DOI 10.1054/jpai.2001.19575
   Letzen JE, 2020, HUM BRAIN MAPP, V41, P581, DOI 10.1002/hbm.24824
   Li GY, 2013, EXP THER MED, V6, P699, DOI 10.3892/etm.2013.1225
   Li Q, 2019, ACTA NEUROPATHOL COM, V7, DOI 10.1186/s40478-019-0868-2
   Longo UG, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55080453
   Lu ZH, 2021, J CLIN ANESTH, V74, DOI 10.1016/j.jclinane.2021.110453
   Miller Mark W, 2018, Harv Rev Psychiatry, V26, P57, DOI 10.1097/HRP.0000000000000167
   Mollayeva T, 2016, SLEEP MED REV, V25, P52, DOI 10.1016/j.smrv.2015.01.009
   Palagini L, 2022, CNS SPECTRUMS, V27, P298, DOI 10.1017/S1092852921000018
   Petti Filomena Bangrazi, 2002, J Tradit Chin Med, V22, P104
   Pisani MA, 2020, CHEST, V157, P977, DOI 10.1016/j.chest.2019.12.003
   Rakel B, 2003, J PAIN, V4, P455, DOI 10.1067/S1526-5900(03)00780-6
   Ren XY, 2021, ENVIRON POLLUT, V269, DOI 10.1016/j.envpol.2020.116112
   RosenbergAdamsen S, 1996, BRIT J ANAESTH, V76, P552, DOI 10.1093/bja/76.4.552
   Rushworth SA, 2011, J IMMUNOL, V187, P702, DOI 10.4049/jimmunol.1004117
   Saha S, 2020, MOLECULES, V25, DOI 10.3390/molecules25225474
   Salehabadi A, 2022, ENVIRON SCI POLLUT R, V29, P55457, DOI 10.1007/s11356-022-20996-3
   Saner NJ, 2021, MOL METAB, V43, DOI 10.1016/j.molmet.2020.101110
   Soldatos CR, 2003, J PSYCHOSOM RES, V55, P263, DOI 10.1016/S0022-3999(02)00604-9
   Song BJ, 2020, NAT SCI SLEEP, V12, P809, DOI 10.2147/NSS.S270739
   Song BJ, 2021, SLEEP BREATH, V25, P571, DOI 10.1007/s11325-020-02187-x
   Spiers JG, 2019, FRONT MOL NEUROSCI, V12, DOI 10.3389/fnmol.2019.00086
   Su X, 2018, CURR OPIN ANESTHESIO, V31, P83, DOI 10.1097/ACO.0000000000000538
   Sul OJ, 2021, MOLECULES, V26, DOI 10.3390/molecules26226949
   Sun K, 2017, CLIN J PAIN, V33, P340, DOI 10.1097/AJP.0000000000000400
   Sutton EL, 2021, ANN INTERN MED, V174, pITC33, DOI 10.7326/AITC202103160
   Tu WJ, 2019, AGING DIS, V10, P637, DOI 10.14336/AD.2018.0513
   Vaccaro A, 2020, CELL, V181, P1307, DOI 10.1016/j.cell.2020.04.049
   Villafuerte G, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/234952
   Wang T, 2019, CHINESE MED J-PEKING, V132, P1582, DOI 10.1097/CM9.0000000000000279
   Wang WJ, 2020, BRAIN RES BULL, V160, P141, DOI 10.1016/j.brainresbull.2020.03.010
   Wible RS, 2018, ELIFE, V7, DOI 10.7554/eLife.31656
   Wick EC, 2017, JAMA SURG, V152, P691, DOI 10.1001/jamasurg.2017.0898
   Xiao Y, 2022, CLIN TRANSL GASTROEN, V13, DOI 10.14309/ctg.0000000000000485
   Xing RY, 2022, PAIN THER, V11, P1327, DOI 10.1007/s40122-022-00429-2
   Xue R, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02546
   Zeng YX, 2022, J CLIN GASTROENTEROL, V56, P875, DOI 10.1097/MCG.0000000000001645
   Zhang MM, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000017842
   Zielinski MR, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.853096
NR 66
TC 19
Z9 24
U1 8
U2 39
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2193-8237
EI 2193-651X
J9 PAIN THER
JI PAIN THER.
PD JUN
PY 2023
VL 12
IS 3
BP 707
EP 722
DI 10.1007/s40122-023-00493-2
EA MAR 2023
PG 16
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA G4NV7
UT WOS:000952984500001
PM 36928500
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Xu, GX
   Lei, HZ
   Zhou, YF
   Huang, LY
   Tian, H
   Zhou, Z
   Zhao, L
   Liang, FR
AF Xu, Guixing
   Lei, Hanzhou
   Zhou, Yuanfang
   Huang, Liuyang
   Tian, Hao
   Zhou, Zhuo
   Zhao, Ling
   Liang, Fanrong
TI Acupuncture for Quality of Life of Patients with Defecation Dysfunction
   after Sphincter Preserving Surgery for Rectal Cancer: A Systematic
   Review
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID LOW ANTERIOR RESECTION; POSTOPERATIVE ILEUS; ELECTROACUPUNCTURE; INPUT;
   TRIAL; BIAS
AB Purpose. To evaluate the effectiveness and safety of acupuncture for quality of life of patients with defecation dysfunction (DD) after sphincter preserving surgery for rectal cancer. Methods. We searched nine online databases from inception to July 1, 2021, and did not restrict the type of language. Then, studies were independently selected by two research team members with screening criteria and risk bias assessment, and the data were extracted. The primary outcome was Quality of Life Questionnaire-Core 29 (QLQ-CR29). The data were then synthesized using the RevMan V. 5.2 by random-effects model. Also, we used the standardized mean differences with 95% credible interval (CI) to describe the outcome of the analysis. Results. A total of 6 randomized controlled trials (RCTs) (with 439 patients) were included in the systematic review, and data from 2 RCTs (with 200 patients) were used in the meta-analysis. Five studies (83%) were judged to have a medium risk of bias, and one was at high risk of bias. For synthesis, data from two medium-risk studies found that acupuncture or electropuncture may improve the QLQ-CR29 with urination (mean difference, -0.39 points; 95% CI, -0.46 to -0.32; I-2. 34%), abdominal pain (mean difference, -0.71 points; 95%CI, -0.89 to -0.54; I-2. 9%), stool (mean difference, -0.49 points; 95% CI, -0.77 to -0.20; I-2. 57%), defecation (mean difference, -0.59 points; 95% CI, -0.85 to -0.33; I-2. 51%), sexual function (mean difference, 0.93 points; 95% CI, 0.48 to 1.38; I-2. 90%), and self-feelings (mean difference, 1.04 points; 95% CI, 0.36 to 1.73; I-2. 94%). Conclusion. Findings in this study indicate that acupuncture or electropuncture may be effective and safe for DD, but the quality of included studies was very low. So, more large-scale, multicenter, long-term, and high-quality original research is still expected in the future.
C1 [Xu, Guixing; Lei, Hanzhou; Zhou, Yuanfang; Huang, Liuyang; Tian, Hao; Zhou, Zhuo; Zhao, Ling; Liang, Fanrong] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Zhao, L; Liang, FR (corresponding author), Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
EM zhaoling@cdutcm.edu.cn; acuresearch@126.com
OI Zhao, Ling/0000-0002-3955-0072; Tian, Hao/0000-0002-9823-0749
FU National Natural Science Foundation of China [81590950]; Key Research
   and Development Program of Science and Technology Department of Sichuan
   Province [20ZDYF1199]
FX This study was supported by grants from the National Natural Science
   Foundation of China (81590950) and Key Research and Development Program
   of Science and Technology Department of Sichuan Province (no.
   20ZDYF1199).
CR [Anonymous], 2011, The cochrane Collaboration's tool for assessing risk of bias in randomised trials
   Cancer UK, 2012, CANCERSTATS CANC STA
   CHALMERS TC, 1983, NEW ENGL J MED, V309, P1358, DOI 10.1056/NEJM198312013092204
   Chapman SJ, 2017, DIS COLON RECTUM, V60, P240, DOI 10.1097/DCR.0000000000000649
   Cooke HJ, 2000, ANN NY ACAD SCI, V915, P77
   Deng G, 2013, ANN SURG ONCOL, V20, P1164, DOI 10.1245/s10434-012-2759-7
   Dennett ER, 1999, DIS COLON RECTUM, V42, P804, DOI 10.1007/BF02236940
   Finniss DG, 2010, LANCET, V375, P686, DOI 10.1016/S0140-6736(09)61706-2
   Fujii S, 2014, SURG ENDOSC, V28, P466, DOI 10.1007/s00464-013-3223-x
   Gershon MD, 2002, FASEB J, V16, pA28
   Guyatt GH, 2008, BRIT MED J, V336, P924, DOI 10.1136/bmj.39489.470347.AD
   Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928
   Hou L, 2017, Zhonghua Yi Xue Za Zhi, V97, P3492, DOI 10.3760/cma.j.issn.0376-2491.2017.44.012
   Juul T, 2014, DIS COLON RECTUM, V57, P585, DOI 10.1097/DCR.0000000000000116
   Juul T, 2014, ANN SURG, V259, P728, DOI 10.1097/SLA.0b013e31828fac0b
   Liu F., 2015, BIOFEEDBACK ACUPUNCT
   Lundgren O, 2000, GUT, V47, P33
   Meng ZQ, 2010, WORLD J GASTROENTERO, V16, P104, DOI 10.3748/wjg.v16.i1.104
   Ng SSM, 2013, GASTROENTEROLOGY, V144, P307, DOI 10.1053/j.gastro.2012.10.050
   Paterson C, 2005, BMJ-BRIT MED J, V330, P1202, DOI 10.1136/bmj.330.7501.1202
   Pildal J, 2005, BMJ-BRIT MED J, V330, P1049, DOI 10.1136/bmj.38414.422650.8F
   Powley TL, 2000, GUT, V47, P30
   Schulz KF, 2010, BMJ-BRIT MED J, V340, DOI [10.1136/bmj.c869, 10.1136/bmj.c332]
   SCHULZ KF, 1995, JAMA-J AM MED ASSOC, V274, P1456
   SCHULZ KF, 1995, JAMA-J AM MED ASSOC, V273, P408, DOI 10.1001/jama.273.5.408
   Siegel RL., 2017, CA-CANCER J CLIN, V67, P177, DOI DOI 10.3322/caac.21395
   Vader, 1998, BMJ, V317, P1258
   Wang Y, 2019, J Clin Acupunct Moxibust, V35, P26, DOI DOI 10.3969/J.ISSN.1005-0779.2019.04.008
   WILLIAMSON MER, 1994, DIS COLON RECTUM, V37, P1228, DOI 10.1007/BF02257786
   Xia H., 2019, ZHEJIANG J INTEGRATE, V54, P291
   Xia Y, 2018, CHINA MODERN DOCTOR, V56, P146
   Xiao Y, 2017, STUDY BIOFEEDBACK AC
   Xu GX, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-034152
   Xu Y., 2013, DEV OWING ACUPUNCTUR
   Yu S, 2011, MODERN J INTEGRATED, V20
   [赵加应 Zhao Jiaying], 2020, [中国康复理论与实践, Chinese Journal of Rehabilitation Theory and Practice], V26, P715
   Zhao JY, 2018, ACUPUNCTURE ELECTRO, V43, P103, DOI 10.3727/036012918X15353852193131
NR 37
TC 4
Z9 6
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD DEC 15
PY 2021
VL 2021
AR 7858252
DI 10.1155/2021/7858252
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 5E7PT
UT WOS:000865816000004
PM 34956383
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Papadopoulou, M
   Stamou, M
   Bakalidou, D
   Moschovos, C
   Zouvelou, V
   Zis, P
   Tzartos, J
   Chroni, E
   Michopoulos, I
   Tsivgoulis, G
AF Papadopoulou, Marianna
   Stamou, Magda
   Bakalidou, Daphne
   Moschovos, Christos
   Zouvelou, Vasiliki
   Zis, Panagiotis
   Tzartos, John
   Chroni, Elisabeth
   Michopoulos, Ioannis
   Tsivgoulis, Georgios
TI Non-pharmacological Interventions on Pain and Quality of Life in
   Chemotherapy Induced Polyneuropathy: Systematic Review and Meta-Analysis
SO IN VIVO
LA English
DT Review
DE Chemotherapy-induced polyneuropathy; non-pharmacological interventions;
   pain; quality of life; acupuncture; yoga; review
ID INDUCED PERIPHERAL NEUROPATHY; CANCER-PATIENTS; EXERCISE; ACUPUNCTURE;
   BALANCE
AB Background/Aim: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment, resulting in pain, numbness, instability, and thus affecting quality of life (QoL), occasionally leading to discontinuation of chemotherapy. Pharmacological treatments are not sufficient. Non-pharmacological interventions (NPIs) have also been tried. This study aimed to systematically review the efficacy of NPIs on pain and QoL in patients suffering from CIPN. Materials and Methods: The databases searched were Pubmed, Cohrane, and Scopus for randomized controlled trials (RCTs) published in the last 5 years (2017-2022). Studies were considered eligible, if they assessed adult patients suffering from CIPN because of any chemotherapeutic drug for any type and any stage of cancer and if study protocols included non pharmacological intervention with a structured protocol. Results: A total of 1,496 records were identified. Finally, 10 RCTs including 495 patients (253 in the intervention group and 242 in the control group) were included for meta-analysis. Intervention protocols included acupuncture (n=6), exercise (n=3), and yoga (n=1). NPIs significantly reduced neuropathic pain. However, the effect on QoL was not significant. Conclusion: NPIs are beneficial in the treatment of pain in patients with CIPN but their impact on QoL is not statistically supported. Larger sample sizes, more homogenous in outcome measures and interventions are needed to further explore NPIs' efficacy on CIPN symptoms.
C1 [Papadopoulou, Marianna; Stamou, Magda; Bakalidou, Daphne; Zouvelou, Vasiliki] Univ West Attica, Dept Physiotherapy, Athens, Greece.
   [Papadopoulou, Marianna; Moschovos, Christos; Zis, Panagiotis; Tzartos, John; Tsivgoulis, Georgios] Natl & Kapodistrian Univ Athens, Attikon Univ Gen Hosp, Med Sch, Dept Neurol 2, Athens, Greece.
   [Zouvelou, Vasiliki; Michopoulos, Ioannis] Natl & Kapodistrian Univ Athens, Eginit Univ Hosp, Sch Med, Dept Neurol 1, Athens, Greece.
   [Chroni, Elisabeth] Univ Patras, Sch Med, Dept Neurol, Patras, Greece.
   [Michopoulos, Ioannis] Natl & Kapodistrian Univ Athens, Attikon Univ Gen Hosp, Med Sch, Dept Psychiat 2, Athens, Greece.
   [Papadopoulou, Marianna] Univ West Attica, Physiotherapy Dept, 28 Ag Spyridonos, Athens 12243, Greece.
C3 University of West Attica; National & Kapodistrian University of Athens;
   University Hospital Attikon; National & Kapodistrian University of
   Athens; University of Patras; University Hospital Attikon; National &
   Kapodistrian University of Athens; University of West Attica
RP Papadopoulou, M (corresponding author), Univ West Attica, Physiotherapy Dept, 28 Ag Spyridonos, Athens 12243, Greece.
EM marpapgr@yahoo.co.uk
RI stamou, magda/ACY-0491-2022; Tzartos, John/NXC-3452-2025; Zis,
   Panagiotis/AAH-8027-2021; Tsivgoulis, Georgios/AAD-7467-2019;
   PAPADOPOULOU, MARIANNA/AAP-5027-2021
OI stamou, magda/0000-0002-1856-9006; PAPADOPOULOU,
   MARIANNA/0000-0002-0163-7455
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   [Anonymous], 2020, J PHYSIOTHER, V66, P59, DOI 10.1016/j.jphys.2019.08.005
   [Anonymous], ECOG PERF STAT
   [Anonymous], 2020, PEDRO
   [Anonymous], FACT GOG NTX
   Bao T, 2021, ONCOLOGIST, V26, pE2070, DOI 10.1002/onco.13933
   Bao T, 2020, JNCI CANCER SPECT, V4, DOI 10.1093/jncics/pkaa048
   Belavy DL, 2021, NEUROSCI BIOBEHAV R, V120, P100, DOI 10.1016/j.neubiorev.2020.11.012
   Brayall P, 2018, REHABIL ONCOL, V36, P161, DOI 10.1097/01.REO.0000000000000111
   Brozou V, 2018, PAIN THER, V7, P105, DOI 10.1007/s40122-017-0092-3
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Colvin LA, 2019, PAIN, V160, pS1, DOI 10.1097/j.pain.0000000000001540
   D'Alessandro EG, 2022, BMJ SUPPORT PALLIAT, V12, P64, DOI 10.1136/bmjspcare-2018-001542
   Dhawan S, 2020, CANCER NURS, V43, P269, DOI 10.1097/NCC.0000000000000693
   Duregon F, 2018, CRIT REV ONCOL HEMAT, V121, P90, DOI 10.1016/j.critrevonc.2017.11.002
   Franco KFM, 2021, EUR J PAIN, V25, P51, DOI 10.1002/ejp.1666
   Geneen LJ, 2017, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD011279.pub2, 10.1002/14651858.CD011279.pub3]
   Girach A, 2019, PAIN RES MANAG, V2019, DOI 10.1155/2019/2091960
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Hou S, 2018, PAIN PHYSICIAN, V21, P571, DOI 10.36076/ppj.2018.6.571
   Iravani S, 2020, PAIN RES MANAG, V2020, DOI 10.1155/2020/2504674
   Jin YX, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8875433
   Li K, 2019, CURR ONCOL, V26, pE147, DOI 10.3747/co.26.4261
   Liampas A, 2021, PAIN THER, V10, P55, DOI 10.1007/s40122-020-00210-3
   Liampas A, 2020, ADV THER, V37, P4096, DOI 10.1007/s12325-020-01462-3
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Molassiotis A, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419836501
   RevMan, ABOUT US
   Saraboon C, 2021, J BODYW MOV THER, V28, P164, DOI 10.1016/j.jbmt.2021.07.013
   SF, CHEM IND POL NONPH M
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Yuan QL, 2016, SCI REP-UK, V6, DOI 10.1038/srep30675
   Zimmer P, 2018, SUPPORT CARE CANCER, V26, P615, DOI 10.1007/s00520-017-3875-5
NR 35
TC 24
Z9 26
U1 1
U2 11
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD JAN-FEB
PY 2023
VL 37
IS 1
BP 47
EP 56
DI 10.21873/invivo.13053
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA L8QX3
UT WOS:001025866500005
PM 36593011
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Berberian, P
   Obimba, C
   Glickman-Simon, R
   Sethi, T
AF Berberian, Peter
   Obimba, Chinyere
   Glickman-Simon, Richard
   Sethi, Tanmeet
TI HERBS FOR LOW-BACK PAIN, ACUPUNCTURE FOR PSYCHOLOGICAL DISTRESS,
   OSTEOPATHIC MANIPULATIVE THERAPY FOR CHRONIC MIGRAINE, HONEY DRESSINGS
   FOR BURNS, VEGETARIAN DIET AND RISK OF COLORECTAL CANCER
SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
LA English
DT Editorial Material
ID PRIMARY-CARE PATIENTS; HEADACHE IMPACT; CONVENTIONAL TREATMENT;
   INTEGRATIVE TREATMENT; TOPICAL APPLICATION; GENERAL-POPULATION;
   PREVALENCE; DEPRESSION; MEAT; COMPLEMENTARY
C1 [Glickman-Simon, Richard] Tufts Univ, Sch Med, Publ Hlth & Family Med, Boston, MA 02111 USA.
   [Glickman-Simon, Richard] DynaMed, Ipswich, MA USA.
   [Sethi, Tanmeet] Swedish Cherry Hill Family Med Residency Program, Seattle, WA USA.
C3 Tufts University; Swedish Health Services
CR [Anonymous], 2011, CONT UPD PROJ REP FO
   [Anonymous], About Colorectal Cancer
   [Anonymous], 2007, FOOD NUTR PHYS ACT P
   [Anonymous], Integrating mental health into primary care: A Global perspective
   [Anonymous], 2014, COCHRANE DATABASE SY
   [Anonymous], 1997, BEE PRODUCTS PROPERT
   [Anonymous], 2002, HEART VIEWS
   [Anonymous], CEPHALALGIA, DOI DOI 10.1177/0333102413485658
   [Anonymous], COCHRANE DATABASE SY
   Arvidsdotter T, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-210
   Arvidsdotter T, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-308
   Astin JA, 2002, CEPHALALGIA, V22, P617, DOI 10.1046/j.1468-2982.2002.00423.x
   BERGMAN A, 1983, AM J SURG, V145, P374, DOI 10.1016/0002-9610(83)90204-0
   Blumenthal Mark., 1998, COMPLETE GERMAN COMM
   Cerritelli F, 2015, COMPLEMENT THER MED, V23, P149, DOI 10.1016/j.ctim.2015.01.011
   Chan DSM, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0027218, 10.1371/journal.pone.0020456]
   Chrubasik S, 1999, EUR J ANAESTH, V16, P118
   Chrubasik S, 2010, PHYTOTHER RES, V24, P1877, DOI 10.1002/ptr.3335
   Chrubasik S, 1996, PHYTOMEDICINE, V3, P1, DOI 10.1016/S0944-7113(96)80003-1
   Chrubasik S, 2000, AM J MED, V109, P9, DOI 10.1016/S0002-9343(00)00442-3
   Coeytaux RR, 2006, J CLIN EPIDEMIOL, V59, P374, DOI 10.1016/j.jclinepi.2005.05.010
   Cross AJ, 2007, PLOS MED, V4, P1973, DOI 10.1371/journal.pmed.0040325
   Cross AJ, 2010, CANCER RES, V70, P2406, DOI 10.1158/0008-5472.CAN-09-3929
   Cuijpers P, 2002, J AFFECT DISORDERS, V72, P227, DOI 10.1016/S0165-0327(01)00413-X
   Daly EJ, 2010, ANN CLIN PSYCHIATRY, V22, P43
   Deyo RA, 2006, SPINE, V31, P2724, DOI 10.1097/01.brs.0000244618.06877.cd
   Eisenberg DM, 2012, J ALTERN COMPLEM MED, V18, P354, DOI 10.1089/acm.2011.0408
   Frass M, 2012, OCHSNER J, V12, P45
   Frerick H, 2003, PAIN, V106, P59, DOI 10.1016/S0304-3959(03)00278-1
   Fu XB, 2001, WOUND REPAIR REGEN, V9, P2, DOI 10.1046/j.1524-475x.2001.00002.x
   Gagnier Joel J, 2004, BMC Complement Altern Med, V4, P13, DOI 10.1186/1472-6882-4-13
   Grabois M, 2005, AM J PHYS MED REHAB, V84, pS29, DOI 10.1097/01.PHM.0000154908.76436.C2
   Johnson A, 1992, Ostomy Wound Manage, V38, P36
   Jull AB, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005083.pub4
   Jull AB, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005083.pub2
   Keitel WG, 2001, ARZNEIMITTELFORSCH, V51, P896
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kessler RC, 2001, AM J PSYCHIAT, V158, P289, DOI 10.1176/appi.ajp.158.2.289
   Key TJ, 2009, AM J CLIN NUTR, V89, pS1620, DOI 10.3945/ajcn.2009.26736M
   Kosinski M, 2003, QUAL LIFE RES, V12, P963, DOI 10.1023/A:1026119331193
   Lawler SP, 2006, ANN BEHAV MED, V32, P50, DOI 10.1207/s15324796abm3201_6
   Lisspers J, 1997, ACTA PSYCHIAT SCAND, V96, P281, DOI 10.1111/j.1600-0447.1997.tb10164.x
   Molan P, 2001, BEE WORLD, V82, P22, DOI 10.1080/0005772X.2001.11099498
   Norat T, 2005, J NATL CANCER I, V97, P906, DOI 10.1093/jnci/dji164
   Orlich MJ, 2015, JAMA INTERN MED, V175, P767, DOI 10.1001/jamainternmed.2015.59
   Oryan A, 1998, J VET MED A, V45, P181, DOI 10.1111/j.1439-0442.1998.tb00815.x
   Robinson KL, 2004, ANN EPIDEMIOL, V14, P467, DOI 10.1016/j.annepidem.2003.11.007
   Stovner LJ, 2007, CEPHALALGIA, V27, P193, DOI 10.1111/j.1468-2982.2007.01288.x
   Tantamango-Bartley Y, 2013, CANCER EPIDEM BIOMAR, V22, P286, DOI 10.1158/1055-9965.EPI-12-1060
   Voigt K, 2011, J ALTERN COMPLEM MED, V17, P225, DOI 10.1089/acm.2009.0673
   Wasiak J, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002106.pub4
   Yang M, 2011, CEPHALALGIA, V31, P357, DOI 10.1177/0333102410379890
NR 52
TC 2
Z9 3
U1 1
U2 37
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-8307
EI 1878-7541
J9 EXPLORE-NY
JI Explore-J Sci. Heal.
PD SEP-OCT
PY 2015
VL 11
IS 5
BP 410
EP 414
DI 10.1016/j.explore.2015.07.011
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CQ7JT
UT WOS:000360780500012
PM 26238168
DA 2026-01-16
ER

PT J
AU Yang, EM
   Lu, WD
   Giobbie-Hurder, A
   Shin, IH
   Chen, WY
   Block, CC
   Partridge, A
   Jeselsohn, RM
   Tolaney, SM
   Freedman, RA
   Ligibel, JA
AF Yang, EunMee
   Lu, Weidong
   Giobbie-Hurder, Anita
   Shin, Im Hee
   Chen, Wendy Y.
   Block, Caroline C.
   Partridge, Ann
   Jeselsohn, Rinath M.
   Tolaney, Sara M.
   Freedman, Rachel A.
   Ligibel, Jennifer A.
TI Auricular Acupuncture During Chemotherapy Infusion in Breast Cancer
   Patients: A Feasibility Study
SO JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE auricular acupuncture; breast cancer; chemotherapy; symptom management;
   feasibility study
ID SYMPTOM BURDEN CLUSTERS; ANXIETY; CARE; TRAJECTORIES; PREVALENCE;
   VALIDATION; FATIGUE; WOMEN; STATE; PAIN
AB Introduction: Breast cancer patients undergoing chemotherapy experience multiple distressing symptoms. The authors investigated the feasibility and potential benefits of auricular acupuncture during chemotherapy infusion in this population.Materials and Methods: Women with stage I-III breast cancer undergoing chemotherapy were enrolled and followed for three chemotherapy cycles. During the first cycle of chemotherapy that participants received after study enrollment, they were provided with educational materials. During the second and third cycles of chemotherapy after enrollment, they received auricular acupuncture. The primary outcome was feasibility, assessed by recruitment, retention, and completion of assessments. Secondary outcomes included symptom burden (Edmonton Symptom Assessment System-Revised Version) and anxiety (State-Trait Anxiety Inventory-State), assessed at four timepoints for each cycle: day 1, pre-education/acupuncture (T1); day 1, post-education/acupuncture (T2); day 2 (T3); and day 5 (T4). Nausea and vomiting (Multinational Association of Supportive Care in Cancer [MASCC] Antiemesis Tool) were assessed on days 2 and 5. Paired t test was used to compare patient-reported outcomes during cycle 1 (education) versus an average of outcomes during cycles 2 and 3 (acupuncture).Results: Twenty-six patients were enrolled, of which 24 completed all acupuncture sessions and 22 completed all outcome assessments. In cycles 2 and 3 versus cycle 1, participants experienced significant reductions in symptom burden (change from T1 to T4: -7.9 +/- 13.6, p = 0.02), anxiety (change from T1 to T2: -3.3 +/- 6.5, p = 0.02), and nausea severity on day 2 (-1.3 +/- 2.6, p = 0.04).Conclusions: The delivery of auricular acupuncture during chemotherapy infusion was feasible and associated with reduction of symptom burden, anxiety, and nausea in breast cancer patients. Larger-scale clinical studies are needed to confirm these findings.Clinical Trial Registration number: NCT03170648.
C1 [Yang, EunMee; Lu, Weidong; Chen, Wendy Y.; Block, Caroline C.; Partridge, Ann; Jeselsohn, Rinath M.; Tolaney, Sara M.; Freedman, Rachel A.; Ligibel, Jennifer A.] Dana Farber Canc Inst, Dept Med Oncol, 450 Brookline Ave,SW121A, Boston, MA 02115 USA.
   [Giobbie-Hurder, Anita] Dana Farber Canc Inst, Dept Data Sci, Div Biostat, Boston, MA 02115 USA.
   [Shin, Im Hee] Daegu Catholic Univ, Sch Med, Dept Med Stat & Informat, Daegu, South Korea.
C3 Harvard University; Harvard University Medical Affiliates; Dana-Farber
   Cancer Institute; Harvard University; Harvard University Medical
   Affiliates; Dana-Farber Cancer Institute; Catholic University of Daegu
RP Lu, WD (corresponding author), Dana Farber Canc Inst, Dept Med Oncol, 450 Brookline Ave,SW121A, Boston, MA 02115 USA.
EM weidong_lu@dfci.harvard.edu
RI Giobbie-Hurder, Anita/JNR-8667-2023; Tolaney, S/AFZ-2612-2022
OI Giobbie-Hurder, Anita/0000-0003-2496-7737; 
CR Aapro M, 2018, SUPPORT CARE CANCER, V26, pS5, DOI 10.1007/s00520-018-4131-3
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Ambroggi M, 2015, ONCOLOGIST, V20, P1378, DOI 10.1634/theoncologist.2015-0110
   [Anonymous], HEMATOL ONCOL CLIN N
   [Anonymous], 2011, J CANC SCI THER, DOI [10.4172/1948-5956.s2-001, DOI 10.4172/1948-5956.S2-001]
   Arai YCP, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/945063
   Arai YCP, 2010, EVID-BASED COMPL ALT, V7, P383, DOI 10.1093/ecam/nep172
   Boltong A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103512
   Booth Christopher M, 2007, J Support Oncol, V5, P374
   Brauer JA, 2010, J ALTERN COMPLEM MED, V16, P183, DOI 10.1089/acm.2009.0354
   Browall M, 2017, SUPPORT CARE CANCER, V25, P1423, DOI 10.1007/s00520-016-3527-1
   Bruera E, 1991, J Palliat Care, V7, P6
   Bubis LD, 2018, J CLIN ONCOL, V36, P1103, DOI 10.1200/JCO.2017.76.0876
   Byar KatherineL., 2006, ONCOL NURS FORUM, V33, pE18, DOI [DOI 10.1188/06.ONF.E18-E26, 10.1188/06.ONF.E18-E26]
   Cakmak YO, 2019, FRONT HUM NEUROSCI, V13, DOI 10.3389/fnhum.2019.00421
   Carter K, 2017, BEHAV SCI BASEL, V16, P7
   Chad-Friedman E, 2017, CANCER-AM CANCER SOC, V123, P3882, DOI 10.1002/cncr.30904
   Chang VT, 2000, CANCER, V88, P2164, DOI 10.1002/(SICI)1097-0142(20000501)88:9<2164::AID-CNCR24>3.0.CO;2-5
   Charalambous A, 2017, SAGE OPEN MED, V5, DOI 10.1177/2050312117717507
   Chen HY, 2007, J ALTERN COMPLEM MED, V13, P669, DOI 10.1089/acm.2006.6400
   Cheng Alex C, 2017, AMIA Annu Symp Proc, V2017, P555
   Cleeland Charles S, 2007, J Natl Cancer Inst Monogr, P16
   de Ligt KM, 2019, BREAST CANCER RES TR, V178, P703, DOI 10.1007/s10549-019-05433-3
   Deadman P., 2007, A Manual of Acupuncture
   Deshields T, 2014, SUPPORT CARE CANCER, V22, P1089, DOI 10.1007/s00520-013-2049-3
   Dibble Suzanne L, 2003, Oncol Nurs Forum, V30, pE40, DOI 10.1188/03.ONF.E40-E47
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Hashemi SM, 2020, BREAST CANCER-TOKYO, V27, P166, DOI 10.1007/s12282-019-01031-9
   He W, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/786839
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hsu HT, 2017, J PAIN SYMPTOM MANAG, V53, P1017, DOI 10.1016/j.jpainsymman.2016.12.354
   Hui D, 2017, J PAIN SYMPTOM MANAG, V53, P630, DOI 10.1016/j.jpainsymman.2016.10.370
   Hui D, 2016, J PAIN SYMPTOM MANAG, V51, P262, DOI 10.1016/j.jpainsymman.2015.10.004
   Jagsi R, 2017, CANCER-AM CANCER SOC, V123, P4791, DOI 10.1002/cncr.30959
   Jim HSL, 2011, ANN BEHAV MED, V42, P321, DOI 10.1007/s12160-011-9294-9
   Julian LJ, 2011, ARTHRIT CARE RES, V63, pS467, DOI 10.1002/acr.20561
   Kawakita K, 2014, BIOPSYCHOSOC MED, V8, DOI 10.1186/1751-0759-8-4
   Kelly C, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-013059
   Lee IS, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/1304152
   Lopez G, 2018, J CANCER, V9, P3613, DOI 10.7150/jca.26527
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Mao JJ, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-7
   Michalek-Sauberer A, 2012, CLIN ORAL INVEST, V16, P1517, DOI 10.1007/s00784-011-0662-4
   Molassiotis A, 2007, J PAIN SYMPTOM MANAG, V34, P148, DOI 10.1016/j.jpainsymman.2006.10.018
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   National Cancer Institute, 2016, CHEM YOU SUPP PEOPL
   Nersesyan H., 2007, THER CLIN RISK MANAG, V3, P381
   Reilly CM, 2013, SUPPORT CARE CANCER, V21, P1525, DOI 10.1007/s00520-012-1688-0
   Rocque GB, 2020, CANCER MED-US, V9, P8423, DOI 10.1002/cam4.3461
   Sarenmalm EK, 2014, J PAIN SYMPTOM MANAG, V47, P731, DOI 10.1016/j.jpainsymman.2013.05.012
   Schneider A, 2016, EUR J ONCOL NURS, V24, P1, DOI 10.1016/j.ejon.2016.07.001
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   TAN JY, 2014, EVID-BASED COMPL ALT, V2014
   Wang T, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/5645632
   Wirz-Ridolfi A, 2019, MED ACUPUNCT, V31, P145, DOI 10.1089/acu.2019.1349
   Yuemei Li, 2006, J Tradit Chin Med, V26, P163
   Zia FZ, 2017, J NATL CANC I MONOGR, V2017, plgx005
NR 57
TC 2
Z9 4
U1 2
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2768-3605
EI 2768-3613
J9 J INTEGR COMPLEMENT
JI J. Integr. Complement. Med.
PD MAY 1
PY 2022
VL 28
IS 5
BP 427
EP 435
DI 10.1089/jicm.2021.0256
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 1G6NL
UT WOS:000795963000008
PM 35238615
DA 2026-01-16
ER

PT J
AU Bao, T
   Goloubeva, O
   Pelser, C
   Porter, N
   Primrose, J
   Hester, L
   Sadowska, M
   Lapidus, R
   Medeiros, M
   Lao, LX
   Dorsey, SG
   Badros, AZ
AF Bao, Ting
   Goloubeva, Olga
   Pelser, Colleen
   Porter, Neil
   Primrose, James
   Hester, Lisa
   Sadowska, Mariola
   Lapidus, Rena
   Medeiros, Michelle
   Lao, Lixing
   Dorsey, Susan G.
   Badros, Ashraf Z.
TI A Pilot Study of Acupuncture in Treating Bortezomib-Induced Peripheral
   Neuropathy in Patients With Multiple Myeloma
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; bortezomib; peripheral neuropathy; multiple myeloma
ID CYTOKINE PRODUCTION; PHASE-III; PAIN; NEUROTOXICITY; SCORE;
   REVERSIBILITY; VALIDATION; ASTHMA; GROWTH; TRIAL
AB Background. Peripheral neuropathy is the dose limiting toxicity of bortezomib in patients with multiple myeloma (MM). Objectives. To examine the safety, feasibility and efficacy of acupuncture in reducing bortezomib-induced peripheral neuropathy (BIPN) symptoms. Methods. Patients with MM experiencing persistent BIPN >= grade 2 despite adequate medical intervention and discontinuation of bortezomib received 10 acupuncture treatments for 10 weeks (2x/week for 2 weeks, 1x/week for 4 weeks, and then biweekly for 4 weeks). Responses were assessed by the Clinical Total Neuropathy Score (TNSc), Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) questionnaire, and the Neuropathy Pain Scale (NPS). Repeated-measures analysis of variance was used to test for monotonic decline in scores on each of the measures. Serial serum levels of proinflammatory and neurotrophic cytokines were obtained at baseline and weeks 1, 2, 4, 8, and 14. Results. Twenty-seven patients with MM were enrolled in the trial. There were no adverse events associated with the acupuncture treatments. TNSc data were deemed invalid and therefore were not reported. At weeks 10 and 14, FACT/GOG-Ntx and NPS showed significant reduction suggesting decreased pain, and improved function (P values were <.0001 for both FACT/GOG-Ntx and NPS at weeks 10 and 14). However, nerve conduction studies did not significantly change between baseline assessment and end of study. There was no correlation in serum cytokines for responders versus none responders. Conclusions. Acupuncture is safe, feasible and produces subjective improvements in patients' symptoms. A follow-up randomized controlled trial is warranted.
C1 [Bao, Ting; Goloubeva, Olga; Pelser, Colleen; Porter, Neil; Primrose, James; Hester, Lisa; Sadowska, Mariola; Lapidus, Rena; Medeiros, Michelle; Lao, Lixing; Dorsey, Susan G.; Badros, Ashraf Z.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore
RP Bao, T (corresponding author), Mem Sloan Kettering Canc Ctr, Integrat Med & Breast Oncol Serv, 1429 First Ave, New York, NY 10021 USA.
EM baot@mskcc.org
RI ; Lao, Lixing/P-9107-2019
OI Bao, Ting/0000-0003-4437-2597; Lao, Lixing/0000-0003-0198-9714
FU  [NCI K12 CA126849];  [R21 CA173263];  [NINR P30NR011396]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by grants NCI K12 CA126849 and R21 CA173263 (TB) and NINR
   P30NR011396 (SGD).
CR Abuaisha BB, 1998, DIABETES RES CLIN PR, V39, P115, DOI 10.1016/S0168-8227(97)00123-X
   Ahn Andrew C, 2007, Acupunct Med, V25, P11
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Argyriou AA, 2008, BLOOD, V112, P1593, DOI 10.1182/blood-2008-04-149385
   Arnulf B, 2012, HAEMATOL-HEMATOL J, V97, P1925, DOI 10.3324/haematol.2012.067793
   Arrieta O, 2011, NEUROLOGY, V77, P987, DOI 10.1212/WNL.0b013e31822e045c
   Badros A, 2007, CANCER-AM CANCER SOC, V110, P1042, DOI 10.1002/cncr.22921
   Bao T, 2012, MED ACUPUNCT, V24, P181, DOI 10.1089/acu.2011.0868
   Bao T, 2011, PAIN RES TREAT, V2011, DOI 10.1155/2011/920807
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Beijing College of Traditional Chinese Medicine, 1979, ESS CHIN AC
   Calhoun EA, 2003, INT J GYNECOL CANCER, V13, P741, DOI 10.1111/j.1525-1438.2003.13603.x
   Cata JP, 2007, J PAIN, V8, P296, DOI 10.1016/j.jpain.2006.09.014
   Cavaletti G, 2006, J PERIPHER NERV SYST, V11, P135, DOI 10.1111/j.1085-9489.2006.00078.x
   Cavaletti G, 2007, J PERIPHER NERV SYST, V12, P210, DOI 10.1111/j.1529-8027.2007.00141.x
   Cavaletti G, 2010, LEUKEMIA LYMPHOMA, V51, P1178, DOI 10.3109/10428194.2010.483303
   Cornblath DR, 1999, NEUROLOGY, V53, P1660, DOI 10.1212/WNL.53.8.1660
   Fishbain DA, 2008, PAIN MED, V9, P149, DOI 10.1111/j.1526-4637.2007.00302.x
   Galantino MLA, 1999, J ALTERN COMPLEM MED, V5, P135, DOI 10.1089/acm.1999.5.135
   Galer BS, 1997, NEUROLOGY, V48, P332, DOI 10.1212/WNL.48.2.332
   Henry NL, 2011, CANCER-AM CANCER SOC, V117, P5469, DOI 10.1002/cncr.26230
   Hideshima T, 2001, CANCER RES, V61, P3071
   Jensen MP, 2006, CLIN J PAIN, V22, P97, DOI 10.1097/01.ajp.0000173018.64741.62
   Jeong HJ, 2003, AM J CHINESE MED, V31, P945, DOI 10.1142/S0192415X03001661
   Jeong HJ, 2002, IMMUNOPHARM IMMUNOT, V24, P265, DOI 10.1081/IPH-120003759
   Joos S, 2000, J ALTERN COMPLEM MED, V6, P519, DOI 10.1089/acm.2000.6.519
   Manni L, 2011, ARCH ITAL BIOL, V149, P247, DOI 10.4449/aib.v149i2.1365
   Petti Filomena Bangrazi, 2002, J Tradit Chin Med, V22, P104
   Qiu M L., 1993, Chinese Acupuncture and Moxibustion
   Richardson PG, 2006, J CLIN ONCOL, V24, P3113, DOI 10.1200/JCO.2005.04.7779
   Richardson PG, 2009, BRIT J HAEMATOL, V144, P895, DOI 10.1111/j.1365-2141.2008.07573.x
   Schröder S, 2007, EUR J NEUROL, V14, P276, DOI 10.1111/j.1468-1331.2006.01632.x
   Shi Q, 2013, J CLIN ONCOL S, V31
   Thacker MA, 2007, ANESTH ANALG, V105, P838, DOI 10.1213/01.ane.0000275190.42912.37
   Vincent C, 2001, BRIT MED J, V323, P467, DOI 10.1136/bmj.323.7311.467
   Wang XM, 2012, CYTOKINE, V59, P3, DOI 10.1016/j.cyto.2012.03.027
   Wong Raimond, 2006, Acupunct Med, V24, P87
   Wu HG, 1999, WORLD J GASTROENTERO, V5, P515
   Zhou YH, 2009, AM J CLIN ONCOL-CANC, V32, P319, DOI 10.1097/COC.0b013e318173a520
NR 39
TC 45
Z9 52
U1 0
U2 24
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD SEP
PY 2014
VL 13
IS 5
BP 396
EP 404
DI 10.1177/1534735414534729
PG 9
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA AN6QB
UT WOS:000340719500003
PM 24867959
OA gold
DA 2026-01-16
ER

PT J
AU Yin, J
   Feng, MM
   Xu, HY
AF Yin, Jie
   Feng, Mengmeng
   Xu, Haiyang
TI Cai's gynecology chronic pelvic formula with acupuncture alleviates
   chronic pelvic pain and reduces recurrence in patients with pelvic
   inflammatory disease sequelae
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Cai's gynecology chronic pelvic formula; acupuncture; chronic pelvic
   pain; recurrence rate; clinical efficacy; cox regression analysis
AB Objective: To assess the efficacy of Cai's Gynecology Chronic Pelvic Formula combined with acupuncture in managing chronic pelvic pain (CPP) secondary to pelvic inflammatory disease (PID) sequelae, and its effect on recurrence. Methods: A retrospective study assessed medical records from 240 CPP patients undergoing treatment between February 2019 and February 2024. Patients were divided into a control group (standard treatment, n = 120) and an observation group (standard treatment plus Cai's Chronic Pelvic Formula combined with acupuncture, n = 120), with treatment lasted for 28 days and follow-up for 6 months. The symptom scores (Visual Analog Scale, Self-rating Anxiety Scale and Self-rating Depression Scale), inflammatory markers [C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cancer antigen 125 (CA125)], efficacy rates, and recurrence rates were all employed to measure treatment outcomes. Cox regression was leveraged to identify recurrence risk factors, while a nomogram model was developed and validated by Receiver Operating Characteristic (ROC), calibration curves, and decision curve analysis (DCA). Results: The observation group had significantly lower post-treatment Traditional Chinese Medicine symptom scores, inflammatory markers (CRP: P < 0.001; TNF-alpha: P = 0.003; IL-6: P = 0.004), and CA125 (P < 0.001) versus the control group. The observation group also demonstrated shorter symptom resolution time (P < 0.05), with higher total treatment efficacy in comparison to the control group (93.46% vs. 79.70%; P = 0.002). In addition, the observation group showed lower recurrence rates (14.2% vs. 28.3%; P = 0.008) as well as postponed recurrence time when compared to the control group. Cox regression analysis identified treatment protocol (HR = 0.41, 95% CI: 0.24-0.71), disease duration (HR = 1.32, 95% CI: 1.08-1.62), and pre-treatment CRP level (HR = 1.18, 95% CI: 1.02-1.36) as independent recurrence predictors. In addition, the nomogram demonstrated high accuracy in predicting disease recurrence (C-index = 0.852), with both ROC (AUC = 0.837) and calibration curves confirming its reliability. DCA indicated high clinical net benefit of the studying treatment protocol. Conclusion: Cai's Gynecology Chronic Pelvic Formula combined with acupuncture could significantly alleviate CPP and inflammation, and decrease recurrence rates. The nomogram may be used as a validated tool for predicting the disease recurrence, with benefits when integrated into clinical practice as a novel therapeutic strategy.
C1 [Yin, Jie] Shangluo Tradit Chinese Med Hosp, Dept Gynaecol, 148 Beixin St, Shangluo 726000, Shaanxi, Peoples R China.
   [Feng, Mengmeng] Shangluo Vocat & Tech Coll, Tradit Chinese Med Teaching & Res Off, West Sect Shangyang Ave, Shangluo 726000, Shaanxi, Peoples R China.
   [Xu, Haiyang] Xian Int Med Ctr Hosp, Dept Postpartum & Pelv Floor Rehabil, 777 Xitai Rd, Xian 710100, Shaanxi, Peoples R China.
RP Xu, HY (corresponding author), Xian Int Med Ctr Hosp, Dept Postpartum & Pelv Floor Rehabil, 777 Xitai Rd, Xian 710100, Shaanxi, Peoples R China.
EM xuhaiyang9992025@163.com
RI Feng, Mengmeng/HJA-5475-2022
CR Abdulaziz KS, 2021, J MUSCULOSKEL NEURON, V21, P121
   Armour M, 2021, J ALTERN COMPLEM MED, V27, P841, DOI 10.1089/acm.2021.0004
   Bittelbrunn CC, 2023, ARCH GYNECOL OBSTET, V307, P663, DOI 10.1007/s00404-022-06514-3
   Chang H, 2023, BIOMED PHARMACOTHER, V157, DOI 10.1016/j.biopha.2022.113795
   Grinberg K, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17093005
   He SH, 2022, JAMA-J AM MED ASSOC, V328, P208, DOI 10.1001/jama.2022.7489
   Lamvu G, 2021, JAMA-J AM MED ASSOC, V325, P2381, DOI 10.1001/jama.2021.2631
   Li Bo, 2023, Zhongguo Zhen Jiu, V43, P654, DOI 10.13703/j.0255-2930.20221113-k0006
   Li DH, 2018, Chinese Manipulation & Rehabilitation Medicine
   Liang Zhuo, 2021, Zhongguo Zhen Jiu, V41, P395, DOI 10.13703/j.0255-2930.20200329-k0003
   Liao C, 2024, Chin J Integr Tradit West Med Dig, V32, P711
   Liao CX, 2023, PAIN RES MANAG, V2023, DOI 10.1155/2023/3315090
   Lin KYH, 2023, HEALTHCARE-BASEL, V11, DOI 10.3390/healthcare11060830
   Liu L, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000025281
   Liu LQ, 2019, J TRADIT CHIN MED, V39, P440
   Liu Ying-Hua, 2021, Zhongguo Zhen Jiu, V41, P31, DOI 10.13703/j.0255-2930.20191218-k0002
   Parsons BA, 2022, BJU INT, V129, P572, DOI 10.1111/bju.15609
   Peng T, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000023916
   Qin ZS, 2018, J UROLOGY, V200, P815, DOI 10.1016/j.juro.2018.05.001
   Ravel J, 2021, AM J OBSTET GYNECOL, V224, P251, DOI 10.1016/j.ajog.2020.10.019
   Shroff S, 2023, MED CLIN N AM, V107, P299, DOI 10.1016/j.mcna.2022.10.009
   Song SY, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11102868
   Su D, 2022, PHYTOMEDICINE, V94, DOI 10.1016/j.phymed.2021.153833
   Wang YY, 2024, J ETHNOPHARMACOL, V319, DOI 10.1016/j.jep.2023.117373
   Yi LC, 2024, PLOS ONE, V19, DOI 10.1371/journal.pone.0292166
   Zhang Jie-Yi, 2021, Zhongguo Zhen Jiu, V41, P757, DOI [10.13703/j.0255-2930.20200713-0002, 10.13703/j.0255-2930.20200713-0002]
   Zhang LJ, 2017, J ETHNOPHARMACOL, V208, P57, DOI 10.1016/j.jep.2017.06.034
   Zheng J, 2022, J HEALTHC ENG, V2022, DOI 10.1155/2022/8770510
   Zhu GH, 2025, GINEKOL POL, V96, P304, DOI [10.5603/gp.a2021.0066, 10.5603/GP.a2021.0066]
NR 29
TC 1
Z9 1
U1 5
U2 5
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2025
VL 17
IS 7
BP 5241
EP 5256
DI 10.62347/YVFO2330
PG 16
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 5RB2M
UT WOS:001542299900031
PM 40821053
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Liu, LM
   Yin, P
   Dong, YY
   Fan, Q
   Huai, YS
   Zhang, SJ
   Lv, SY
   Wang, XY
   Chen, YL
AF Liu, Lumin
   Yin, Ping
   Dong, Yiyue
   Fan, Qian
   Huai, Yisheng
   Zhang, Shijie
   Lv, Shunyi
   Wang, Xueyang
   Chen, Yuelai
TI Neurological mechanism and efficacy of acupuncture for breast
   cancer-related insomnia: a study protocol for randomized clinical trial
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE breast cancer; insomnia; acupuncture; fMRI; randomized controlled trial;
   protocol
ID SLEEP; DEPRESSION; ANXIETY; WOMEN
AB Background: Breast cancer survivors (BCSs) are at a higher risk of developing insomnia. The negative effects of cancer-related insomnia (CRI) include depression, anxiety, fatigue, aggressive pain, impaired immune functioning, decreased quality of life, and even increased cancer mortality. Although preliminary progress has been made in the treatment of CRI with acupuncture, the evidence is insufficient and the neurological mechanism underlying the effect of acupuncture is still unclear.Methods: The study employs a single-blinded, randomized, controlled trial design. A total of 80 participants will be randomly allocated in a 1:1 ratio to either the treatment group (n = 40) or the control group (n = 40). The former will receive acupuncture treatment, while the latter will receive sham acupuncture treatment. Both groups will receive 12 sessions over a 4-week period, three times per week (every other day), and each session will last for 30 min. Follow-up assessments will be conducted in week 8. The primary outcome will be the treatment response rate. Secondary outcomes include the change in Insomnia Severity Index (ISI), the treatment remission rate, actigraphy sleep assessment, Generalized Anxiety Disorder Scale (GAD-7), Patient Health Questionnaire-9 (PHQ-9), Quality of Life Core Scale (QLQ-C30), the weekly usage of remedial drugs, and functional magnetic resonance imaging (fMRI) analysis. Data for the outcomes will be collected at week 0 (the baseline), week 1 (the intervention period), week 4 (the post-treatment period), and week 8 (the follow-up period).Discussion: The objective of this study is to assess the efficacy of acupuncture for patients with CRI in comparison with sham acupuncture. Additionally, the research aims to explore the neuropathological mechanisms of CRI and provide the first evidence on the characteristics of acupuncture treatment using fMRI. We expect that the results of this study will provide valuable scientific evidence of acupuncture treatment for CRI.
C1 [Liu, Lumin; Yin, Ping; Dong, Yiyue; Fan, Qian; Huai, Yisheng; Zhang, Shijie; Lv, Shunyi; Wang, Xueyang; Chen, Yuelai] Shanghai Univ Tradit Chinese Med, LongHua Hosp, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Chen, YL (corresponding author), Shanghai Univ Tradit Chinese Med, LongHua Hosp, Shanghai, Peoples R China.
EM chenyuelai@163.com
FU Clinical Incubation Program of the National Medical Center of LongHua
   Hospital SHUTCM [GY202201]; Shanghai Shenkang Hospital Development
   Center demonstration research ward construction project
   [SHDC2022CRW006]; Shanghai Famous Old Chinese Medicine Experts Academic
   Experience Research Studio Construction Project [SHGZS-202232]; Shanghai
   Municipal Health Commission Health Industry Clinical Research Special
   Top Project [202340110]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was supported
   by the Clinical Incubation Program of the National Medical Center of
   LongHua Hospital SHUTCM (GY202201). Additionally, it was funded by the
   Shanghai Shenkang Hospital Development Center demonstration research
   ward construction project (SHDC2022CRW006), the Shanghai Famous Old
   Chinese Medicine Experts Academic Experience Research Studio
   Construction Project (SHGZS-202232), and The Shanghai Municipal Health
   Commission Health Industry Clinical Research Special Top Project
   (202340110). These funding sources played no part in the study design
   and will not be involved in data execution, analyzes, or interpretation.
CR Aggeli P, 2021, ASIA-PAC J ONCOL NUR, V8, P147, DOI 10.4103/apjon.apjon_65_20
   [Anonymous], 1980, Diagnostic and Statistical Manual of Mental Disorders, V3rd, DOI DOI 10.1176/APPI.BOOKS.9780890425596
   Bean HR, 2021, BEHAV SLEEP MED, V19, P814, DOI 10.1080/15402002.2020.1869005
   Feng Y, 2011, J TRADIT CHIN MED, V31, P199, DOI 10.1016/S0254-6272(11)60042-3
   Frisk J, 2012, SUPPORT CARE CANCER, V20, P715, DOI 10.1007/s00520-011-1134-8
   Gao L, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/465760
   Hajj A, 2021, BMC CANCER, V21, DOI 10.1186/s12885-021-08615-9
   Husson O, 2020, ONCOLOGIST, V25, pE722, DOI 10.1634/theoncologist.2019-0348
   Kripke DF, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-000850
   Kwak A, 2020, BREAST CANCER RES TR, V181, P269, DOI 10.1007/s10549-020-05635-0
   Li J, 2017, J MED IMAG HEALTH IN, V7, P1594, DOI 10.1166/jmihi.2017.2171
   Liu ZS, 2017, JAMA-J AM MED ASSOC, V317, P2493, DOI 10.1001/jama.2017.7220
   Madsen MT, 2015, SLEEP MED REV, V20, P73, DOI 10.1016/j.smrv.2014.07.002
   Morin CM, 2020, JAMA PSYCHIAT, V77, P1107, DOI 10.1001/jamapsychiatry.2020.1767
   Morin CM, 2011, SLEEP, V34, P601, DOI 10.1093/sleep/34.5.601
   Otte JL, 2011, CLIN NURSE SPEC, V25, P228, DOI 10.1097/NUR.0b013e318229950b
   Patel JS, 2019, DEPRESS ANXIETY, V36, P813, DOI 10.1002/da.22940
   Reynolds-Cowie P, 2021, BRIT J HEALTH PSYCH, V26, P33, DOI 10.1111/bjhp.12446
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Toussaint A, 2020, J AFFECT DISORDERS, V265, P395, DOI 10.1016/j.jad.2020.01.032
   Wang YK, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-02969-6
   Zhang JL, 2023, BREAST CANCER RES, V25, DOI 10.1186/s13058-023-01645-0
   Zhang JL, 2022, PHYTOMEDICINE, V102, DOI 10.1016/j.phymed.2022.154160
   Zhang JL, 2021, INTEGR CANCER THER, V20, DOI 10.1177/15347354211019103
   Zollman FS, 2012, J HEAD TRAUMA REHAB, V27, P135, DOI 10.1097/HTR.0b013e3182051397
NR 25
TC 4
Z9 4
U1 2
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD DEC 22
PY 2023
VL 14
AR 1278564
DI 10.3389/fneur.2023.1278564
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EB7B2
UT WOS:001136503100001
PM 38187141
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Benameur, E
   Olsen, A
   Rosthoj, S
   Tjonneland, A
   Bidstrup, PE
   Kyro, C
AF Benameur, Elias
   Olsen, Anja
   Rosthoj, Susanne
   Tjonneland, Anne
   Bidstrup, Pernille E.
   Kyro, Cecilie
TI Use of complementary and alternative medicine in Denmark among women
   with and without breast cancer: a cross-sectional study
SO SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article; Early Access
DE Complementary medicine; alternative medicine; cross-sectional study;
   breast cancer; health determinants; quality of life
ID HEALTH-RELATED QUALITY; OF-LIFE; CHEMOTHERAPY; DIAGNOSIS; THERAPY;
   ANXIETY; IMPACT; PAIN
AB Aims: The study aim was to describe the use of complementary and alternative medicine (CAM) among women with breast cancer and without breast cancer in Denmark. Furthermore, the aim was to investigate whether use was related to lifestyle factors, socioeconomic factors, comorbidities, and health-related quality of life (HRQoL).Methods: A cross-sectional design was applied, and data from 1452 women aged 63-82 years collected in 2010-2011 from the Danish Diet, Cancer, and Health cohort was used. Some 717 of the women had breast cancer and 735 were without breast cancer. Multivariable logistic regression was applied with CAM use as the outcome variable and lifestyle factors, socioeconomic factors, comorbidities, and HRQoL as explanatory variables. Adjustments were made for potential confounders.Results: CAM was used by 34.3% (95% CI [30.1, 37.7]) of the women without breast cancer and 38.6% (95% CI [35.1, 42.2]) of the women with breast cancer. The most frequently used CAMs were massage, acupuncture/acupressure, relaxation techniques, reflexology, medicinal tea, herbs and plant extracts, and most CAM users used a single modality. CAM users were more likely to be younger, divorced, and less likely to smoke. Breast cancer status, body mass index, alcohol use, and comorbidity status were not significantly associated with CAM use. CAM users had lower means across all HRQoL dimensions compared to non-users.Conclusions: CAM use is common among Danish women, with no significant difference found when comparing women with and without breast cancer. CAM users seemingly had lower HRQoL, and were more likely to be younger, divorced, and less likely to smoke.
C1 [Benameur, Elias; Olsen, Anja; Rosthoj, Susanne; Tjonneland, Anne; Bidstrup, Pernille E.; Kyro, Cecilie] Danish Canc Inst, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
   [Olsen, Anja] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.
   [Tjonneland, Anne] Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Copenhagen, Denmark.
C3 Aarhus University; University of Copenhagen
RP Kyro, C (corresponding author), Danish Canc Inst, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
EM Ceciliek@cancer.dk
RI Tjonneland, Anne/AGU-0320-2022; Kyrø, Cecilie/ACG-9913-2022
OI Kyrø, Cecilie/0000-0002-9083-8960
FU National Budget of Denmark 2018 (Finansloven 2018); Danish Cancer
   Institute
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This study was
   funded through the National Budget of Denmark 2018 (Finansloven 2018),
   which secured funds for research in complementary and alternative
   medicine. This study received additional funding from the Danish Cancer
   Institute.
CR [Anonymous], 2021, Complementary, alternative, or integrative health: What's in a name?
   Arvidsson G, 2024, NORDCAN: cancer incidence, mortality, prevalence and survival in the nordic countries
   Ballatori E, 2007, SUPPORT CARE CANCER, V15, P179, DOI 10.1007/s00520-006-0109-7
   Belloni S, 2023, CLIN THER, V45, pE54, DOI 10.1016/j.clinthera.2022.12.001
   Bishop FL, 2010, EVID-BASED COMPL ALT, V7, P11, DOI 10.1093/ecam/nen023
   Boström B, 2003, J CLIN NURS, V12, P726, DOI 10.1046/j.1365-2702.2003.00777.x
   Cheung DST., 2023, Worldviews Evid Based Nurs, V20
   Commar A., 2018, WHO global report on trends in prevalence of tobacco smoking 2000-2025
   Demark-Wahnefried W, 2005, J CLIN ONCOL, V23, P5814, DOI 10.1200/JCO.2005.01.230
   Deng C, 2022, CLIN BREAST CANCER, V22, P115, DOI 10.1016/j.clbc.2021.05.006
   Fortner BV, 2002, J PAIN SYMPTOM MANAG, V24, P471, DOI 10.1016/S0885-3924(02)00500-6
   Fosså SD, 2002, J PSYCHOSOM RES, V52, P79, DOI 10.1016/S0022-3999(01)00308-7
   Fox P, 2013, EUR J ONCOL NURS, V17, P490, DOI 10.1016/j.ejon.2012.10.008
   Gjerstorff ML, 2011, SCAND J PUBLIC HEALT, V39, P42, DOI 10.1177/1403494810393562
   Goldrosen MH, 2004, NAT REV IMMUNOL, V4, P912, DOI 10.1038/nri1486
   Hanssen B, 2005, SCAND J PRIM HEALTH, V23, P57, DOI 10.1080/02813430510018419
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   John GM, 2016, J CANCER SURVIV, V10, P850, DOI 10.1007/s11764-016-0530-y
   Johnson SB, 2018, JNCI-J NATL CANCER I, V110, DOI 10.1093/jnci/djx145
   Jung AY, 2019, AM J CLIN NUTR, V109, P69, DOI 10.1093/ajcn/nqy223
   Karlsen RV, 2016, ACTA ONCOL, V55, P720, DOI 10.3109/0284186X.2015.1127415
   Keene MR, 2019, COMPLEMENT THER CLIN, V35, P33, DOI 10.1016/j.ctcp.2019.01.004
   Kemppainen LM, 2018, SCAND J PUBLIC HEALT, V46, P448, DOI 10.1177/1403494817733869
   Kraeftens Bekaempelse [Danish Cancer Society], 2023, The needs and experiences of cancer patients with the healthcare system in follow-up and aftercare, Danish Cancer Society's Barometer Survey, 2023-part2
   Kraeftens Bekaempelses [Danish Cancer Society], 2019, Barometer Survey
   Kraeftens Bekaempelses [Danish Cancer Society], 2017, Barometer Survey
   Kremser T, 2008, BREAST, V17, P387, DOI 10.1016/j.breast.2007.12.006
   Kuo YH., 2018, J Altern Complement Med, V24
   Lee SH, 2015, INTEGR CANCER THER, V14, P297, DOI 10.1177/1534735415572885
   Lovelace DL, 2019, J MIDWIFERY WOM HEAL, V64, P713, DOI 10.1111/jmwh.13012
   Luo QL, 2017, INTEGR CANCER THER, V16, P104, DOI 10.1177/1534735416643384
   Micke O, 2009, EUR J INTEGR MED, V1, P19, DOI 10.1016/j.eujim.2009.02.001
   Molassiotis A, 2005, ANN ONCOL, V16, P655, DOI 10.1093/annonc/mdi110
   Moller SR, 2024, BMC COMPLEMENT MED, V24, DOI 10.1186/s12906-023-04327-8
   Mora DC, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03537-w
   Nissen N, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-388
   Ong CK, 2002, AM J PUBLIC HEALTH, V92, P1653, DOI 10.2105/AJPH.92.10.1653
   Pedersen C G., 2009, Eur J Cancer, V45
   Salamonsen A, 2012, QUAL HEALTH RES, V22, P1497, DOI 10.1177/1049732312457077
   Shan SN, 2023, SUPPORT CARE CANCER, V31, DOI 10.1007/s00520-023-07926-w
   Shmueli A., 2007, Evid Based Complement Alternat Med, V4
   Shneerson C, 2013, COMPLEMENT THER MED, V21, P417, DOI 10.1016/j.ctim.2013.05.003
   Stöcker A, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0285718
   Sundhedsdatastyrelsen [Danish Health Data Authority], Selected chronic diseases and severe mental disorders
   Tjonneland A, 2007, SCAND J PUBLIC HEALT, V35, P432, DOI 10.1080/14034940601047986
   Ware J.E., 2007, USERS MANUAL SF 36V2, V2nd
   Wolf C., 2022, J Cancer Res Clin Oncol, V148
NR 47
TC 0
Z9 0
U1 1
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1403-4948
EI 1651-1905
J9 SCAND J PUBLIC HEALT
JI Scand. J. Public Health
PD 2025 AUG 20
PY 2025
DI 10.1177/14034948251363843
EA AUG 2025
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 6IP7E
UT WOS:001554242200001
PM 40836388
DA 2026-01-16
ER

PT J
AU Fiorini, FR
   Santoro, R
   Cristofaro, G
   Buongiorno, A
   Mannelli, G
   Picconi, M
   Gallo, O
AF Fiorini, F. R.
   Santoro, R.
   Cristofaro, G.
   Buongiorno, A.
   Mannelli, G.
   Picconi, M.
   Gallo, O.
TI Potential use of acupuncture in the treatment of first bite syndrome
SO AMERICAN JOURNAL OF OTOLARYNGOLOGY
LA English
DT Article
ID PARAPHARYNGEAL SPACE; BOTULINUM TOXIN; COMPLICATION; SURGERY
AB Objectives: First bite syndrome (FBS) is an early postoperative pain syndrome characterized by the sudden onset of pain in the parotid region at the first bite of each meal. The etiology is not certain, hence a standardized therapy does not exist.
   Methods: A 50-year old woman referred to us complaining of a swelling in the right parotid region. Fine-needle aspiration biopsy (FNAB) was diagnostic for pleomorphus adenoma of the deep lobe of the parotid gland. A 50-year old man presented with a mass in the right side of the neck, FNAB was diagnostic for parapharyngeal space neurinoma. The first patient was submitted to total parotidectomy with facial nerve preservation, the second to extracapsular dissection of the tumor. A week after surgery both patients developed FBS. A qualitative/quantitative description of pain was obtained by means of a self-coded questionnaire. The score ranges from 8 to 44, corresponding to the lowest and the highest discomfort possible, respectively. Acupuncture was used to treat these 2 patients. The treatment protocol comprised 6 sessions, one per week, lasting 30 minutes each.
   Results: Our questionnaire was administered before and after treatment and the score dropped from 33 to 25 in the female, from 30 to 15 in the male patient.
   Conclusion: PBS is a complication of upper cervical surgery with a high morbidity rate. We describe the first two cases of FBS that were successfully treated with acupuncture in our ENT department We believe that this procedure may represent a valid therapeutic alternative in the future. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Fiorini, F. R.; Santoro, R.; Cristofaro, G.; Buongiorno, A.; Mannelli, G.; Gallo, O.] Univ Florence, Deparment Surg & Translat Med, Otorhinolaryngol Clin 1, I-50121 Florence, Italy.
   [Picconi, M.] Sinergie Private Practice & Panakeia, Sch Naturopathy, Florence, Italy.
C3 University of Florence
RP Fiorini, FR (corresponding author), Via Largo Brambilla 3, I-50134 Florence, Italy.
EM francescaromanafiorini@gmail.com
OI SANTORO, ROBERTO/0000-0002-4762-772X; Mannelli,
   Giuditta/0000-0001-7079-3964; Gallo, Oreste/0000-0003-3426-7179
CR Abdeldaoui A, 2013, EUR ANN OTORHINOLARY, V130, P123, DOI 10.1016/j.anorl.2012.08.001
   Albasri H, 2011, BRIT J ORAL MAX SURG, V49, P154, DOI 10.1016/j.bjoms.2009.10.035
   Ali MJ, 2008, OTOLARYNG HEAD NECK, V139, P742, DOI 10.1016/j.otohns.2008.08.015
   Amin N, 2014, J LARYNGOL OTOL, V128, P166, DOI 10.1017/S002221511300354X
   Chiu AG, 2002, HEAD NECK-J SCI SPEC, V24, P996, DOI 10.1002/hed.10162
   Deganello A, 2011, J LARYNGOL OTOL, V125, P428, DOI 10.1017/S002221511000294X
   Diercks GR, 2011, LARYNGOSCOPE, V121, P760, DOI 10.1002/lary.21282
   Kawashima Y, 2008, AURIS NASUS LARYNX, V35, P109, DOI 10.1016/j.anl.2007.06.005
   Laccourreye O, 2013, EUR ANN OTORHINOLARY, V130, P269, DOI 10.1016/j.anorl.2012.11.003
   Lee BJ, 2009, HEAD NECK-J SCI SPEC, V31, P989, DOI 10.1002/hed.21054
   Lieberman SM, 2011, HEAD NECK-J SCI SPEC, V33, P1539, DOI 10.1002/hed.21412
   Linkov G, 2012, LARYNGOSCOPE, V122, P1773, DOI 10.1002/lary.23372
   Martlew RA, 2009, ANAESTHESIA, V64, P97, DOI 10.1111/j.1365-2044.2008.05804.x
   Netterville JL, 1998, ARCH OTOLARYNGOL, V124, P1133, DOI 10.1001/archotol.124.10.1133
   Pfister DG, 2010, J CLIN ONCOL, V28, P2565, DOI 10.1200/JCO.2009.26.9860
NR 15
TC 7
Z9 11
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0196-0709
EI 1532-818X
J9 AM J OTOLARYNG
JI Am. J. Otolaryngol.
PD MAY-JUN
PY 2015
VL 36
IS 3
BP 484
EP 487
DI 10.1016/j.amjoto.2015.01.023
PG 4
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA CI2QU
UT WOS:000354592900036
PM 25783766
DA 2026-01-16
ER

PT J
AU Tao, XS
   Lee, MCS
   Donnelly, CR
   Ji, RR
AF Tao, Xueshu
   Lee, Michael S.
   Donnelly, Christopher R.
   Ji, Ru-Rong
TI Neuromodulation, Specialized Proresolving Mediators, and Resolution of
   Pain
SO NEUROTHERAPEUTICS
LA English
DT Review
DE Auricular stimulation; chemotherapy; dorsal root ganglion; fish oil;
   resolvin; vagus nerve stimulation
ID SPINAL-CORD STIMULATION; VAGUS NERVE-STIMULATION; PRO-RESOLVING
   MEDIATORS; PRIMARY SENSORY NEURONS; N-6 FATTY-ACIDS; INFLAMMATORY PAIN;
   NEUROPATHIC PAIN; CENTRAL SENSITIZATION; ELECTRICAL-STIMULATION;
   MOLECULAR-MECHANISMS
AB The current crises in opioid abuse and chronic pain call for the development of nonopioid and nonpharmacological therapeutics for pain relief. Neuromodulation-based approaches, such as spinal cord stimulation, dorsal root ganglion simulation, and nerve stimulation including vagus nerve stimulation, have shown efficacy in achieving pain control in preclinical and clinical studies. However, the mechanisms by which neuromodulation alleviates pain are not fully understood. Accumulating evidence suggests that neuromodulation regulates inflammation and neuroinflammation-a localized inflammation in peripheral nerves, dorsal root ganglia/trigeminal ganglia, and spinal cord/brain-through neuro-immune interactions. Specialized proresolving mediators (SPMs) such as resolvins, protectins, maresins, and lipoxins are lipid molecules produced during the resolution phase of inflammation and exhibit multiple beneficial effects in resolving inflammation in various animal models. Recent studies suggest that SPMs inhibit inflammatory pain, postoperative pain, neuropathic pain, and cancer pain in rodent models via immune, glial, and neuronal modulations. It is noteworthy that sham surgery is sufficient to elevate resolvin levels and may serve as a model of resolution. Interestingly, it has been shown that the vagus nerve produces SPMs and vagus nerve stimulation (VNS) induces SPM productionin vitro. In this review, we discuss how neuromodulation such as VNS controls pain via immunomodulation and neuro-immune interactions and highlight possible involvement of SPMs. In particular, we demonstrate that VNS via auricular electroacupuncture effectively attenuates chemotherapy-induced neuropathic pain. Furthermore, auricular stimulation is able to increase resolvin levels in mice. Thus, we propose that neuromodulation may control pain and inflammation/neuroinflammatioin via SPMs. Finally, we discuss key questions that remain unanswered in our understanding of how neuromodulation-based therapies provide short-term and long-term pain relief.
C1 [Tao, Xueshu; Lee, Michael S.; Donnelly, Christopher R.; Ji, Ru-Rong] Duke Univ, Med Ctr, Dept Anesthesiol, Ctr Translat Pain Med, Durham, NC 27710 USA.
   [Ji, Ru-Rong] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA.
   [Ji, Ru-Rong] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA.
C3 Duke University; Duke University; Duke University
RP Ji, RR (corresponding author), Duke Univ, Med Ctr, Dept Anesthesiol, Ctr Translat Pain Med, Durham, NC 27710 USA.; Ji, RR (corresponding author), Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA.; Ji, RR (corresponding author), Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA.
EM ru-rong.ji@duke.edu
RI ; Ji, Ru-Rong/L-7070-2017
OI Donnelly, Christopher/0000-0003-2487-8881; Ji,
   Ru-Rong/0000-0002-9355-3688
FU Duke University; Bonica Fellowship from the International Association
   for the Study of Pain (IASP)
FX The work was supported by Duke University Research Funds. Christopher
   Donnelly was supported by Bonica Fellowship from the International
   Association for the Study of Pain (IASP).
CR Allen BL., 2020, Pain
   Arita M, 2005, J EXP MED, V201, P713, DOI 10.1084/jem.20042031
   Arita M, 2006, J BIOL CHEM, V281, P22847, DOI 10.1074/jbc.M603766200
   Bang S, 2010, BRIT J PHARMACOL, V161, P707, DOI 10.1111/j.1476-5381.2010.00909.x
   Bang SS, 2018, J CLIN INVEST, V128, P3568, DOI 10.1172/JCI99888
   Bannenberg G, 2010, BBA-MOL CELL BIOL L, V1801, P1260, DOI 10.1016/j.bbalip.2010.08.002
   Baral P, 2019, NAT REV IMMUNOL, V19, P433, DOI 10.1038/s41577-019-0147-2
   Barbanti P, 2015, J HEADACHE PAIN, V16, DOI 10.1186/s10194-015-0542-4
   Basbaum AI, 2009, CELL, V139, P267, DOI 10.1016/j.cell.2009.09.028
   Binshtok AM, 2008, J NEUROSCI, V28, P14062, DOI 10.1523/JNEUROSCI.3795-08.2008
   Borovikova LV, 2000, NATURE, V405, P458, DOI 10.1038/35013070
   Braz J, 2014, NEURON, V82, P522, DOI 10.1016/j.neuron.2014.01.018
   Buckley CD, 2014, IMMUNITY, V40, P315, DOI 10.1016/j.immuni.2014.02.009
   Busch V, 2013, BRAIN STIMUL, V6, P202, DOI 10.1016/j.brs.2012.04.006
   Cavaletti G, 2010, NAT REV NEUROL, V6, P657, DOI 10.1038/nrneurol.2010.160
   Chen G, 2018, NEURON, V100, P1292, DOI 10.1016/j.neuron.2018.11.009
   Chen O, 2020, CURR OPIN NEUROBIOL, V62, P17, DOI 10.1016/j.conb.2019.11.006
   Chiang N, 2019, J CLIN INVEST, V129, P5294, DOI 10.1172/JCI129448
   Chiang N, 2015, J EXP MED, V212, P1203, DOI 10.1084/jem.20150225
   Chiang N, 2012, NATURE, V484, P524, DOI 10.1038/nature11042
   Chiu IM, 2012, NAT NEUROSCI, V15, P1063, DOI 10.1038/nn.3144
   Clark AK, 2010, J NEUROSCI, V30, P573, DOI 10.1523/JNEUROSCI.3295-09.2010
   Coull JAM, 2005, NATURE, V438, P1017, DOI 10.1038/nature04223
   Coull JAM, 2003, NATURE, V424, P938, DOI 10.1038/nature01868
   da Silva MD, 2015, MOL NEUROBIOL, V51, P19, DOI 10.1007/s12035-014-8790-x
   Dai WJ, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/8413576
   DIXON WJ, 1980, ANNU REV PHARMACOL, V20, P441, DOI 10.1146/annurev.pa.20.040180.002301
   Duan B, 2018, NEUROSCI BULL, V34, P186, DOI 10.1007/s12264-017-0136-z
   Duffield JS, 2006, J IMMUNOL, V177, P5902, DOI 10.4049/jimmunol.177.9.5902
   Ellis A, 2013, BRIT J ANAESTH, V111, P26, DOI 10.1093/bja/aet128
   Fang JF, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1690-7
   Fattori V, 2019, BRIT J PHARMACOL, V176, P1728, DOI 10.1111/bph.14647
   Flatters SJL, 2008, PAIN, V135, P119, DOI 10.1016/j.pain.2007.05.013
   Flatters SJL, 2004, PAIN, V109, P150, DOI 10.1016/j.pain.2004.01.029
   Fullerton JN, 2016, NAT REV DRUG DISCOV, V15, P551, DOI 10.1038/nrd.2016.39
   Gao J, 2018, J PAIN RES, V11, P1511, DOI 10.2147/JPR.S160779
   Gao YJ, 2010, PAIN, V148, P309, DOI 10.1016/j.pain.2009.11.017
   Gilroy DW, 1999, NAT MED, V5, P698, DOI 10.1038/9550
   Goadsby PJ, 2014, CEPHALALGIA, V34, P986, DOI 10.1177/0333102414524494
   Goadsby PJ, 2018, CEPHALALGIA, V38, P959, DOI 10.1177/0333102417744362
   Gold MS, 2010, NAT MED, V16, P1248, DOI 10.1038/nm.2235
   Gold MS, 1998, J NEUROSCI, V18, P10345
   Goldberg RJ, 2007, PAIN, V129, P210, DOI 10.1016/j.pain.2007.01.020
   Guan Y, 2010, ANESTHESIOLOGY, V113, P1392, DOI 10.1097/ALN.0b013e3181fcd95c
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   HOKFELT T, 1994, TRENDS NEUROSCI, V17, P22, DOI 10.1016/0166-2236(94)90031-0
   Huang LA, 2011, PAIN, V152, P557, DOI 10.1016/j.pain.2010.11.021
   Huang Q, 2019, NEUROSCI BULL, V35, P527, DOI 10.1007/s12264-018-0320-9
   Hucho T, 2007, NEURON, V55, P365, DOI 10.1016/j.neuron.2007.07.008
   Inoue K, 2018, NAT REV NEUROSCI, V19, P138, DOI 10.1038/nrn.2018.2
   Ji R.R, 2011, TRENDS NEUROSCI
   Ji R.R, 2018, ANESTHESIOLOGY
   Ji RR, 1998, P NATL ACAD SCI USA, V95, P15635, DOI 10.1073/pnas.95.26.15635
   Ji RR, 2003, TRENDS NEUROSCI, V26, P696, DOI 10.1016/j.tins.2003.09.017
   Ji RR, 2002, NEURON, V36, P57, DOI 10.1016/S0896-6273(02)00908-X
   Ji RR, 2013, PAIN
   Ji RR, 2014, NAT REV DRUG DISCOV, V13, P533, DOI 10.1038/nrd4334
   Jin XC, 2006, J NEUROSCI, V26, P246, DOI 10.1523/JNEUROSCI.3858-05.2006
   Jonas WB, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-009655
   Julius D, 2001, NATURE, V413, P203, DOI 10.1038/35093019
   Kawasaki Y, 2008, J NEUROSCI, V28, P5189, DOI 10.1523/JNEUROSCI.3338-07.2008
   Krishnamoorthy S, 2010, P NATL ACAD SCI USA, V107, P1660, DOI 10.1073/pnas.0907342107
   Lai NY, 2019, CELL
   Lange G, 2011, PAIN MED, V12, P1406, DOI 10.1111/j.1526-4637.2011.01203.x
   Latremoliere A, 2009, J PAIN, V10, P895, DOI 10.1016/j.jpain.2009.06.012
   Li Y, 2014, J PAIN, V15, P712, DOI 10.1016/j.jpain.2014.04.001
   Lim HD, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151882
   Lu Y, 2013, J CLIN INVEST, V123, P4050, DOI 10.1172/JCI70026
   Lukiw WJ, 2010, MOL NEUROBIOL, V42, P10, DOI 10.1007/s12035-010-8126-4
   Lukiw WJ, 2005, J CLIN INVEST, V115, P2774, DOI 10.1172/JCI25420
   Luo H, 2019, CELL REP, V29, P2384, DOI 10.1016/j.celrep.2019.10.085
   Luo X, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00745
   MAIXNER W, 1984, BRAIN RES, V298, P374, DOI 10.1016/0006-8993(84)91441-0
   Martelletti P, 2018, J HEADACHE PAIN, V19, DOI 10.1186/s10194-018-0946-z
   Martini AC, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-016-0540-8
   Matsuda M, 2019, J ANESTH, V33, P131, DOI 10.1007/s00540-018-2579-4
   MELZACK R, 1965, SCIENCE, V150, P971, DOI 10.1126/science.150.3699.971
   Miao GS, 2015, NEUROSCIENCE, V300, P10, DOI 10.1016/j.neuroscience.2015.04.060
   Milligan ED, 2003, J NEUROSCI, V23, P1026
   Mirakaj V, 2014, J EXP MED, V211, P1037, DOI 10.1084/jem.20132103
   Moore KA, 2002, J NEUROSCI, V22, P6724, DOI 10.1523/jneurosci.22-15-06724.2002
   Moreno-Duarte I, 2014, NEUROIMAGE, V85, P1003, DOI 10.1016/j.neuroimage.2013.05.097
   Napadow V, 2012, PAIN MED, V13, P777, DOI 10.1111/j.1526-4637.2012.01385.x
   Norling LV, 2016, JCI INSIGHT, V1, DOI 10.1172/jci.insight.85922
   Norling LV, 2011, J IMMUNOL, V186, P5543, DOI 10.4049/jimmunol.1003865
   Norris PC, 2016, PROSTAGLANDINS LEUKO
   Obata K, 2005, J CLIN INVEST, V115, P2393, DOI 10.1172/JCI23437
   Oehler B, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00242
   Oh DY, 2010, CELL, V142, P687, DOI 10.1016/j.cell.2010.07.041
   Palacios-Pelaez R, 2010, MOL NEUROBIOL, V41, P367, DOI 10.1007/s12035-010-8139-z
   Park CK, 2014, NEURON, V82, P47, DOI 10.1016/j.neuron.2014.02.011
   Park CK, 2011, J NEUROSCI, V31, P18433, DOI 10.1523/JNEUROSCI.4192-11.2011
   Park CK, 2011, J NEUROSCI, V31, P15072, DOI 10.1523/JNEUROSCI.2443-11.2011
   Patapoutian A, 2009, NAT REV DRUG DISCOV, V8, P55, DOI 10.1038/nrd2757
   Pawela CP, 2017, NEUROIMAGE, V147, P10, DOI 10.1016/j.neuroimage.2016.11.046
   Peirs C, 2016, SCIENCE, V354, P578, DOI 10.1126/science.aaf8933
   Ramsden CE, 2015, PAIN, V156, P587, DOI 10.1097/01.j.pain.0000460348.84965.47
   Ramsden CE, 2013, PAIN, V154, P2441, DOI 10.1016/j.pain.2013.07.028
   Ruscheweyh R, 2011, MOL PAIN, V7, DOI 10.1186/1744-8069-7-20
   Samad TA, 2001, NATURE, V410, P471, DOI 10.1038/35068566
   Sato KL, 2014, ANESTH ANALG, V118, P464, DOI 10.1213/ANE.0000000000000047
   Serhan CN, 2019, J INTERN MED, V286, P240, DOI 10.1111/joim.12871
   Serhan CN, 2018, J IMMUNOL, V201, P3161, DOI 10.4049/jimmunol.1800806
   Serhan CN, 2014, NATURE, V510, P92, DOI 10.1038/nature13479
   Serhan CN, 2012, FASEB J, V26, P1755, DOI 10.1096/fj.11-201442
   SERHAN CN, 1984, P NATL ACAD SCI-BIOL, V81, P5335, DOI 10.1073/pnas.81.17.5335
   Shamji MF, 2017, NEUROSURGERY, V80, pS108, DOI 10.1093/neuros/nyw047
   Sisignano M, 2014, NAT REV NEUROL, V10, P694, DOI 10.1038/nrneurol.2014.211
   Sisignano M, 2012, J NEUROSCI, V32, P6364, DOI 10.1523/JNEUROSCI.5793-11.2012
   Spite M, 2009, NATURE, V461, P1287, DOI 10.1038/nature08541
   Steinberg BE, 2016, ANESTHESIOLOGY, V124, P1174, DOI 10.1097/ALN.0000000000001083
   Sulciner ML, 2018, J EXP MED, V215, P115, DOI 10.1084/jem.20170681
   Svensson CI, 2007, J EXP MED, V204, P245, DOI 10.1084/jem.20061826
   Svensson CI, 2003, J NEUROCHEM, V86, P1534, DOI 10.1046/j.1471-4159.2003.01969.x
   Tassorelli C, 2018, NEUROLOGY, V91, pE364, DOI 10.1212/WNL.0000000000005857
   Torres-Rosas R, 2014, NAT MED, V20, P291, DOI 10.1038/nm.3479
   Tracey KJ, 2002, NATURE, V420, P853, DOI 10.1038/nature01321
   Usoskin D, 2015, NAT NEUROSCI, V18, P145, DOI 10.1038/nn.3881
   Volkow ND, 2017, NEW ENGL J MED, V377, P391, DOI 10.1056/NEJMsr1706626
   Wang JC, 2017, J PAIN
   Wei TP, 2009, PAIN, V144, P278, DOI 10.1016/j.pain.2009.04.020
   White FA, 2005, NAT REV DRUG DISCOV, V4, P834, DOI 10.1038/nrd1852
   Woolf CJ, 2007, NEURON, V55, P353, DOI 10.1016/j.neuron.2007.07.016
   Woolf CJ, 2011, PAIN, V152, pS2, DOI 10.1016/j.pain.2010.09.030
   Xu ZZ, 2013, ANN NEUROL, V74, P490, DOI 10.1002/ana.23928
   Xu ZZ, 2013, J NEUROIMMUNE PHARM, V8, P37, DOI 10.1007/s11481-012-9394-8
   Xu ZZ, 2011, BRIT J PHARMACOL, V164, P274, DOI 10.1111/j.1476-5381.2011.01348.x
   Xu ZZ, 2010, NAT MED, V16, P592, DOI 10.1038/nm.2123
   Yang F, 2015, NEUROMODULATION, V18, P592, DOI 10.1111/ner.12341
   Yang Q, 2014, J NEUROSCI, V34, P10765, DOI 10.1523/JNEUROSCI.5316-13.2014
   Ye Y, 2018, NEUROPHARMACOLOGY, V139, P182, DOI 10.1016/j.neuropharm.2018.07.016
   Zhang LL, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00412
   Zhang RX, 2007, ANESTH ANALG, V105, P1482, DOI 10.1213/01.ane.0000284705.34629.c5
   Zhang TC, 2015, J NEUROPHYSIOL, V114, P284, DOI 10.1152/jn.00147.2015
   Zheng Y, 2019, NEURON
   Zhuang ZY, 2006, J NEUROSCI, V26, P3551, DOI 10.1523/JNEUROSCI.5290-05.2006
NR 136
TC 44
Z9 50
U1 2
U2 37
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1933-7213
EI 1878-7479
J9 NEUROTHERAPEUTICS
JI Neurotherapeutics
PD JUL
PY 2020
VL 17
IS 3
SI SI
BP 886
EP 899
DI 10.1007/s13311-020-00892-9
EA JUL 2020
PG 14
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA OL3SN
UT WOS:000550997000001
PM 32696274
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Weisfeld, CC
   Turner, JA
   Dunleavy, K
   Ko, A
   Bowen, JI
   Roelk, B
   Eissa, R
   Benfield, E
   Robertson, K
AF Weisfeld, Carol C.
   Turner, Jill A.
   Dunleavy, Kim
   Ko, Arthur
   Bowen, Jennifer I.
   Roelk, Brandi
   Eissa, Reem
   Benfield, Erica
   Robertson, Kristen
TI Dealing with Anxious Patients: A Systematic Review of the Literature on
   Nonpharmaceutical Interventions to Reduce Anxiety in Patients Undergoing
   Medical or Dental Procedures
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review
DE patient anxiety; music; patient education; massage; distraction;
   hypnosis
ID MUSIC; DEPRESSION; SURGERY; PAIN
AB Objectives: State (situational) anxiety can create suboptimal outcomes for patients across a variety of health care specializations. While anxiolytic medications reduce anxiety, problematic side effects can compromise outcomes. These challenges have spurred searches for nonpharmaceutical approaches to alleviate patient anxiety. This systematic literature review, largely following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, aimed to determine patterns and effectiveness of interventions across medical health care specialty areas, including dentistry.
   Methods: A systematic review was conducted, using PubMed, CINAHL, and PsycINFO databases, with search terms related to anxiety, specific interventions, and medical or dental procedures. Hand searching for additional citations was performed on the bibliographies of dissertations, meta-analyses, and systematic reviews that met article inclusion criteria. The search process yielded 48,324 articles and 257 dissertations published in English between 1974 and 2018. Each abstract was evaluated for inclusion by two reviewers, yielding 718 articles that were read and evaluated for outcomes, risk of bias, pretest and post-test, controls and quality, using a Critical Appraisal Skills Programme instrument. Of these, 408 articles, describing 501 experimental trials, were accepted for inclusion in this analysis.
   Results: A total of 50,343 patients were included in these experiments, with an overall success rate of 71% for reducing patient anxiety. Results are summarized by health care specialty area: surgery, oncology, cardiology, obstetrics/gynecology, dentistry, and pain/trauma, and the following diagnostic testing and intervention areas: imaging, colonoscopy, mechanical ventilation, and other. The largest number of experiments (114) was in the surgery category. The types of interventions included music, education, relaxation, cognitive behavioral therapy (CBT), massage, distraction, hypnosis, acupuncture/acupressure, social support, aromatherapy, nature sounds, natural visual stimuli, special garment, and other. The largest numbers of experiments were done with music (143) and education (130).
   Discussion: The following interventions were most successful, reducing anxiety in over 70% of experiments: music, CBT, relaxation, massage, acupuncture/acupressure, hypnosis, and natural sounds. Confidence in results is limited by publication bias, small sample sizes, and the lack of placebo controls. Directions for future research are discussed.
C1 [Weisfeld, Carol C.; Roelk, Brandi; Eissa, Reem; Benfield, Erica] Univ Detroit Mercy, Dept Psychol, 4001 West McNichols Rd, Detroit, MI 48219 USA.
   [Turner, Jill A.; Bowen, Jennifer I.] Univ Detroit Mercy, Lib IDS, Detroit, MI 48221 USA.
   [Dunleavy, Kim] Univ Florida, Dept Phys Therapy, Gainesville, FL USA.
   [Ko, Arthur] Univ Detroit Mercy, Coll Hlth Profess, McAuley Sch Nursing, Detroit, MI 48221 USA.
   [Robertson, Kristen] Walk Line Recovery Therapy, Orthoped Phys Therapy Program, Southfield, MI USA.
C3 University of Detroit Mercy; University of Detroit Mercy; State
   University System of Florida; University of Florida; University of
   Detroit Mercy
RP Weisfeld, CC (corresponding author), Univ Detroit Mercy, Dept Psychol, 4001 West McNichols Rd, Detroit, MI 48219 USA.
EM weisfecc@udmercy.edu
RI Dunleavy, Kim/Y-8485-2019
OI Weisfeld, Carol/0000-0002-8040-6582; Turner, Jill/0000-0003-0813-8488
CR Bailey Laila, 2010, AORN J, V92, P445, DOI 10.1016/j.aorn.2010.04.017
   Bell SK, 2019, J CONTIN EDUC HEALTH, V39, P201, DOI 10.1097/CEH.0000000000000259
   Benedetti F, 2011, PATIENT EDUC COUNS, V84, P413, DOI 10.1016/j.pec.2011.04.034
   Bringman H, 2009, ACTA ANAESTH SCAND, V53, P759, DOI 10.1111/j.1399-6576.2009.01969.x
   CHAPMAN CR, 1977, J PSYCHOSOM RES, V21, P7, DOI 10.1016/0022-3999(77)90020-4
   Chaturvedi SK, 1996, PSYCHO-ONCOL, V5, P343, DOI 10.1002/(SICI)1099-1611(199612)5:4<343::AID-PON232>3.3.CO;2-E
   Chernyak Y, 2020, J CLIN PSYCHOL MED S, V27, P305, DOI 10.1007/s10880-019-09691-7
   Critical Appraisal Skills Programme, 2015, CASP RAND CONTR TRIA
   Daitch C., 2014, EUR J PERS CENT HEAL, V2, P303
   Dallam SJ., 2010, THESIS U KANSAS LAWR
   ENGEL GL, 1981, J MED PHILOS, V6, P101, DOI 10.1093/jmp/6.2.101
   Eshed I, 2007, J MAGN RESON IMAGING, V26, P401, DOI 10.1002/jmri.21012
   Gallagher R, 2010, EUR J CARDIOVASC NUR, V9, P38, DOI 10.1016/j.ejcnurse.2009.09.001
   Grey SJ, 2000, MAGN RESON IMAGING, V18, P351, DOI 10.1016/S0730-725X(00)00112-0
   Hedgpeth, 2012, THESIS W U HLTH SCI
   Heikkilä J, 1998, J ADV NURS, V28, P1225, DOI 10.1046/j.1365-2648.1998.00852.x
   Lushene, 1983, MANUAL STATE TRAIT A
   Moher D, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b2535
   Shahid M, 2019, INT DENT J, V69, P369, DOI 10.1111/idj.12483
   SHAW DW, 1974, J COUNS PSYCHOL, V21, P415, DOI 10.1037/h0037102
   Song MZ, 2018, J ADV NURS, V74, P1016, DOI 10.1111/jan.13509
   Tolunay T, 2018, INJURY, V49, P593, DOI 10.1016/j.injury.2018.02.008
   Tsay SL, 2005, J ADV NURS, V52, P142, DOI 10.1111/j.1365-2648.2005.03576.x
   Tugwell JR, 2018, RADIOGRAPHY, V24, P122, DOI 10.1016/j.radi.2017.10.001
   Weiland TJ, 2011, MED J AUSTRALIA, V195, P694, DOI 10.5694/mja10.10662
   Williams JB, 2013, AM J CARDIOL, V111, P137, DOI 10.1016/j.amjcard.2012.08.060
   Yinger OS, 2015, J MUSIC THER, V52, P1, DOI 10.1093/jmt/thv004
NR 27
TC 14
Z9 20
U1 2
U2 38
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD SEP 1
PY 2021
VL 27
IS 9
BP 717
EP 726
DI 10.1089/acm.2020.0504
EA JUN 2021
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA UP8ZQ
UT WOS:000657060400001
PM 34076531
DA 2026-01-16
ER

PT J
AU Sasaki, Y
   Cheon, C
   Motoo, Y
   Jang, S
   Park, S
   Ko, SG
   Jang, BH
   Hwang, DS
AF Sasaki, Yui
   Cheon, Chunhoo
   Motoo, Yoshiharu
   Jang, Soobin
   Park, Sunju
   Ko, Seong-Gyu
   Jang, Bo-Hyoung
   Hwang, Deok-Sang
TI Complementary and Alternative Medicine for Breast Cancer Patients: An
   Overview of Systematic Reviews
SO YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
LA Japanese
DT Review
DE complementary and alternative medicine; breast cancer; overview;
   systematic review
ID QUALITY-OF-LIFE; TAI-CHI; YOGA INTERVENTIONS; ADJUNCTIVE THERAPY; STRESS
   REDUCTION; HERBAL MEDICINE; HOT FLASHES; ACUPUNCTURE; SURVIVORS; WOMEN
AB The application of systematic review (SR) has been increased rapidly in the field of cancer treatment. Complementary and alternative medicine (CAM) for cancer is no exception. The aim of this review is to evaluate and summarize systematic reviews on the CAM use in breast cancer patients. Search sources were Centre for Reviews and Dissemination (CRD), Cochrane Database of Systematic Reviews (CDSR), and PubMed. In addition, we assessed the quality of SR with the Assessing the Methodological Quality of Systematic Reviews (AMSTAR). This review did not consider control groups and outcomes. Thirty-four SRs met a set of criteria. According to interventions, there were twenty SRs which included yoga, acupuncture, and herbal medicines. Meta-analysis of 19 out of 34 reviews showed the followings: (1) acupuncture had a beneficial effect on the frequency of hot flushes, (2) yoga had a beneficial effect on depression and health-related QOL, (3) mindfulness-based stress reduction (MBSR) had a beneficial effect on anxiety and depression, (4) combination of herbal medicine and chemotherapy synergistically improved clinical outcomes, (5) acupuncture did not show significant effect on the severity of hot flushes and cancer-related pain, (6) yoga was unable to be confirmed as having an effect on cancer-related pain and physical well-being. Given the results of AMSTAR, 9 out of 34 reviews were of high quality and 3 reviews were deemed to be of low quality. In conclusion, since most SRs were at moderate or high quality levels, CAM could be helpful for treating specific symptoms related to breast cancer.
C1 [Sasaki, Yui] Kyung Hee Univ, Grad Sch, Dept Appl Korean Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Cheon, Chunhoo; Ko, Seong-Gyu; Jang, Bo-Hyoung] Kyung Hee Univ, Coll Korean Med, Dept Prevent Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Motoo, Yoshiharu] Kanazawa Med Univ, Dept Med Oncol, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan.
   [Jang, Soobin] Korea Inst Oriental Med, Clin Med Div, 1672 Yuseong Daero, Daejeon 34054, South Korea.
   [Park, Sunju] Daejeon Univ, Coll Korean Med, Dept Prevent Med, 62 Daehak Ro, Daejeon 34520, South Korea.
   [Hwang, Deok-Sang] Kyung Hee Univ, Coll Korean Med, Dept Korean Gynecol, 26 Kyungheedae Ro, Seoul 02447, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kanazawa Medical University;
   Korea Institute of Oriental Medicine (KIOM); Daejeon University; Kyung
   Hee University
RP Hwang, DS (corresponding author), Kyung Hee Univ, Coll Korean Med, Dept Korean Gynecol, 26 Kyungheedae Ro, Seoul 02447, South Korea.
EM soulhus@gmail.com
RI Jang, Bo-Hyoung/ABF-2923-2020; Jang, Soobin/ODN-1434-2025; Motoo,
   Yoshiharu/E-8277-2011; Cheon, Chunhoo/ABH-9070-2020
OI Jang, Bo-Hyoung/0000-0002-2141-3483; Sasaki, Yui/0000-0002-4057-9294;
   Jang, Soobin/0000-0003-0943-9290; Cheon, Chunhoo/0000-0002-7078-0079
CR AMSTAR, WHAT IS AMSTAR
   Buffart LM, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-559
   Chao LF, 2009, BREAST CANCER RES TR, V118, P255, DOI 10.1007/s10549-009-0533-8
   Chen YP, 2016, J CANCER RES THER, V12, P535, DOI 10.4103/0973-1482.172716
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Chiu HY, 2016, CANCER NURS, V39, P228, DOI 10.1097/NCC.0000000000000278
   CONSORT, NONPH TREATM INT
   Cramer H, 2012, CURR ONCOL, V19, pE343, DOI 10.3747/co.19.1016
   Cramer H, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010802.pub2
   Cramer H, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-412
   De Groef A, 2015, ARCH PHYS MED REHAB, V96, P1140, DOI 10.1016/j.apmr.2015.01.006
   Foundation for Promotion of Cancer research, CANC STAT JAP 2017
   Fritz H, 2014, INTEGR CANCER THER, V13, P12, DOI 10.1177/1534735413477191
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Harder H, 2012, SUPPORT CARE CANCER, V20, P3055, DOI 10.1007/s00520-012-1611-8
   Hyodo I, 2005, J CLIN ONCOL, V23, P2645, DOI 10.1200/JCO.2005.04.126
   Japanese Breast Cancer Society, 2018, JAP BREAST CANC SOC
   Japanese Society for Palliative Medicine, 2016, CLIN EV COMPL ALT TH
   Johannsen M, 2013, BREAST CANCER RES TR, V138, P675, DOI 10.1007/s10549-013-2503-4
   Johns C, 2016, BREAST CANCER RES TR, V156, P415, DOI 10.1007/s10549-016-3765-4
   Kassab S, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004845.pub2
   Kim JI, 2010, INTEGR CANCER THER, V9, P326, DOI 10.1177/1534735410387423
   Kim W, 2015, COMPLEMENT THER MED, V23, P626, DOI 10.1016/j.ctim.2015.03.011
   Kojima M., ARTICLES 4 UTILIZATI
   Lee MS, 2007, SUPPORT CARE CANCER, V15, P597, DOI 10.1007/s00520-007-0221-3
   Lee MS, 2010, BREAST CANCER RES TR, V120, P309, DOI 10.1007/s10549-010-0741-2
   Lee MS, 2009, BREAST CANCER RES TR, V115, P497, DOI 10.1007/s10549-008-0230-z
   Lin KY, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1155/2011/659876
   Ministry of Health Labour and Welfare, STRUCT ABSTR EJIM
   Ministry of Health Labour and Welfare, INF SIT EV BAS JAP I
   National Center for Complementary and Integrative Health, IMP EV
   Ohno S, 2016, Journal for the Integrated Study of Dietary Habits, V27, P3, DOI 10.2740/jisdh.27.3
   Pan YQ, 2014, INT J CLIN ONCOL, V19, P829, DOI 10.1007/s10147-013-0635-5
   Pan YQ, 2017, ASIA-PAC J CLIN ONCO, V13, pE79, DOI 10.1111/ajco.12329
   Sadja J, 2013, EXPLORE-NY, V9, P232, DOI 10.1016/j.explore.2013.04.005
   Santos S. D., 2010, MED ACUPUNCT, V22, P81
   Seely Dugald, 2005, Integr Cancer Ther, V4, P144, DOI 10.1177/1534735405276420
   Sharma M, 2016, J CANCER RES CLIN, V142, P2523, DOI 10.1007/s00432-016-2269-2
   Shin ES, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009873.pub3
   Silva V, 2015, SAO PAULO MED J, V133, P206, DOI 10.1590/1516-3180.2013.8150015
   Silva V, 2012, SAO PAULO MED J, V130, P398, DOI 10.1590/S1516-31802012000600007
   Stuiver MM, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009765.pub2
   Suzuki K, 2017, Palliative Care Research, V12, P731, DOI [10.2512/jspm.12.731, DOI 10.2512/JSPM.12.731, 10.2512/jspm.12.731]
   The Japan Society for Oriental Medicine, EV REP KAMP TREATM E
   The Joint Commission, NEW JOINT COMM ADV N
   The Joint Commission, JAN 1 2018 JOINT COM
   Wang W, 2015, CELL BIOCHEM BIOPHYS, V71, P1299, DOI 10.1007/s12013-014-0348-z
   Yan JH, 2014, ASIAN PAC J CANCER P, V15, P3715, DOI 10.7314/APJCP.2014.15.8.3715
   Zainal NZ, 2013, PSYCHO-ONCOLOGY, V22, P1457, DOI 10.1002/pon.3171
   Zhang J, 2012, J ALTERN COMPLEM MED, V18, P994, DOI 10.1089/acm.2011.0514
   Zhang M, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004921.pub2
   Zhu LB, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/9469276
NR 52
TC 12
Z9 14
U1 2
U2 24
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0031-6903
J9 YAKUGAKU ZASSHI
JI Yakugaku Zasshi-J. Pharm. Soc. Jpn.
PD JUL
PY 2019
VL 139
IS 7
BP 1027
EP 1046
DI 10.1248/yakushi.18-00215
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IG1PD
UT WOS:000473562600011
PM 31257250
OA gold
DA 2026-01-16
ER

PT J
AU Zou, J
   Dong, XY
   Wang, K
   Shi, J
   Sun, N
AF Zou, Jing
   Dong, Xueyang
   Wang, Ke
   Shi, Jing
   Sun, Ning
TI Electroacupuncture Inhibits Autophagy of Neuron Cells in Postherpetic
   Neuralgia by Increasing the Expression of miR-223-3p
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
AB Postherpetic neuralgia (PHN) is a complication of herpes zoster viral infection. Its main manifestations are continuous or intermittent burning-like and electroshock-like pain in the affected nerves. Electroacupuncture (EA) is widely used in clinical treatment and exerts effects in alleviating neuropathic pain. In this study, we investigated the effect and underlying mechanism of EA on PHN. Sprague-Dawley rats were treated with resiniferatoxin (RTX) to establish a PHN model and subjected to EA and/or miR-223-3p overexpression (OV) or interference. Mechanical withdrawal latency was measured as an indication of pain sensitivity. Hematoxylin-eosin staining and transmission electron microscopy were performed to observe neuron cell morphology and autophagic vacuoles, respectively. ELISA was performed to detect reactive oxygen species (ROS) production and the levels of tumor necrosis factor- (TNF-) alpha, inducible nitric oxide synthase (iNOS), interleukin- (IL-) 6, and IL-10. Changes in autophagy and apoptosis-related miRNAs were detected by immunofluorescence and qRT-PCR, respectively. In RTX-treated rats, OV and EA reduced pain sensitivity, decreased the number of eosinophils, and increased that of nerve cells. ROS generation and the levels of TNF-alpha and iNOS were significantly reduced, while those of IL-6 and IL-10 were increased. OV and EA induced fewer autophagic vacuoles than those in the model group. The expression of autophagy-related protein microtubule-associated protein 1 light chain 3-II, ATG9, and Rab1 was decreased by OV and EA, whereas that of P62 was increased. qRT-PCR revealed that miR-223-3p expression in the model group decreased but was increased by EA. EA inhibits neuron cell autophagy in PHN by increasing miR-223-3p expression.
C1 [Zou, Jing; Shi, Jing; Sun, Ning] Huazhong Univ Sci & Technol, Dept Neurobiol, Sch Basic Med, Tongji Med Coll, Wuhan, Peoples R China.
   [Zou, Jing] Huazhong Univ Sci & Technol, Dept Acupuncture & Moxibust, Wuhan Hosp Integrated Chinese & Western Med, Tongji Med Coll, Wuhan, Peoples R China.
   [Dong, Xueyang] Wuhan Hosp Integrated Chinese & Western Med, Wuhan, Peoples R China.
   [Wang, Ke] Hubei Univ Tradit Chinese Med, Acupuncture Coll, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Hubei University of Chinese Medicine
RP Sun, N (corresponding author), Huazhong Univ Sci & Technol, Dept Neurobiol, Sch Basic Med, Tongji Med Coll, Wuhan, Peoples R China.
EM 2709104613@qq.com; 291130015@qq.com; 1047948620@qq.com;
   sj@mails.tjmu.edu.cn; nsun@hust.edu.cn
RI Sun, Ning/JNF-0604-2023
OI Sun, Ning/0000-0001-9711-5354
FU National Natural Science Foundation of China [31471015, 31771126,
   81271452]; Fundamental Research Funds for the Central Universities, HUST
   [2016YXMS193]
FX This work was supported financially by the National Natural Science
   Foundation of China (Nos. 31471015, 31771126, and 81271452) and the
   Fundamental Research Funds for the Central Universities, HUST
   (2016YXMS193).
CR Abraham TS, 2011, J CHEM NEUROANAT, V41, P129, DOI 10.1016/j.jchemneu.2011.01.001
   Armstrong DA, 2017, CLIN EPIGENETICS, V9, DOI 10.1186/s13148-017-0355-1
   Berman BM, 2004, ANN INTERN MED, V141, P901, DOI 10.7326/0003-4819-141-12-200412210-00006
   Chen C, 2014, J MOL ENDOCRINOL, V52, P311, DOI 10.1530/JME-14-0013
   Chen WJ, 2017, NEUROCHEM RES, V42, P634, DOI 10.1007/s11064-016-2119-2
   Chua CEL, 2011, CELL MOL LIFE SCI, V68, P3349, DOI 10.1007/s00018-011-0748-9
   Ding QP, 2018, PATHOL RES PRACT, V214, P1330, DOI 10.1016/j.prp.2018.05.012
   Ding SS, 2014, QJM-INT J MED, V107, P341, DOI 10.1093/qjmed/hct196
   DIXON WJ, 1991, NEUROSCI BIOBEHAV R, V15, P47, DOI 10.1016/S0149-7634(05)80090-9
   Dong HC, 2019, INFLAMMATION, V42, P1265, DOI 10.1007/s10753-019-00986-3
   Dong N, 2017, MOL MED REP, V15, P731, DOI 10.3892/mmr.2016.6044
   Eacker SM, 2009, NAT REV NEUROSCI, V10, P837, DOI 10.1038/nrn2726
   Giles KM, 2013, BIOCHEM BIOPH RES CO, V430, P706, DOI 10.1016/j.bbrc.2012.11.086
   Gozuacik D, 2017, FRONT ONCOL, V7, DOI 10.3389/fonc.2017.00065
   Huang J, 2011, AUTOPHAGY, V7, P17, DOI 10.4161/auto.7.1.13840
   Iorio MV, 2012, EMBO MOL MED, V4, P143, DOI 10.1002/emmm.201100209
   Ji LJ, 2018, J CELL BIOCHEM, V119, P1017, DOI 10.1002/jcb.26269
   Jiang HL, 2016, J TRADIT CHIN MED, V36, P85
   Jiang QY, 2016, ACUPUNCT MED, V34, P223, DOI 10.1136/acupmed-2015-010951
   Kloosterman WP, 2006, DEV CELL, V11, P441, DOI 10.1016/j.devcel.2006.09.009
   Lan HY, 2015, BIOMED RES INT-UK, V2015, DOI 10.1155/2015/125094
   李卉丽, 2003, [生理科学进展, Progress in Physiological Sciences], V34, P45
   Li JQ., 2009, J Clin Anesth, V25
   Li Qiu-Yue, 2017, Zhongguo Zhong Yao Za Zhi, V42, P3709, DOI 10.19540/j.cnki.cjcmm.20170907.004
   Li Z, 2017, FRONT CELL INFECT MI, V7, DOI 10.3389/fcimb.2017.00155
   Liu K., 2018, J CELL BIOCHEM, V6
   Mao JR, 2002, J NEUROSCI, V22, P7650
   Zoppino FCM, 2010, TRAFFIC, V11, P1246, DOI 10.1111/j.1600-0854.2010.01086.x
   Sakai A, 2013, BRAIN, V136, P2738, DOI 10.1093/brain/awt191
   Sekiguchi M, 2009, EUR SPINE J, V18, P1978, DOI 10.1007/s00586-009-1064-z
   Sorge RE, 2012, NAT MED, V18, P595, DOI 10.1038/nm.2710
   Su SX, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00126
   Sun Y.Z., 2015, CHINESE ACUPUNCTURE, V1, P4
   Sun YH, 2017, BMC CARDIOVASC DISOR, V17, DOI 10.1186/s12872-017-0549-7
   Szabo G, 2013, NAT REV GASTRO HEPAT, V10, P542, DOI 10.1038/nrgastro.2013.87
   Tsuda M, 2009, P NATL ACAD SCI USA, V106, P8032, DOI 10.1073/pnas.0810420106
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Wang JY, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/204367
   Wang JY, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/249013
   Wu CH, 2016, MOL NEUROBIOL, V53, P5640, DOI 10.1007/s12035-015-9482-x
   Wu CH, 2013, MOL PAIN, V9, DOI 10.1186/1744-8069-9-18
   Xie XJ, 2017, CELL PHYSIOL BIOCHEM, V41, P181, DOI 10.1159/000455987
   Xu CQ, 2007, J CELL SCI, V120, P3045, DOI 10.1242/jcs.010728
   Yan XT, 2017, INT IMMUNOPHARMACOL, V46, P156, DOI 10.1016/j.intimp.2017.01.027
   Yao CL, 2017, ONCOTARGET, V8, P57670, DOI 10.18632/oncotarget.16917
   Zhou CQ, 2017, CELL RES, V27, P184, DOI 10.1038/cr.2016.146
   Zou J, 2019, NEUROTOX RES, V36, P387, DOI 10.1007/s12640-019-00052-8
NR 47
TC 24
Z9 32
U1 3
U2 30
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD MAR 8
PY 2021
VL 2021
AR 6637693
DI 10.1155/2021/6637693
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA RN3UN
UT WOS:000640278500001
PM 33860046
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Enblom, A
   Lagerstedt, K
AF Enblom, Anna
   Lagerstedt, Kristina
TI Understanding rationales for acupuncture treated individuals' beliefs in
   acupuncture effects, to be able to maximize therapeutic results: A
   qualitative analysis
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Acupuncture therapy; Complementary and alternative medicine;
   Expectations; Nausea; Relaxation; Qualitative methods
ID ALTERNATIVE MEDICINE; CHRONIC PAIN; PLACEBO; COMPLEMENTARY;
   EXPECTATIONS; TOUCH
AB Objective: To investigate how individuals expressed rationales for their beliefs regarding efficacy of acupuncture.
   Methods: Qualitative data from participants of two different randomized sham-controlled trials, of relaxing (non cancer volunteers of the general population) or antiemetic (patients with cancer undergoing radiotherapy) effects of acupuncture was analyzed. Participants (n = 441) received genuine (n = 120 and n = 100) or sham (n = 121 and n = 100) (telescopic blunt sham-needle) relaxing or antiemetic acupuncture. The participants (n = 428; 97% response rate) expressed their belief regarding the efficacy of acupuncture, and n = 264 delivered qualitative rationales for their belief, analyzed using qualitative content analysis.
   Results: Of the 428 participants, 35 (8%) believed entirely that the acupuncture was effective, 209 (49%) believed much, 136 (32%) believed moderately, 39 (9%) believed a little, and 9 (2%) did not believe that the acupuncture was effective. Five categories and seven subcategories represented the meaning units of the central message of the rationales for the treatment belief. Participants with positive beliefs (believed entirely/much, n = 244) presented rationales related to: "Experienced positive effects", "Knowledge regarding effect-mechanisms of acupuncture", and "General trustworthiness of acupuncture". Participants with more negative beliefs (believed a little or not, n = 48) presented rationales related to: "Lack of feasibility of the acupuncture", "Varying effects", and "The effect is individual, not available for everybody".
   Conclusion: In order to strengthen acupuncture treated patients' beliefs in the efficacy of acupuncture during clinical practice or research, acupuncture therapists may consider emphasizing these aspects in the therapeutic situation.
C1 [Enblom, Anna; Lagerstedt, Kristina] Linkoping Univ, Div Physiotherapy, Dept Med & Hlth Sci, Linkoping, Sweden.
   [Lagerstedt, Kristina] Avonova, Vaxjo, Sweden.
   [Lagerstedt, Kristina] Linkoping Univ, Dept Med & Hlth Sci, Div Physiotherapy, Linkoping, Sweden.
C3 Linkoping University; Linkoping University
RP Enblom, A (corresponding author), Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden.
EM anna.enblom@liu.se
FU Swedish Cancer Society; Vardal Institute; Region of Ostergotland;
   University of Linkoping; Cancer Rehabilitation Foundation; Osher Centrum
   for Integrative Medicine, Karolinska Institute
FX We thank all the participants of this study, Boel Lindberg, Ingrid
   Tiligren, and Annelie Rosen for coordinating, all physiotherapists for
   treatments, and Sussanne Borjeson, Mats Hammar, Gunnar Steineck, Mats
   Lekander, Predrag Petrovic, Karin Jensen, Lisbeth Sachs, and Martin
   Ingvar for their valuable contributions within the original randomized
   controlled trials. This study was supported by The Swedish Cancer
   Society, The Vardal Institute, The Region of Ostergotland, The
   University of Linkoping, the Cancer Rehabilitation Foundation, and the
   Osher Centrum for Integrative Medicine, Karolinska Institute. The
   funders have no role in the study design, in the collection, analysis
   and interpretation of data; in the writing of the manuscript; or in the
   decision to submit the manuscript for publication.
CR [Anonymous], COCHRANE DATABASE SY
   [Anonymous], 2016, EVID-BASED COMPL ALT, DOI DOI 10.1155/2016/1720239
   [Anonymous], 2010, COCHRANE DATABASE SY
   Benedetti F, 2012, J ACUPUNCT MERIDIAN, V5, P97, DOI 10.1016/j.jams.2012.03.001
   Bishop FL, 2016, COMPLEMENT THER MED, V27, P74, DOI 10.1016/j.ctim.2016.06.005
   Chae Y, 2017, ACUPUNCT MED, V35, P148, DOI 10.1136/acupmed-2016-011178
   Colagiuri B, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/857804
   Cormier S, 2016, PAIN, V157, P329, DOI 10.1097/j.pain.0000000000000379
   de Lorent L, 2016, J ACUPUNCT MERIDIAN, V9, P191
   Di Blasi Z, 2001, LANCET, V357, P757, DOI 10.1016/S0140-6736(00)04169-6
   Elo S, 2008, J ADV NURS, V62, P107, DOI 10.1111/j.1365-2648.2007.04569.x
   Enblom A, 2012, ANN ONCOL, V23, P1353, DOI 10.1093/annonc/mdr402
   Enblom A, 2017, ACUPUNCT MED, V35, P251, DOI 10.1136/acupmed-2015-011007
   Enblom A, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/5806351
   Enblom A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014766
   Enck P, 2013, NAT REV DRUG DISCOV, V12, P191, DOI 10.1038/nrd3923
   Finniss DG, 2010, LANCET, V375, P686, DOI 10.1016/S0140-6736(09)61706-2
   Geers AL, 2010, J PAIN, V11, P1165, DOI 10.1016/j.jpain.2010.02.014
   Grelotti DJ, 2011, BRIT MED J, V343, DOI 10.1136/bmj.d4345
   Hsu C, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-276
   Huang Y, 2012, NEURAL REGEN RES, V7, P2362, DOI 10.3969/j.issn.1673-5374.2012.30.006
   Kaptchuk TJ, 2009, CULT MED PSYCHIAT, V33, P382, DOI 10.1007/s11013-009-9141-7
   Kelley JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094207
   Keysers C, 2007, TRENDS COGN SCI, V11, P194, DOI 10.1016/j.tics.2007.02.002
   Kligler B, 2015, J ALTERN COMPLEM MED, V21, P713, DOI 10.1089/acm.2014.0376
   Krippendorff KlausH., 2013, Content Analysis, V3rd
   Lai XS, 2009, NEUROSCI LETT, V452, P194, DOI 10.1016/j.neulet.2009.01.052
   MacPherson Hugh, 2005, Acupunct Med, V23, P112
   McGlone F, 2014, NEURON, V82, P737, DOI 10.1016/j.neuron.2014.05.001
   Meissner K, 2013, JAMA INTERN MED, V173, P1941, DOI 10.1001/jamainternmed.2013.10391
   Melzack R., 2005, World Institute of Pain, V5, P85, DOI [DOI 10.1111/J.1533-2500.2005.05203.X, 10.1111/j.1533-2500.2005.05203.x]
   Mondloch MV, 2001, CAN MED ASSOC J, V165, P174
   Odsberg A, 2001, COMPLEMENT THER MED, V9, P17, DOI 10.1054/ctim.2000.0418
   Oscarsson L, 2017, RANDOMIZED CONTROLLE
   Pariente J, 2005, NEUROIMAGE, V25, P1161, DOI 10.1016/j.neuroimage.2005.01.016
   Park J., 1999, ACUPUNCT MED, V17, P110
   Peerdeman KJ, 2016, PAIN, V157, P1179, DOI 10.1097/j.pain.0000000000000540
   Roscoe JA, 2010, J PAIN SYMPTOM MANAG, V40, P379, DOI 10.1016/j.jpainsymman.2009.12.024
   Rossi E, 2015, SUPPORT CARE CANCER, V23, P1795, DOI 10.1007/s00520-014-2517-4
   Sandelowski M, 2000, RES NURS HEALTH, V23, P334, DOI 10.1002/1098-240X(200008)23:4<334::AID-NUR9>3.0.CO;2-G
   Smith K, 2016, BIOETHICS, V30, P60, DOI 10.1111/bioe.12243
   Soliday Elizabeth, 2014, Glob Adv Health Med, V3, P14, DOI 10.7453/gahmj.2013.086
   Suarez-Almazor ME, 2010, ARTHRIT CARE RES, V62, P1229, DOI 10.1002/acr.20225
   Vase L, 2002, PAIN, V99, P443, DOI 10.1016/S0304-3959(02)00205-1
   Vase L, 2009, PAIN, V145, P36, DOI 10.1016/j.pain.2009.04.008
   Zhang CS, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140825
NR 46
TC 1
Z9 2
U1 0
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD AUG
PY 2018
VL 39
BP 101
EP 108
DI 10.1016/j.ctim.2018.04.006
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA GP3TF
UT WOS:000440775400017
PM 30012380
DA 2026-01-16
ER

PT J
AU Segev, Y
   Abofol, S
   Samuels, N
   Schmidt, M
   Assaf, W
   Ben-Arye, E
AF Segev, Yakir
   Abofol, Sereen
   Samuels, Noah
   Schmidt, Meirav
   Assaf, Wisam
   Ben-Arye, Eran
TI Postoperative pain following intraoperative acupuncture: a
   randomized-controlled study
SO BMJ SUPPORTIVE & PALLIATIVE CARE
LA English
DT Article
DE Integrative Oncology; Pain; Supportive care
ID MEDICINE
AB Context and objectives This study examined the impact of an integrative oncology intervention on postoperative care, primarily postoperative pain, in patients undergoing gynaecological oncology surgery.Methods Participants were randomised to three groups: group A, preoperative touch/relaxation modalities, followed by intraoperative acupuncture; group B, preoperative touch/relaxation only and group C, standard conventional care alone. Using an enhanced recovery after surgery (ERAS) protocol, medical personnel retrospectively assessed pain on each postoperative day (POD), using a Visual Analogue Scale (VAS; 0, no pain; 10, most severe pain). Use of analgesics, bowel movements, urination and number of days until discharge were also assessed.Results A total of 102 patients participated, with similar baseline demographic and surgery-related characteristics among the three groups (group A, 45; group B, 25 and group C, 32). Group A patients undergoing laparoscopic surgery reported significantly lower pain scores on POD1 than group C (p=0.018). Group B patients undergoing open laparotomy were discharged earlier than group C (p=0.031). No significant between-group differences were found for VAS pain scales, use of analgesics or report of first postoperative bowel movement or urination.Conclusions This prospective, controlled and pragmatic ERAS-based study suggests that intraoperative acupuncture may reduce postoperative pain on POD1, in patients undergoing laparoscopic gynaecological oncology surgery. The findings differ from a previous study which found no effect of acupuncture on pain-related haemodynamic parameters during laparoscopy. Further research using objective nociception parameters is needed to explore the effect of intraoperative acupuncture on postoperative pain.Trial registration number ClinicalTrials.gov (NCT03560388)
C1 [Segev, Yakir; Schmidt, Meirav; Assaf, Wisam] carmel Med Ctr, Gynecol Dept, Div Gynecol Oncol obster, H_efa, Israel.
   [Abofol, Sereen] Carmel Hosp, Obstet & Gynecol Dept, Haifa, Israel.
   [Samuels, Noah] Shaare Zedek Med Ctr, Ctr Integrat Complementary Med, Jerusalem, Israel.
   [Ben-Arye, Eran] LIN Med Ctr, H_aifa, Israel.
   [Ben-Arye, Eran] Clalit Hlth Serv, Tel Aviv, Israel.
C3 Clalit Health Services; Carmel Medical Center; Clalit Health Services;
   Carmel Medical Center; Hebrew University of Jerusalem; Shaare Zedek
   Medical Center; Clalit Health Services
RP Segev, Y (corresponding author), carmel Med Ctr, Gynecol Dept, Div Gynecol Oncol obster, H_efa, Israel.
EM segevyakir@yahoo.com; Sereen.abofol@gmail.com; integrative@szmc.org.il;
   smeiravm@gmail.com; wissam_assaf_90@hotmail.com; ERANBE@clalit.org.il
FU The Israel Cancer Association; Israel Cancer Association
FX We would like to thank the Israel Cancer Association for their financial
   support through a research grant for the present research project. We
   would also like to thank Professor Ofer Lavie, Dr Orit Gressel, Ms Galit
   Galil, Dr Michael Gretz, Dr Irena Hirsh, Dr Inbal Marom and Dr Ludmila
   Ostrovsky for their contribution in the development and implementation
   of the present research. We are also thankful to Ms Nili Stein for the
   statistical analysis.
CR Baldawi M, 2022, J INTEGR COMPLEMENT, V28, P683, DOI 10.1089/jicm.2021.0429
   Ben-Arye E, 2023, J CANCER RES CLIN, V149, P8177, DOI 10.1007/s00432-023-04758-3
   Ben-Arye E, 2023, CURR ONCOL REP, V25, P559, DOI 10.1007/s11912-023-01359-8
   Ben-Arye E, 2023, CANCER-AM CANCER SOC, V129, P908, DOI 10.1002/cncr.34542
   Ben-Arye E, 2022, CANCER-AM CANCER SOC, V128, P3641, DOI 10.1002/cncr.34422
   Bondi A, 2021, J HOLIST NURS, V39, P58, DOI 10.1177/0898010120936437
   Carlson LE, 2023, J CLIN ONCOL, V41, P4562, DOI 10.1200/JCO.23.00857
   Felix MMD, 2018, REV LAT-AM ENFERM, V26, DOI 10.1590/1518-8345.2850.3101
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Ozhanli Y, 2022, J PERIANESTH NURS, V37, P238, DOI 10.1016/j.jopan.2021.08.008
   Rithirangsriroj K, 2015, GYNECOL ONCOL, V136, P82, DOI 10.1016/j.ygyno.2014.10.025
   Segev Y, 2021, SUPPORT CARE CANCER, V29, P4055, DOI 10.1007/s00520-020-05961-5
   Shalom-Sharabi I, 2017, J CANCER RES CLIN, V143, P2535, DOI 10.1007/s00432-017-2509-0
   Stark PA, 2013, ANESTHESIOLOGY, V118, P1332, DOI 10.1097/ALN.0b013e318289b84b
   Wiles MD, 2017, ANAESTHESIA, V72, P335, DOI 10.1111/anae.13785
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
   Xue FS, 2023, CANCER-AM CANCER SOC, V129, P1939, DOI 10.1002/cncr.34805
NR 18
TC 0
Z9 0
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2045-435X
EI 2045-4368
J9 BMJ SUPPORT PALLIAT
JI BMJ Support. Palliat. Care
PD SEP
PY 2025
VL 15
IS 5
BP 642
EP 647
DI 10.1136/spcare-2025-005485
EA JUN 2025
PG 6
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 6YX0Q
UT WOS:001511423100001
PM 40537176
DA 2026-01-16
ER

PT J
AU Bao, T
   Cai, L
   Giles, JT
   Gould, J
   Tarpinian, K
   Betts, K
   Medeiros, M
   Jeter, S
   Tait, N
   Chumsri, S
   Armstrong, DK
   Tan, M
   Folkerd, E
   Dowsett, M
   Singh, H
   Tkaczuk, K
   Stearns, V
AF Bao, Ting
   Cai, Ling
   Giles, Jon T.
   Gould, Jeff
   Tarpinian, Karineh
   Betts, Kelly
   Medeiros, Michelle
   Jeter, Stacie
   Tait, Nancy
   Chumsri, Saranya
   Armstrong, Deborah K.
   Tan, Ming
   Folkerd, Elizabeth
   Dowsett, Mitch
   Singh, Harvinder
   Tkaczuk, Kate
   Stearns, Vered
TI A dual-center randomized controlled double blind trial assessing the
   effect of acupuncture in reducing musculoskeletal symptoms in breast
   cancer patients taking aromatase inhibitors
SO BREAST CANCER RESEARCH AND TREATMENT
LA English
DT Article
DE Breast cancer; Acupuncture; Aromatase inhibitor; Musculoskeletal
   symptoms
ID JOINT SYMPTOMS; WOMEN; SERUM; ASSOCIATIONS; DISABILITY; ANTIBODY;
   THERAPY; IL-17
AB Up to 50 % of women receiving aromatase inhibitor (AI) complain of AI-associated musculoskeletal symptoms (AIMSS) and 15 % discontinue treatment. We conducted a randomized, sham-controlled trial to evaluate whether acupuncture improves AIMSS and to explore potential mechanisms. Postmenopausal women with early stage breast cancer, experiencing AIMSS were randomized to eight weekly real or sham acupuncture sessions. We evaluated changes in the Health Assessment Questionnaire Disability Index (HAQ-DI) and pain visual analog scale (VAS) following the intervention compared to baseline. Serum estradiol, beta-endorphin, and proinflammatory cytokine concentrations were measured pre and post-intervention. We enrolled 51 women of whom 47 were evaluable, including 23 randomized to real and 24 to sham acupuncture. Baseline characteristics were balanced between groups with the exception of a higher HAQ-DI score in the real acupuncture group (p = 0.047). We did not observe a statistically significant difference in reduction of HAQ-DI (p = 0.30) or VAS (p = 0.31) between the two groups. Following eight weekly treatments, we observed a statistically significant reduction of IL-17 (p a parts per thousand currency sign 0.009) in both groups. No significant modulation was seen in estradiol, beta-endorphin, or other proinflammatory cytokine concentrations in either group. We did not observe a significant difference in AIMSS changes between real and sham acupuncture. As sham acupuncture used in this study may not be equivalent to placebo, further studies with a non-acupuncture arm may be required to establish whether acupuncture is beneficial for the treatment of AIMSS.
C1 [Bao, Ting; Cai, Ling; Betts, Kelly; Medeiros, Michelle; Tait, Nancy; Chumsri, Saranya; Tan, Ming; Singh, Harvinder; Tkaczuk, Kate] Univ Maryland, Greenebaum Canc Ctr, Baltimore, MD 20201 USA.
   [Giles, Jon T.] Columbia Univ, Div Rheumatol, New York, NY 10032 USA.
   [Gould, Jeff; Tarpinian, Karineh; Jeter, Stacie; Armstrong, Deborah K.; Stearns, Vered] Sidney Kimmel Comprehens Canc Ctr, Johns Hopkins Sch Med, Baltimore, MD 21231 USA.
   [Folkerd, Elizabeth; Dowsett, Mitch] Royal Marsden Hosp, Acad Dept Biochem, London SW3 6JJ, England.
C3 University System of Maryland; University of Maryland Baltimore;
   Columbia University; Johns Hopkins University; Johns Hopkins Medicine;
   Royal Marsden NHS Foundation Trust
RP Bao, T (corresponding author), Univ Maryland, Greenebaum Canc Ctr, Baltimore, MD 20201 USA.
EM tbao@umm.edu
RI Tamburini, jerome/LBH-1975-2024; Dowsett, MItch/AGC-4236-2022
OI Stearns, Vered/0000-0003-4018-4708; Giles, Jon/0000-0002-8792-0402; Bao,
   Ting/0000-0003-4437-2597
FU ASCO Foundation Young Investigator's Award; Susan Komen Postdoctoral
   Fellowship Award; Breast Cancer Research Foundation; Maryland Affiliate
   of Susan G. Komen for the Cure Craft grant; Novartis; GSK; Merck;
   AstraZeneca; Pfizer; National Institute for Health Research
   [NF-SI-0512-10122] Funding Source: researchfish
FX The authors thank Dr. Xiaobu Ye for statistical support. The authors
   thank Drs. N. Lynn Henry and Richard Harris for helpful discussions
   regarding study design. This trial was supported by ASCO Foundation
   Young Investigator's Award, Susan Komen Postdoctoral Fellowship Award,
   Breast Cancer Research Foundation, Maryland Affiliate of Susan G. Komen
   for the Cure Craft grant. TB is a Paul Calabresi scholar (K12 CA126849
   A).SC has consultant/advisory role in Novartis, and receives research
   funding from Novartis, GSK, Merck; MD has consultant/advisory role in
   GSK, and receives research funding from AstraZeneca, Novartis; VS
   receives research funding from Pfizer, Novartis.
CR [Anonymous], EVID BASED COMPLEMEN
   Arican O, 2005, MEDIAT INFLAMM, P273, DOI 10.1155/MI.2005.273
   Berk DR, 2006, J GERONTOL A-BIOL, V61, P97, DOI 10.1093/gerona/61.1.97
   Bruce Bonnie, 2003, Health Qual Life Outcomes, V1, P20, DOI 10.1186/1477-7525-1-20
   Burstein HJ, 2007, BREAST, V16, P223, DOI 10.1016/j.breast.2007.01.011
   Burstein HJ, 2010, J CLIN ONCOL, V28, P3784, DOI 10.1200/JOP.000082
   CHEN XH, 1992, EUR J PHARMACOL, V211, P203
   Cherkin DC, 2009, ARCH INTERN MED, V169, P858, DOI 10.1001/archinternmed.2009.65
   Crew KD, 2007, J CLIN ONCOL, V25, P3877, DOI 10.1200/JCO.2007.10.7573
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Cuzick J, 2008, LANCET, V371, P2156, DOI 10.1016/S0140-6736(08)60933-2
   Deng G, 2007, J CLIN ONCOL, V25, P5584, DOI 10.1200/JCO.2007.12.0774
   Harris RE, 2005, J ALTERN COMPLEM MED, V11, P663, DOI 10.1089/acm.2005.11.663
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Henry NL, 2008, ONCOLOGY-NY, V22, P1401
   Ingle JN, 2010, J CLIN ONCOL, V28, P4674, DOI 10.1200/JCO.2010.28.5064
   Khan QJ, 2012, J CLIN ONCOL S, V30
   Krishnan E, 2004, ARTHRITIS RHEUM-US, V50, P953, DOI 10.1002/art.20048
   Leonardi C, 2012, NEW ENGL J MED, V366, P1190, DOI 10.1056/NEJMoa1109997
   Liu MH, 2012, BREAST CANCER RES, V14, DOI 10.1186/bcr3137
   Maciocia G., 2005, Foundations of Chinese medicine: A comprehensive text for acupuncturists and herbalists
   Moffet HH, 2009, J ALTERN COMPLEM MED, V15, P213, DOI 10.1089/acm.2008.0356
   Papp KA, 2012, NEW ENGL J MED, V366, P1181, DOI 10.1056/NEJMoa1109017
   Partridge AH, 2003, J CLIN ONCOL, V21, P602, DOI 10.1200/JCO.2003.07.071
   Rosu A, 2012, ROM J MORPHOL EMBRYO, V53, P73
   Singh S, 2012, BREAST CANCER RES TR, V132, P625, DOI 10.1007/s10549-011-1911-6
   Vas J, 2012, PAIN, V153, P1883, DOI 10.1016/j.pain.2012.05.033
   Wolfe F, 2005, J RHEUMATOL, V32, P583
   Wu MT, 2002, NEUROIMAGE, V16, P1028, DOI 10.1006/nimg.2002.1145
NR 29
TC 74
Z9 87
U1 1
U2 37
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0167-6806
EI 1573-7217
J9 BREAST CANCER RES TR
JI Breast Cancer Res. Treat.
PD FEB
PY 2013
VL 138
IS 1
BP 167
EP 174
DI 10.1007/s10549-013-2427-z
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 099CX
UT WOS:000315598200017
PM 23393007
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Su, TF
   Zhao, YQ
   Zhang, LH
   Peng, M
   Wu, CH
   Pei, L
   Tian, B
   Zhang, J
   Shi, J
   Pan, HL
   Li, M
AF Su, T. -F.
   Zhao, Y. -Q.
   Zhang, L. -H.
   Peng, M.
   Wu, C. -H.
   Pei, L.
   Tian, B.
   Zhang, J.
   Shi, J.
   Pan, H. -L.
   Li, M.
TI Electroacupuncture reduces the expression of proinflammatory cytokines
   in inflamed skin tissues through activation of cannabinoid CB2 receptors
SO EUROPEAN JOURNAL OF PAIN
LA English
DT Article
ID NERVE GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; RAT SENSORY NEURONS;
   GENE-RELATED PEPTIDE; DORSAL-ROOT GANGLIA; INFLAMMATORY HYPERALGESIA;
   PERIPHERAL INFLAMMATION; CUTANEOUS HYPERALGESIA; T-LYMPHOCYTES;
   SPINAL-CORD
AB Endogenous cannabinoids and peripheral cannabinoid CB2 receptors (CB2Rs) are involved in the antinociceptive effect of electroacupuncture (EA) on inflammatory pain. However, it is not clear how CB2R activation contributes to the antinociceptive effect of EA. The major proinflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and IL-6, are involved in inflammatory pain. Here we determined the effects of CB2R activation and EA on the expression level of IL-1 beta, IL-6 and TNF-alpha in inflamed skin tissues. Inflammatory pain was induced by injection of complete Freund's adjuvant into the left hindpaw of rats. Thermal hyperalgesia was tested with a radiant heat stimulus, and mechanical allodynia was quantified using von Frey filaments. The mRNA and protein levels of IL-1 beta, IL-6 and TNF-alpha in inflamed skin tissues were measured using real-time polymerase chain reaction and Western blot, respectively. Local injection of the selective CB2R agonist AM1241 or EA applied to GB30 and GB34 significantly reduced thermal hyperalgesia and mechanical allodynia induced by tissue inflammation. The specific CB2R antagonist AM630 significantly attenuated the antinociceptive effect of EA. Furthermore, EA or AM1241 treatment significantly decreased the mRNA and protein levels of IL-1 beta, IL-6 and TNF-alpha in inflamed skin tissues. In addition, pretreatment with AM630 significantly reversed the inhibitory effect of EA on these cytokine levels in inflamed skin tissues. Our results suggest that EA reduces inflammatory pain and proinflammatory cytokines in inflamed skin tissues through activation of CB2Rs.
C1 [Su, T. -F.; Zhao, Y. -Q.; Zhang, L. -H.; Peng, M.; Wu, C. -H.; Pei, L.; Tian, B.; Zhang, J.; Shi, J.; Li, M.] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Neurobiol, Wuhan 430030, Peoples R China.
   [Su, T. -F.; Zhao, Y. -Q.; Zhang, L. -H.; Peng, M.; Wu, C. -H.; Pei, L.; Tian, B.; Zhang, J.; Shi, J.; Li, M.] Huazhong Univ Sci & Technol, Tongji Med Coll, Key Lab Neurol Dis Hubei Prov, Wuhan 430030, Peoples R China.
   [Pan, H. -L.] Univ Texas MD Anderson Canc, Dept Anesthesiol & Perioperat Med, Houston, TX 77030 USA.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; University of Texas System; UTMD Anderson Cancer
   Center
RP Li, M (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Neurobiol, 13 Hangkong Rd, Wuhan 430030, Peoples R China.
EM liman7322@hotmail.com
RI Su, Tangfeng/AAH-9767-2020
OI Su, Tangfeng/0000-0002-1925-5519; Pan, Hui-Lin/0000-0001-8444-3770; Li,
   Man/0000-0003-4041-0437
FU National Natural Science Foundation of China [30600832]; Scientific
   Research Foundation for the Returned Overseas Chinese Scholars of State
   Education Ministry [2008890]; Fundamental Research Funds for the Central
   Universities (HUST) [2010JC065]
FX This work was supported by a grant from the National Natural Science
   Foundation of China (#30600832), funds from the Scientific Research
   Foundation for the Returned Overseas Chinese Scholars of State Education
   Ministry (#2008890), and the Fundamental Research Funds for the Central
   Universities (HUST #2010JC065).
CR AKIRA S, 1993, ADV IMMUNOL, V54, P1, DOI 10.1016/S0065-2776(08)60532-5
   Berdyshev EV, 1997, EUR J PHARMACOL, V330, P231, DOI 10.1016/S0014-2999(97)01007-8
   Chagnon F, 2005, CIRC RES, V96, P1095, DOI 10.1161/01.RES.0000168327.22888.4d
   Chang YH, 2001, J CELL BIOCHEM, V81, P715, DOI 10.1002/jcb.1103
   Chen L, 2009, J PAIN, V10, P732, DOI 10.1016/j.jpain.2008.12.012
   CLEMENTJONES V, 1980, LANCET, V2, P946
   Cook CD, 2006, PHYSIOL BEHAV, V87, P552, DOI 10.1016/j.physbeh.2005.12.005
   Copray JCVM, 2001, J NEUROIMMUNOL, V118, P203, DOI 10.1016/S0165-5728(01)00324-1
   CUNHA FQ, 1992, BRIT J PHARMACOL, V107, P660, DOI 10.1111/j.1476-5381.1992.tb14503.x
   Dallos A, 2006, NEUROPEPTIDES, V40, P251, DOI 10.1016/j.npep.2006.06.002
   Delettieres Dreanina, 2004, Clin Dev Immunol, V11, P253, DOI 10.1080/17402520400001686
   Du Jing, 2008, Zhen Ci Yan Jiu, V33, P37
   FACCI L, 1995, P NATL ACAD SCI USA, V92, P3376, DOI 10.1073/pnas.92.8.3376
   FERREIRA SH, 1988, NATURE, V334, P698, DOI 10.1038/334698a0
   Fu X, 2007, NEUROSCIENCE, V144, P275, DOI 10.1016/j.neuroscience.2006.09.016
   FUKUOKA H, 1994, BRAIN RES, V657, P133, DOI 10.1016/0006-8993(94)90960-1
   GALIEGUE S, 1995, EUR J BIOCHEM, V232, P54, DOI 10.1111/j.1432-1033.1995.tb20780.x
   Gutierrez T, 2007, BRIT J PHARMACOL, V150, P153, DOI 10.1038/sj.bjp.0706984
   HARGREAVES K, 1988, PAIN, V32, P77, DOI 10.1016/0304-3959(88)90026-7
   Heinrich PC, 1998, BIOCHEM J, V334, P297, DOI 10.1042/bj3340297
   Hohmann AG, 2004, J PHARMACOL EXP THER, V308, P446, DOI 10.1124/jpet.103.060079
   Hohmann AG, 1999, NEUROSCIENCE, V90, P923, DOI 10.1016/S0306-4522(98)00524-7
   Ibrahim MM, 2005, P NATL ACAD SCI USA, V102, P3093, DOI 10.1073/pnas.0409888102
   Junger H, 2000, PAIN, V85, P145, DOI 10.1016/S0304-3959(99)00262-6
   KUNO K, 1994, J LEUKOCYTE BIOL, V56, P542, DOI 10.1002/jlb.56.5.542
   Kupczyk P, 2009, EXP DERMATOL, V18, P669, DOI 10.1111/j.1600-0625.2009.00923.x
   KUPPER TS, 1989, ANN NY ACAD SCI, V557, P454
   LEE JH, 1993, PAIN, V52, P11, DOI 10.1016/0304-3959(93)90109-3
   Levy ASA, 2009, W INDIAN MED J, V58, P295
   Li Jun-Jun, 2007, Zhen Ci Yan Jiu, V32, P9
   Li WW, 2009, PAIN, V144, P303, DOI 10.1016/j.pain.2009.04.033
   Liu Fei, 2006, Zhongguo Zhen Jiu, V26, P436
   Malan TP, 2001, PAIN, V93, P239, DOI 10.1016/S0304-3959(01)00321-9
   MCMAHON SB, 1995, NAT MED, V1, P774, DOI 10.1038/nm0895-774
   MUNRO S, 1993, NATURE, V365, P61, DOI 10.1038/365061a0
   Nackley AG, 2004, J NEUROPHYSIOL, V92, P3562, DOI 10.1152/jn.00886.2003
   Nicol GD, 1997, J NEUROSCI, V17, P975
   Obreja O, 2005, BRAIN, V128, P1634, DOI 10.1093/brain/awh490
   Obreja O, 2002, FASEB J, V16, P1497, DOI 10.1096/fj.02-0101com
   Oprée A, 2000, J NEUROSCI, V20, P6289, DOI 10.1523/JNEUROSCI.20-16-06289.2000
   Parada CA, 2003, EUR J NEUROSCI, V17, P1847, DOI 10.1046/j.1460-9568.2003.02626.x
   PEETS JM, 1978, NATURE, V273, P675, DOI 10.1038/273675a0
   Quartilho A, 2003, ANESTHESIOLOGY, V99, P955, DOI 10.1097/00000542-200310000-00031
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Ross RA, 1999, BRIT J PHARMACOL, V126, P665, DOI 10.1038/sj.bjp.0702351
   SAFIEHGARABEDIAN B, 1995, BRIT J PHARMACOL, V115, P1265, DOI 10.1111/j.1476-5381.1995.tb15035.x
   Sekido R, 2004, AM J CHINESE MED, V32, P269, DOI 10.1142/S0192415X04001928
   Suzuki S, 1999, J CEREBR BLOOD F MET, V19, P1256, DOI 10.1097/00004647-199911000-00010
   Tewari-Singh N, 2009, TOXICOL SCI, V108, P194, DOI 10.1093/toxsci/kfn261
   VILLIGER PM, 1991, J IMMUNOL, V146, P550
   VONFLIEDNER V, 1992, CELL IMMUNOL, V139, P198, DOI 10.1016/0008-8749(92)90112-3
   Wang LN, 2006, BRAIN RES, V1120, P46, DOI 10.1016/j.brainres.2006.08.077
   Woolf CJ, 1997, BRIT J PHARMACOL, V121, P417, DOI 10.1038/sj.bjp.0701148
   WOOLF CJ, 1994, NEUROSCIENCE, V62, P327, DOI 10.1016/0306-4522(94)90366-2
   Xu XJ, 1997, CYTOKINE, V9, P1028, DOI 10.1006/cyto.1997.0243
   Yang B, 2005, KIDNEY INT, V68, P2050, DOI 10.1111/j.1523-1755.2005.00662.x
   Yao BB, 2008, BRIT J PHARMACOL, V153, P390, DOI 10.1038/sj.bjp.0707568
   Yung KT, 2005, AM J CHINESE MED, V33, P759, DOI 10.1142/S0192415X05003302
   Zhang J, 2010, J PAIN, V11, P1250, DOI 10.1016/j.jpain.2010.02.013
   Zhang RX, 2007, ANESTH ANALG, V105, P1482, DOI 10.1213/01.ane.0000284705.34629.c5
   Zhang RX, 2004, BRAIN RES, V1020, P12, DOI 10.1016/j.brainres.2004.05.067
   ZIMMERMANN M, 1983, PAIN, V16, P109, DOI 10.1016/0304-3959(83)90201-4
NR 62
TC 72
Z9 90
U1 0
U2 33
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1090-3801
EI 1532-2149
J9 EUR J PAIN
JI Eur. J. Pain
PD MAY
PY 2012
VL 16
IS 5
BP 624
EP 635
DI 10.1002/j.1532-2149.2011.00055.x
PG 12
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA 980OC
UT WOS:000306901700002
PM 22337285
DA 2026-01-16
ER

PT J
AU Goluza, E
   Hudolin, T
   Konosic, S
   Pranjic, MN
   Sprajc, SN
   Penezic, L
   Kulis, T
AF Goluza, Eleonora
   Hudolin, Tvrtko
   Konosic, Sanja
   Pranjic, Marina Nakic
   Sprajc, Sandra Nenadic
   Penezic, Luka
   Kulis, Tomislav
TI CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME: TREATMENT OPTIONS WITH
   NEUROMODULATORY PHARMACOTHERAPY AND ACUPUNCTURE
SO ACTA CLINICA CROATICA
LA English
DT Article
DE chronic prostatitis; chronic pelvic pain syndrome; neuromodulatory
   pharmacotherapy; acupuncture
ID MANAGEMENT; MEN; PREGABALIN; SYMPTOMS
AB Chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS) is a prevalent condition with complex pathogenesis, and the most effective treatment is still unknown. The negative impact of CP/CPPS on patient quality of life (QoL) is significant and represents a challenge for many clinicians. Additionally, studies have indicated a potential association between prostatitis and prostate cancer. Many pharmacologic and nonpharmacologic therapies have been utilized in everyday clinical practice, but the majority have demonstrated limited effectiveness in reducing symptoms. Current "first- line" pharmacology treatment options include antibiotics, anti-inflammatory, alpha-blockers, and 5-alpha reductase inhibitors as monoterapy or their combination, despite the fact that systematic reviews and meta-analyses show that many treatments for CP/CPPS are largely ineffective. Thus far, no highly effective therapy has been identified, and treatment strategies have focused on symptomatic relief. Evidence indicates that CP/CPPS may involve neuropathic pain to varying degrees, and neuromodulatory pharmacotherapy and acupuncture could therefore be considered as potential treatments for cases that are refractory to standard therapies.
C1 [Goluza, Eleonora; Konosic, Sanja; Pranjic, Marina Nakic; Sprajc, Sandra Nenadic] Univ Zagreb, Univ Hosp Ctr Zagreb, Dept Anesthesiol Reanimatol & Intens Care, Kispaticeva 12, Zagreb 10000, Croatia.
   [Hudolin, Tvrtko; Penezic, Luka; Kulis, Tomislav] Univ Hosp Ctr Zagreb, Dept Urol, Zagreb, Croatia.
   [Goluza, Eleonora; Hudolin, Tvrtko; Konosic, Sanja; Kulis, Tomislav] UNIV ZAGREB, Fac Med, ZAGREB, Croatia.
C3 University of Zagreb; University of Zagreb Hospital; University of
   Zagreb; University of Zagreb Hospital; University of Zagreb
RP Goluza, E (corresponding author), Univ Zagreb, Univ Hosp Ctr Zagreb, Dept Anesthesiol Reanimatol & Intens Care, Kispaticeva 12, Zagreb 10000, Croatia.
EM egoluza@gmail.com
RI Kulis, Tomislav/AAF-5565-2020
CR Anothaisintawee T, 2011, JAMA-J AM MED ASSOC, V305, P78, DOI 10.1001/jama.2010.1913
   Balzani E, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9091239
   Bates D, 2019, PAIN MED, V20, pS2, DOI 10.1093/pm/pnz075
   Bennett MI, 2004, PALLIATIVE MED, V18, P5, DOI 10.1191/0269216304pm845ra
   Besson JM, 1999, LANCET, V353, P1610, DOI 10.1016/S0140-6736(99)01313-6
   Cabyoglu MT, 2006, INT J NEUROSCI, V116, P115, DOI 10.1080/00207450500341472
   Chao AS, 2007, PAIN, V127, P214, DOI 10.1016/j.pain.2006.08.016
   Chen R, 2003, UROLOGY, V61, P1156, DOI 10.1016/S0090-4295(03)00141-9
   Cho Seok, 2019, Urogenital Tract Infection, V14, P55, DOI [10.14777/uti.2019.14.2.55, 10.14777/uti.2019.14.2.55]
   Desireddi NV, 2008, J UROLOGY, V179, P1857, DOI 10.1016/j.juro.2008.01.028
   Finnerup NB, 2016, PAIN, V157, P1599, DOI 10.1097/j.pain.0000000000000492
   Finnerup NB, 2015, LANCET NEUROL, V14, P162, DOI 10.1016/S1474-4422(14)70251-0
   Fornasari D, 2017, PAIN THER, V6, pS25, DOI 10.1007/s40122-017-0091-4
   Franco JVA, 2019, BJU INT, V124, P197, DOI 10.1111/bju.14492
   Gajraj NM, 2007, ANESTH ANALG, V105, P1805, DOI 10.1213/01.ane.0000287643.13410.5e
   Jiang JY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0085179
   Khattak AS, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.20243
   Krieger JN, 1999, JAMA-J AM MED ASSOC, V282, P236, DOI 10.1001/jama.282.3.236
   Krieger JN, 2008, INT J ANTIMICROB AG, V31, pS85, DOI 10.1016/j.ijantimicag.2007.08.028
   Lee SWH, 2014, COMPLEMENT THER MED, V22, P965, DOI 10.1016/j.ctim.2014.10.010
   Lee SWH, 2008, AM J MED, V121, DOI 10.1016/j.amjmed.2007.07.033
   Li JJ, 2020, PAIN RES MANAG, V2020, DOI 10.1155/2020/5921038
   Litwin MS, 1999, J UROLOGY, V162, P369, DOI 10.1016/S0022-5347(05)68562-X
   Miller LJ, 2002, UROLOGY, V59, P603, DOI 10.1016/S0090-4295(01)01597-7
   Nickel JC, 2010, BJU INT, V106, P1252, DOI 10.1111/j.1464-410X.2010.09701.x
   Pirola GM, 2019, RES REP UROL, V11, P165, DOI 10.2147/RRU.S194679
   Pontari MA, 2005, BJU INT, V96, P559, DOI 10.1111/j.1464-410X.2005.05684.x
   Pontari MA, 2004, J UROLOGY, V172, P839, DOI 10.1097/01.ju.0000136002.76898.04
   Pontari MA, 2010, ARCH INTERN MED, V170, P1586, DOI 10.1001/archinternmed.2010.319
   Qin ZS, 2022, ECLINICALMEDICINE, V48, DOI 10.1016/j.eclinm.2022.101457
   Rees J, 2015, BJU INT, V116, P509, DOI 10.1111/bju.13101
   Scholz J, 2019, PAIN, V160, P53, DOI 10.1097/j.pain.0000000000001365
   Strauss AC, 2010, NAT REV UROL, V7, P127, DOI 10.1038/nrurol.2010.4
   van Velzen M, 2020, FRONT PAIN RES, V1, DOI 10.3389/fpain.2020.00001
   Woodworth D, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140250
   Yang CC, 2003, J UROLOGY, V170, P823, DOI 10.1097/01.ju.0000082710.47402.03
   Zhang JZ, 2020, AM J MENS HEALTH, V14, DOI 10.1177/1557988320903200
   Zhang N, 2005, P NATL ACAD SCI USA, V102, P4536, DOI 10.1073/pnas.0406030102
NR 38
TC 0
Z9 0
U1 4
U2 8
PU SESTRE MILOSRDNICE UNIV HOSPITAL
PI ZAGREB
PA VINOGRADSKA C 29, ZAGREB, HR-10000, CROATIA
SN 0353-9466
EI 1333-9451
J9 ACTA CLIN CROAT
JI Acta Clin. Croat.
PY 2024
VL 63
SU 2
BP 63
EP 70
DI 10.20471/acc.2024.63.s2.10
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA P3Y3Q
UT WOS:001377301500010
DA 2026-01-16
ER

PT J
AU Lu, ZX
   Moody, J
   Marx, BL
   Hammerstrom, T
AF Lu, Zhaoxue
   Moody, Jennifer
   Marx, Benjamin L.
   Hammerstrom, Tracy
TI Treatment of Chemotherapy-Induced Peripheral Neuropathy in Integrative
   Oncology: A Survey of Acupuncture and Oriental Medicine Practitioners
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE acupuncture; chemotherapy-induced peripheral neuropathy; integrative
   oncology; neurological pain; neuropathic pain
ID SYMPTOM MANAGEMENT; PALLIATIVE CARE; CANCER CARE; PREVENTION; THERAPIES;
   TAXANES; TRIAL
AB Objectives: Complementary and alternative medicine is increasingly integrated into cancer care. We sought detail on the treatment of chemotherapy-induced peripheral neuropathy (CIPN) with acupuncture and oriental medicine (AOM) by surveying practitioners at integrative oncology (IO) sites across the United States.
   Design: Online survey of licensed acupuncturists.
   Setting/Location: IO sites in the United States.
   Subjects: Fifteen licensed acupuncturists who completed the survey between February 2014 and June 2014.
   Outcome measures: Demographics, IO setting characteristics, AOM treatment characteristics, and practitioner-reported outcomes.
   Results: Respondents reported an average of 31.317.2 patients per week, and one-third (10.1 mean; 7.2 standard deviation [SD]) were treated for CIPN. Medical doctors (86.7%) were the most common providers with whom respondents worked. Traditional Chinese medicine style acupuncture was utilized by a majority of respondents (86.7%), and the most commonly used points were local, typically in the hands and feet, such as Ba Feng, Ba Xie, LV3, and LI4. In addition to acupuncture, nutritional advice was the most frequent auxiliary modality provided by respondents (85.7%). On average, respondents provided 12.75 +/- 4.17 treatments for CIPN patients, and a majority (53%) reported treating patients once per week. Timing of the treatments relative to chemotherapy infusion was evenly distributed between "1-2 days after infusion (60%), "at time of infusion (53.3%), and "1-2 days before infusion (46.7%). Sixty percent of respondents rated outcomes as moderately successful with moderate improvement seen.
   Conclusion: This survey provides detail regarding IO sites using acupuncture for CIPN as well as real-world treatment patterns, including common point combinations, visit characteristics, and practitioner-reported outcomes. This information contributes to the emerging evidence on the use of acupuncture to address unmet needs of CIPN patients, and supports the development of best practice guidelines for the treatment of CIPN with acupuncture in the IO setting.
C1 [Lu, Zhaoxue; Moody, Jennifer; Marx, Benjamin L.; Hammerstrom, Tracy] Oregon Coll Oriental Med, Portland, OR USA.
RP Marx, BL (corresponding author), Oregon Coll Oriental Med, Res Dept, 75 NW Couch St, Portland, OR 97209 USA.
EM bmarx@ocom.edu
OI Marx, Benjamin/0000-0003-3865-2672
CR Albers JW, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005228.pub4
   [Anonymous], 2017, WHO | Cancer
   [Anonymous], EVID BASED COMPLEMEN
   Bao T, 2011, PAIN RES TREAT, V2011, DOI 10.1155/2011/920807
   Ben-Arye E, 2016, COMPLEMENT THER MED, V29, P9, DOI 10.1016/j.ctim.2016.09.001
   Boon Heather S, 2007, BMC Womens Health, V7, P4, DOI 10.1186/1472-6874-7-4
   Chao LF, 2009, BREAST CANCER RES TR, V118, P255, DOI 10.1007/s10549-009-0533-8
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Ewertz M, 2015, ACTA ONCOL, V54, P587, DOI 10.3109/0284186X.2014.995775
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Haddad NE, 2014, INTEGR CANCER THER, V13, P371, DOI 10.1177/1534735413520181
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Hile ES, 2010, PHYS THER, V90, P1649, DOI 10.2522/ptj.20090405
   Hu CQ, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1720239
   Javdan B, 2015, J ACUPUNCT MERIDIAN, V8, P115, DOI 10.1016/j.jams.2015.03.005
   KIM SY, 2016, EVID-BASED COMPL ALT, V2016
   Langevin HM, 2001, FASEB J, V15, P2275, DOI 10.1096/fj.01-0015hyp
   Lau CHY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002901
   Ling WM, 2014, ONCOL NURS FORUM, V41, P581, DOI 10.1188/14.ONF.581-592
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Majithia N, 2016, SUPPORT CARE CANCER, V24, P1439, DOI 10.1007/s00520-015-3063-4
   Mao JJ, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-7
   O'Sullivan EM, 2010, ACUPUNCT MED, V28, P191, DOI 10.1136/aim.2010.002733
   Paice Judith A, 2009, Semin Oncol Nurs, V25, pS8, DOI 10.1016/j.soncn.2009.03.013
   Park SB, 2013, CA-CANCER J CLIN, V63, P419, DOI 10.3322/caac.21204
   Rivera E, 2015, CANCER CHEMOTH PHARM, V75, P659, DOI 10.1007/s00280-014-2607-5
   Schloss J, 2016, ASIA-PAC J ONCOL NU, V3, P73, DOI 10.4103/2347-5625.170977
   Schneider BP, 2015, ADV EXP MED BIOL, V862, P77, DOI 10.1007/978-3-319-16366-6_6
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Towler P, 2013, SUPPORT CARE CANCER, V21, P2913, DOI 10.1007/s00520-013-1882-8
   Tsuchiya M, 2007, ANESTH ANALG, V104, P301, DOI 10.1213/01.ane.0000230622.16367.fb
   Valentine-Davis B, 2015, MED ACUPUNCT, V27, P216, DOI 10.1089/acu.2015.1103
   Wong Raimond, 2006, Acupunct Med, V24, P87
   Wong R, 2016, INTEGR CANCER THER, V15, P153, DOI 10.1177/1534735415627926
   Wu XY, 2015, SCI REP-UK, V5, DOI 10.1038/srep16776
   Xu Wei-Ru, 2010, Zhongguo Zhen Jiu, V30, P457
   Yao C, 2016, CURR ONCOL, V23, pE27, DOI 10.3747/co.23.2788
NR 39
TC 19
Z9 21
U1 1
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD DEC
PY 2017
VL 23
IS 12
BP 964
EP 970
DI 10.1089/acm.2017.0052
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FQ6FZ
UT WOS:000418460500010
PM 28661695
DA 2026-01-16
ER

PT J
AU Ye, JN
   Su, CG
   Jiang, YQ
   Zhou, Y
   Sun, WX
   Zheng, XX
   Miao, JT
   Li, XY
   Zhu, J
AF Ye, Jiang-nan
   Su, Cheng-guo
   Jiang, Yu-qing
   Zhou, Yan
   Sun, Wen-xi
   Zheng, Xiao-xia
   Miao, Jin-tao
   Li, Xiang-yue
   Zhu, Jun
TI Effects of acupuncture on cartilage p38MAPK and mitochondrial pathways
   in animal model of knee osteoarthritis: A systematic evaluation and
   meta-analysis
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE knee osteoarthritis; acupuncture; animal models; p38MAPK pathways;
   mitochondrial pathways; cytokines; meta-analysis
ID DEGENERATION; INFLAMMATION; APOPTOSIS; KINASES; PAIN
AB Background: Most previous studies on acupuncture in the treatment of knee osteoarthritis (KOA) have focused on improving functional efficacy and safety, while related mechanisms have not been systematically reviewed. Acupuncture modulates cytokines to attenuate cartilage extracellular matrix degradation and apoptosis, key to the pathogenesis of KOA, but the mechanisms are complex.Objectives: The purpose of this study is to assess the efficacy of acupuncture quantitatively and summarily in animal studies of KOA.Methods: Nine databases including PubMed, Embase, Web of Science (including Medline), Cochrane library, Scopus, CNKI, Wan Fang, and VIP were searched to retrieve animal studies on acupuncture interventions in KOA published since the inception of the journal. Relevant literature was screened, and information extracted. Meta-analysis was performed using Revman 5.4 and Stata 17.0 software.Results: The 35 included studies involved 247 animals, half of which were in acupuncture groups and half in model groups. The mean quality level was 6.7, indicating moderate quality. Meta-analysis showed that acupuncture had the following significant effects on cytokine levels in p38MAPK and mitochondrial pathways: (1) p38MAPK pathway: It significantly inhibits p38MAPK, interleukin-1beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), phosphorylated (p)-p38MAPK, matrix metalloproteinase-13 (MMP-13), MMP-1, a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMST-5) expression, and significantly increased the expression of collagen II and aggrecan. (2) mitochondrial pathway: It significantly inhibited the expression of Bcl-2-associated X protein (Bax), cysteine protease-3 (caspase-3), caspase-9, and Cytochrome-c (Cyt-c). And significantly increased the expression of B cell lymphocytoma-2 (Bcl-2). In addition, acupuncture significantly reduced chondrocyte apoptosis, Mankin's score (a measure of cartilage damage), and improved cartilage morphometric characteristics.Conclusion: Acupuncture may inhibit cytokine expression in the p38MAPK pathway to attenuate cartilage extracellular matrix degradation, regulate cytokines in the mitochondrial pathway to inhibit chondrocyte apoptosis, and improve cartilage tissue-related phenotypes to delay cartilage degeneration. These findings provide possible explanations for the therapeutic mechanisms and clinical benefits of acupuncture for KOA.
C1 [Ye, Jiang-nan; Su, Cheng-guo; Jiang, Yu-qing; Miao, Jin-tao; Li, Xiang-yue; Zhu, Jun] Chengdu Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Chengdu, Peoples R China.
   [Zhou, Yan] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China.
   [Sun, Wen-xi; Zheng, Xiao-xia] Guangzhou Univ Chinese Med, Grad Sch, Guangzhou, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Xiyuan Hospital,
   CACMS; China Academy of Chinese Medical Sciences; Guangzhou University
   of Chinese Medicine
RP Zhu, J (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Chengdu, Peoples R China.
EM zhujuntcm@163.com
RI ; Sun, Wen-xi/IUO-3114-2023
OI YE, Jiang-nan/0000-0003-4081-5936; Sun, Wen-xi/0000-0002-5855-5223
FU National Natural Science Foundation of China [81704152, 82004497]; Key
   Research and Development Project of Sichuan Provincial Science and
   Technology Department [23ZDYF1797]
FX Funding This study was supported by the National Natural Science
   Foundation of China (81704152 and 82004497), and the Key Research and
   Development Project of Sichuan Provincial Science and Technology
   Department (23ZDYF1797).
CR Bannuru RR, 2019, OSTEOARTHR CARTILAGE, V27, P1578, DOI 10.1016/j.joca.2019.06.011
   Bao Fei, 2011, Zhongguo Zhen Jiu, V31, P241
   Bedenbaugh AV, 2021, CLINICOECONOMIC OUTC, V13, P421, DOI 10.2147/CEOR.S302289
   Brown KK, 2008, J INFLAMM-LOND, V5, DOI 10.1186/1476-9255-5-22
   Chen J., 2020, EXP THER MED, V42, P1100
   Chen R., 2021, INVESTIGATE MECH ELE
   Corbett MS, 2013, OSTEOARTHR CARTILAGE, V21, P1290, DOI 10.1016/j.joca.2013.05.007
   Fu Ni-Ni, 2016, Sichuan Da Xue Xue Bao Yi Xue Ban, V47, P708
   [付妮妮 Fu Nini], 2016, [中国康复理论与实践, Chinese Journal of Rehabilitation Theory and Practice], V22, P38
   Goldring MB, 2015, CURR OPIN PHARMACOL, V22, P51, DOI 10.1016/j.coph.2015.03.004
   Hao X. W., 2022, CHINESE J CATAL, P1
   He L, 2020, STEM CELL RES THER, V11, DOI 10.1186/s13287-020-01781-w
   Hinman RS, 2014, JAMA-J AM MED ASSOC, V312, P1313, DOI 10.1001/jama.2014.12660
   Hunziker EB, 2015, OSTEOARTHR CARTILAGE, V23, P334, DOI 10.1016/j.joca.2014.12.011
   Kapoor M, 2011, NAT REV RHEUMATOL, V7, P33, DOI 10.1038/nrrheum.2010.196
   Kolasinski SL, 2020, ARTHRITIS RHEUMATOL, V72, P220, DOI [10.1002/art.41142, 10.1002/acr.24131]
   Lee S, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.878463
   Li A, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000013655
   Liang C. X., 2015, APOPTOSIS
   Liang Chu-Xi, 2015, Zhen Ci Yan Jiu, V40, P119
   Liao Y, 2016, ACUPUNCT MED, V34, P290, DOI 10.1136/acupmed-2015-010949
   Lieberthal J, 2015, OSTEOARTHR CARTILAGE, V23, P1825, DOI 10.1016/j.joca.2015.08.015
   [林道冠 Lin Daoguan], 2019, [中国免疫学杂志, Chinese Journal of Immunology], V35, P2730
   Lin LL, 2020, PAIN, V161, P2532, DOI 10.1097/j.pain.0000000000001940
   Liu D., 2017, CHINESE MED J-PEKING, V44, P2652
   Liu D, 2021, J TRADIT CHIN MED, V41, P959, DOI 10.19852/j.cnki.jtcm.2021.06.013
   Liu H, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/2470182
   Liu J. W., 2019, EVID-BASED COMPL ALT
   Liu JW, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5523726
   Liu Nai-Gang, 2018, Zhen Ci Yan Jiu, V43, P221, DOI 10.13702/j.1000-0607.170890
   Ma SN, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/4535326
   Mehana ESE, 2019, LIFE SCI, V234, DOI 10.1016/j.lfs.2019.116786
   Moskowitz RW, 2006, OSTEOARTHR CARTILAGE, V14, P1, DOI 10.1016/j.joca.2005.08.015
   Murphy SP, 2010, J NEUROCHEM, V115, P805, DOI 10.1111/j.1471-4159.2010.06998.x
   Page MJ, 2021, REV ESP CARDIOL, V74, P790, DOI [10.1016/j.recesp.2021.06.016, 10.1016/j.rec.2021.07.010]
   Pallante AL, 2009, AM J SPORT MED, V37, p24S, DOI 10.1177/0363546509351496
   Park C, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082308
   Qin LX, 2022, J TRADIT CHIN MED, V42, P389, DOI 10.19852/j.cnki.jtcm.2022.03.006
   Reinhold T, 2008, EUR J HEALTH ECON, V9, P209, DOI 10.1007/s10198-007-0062-5
   Ritskes-Hoitinga M, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000078
   Schindler JF, 2007, J DENT RES, V86, P800, DOI 10.1177/154405910708600902
   Sun FF, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/4695381
   Thomas BL, 2021, J EXTRACELL VESICLES, V10, DOI 10.1002/jev2.12088
   Tong J, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/2047097
   Tu JF, 2021, ARTHRITIS RHEUMATOL, V73, P448, DOI 10.1002/art.41584
   Vakifahmetoglu-Norberg H, 2017, BIOCHEM BIOPH RES CO, V482, P426, DOI 10.1016/j.bbrc.2016.11.088
   Vina ER, 2021, ACR OPEN RHEUMATOL, V3, P660, DOI 10.1002/acr2.11307
   [万超 Wan Chao], 2021, [中国中医基础医学杂志, Chinese Journal of Basic Medicine in Traditional Chinese Medicine], V27, P432
   Wan Chao, 2019, Zhongguo Zhen Jiu, V39, P409, DOI 10.13703/j.0255-2930.2019.04.017
   Wang B., 2020, FRONT PHARMACOL
   Wang D., 2021, J NINGXIA MED U, V43, P1179
   Wang MN, 2013, ARTHRITIS RES THER, V15, DOI 10.1186/ar4133
   Wang R, 2021, STEM CELL RES THER, V12, DOI 10.1186/s13287-021-02533-0
   Wang ZK, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/5476064
   Wu GW, 2019, CHIN J INTEGR MED, V25, P677, DOI 10.1007/s11655-018-2916-8
   Wu Y. L., 2018, CHIN J INTEGR TRADIT, V37, P1372
   Wu Y. L., 2022, TISSUE ENG, V26
   Xi Xiaofang, 2016, Zhongguo Zhen Jiu, V36, P1288, DOI 10.13703/j.0255-2930.2016.12.017
   Xie JW, 2021, AGEING RES REV, V70, DOI 10.1016/j.arr.2021.101413
   Xiong Y., 2012, CHIN J TISSUE ENG RE, V16
   Yu J. N., 2016, EFFECT ACUPOTOMY ADJ
   Zeng W. Q., 2021, REV SCI INSTRUM, V52, P19
   Zhang XH, 2014, DRUG DEVELOP RES, V75, P195, DOI 10.1002/ddr.21170
   Zhang Yuan-Yuan, 2019, Zhongguo Zhen Jiu, V39, P1081, DOI 10.13703/j.0255-2930.2019.10.013
   [张媛媛 Zhang Yuanyuan], 2019, [康复学报, Rehabilitation Medicine], V29, P30
   Zhou J, 2018, ACUPUNCT MED, V36, P37, DOI 10.1136/acupmed-2016-011258
   Zhou Y, 2015, APOPTOSIS, V20, P1187, DOI 10.1007/s10495-015-1152-y
   Zhu D.Y., 2021, CHINESE MED J-PEKING, V13, P7
   Zhu S.Q., 2021, J CLIN INVEST, V25
NR 69
TC 6
Z9 8
U1 2
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD JAN 11
PY 2023
VL 16
AR 1098311
DI 10.3389/fnins.2022.1098311
PG 18
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 8T7LK
UT WOS:000929438400001
PM 36711149
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhu, XY
   Li, Z
   Chen, C
   Feng, RL
   Cheng, BR
   Liu, RY
   Wang, RT
   Xu, L
   Wang, Y
   Tao, X
   Zhao, P
AF Zhu, Xue-Ying
   Li, Zhong
   Chen, Cong
   Feng, Ru-Li
   Cheng, Bai-Ru
   Liu, Ruo-Yi
   Wang, Rui-Ting
   Xu, Li
   Wang, Yue
   Tao, Xin
   Zhao, Peng
TI Physical Therapies for Psychosomatic Symptoms and Quality of Life
   Induced by Aromatase Inhibitors in Breast Cancer Patients: A Systematic
   Review and Meta-Analysis
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE physical therapies; acupuncture; exercise; breast cancer; aromatase
   inhibitors; pain; quality of life
ID RANDOMIZED CONTROLLED-TRIAL; CLINICAL-PRACTICE GUIDELINE;
   MUSCULOSKELETAL SYMPTOMS; INDUCED ARTHRALGIA; DOUBLE-BLIND; DUAL-CENTER;
   EXERCISE; WOMEN; ACUPUNCTURE; PAIN
AB Objective: To evaluate the effects of Physical Therapies (PTs) on improvement in psychosomatic symptoms and quality of life (QOL) in breast cancer patients.
   Data Sources: Seven databases (MEDLINE, EMBASE, Cochrane CENTRAL, China National Knowledge Infrastructure, Wangfang, VIP, and China Biology Medicine disc databases) were systematically searched from the database inception through May 18, 2021.
   Study Selection: Randomized controlled trials (RCTs) which compared acupuncture or exercise with a sham control or usual care for the treatment of aromatase inhibitors (AIs)-related psychosomatic symptoms and QOL.
   Data Extraction and Synthesis: Data were screened and extracted independently using predesigned forms. The quality of RCTs was assessed with the Cochrane Handbook for Systematic Reviews of Interventions. The effect size was calculated via random-effects modeling. The quality of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation approach.
   Main Outcomes and Measures: The score of pain was measured with BPI scale and Western Ontario and the McMaster Universities Index (WOMAC) scale. Emotional state was measured with Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS-A), and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue). The QOL score was measured by self-reported measurements, including the Functional Assessment of Cancer Therapy-General (FACT-G) scale and 36-Item Short Form Survey (SF-36) scale.
   Results: Eleven RCTs (with 830 patients) were included in the systematic review, and data from 10 RCTs (with 798 patients) were used in the meta-analysis. Results showed acupuncture significantly reduced worst pain scores (P < 0.00001, I (2) = 83.5%) [SMD = -0.81, 95% CI (-1.51, -0.11)], but the effect of exercise therapies was not significant in overall change in worst pain scores (P =0.006, I (2) = 72.3%) [SMD = -0.30, 95% CI (-0.76, 0.16)]. Both acupuncture and exercise resulted in little to no difference in overall change in HADS-A subscale (P = 0.026 < 0.05, I (2) = 79.8%) [WMD = -0.21, 95% CI (-3.44, 3.03)], PSQI subscale (P = 0.488, I (2) = 0%) [WMD = 0.98, 95% CI (-0.57, 2.53)], and FACIT-Fatigue subscale (P = 0.022 < 0.05, I (2) = 81.0%) [WMD = 1.6, 95% CI (-5.75, 8.94)]. Exercise (compared with usual care) was associated with improving overall change in health-related QOL (subscales of SF-36 tool) (P = 0, I (2) = 72.1%) [WMD = 7.97, 95% CI (5.68, 10.25)] and cancer-specific QOL (subscales of FACT-G tool) (P = 0.304, I (2) = 16%) [WMD = 1.16, 95% CI (0.34, 1.97)].
   Conclusions and Relevance: This systematic review and meta-analysis suggested that based on moderate-level evidence, acupuncture was associated with significant reductions in pain intensity, and exercise might improve QOL in breast cancer patients treated with AIs. However, in psychosomatic symptoms such as anxiety, sleep disturbance, and fatigue, acupuncture and exercise training did not result in significant improvements.
C1 [Zhu, Xue-Ying; Li, Zhong] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Oncol, Beijing, Peoples R China.
   [Chen, Cong; Feng, Ru-Li; Cheng, Bai-Ru; Wang, Rui-Ting; Zhao, Peng] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Cardiol, Beijing, Peoples R China.
   [Liu, Ruo-Yi] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Encephalopathy, Beijing, Peoples R China.
   [Xu, Li] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Gynecol, Beijing, Peoples R China.
   [Wang, Yue] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
   [Tao, Xin] Capital Med Univ, Sch Med Humanities, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine; Beijing University of
   Chinese Medicine; Beijing University of Chinese Medicine; Capital
   Medical University
RP Zhao, P (corresponding author), Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Cardiol, Beijing, Peoples R China.
EM kyushuzhaopeng@hotmail.com
RI ruiting, wang/JPY-3276-2023; Cheng, Bairu/AAA-1064-2022; Liu,
   Ruoyi/LWK-3777-2024; Feng, Ruli/GXW-2134-2022
OI Cheng, Bairu/0000-0002-2216-9195; Feng, Ruli/0000-0001-6741-0870
FU 2020 Dongzhimen Hospital Affiliated to Beijing University of Chinese
   Medicine Science and Technology Innovation Special Fund
   [DZMKJCX-2020-027]
FX Funding This work was supported by the 2020 Dongzhimen Hospital
   Affiliated to Beijing University of Chinese Medicine Science and
   Technology Innovation Special Fund (DZMKJCX-2020-027).
CR Baglia ML, 2019, CANCER-AM CANCER SOC, V125, P2262, DOI 10.1002/cncr.32051
   Baker MK, 2018, INTEGR CANCER THER, V17, P968, DOI 10.1177/1534735418781489
   Bao T, 2014, CANCER-AM CANCER SOC, V120, P381, DOI 10.1002/cncr.28352
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   BASBAUM AI, 1978, ANN NEUROL, V4, P451, DOI 10.1002/ana.410040511
   Beckwée D, 2017, SUPPORT CARE CANCER, V25, P1673, DOI 10.1007/s00520-017-3613-z
   Boing L, 2020, MATURITAS, V141, P71, DOI 10.1016/j.maturitas.2020.06.022
   Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21609, 10.3322/caac.21492]
   Brown JC, 2014, BREAST J, V20, P22, DOI 10.1111/tbj.12202
   Burstein HJ, 2014, J CLIN ONCOL, V32, P2255, DOI 10.1200/JCO.2013.54.2258
   Campbell KL, 2019, MED SCI SPORT EXER, V51, P2375, DOI 10.1249/MSS.0000000000002116
   CASPERSEN CJ, 1985, PUBLIC HEALTH REP, V100, P126, DOI 10.1016/j.jclinepi.2013.11.007
   Chavooshi B, 2017, PSYCHOSOMATICS, V58, P506, DOI 10.1016/j.psym.2017.01.003
   Chen WQ, 2016, CA-CANCER J CLIN, V66, P115, DOI 10.3322/caac.21338
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Chou R, 2007, ANN INTERN MED, V147, P478, DOI 10.7326/0003-4819-147-7-200710020-00006
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Faller H, 2013, J CLIN ONCOL, V31, P782, DOI 10.1200/JCO.2011.40.8922
   Fields J, 2016, J PAIN SYMPTOM MANAG, V52, P548, DOI 10.1016/j.jpainsymman.2016.03.010
   Foldi J, 2021, CURR TREAT OPTION ON, V22, DOI 10.1007/s11864-021-00879-4
   Gentry AL, 2018, CONTEMP CLIN TRIALS, V67, P109, DOI 10.1016/j.cct.2018.02.012
   Gradishar W, 2016, J NATL COMPR CANC NE, V14, P641, DOI 10.6004/jnccn.2016.0181
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hershman DL, 2015, ADV EXP MED BIOL, V862, P89, DOI 10.1007/978-3-319-16366-6_7
   Hershman DL, 2011, BREAST CANCER RES TR, V126, P529, DOI 10.1007/s10549-010-1132-4
   Invernizzi M, 2022, ANTI-CANCER AGENT ME, V22, P801, DOI 10.2174/1871520621666210609095602
   Invernizzi M, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.556718
   Irwin ML, 2015, J CLIN ONCOL, V33, P1104, DOI 10.1200/JCO.2014.57.1547
   Kemp-Casey A, 2017, ASIA-PAC J CLIN ONCO, V13, pE161, DOI 10.1111/ajco.12600
   Khosravi N, 2019, BRAIN BEHAV IMMUN, V81, P92, DOI 10.1016/j.bbi.2019.08.187
   Koual M, 2020, ENVIRON HEALTH-GLOB, V19, DOI 10.1186/s12940-020-00670-2
   Liberati Alessandro, 2009, PLoS Med, V6, pe1000100, DOI 10.1371/journal.pmed.1000100
   Liu XM, 2021, INTEGR CANCER THER, V20, DOI 10.1177/1534735420980811
   Lu GL, 2020, SUPPORT CARE CANCER, V28, P1587, DOI 10.1007/s00520-019-05186-1
   Mandelblatt JS, 2013, SEMIN ONCOL, V40, P709, DOI 10.1053/j.seminoncol.2013.09.006
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Mehnert A, 2014, J CLIN ONCOL, V32, P3540, DOI 10.1200/JCO.2014.56.0086
   Meneses-Echávez JF, 2016, CANCER EPIDEM BIOMAR, V25, P1009, DOI 10.1158/1055-9965.EPI-15-1061
   Miglietta F, 2021, CANCER TREAT REV, V98, DOI 10.1016/j.ctrv.2021.102222
   Möller UO, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-5648-7
   Nadji M, 2005, AM J CLIN PATHOL, V123, P21, DOI 10.1309/4WV79N2GHJ3X1841
   Nahm Nicole, 2018, Asia Pac J Clin Oncol, V14, P374, DOI 10.1111/ajco.12845
   Newton RU, 2019, MED J AUSTRALIA, V210, DOI 10.5694/mja2.12043
   Nyrop KA, 2017, ONCOLOGIST, V22, P1238, DOI 10.1634/theoncologist.2017-0174
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Paulo TRS, 2019, HEALTH QUAL LIFE OUT, V17, DOI 10.1186/s12955-019-1090-4
   Ramírez-Vélez R, 2021, CANCERS, V13, DOI 10.3390/cancers13020264
   Roberts K, 2017, CRIT REV ONCOL HEMAT, V111, P66, DOI 10.1016/j.critrevonc.2017.01.010
   Roberts KE, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012988.pub2
   Saanijoki T, 2018, NEUROPSYCHOPHARMACOL, V43, P246, DOI 10.1038/npp.2017.148
   Schmidt T, 2017, J CANCER RES THER, V13, P392, DOI 10.4103/0973-1482.150356
   Stout NL, 2017, PM&R, V9, pS347, DOI 10.1016/j.pmrj.2017.07.074
   Swieboda P, 2013, ANN AGR ENV MED, P2
   Tenti S, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21165625
   Weis JB, 2020, SUPPORT CARE CANCER, V28, P3033, DOI 10.1007/s00520-019-05076-6
   Xiao LJ, 2017, ADV EXP MED BIOL, V1010, P247, DOI 10.1007/978-981-10-5562-1_12
   Zhang XY, 2019, SUPPORT CARE CANCER, V27, P9, DOI 10.1007/s00520-018-4363-2
   Zidkova R, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18073570
NR 60
TC 15
Z9 17
U1 1
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD NOV 12
PY 2021
VL 11
AR 745280
DI 10.3389/fonc.2021.745280
PG 16
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology
GA XH6XB
UT WOS:000725574000001
PM 34868943
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Viel, E
   Vanoli, A
   Melis, A
   Rocher, F
   Schipman, B
   Truong, D
AF Viel, E.
   Vanoli, A.
   Melis, A.
   Rocher, F.
   Schipman, B.
   Truong, D.
TI Efficiency of auricular acupuncture in climacteric symptoms after cancer
   treatments
SO CLIMACTERIC
LA English
DT Article
DE Auricular acupuncture; auriculotherapy; hot flushes; cancer
ID WOMEN; PAIN
AB Objectives: This paper aims to highlight the efficiency of auriculotherapy in the treatment of hot flushes, especially in cancer-related menopausal transition.Methods: We used systematically collected data from patients in 2014 in a medical oncology practice. The treatment was made according to the guidelines of The Inter-University Diploma and the cartography of the World Health Organization; data on satisfaction were collected orally.Results: In 2014, 49 patients, among whom 41 had cancer, were treated for hot flushes. Although it is not recommended to treat several symptoms during the same session, we dealt with 1.7 symptoms per session on average. Sixty-nine percent of the patients were satisfied. We lacked data for nine patients, who did not come to the minimal recommended number of treatments (three). Only one patient among those who did not observe any improvement received three treatments.Conclusions: Auricular acupuncture is a safe and cheap method to treat hot flushes. It has been effective in numerous and various cases, among which were patients who presented cancer-related menopausal symptoms. It may be applied for a large variety of other symptoms.
C1 [Rocher, F.; Schipman, B.] Oncol & Radiotherapy Ctr Du Parc, Chalon Sur Saone, France.
RP Viel, E (corresponding author), 4 Allees St Jean des Vignes, F-71100 Chalon Sur Saone, France.
EM viel.erika@orange.fr
CR Alimi D, 2000, J PAIN SYMPTOM MANAG, V19, P81, DOI 10.1016/S0885-3924(99)00140-2
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Alimi D., 2002, MED ACUPUNCT, V13, P18
   [Anonymous], CANC NURS
   [Anonymous], EVID BASED COMPLEMEN
   Chiu HY, 2015, MENOPAUSE, V22, P234, DOI [10.1097/gme.0000000000000260, 10.1097/GME.0000000000000260]
   Cho ZH, 2002, J ALTERN COMPLEM MED, V8, P399, DOI 10.1089/107555302760253577
   Holzbeierlein JM, 2004, CURR OPIN UROL, V14, P177, DOI 10.1097/00042307-200405000-00007
   Huntley AL, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/850429
   Kyvernitakis I, 2014, CLIMACTERIC, V17, P252, DOI 10.3109/13697137.2013.819327
   Luparello V, 1994, REV FRANC AISE MED T, V162, P62
   Münstedt K, 2015, MOL CLIN ONCOL, V3, P869, DOI 10.3892/mco.2015.559
   Park H, 2011, SUPPORT CARE CANCER, V19, P859, DOI 10.1007/s00520-011-1099-7
NR 13
TC 3
Z9 4
U1 0
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD JUN
PY 2016
VL 19
IS 3
BP 274
EP 278
DI 10.3109/13697137.2016.1164135
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA DL8CF
UT WOS:000375866300013
PM 27102586
DA 2026-01-16
ER

PT J
AU Chen, YF
   Tian, SA
   Tian, J
   Shu, S
AF Chen, Yingfan
   Tian, Sinan
   Tian, Jing
   Shu, Shi
TI Wrist-ankle acupuncture (WAA) for primary dysmenorrhea (PD) of young
   females: study protocol for a randomized controlled trial
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Wrist-ankle acupuncture (WAA); Primary dysmenorrheal (PD); Randomized
   controlled trial
ID MANAGEMENT; CANCER
AB Background: Primary dysmenorrhea (PD) is one of the most common health complaints all over the world, specifically among young females. Acupuncture has been employed to relieve the pain-based symptoms and to avoid the side effects of conventional medication, and wrist-ankle acupuncture (WAA) has confirmed analgesic efficacy for various types of pain. The aim of this study is to evaluate the immediate analgesia effect of WAA on PD of young females.
   Methods/design: This study will carry out a randomized parallel controlled single-blind trial to observe the immediate analgesia effect of WAA in PD of young females. Sixty participants who meet inclusion criteria will be recruited from September 2016 to September 2017 in Changhai hospital of China. They are randomly assigned to WAA therapy or sham acupuncture groups (30 patients for each group), and then receive real or sham acupuncture treatment, respectively. In this trial, the primary outcome measure is simple form of McGill pain questionnaire (SF-MPQ), while expectation and treatment credibility scale (ETCS), safety assessment, the COX menstrual symptom scale (CMSS), questionnaire about the feeling of being punctured are included in the secondary outcomes.
   Discussion: This trial will be the first study protocol designed to evaluate the immediate analgesia effect of WAA in PD of young females. The strengths in methodology, including rigorous randomized, sham-controlled, participants-blinded and assessors-blinded, will guarantee the quality of this study. WAA doesn't require any needling sensation, so nonpenetrating sham acupuncture can serve as an effective placebo intervention in this trial.
C1 [Chen, Yingfan; Tian, Sinan; Shu, Shi] Second Mil Med Univ, Changhai Hosp Tradit Chinese Med, 168 Changhai Rd, Shanghai, Peoples R China.
   [Tian, Jing] Second Mil Med Univ, Dept Nursing Sci, Shanghai, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Shu, S (corresponding author), Second Mil Med Univ, Changhai Hosp Tradit Chinese Med, 168 Changhai Rd, Shanghai, Peoples R China.
EM shushitcm@163.com
OI Shu, Shi/0000-0002-0092-2465
FU Incubation of Acupuncture and Tuina, Second Military Medical University
FX This work was supported by Incubation of Acupuncture and Tuina, Second
   Military Medical University.
CR Dawood MY, 2006, OBSTET GYNECOL, V108, P428, DOI 10.1097/01.AOG.0000230214.26638.0c
   French L., 2005, AM FAM PHYSICIAN, V12, P85
   Gemma M, 2015, J INTEGR MED-JIM, V13, P99, DOI 10.1016/S2095-4964(15)60159-5
   [胡侠 Hu Xia], 2004, [中国针灸, Chinese Acupuncture and Moxibustion], V24, P149
   [胡侠 Hu Xia], 2004, [中国针灸, Chinese Acupuncture and Moxibustion], V24, P361
   Kennedy S, 1997, LANCET, V349, P1116, DOI 10.1016/S0140-6736(05)63018-8
   Lao H.H., 1999, WRIST ANKLE ACUPUNCT, P1
   Lefebvre G, 2005, J OBSTET GYNAECOL CA, V27, P1117
   Li B, 2014, ADV MATER SCI ENG, V2014, DOI 10.1155/2014/510958
   Lin JG, 2012, AM J CHINESE MED, V40, P219, DOI 10.1142/S0192415X12500176
   Marra C, 2011, J ALTERN COMPLEM MED, V17, P239, DOI 10.1089/acm.2010.0256
   Nevatte T, 2013, ARCH WOMEN MENT HLTH, V16, P279, DOI 10.1007/s00737-013-0346-y
   Proctor M, 2006, BMJ-BRIT MED J, V332, P1134, DOI 10.1136/bmj.332.7550.1134
   Shu S, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0910-z
   Su Jiang-tao, 2010, Zhongguo Zhen Jiu, V30, P617
   To M, 2015, J INTEGR MED-JIM, V13, P20, DOI 10.1016/S2095-4964(15)60153-4
   Wang ZF, 2016, CHINESE J ETHNOMEDIC, V24, P50
   Xia HU, 2005, CHINESE J INTEGRATED, V15, P131
   Yang J, 2007, NERVOUS DIS MENTAL H, V7, P371
   Zeng K, 2014, AM J CHINESE MED, V42, P289, DOI 10.1142/S0192415X14500190
   Zhang WY, 1998, BRIT J OBSTET GYNAEC, V105, P780, DOI 10.1111/j.1471-0528.1998.tb10210.x
   Zhang X., 2002, Practical Wrist-ankle Acupuncture Therapy
   Zhou YL, 2017, CHINESE ACUPUNCTURE, V27, P923
   Zhu Z, 1998, J Tradit Chin Med, V18, P192
NR 24
TC 11
Z9 15
U1 1
U2 41
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD AUG 22
PY 2017
VL 17
AR 421
DI 10.1186/s12906-017-1923-9
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FE8KV
UT WOS:000408454900008
PM 28830511
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ma, Y
   Dong, M
   Zhou, KH
   Mita, C
   Liu, JP
   Wayne, PM
AF Ma, Yan
   Dong, Ming
   Zhou, Kehua
   Mita, Carol
   Liu, Jianping
   Wayne, Peter M.
TI Publication Trends in Acupuncture Research: A 20-Year Bibliometric
   Analysis Based on PubMed
SO PLOS ONE
LA English
DT Article
ID LOW-BACK-PAIN; CHINESE MEDICINE; PRIMARY-CARE; MANAGEMENT; QUALITY;
   METAANALYSIS; COMPLEMENTARY; LABOR
AB Objective
   Acupuncture has become popular and widely practiced in many countries around the world. Despite the large amount of acupuncture-related literature that has been published, broader trends in the prevalence and scope of acupuncture research remain underexplored. The current study quantitatively analyzes trends in acupuncture research publications in the past 20 years.
   Methods
   A bibliometric approach was used to search PubMed for all acupuncture-related research articles including clinical and animal studies. Inclusion criteria were articles published between 1995 and 2014 with sufficient information for bibliometric analyses. Rates and patterns of acupuncture publication within the 20 year observational period were estimated, and compared with broader publication rates in biomedicine. Identified eligible publications were further analyzed with respect to study type/design, clinical condition addressed, country of origin, and journal impact factor.
   Results
   A total of 13,320 acupuncture-related publications were identified using our search strategy and eligibility criteria. Regression analyses indicated an exponential growth in publications over the past two decades, with a mean annual growth rate of 10.7%. This compares to a mean annual growth rate of 4.5% in biomedicine. A striking trend was an observed increase in the proportion of randomized clinical trials (RCTs), from 7.4% in 1995 to 20.3% in 2014, exceeding the 4.5% proportional growth of RCTs in biomedicine. Over the 20 year period, tions). Other top rankings with respect to medical focus were arthritis, neoplasms/cancer, pregnancy or labor, mood disorders, stroke, nausea/vomiting, sleep, and paralysis/palsy. Acupuncture research was conducted in 60 countries, with the top 3 contributors being China (47.4%), United States (17.5%), and United Kingdom (8.2%). Retrieved articles were published mostly in complementary and alternative medicine (CAM) journals with impact factors ranging between 0.7 and 2.8 in the top 20 journals, followed by journals specializing in neuroscience, pain, anesthesia/analgesia, internal medicine and comprehensive fields.
   Conclusion
   Acupuncture research has grown markedly in the past two decades, with a 2-fold higher growth rate than for biomedical research overall. Both the increases in the proportion of RCTs and the impact factor of journals support that the quality of published research has improved. While pain was a consistently dominant research focus, other topics gained more attention during this time period. These findings provide a context for analyzing strengths and gaps in the current state of acupuncture research, and for informing a comprehensive strategy for further advancing the field.
C1 [Ma, Yan] PLA, Air Force Gen Hosp, Sleep Ctr, Beijing, Peoples R China.
   [Ma, Yan] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Interdisciplinary Med & Biotechnol, Boston, MA 02115 USA.
   [Dong, Ming] IBM Corp, Software Dev Lab, Littleton, MA USA.
   [Zhou, Kehua] Daemen Coll, Dept Hlth Care Studies, Amherst, NY USA.
   [Zhou, Kehua] Daemen Coll, Phys Therapy Wound Care Clin, Amherst, NY USA.
   [Mita, Carol] Harvard Med Sch, Countway Lib Med, Reference & Educ Serv, Boston, MA USA.
   [Liu, Jianping] Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing, Peoples R China.
   [Wayne, Peter M.] Brigham & Womens Hosp, Div Prevent Med, Osher Ctr Integrat Med, 75 Francis St, Boston, MA 02115 USA.
   [Wayne, Peter M.] Harvard Med Sch, Boston, MA USA.
C3 Air Force General Hospital PLA; Harvard University; Harvard University
   Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard
   Medical School; International Business Machines (IBM); IBM USA; Daemen
   University; Daemen University; Harvard University; Harvard Medical
   School; Beijing University of Chinese Medicine; Harvard University;
   Harvard University Medical Affiliates; Brigham & Women's Hospital;
   Harvard University; Harvard Medical School
RP Ma, Y (corresponding author), PLA, Air Force Gen Hosp, Sleep Ctr, Beijing, Peoples R China.; Ma, Y (corresponding author), Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Interdisciplinary Med & Biotechnol, Boston, MA 02115 USA.
EM dr.yan.ma@gmail.com
RI ; ZHOU, Kehua/N-2331-2014
OI MITA, CAROL/0000-0003-3059-1369; Ma, Yan/0000-0003-1173-2920; Liu,
   Jianping/0000-0002-0320-061X; 
CR Abaraogu UO, 2015, J ACUPUNCT MERIDIAN, V8, P220, DOI 10.1016/j.jams.2015.06.010
   [Anonymous], 2015, PUBMED HELP NCBI HEL
   [Anonymous], 2015, EVID BASED COMPLEMEN
   [Anonymous], 2014, COCHRANE DATABASE SY
   [Anonymous], 2014, MEDLINE PUBMED RES G
   [Anonymous], 2002, Natl. Health Stat. Rep
   [Anonymous], COCHRANE DATABASE SY
   Barnes Patricia M, 2008, Natl Health Stat Report, P1
   Bauer BA, 2015, CHIN J INTEGR MED, V21, P569, DOI 10.1007/s11655-015-2101-x
   Berman BM, 2010, NEW ENGL J MED, V363, P454, DOI 10.1056/NEJMct0806114
   Bould MD, 2010, ANAESTHESIA, V65, P799, DOI 10.1111/j.1365-2044.2010.06424.x
   Cho SH, 2010, BJOG-INT J OBSTET GY, V117, P907, DOI 10.1111/j.1471-0528.2010.02570.x
   Chou R, 2007, ANN INTERN MED, V147, P478, DOI 10.7326/0003-4819-147-7-200710020-00006
   De Bellis N., 2009, Bibliometrics and citation analysis: From the science citation index to cybermetrics
   DeShazo JP, 2009, BMC MED INFORM DECIS, V9, DOI 10.1186/1472-6947-9-7
   Dogan RI, 2009, DATABASE-OXFORD, DOI 10.1093/database/bap018
   Durieux V, 2010, RADIOLOGY, V255, P342, DOI 10.1148/radiol.09090626
   Ernst E, 1998, BRIT DENT J, V184, P443, DOI 10.1038/sj.bdj.4809654
   Ernst E, 1998, ARCH INTERN MED, V158, P2235, DOI 10.1001/archinte.158.20.2235
   Falagas ME, 2008, FASEB J, V22, P338, DOI 10.1096/fj.07-9492LSF
   GARFIELD E, 1970, NATURE, V227, P669, DOI 10.1038/227669a0
   Garfield E, 2006, JAMA-J AM MED ASSOC, V295, P90, DOI 10.1001/jama.295.1.90
   Glanville J, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.d1028
   Han JS, 2011, NEUROSCI BIOBEHAV R, V35, P680, DOI 10.1016/j.neubiorev.2010.08.006
   Harris CS, 2015, AM J MED, V128, P331, DOI 10.1016/j.amjmed.2014.10.042
   Highfield ES, 2003, COMPLEMENT THER MED, V11, P177, DOI 10.1016/S0965-2299(03)00069-4
   Huang DM, 2011, CHIN J INTEGR MED, V17, P386, DOI 10.1007/s11655-011-0611-8
   Hunter PR, 2009, LANCET, V373, P630, DOI 10.1016/S0140-6736(09)60397-4
   Kim KH, 2013, ACUPUNCT MED, V31, P228, DOI 10.1136/acupmed-2012-010257
   Langevin HM, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1155/2011/180805
   Lee H, 2004, AM J OBSTET GYNECOL, V191, P1573, DOI 10.1016/j.ajog.2004.05.027
   Lee JH, 2013, CLIN J PAIN, V29, P172, DOI 10.1097/AJP.0b013e31824909f9
   Linde K, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001218.pub2
   Lu ZY, 2011, DATABASE-OXFORD, DOI 10.1093/database/baq036
   Lundeberg Thomas, 2007, Acupunct Med, V25, P100
   Ma Y, 2015, SLEEP MED
   Ma Y, 2016, COMPLEMENT THER MED, V29, pA1, DOI 10.1016/j.ctim.2016.05.003
   Ma Y, 2016, FRONT MED-PRC, V10, P28, DOI 10.1007/s11684-016-0434-2
   Ma Y, 2014, FRONT MED-PRC, V8, P279, DOI 10.1007/s11684-014-0367-6
   Macfarlane GJ, 2012, RHEUMATOLOGY, V51, P2224, DOI 10.1093/rheumatology/kes200
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Manheimer E, 2005, ANN INTERN MED, V142, P651, DOI 10.7326/0003-4819-142-8-200504190-00014
   Manheimer E, 2007, ANN INTERN MED, V146, P868, DOI 10.7326/0003-4819-146-12-200706190-00008
   Mayhew E, 2007, RHEUMATOLOGY, V46, P801, DOI 10.1093/rheumatology/kel406
   McKenzie B., 2011, POPULAR IS ACUPUNCTU
   Michalopoulos A, 2005, CHEST, V128, P3993, DOI 10.1378/chest.128.6.3993
   Paley CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub3
   Quinn N, 2013, PEDIATRICS, V132, P406, DOI 10.1542/peds.2013-0283
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Salehi A, 2015, J EVIDENCE BASED COM
   Schnyer R, 2008, J ALTERN COMPLEM MED, V14, P859, DOI 10.1089/acm.2008.SAR-2
   Shin HC, 2016, LARYNGOSCOPE
   Shuaib W, 2015, AM J CARDIOL, V115, P972, DOI 10.1016/j.amjcard.2015.01.029
   Stener-Victorin Elisabet, 2006, Acupunct Med, V24, P157
   Sun Y, 2008, ANESTH ANALG, V107, P2038, DOI 10.1213/ane.0b013e318187c76a
   Tsai PS, 2016, EUROPEAN J CANC CARE
   Weightman AL, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.d1083
   Wieland LS, 2013, SYST REV, V2, DOI 10.1186/2046-4053-2-51
   Xu H, 2011, CHIN J INTEGR MED, V17, P163, DOI 10.1007/s11655-011-0661-y
   Yang GY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120655
   Young H., 1983, ALA GLOSSARY LIB INF
   Zhao L, 2011, CHIN J INTEGR MED, V17, P580, DOI 10.1007/s11655-011-0709-z
   Zhou KH, 2015, ACUPUNCT MED, V33, P485, DOI 10.1136/acupmed-2015-010911
NR 63
TC 133
Z9 166
U1 5
U2 78
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 14
PY 2016
VL 11
IS 12
AR e0168123
DI 10.1371/journal.pone.0168123
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EI8KC
UT WOS:000392754300056
PM 27973611
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ntowe, KW
   Lee, MS
   Plichta, JK
AF Ntowe, Koumani W.
   Lee, Michael S.
   Plichta, Jennifer K.
TI Clinical genetics in breast cancer
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE breast cancer; genetic testing; genomic testing; hereditary; patient
   outcomes
ID QUALITY-OF-LIFE; HEPATOCELLULAR-CARCINOMA; CHRONIC PAIN; ACUPUNCTURE;
   MANAGEMENT; MECHANISMS
AB As genetic testing becomes increasingly more accessible and more applicable with a broader range of clinical implications, it may also become more challenging for breast cancer providers to remain up-to-date. This review outlines some of the current clinical guidelines and recent literature surrounding germline genetic testing, as well as genomic testing, in the screening, prevention, diagnosis, and treatment of breast cancer, while identifying potential areas of further research.
C1 [Ntowe, Koumani W.; Lee, Michael S.; Plichta, Jennifer K.] Duke Univ, Med Ctr, Dept Surg, Durham, NC USA.
   [Plichta, Jennifer K.] Duke Univ, Duke Canc Inst, Durham, NC USA.
   [Plichta, Jennifer K.] Duke Univ, Med Ctr, Dept Populat Hlth Sci, Durham, NC USA.
   [Plichta, Jennifer K.] DUMC 3513, Duke Dept Surg, Durham, NC 27710 USA.
C3 Duke University; Duke University; Duke University
RP Plichta, JK (corresponding author), DUMC 3513, Duke Dept Surg, Durham, NC 27710 USA.
EM jennifer.plichta@duke.edu
RI Plichta, Jennifer/L-5450-2016
OI Plichta, Jennifer/0000-0002-7411-0558
FU National Institutes of Health [K12AR084231]; National Institutes of
   Health Office of Women's Research Building Interdisciplinary Research
   Careers in Women's Health
FX Dr. Plichta is supported by the National Institutes of Health Office of
   Women's Research Building Interdisciplinary Research Careers in Women's
   Health K12AR084231 (PI: Amundsen).
CR Aggarwal C, 2021, NAT REV CLIN ONCOL, V18, P56, DOI 10.1038/s41571-020-0423-x
   [Anonymous], 2022, SEER stat database: incidence - SEER research data (1975-2019)
   BARGMANN CI, 1986, NATURE, V319, P226, DOI 10.1038/319226a0
   Bartlett JMS, 2019, ANN ONCOL, V30, P1776, DOI 10.1093/annonc/mdz289
   Bedrosian I, 2024, J CLIN ONCOL, V42, DOI 10.1200/JCO.23.02225
   Beitsch PD, 2019, J CLIN ONCOL, V37, P453, DOI 10.1200/JCO.18.01631
   Bevers TB., 2024, NCCN Guidelines: Breast Cancer Risk Reduction (version 1.2024)
   Bevers TB, 2023, J NATL COMPR CANC NE, V21, P900, DOI 10.6004/jnccn.2023.0046
   Bychkovsky B, 2022, LANCET ONCOL, V23, P1124, DOI 10.1016/S1470-2045(22)00378-3
   Cardozo JMN, 2023, J CLIN ONCOL, V41, P1849, DOI 10.1200/JCO.22.01978
   Carter Philip, 2018, Oncotarget, V9, P17589, DOI [10.18632/oncotarget.24564, 10.18632/oncotarget.24564]
   Cintolo-Gonzalez JA, 2017, BREAST CANCER RES TR, V164, P263, DOI 10.1007/s10549-017-4247-z
   Contant CME, 2002, EUR J SURG ONCOL, V28, P627, DOI 10.1053/ejso.2002.1279
   Curigliano G, 2016, ANN ONCOL, V27, P6, DOI 10.1093/annonc/mdv565
   Daly MB, 2024, NCCN clinical practice guidelines in oncology (NCCN Guidelines)-genetic/familial high-risk assessment: breast, ovarian, and pancreatic-version 32024
   Dillon J, 2022, SURG ONCOL CLIN N AM, V31, P109, DOI 10.1016/j.soc.2021.08.004
   Ding W, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000033146
   Espenschied CR, 2017, J CLIN ONCOL, V35, P2568, DOI 10.1200/JCO.2016.71.9260
   Filipits M, 2014, CLIN CANCER RES, V20, P1298, DOI 10.1158/1078-0432.CCR-13-1845
   Giannakeas V, 2018, BREAST CANCER RES TR, V167, P263, DOI 10.1007/s10549-017-4476-1
   Giaquinto AN, 2022, CA-CANCER J CLIN, V72, P524, DOI 10.3322/caac.21754
   Gradishar WJ, 2024, Breast cancer, version 1.2024, NCCN clinical practice guidelines in oncology
   Green MF, 2023, ONCOLOGIST, V28, P33, DOI 10.1093/oncolo/oyac164
   Green MF, 2021, JCO PRECIS ONCOL, V5, P1493, DOI 10.1200/PO.21.00030
   Guindalini RS, 2019, CLIN CANCER RES, V25, P1786, DOI 10.1158/1078-0432.CCR-18-0200
   HALL JM, 1990, SCIENCE, V250, P1684, DOI 10.1126/science.2270482
   Han HS, 2022, ANN ONCOL, V33, P299, DOI 10.1016/j.annonc.2021.11.018
   Heemskerk-Gerritsen BAM, 2019, BREAST CANCER RES TR, V177, P723, DOI 10.1007/s10549-019-05345-2
   Hu CL, 2021, NEW ENGL J MED, V384, P440, DOI 10.1056/NEJMoa2005936
   Kalinsky K, 2021, NEW ENGL J MED, V385, P2336, DOI 10.1056/NEJMoa2108873
   Kratz Jeremy, 2018, Am Soc Clin Oncol Educ Book, V38, P56, DOI [10.1200/edbk_200731, 10.1200/EDBK_200731]
   Kuchenbaecker KB, 2017, JAMA-J AM MED ASSOC, V317, P2402, DOI 10.1001/jama.2017.7112
   Lapkus M, 2023, ANN SURG ONCOL, V30, P6108, DOI 10.1245/s10434-023-13895-5
   Leighl NB, 2019, CLIN CANCER RES, V25, P4691, DOI 10.1158/1078-0432.CCR-19-0624
   Li X, 2016, CLIN CANCER RES, V22, P3971, DOI 10.1158/1078-0432.CCR-15-1465
   Litton JK, 2020, ANN ONCOL, V31, P1526, DOI 10.1016/j.annonc.2020.08.2098
   Manahan ER, 2019, ANN SURG ONCOL, V26, P3025, DOI 10.1245/s10434-019-07549-8
   Mariotto AB, 2017, CANCER EPIDEM BIOMAR, V26, P809, DOI [10.1158/1055-9965.EPI-16-0889, 10.1158/1055-9965.epi-16-0889]
   Matsubara J, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.23336
   Mavaddat N, 2019, AM J HUM GENET, V104, P21, DOI 10.1016/j.ajhg.2018.11.002
   Naranjo ID, 2022, AM J ROENTGENOL, V218, P810, DOI 10.2214/AJR.21.27022
   NOWELL PC, 1960, JNCI-J NATL CANCER I, V25, P85
   Pascual J, 2021, CANCER RES, V81
   Patsouris A, 2021, EUR J CANCER, V159, P283, DOI 10.1016/j.ejca.2021.09.028
   Piccart M, 2021, LANCET ONCOL, V22, P476, DOI 10.1016/S1470-2045(21)00007-3
   Plichta JK, 2019, ANN SURG ONCOL, V26, P2184, DOI 10.1245/s10434-019-07341-8
   Popejoy AB, 2016, NATURE, V538, P161, DOI 10.1038/538161a
   Pruthi S, 2015, ANN SURG ONCOL, V22, P3230, DOI 10.1245/s10434-015-4715-9
   Pu MY, 2020, BREAST CANCER RES TR, V179, P197, DOI 10.1007/s10549-019-05446-y
   Rakovitch E, 2021, JNCI-J NATL CANCER I, V113, P572, DOI 10.1093/jnci/djaa179
   Rakovitch E, 2015, BREAST CANCER RES TR, V152, P389, DOI 10.1007/s10549-015-3464-6
   Rebbeck TR, 2004, J CLIN ONCOL, V22, P1055, DOI 10.1200/JCO.2004.04.188
   Sakorafas GH, 2010, EUR J CANCER CARE, V19, P6, DOI 10.1111/j.1365-2354.2008.01060.x
   Sestak I, 2019, BREAST CANCER RES TR, V176, P377, DOI 10.1007/s10549-019-05226-8
   Shelton C, 2024, ANN SURG ONCOL, V31, P325, DOI 10.1245/s10434-023-14394-3
   Shiovitz S, 2015, ANN ONCOL, V26, P1291, DOI 10.1093/annonc/mdv022
   Siegel RL, 2022, CA-CANCER J CLIN, V72, P7, DOI 10.3322/caac.21708
   Sogani J, 2021, CLIN IMAG, V69, P269, DOI 10.1016/j.clinimag.2020.09.003
   Sparano JA, 2018, NEW ENGL J MED, V379, P111, DOI 10.1056/NEJMoa1804710
   Sparano JA, 2015, NEW ENGL J MED, V373, P2005, DOI 10.1056/NEJMoa1510764
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Taskindoust M, 2021, ANN SURG ONCOL, V28, P7441, DOI 10.1245/s10434-021-10227-3
   Turner NC, 2021, CLIN CANCER RES, V27, P5482, DOI 10.1158/1078-0432.CCR-21-0310
   Tutt ANJ, 2021, NEW ENGL J MED, V384, P2394, DOI 10.1056/NEJMoa2105215
   van Sprundel TC, 2005, BRIT J CANCER, V93, P287, DOI 10.1038/sj.bjc.6602703
   Wickland DP, 2022, JNCI-J NATL CANCER I, V114, P1192, DOI 10.1093/jnci/djac054
   WOOSTER R, 1994, SCIENCE, V265, P2088, DOI 10.1126/science.8091231
   Zarbiv Y, 2022, ONCOL THER, V10, P441, DOI 10.1007/s40487-022-00202-7
   Zardavas D, 2015, NAT REV CLIN ONCOL, V12, P381, DOI 10.1038/nrclinonc.2015.73
NR 69
TC 5
Z9 5
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4790
EI 1096-9098
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD JUL
PY 2024
VL 130
IS 1
BP 16
EP 22
DI 10.1002/jso.27630
EA APR 2024
PG 7
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA ZD2T1
UT WOS:001194139400001
PM 38557982
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Chen, QY
   Ma, HM
   Yi, L
AF Chen, Qiuyu
   Ma, Hongmei
   Yi, Liu
TI Acupoint Application Combined with Acupressure as an Adjunctive Therapy
   for Chemotherapy-induced Nausea and Vomiting
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID PREVENT DELAYED EMESIS; REEVALUATION; ANTAGONISTS
AB Chemotherapy-induced nausea and vomiting (CINV) refers to the nausea and vomiting experienced by patients after the application of chemotherapy drugs, significantly affecting their quality of life and physical recovery, as well as increasing the pain of the patients. Basic medicine primarily focuses on acid suppression, gastric protection, and vomiting suppression, but there are still many patients with nausea and vomiting symptoms that cannot be alleviated. Traditional Chinese medicine (TCM) can effectively alleviate nausea and vomiting through acupoint stimulation and pressure, while also offering advantages such as simplicity, affordability, and fewer side effects. The aim of this article is to introduce the method of using acupoint application combined with acupressure as an adjunctive therapy for CINV, using the Multinational Association of Supportive Care in Cancer (MASCC) Antiemesis Tool (MAT) tablet scale as a questionnaire. The article details aspects such as acupoint selection, production, and the use of acupoint application, massage techniques, and operating procedures, all with the goal of ensuring the safety and efficacy of acupoint application combined with acupressure as an adjuvant therapy, thereby improving patients' clinical symptoms and quality of life.
C1 [Chen, Qiuyu; Yi, Liu] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.
   [Ma, Hongmei] Chengdu First Peoples Hosp, Oncol Dept, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Chen, QY (corresponding author), Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.
EM chenqiuyu@stu.cdutcm.edu.cn
FU The 'Scholar of XingLin' Discipline Talent Research Enhancement Program
   of Chengdu University of Traditional Chinese Medicine [XKTD2022014]
FX We acknowledge the financial support from the 'Scholar of XingLin'
   Discipline Talent Research Enhancement Program of Chengdu University of
   Traditional Chinese Medicine (Grant No. XKTD2022014) .
CR Ballatori E, 2007, SUPPORT CARE CANCER, V15, P179, DOI 10.1007/s00520-006-0109-7
   Chen Xiao-li, 2016, J CLIN ACUPUNCT MOXI, V32, P80, DOI DOI 10.19917/J.CNKI.1005-0779.2016.07.028
   CHIEN YW, 1984, J PHARM SCI, V73, P283, DOI 10.1002/jps.2600730241
   Chinese Society of Integrative Anesthesiology, 2019, J Clin Anesthesiol., V35, P596
   Darmani NA, 2009, CHEM REV, V109, P3158, DOI 10.1021/cr900117p
   Du J., 2007, Chin J Comp Med., V04, P233
   Feyer P, 2011, ANN ONCOL, V22, P30, DOI 10.1093/annonc/mdq600
   Gasco V, 2010, ENDOCR DEV, V17, P86, DOI 10.1159/000262531
   Geling O, 2005, J CLIN ONCOL, V23, P1289, DOI 10.1200/JCO.2005.04.022
   Hesketh PJ, 2008, NEW ENGL J MED, V358, P2482, DOI 10.1056/NEJMra0706547
   Jordan K, 2007, SUPPORT CARE CANCER, V15, P1023, DOI 10.1007/s00520-006-0186-7
   Kris MG, 1997, J NATL CANCER I, V89, P817, DOI 10.1093/jnci/89.11.817
   Li X. D., 2020, Shanghai Nursing, V20, P12
   Liu W. J., 2017, Clinical study on prevention and treatment of nausea and vomiting caused by chemotherapy of advanced gastrointestinal tumor by acupoint application
   Marx W, 2017, EUR J INTEGR MED, V10, P19, DOI 10.1016/j.eujim.2017.02.001
   Miao W. H., 2014, Shanxi Journal of Traditional Chinese Medicine, V30, P33
   Molassiotis A, 2007, J PAIN SYMPTOM MANAG, V34, P148, DOI 10.1016/j.jpainsymman.2006.10.018
   Mustian Karen M, 2011, US Oncol Hematol, V7, P91
   Osoba D, 1996, ONCOLOGY-BASEL, V53, P92, DOI 10.1159/000227647
   Roila F, 2010, ANN ONCOL, V21, pv232, DOI 10.1093/annonc/mdq194
   Sheng X., 2012, Yunnan Journal of Traditional Chinese Medicine and Materia Medica, V33, P48
   Singh P, 2016, THER ADV GASTROENTER, V9, P98, DOI 10.1177/1756283X15618131
   Wang L. N., 2013, Journal of Shanxi University of TCM., V36, P27
   [郑亚萍 ZHENG Ya-ping], 2010, [中华护理杂志, Chinese Journal of Nursing], V45, P118
NR 24
TC 1
Z9 1
U1 5
U2 20
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD JUN
PY 2024
IS 208
AR e66865
DI 10.3791/66865
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA YE3Q1
UT WOS:001266773900003
PM 38975748
DA 2026-01-16
ER

PT J
AU Zhao, QN
   Zhang, JF
   Shi, WR
   Qian, XY
   An, JX
AF Zhao, Qiannan
   Zhang, Jianfeng
   Shi, Wanrui
   Qian, Xiaoyan
   An, Jianxiong
TI Different mechanisms of electroacupuncture and pregabalin in neuropathic
   pain-induced ultrastructure damage in a rat model of brachial plexus
   neuralgia
SO NEUROLOGICAL RESEARCH
LA English
DT Article
DE Neuropathic pain; structural changes; electroacupuncture; pregabalin;
   morphology
ID MIRROR-IMAGE PAIN; INJURY; HYPERALGESIA; PREVALENCE; GUIDELINES;
   ALLODYNIA; NERVE
AB Objectives: Brachial plexus neuralgia (BPN) can result from injury, trauma, or cancer, and it significantly impacts the patient's quality of life. This study investigated electroacupuncture (EA) vs. pregabalin on the structural changes in the peripheral nervous system (PNS) and central nervous system (CNS) in rats with BPN. Methods: Male Sprague-Dawley rats were randomized to the sham-operated (Con), BPN (using cobra venom), BPN+EA (EA), and BPN+pregabalin (PGB) groups (n = 8/group). EA or pregabalin was given from postoperative day (POD)14 to POD35. Structural alterations were determined by transmission electron microscopy in the primary sensory cortex, forelimb region (S1FL), anterior cingulate cortex (ACC), hippocampus, thalamus, cervical, thoracic, and lumbar spinal cords on POD40, and in the bilateral brachial plexus and dorsal root ganglions (DRG) at the cervical, thoracic and lumbar levels. Results: Compared with the CON group, BPN rats exhibited significant changes in mechanical withdrawal threshold (MWT) (p < 0.05). The MWT showed a significant increase compared with the BNP group after EA or pregabalin (p < 0.05), but the long-term analgesic effects of EA appeared superior to pregabalin (p < 0.05). Furthermore, EA alleviated myelin sheath damage at the spinal cord levels. Damage, including demyelination, was limited to the ipsilateral DRG at the corresponding segment and bilateral CNS. Conclusion: Neuropathic pain-induced damage is limited to the ipsilateral DRG at corresponding segment and bilateral CNS pain centers. EA and pregabalin each partially attenuate neuropathic pain and alleviate neuronal damage in BPN, but EA has a longer-term analgesic effect.
C1 [Zhao, Qiannan; Qian, Xiaoyan; An, Jianxiong] China Med Univ, Aviat Gen Hosp, Chinese Acad Sci, Dept Anesthesiol Pain & Sleep Med, Beijing, Peoples R China.
   [Zhao, Qiannan; Qian, Xiaoyan; An, Jianxiong] Beijing Inst Translat Med, Beijing, Peoples R China.
   [Zhang, Jianfeng] Peking Univ Peoples Hosp, Dept Anesthesiol, Beijing, Peoples R China.
   [Shi, Wanrui] Peking Univ Third Hosp, Dept Ultrasound, Beijing, Peoples R China.
   [An, Jianxiong] Shandong Second Med Univ, Affiliated Hosp, Sch Anesthesiol, Dept Pain Med, Weifang, Shandong, Peoples R China.
C3 Chinese Academy of Sciences; China Medical University; Peking
   University; Shandong Second Medical University
RP An, JX (corresponding author), China Med Univ, Aviat Gen Hosp, Dept Anesthesiol Pain & Sleep Med, Beiyuan Rd 3, Beijing 100012, Peoples R China.; An, JX (corresponding author), Chinese Acad Sci, Beijing Inst Translat Med, Beiyuan Rd 3, Beijing 100012, Peoples R China.
EM anjianxiong@yeah.net
RI Zhao, Qiannan/GRS-1686-2022
FU National Natural Science Foundation of China [82405553]; National Key
   R&D Program of China [2024YFC2510200]
FX This work was funded by the National Natural Science Foundation of China
   (82405553) and National Key R&D Program of China (2024YFC2510200).
CR Attia GM, 2019, FOLIA NEUROPATHOL, V57, P146, DOI 10.5114/fn.2019.84423
   Bidve P, 2020, J DRUG TARGET, V28, P11, DOI 10.1080/1061186X.2019.1587444
   Burjek NE, 2023, ANESTHES PERIOP SCI, V1, DOI [10.1007/s44254-023-00024-4, 10.1007/s44254-023-00024-4]
   Cao Y, 2013, J PAIN, V14, P193, DOI 10.1016/j.jpain.2012.11.005
   Lovaglio AC, 2019, NEUROL INDIA, V67, pS32, DOI 10.4103/0028-3886.250699
   CHAPLAN SR, 1994, J NEUROSCI METH, V53, P55, DOI 10.1016/0165-0270(94)90144-9
   Chen Feng, 2009, Zhen Ci Yan Jiu, V34, P363
   Chen RW, 2017, J PAIN RES, V10, P1887, DOI 10.2147/JPR.S140840
   Ciaramitaro P, 2017, PAIN MED, V18, P2428, DOI 10.1093/pm/pnw360
   Colloca L, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.2
   Davis G, 2016, HAND CLIN, V32, P257, DOI 10.1016/j.hcl.2015.12.011
   Derry S, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007076.pub3
   du Sert NP, 2020, BRIT J PHARMACOL, V177, P3617, DOI [10.1111/bph.15193, 10.1186/s12917-020-02451-y, 10.1136/bmjos-2020-100115]
   Field MJ, 1999, PAIN, V83, P303, DOI 10.1016/S0304-3959(99)00111-6
   Finnerup NB, 2021, PHYSIOL REV, V101, P259, DOI 10.1152/physrev.00045.2019
   Fiore NT, 2024, BRAIN BEHAV IMMUN, V122, P287, DOI 10.1016/j.bbi.2024.07.043
   Gadepalli A, 2024, NEUROTHERAPEUTICS, V21, DOI 10.1016/j.neurot.2023.10.012
   Gao L, 2021, J PAIN RES, V14, P2893, DOI 10.2147/JPR.S322964
   Gilcrease-Garcia BM, 2020, RADIOGRAPHICS, V40, P1686, DOI 10.1148/rg.2020200012
   Ha KY, 2011, J KOREAN MED SCI, V26, P404, DOI 10.3346/jkms.2011.26.3.404
   Hong ES, 2021, J SPINAL CORD MED, V44, P364, DOI [10.30528/jolss.2019.9.3.001, 10.1080/10790268.2019.1665612, 10.30528/jolss.2019.9.3.001]
   Huang DY, 2010, NEUROSCI BIOBEHAV R, V34, P528, DOI 10.1016/j.neubiorev.2009.10.011
   Hui L., 2016, PAIN PHYSICIAN, V19
   Jancalek R, 2011, ANN NEUROSCI, V18, P123, DOI [10.5214/ans.0972.7531.11183010, 10.5214/ans.0972-7531.11183010]
   Jia LL, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/9187406
   Karsy M, 2019, WORLD NEUROSURG, V123, pE488, DOI 10.1016/j.wneu.2018.11.192
   Khandia R, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8070674
   Koltzenburg M, 1999, TRENDS NEUROSCI, V22, P122, DOI 10.1016/S0166-2236(98)01302-2
   Kumar N, 2010, J NEUROCHEM, V113, P552, DOI 10.1111/j.1471-4159.2010.06625.x
   Lao LX, 2004, BRAIN RES, V1020, P18, DOI 10.1016/j.brainres.2004.01.092
   Lau WK, 2010, NEUROSCIENCE, V170, P655, DOI 10.1016/j.neuroscience.2010.07.031
   Le W, 2015, NEUROSCI LETT, V589, P52, DOI 10.1016/j.neulet.2015.01.033
   Liu CC, 2015, PAIN MED, V16, P1680, DOI 10.1111/pme.12722
   Liu H, 2016, PAIN PHYSICIAN, V19, pE435, DOI 10.36076/ppj/2019.19.e435
   Liu JY, 2024, BRAIN RES BULL, V216, DOI 10.1016/j.brainresbull.2024.111036
   Makabe K, 2024, ARTHRITIS RES THER, V26, DOI 10.1186/s13075-024-03354-1
   Hoang NS, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-141
   Nozaki C, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28507-6
   Oaklander AL, 2008, J PAIN, V9, pS10, DOI 10.1016/j.jpain.2007.10.003
   Onakpoya IJ, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-023600
   Qi DB, 2016, LIFE SCI, V160, P64, DOI 10.1016/j.lfs.2016.06.025
   Ribeiro H, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10061255
   Santana MVB, 2016, ARQ NEURO-PSIQUIAT, V74, P895, DOI 10.1590/0004-282X20160149
   Sharma K, 2018, NEUROSCI LETT, V674, P162, DOI 10.1016/j.neulet.2018.03.030
   Tiwari V, 2020, PAIN, V161, P842, DOI 10.1097/j.pain.0000000000001768
   Tiwari V, 2014, NEUROSCI BIOBEHAV R, V45, P19, DOI 10.1016/j.neubiorev.2014.05.002
   Torres FD, 2023, FRONT NEUROSCI-SWITZ, V17, DOI 10.3389/fnins.2023.1221777
   Uniyal A, 2023, TRENDS PHARMACOL SCI, V44, P1009, DOI 10.1016/j.tips.2023.10.003
   Wang L, 2022, J NEUROINFLAMM, V19, DOI 10.1186/s12974-022-02628-2
   Wang M, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/7536234
   Wu MF, 2015, NEURAL REGEN RES, V10, P1628, DOI 10.4103/1673-5374.167762
   Wu Y, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-03371-0
   Xin YY, 2022, ACUPUNCT MED, V40, P474, DOI 10.1177/09645284221076515
   Xu J, 2022, INVEST OPHTH VIS SCI, V63, DOI 10.1167/iovs.63.12.7
   Yang S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20133130
   Yoon JS, 2011, NEUROBIOL DIS, V41, P624, DOI 10.1016/j.nbd.2010.11.011
   Zhang RX, 2014, ANESTHESIOLOGY, V120, P482, DOI 10.1097/ALN.0000000000000101
   Zhang XH, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.657507
   Zhao XL, 2013, NAT NEUROSCI, V16, P1024, DOI 10.1038/nn.3438
   Zhou MM, 2023, BIOMED PHARMACOTHER, V161, DOI 10.1016/j.biopha.2023.114516
   Zhu JH, 2007, AM J PATHOL, V170, P75, DOI 10.2353/ajpath.2007.060524
   ZIMMERMANN M, 1983, PAIN, V16, P109, DOI 10.1016/0304-3959(83)90201-4
   Zou J, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/6637693
NR 63
TC 0
Z9 0
U1 4
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0161-6412
EI 1743-1328
J9 NEUROL RES
JI Neurol. Res.
PD DEC 2
PY 2025
VL 47
IS 12
BP 1139
EP 1152
DI 10.1080/01616412.2025.2515195
EA JUN 2025
PG 14
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA K6088
UT WOS:001506320200001
PM 40494390
DA 2026-01-16
ER

PT J
AU Hou, WZ
   Pei, LX
   Song, YF
   Wu, J
   Geng, H
   Chen, L
   Wang, YH
   Hu, Y
   Zhou, JY
   Sun, JH
AF Hou, Wenzhen
   Pei, Lixia
   Song, Yafang
   Wu, Jian
   Geng, Hao
   Chen, Lu
   Wang, Yuhang
   Hu, Yao
   Zhou, Jinyong
   Sun, Jianhua
TI Acupuncture therapy for breast cancer-related lymphedema: A systematic
   review and meta-analysis
SO JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
LA English
DT Review
DE acupuncture therapy; breast cancer-related lymphedema; meta-analysis
ID QUALITY-OF-LIFE
AB This study aimed to conduct a comprehensive analysis of clinical studies on acupuncture treatment for breast cancer-related lymphedema (BCRL), so as to explore the efficacy and safety of acupuncture treatment and provide evidence for the clinical decision-making. Public databases, mainly including China Academic Journals Full-text Database, Database of Chinese Sci-Tech Journal, Wanfang, PubMed, Embase and the Cochrane Library, from the establishment of databases to December 2018 were searched for randomized controlled trials (RCT) of acupuncture for BCRL. Clinical RCT on the treatment of BCRL with acupuncture combined with drugs or functional exercise were enrolled for the analysis. Bias risk and quality were assessed by two investigators according to the Cochrane Handbook 5.1.0 standard, and the Revman 5.3 software was used for meta-analysis. A total of 13 studies were enrolled, comprising 747 patients (377 in the treatment group and 370 in the control group). The results of meta-analysis showed that acupuncture intervention could improve the total effective rate for the treatment of BCRL (odds ratio = 4.62; 95% confidence interval 2.61-8.17). Recent studies suggest that acupuncture therapy can alleviate the upper limb swelling and improve the subjective pain and discomfort in patients with BCRL, regardless of the control intervention used. However, the number of high-quality RCT is low. Moreover, most of the studies adopted inconsistent efficacy indicators. Hence, additional blinded, large-sample, randomized, well-controlled studies with objective and uniform efficacy indicators are needed, especially in China, to confirm the findings.
C1 [Hou, Wenzhen; Pei, Lixia; Geng, Hao; Chen, Lu; Sun, Jianhua] Nanjing Univ Chinese Med, Affiliated Hosp, Dept Acupuncture, Nanjing, Jiangsu, Peoples R China.
   [Wu, Jian; Zhou, Jinyong] Nanjing Univ Chinese Med, Affiliated Hosp, Dept Cent Lab, Nanjing, Jiangsu, Peoples R China.
   [Song, Yafang; Wang, Yuhang] Nanjing Univ Chinese Med, Dept Acupuncture & Manipulat, Nanjing, Jiangsu, Peoples R China.
   [Hu, Yao] WUXI Higher Hlth Vocat Technol Sch, Dept TCM, Wuxi, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine
RP Sun, JH (corresponding author), Nanjing Univ Chinese Med, Affiliated Hosp, Dept Acupuncture, Nanjing, Jiangsu, Peoples R China.; Zhou, JY (corresponding author), Nanjing Univ Chinese Med, Affiliated Hosp, Dept Cent Lab, Nanjing, Jiangsu, Peoples R China.
EM jinyongzhou@126.com; 377201634@qq.com
FU National Natural Science Foundation of China [81804193]; Youth Natural
   foundation of the Science and Technology Department of Jiangsu Province
   [BK20161083]; Leading Talents Project from Jiangsu Provincial
   Administration of TCM [SLJ0206]; peak talent project of Jiangsu Province
   Hospital of TCM [y2018rc05]
FX This work was supported by the Young Scientists Fund of the National
   Natural Science Foundation of China (No. 81804193), the Youth Natural
   foundation of the Science and Technology Department of Jiangsu Province
   (No. BK20161083), The Leading Talents Project from Jiangsu Provincial
   Administration of TCM (SLJ0206) and the peak talent project of Jiangsu
   Province Hospital of TCM (y2018rc05).
CR [Anonymous], 2017, Chinese Journal of Woman and Child Health Research
   [Anonymous], CHINA MED HER
   [Anonymous], 2012, Chin J Clin Res
   [Anonymous], EFFICACY WARM MOXIBU
   [Anonymous], CLIN MED ENG
   [Anonymous], J ZHEJIANG U TRADIT
   Bao T, 2018, BREAST CANCER RES TR, V170, P77, DOI 10.1007/s10549-018-4743-9
   CRUK, 2017, BREAST CANC INC
   DiSipio T, 2013, LANCET ONCOL, V14, P500, DOI 10.1016/S1470-2045(13)70076-7
   Feng L., 2018, Modern Journal of Integrated Traditional Chin and Western Med, V27, P1870
   Jiang X, 2008, J NURS SCI, V23, P37
   Jiao HF, 2017, NEI MONGOL J TRADITI, V36, P130
   Lasinski BB, 2012, PM&R, V4, P580, DOI 10.1016/j.pmrj.2012.05.003
   Lee TS, 2008, BREAST CANCER RES TR, V110, P19, DOI 10.1007/s10549-007-9710-9
   段碧芳, 2007, [中医杂志, Journal of Traditional Chinese Medicine], V48, P314
   Petrek JA, 2001, CANCER, V92, P1368, DOI 10.1002/1097-0142(20010915)92:6<1368::AID-CNCR1459>3.0.CO;2-9
   Ridner SH, 2005, SUPPORT CARE CANCER, V13, P904, DOI 10.1007/s00520-005-0810-y
   Smith CA, 2014, ACUPUNCT MED, V32, P387, DOI 10.1136/acupmed-2014-010593
   Taghian NR, 2014, CRIT REV ONCOL HEMAT, V92, P227, DOI 10.1016/j.critrevonc.2014.06.004
   Wu C., 2018, Chin Med J Metall Ind, V35, P324
   Yao C, 2016, CURR ONCOL, V23, pE27, DOI 10.3747/co.23.2788
   Zhang XY, 2019, ACUPUNCT MED, V37, P16, DOI 10.1136/acupmed-2018-011668
NR 22
TC 19
Z9 23
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1341-8076
EI 1447-0756
J9 J OBSTET GYNAECOL RE
JI J. Obstet. Gynaecol. Res.
PD DEC
PY 2019
VL 45
IS 12
BP 2307
EP 2317
DI 10.1111/jog.14122
EA OCT 2019
PG 11
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA JR4UX
UT WOS:000489867000001
PM 31608558
DA 2026-01-16
ER

PT J
AU Chin, Y
   Pan, XF
   Wang, B
   Zhao, MD
   Ai, YK
   Zhao, TY
AF Chin, Yenlie
   Pan, Xingfang
   Wang, Bin
   Zhao, Meidan
   Ai, Yanke
   Zhao, Tianyi
TI Network meta-analysis for comparative effectiveness and safety of
   acupuncture on chemotherapy-induced peripheral neuropathy: A protocol
   and Bayesian network meta-analysis
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Acupuncture; Chemotherapy induced-peripheral neuropathy; Systematic
   review; Bayesian network meta-analysis
ID BREAST-CANCER; SYSTEMATIC REVIEWS; MANAGEMENT; PAIN; PREVENTION;
   SURVIVORS; QUALITY; TRIAL
AB Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) reduces the quality-of-life, affects recovery, and increases the risk of chemotherapeutic failure. Acupuncture may be effective in treating CIPN. This study aims to evaluate the effectiveness and safety of different types of acupuncture through a systematic review and network meta-analysis. The objective of this study is to indicate the relative efficacy and safety among various types of acupuncture for CIPN via a network meta-analysis (NMA) and systematic review.Methods: Six electronic databases, namely Excerpta Medica Database [Embase], PubMed, Cochrane Central Register of Controlled Trials, Web of Science, China National Knowledge Infrastructure, and Wanfang Med Online, will be searched for publications from 2010 to 2022. All relevant randomized controlled trials (RCTs) meeting the eligibility criteria will be included. The primary outcome is the brief pain inventory score, including brief pain inventory-short form, and autonomic nerve symptoms. Secondary outcomes include the quality-of-life assessment of anxiety, depression, and sleep of people with CIPN and adverse events. Reviewers will conduct processes for study selection, data extraction, and risk-of-bias assessment. Stata version 15.0 will be used to perform pairwise and Bayesian network NMA. Each included study will be assessed for bias using the revised Cochrane risk-of-bias tool for randomized trials. A funnel plot will show publication bias.Discussion: We will assess the benefits and drawbacks of various acupuncture-related therapies, rank the efficacy of various acupuncture-related therapies for treating CIPN, and describe the best approaches or combinations of acupuncture interventions based on available data.Conclusion: This study will contribute to data on the safety and efficacy of acupuncture-related therapies for treating CIPN and will help clinicians better select acupuncture treatment types to deal with the different clinical problems of CIPN.Ethics and dissemination: There is no need for ethics approval for this systematic review and meta-analysis. The results will be published in a peer-reviewed journal.PROSPERO registration number: CRD42020198388
C1 [Chin, Yenlie; Wang, Bin] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin 300181, Peoples R China.
   [Pan, Xingfang; Zhao, Meidan; Zhao, Tianyi] Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, Tianjin 301617, Peoples R China.
   [Ai, Yanke] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China.
   [Zhao, Tianyi] Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Tianjin 301617, Peoples R China.
C3 Tianjin Medical University; Tianjin University of Traditional Chinese
   Medicine; China Academy of Chinese Medical Sciences; Institute of Basic
   Research In Clinical Medicine, CACMS; Tianjin University of Traditional
   Chinese Medicine
RP Zhao, TY (corresponding author), Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, Tianjin 301617, Peoples R China.; Ai, YK (corresponding author), China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China.; Zhao, TY (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Tianjin 301617, Peoples R China.
EM aiyanke@163.com; zhaotianyi89@126.com
RI ; Zhao, Meidan/HKM-5943-2023
OI Zhao, Tianyi/0000-0002-8705-4647; 
FU Scientific and technological innovation project of China Academy of
   Chinese Medical Sciences [CI2021B003]; Certification Center for Chinese
   Medicine Practitioners of State Administration of Traditional Chinese
   Medicine [TB2022003]
FX & nbsp;This research is funded by Scientific and technological
   innovation project of China Academy of Chinese Medical Sciences, No:
   CI2021B003, and Certification Center for Chinese Medicine Practitioners
   of State Administration of Traditional Chinese Medicine, No: TB2022003.
CR Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Baviera AF, 2019, REV LAT-AM ENFERM, V27, DOI 10.1590/1518-8345.2959.3126
   Ben-Arye E, 2022, CANCER-AM CANCER SOC, V128, P3641, DOI 10.1002/cncr.34422
   Bhatnagar B, 2014, SPRINGERPLUS, V3, DOI 10.1186/2193-1801-3-366
   Chiavaroli L, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-019438
   Chien TJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419886662
   Dias S., 2018, NETWORK META ANAL DE
   Feng R, 2015, DIAGN PATHOL, V10, DOI 10.1186/s13000-015-0382-1
   Fino PC, 2019, GAIT POSTURE, V69, P136, DOI 10.1016/j.gaitpost.2019.01.025
   Franconi G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/516916
   Gelman A., 1992, STAT SCI, V7, P457, DOI [DOI 10.1214/SS/1177011136, 10.1214/ss/1177011136]
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Hausheer FH, 2006, SEMIN ONCOL, V33, P15, DOI 10.1053/j.seminoncol.2005.12.010
   Ho RST, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09856-0
   Hutton B, 2015, ANN INTERN MED, V162, P777, DOI 10.7326/M14-2385
   Hwang MS, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019837
   Iravani S, 2020, PAIN RES MANAG, V2020, DOI 10.1155/2020/2504674
   Jin YX, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8875433
   Kachrani R, 2020, J PAIN PALLIAT CARE, V34, P141, DOI 10.1080/15360288.2020.1734144
   Li QY, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.764473
   Li XX, 2017, PAIN PHYSICIAN, V20, pE882
   Loprinzi CL, 2000, LANCET, V356, P2059, DOI 10.1016/S0140-6736(00)03403-6
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
   Molassiotis A, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419836501
   Pachman DR, 2011, CLIN PHARMACOL THER, V90, P377, DOI 10.1038/clpt.2011.115
   Pachman DR, 2014, SUPPORT CARE CANCER, V22, P2281, DOI 10.1007/s00520-014-2289-x
   Pike Crystal T, 2012, Chemother Res Pract, V2012, P913848, DOI 10.1155/2012/913848
   Postma TJ, 2000, ANN ONCOL, V11, P509, DOI 10.1023/A:1008345613594
   Rosenberger KJ, 2021, BMC MED RES METHODOL, V21, DOI 10.1186/s12874-021-01397-5
   Salanti G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099682
   Schünemann HJ, 2008, BMJ-BRIT MED J, V336, P1106, DOI 10.1136/bmj.39500.677199.AE
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Tender T, 2021, MED ONCOL, V38, DOI 10.1007/s12032-021-01496-9
   Tomlinson A, 2019, EVID-BASED MENT HEAL, V22, P61, DOI 10.1136/ebmental-2019-300087
   Veroniki AA, 2013, INT J EPIDEMIOL, V42, P332, DOI 10.1093/ije/dys222
   Wan RH, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.829409
   Winters-Stone KM, 2016, J CLIN ONCOL, V34, DOI 10.1200/jco.2016.34.3_suppl.130
   Wong R, 2016, INTEGR CANCER THER, V15, P153, DOI 10.1177/1534735415627926
   Wu XM, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-049778
   Xu ZH, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.963358
   Zanville NR, 2016, SUPPORT CARE CANCER, V24, P4779, DOI 10.1007/s00520-016-3329-5
NR 43
TC 1
Z9 1
U1 4
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD AUG
PY 2023
VL 61
AR 102261
DI 10.1016/j.eujim.2023.102261
EA JUN 2023
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA N1OZ6
UT WOS:001034803000001
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Xie, SX
   Bowman, MA
AF Mao, Jun J.
   Xie, Sharon X.
   Bowman, Marjorie A.
TI UNCOVERING THE EXPECTANCY EFFECT: THE VALIDATION OF THE ACUPUNCTURE
   EXPECTANCY SCALE
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
ID INHIBITOR-RELATED ARTHRALGIA; LOW-BACK-PAIN; PATIENT EXPECTATIONS;
   CONTROLLED-TRIAL; OSTEOARTHRITIS; PLACEBO; KNEE; DISSOCIATION;
   METAANALYSIS; CARE
AB Purpose circle Research suggests that expectancy may modulate the response to medical interventions, including acupuncture. However, the paucity of validated tools to measure expectancy limits rigorous evaluation. We sought to validate a previously developed Acupuncture Expectancy Scale (AES) as an instrument to measure patients' expected responses to acupuncture.
   Purpose circle Participants were patients with stage I to III cancers seen in outpatient medical and radiation oncology clinics. They were drawn from three study cohorts that included 404 participants. We examined the reliability, validity, and responsiveness of the AES.
   Results circle The scores on the AES had internal consistency (Cronbach's alpha coefficient) of 0.95 and test-retest reliability of 0.62 over 4 weeks without acupuncture treatment. Those who had previously used acupuncture had higher AES scores compared to those who were acupuncture nave (12.4 vs 9.5, P = .002). AES scores were higher in those who reported willingness to participate in an acupuncture trial compared to those who did not want to participate in an acupuncture trial (11.5 vs 8.1, P < .001). Patients who enrolled in a pilot trial of acupuncture had higher AES scores than the general outpatient population (13.0 vs 9.8, P = .02), and expectancy increased during the course of acupuncture treatment (13.0 to 16.5, P < .017).
   Conclusion circle The AES is reliable and valid, and scores appear to increase during or after prior therapy. Incorporation of AES in clinical trials and outcome studies can evaluate the role of expectancy on acupuncture outcomes.
C1 [Mao, Jun J.; Bowman, Marjorie A.] Univ Penn, Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA.
   [Mao, Jun J.; Xie, Sharon X.] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania
RP Mao, JJ (corresponding author), Univ Penn, Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA.
EM maoj@uphs.upenn.edu
RI Mao, Jun/F-5009-2012; bowman, marjorie/F-7235-2013; Xie,
   Sharon/JCO-7144-2023
OI bowman, marjorie/0000-0002-1945-9212; 
FU National Institutes of Health/National Center for Complementary and
   Alternative Medicine [K23 AT004112]; American Cancer Society
   [IRG-78-002-30]; Pennsylvania Department of Aging
FX Dr Mao is supported by National Institutes of Health/National Center for
   Complementary and Alternative Medicine K23 AT004112 award. The data
   collection is in part supported by grants from the American Cancer
   Society#IRG-78-002-30 and Pennsylvania Department of Aging. The funding
   agency had no role in the design and conduct of this study. We also
   thank Donna Pucci, Dingyun Chan, Jamie Wolf, and Brandon Greene for data
   collection and management.
CR Amanzio M, 2001, PAIN, V90, P205, DOI 10.1016/S0304-3959(00)00486-3
   Barnes Patricia M, 2008, Natl Health Stat Report, P1
   Benedetti F, 2004, NAT NEUROSCI, V7, P587, DOI 10.1038/nn1250
   Berman BM, 2004, ANN INTERN MED, V141, P901, DOI 10.7326/0003-4819-141-12-200412210-00006
   Birch S, 1998, CLIN J PAIN, V14, P248, DOI 10.1097/00002508-199809000-00012
   Bootzin RichardR., 2002, The Science of Placebo: Toward an Interdisciplinary Research Agenda, P108
   Cherkin DC, 2009, ARCH INTERN MED, V169, P858, DOI 10.1001/archinternmed.2009.65
   Coeytaux RR, 2005, HEADACHE, V45, P1113, DOI 10.1111/j.1526-4610.2005.00235.x
   Haake M, 2007, ARCH INTERN MED, V167, P1892, DOI 10.1001/archinte.167.17.1892
   Harris RE, 2009, NEUROIMAGE, V47, P1077, DOI 10.1016/j.neuroimage.2009.05.083
   Kalauokalani D, 2001, SPINE, V26, P1418, DOI 10.1097/00007632-200107010-00005
   Kirsch I., 1990, CHANGING EXPECTATION
   Kirsch I., 1997, The placebo effect: An interdisciplinary exploration, P166
   Kong J, 2009, NEUROIMAGE, V47, P1066, DOI 10.1016/j.neuroimage.2009.05.087
   Kong J, 2009, NEUROIMAGE, V45, P940, DOI 10.1016/j.neuroimage.2008.12.025
   Linde K, 2005, JAMA-J AM MED ASSOC, V293, P2118, DOI 10.1001/jama.293.17.2118
   Linde K, 2007, PAIN, V128, P264, DOI 10.1016/j.pain.2006.12.006
   Linde K, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007587
   Manheimer E, 2005, ANN INTERN MED, V142, P651, DOI 10.7326/0003-4819-142-8-200504190-00014
   Manheimer E, 2007, ANN INTERN MED, V146, P868, DOI 10.7326/0003-4819-146-12-200706190-00008
   Mao JJ, 2009, INTEGR CANCER THER, V8, P123, DOI 10.1177/1534735409332903
   Mao JJ, 2007, EXPLORE-NY, V3, P372, DOI 10.1016/j.explore.2006.12.003
   Mao JJ, 2010, PRIMARY CARE, V37, P105, DOI 10.1016/j.pop.2009.09.010
   Mao JJ, 2009, CANCER, V115, P3631, DOI 10.1002/cncr.24419
   Myers SS, 2008, J GEN INTERN MED, V23, P148, DOI 10.1007/s11606-007-0460-5
   Ratcliffe J, 2006, BRIT MED J, V333, P626, DOI 10.1136/bmj.38932.806134.7C
   Reinhold T, 2008, EUR J HEALTH ECON, V9, P209, DOI 10.1007/s10198-007-0062-5
   Scharf HP, 2006, ANN INTERN MED, V145, P12, DOI 10.7326/0003-4819-145-1-200607040-00005
   Scott DJ, 2008, ARCH GEN PSYCHIAT, V65, P220, DOI 10.1001/archgenpsychiatry.2007.34
   Streiner D., 1998, Health measurement scales, V2nd
   Vickers AJ, 2004, HEALTH TECHNOL ASSES, V8, P1
   Walach Harald, 2005, BMC Med Res Methodol, V5, P26, DOI 10.1186/1471-2288-5-26
   Witt C, 2005, LANCET, V366, P136, DOI 10.1016/S0140-6736(05)66871-7
   Zubieta JK, 2009, ANN NY ACAD SCI, V1156, P198, DOI 10.1111/j.1749-6632.2009.04424.x
NR 34
TC 56
Z9 63
U1 0
U2 1
PU INNOVISION COMMUNICATIONS
PI ALISO VIEJO
PA 101 COLUMBIA, ALISO VIEJO, CA 92656 USA
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD NOV-DEC
PY 2010
VL 16
IS 6
BP 22
EP 27
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA V28TT
UT WOS:000208703800002
PM 21280459
DA 2026-01-16
ER

PT J
AU Lee, DG
   Lee, SH
   Hwang, SW
   Kim, ES
   Eoh, W
AF Lee, Dong-Geun
   Lee, Sun-Ho
   Hwang, Sang-Won
   Kim, Eun-Sang
   Eoh, Whan
TI Myositis ossificans in the paraspinal muscles of the neck after
   acupuncture: a case report
SO SPINE JOURNAL
LA English
DT Article
DE Myositis ossificans; Acupuncture; Cervical spine
ID TRAUMATICA; MIMICKING; BONE
AB BACKGROUND CONTEXT: Although traumatic myositis ossificans (MO) has been reported occasionally, MO of paraspinal muscles has been rarely seen in the cervical spine after minor injury. This is difficult to distinguish from benign and malignant soft lesions in cases of a lack of definite trauma history.
   PURPOSE: We report a case of MO in the cervical paraspinal muscle after acupuncture and describe methods for diagnosis and proper treatment, including classification, etiology, and radiologic and histologic features.
   STUDY DESIGN: Case report.
   METHODS: A 26-year-old woman complained of posterior neck pain that had began 2 months earlier and neck swelling after acupuncture. No abnormal finding existed on the X-ray except soft tissue swelling. Magnetic resonance imaging was evaluated because of constant neck pain. To obtain more accurate assessment, computed tomography-guided biopsy was performed and a diagnosis of MO was made.
   RESULTS: The patient was conservatively treated through rest and analgesics. Posterior neck pain and swelling improved for a several months. The hyperdensity was comparable with the bony density, and the size of the calcified lesion on X-ray diminished until the last follow-up.
   CONCLUSIONS: Myositis ossificans that can occur after acupuncture should be recognized as a possible cause of persistent neck pain and swelling despite no definite trauma after thorough evaluation of the neoplasm and infection. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Lee, Dong-Geun; Lee, Sun-Ho; Hwang, Sang-Won; Kim, Eun-Sang; Eoh, Whan] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg, Seoul 135710, South Korea.
   [Hwang, Sang-Won] Eulji Univ, Sch Med, Taejon 301746, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Eulji University
RP Lee, SH (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg, 50 Ilwon Dong, Seoul 135710, South Korea.
EM sobotta72@hotmail.com
RI Lee, Sun-Ho/AAD-6712-2022
OI Lee, Sun-Ho/0000-0003-3357-4329
CR ACKERMAN LV, 1958, J BONE JOINT SURG AM, V40, P279, DOI 10.2106/00004623-195840020-00004
   Aneiros-Fernandez Jose, 2010, J Clin Med Res, V2, P142, DOI 10.4021/jocmr2010.05.364w
   Baysal T, 1999, EUR RADIOL, V9, P662, DOI 10.1007/s003300050728
   Findlay I, 2010, SPINE, V35, pE1525, DOI 10.1097/BRS.0b013e3181ec066b
   Gould CF, 2007, CURR PROBL DIAGN RAD, V36, P124, DOI 10.1067/j.cpradiol.2007.01.001
   Gunduz B, 2007, INT J REHABIL RES, V30, P87, DOI 10.1097/MRR.0b013e3280146f85
   Kokkosis AA, 2009, PEDIATR RADIOL, V39, P409, DOI 10.1007/s00247-009-1165-1
   LELLO GE, 1986, J MAXILLOFAC SURG, V14, P231, DOI 10.1016/S0301-0503(86)80295-8
   Lin TY, 2011, HEAD NECK-J SCI SPEC, V33, P753, DOI 10.1002/hed.21329
   McCarthy EF, 2005, SKELETAL RADIOL, V34, P609, DOI 10.1007/s00256-005-0958-z
   Meara RS, 2009, CYTOPATHOLOGY, V20, P121, DOI 10.1111/j.1365-2303.2007.00538.x
   Saussez S, 2006, EUR ARCH OTO-RHINO-L, V263, P331, DOI 10.1007/s00405-005-0997-z
   Shin SJ, 2011, CLIN ORTHOP SURG, V3, P81, DOI 10.4055/cios.2011.3.1.81
   Yazici M, 2002, J PEDIATR SURG, V37, P1621, DOI 10.1053/jpsu.2002.36196
NR 14
TC 8
Z9 10
U1 0
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1529-9430
EI 1878-1632
J9 SPINE J
JI Spine Journal
PD JUL
PY 2013
VL 13
IS 7
BP E9
EP E12
DI 10.1016/j.spinee.2013.02.012
PG 4
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 179BG
UT WOS:000321491100003
PM 23523436
DA 2026-01-16
ER

PT J
AU Zhang, H
   Chen, ZY
   Wu, JP
   Chen, N
   Xu, WJ
   Li, TH
   Liu, SP
AF Zhang, Heng
   Chen, Zhenyi
   Wu, Jiping
   Chen, Na
   Xu, Wenjie
   Li, Taihao
   Liu, Shupeng
TI Laser stimulating ST36 with optical fiber induce blood component changes
   in mice: a Raman spectroscopy study
SO JOURNAL OF BIOPHOTONICS
LA English
DT Article
DE acupuncture; laser therapy; optical fiber; Raman scattering; ST36
ID CANCERS
AB ST36 is a commonly-used acupoint in traditional Chinese medicine (TCM) for treatment of inflammations, pains and gastrointestinal disturbs. For decades, the low power laser acupuncture has been widely applied as an alternative therapy to traditional metal needle acupuncture and achieved relatively fine therapeutic effect for ST36-related symptoms with reduction of uncomfortableness and infection risks. However its disadvantages of low penetrativity and lack of manipulation skills limit its potential performance. An optical fiber laser acupuncture introduced by the previous study combines traditional needling acupuncture and the laser stimulation together, making a stronger therapeutic effect and showing a potential value in clinical application. To evaluate its acupunctural effect on blood, mice are taken as experimental model and Raman spectroscopic technique is used to analysis the changes of blood components after stimulating on ST36. The results show that both the traditional needling acupuncture and optical fiber acupuncture could lead to some spectral changes of blood in mice. This study explores the optical fiber acupuncture's effect on blood in mice using Raman spectroscopy technique for mechanism of acupuncture therapy.
C1 [Zhang, Heng; Chen, Zhenyi; Wu, Jiping; Chen, Na; Xu, Wenjie; Liu, Shupeng] Shanghai Univ, Shanghai Inst Adv Commun & Data Sci, Joint Int Res Lab Specialty Fiber Opt & Adv Commu, Key Lab Specialty Fiber Opt & Opt Access Networks, 333 Nanchen Rd, Shanghai 200444, Peoples R China.
   [Li, Taihao] Capital Normal Univ, Beijing Adv Innovat Ctr Imaging Technol, Beijing, Peoples R China.
C3 Shanghai University; Capital Normal University
RP Liu, SP (corresponding author), Shanghai Univ, Shanghai Inst Adv Commun & Data Sci, Joint Int Res Lab Specialty Fiber Opt & Adv Commu, Key Lab Specialty Fiber Opt & Opt Access Networks, 333 Nanchen Rd, Shanghai 200444, Peoples R China.
EM liusp@shu.edu.cn
RI Xu, Wenjie/KBQ-0222-2024; 陈, 娜/A-7723-2016
FU National Natural Science Foundation of China [61475095, 61575120]; Key
   Laboratory of Specialty Fiber Optics and Optical Access Networks
   [SKLSFO2015-06, SKLSFO2017-02]; Natural Science Foundation of China
   (NSFC) [61475095, 61575120, 61520106014, 61422507]
FX National Natural Science Foundation of China, Grant/Award numbers:
   61475095, 61575120; the Key Laboratory of Specialty Fiber Optics and
   Optical Access Networks, Grant/Award number: SKLSFO2015-06 and
   SKLSFO2017-02; Natural Science Foundation of China (NSFC), Grant/Award
   numbers: 61520106014, 61475095, 61422507, 61575120
CR ANDERSON RR, 1981, J INVEST DERMATOL, V77, P13, DOI 10.1111/1523-1747.ep12479191
   [Anonymous], 2006, CHIN J REHABIL THEOR, V5, P64
   Antipa C., 1994, J PHYS 4, V4, pC4
   Azizi A., 2007, J DENT RES DENT CLIN, V1, P2
   Binoy J, 2004, J RAMAN SPECTROSC, V35, P939, DOI 10.1002/jrs.1236
   Cantley LC, 2002, SCIENCE, V296, P1655, DOI 10.1126/science.296.5573.1655
   Chan JW, 2006, BIOPHYS J, V90, P648, DOI 10.1529/biophysj.105.066761
   Chang SL, 2006, LIFE SCI, V79, P967, DOI 10.1016/j.lfs.2006.05.005
   Cheng WT, 2005, MICROSC RES TECHNIQ, V68, P75, DOI 10.1002/jemt.20229
   Cho S. H., 2009, INT J OBESITY, V33, P2
   Deng JL, 2005, J RAMAN SPECTROSC, V36, P257, DOI 10.1002/jrs.1301
   desSouza R. C., 2016, LASER MED SCI, V31, P8
   Dinkins MB, 2001, THERIOGENOLOGY, V55, P1639, DOI 10.1016/S0093-691X(01)00509-X
   Dukor R.K., 2006, HDB VIBRATIONAL SPEC
   Ebneshahidi N. S., 2005, ACUPUNCT MED, V23, P23
   Erthal V., 2016, LASER MED SCI, V31, P2
   Erthal V., 2013, LASER MED SCI, V28, P5
   Faolain E.O., 2005, VIB SPECTROSC, V38, P121, DOI DOI 10.1016/J.VIBSPEC.2005.02.013
   Ferreira Ade S., 2009, J CHIN INTEGR MED, V7, P10
   FRANK CJ, 1995, ANAL CHEM, V67, P777, DOI 10.1021/ac00101a001
   Fu X. U., 2009, CHIN ARCH TRADIT CHI, V3, P110
   GAM AN, 1993, PAIN, V52, P63, DOI 10.1016/0304-3959(93)90114-5
   Geng W. Y., 2013, J INTEGR MED, V11, P3
   Gniadecka M., 1997, J RAMAN SPECTROSC, V28, P2
   Hanlon EB, 2000, PHYS MED BIOL, V45, pR1, DOI 10.1088/0031-9155/45/2/201
   Huang Z., 2003, INT J CANCER, V107, P6
   Jia-Wei R., 2014, SHANGHAI J ACUPUNCTU, V6, P10
   Karatay S., 2011, J ALTERN COMPLEM MED, V17, P4
   Karu T, 2000, PROC SPIE, V4159, P1, DOI 10.1117/12.405918
   Katainen E, 2007, J FORENSIC SCI, V52, P88, DOI 10.1111/j.1556-4029.2006.00306.x
   KING CE, 1990, PHYS THER, V70, P24, DOI 10.1093/ptj/70.1.24
   KIRSCHVINK JL, 1992, BIOELECTROMAGNETICS, P101, DOI 10.1002/bem.2250130710
   Koljenovi S., 2009, ANAL CHEM, V77, P24
   Krafft C, 2005, SPECTROCHIM ACTA A, V61, P1529, DOI 10.1016/j.saa.2004.11.017
   Lakshmi R. J., 2002, RADIAT RES, V157, P2
   Laska J, 2005, POLYMER, V46, P1485, DOI 10.1016/j.polymer.2004.12.008
   Lau D. P., 2003, LASER SURG MED, V32, P3
   Li Z., 1995, APPL LASER, V15, P277
   Liu S., 2016, J INNOV OPT HEAL SCI, V10, P1
   Lodish, INSULIN RECEPTOR ACT, P600
   Malini R, 2006, BIOPOLYMERS, V81, P179, DOI 10.1002/bip.20398
   MESTER E, 1971, AM J SURG, V122, P532, DOI 10.1016/0002-9610(71)90482-X
   Ml D. M. M., 2014, LASER MED SCI, V29, P1
   Mo X., 1996, ACUPUNCTURE RES, V21, P55
   Naumann D, 1998, P SOC PHOTO-OPT INS, V3257, P245, DOI 10.1117/12.306089
   Notingher I., 2011, J R SOC INTERFACE, V1, P1
   Pilla A. A., 2011, REV ENV HLTH, V10, P10
   Pontes MC, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0829-7
   Pontinen P. J., 2010, J MUSCULOSKELET PAIN, V3, P3
   Qiu Y. F., 1999, J HEBEI TRADITIONAL, V14, P3
   Quah-Smith I., 2013, J AFFECT DISORDERS, V148, P2
   Ruiz-Chica AJ, 2004, J RAMAN SPECTROSC, V35, P93, DOI 10.1002/jrs.1107
   Salyaev RK, 2003, LASER PHYS, V13, P839
   Schulz H, 2007, VIB SPECTROSC, V43, P13, DOI 10.1016/j.vibspec.2006.06.001
   Shen T., 2005, J ACUPUNCTURE TUINA, V3, P1
   Shetty G., 2006, BRIT J CANCER, V94, P10
   Silveira L., 2002, LASER SURG MED, V30, P4
   Stone N, 2004, FARADAY DISCUSS, V126, P141, DOI 10.1039/b304992b
   Stone N, 2002, J RAMAN SPECTROSC, V33, P564, DOI 10.1002/jrs.882
   Suhui C., 2016, CHIN J INTEGR MED, V22, P1
   vansGemert M. J., 1989, IEEE T BIOMED ENG, V36, P36
   Wang L., 2013, J EVID BASED COMPLEM, V2013, P4
   Wang Q., 2006, CHINESE J MED ED, V26, P9
   Wang W. J., 2010, ACUPUNCTURE RES, V35, P6
   Wang X., 2007, ACUPUNCTURE RES, V32, P55
   Whittaker P, 2004, LASER MED SCI, V19, P69, DOI 10.1007/s10103-004-0296-8
   Wu Z. C., 2005, J ACUPUNCTURE TUINA, V3, P1
   Xue Q. M., 2013, J EMERG TRADITIONAL, V10, P6
   Yan L. M., 2016, J CLIN ACUPUNCTURE M, V8, P4
   Yan Zhi-kang, 2015, Zhen Ci Yan Jiu, V40, P1
   Yang J., 1989, ZHONG XI YI JIE HE Z, V9, P11
   Yang Y., 1999, J OPTOELECTRON LASER, V10, P568
   Yu Y, 1998, J NEUROIMMUNOL, V90, P176, DOI 10.1016/S0165-5728(98)00143-X
   Yu Z, 2013, NEURAL REGEN RES, V8, P809, DOI 10.3969/j.issn.1673-5374.2013.09.005
   Yu-Chen Lee T.-M. L., 2011, J EVID BASED COMPLEM, V2011, P1741
   Zeredo JL, 2007, LASER MED SCI, V22, P37, DOI 10.1007/s10103-006-0408-8
   Zhang G., 1983, ACUPUNCTURE RES, V1, P64
   Zhang X. H., 1989, ACUPUNCTURE RES, V14, P4
   Zhu J., 2012, EFFECT ACUPUNCTURE B
   Zhuang S. U., 2013, LISHIZHEN MED MAT ME, V24, P8
NR 80
TC 5
Z9 6
U1 2
U2 31
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1864-063X
EI 1864-0648
J9 J BIOPHOTONICS
JI J. Biophotonics
PD JUN
PY 2018
VL 11
IS 6
SI SI
DI 10.1002/jbio.201700262
PG 11
WC Biochemical Research Methods; Biophysics; Optics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Optics
GA GI6VR
UT WOS:000434641700005
PM 29446873
DA 2026-01-16
ER

PT J
AU Chen, JH
   Zhang, YX
   Li, XX
   Wan, Y
   Ji, XQ
   Wang, W
   Kang, XZ
   Yan, WP
   Fan, ZY
AF Chen, Jiheng
   Zhang, Yunxiao
   Li, Xiaoxi
   Wan, You
   Ji, Xinqiang
   Wang, Wei
   Kang, Xiaozheng
   Yan, Wanpu
   Fan, Zhiyi
TI Efficacy of transcutaneous electrical acupoint stimulation combined with
   general anesthesia for sedation and postoperative analgesia in minimally
   invasive lung cancer surgery: A randomized, double-blind,
   placebo-controlled trial
SO THORACIC CANCER
LA English
DT Article
DE Analgesia; general anesthesia; sedation; transcutaneous acupoint
   electrical stimulation; video-assisted thoracoscopic surgery
ID ELDERLY-PATIENTS; PAIN; TOLERANCE; ELECTROACUPUNCTURE; ACUPUNCTURE;
   MODULATION; RECOVERY
AB Background Multimodal opioid-sparing analgesia is a key component of an enhanced recovery pathway after surgery that aims to improve postoperative recovery. Transcutaneous electrical acupoint stimulation (TEAS) is assumed to alleviate pain and anxiety and to modify the autonomic nervous system. This study aimed to determine the efficacy of TEAS for sedation and postoperative analgesia in lung cancer patients undergoing thoracoscopic pulmonary resection.
   Methods A total of 80 patients were randomized into two groups: the TEAS group and the sham TEAS combined with general anesthesia group. Postoperative pain levels at six, 24, 48 hours, and one month after surgery were measured using the visual analogue scale (VAS). Bispectral index (BIS) score during the TEAS prior to anesthetic induction, Observer's Assessment of Alertness/Sedation (OAAS) score, sufentanil consumption during postoperative patient-controlled intravenous analgesia (PCIA), number of total and effective attempts of PCIA pump use, and incidence of postoperative nausea and vomiting were recorded and analyzed statistically.
   Results Patients in the TEAS group had significantly lower VAS scores at six, 24, and 48 hours after surgery (P < 0.01); lower BIS scores at 10, 20, and 30 minutes before induction (P < 0.01); lower levels of postoperative sufentanil consumption; lower number of PCIA attempts and effective rates (P < 0.01); lower incidences of nausea at 0, six, 24, and 48 hours; and lower incidence of vomiting at 24 hours after surgery (P < 0.05). The postoperative OAAS scores were similar between the groups.
   Conclusions TEAS could be a feasible approach for sedation and postoperative analgesia in thoracoscopic pulmonary resection.
C1 [Chen, Jiheng; Zhang, Yunxiao; Li, Xiaoxi; Fan, Zhiyi] Peking Univ, Canc Hosp & Inst, Dept Anesthesiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, 52 Fucheng Rd, Beijing 100142, Peoples R China.
   [Wan, You] Peking Univ, Neurosci Res Inst, Beijing, Peoples R China.
   [Wan, You] Peking Univ, Dept Neurobiol, Beijing, Peoples R China.
   [Wan, You] Minist Educ, Key Lab Neurosci, Beijing, Peoples R China.
   [Wan, You] Natl Hlth Commiss, Beijing, Peoples R China.
   [Ji, Xinqiang; Wang, Wei] Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res,Dept Med Re, Beijing, Peoples R China.
   [Kang, Xiaozheng; Yan, Wanpu] Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res,Dept Thorac, Beijing, Peoples R China.
C3 Peking University; Peking University; Peking University; Peking
   University; Peking University
RP Fan, ZY (corresponding author), Peking Univ, Canc Hosp & Inst, Dept Anesthesiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, 52 Fucheng Rd, Beijing 100142, Peoples R China.
EM jihengchen@bjmu.edu.cn; 13911114196@163.com
RI Wan, You/M-5279-2019; Kang, Xiaozheng/CAF-6485-2022
OI Kang, Xiaozheng/0000-0003-0334-1487
FU Department of Science and Technology, Ministry of Science and Technology
   [National Key R&amp;D Program of China (2017YFC0907504), National Basic
   Research Development Program (973)] Funding Source: Medline; Beijing
   Municipal Administration of Hospitals [Youth Program Grant
   (QML20171106), Special Fund for Digestive System Multidisciplinar]
   Funding Source: Medline
CR Bai WY, 2018, J NEUROSURG ANESTH, V30, P337, DOI 10.1097/ANA.0000000000000460
   Batchelor TJP, 2019, EUR J CARDIO-THORAC, V55, P91, DOI 10.1093/ejcts/ezy301
   Chandran P, 2003, PAIN, V102, P195, DOI 10.1016/S0304-3959(02)00381-0
   DeSantana JM, 2008, ARCH PHYS MED REHAB, V89, P754, DOI 10.1016/j.apmr.2007.11.027
   DeSantana JM, 2010, PAIN, V148, P84, DOI 10.1016/j.pain.2009.10.011
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   Huang S, 2017, J ANESTH, V31, P58, DOI 10.1007/s00540-015-2057-1
   Li HZ, 2019, CLIN INTERV AGING, V14, P1607, DOI 10.2147/CIA.S210751
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   McQuay H, 1999, LANCET, V353, P2229, DOI 10.1016/S0140-6736(99)03528-X
   Myles PS, 2017, BRIT J ANAESTH, V118, P424, DOI 10.1093/bja/aew466
   Tian JH, 1998, BRIT J PHARMACOL, V124, P21, DOI 10.1038/sj.bjp.0701788
   Wang H, 2014, BRIT J ANAESTH, V112, P1075, DOI 10.1093/bja/aeu001
   Wang XQ, 2010, J NEUROSURG ANESTH, V22, P128, DOI 10.1097/ANA.0b013e3181c9fbde
   Wick EC, 2017, JAMA SURG, V152, P691, DOI 10.1001/jamasurg.2017.0898
   Wong RHL, 2006, ANN THORAC SURG, V81, P2031, DOI 10.1016/j.athoracsur.2005.12.064
   Wu MS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150367
   Zhang Q, 2014, ANAESTHESIA, V69, P832, DOI 10.1111/anae.12639
NR 18
TC 48
Z9 62
U1 6
U2 40
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1759-7706
EI 1759-7714
J9 THORAC CANCER
JI Thorac. Cancer
PD APR
PY 2020
VL 11
IS 4
BP 928
EP 934
DI 10.1111/1759-7714.13343
PG 7
WC Oncology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Respiratory System
GA KY5PD
UT WOS:000522621100011
PM 32062864
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wu, J
   Tang, Q
   Tan, XF
AF Wu, Jia
   Tang, Qiong
   Tan, Xiaofei
TI Sodium hyaluronate and acupotomy bone decompression alleviates
   inflammatory responses in patients with knee osteoarthritis
SO INFLAMMOPHARMACOLOGY
LA English
DT Article
DE Knee osteoarthritis; Needle-knife bone decompression surgery; Sodium
   hyaluronate; Bone marrow edema; MRI; Inflammation
ID HIP
AB Objective Knee osteoarthritis (KOA), predominantly affecting middle-aged and elderly populations, induces localized joint pain and functional impairment. It was to evaluate the effectiveness of acupotomy bone decompression (ABD) combined with sodium hyaluronate (SH) intra-articular injection on inflammatory responses in treating KOA. Methods Clinical data from 128 patients with KOA were retrospectively collected, categorized into SH group (n = 55) and ABD + SH group (n = 73). Pain was assessed using the visual analogue scale (VAS), knee joint function was evaluated, and knee joint balance and gait parameters were measured. The status of articular cartilage and bone marrow edema was evaluated using quantitative magnetic resonance imaging (MRI). Interleukin (IL)-6, IL-1 beta, tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-3, MMP-9, and hypersensitive C-reactive protein (hs-CRP) were detected. Results ABD + SH group showed drastic reductions in VAS scores, decreased indices of different axial balances, and increased stride length and walking speed versus the SH group (P < 0.05). Quantitative MRI examination revealed that relative to the SH group, ABD + SH group exhibited increased thickness of articular cartilage and reduced area of bone marrow edema post-treatment (P < 0.05). Post-treatment levels of hs-CRP, IL-6, IL-1 beta, TNF-alpha, MMP-3, and MMP-9 were markedly lower in the ABD + SH group versus SH group (P < 0.05). Moreover, the clinical effective rate in the ABD + SH group was drastically superior to the SH group (95.9% vs. 78.2%, P < 0.05). Conclusion Combining ABD with SH treatment for KOA effectively alleviates patient pain and inflammatory responses.
C1 [Wu, Jia] Sichuan Orthoped Hosp, Dept Rheumatoid Osteoarthrosis, Chengdu 610000, Sichuan, Peoples R China.
   [Tang, Qiong] Peoples Hosp Chongqing Liang Jiang New Area, Dept Radiol, Chongqing 401120, Peoples R China.
   [Tan, Xiaofei] Yunyang Cty Tradit Chinese Med Hosp, Dept Orthoped, Chongqing 404500, Peoples R China.
RP Tan, XF (corresponding author), Yunyang Cty Tradit Chinese Med Hosp, Dept Orthoped, Chongqing 404500, Peoples R China.
EM 796458@finmail.com
RI Tan, Xiaofei/ABD-6971-2021
CR Alghadir AH, 2019, BMC MUSCULOSKEL DIS, V20, DOI 10.1186/s12891-019-2537-9
   Åström M, 2023, QUAL LIFE RES, V32, P2719, DOI 10.1007/s11136-023-03411-3
   Benner RW, 2019, ORTHOP CLIN N AM, V50, P425, DOI 10.1016/j.ocl.2019.05.001
   Deyle GD, 2020, NEW ENGL J MED, V382, P1420, DOI 10.1056/NEJMoa1905877
   Dulic O, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57111193
   Gilbert AL, 2021, ARTHRIT CARE RES, V73, P559, DOI 10.1002/acr.24159
   Giorgino R, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24076405
   Hall M, 2022, OSTEOARTHR CARTILAGE, V30, P32, DOI 10.1016/j.joca.2021.09.010
   Hesper T, 2014, SKELETAL RADIOL, V43, P1429, DOI 10.1007/s00256-014-1852-3
   Ivkovic A, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11071799
   Kan HS, 2019, HONG KONG MED J, V25, DOI 10.12809/hkmj187600
   Kang N, 2022, SPORTS MED HLTH SCI, V4, P239, DOI 10.1016/j.smhs.2022.10.001
   Ko JH, 2019, KNEE, V26, P317, DOI 10.1016/j.knee.2019.01.010
   Li XY, 2017, BIOCHEM BIOPH RES CO, V493, P100, DOI 10.1016/j.bbrc.2017.09.068
   Liew JW, 2023, OSTEOARTHR CARTILAGE, V31, P1234, DOI 10.1016/j.joca.2023.04.015
   Lozano-Meca J, 2024, MUSCULOSKEL SCI PRAC, V72, DOI 10.1016/j.msksp.2024.102983
   Moshi MR, 2023, CALCIFIED TISSUE INT, V112, P631, DOI 10.1007/s00223-023-01078-z
   Primorac D, 2020, GENES-BASEL, V11, DOI 10.3390/genes11080854
   Raeissadat SA, 2021, BMC MUSCULOSKEL DIS, V22, DOI 10.1186/s12891-021-04017-x
   Rampersaud YR, 2008, SPINE J, V8, P296, DOI 10.1016/j.spinee.2007.05.003
   Schwarting J, 2024, EUR RADIOL, V34, P3115, DOI 10.1007/s00330-023-10327-6
   Sukerkar PA, 2022, RADIOL CLIN N AM, V60, P605, DOI 10.1016/j.rcl.2022.03.004
   Sun CG, 2020, J ORTHOP SURG RES, V15, DOI 10.1186/s13018-020-01838-9
   Sun G, 2019, BIOSCIENCE REP, V39, DOI [10.1042/BSR20181346, 10.1042/bsr20181346]
   Tang JZ, 2020, J ORTHOP SURG RES, V15, DOI 10.1186/s13018-020-01919-9
   Thomas DT, 2022, BMC MUSCULOSKEL DIS, V23, DOI 10.1186/s12891-022-05557-6
   Tsubosaka M, 2024, J BIOMED MATER RES B, V112, DOI 10.1002/jbm.b.35360
   Tu JF, 2021, ARTHRITIS RHEUMATOL, V73, P448, DOI 10.1002/art.41584
   Watrin A, 2001, RADIOLOGY, V219, P395, DOI 10.1148/radiology.219.2.r01ma32395
   Webner D, 2021, CARTILAGE, V13, p1619S, DOI 10.1177/19476035211017320
   Welsch GH, 2022, KNEE SURG SPORT TR A, V30, P1161, DOI 10.1007/s00167-022-06897-5
   Xu Q, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000028540
   Yang ZY, 2015, ORTHOPEDICS, V38, pE1110, DOI 10.3928/01477447-20151120-08
   Yenamandra AK, 2022, CANCER GENET-NY, V268, P1, DOI 10.1016/j.cancergen.2022.07.006
NR 34
TC 2
Z9 2
U1 3
U2 6
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD APR
PY 2025
VL 33
IS 4
BP 1997
EP 2005
DI 10.1007/s10787-025-01667-4
EA FEB 2025
PG 9
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA 1HE5C
UT WOS:001427380200001
PM 39976668
DA 2026-01-16
ER

PT J
AU Tao, WW
   Luo, X
   Cui, B
   Liang, DP
   Wang, CL
   Duan, YY
   Li, XF
   Zhou, SY
   Zhao, MJ
   Li, Y
   He, YM
   Wang, SW
   Kelley, KW
   Jiang, P
   Liu, QT
AF Tao, Weiwei
   Luo, Xi
   Cui, Bai
   Liang, Dapeng
   Wang, Chunli
   Duan, Yangyang
   Li, Xiaofen
   Zhou, Shiyu
   Zhao, Mingjie
   Li, Yi
   He, Yumin
   Wang, Shaowu
   Kelley, Keith W.
   Jiang, Ping
   Liu, Quentin
TI Practice of traditional Chinese medicine for psycho-behavioral
   intervention improves quality of life in cancer patients: A systematic
   review and meta-analysis
SO ONCOTARGET
LA English
DT Article
DE traditional Chinese medicine; psycho-behavioral interventions; quality
   of life; cancer; meta-analysis
ID RANDOMIZED CONTROLLED-TRIAL; BREAST-CANCER; TAI-CHI; COLORECTAL-CANCER;
   HEALTH; SYMPTOMS; FATIGUE; ACUPUNCTURE; DEPRESSION; MANAGEMENT
AB Background: Cancer patients suffer from diverse symptoms, including depression, anxiety, pain, and fatigue and lower quality of life (QoL) during disease progression. This study aimed to evaluate the benefits of Traditional Chinese Medicine psycho-behavioral interventions (TCM PBIs) on improving QoL by meta-analysis.
   Methods: Electronic literature databases (PubMed, CNKI, VIP, and Wanfang) were searched for randomized, controlled trials conducted in China. The primary intervention was TCM PBIs. The main outcome was health-related QoL (HR QoL) post-treatment. We applied standard meta analytic techniques to analyze data from papers that reached acceptable criteria.
   Results: The six TCM PBIs analyzed were acupuncture, Chinese massage, Traditional Chinese Medicine five elements musical intervention (TCM FEMI), Traditional Chinese Medicine dietary supplement (TCM DS), Qigong and Tai Chi. Although both TCM PBIs and non-TCM PBIs reduced functional impairments in cancer patients and led to pain relief, depression remission, reduced time to flatulence following surgery and sleep improvement, TCM PBIs showed more beneficial effects as assessed by reducing both fatigue and gastrointestinal distress. In particular, acupuncture relieved fatigue, reduced diarrhea and decreased time to flatulence after surgery in cancer patients, while therapeutic Chinese massage reduced time to flatulence and time to peristaltic sound.
   Conclusion: These findings demonstrate the efficacy of TCM PBIs in improving QoL in cancer patients and establish that TCM PBIs represent beneficial adjunctive therapies for cancer patients.
C1 [Tao, Weiwei; Luo, Xi; Cui, Bai; Liang, Dapeng; Wang, Chunli; Liu, Quentin] Dalian Med Univ, Ctr Canc, Inst Canc Stem Cell, Dalian, Peoples R China.
   [Tao, Weiwei; Luo, Xi; Cui, Bai; Liang, Dapeng; Wang, Chunli; Liu, Quentin] Sun Yat Sen Univ, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Ctr Canc, Guangzhou, Guangdong, Peoples R China.
   [Tao, Weiwei] Dalian Med Univ, Coll Nursing, Dalian, Peoples R China.
   [Duan, Yangyang; Wang, Shaowu] Dalian Med Univ, Dept Radiol, Affiliated Hosp 2, Dalian, Peoples R China.
   [Li, Xiaofen] Dalian Med Univ, Sch Publ Hlth, Dalian, Peoples R China.
   [Zhou, Shiyu] Dalian Med Univ, Dept Psychol, Dalian, Peoples R China.
   [Zhao, Mingjie] Dalian Med Univ Magazine, Dalian, Peoples R China.
   [Li, Yi] Dalian Med Univ, Sch Art, Dalian, Peoples R China.
   [He, Yumin] Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China.
   [Kelley, Keith W.] Coll ACES, Dept Anim Sci, Integrat Immunol & Behav Program, Urbana, IL USA.
   [Kelley, Keith W.] Univ Illinois, Coll Med, Dept Pathol, Urbana, IL USA.
   [Jiang, Ping] Dalian Med Univ, Grad Sch, Dalian, Peoples R China.
C3 Dalian Medical University; Sun Yat Sen University; State Key Lab
   Oncology South China; Dalian Medical University; Dalian Medical
   University; Dalian Medical University; Dalian Medical University; Dalian
   Medical University; Shanghai University of Traditional Chinese Medicine;
   University of Illinois System; University of Illinois Urbana-Champaign;
   Dalian Medical University
RP Liu, QT (corresponding author), Dalian Med Univ, Ctr Canc, Inst Canc Stem Cell, Dalian, Peoples R China.
EM wsw_2003@163.com; kwkelley@illinois.edu; dywx.2009@163.com;
   liuqiang@dlmedu.edu.cn
RI ; Duan, Yangyang/HZL-0371-2023
OI Kelley, Keith W/0000-0002-6837-8793; 
FU China Central Budget Recruitment Program of High-Level Overseas Talent
   [GDW 201221022066]; National Basic Research Program of China (973
   Program) [2012CB967000]; Program for Changjiang Scholars and Innovative
   Research Team in Universities [ITR 13049]; NIH [RO1 SUB UT00000712];
   National Natural Science Foundation of China (NNSF) [81130040,
   81201686];  [NSF 2014029102]
FX This work was supported by the China Central Budget Recruitment Program
   of High-Level Overseas Talent (GDW 201221022066 to Q. Liu), the National
   Basic Research Program of China (973 Program: No. 2012CB967000 to Q.
   Liu), the Program for Changjiang Scholars and Innovative Research Team
   in Universities (ITR 13049 to Q. Liu), a NIH grant (RO1 SUB UT00000712
   to K. W. Kelley), the National Natural Science Foundation of China (NNSF
   No. 81130040 to Q. Liu and No. 81201686 to J. Xu), and the Liaoning (NSF
   2014029102 to Q. Liu).
CR Ahlberg K, 2003, LANCET, V362, P640, DOI 10.1016/S0140-6736(03)14186-4
   Andersen BL, 2007, BRAIN BEHAV IMMUN, V21, P953, DOI 10.1016/j.bbi.2007.03.005
   王运良, 2012, [中华物理医学与康复杂志, Chinese Journal of Physical Medicine and Rehabilitation], V34, P64
   [Anonymous], EFFECT TRADITIONAL C
   [Anonymous], CHIN J MOD NURS
   [Anonymous], 2013, Chin Nurs Res
   [Anonymous], NATL HLTH STAT REPOR
   [Anonymous], CHIN J MOD NURS
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], OVERVIEW EVIDENCE BA
   [Anonymous], MODERN NURSING
   [Anonymous], ANN BEHAV MED
   Balk Judith, 2009, J Soc Integr Oncol, V7, P4
   Blesch K S, 1991, Oncol Nurs Forum, V18, P81
   Bower JE, 2000, J CLIN ONCOL, V18, P743, DOI 10.1200/JCO.2000.18.4.743
   Bower JE, 2011, J CLIN ONCOL, V29, P3517, DOI 10.1200/JCO.2011.36.1154
   Bradt J, 2011, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD006911, 10.1002/14651858.CD006911.pub4, 10.1002/14651858.CD006911.pub2]
   Bruera E, 2010, J CLIN ONCOL, V28, P3671, DOI 10.1200/JCO.2010.29.8984
   Campo RA, 2013, INTEGR CANCER THER, V12, P464, DOI 10.1177/1534735413485418
   Chen Z, 2013, CANCER-AM CANCER SOC, V119, P1690, DOI 10.1002/cncr.27904
   Chung JH, 2013, WORLD J MENS HEALTH, V31, P157, DOI 10.5534/wjmh.2013.31.2.157
   Cleeland CS, 2013, CANCER-AM CANCER SOC, V119, P4333, DOI 10.1002/cncr.28376
   Dahlquist Lynnda M, 2002, J Pediatr Oncol Nurs, V19, P22, DOI 10.1053/jpon.2002.30009
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   deGramont A, 1997, J CLIN ONCOL, V15, P808, DOI 10.1200/JCO.1997.15.2.808
   Deng G, 2013, SUPPORT CARE CANCER, V21, P1735, DOI 10.1007/s00520-013-1720-z
   Epplein M, 2011, J CLIN ONCOL, V29, P406, DOI 10.1200/JCO.2010.30.6951
   Eremin O, 2009, BREAST, V18, P17, DOI 10.1016/j.breast.2008.09.002
   Fallowfield L, 2001, BRIT J CANCER, V84, P1011, DOI 10.1054/bjoc.2001.1724
   Freise H, 2011, BRIT J ANAESTH, V107, P859, DOI 10.1093/bja/aer339
   Giese-Davis J, 2011, J CLIN ONCOL, V29, P413, DOI 10.1200/JCO.2010.28.4455
   HANSEL TT, 1991, CLIN EXP IMMUNOL, V86, P271
   Harper A, 1998, PSYCHOL MED, V28, P551, DOI 10.1017/S0033291798006667
   Henderson V, 2012, BREAST CANCER RES TR, V131, P99, DOI 10.1007/s10549-011-1738-1
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Ho YH, 1996, DIS COLON RECTUM, V39, P307, DOI 10.1007/BF02049473
   Hollingworth W, 2013, J CLIN ONCOL, V31, P3631, DOI 10.1200/JCO.2012.48.3040
   Irwin MR, 2008, SLEEP, V31, P1001
   Janelsins MC, 2011, CLIN BREAST CANCER, V11, P161, DOI 10.1016/j.clbc.2011.03.013
   Jeon Soon-Yang, 2005, Taehan Kanho Hakhoe Chi, V35, P135
   Johnston MF, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-49
   Krischer MM, 2007, J CLIN ONCOL, V25, P4657, DOI 10.1200/JCO.2006.09.0126
   Lämås K, 2009, INT J NURS STUD, V46, P759, DOI 10.1016/j.ijnurstu.2009.01.007
   Lang EV, 2000, LANCET, V355, P1486, DOI 10.1016/S0140-6736(00)02162-0
   Lavretsky H, 2011, AM J GERIAT PSYCHIAT, V19, P839, DOI 10.1097/JGP.0b013e31820ee9ef
   LECROY CW, 1992, SOC WORK, V37, P225
   Legge MF, 1999, IEEE ENG MED BIOL, V18, P80, DOI 10.1109/51.752983
   Li Z. Y., 2012, ZHONGGUO SHIYAN FANG, V18, P332
   Meric-Bernstam F, 2013, J CLIN ONCOL, V31, P1849, DOI 10.1200/JCO.2012.45.3043
   Mielenz T, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-66
   Mishra SI, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007566.pub2
   Nolan RP, 2010, HYPERTENSION, V55, P1033, DOI 10.1161/HYPERTENSIONAHA.109.146233
   Osborn RL, 2006, INT J PSYCHIAT MED, V36, P13, DOI 10.2190/EUFN-RV1K-Y3TR-FK0L
   Paskett ED, 2008, CANCER-AM CANCER SOC, V113, P3222, DOI 10.1002/cncr.23891
   [强万敏 QIANG Wanmin], 2011, [中华护理杂志, Chinese Journal of Nursing], V46, P537
   Rodgers A, 2000, BMJ-BRIT MED J, V321, P1493, DOI 10.1136/bmj.321.7275.1493
   Sniezek DP, 2013, MED ACUPUNCT, V25, P164, DOI 10.1089/acu.2012.0900
   Temel JS, 2010, NEW ENGL J MED, V363, P733, DOI 10.1056/NEJMoa1000678
   Theodoropoulos GE, 2013, TECH COLOPROCTOL, V17, P525, DOI 10.1007/s10151-013-1008-9
   van der Meulen IC, 2013, ONCOLOGIST, V18, P336, DOI 10.1634/theoncologist.2012-0299
   Viechtbauer W, 2010, J STAT SOFTW, V36, P1, DOI 10.18637/jss.v036.i03
   Wadler S, 1998, J CLIN ONCOL, V16, P3169, DOI 10.1200/JCO.1998.16.9.3169
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   Weis J, 2011, EXPERT REV PHARM OUT, V11, P441, DOI [10.1586/erp.11.44, 10.1586/ERP.11.44]
   [项春雁 XIANG Chunyan], 2006, [中华护理杂志, Chinese Journal of Nursing], V41, P969
   Yan X, 2006, INT J BIOCHEM CELL B, V38, P2102, DOI 10.1016/j.biocel.2006.06.002
   Yeh ML, 2006, CANCER NURS, V29, P149, DOI 10.1097/00002820-200603000-00012
   Yu JF, 2002, CHIN J NURS, V37, P799
   Zeng YC, 2014, COMPLEMENT THER MED, V22, P173, DOI 10.1016/j.ctim.2013.11.010
   Zhang J, 2012, J ALTERN COMPLEM MED, V18, P994, DOI 10.1089/acm.2011.0514
NR 70
TC 69
Z9 79
U1 4
U2 73
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD NOV 24
PY 2015
VL 6
IS 37
BP 39725
EP 39739
DI 10.18632/oncotarget.5388
PG 15
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Cell Biology
GA CY0RW
UT WOS:000366114400032
PM 26498685
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Minchom, A
   Punwani, R
   Filshie, J
   Bhosle, J
   Nimako, K
   Myerson, J
   Gunapala, R
   Popat, S
   O'Brien, MER
AF Minchom, A.
   Punwani, R.
   Filshie, J.
   Bhosle, J.
   Nimako, K.
   Myerson, J.
   Gunapala, R.
   Popat, S.
   O'Brien, M. E. R.
TI A randomised study comparing the effectiveness of acupuncture or
   morphine versus the combination for the relief of dyspnoea in patients
   with advanced non-small cell lung cancer and mesothelioma
SO EUROPEAN JOURNAL OF CANCER
LA English
DT Article
DE Lung cancer; Acupuncture; Dyspnoea
ID CONTROLLED-TRIAL; PALLIATIVE CARE; PLACEBO; BREATHLESSNESS; PAIN
AB Background: Dyspnoea is one of the commonest symptoms of lung cancer. Opioids can reduce dyspnoea. This study investigates acupuncture for relief of breathlessness in lung cancer.
   Methods: We performed a single-centre, randomised phase II study of 173 patients with non-small cell lung cancer or mesothelioma with dyspnoea score of >= 4 on visual analogue scale (VAS). Randomisation was to acupuncture alone (A), morphine alone (M) or both (AM). Acupuncture was administered at upper sternal, thoracic paravertebral, trapezius trigger points and LI4. Manubrial semi-permanent acupuncture studs were inserted and massaged when symptomatic. Arm A patients received rescue morphine. Primary end-point was proportion of patients achieving >= 1.5 improvement in VAS dyspnoea at 4 h. Measurements continued to day 14 and included VAS relaxation, line analogue rating (Lar) anxiety, hospital anxiety and depression and European Organisation for Research and Treatment of Cancer quality-of-life scores.
   Results: Dyspnoea VAS improved >= 1.5 in 74%, 60% and 66% of arms A, M and AM, respectively, and was maintained in 45% at 2 weeks. There was no statistically significant difference between arms. VAS relaxation improved in arms A (1.06 points) and AM (1.48 points) compared to arm M (-0.19 points, p < 0.001). At 7 d, the Lar anxiety score improved in arm A (1.5 points), arm AM (1.2 points) and arm M (no change, p=0.003). Fewer patients received at least one morphine dose in arm A compared with arm M or AM (21% versus 87% versus 87%, respectively, p < 0.001).
   Conclusions: A, M and AM were effective in relieving dyspnoea. Acupuncture relieved anxiety and was morphine sparing, providing an alternative to morphine. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Minchom, A.; Punwani, R.; Bhosle, J.; Nimako, K.; Myerson, J.; Gunapala, R.; Popat, S.; O'Brien, M. E. R.] Royal Marsden Hosp, Lung Unit, Sutton, Surrey, England.
   [Filshie, J.] Royal Marsden Hosp, Dept Anaesthet & Pain Management, Sutton, Surrey, England.
C3 Royal Marsden NHS Foundation Trust; Royal Marsden NHS Foundation Trust
RP O'Brien, MER (corresponding author), Royal Marsden Hosp, Lung Unit, Sutton, Surrey, England.
EM mary.o'brien@rmh.nhs.uk
RI Popat, Sanjay/AAO-1634-2021
OI Popat, Sanjay/0000-0003-2087-4963; Minchom, Anna/0000-0002-9339-7101
FU National Institute for Health Research Biomedical Research Centre;
   Aqualung Charity [1108352]
FX This work was supported by the National Institute for Health Research
   Biomedical Research Centre and the Aqualung Charity ( charity no.
   1108352, no longer operating).
CR AITKEN RCB, 1969, P ROY SOC MED, V62, P989, DOI 10.1177/003591576906201005
   Bausewein C, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005623.pub2
   Bjelland I, 2002, J PSYCHOSOM RES, V52, P69, DOI 10.1016/S0022-3999(01)00296-3
   CHENG RSS, 1980, LIFE SCI, V26, P631, DOI 10.1016/0024-3205(80)90239-8
   Dorman S, 2007, PALLIATIVE MED, V21, P177, DOI 10.1177/0269216307076398
   Ernst E, 1998, CANCER-AM CANCER SOC, V83, P777, DOI 10.1002/(SICI)1097-0142(19980815)83:4<777::AID-CNCR22>3.0.CO;2-O
   Filshie J, 1996, PALLIATIVE MED, V10, P145, DOI 10.1177/026921639601000209
   Henry NL, 2015, J CLIN ONCOL, V33, P1870, DOI 10.1200/JCO.2015.61.1004
   Jennings AL, 2001, COCHRANE DB SYST REV, V4
   JOBST K, 1986, LANCET, V2, P1416, DOI 10.1016/S0140-6736(86)92732-7
   Kim SK, 2010, AUTON NEUROSCI-BASIC, V157, P38, DOI 10.1016/j.autneu.2010.03.010
   Leng G, 2013, ACUPUNCT MED, V31, P16, DOI 10.1136/acupmed-2012-010230
   Lu WD, 2013, CURR PAIN HEADACHE R, V17, DOI 10.1007/s11916-013-0321-3
   Lund Irene, 2006, Acupunct Med, V24, P13
   O'Driscoll M, 1999, EUR J CANCER CARE, V8, P37
   Pariente J, 2005, NEUROIMAGE, V25, P1161, DOI 10.1016/j.neuroimage.2005.01.016
   PARROTT AC, 1980, PSYCHOPHARMACOLOGY, V71, P173, DOI 10.1007/BF00434408
   Pilkington Karen, 2007, Acupunct Med, V25, P1
   Pomeranz B., 2001, CLIN ACUPUNCTURE SCI
   Rubens C, 2016, MED ACUPUNC IN PRESS
   Streitberger K, 1998, LANCET, V352, P364, DOI 10.1016/S0140-6736(97)10471-8
   Suzuki M, 2012, ARCH INTERN MED, V172, P878, DOI 10.1001/archinternmed.2012.1233
   Towler P, 2013, SUPPORT CARE CANCER, V21, P2913, DOI 10.1007/s00520-013-1882-8
   UvnasMoberg K, 1997, ANN NY ACAD SCI, V807, P146, DOI 10.1111/j.1749-6632.1997.tb51917.x
   Vickers AJ, 2005, BMC PALLIAT CARE, V4
   Walker J, 2014, LANCET ONCOL, V15, P1168, DOI 10.1016/S1470-2045(14)70343-2
   Wu HS, 2004, J ADV NURS, V45, P252, DOI 10.1046/j.1365-2648.2003.02886.x
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
NR 28
TC 38
Z9 45
U1 1
U2 39
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0959-8049
EI 1879-0852
J9 EUR J CANCER
JI Eur. J. Cancer
PD JUL
PY 2016
VL 61
BP 102
EP 110
DI 10.1016/j.ejca.2016.03.078
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA DN9FK
UT WOS:000377384700013
PM 27156228
DA 2026-01-16
ER

PT J
AU Lam, WC
   Zhong, LD
   Liu, YQ
   Shi, NN
   Ng, B
   Ziea, E
   Bian, ZX
   Lu, AP
AF Lam, Wai Ching
   Zhong, Linda
   Liu, Yuqi
   Shi, Nannan
   Ng, Bacon
   Ziea, Eric
   Bian, Zhaoxiang
   Lu, Aiping
TI Hong Kong Chinese Medicine Clinical Practice Guideline for Cancer
   Palliative Care: Pain, Constipation, and Insomnia
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
AB It is common for patients with cancers in Hong Kong seeking Chinese Medicine (CM) therapies as supportive care during cancer treatment and to manage treatment-related side effects. This article provides clinical practice guideline (CPG) on the use of CM for specific clinical indications caused by cancer and during cancer treatment, including pain, constipation, and insomnia, and aims to guide local licensed CM practitioners and provide beneficial reference for social medical decision makers and patients. In this manuscript, we summarize the clinical manifestation, CM pattern classification, and CM intervention including herbal treatment, acupuncture treatment, regulating, and nursing based on pattern differentiation.
C1 [Lam, Wai Ching; Zhong, Linda; Bian, Zhaoxiang; Lu, Aiping] Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong Chinese Med Clin Study Ctr, Kowloon, Hong Kong 999077, Peoples R China.
   [Liu, Yuqi; Shi, Nannan] China Acad Chinese Med Sci, Beijing 100700, Peoples R China.
   [Ng, Bacon; Ziea, Eric] Hong Kong Hosp Author, Dept Chinese Med, Kowloon, Hong Kong 999077, Peoples R China.
C3 Hong Kong Baptist University; China Academy of Chinese Medical Sciences
RP Lu, AP (corresponding author), Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong Chinese Med Clin Study Ctr, Kowloon, Hong Kong 999077, Peoples R China.
EM aipinglu@hkbu.edu.hk
RI LU, Aiping/JDX-0577-2023; Zhong, Linda/AAI-7376-2021; Ng, Bacon F
   L/I-5554-2013; Shi, Nannan/LTD-9501-2024
OI LU, Aiping/0000-0002-2303-0494; Zhong, Linda/0000-0002-3877-1914; Ng,
   Bacon F L/0000-0003-1682-8382; LAM, Wai Ching/0000-0001-9137-1445; 
FU Hong Kong Hospital Authority Research Fund [HA 33-14-110-542-130]
FX The research and publication were funded by Hong Kong Hospital Authority
   Research Fund [HA 33-14-110-542-130].
CR [Anonymous], 2011, EVIDENCE BASED GUIDE
   [Anonymous], 2013, J LIAONING U TCM
   Bao Y, 2014, EVID-BASED COMPL ALT, V2014, P9, DOI DOI 10.1155/2014/
   BERGER A, 2002, JOURNAL OF PAIN AND, V33, P398
   Berger Ann M, 2010, Oncol Nurs Forum, V37, pE359, DOI 10.1188/10.ONF.E359-E369
   Burton AW, 2014, CURR OPIN SUPPORT PA, V8, P112, DOI 10.1097/SPC.0000000000000047
   Cai P, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000012888
   Carmady B, 2011, CHIN MED-UK, V6, DOI 10.1186/1749-8546-6-22
   CHEN C, 2002, CHINESE JOURNAL OF I, V20, P496
   CHENG C, 2002, SUPPORTIVE CARE IN C, V21, P149
   CHENG CW, 2012, EVID BASED COMPL ALT
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Chung VCH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002793
   Cramer H, 2016, MEDICINE, V95, P2901
   Curtis E B, 1991, J Palliat Care, V7, P25
   Davidson JR, 2002, SOC SCI MED, V54, P1309, DOI 10.1016/S0277-9536(01)00043-0
   DEANDREA S, 2002, JOURNAL OF PAIN AND, V47, P57
   Duan K.-N., 2009, W CHINA MED J, V24, P9
   Fallon M.T., 1999, European Journal of Pain, V3, P3, DOI [DOI 10.1016/S1090-3801(99)90169-6, 10.1016/S1090-3801(99)90169-6]
   Fan D., 2014, JOURNAL OF PRACTICAL, V1, P109
   Feng J., 2011, LIAONING J TRADITION, V38, P1612
   Feng Y, 2011, J TRADIT CHIN MED, V31, P199, DOI 10.1016/S0254-6272(11)60042-3
   Gao H., 2007, LIAONING J TRADITION, V34, P612
   GOUDAS L, 2002, CANCER INVEST, V23, P182
   HADDAD N, 2002, INTEGR CANCER THER, V13, P371
   Hu H. J., 2014, J CHENGDU U TRADITIO, V37, P85
   Hu H.-J., 2014, J CHENGDU U TRADITIO, V37, P76
   Jianhong H., 2013, GUANGMING J CHINESE, V28, P2073
   Kang F., 2013, J Hunan Univ Tradit Chin Med, V33, P31
   Kim W, 2015, COMPLEMENT THER MED, V23, P626, DOI 10.1016/j.ctim.2015.03.011
   Koopman Cheryl, 2002, Breast J, V8, P362, DOI 10.1046/j.1524-4741.2002.08606.x
   Larkin PJ, 2008, PALLIATIVE MED, V22, P796, DOI 10.1177/0269216308096908
   LAUGSAND E, 2002, MANAGEMENT, V5, P11
   Le Guen Y, 2007, LUNG CANCER, V58, P139, DOI 10.1016/j.lungcan.2007.05.021
   Li H., 2010, MED RECAPITULATE, V16, P2531
   Li J.-Y., 2013, J TRADITIONAL CHINES, V33, P76
   Li K., 2013, JILIN J TRADITIONAL, V33, P1029
   Liu Jian-Ping, 2007, Zhongguo Zhong Xi Yi Jie He Za Zhi, V27, P1061
   LU W, 2002, CURRENT PAIN AND HEA, V17, P321
   MERCADANTE S, 2002, SUPPORTIVE CARE IN C, V12, P355
   Ning N, 2014, J CIRCUIT SYST COMP, V23, DOI 10.1142/S0218126614500066
   Palesh OG, 2010, J CLIN ONCOL, V28, P292, DOI 10.1200/JCO.2009.22.5011
   PALEY C, 2002, COCHRANE DB SYST REV, V19, P1
   Pan G., 2014, HENAN TRADITIONAL CH, V34, P1332
   PENG H, 2002, CHINESE, V8, P501, DOI DOI 10.3736/JCIM20100601
   PORTENOY R, 2000, LANCET, V377, P2236
   Potter J, 2003, PALLIATIVE MED, V17, P310, DOI 10.1191/0269216303pm760oa
   Qiao X., 2012, GUANGMING J CHINESE, V27, P2016
   Rao SSC, 2016, NAT REV GASTRO HEPAT, V13, P295, DOI 10.1038/nrgastro.2016.53
   ROMITO F, 2002, EUROPEAN JOURNAL OF, V23, P385
   Savard J, 2001, SLEEP, V24, P583, DOI 10.1093/sleep/24.5.583
   SAVARD J, 2002, JCO, V19, P895
   Savard J, 2011, J CLIN ONCOL, V29, P3580, DOI 10.1200/JCO.2010.33.2247
   SELA R, 2002, PALLIAT SUPPORT CARE, V3, P23
   SHAM M, 2002, J PAIN PALLIATIVE CA, V17, P65
   Shi NN, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/482706
   SMITH M, 2002, SEMINARS ONCOLOGY NU, V28, P64
   Tan G.S., 2012, World J Integr Med, V7, P147
   Tao WW, 2015, ONCOTARGET, V6, P39725, DOI 10.18632/oncotarget.5388
   The Hong Kong Cancer Registry (HKCaR), OV HONG KONG CANC ST
   The Hospital Authority, 2018, HOSP AUTH LAUNCH INT
   Tsai JS, 2006, PALLIATIVE MED, V20, P617, DOI 10.1177/0269216306071065
   Vinjamury SP, 2013, CHIN MED-UK, V8, DOI 10.1186/1749-8546-8-15
   Wang Ju-yong, 2011, Zhong Xi Yi Jie He Xue Bao, V9, P129, DOI 10.3736/jcim20110202
   Wang M., 2013, J PRACT TRADITIONAL, V27, P79, DOI [10.3969/j.issn.1671-7813.2013.06(x).40, DOI 10.3969/J.ISSN.1671-7813.2013.06(X).40]
   XIANGYONG Y, 2002, SUPPORT CARE CANCER, V24, P11
   XU L, 2002, INTEGR CANCER THER, V6, P208
   Yu Chien-Tai, 2010, Hu Li Za Zhi, V57, P100
   ZHANG L, 2009, XINJIANG JOURNAL OF, V6, P6
   Zhao W., 2006, MODERN ONCOL, V14, P1286
   Zheng G, 2011, BIODATA MIN, V4, DOI 10.1186/1756-0381-4-18
   Zhenxiong H., 2007, J PRACTICAL TRADITIO, V23, P213
   Zhu Shi-jie, 2011, Zhong Xi Yi Jie He Xue Bao, V9, P11
   1998, JAMA-J AM MED ASSOC, V280, P1518, DOI DOI 10.1001/JAMA.280.17.1518
NR 74
TC 19
Z9 25
U1 1
U2 27
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2019
VL 2019
AR 1038206
DI 10.1155/2019/1038206
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA HV9VT
UT WOS:000466331000001
PM 30805017
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Panicker, L
   Prasun, MA
   Stockmann, C
   Simon, J
AF Panicker, Latha
   Prasun, Marilyn A.
   Stockmann, Cherrill
   Simon, Jolene
TI Evaluation of Chronic, Noncancer Pain Management Initiative in a
   Multidisciplinary Pain Clinic
SO PAIN MANAGEMENT NURSING
LA English
DT Article
ID OPIOIDS; REDUCTION; THERAPIES
AB Background: Chronic pain management is a major challenge for primary care providers (PCPs). PCPs manage many patients with chronic pain and other comorbidities including mental health problems like post-traumatic stress disorder (PTSD) and depression. Chronic pain and opioid problems are a national crisis, particularly among veterans (U.S. Department of Veterans Affairs, 2019). There are many veterans with chronic non-cancer pain who are being treated with opioids. Chronic opioid use has contributed to an epidemic of opioid-related adverse events (VA, 2017). Opioids not only result in poor pain control, but have associated risks such as misuse, overdose, and diversion which may be fatal (Frieden & Houry, 2016).
   Aims: The aim of this project was to evaluate chronic non-cancer pain management of veterans using an advanced practice registered nurse (APRN)-led multidisciplinary team approach to incorporate non-opioid and non-pharmacologic modalities to affect self-reported pain and use of prescribed opioids. Methods: A retrospective quality improvement (QI) project was conducted in the multidisciplinary pain (MDP) clinic. The APRN used a biopsychosocial approach for chronic pain management guided by the Plan, Do, Study, Act (PDSA) cycle framework. Thirty-four patients who were utilizing opioids for pain management were included using convenience sampling from the MDP clinic. The APRN educated and treated patients with non-opioid medications and non-pharmacolog therapies. A 10-point pain scale and morphine equivalent daily dose (MEDD) were utilized pre- and post-intervention to evaluate the MDP clinic.
   Results: Participants were predominantly male (91.8%), with a mean age of 63.18 +/- 15.39 years, and 36.4% of whom were retired. Only 20.6% of the participants reported the use of opioids for <12 months. Low back pain (93%) was the most common pain location. The mean baseline MEDD was 41.04 and the post tapered MEDD was 23.05; this revealed a significant decline in MEDD (p <.00 01). A decline was also found between pre- and post-pain scores (ranges 0-8). There was a significant reported decline in pain scores with a baseline of 6.11 to post tapering pain of 3.1 (t = 4.99, df = 28, p <.0 001). Participants preferred non-opioid medications 94% and non-pharmacologic therapy 86%, like physical therapy, yoga, and acupuncture. Fifty-one percent of patients were referred for injections and 46% were referred to primary care behavior health, which includes pain school, sleep hygiene classes, and cognitive behavior therapy.
   Conclusions: APRNs are in a key position to assess and treat patients based on current evidence while facilitating opioid titration. This initiative highlights that safe tapering of opioids is possible when utilizing a multidisciplinary approach for chronic pain management. Findings support the use of non-pharmacologic and non-opioid therapy for chronic pain management which can result in reduced patient-reported pain. Further research is warranted to examine both pharmacologic (non-opioid) and non-pharmacologic strategies that promote pain management while tapering opioids. Published by Elsevier Inc. on behalf of American Society for Pain Management Nursing.
C1 [Panicker, Latha; Prasun, Marilyn A.; Stockmann, Cherrill] Illinois State Univ, Mennonite Coll Nursing, Normal, IL 61761 USA.
   [Panicker, Latha; Simon, Jolene] Edward Hines Jr VA Hosp, Hines, IL USA.
C3 Illinois State University; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Edward Hines Jr. VA Hospital
RP Panicker, L (corresponding author), 800 S Wilmette Ave, Westmont, IL 60559 USA.
EM latha.panicker@va.gov
OI Simon, Jolene/0000-0002-4347-9213; Prasun, Marilyn/0000-0002-3601-0695
CR Ashton-James CE, 2019, PAIN, V160, P1586, DOI 10.1097/j.pain.0000000000001543
   Centers for Disease Control and Prevention (CDC), 2018, CALC TOT DAIL DOS OP
   Centers for Disease Control and Prevention (CDC), 2020, COMPR LOOK DRUG OV U
   Centers for Disease Control and Prevention (CDC), 2019, MAN CHRON PAIN
   Centers for Disease Control and Prevention (CDC), 2019, INF PROV SAF PRESCR
   Centers for Disease Control and Prevention(CDC), 2016, CDC GUID PRESCR OP C
   Chou Roger, 2014, Evid Rep Technol Assess (Full Rep), P1, DOI 10.23970/AHRQEPCERTA218
   Christo PJ, 2020, J LAW MED ETHICS, V48, P241, DOI 10.1177/1073110520935335
   Costello M., 2016, MEDSURG Nursing, V25, P307
   Ding Y., 2020, Total expenses, total utilization, and sources of payment for outpatient prescription opioids in the U.S. adult civilian noninstitutionalized population
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
   Frank JW, 2016, PAIN MED, V17, P1838, DOI 10.1093/pm/pnw078
   Frieden TR, 2016, NEW ENGL J MED, V374, P1501, DOI 10.1056/NEJMp1515917
   Furlan AD, 2011, PAIN RES MANAG, V16, P337, DOI 10.1155/2011/465281
   Gauthier K., 2019, Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines-An Update
   Giron SE, 2015, PAIN MANAG NURS, V16, P819, DOI 10.1016/j.pmn.2015.04.001
   Harden P, 2015, PAIN MED, V16, P1975, DOI 10.1111/pme.12812
   Hassan S, 2020, PAIN MED, V21, P836, DOI 10.1093/pm/pnz291
   Kertesz SG, 2020, J LAW MED ETHICS, V48, P259, DOI 10.1177/1073110520935337
   Kligler BE, 2016, ALTERN COMPLEMENT TH, V22, P237, DOI [10.1089/act.2016.29080.bek, DOI 10.1089/act.2016.29080.bek]
   Krebs EE, 2018, JAMA-J AM MED ASSOC, V319, P872, DOI 10.1001/jama.2018.0899
   Lin LW, 2019, AM J PREV MED, V57, P106, DOI 10.1016/j.amepre.2019.01.016
   Lumish R, 2018, J GERONTOL NURS, V44, P9, DOI 10.3928/00989134-20171213-04
   Mehl-Madrona L, 2016, J ALTERN COMPLEM MED, V22, P621, DOI 10.1089/acm.2015.0212
   Nicholas MK, 2020, PAIN, V161, P509, DOI 10.1097/j.pain.0000000000001763
   Salmond S, 2019, ORTHOP NURS, V38, P95, DOI 10.1097/NOR.0000000000000521
   Sullivan MD, 2017, J PAIN, V18, P308, DOI 10.1016/j.jpain.2016.11.003
   U.S. Department of Veterans Affairs, 2019, TRANSF TREATM CHRON
   U. S. Department of Veterans Affairs, 2017, VA DOD CLIN PRACT GU
   U.S. Food & Drug Administration, 2017, UPDATE FDA DRUG SAFE
   U.S. Government Accountability Office (GAO), MAN RISKS IMPR VA HL
   Weeks E, 2018, KANSAS LAW REV, V67, P1132
   Yi P, 2015, PAIN MED, V16, pS32, DOI 10.1111/pme.12914
NR 33
TC 8
Z9 8
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1524-9042
EI 1532-8635
J9 PAIN MANAG NURS
JI Pain Manag. Nurs.
PD APR
PY 2022
VL 23
IS 2
BP 122
EP 127
DI 10.1016/j.pmn.2021.09.003
EA MAR 2022
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA ZW4ST
UT WOS:000771205500004
PM 34756689
DA 2026-01-16
ER

PT J
AU DeMoss, P
   Ramsey, LH
   Karlson, CW
AF DeMoss, Patrick
   Ramsey, Logan H.
   Karlson, Cynthia Windham
TI Phantom Limb Pain in Pediatric Oncology
SO FRONTIERS IN NEUROLOGY
LA English
DT Review
DE phantom limb pain; pediatrics; cancer; therapy; amputation; children;
   adolescent; treatment
ID MIRROR THERAPY; POSTAMPUTATION PAIN; ADOLESCENT AMPUTEES; AMPUTATION;
   GABAPENTIN; CHILD; AMITRIPTYLINE; SENSATIONS; PLACEBO
AB Phantom limb pain (PLP) is a prevalent problem for children and adolescents undergoing amputation due to cancer treatment. The symptoms are wide ranging from sharp to tingling. PLP in children typically lasts for a few minutes but can be almost constant and can be highly distressing. This focused review describes the characteristics, epidemiology, mechanisms, and evidence-based treatment of PLP in pediatric populations, focusing on pediatric cancer. In pediatric oncology, the administration of chemotherapy is a risk factor that potentially sensitizes the nervous system and predisposes pediatric cancer patients to develop PLP after amputation. Gabapentin, tricyclic antidepressants, opiates, nerve blocks, and epidural catheters have shown mixed success in adults and case reports document potential utility in pediatric patients. Non-pharmacologic treatments, such as mirror therapy, psychotherapy, and acupuncture have also been used in pediatric PLP with success. Prospective controlled trials are necessary to advance care for pediatric patients with PLP.
C1 [DeMoss, Patrick] Univ Mississippi, Med Ctr, Dept Pediat, Jackson, MS 39216 USA.
   [Ramsey, Logan H.] Univ Mississippi, Med Ctr, Sch Med, Jackson, MS 39216 USA.
   [Karlson, Cynthia Windham] Univ Mississippi, Med Ctr, Dept Pediat, Div Hematol Oncol, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi Medical Center; University of Mississippi
RP DeMoss, P (corresponding author), Univ Mississippi, Med Ctr, Dept Pediat, Jackson, MS 39216 USA.
EM pdemoss@umc.edu
CR Alviar MJM, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006380.pub3
   Anghelescu DL, 2016, REHABIL ONCOL, V34, P104, DOI 10.1097/01.REO.0000000000000022
   [Anonymous], 2006, PRINCIPLES PRACTICE
   Barbin J, 2016, ANN PHYS REHABIL MED, V59, P270, DOI 10.1016/j.rehab.2016.04.001
   Bone M, 2002, REGION ANESTH PAIN M, V27, P481, DOI 10.1053/rapm.2002.35169
   Burgoyne LL, 2012, CLIN J PAIN, V28, P222, DOI 10.1097/AJP.0b013e318227ce7a
   Dinakar P, 2016, Bradley's neurology in clinical practice, V7th, P720
   Ferrari A, 2012, TUMORI J, V98, P399, DOI [10.1700/1053.11527, 10.1700/1146.12631]
   Ferraro F, 2016, EUR J PHYS REHAB MED, V52, P855
   Flor H, 2002, LANCET NEUROL, V1, P182, DOI 10.1016/S1474-4422(02)00074-1
   Gottschalk A, 2006, ANASTH INTENSIV NOTF, V41, P47, DOI 10.1055/s-2005-870254
   Hsu E, 2013, J PAIN RES, V6, P121, DOI 10.2147/JPR.S32299
   Huse E, 2001, PAIN, V90, P47, DOI 10.1016/S0304-3959(00)00385-7
   Ivani G, 2008, PEDIATR ANESTH, V18, P335, DOI 10.1111/j.1460-9592.2008.02444.x
   Poor Zamany Nejat Kermany,M, 2016, IRAN J CHILD NEUROL, V10, P42
   KRANE EJ, 1995, J PAIN SYMPTOM MANAG, V10, P21, DOI 10.1016/0885-3924(94)00062-P
   Kurath-Koller S, 2015, ACUPUNCT MED, V33, DOI 10.1136/acupmed-2014-010710
   Malavera-Angarita M.A., 2014, Revista Columbiana de Anesthesiologia, V42, P40, DOI [10.1016/j.rcae.2013.10.002, DOI 10.1016/J.RCAE.2013.10.002]
   McCormick Z, 2014, PAIN MED, V15, P292, DOI 10.1111/pme.12283
   Melzack R, 1997, BRAIN, V120, P1603, DOI 10.1093/brain/120.9.1603
   Nikolajsen L., 2013, WALL MELZACKS TXB PA, P915
   Nikolajsen L, 2013, PAIN MANAG, V3, P421, DOI [10.2217/PMT.13.51, 10.2217/pmt.13.51]
   Ramachandran VS, 2010, NEUROREPORT, V21, P727, DOI 10.1097/WNR.0b013e32833be9ab
   Ramsey LH, 2017, J PAIN SYMPTOM MANAG, V53, pE5, DOI 10.1016/j.jpainsymman.2017.02.003
   Robinson LR, 2004, ARCH PHYS MED REHAB, V85, P1, DOI 10.1016/S0003-9993(03)00476-3
   Rothgangel AS, 2011, INT J REHABIL RES, V34, P1, DOI 10.1097/MRR.0b013e3283441e98
   Rusy LM, 2001, J PAIN SYMPTOM MANAG, V21, P78, DOI 10.1016/S0885-3924(00)00243-8
   SIMMEL ML, 1962, J NEUROL NEUROSUR PS, V25, P69, DOI 10.1136/jnnp.25.1.69
   Smith DG, 2005, J REHABIL RES DEV, V42, P645, DOI 10.1682/JRRD.2005.05.0082
   SMITH J, 1995, MAYO CLIN PROC, V70, P357, DOI 10.4065/70.4.357
   Subedi B, 2011, PAIN RES TREAT, V2011, DOI 10.1155/2011/864605
   Thomas CR, 2003, BURNS, V29, P139, DOI 10.1016/S0305-4179(02)00281-4
   Wilder-Smith CH, 2005, ANESTHESIOLOGY, V103, P619, DOI 10.1097/00000542-200509000-00027
   Wilkins KL, 2004, CLIN J PAIN, V20, P293, DOI 10.1097/00002508-200409000-00003
   Wilkins KL, 1998, PAIN, V78, P7, DOI 10.1016/S0304-3959(98)00109-2
   Wolff A, 2011, PAIN PRACT, V11, P403, DOI 10.1111/j.1533-2500.2011.00454.x
   Wössner S, 2017, SCAND J PAIN, V17, P146, DOI 10.1016/j.sjpain.2017.09.001
NR 37
TC 22
Z9 25
U1 0
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD APR 9
PY 2018
VL 9
AR 219
DI 10.3389/fneur.2018.00219
PG 4
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GC0NU
UT WOS:000429475000001
PM 29686645
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Leed, R
   Bowman, MA
   Desai, K
   Bramble, M
   Armstrong, K
   Barg, F
AF Mao, Jun J.
   Leed, Rana
   Bowman, Marjorie A.
   Desai, Krupali
   Bramble, Manuel
   Armstrong, Katrina
   Barg, Frances
TI Acupuncture for Hot Flashes: Decision Making by Breast Cancer Survivors
SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE
LA English
DT Article
DE Acupuncture; Alternative Medicine; Behavior; Breast Cancer;
   Complementary Medicine; Hot Flashes; Survivors
ID RANDOMIZED CONTROLLED-TRIAL; ALTERNATIVE MEDICINE CAM; PRIMARY-CARE
   PHYSICIANS; MENOPAUSAL SYMPTOMS; VASOMOTOR SYMPTOMS; MEGESTROL-ACETATE;
   WEIGHT-GAIN; COMPLEMENTARY; WOMEN; MANAGEMENT
AB Purpose: Hot flashes (HFs) are a particularly common and distressing symptom among breast cancer survivors (BCSs). Given its low rate of side effects, acupuncture shows promise as a therapeutic approach for HFs, but little is known about BCS's decision making about the use of acupuncture. This study seeks to identify attitudes and beliefs about using acupuncture for HFs by BCSs.
   Methods: Using the Theory of Planned Behavior (TPB) as a conceptual framework, we conducted semistructured interviews among women with stage I-III breast cancer who had finished primary treatment and were currently experiencing HFs. Interviews were taped, transcribed, and coded. We used a modified grounded theory approach to analyze the data.
   Results: Twenty-five BCSs (13 whites/12 African American) participated in the study. Respondents stated that their intended use of acupuncture for HFs would be dependent on (1) expected therapeutic effects (eg, pain relief, energy); (2) practical concerns (eg, fear of needles, practitioner experience, time commitment); and (3) source of decision support/validation (eg, family members, physicians, self). Although constructs in the TPB accounted for many decision factors, respondents identified 2 major themes outside of the TPB: (1) viewing acupuncture as a natural alternative to medications, and (2) assessing the degree of HFs as bothersome enough in the context of other medical comorbidities to trigger the need for therapy.
   Conclusion: BCSs expressed varied expected therapeutic benefits, practical concerns, and decision support, emphasizing the "natural appeal" and symptom appraisal as key determinants when using acupuncture for HFs. Incorporating these factors in counseling BCSs may promote patient-centered communication, leading to improved hot flash management and quality of life. (J Am Board Fam Med 2012;25:323-332.)
C1 [Mao, Jun J.; Leed, Rana; Bowman, Marjorie A.; Desai, Krupali; Bramble, Manuel; Barg, Frances] Univ Penn, Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA.
   [Mao, Jun J.] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
   [Mao, Jun J.; Armstrong, Katrina] Univ Penn, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
   [Bowman, Marjorie A.] Univ Penn, Sch Med, Ctr Publ Hlth Initiat, Philadelphia, PA 19104 USA.
   [Armstrong, Katrina; Barg, Frances] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of Pennsylvania; University of Pennsylvania
RP Mao, JJ (corresponding author), Univ Penn, Sch Med, Dept Family Med & Community Hlth, 3400 Spruce St,2 Gates, Philadelphia, PA 19104 USA.
EM maoj@uphs.upenn.edu
RI Barg, Frances/E-1703-2017; bowman, marjorie/F-7235-2013; Mao,
   Jun/F-5009-2012
OI Barg, Frances/0000-0003-3328-1980; bowman, marjorie/0000-0002-1945-9212;
   
FU American Cancer Society [CCCDA-08-107-03]; National Institutes of Health
   [1K23 AT004112-04]
FX This project is supported in part by the American Cancer Society
   (CCCDA-08-107-03) and the National Institutes of Health (1K23
   AT004112-04).
CR AJZEN I, 1991, ORGAN BEHAV HUM DEC, V50, P179, DOI 10.1016/0749-5978(91)90020-T
   Balneaves LG, 2007, SUPPORT CARE CANCER, V15, P973, DOI 10.1007/s00520-007-0282-3
   Bertelli G, 2002, ANN ONCOL, V13, P883, DOI 10.1093/annonc/mdf151
   Boon H, 1999, QUAL HEALTH RES, V9, P639, DOI 10.1177/104973299129122135
   Boon Heather S, 2007, BMC Womens Health, V7, P4, DOI 10.1186/1472-6874-7-4
   Canales MK, 2003, FAM COMMUNITY HEALTH, V26, P11, DOI 10.1097/00003727-200301000-00003
   Carpenter Janet S, 2002, Oncol Nurs Forum, V29, pE16, DOI 10.1188/02.ONF.E16-E25
   Carpenter JS, 1998, CANCER-AM CANCER SOC, V82, P1682, DOI 10.1002/(SICI)1097-0142(19980501)82:9<1682::AID-CNCR14>3.0.CO;2-0
   Chalasani P, 2010, AM J MED, V123, P489, DOI 10.1016/j.amjmed.2009.09.042
   DiGiacomo SM, 1999, MED ANTHROPOL Q, V13, P436, DOI 10.1525/maq.1999.13.4.436
   Ganz PA, 2000, JNCI-J NATL CANCER I, V92, P1054, DOI 10.1093/jnci/92.13.1054
   Garro LC, 2000, ETHOS, V28, P275, DOI 10.1525/eth.2000.28.3.275
   Goddard G, 2005, J PAIN, V6, P237, DOI 10.1016/j.jpain.2004.12.009
   Godin G, 2007, BEHAV MED, V33, P67, DOI 10.3200/BMED.33.2.67-79
   Goodwin PJ, 1999, J CLIN ONCOL, V17, P120, DOI 10.1200/JCO.1999.17.1.120
   Greenlee H, 2009, BREAST CANCER RES TR, V117, P653, DOI 10.1007/s10549-009-0315-3
   Hervik J, 2009, BREAST CANCER RES TR, V116, P311, DOI 10.1007/s10549-008-0210-3
   Hirai K, 2008, ANN ONCOL, V19, P49, DOI 10.1093/annonc/mdm494
   Holmberg L, 2004, LANCET, V363, P453, DOI 10.1016/S0140-6736(04)15493-7
   Huang MI, 2006, FERTIL STERIL, V86, P700, DOI 10.1016/j.fertnstert.2006.02.100
   Kelly CM, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c693
   Kligman L, 2010, CURR ONCOL, V17, P81
   Kronenberg F, 2002, ANN INTERN MED, V137, P805, DOI 10.7326/0003-4819-137-10-200211190-00009
   LAU RR, 1997, HDB HLTH BEHAV RES, V1
   Lee MS, 2009, CLIMACTERIC, V12, P16, DOI 10.1080/13697130802566980
   Lee MS, 2009, BREAST CANCER RES TR, V115, P497, DOI 10.1007/s10549-008-0230-z
   Loprinzi Charles L, 2006, ACP J Club, V144, P41
   Loprinzi CL, 2000, LANCET, V356, P2059, DOI 10.1016/S0140-6736(00)03403-6
   LOPRINZI CL, 1994, NEW ENGL J MED, V331, P347, DOI 10.1056/NEJM199408113310602
   Mao JJ, 2009, J CLIN ONCOL, V27, P933, DOI 10.1200/JCO.2008.18.0679
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   Matsuyama H, 1998, J UROLOGY, V159, P2087, DOI 10.1016/S0022-5347(01)63262-2
   Nedstrand E, 2005, CLIMACTERIC, V8, P243, DOI 10.1080/13697130500118050
   Nelson HD, 2006, JAMA-J AM MED ASSOC, V295, P2057, DOI 10.1001/jama.295.17.2057
   Pandya KJ, 2005, LANCET, V366, P818, DOI 10.1016/S0140-6736(05)67215-7
   Pandya KJ, 2000, ANN INTERN MED, V132, P788, DOI 10.7326/0003-4819-132-10-200005160-00004
   Quella SK, 1998, CANCER, V82, P1784, DOI 10.1002/(SICI)1097-0142(19980501)82:9<1789::AID-CNCR27>3.0.CO;2-#
   Savard J, 2004, J PAIN SYMPTOM MANAG, V27, P513, DOI 10.1016/j.jpainsymman.2003.10.013
   Stearns V, 2005, J CLIN ONCOL, V23, P6919, DOI 10.1200/JCO.2005.10.081
   Stearns V, 2002, LANCET, V360, P1851, DOI 10.1016/S0140-6736(02)11774-0
   Stearns Vered, 2002, Curr Treat Options Oncol, V3, P179, DOI 10.1007/s11864-002-0064-6
   Su HI, 2010, BREAST CANCER RES TR, V124, P205, DOI 10.1007/s10549-010-0802-6
   Tchen N, 2003, J CLIN ONCOL, V21, P4175, DOI 10.1200/JCO.2003.01.119
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   Wong-Kim E, 2007, J HEALTH CARE POOR U, V18, P118, DOI 10.1353/hpu.2007.0123
NR 45
TC 21
Z9 26
U1 0
U2 12
PU AMER BOARD FAMILY MEDICINE
PI LEXINGTON
PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA
SN 1557-2625
J9 J AM BOARD FAM MED
JI J. Am. Board Fam. Med.
PD MAY-JUN
PY 2012
VL 25
IS 3
BP 323
EP 332
DI 10.3122/jabfm.2012.03.110165
PG 10
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 939KY
UT WOS:000303810600012
PM 22570396
OA Bronze
DA 2026-01-16
ER

PT J
AU Birch, S
   Lee, MS
   Alraek, T
   Kim, TH
AF Birch, Stephen
   Lee, Myeong Soo
   Alraek, Terje
   Kim, Tae-Hun
TI Overview of Treatment Guidelines and Clinical Practical Guidelines That
   Recommend the Use of Acupuncture: A Bibliometric Analysis
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review
DE clinical practice guideline; treatment guideline; acupuncture;
   systematic review; recommendation; snowballing method
ID TRADITIONAL CHINESE MEDICINE; POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED
   CONTROLLED-TRIALS; IRRITABLE-BOWEL-SYNDROME; INDIVIDUAL-PATIENT-DATA;
   IN-VITRO FERTILIZATION; CANCER-RELATED FATIGUE; QUALITY-OF-LIFE;
   LOW-BACK-PAIN; ALTERNATIVE MEDICINE
AB Introduction: As positive evidence emerges for the use of an intervention to treat a health problem, the intervention gradually becomes incorporated into treatment guidelines (TGs) or clinical practice guidelines (CPGs) that are related to that health problem. To assess whether this general hypothesis can apply to acupuncture, 96 health problems were identified for which positive conclusions in systematic reviews and meta-analyses regarding the effectiveness of acupuncture have been made and then searched for TGs or CPGs that have recommended the use of acupuncture. Methods: Through August 31, 2017, searches were performed in relevant medical databases and Google using treatment guideline, clinical practice guideline, and the names of the 96 medical conditions as search terms. A snow-balling search approach was adopted. All positive recommendations were added into the registry. Results: A total of 1311 publications were found that recommended using acupuncture published between 1991 and 2017. The number per year reached 50 in 2005 and 100 in 2009. In addition, 2189 positive recommendations were found for the use of acupuncture. Of these, 1486 were related to 107 pain indications and 703 were related to 97 nonpain indications. These recommendations were made by a wide range of groups, such as government health institutions, national guideline, and medical specialty groups. The recommendations came from around the world but were especially abundant in North America, Europe, and Australasia. Discussion and conclusion: Considerably more recommendations were found for the use of acupuncture than are known within the acupuncture or medical communities. A trend by year was also found; a rise in the number of positive statements about acupuncture was typically followed by a rise in the number of recommendations of acupuncture. Thus, the recommendations followed the emergent evidence for acupuncture. Better implementation plans need to be developed for the CPG/TG recommendations about acupuncture to be more effective/efficient.
C1 [Birch, Stephen; Alraek, Terje] Kristiania Univ Coll, Dept Hlth Sci, N-0107 Oslo, Norway.
   [Lee, Myeong Soo] Korea Inst Oriental Med, Clin Med Div, Daejeon, South Korea.
   [Alraek, Terje] UiT Arctic Univ Norway, Dept Community Med, Natl Res Ctr Complementary & Alternat Med, Fac Med, Tromso, Norway.
   [Kim, Tae-Hun] Kyung Hee Univ, Korean Med Hosp, Korean Med Clin Trial Ctr, Seoul, South Korea.
C3 Kristiania University College; Korea Institute of Oriental Medicine
   (KIOM); UiT The Arctic University of Tromso; Kyung Hee University; Kyung
   Hee University Hospital
RP Birch, S (corresponding author), Kristiania Univ Coll, Dept Hlth Sci, N-0107 Oslo, Norway.
EM sjbirch@gmail.com
RI Alræk, Terje/AAG-7001-2021; Lee, Myeong Soo/C-8147-2013
CR Aetna. Acupuncture, 2016, ACUPUNCTURE
   AL-Atiyyat N, 2017, INT J PALLIAT NURS, V23, P13, DOI 10.12968/ijpn.2017.23.1.13
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], ACUPUNCTURE MOXIBUST
   [Anonymous], 2014, EVID-BASED COMPL ALT, DOI DOI 10.1155/2014/850367
   [Anonymous], PAIN RELIEF
   [Anonymous], 2016, EVID-BASED COMPL ALT
   [Anonymous], AHRQ PUB
   [Anonymous], Acupuncture
   [Anonymous], EVID BASED COMPLEMEN
   [Anonymous], BMC COMPLEM ALTERN M
   Aquino CI, 2014, TRANSL MED UNISA, V9, P56
   Association of Gynecological Oncology, 2015, DIAGN TREATM PAT PRI
   Australian Government Department of Veterans' Affairs, 2010, ALT THER GOLD WHIT C
   Ba J, 2013, MED ACUPUNCT, V25, P317, DOI 10.1089/acu.2013.0968
   Bae K, 2015, INTEGR CANCER THER, V14, P496, DOI 10.1177/1534735415596573
   Bagley SM, 2014, ADDICT SCI CLIN PRAC, V9, DOI 10.1186/1940-0640-9-19
   Bai Y, 2014, J TRADIT CHIN MED, V34, P381, DOI 10.1016/S0254-6272(15)30037-6
   Bao YJ, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/170396
   Bardia A, 2006, J CLIN ONCOL, V24, P5457, DOI 10.1200/JCO.2006.08.3725
   Bennell KL, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e4934
   Berkshire Healthcare and NHS, 2012, BERKSH AD PALL CAR G
   Bezerra AG, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/563236
   Birch S, 2004, J ALTERN COMPLEM MED, V10, P468, DOI 10.1089/1075553041323894
   BMA British Medical Association Board of Science and Education., 2000, AC EFF SAF PRACT
   Borud E, 2010, AUTON NEUROSCI-BASIC, V157, P57, DOI 10.1016/j.autneu.2010.04.004
   Borud E, 2010, MATURITAS, V66, P131, DOI 10.1016/j.maturitas.2009.12.010
   Bosch P, 2015, EXPLORE-NY, V11, P281, DOI 10.1016/j.explore.2015.04.004
   Bower WF, 2010, AUTON NEUROSCI-BASIC, V157, P63, DOI 10.1016/j.autneu.2010.07.003
   Bower WF, 2005, NEUROUROL URODYNAM, V24, P267, DOI 10.1002/nau.20108
   Buchbinder R, 2008, CLIN EVID, V2008, P1117
   Cao H, 2013, EVID-BASED COMPL ALT, V2013
   Cao HJ, 2010, J ALTERN COMPLEM MED, V16, P397, DOI 10.1089/acm.2009.0599
   Cao HJ, 2009, J ALTERN COMPLEM MED, V15, P1171, DOI 10.1089/acm.2009.0041
   Cao L, 2012, SAUDI MED J, V33, P526
   Cassileth BR, 2016, ACUPUNCTURE DOES IT
   Chaillet N, 2014, BIRTH-ISS PERINAT C, V41, P122, DOI 10.1111/birt.12103
   Chan YY, 2015, J AFFECT DISORDERS, V176, P106, DOI 10.1016/j.jad.2015.01.048
   Chang SC, 2017, NEUROUROL URODYNAM, V36, P474, DOI 10.1002/nau.22958
   Chang WD, 2014, AM J CHINESE MED, V42, P1301, DOI 10.1142/S0192415X14500815
   Chao GQ, 2014, WORLD J GASTROENTERO, V20, P1871, DOI 10.3748/wjg.v20.i7.1871
   Chao LF, 2009, BREAST CANCER RES TR, V118, P255, DOI 10.1007/s10549-009-0533-8
   Chen HY, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-362
   Chen WK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056540
   Chen Y, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/956824
   Cheng XL, 2015, FRONT PHARMACOL, V6, DOI 10.3389/fphar.2015.00234
   Cheong KB, 2014, COMPLEMENT THER MED, V22, P767, DOI 10.1016/j.ctim.2014.05.002
   Cheong KB, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082474
   Cheong YC, 2008, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD006920.pub2, 10.1002/14651858.CD009526.pub2]
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Chiu HY, 2016, CANCER NURS, V39, P228, DOI 10.1097/NCC.0000000000000278
   Chiu HY, 2016, OBSTET GYNECOL, V127, P507, DOI 10.1097/AOG.0000000000001268
   Chiu HY, 2015, MENOPAUSE, V22, P234, DOI [10.1097/gme.0000000000000260, 10.1097/GME.0000000000000260]
   Cho HK, 2016, LARYNGOSCOPE, V126, P608, DOI 10.1002/lary.25721
   Cho SH, 2010, BJOG-INT J OBSTET GY, V117, P907, DOI 10.1111/j.1471-0528.2010.02570.x
   Cho SH, 2010, BJOG-INT J OBSTET GY, V117, P509, DOI 10.1111/j.1471-0528.2010.02489.x
   Cho SH, 2010, J OROFAC PAIN, V24, P152
   Cho SH, 2009, MENOPAUSE, V16, P1065, DOI 10.1097/gme.0b013e3181a48abd
   Cho YH, 2015, PAIN PRACT, V15, P279, DOI 10.1111/papr.12208
   Choi TY, 2017, INTEGR CANCER THER, V16, P135, DOI 10.1177/1534735416664172
   Chou R, 2007, ANN INTERN MED, V147, P478, DOI 10.7326/0003-4819-147-7-200710020-00006
   Chou R, 2017, ANN INTERN MED, V166, P493, DOI 10.7326/M16-2459
   Chung YC, 2012, COMPLEMENT THER MED, V20, P353, DOI 10.1016/j.ctim.2012.02.008
   Clauw DJ, 2014, JAMA-J AM MED ASSOC, V311, P1547, DOI 10.1001/jama.2014.3266
   Close C, 2014, J ADV NURS, V70, P1702, DOI 10.1111/jan.12360
   Cohen JM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041941
   Cooper K, 2017, SEX MED-UK, V5, pE1, DOI 10.1016/j.esxm.2016.08.002
   Corbett MS, 2013, OSTEOARTHR CARTILAGE, V21, P1290, DOI 10.1016/j.joca.2013.05.007
   Cox J, 2016, J ORTHOP SPORT PHYS, V46, P409, DOI 10.2519/jospt.2016.6270
   Coyle M, 2014, ALTERN THER HEALTH M, V20, P10
   Cunningham Sheila, 2011, Nurs Stand, V25, P39
   Daneshkazemi Alireza, 2016, Anesth Essays Res, V10, P173, DOI [10.4103/0259-1162.177182, 10.4103/0259-1162.177182]
   Deare JC, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007070.pub2
   Deng M, 2016, ACUPUNCT MED, V34, P342, DOI 10.1136/acupmed-2015-010989
   Dimitrova A, 2015, NEUROLOGY SP3, V84, P306
   Dimitrova A, 2017, J ALTERN COMPLEM MED, V23, P164, DOI 10.1089/acm.2016.0155
   Dong W, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000510
   Dos Santos S, 2010, MED ACUPUNCT, V22, P81, DOI 10.1089/acu.2009.0730
   Dune LS, 2006, EXPLORE-NY, V2, P314, DOI 10.1016/j.explore.2006.04.004
   DVAAG Department of Veterans' Affairs Australian Government., 2013, EV COMP TECHN REP WH
   Edwards L, 2016, NEONATAL NETW, V35, P305, DOI 10.1891/0730-0832.35.5.305
   Ee CC, 2008, AM J OBSTET GYNECOL, V198, P254, DOI 10.1016/j.ajog.2007.11.008
   ERNST E, 1999, ACUPUNCTURE SCI APPR, P107
   Ernst Edzard, 2010, J Pain Symptom Manage, V40, pe3, DOI 10.1016/j.jpainsymman.2010.03.010
   Ernst E, 2010, RHEUMATOLOGY, V49, P1957, DOI 10.1093/rheumatology/keq180
   Ernst E, 2009, J PAIN SYMPTOM MANAG, V37, P709, DOI 10.1016/j.jpainsymman.2008.04.009
   European Partnership for Action Against Cancer ( EPAAC), 2014, D5 COMPL ALT MED CAM
   Ezzo J, 2001, ARTHRITIS RHEUM, V44, P819, DOI 10.1002/1529-0131(200104)44:4<819::AID-ANR138>3.3.CO;2-G
   Fan Lin-Lin, 2014, Zhen Ci Yan Jiu, V39, P156
   Feng SY, 2015, AM J RHINOL ALLERGY, V29, P57, DOI 10.2500/ajra.2015.29.4116
   Frisk JW, 2014, SUPPORT CARE CANCER, V22, P1409, DOI 10.1007/s00520-014-2126-2
   Fu LM, 2009, J ALTERN COMPLEM MED, V15, P133, DOI 10.1089/acm.2008.0135
   Furlan AD, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001351.pub2
   Furlan AD, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/953139
   Furness S, 2013, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD009603.pub3, 10.1002/14651858.CD009603.pub2]
   Gadau M, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-136
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Glazener CMA, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005230
   Goldie L, 2016, EMERG MED J, V33, P743, DOI 10.1136/emermed-2016-206204.2
   Grant S, 2018, J TRAUMA DISSOCIATIO, V19, P39, DOI 10.1080/15299732.2017.1289493
   Green S, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005319
   Gutke A, 2015, ACTA OBSTET GYN SCAN, V94, P1156, DOI 10.1111/aogs.12681
   Haefner Hope K, 2005, J Low Genit Tract Dis, V9, P40, DOI 10.1097/00128360-200501000-00009
   Han GJ, 2016, GASTROENTEROLOGY, V150, pS928, DOI 10.1016/S0016-5085(16)33145-6
   Hanchanale S, 2015, SUPPORT CARE CANCER, V23, P881, DOI 10.1007/s00520-014-2477-8
   He XR, 2013, ASIAN PAC J CANCER P, V14, P3067, DOI 10.7314/APJCP.2013.14.5.3067
   Hempel S., 2013, Project #05-226
   Hopton A, 2010, PAIN PRACT, V10, P94, DOI 10.1111/j.1533-2500.2009.00337.x
   Hou Pu-Wei, 2015, J Tradit Complement Med, V5, P182, DOI [10.1016/j.jtcme.2015.06.002, 10.1016/j.jtcme.2015.06.002]
   Hu CQ, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1720239
   Huang T, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005230.pub2
   Hutchinson AJP, 2012, J ORTHOP SURG RES, V7, DOI 10.1186/1749-799X-7-36
   Ji M, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/192808
   Jiin Kim, 2016, [Journal of Acupuncture and Tuina Science, 针灸推拿医学], V14, P257, DOI 10.1007/s11726-016-0934-2
   Jo J, 2017, ACUPUNCT MED, V35, P162, DOI 10.1136/acupmed-2016-011163
   Johns C, 2016, BREAST CANCER RES TR, V156, P415, DOI 10.1007/s10549-016-3765-4
   Jones L, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009234.pub2
   Jueckstock JK, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-46
   Jung A, 2011, J DENT, V39, P341, DOI 10.1016/j.jdent.2011.02.006
   Kang HS, 2011, MATURITAS, V68, P346, DOI 10.1016/j.maturitas.2011.02.001
   Kannan P, 2014, J PHYSIOTHER, V60, P13, DOI 10.1016/j.jphys.2013.12.003
   Keller A, 2007, EUR SPINE J, V16, P1776, DOI 10.1007/s00586-007-0379-x
   Kiddoo D., 2015, BMJ CLIN EVID, V2015, P0305
   Kim KN, 2015, COMPLEMENT THER MED, V23, P759, DOI 10.1016/j.ctim.2015.07.007
   Kim KH, 2016, ACUPUNCT MED, V34, P248, DOI 10.1136/acupmed-2015-010941
   Kim Young-Dae, 2013, Evid Based Complement Alternat Med, V2013, P615857, DOI 10.1155/2013/615857
   Kong JC, 2010, CAN MED ASSOC J, V182, P1723, DOI 10.1503/cmaj.091113
   Kopf A., 2010, Guide to pain management in low resource settings
   Kwon YD, 2006, RHEUMATOLOGY, V45, P1331, DOI 10.1093/rheumatology/kel207
   La Touche R, 2010, CLIN J PAIN, V26, P541, DOI 10.1097/AJP.0b013e3181e2697e
   Lau CHY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002901
   Leaver AM, 2010, J PHYSIOTHER, V56, P73, DOI 10.1016/S1836-9553(10)70037-0
   Lee A, 2011, COCHRANE DATABAS SYS, V2
   Lee A, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003281.pub4
   Lee C, 2012, SYST REV, V1, DOI 10.1186/2046-4053-1-46
   Lee H, 2004, GASTROINTEST ENDOSC, V60, P784, DOI 10.1016/S0016-5107(04)02030-9
   Lee H, 2004, AM J OBSTET GYNECOL, V191, P1573, DOI 10.1016/j.ajog.2004.05.027
   Lee J, 2015, INT J STROKE, V10, P172
   Lee MS, 2008, RHEUMATOLOGY, V47, P1747, DOI 10.1093/rheumatology/ken330
   Lee MS, 2011, CHIN J INTEGR MED, V17, P187, DOI 10.1007/s11655-011-0665-7
   Lee MS, 2009, BJU INT, V104, P366, DOI 10.1111/j.1464-410X.2009.08422.x
   Lee Sang-Hun, 2011, Curr Urol Rep, V12, P288, DOI 10.1007/s11934-011-0186-0
   Lee SH, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006901
   Lee SJ, 2013, EUR J INTEGR MED, V5, P87, DOI 10.1016/j.eujim.2012.10.006
   Lewis R, 2011, HEALTH TECHNOL ASSES, V15, P1, DOI 10.3310/hta15390
   Lewis RA, 2015, SPINE J, V15, P1461, DOI 10.1016/j.spinee.2013.08.049
   Li CY, 2015, WORLD J GASTROENTERO, V21, P2315, DOI 10.3748/wjg.v21.i8.2315
   Li J, 2016, AFR J TRADIT COMPLEM, V13
   Li L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114057
   Li Lun, 2016, Asian Pac J Cancer Prev, V17, P4875
   Li PP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121880
   Lian WL, 2014, CHIN J INTEGR MED, V20, P136, DOI 10.1007/s11655-013-1439-1
   Liddle SD, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001139.pub4
   Lim B, 2006, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD005111, 10.1002/14651858.CD005111.pub3]
   Lim SM, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/870398
   Lin LW, 2009, J ALTERN COMPLEM MED, V15, P1335, DOI 10.1089/acm.2008.0373
   Linde K, 2001, BMC Complement Altern Med, V1, P4, DOI 10.1186/1472-6882-1-4
   Linde K, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001218.pub3
   Linde K, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007587.pub2
   Linde K, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001218.pub2
   Ling WM, 2014, ONCOL NURS FORUM, V41, P581, DOI 10.1188/14.ONF.581-592
   List T, 2010, J ORAL REHABIL, V37, P430, DOI 10.1111/j.1365-2842.2010.02089.x
   Liu BP, 2016, INT UROL NEPHROL, V48, P1977, DOI 10.1007/s11255-016-1403-z
   Liu F, 2014, J ALTERN COMPLEM MED, V20, P535, DOI 10.1089/acm.2013.0364
   Liu FY, 2016, EUR ARCH OTO-RHINO-L, V273, P285, DOI 10.1007/s00405-014-3341-7
   Liu Lizhou, 2015, Evid Based Complement Alternat Med, V2015, P328196, DOI 10.1155/2015/328196
   LOPES LC, 2016, REV LAT AM ENFERM, V24
   Lovelace TL, 2014, OR SURG OR MED OR PA, V117, P595, DOI 10.1016/j.oooo.2014.01.229
   Lu ZT, 2015, EVID-BASED COMPL ALT, V2015
   Ludwig Boltzmann Institute Health Technology Assessment, 2014, AC FIELDS APPL EV SE
   Lund I, 2016, J PAIN RES, V9, P157, DOI 10.2147/JPR.S55580
   Ma C, 2015, J ALTERN COMPLEM MED, V21, P520, DOI 10.1089/acm.2014.0274
   Ma R, 2014, J Psychol Psychother, V5, P155
   Malaysian Association for the Study of Pain, 2009, MAL LOW BACK PAIN MA
   Mangesi L, 2016, COCHRANE DATABAS SYS, V6
   Manheimer E, 2005, ANN INTERN MED, V142, P651, DOI 10.7326/0003-4819-142-8-200504190-00014
   Manheimer E, 2011, COCHRANE DATABAS SYS, V1
   Mannix SM, 2013, MED ACUPUNCT, V25, P23, DOI 10.1089/acu.2012.0928
   Manyande A, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006447.pub3
   Manyanga T, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-312
   Matthews A, 2010, COCHRANE DB SYST REV, V9
   McDonald J., 2017, The Acupuncture Evidence Project: A Comparative Literature Review (Revised Edition)
   McKeon C., 2013, AJACM, V8, P2
   Monckton J, 1998, FINAL REPORT OF THE, P49
   Myers CD, 2002, J AM DENT ASSOC, V133, P1189
   Nahin RL, 2016, MAYO CLIN PROC, V91, P1292, DOI 10.1016/j.mayocp.2016.06.007
   National Cancer Institute at the National Institutes of Health (NIH), 2017, PAIN PEOPL CANC
   National Institute for Health and Care Excellence (NICE), 2015, HEAD 12S DIAGN MAN
   Nematian-Semani M, 2015, GLOBAL ATLAS ALLERGI
   NHS National Institute for Clinical Excellence. Guidance on Cancer Services: Improving Supportive and Palliative Care for Adults with Cancer, 2004, GUID CANC SERV IMPR
   Nunley Christy, 2008, J Perianesth Nurs, V23, P247, DOI 10.1016/j.jopan.2008.05.001
   Olivera CK, 2016, AM J OBSTET GYNECOL, V215, P34, DOI 10.1016/j.ajog.2016.01.156
   Oregon Health Authority, 2013, PRIOR HLTH SERV REP
   Pang B, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/3862916
   Park J, 2012, J AM GERIATR SOC, V60, P555, DOI 10.1111/j.1532-5415.2011.03846.x
   Pei Li-Xia, 2012, Zhongguo Zhen Jiu, V32, P957
   Peng Hao, 2010, Zhong Xi Yi Jie He Xue Bao, V8, P501
   Pettersson PH, 2012, J CLIN NURS, V21, P1799, DOI 10.1111/j.1365-2702.2012.04114.x
   Pfab F, 2014, EXPERT REV CLIN IMMU, V10, P831, DOI 10.1586/1744666X.2014.924855
   Pilkington Karen, 2007, Acupunct Med, V25, P1
   POCKET Physicians of Ontario Collaborating for Knowledge Exchange and Transfer, 2009, EV SUMM MAN NONSP CH
   Poder Thomas G, 2013, Glob J Health Sci, V6, P112, DOI 10.5539/gjhs.v6n2p112
   Posadzki P, 2011, J ANDROL, V33, P15, DOI 10.2164/jandrol.111.013235
   Qin ZS, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/425108
   Qin ZS, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003095
   Quan XH, 2015, 2015 7TH INTERNATIONAL CONFERENCE ON INFORMATION TECHNOLOGY IN MEDICINE AND EDUCATION (ITME), P32, DOI 10.1109/ITME.2015.52
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Ren Li-Na, 2014, Zhen Ci Yan Jiu, V39, P238
   Republic of Rwanda Ministry of Health, 2012, PAIN MAN GUID
   Richardson MA, 2001, ALTERNAT THER HEALTH, V7, pS28
   Riley RR, 2011, HAEMOPHILIA, V17, P839, DOI 10.1111/j.1365-2516.2011.02567.x
   Roberts J, 2007, 59 DEP PUBL HLTH EP
   Roberts J, 2007, AVHRR LEVEL 1B DATA, P1
   Rosted P, 1998, Oral Dis, V4, P100
   Ruan ZZ, 2016, INT J CLIN EXP MED, V9, P1772
   Rubinstein SM, 2010, EUR SPINE J, V19, P1213, DOI 10.1007/s00586-010-1356-3
   Saramago P, 2016, BMC MED RES METHODOL, V16, DOI 10.1186/s12874-016-0224-1
   Savino F, 2014, ITAL J PEDIATR, V40, DOI 10.1186/1824-7288-40-53
   Selfe TK, 2008, FAM COMMUNITY HEALTH, V31, P247, DOI 10.1097/01.FCH.0000324482.78577.0f
   Olid AS, 2013, MED ACUPUNCT, V25, P386, DOI 10.1089/acu.2013.0976
   Shen CJ, 2015, GYNECOL OBSTET INVES, V79, P1, DOI 10.1159/000362231
   Shengelia R, 2013, PAIN MANAG NURS, V14, pE274, DOI 10.1016/j.pmn.2012.01.001
   Shergis JL, 2016, COMPLEMENT THER MED, V26, P11, DOI 10.1016/j.ctim.2016.02.007
   Shim JW, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/3485875
   Shin HC, 2016, LARYNGOSCOPE, V126, P1761, DOI 10.1002/lary.25883
   Shin NY, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/7823278
   Smith CA, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004046.pub3
   Sniezek DP, 2013, MED ACUPUNCT, V25, P164, DOI 10.1089/acu.2012.0900
   Southern C, 2016, CHIN MED-UK, V11, DOI 10.1186/s13020-016-0119-4
   Standish LJ, 2008, AM J HOSP PALLIAT ME, V25, P298, DOI 10.1177/1049909108315916
   Stones RW, 2005, BRIT MED J, V331, P249, DOI 10.1136/bmj.331.7511.249
   Streitberger K, 2006, AUTON NEUROSCI-BASIC, V129, P107, DOI 10.1016/j.autneu.2006.07.015
   Stub T, 2011, EUR J INTEGR MED, V3, pe259
   Sun Y, 2008, BRIT J ANAESTH, V101, P151, DOI 10.1093/bja/aen146
   [孙燕丽 SUN Yanli], 2008, [中国循证医学杂志, Chinese Journal of Evidence-Based Medicine], V8, P340
   Sun Y, 2008, ANESTH ANALG, V107, P2038, DOI 10.1213/ane.0b013e318187c76a
   Tahiri M, 2012, AM J MED, V125, P576, DOI 10.1016/j.amjmed.2011.09.028
   Tait PL., 2002, Acupuncture: Evidence from Systematic Reviews and Meta-analyses
   Tao WW, 2015, ONCOTARGET, V6, P39725, DOI 10.18632/oncotarget.5388
   Taylor-Swanson L, 2015, CLIMACTERIC, V18, P142, DOI 10.3109/13697137.2014.937687
   Tedesco D, 2017, JAMA SURG, V152, DOI 10.1001/jamasurg.2017.2872
   The Chiropractic Resource Organization, 1999, LOW BACK PAIN FREQ M
   The CSP, 2014, PHYS WORKS CHRON PAI
   The New Zealand Government Accident Compensation Corporation., 2014, AC TREATM TRIGG
   Trigkilidas D, 2010, ANN ROY COLL SURG, V92, P595, DOI 10.1308/003588410X12699663904196
   Trinh K., 2016, COCHRANE DB SYST REV, V5, DOI DOI 10.1002/14651858.CD004870.PUB4
   Trinh K, 2007, SPINE, V32, P236, DOI 10.1097/01.brs.0000252100.61002.d4
   Trinh KV, 2004, RHEUMATOLOGY, V43, P1085, DOI 10.1093/rheumatology/keh247
   Tsai MY, 2014, ACUPUNCT MED, V32, P406, DOI 10.1136/acupmed-2014-010592
   Tsao JCI, 2006, BRINGING PAIN RELIEF TO CHILDREN: TREATMENT APPROACHES, P131, DOI 10.1007/978-1-59745-125-3_6
   Turner KC, 2013, J ACUP ASSOC CHARTER, P21
   Vados L, 2015, ACUPUNCT MED, V33, P180, DOI 10.1136/acupmed-2014-010705
   van Tulder MW, 2005, BEST PRACT RES CL RH, V19, P639, DOI 10.1016/j.berh.2005.03.006
   Verghese TS, 2016, INT UROGYNECOL J, V27, P1127, DOI 10.1007/s00192-015-2886-3
   Vickers A, 2002, QUAL SAF HEALTH CARE, V11, P92, DOI 10.1136/qhc.11.1.92
   Vickers AJ, 1996, J ROY SOC MED, V89, P303, DOI 10.1177/014107689608900602
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Vieira BL, 2016, AM J CLIN DERMATOL, V17, P557, DOI 10.1007/s40257-016-0209-1
   Vleeming A, 2008, EUR SPINE J, V17, P794, DOI 10.1007/s00586-008-0602-4
   Wahbeh H, 2014, J EVID-BASED INTEGR, V19, P161, DOI 10.1177/2156587214525403
   Wang H, 2008, J AFFECT DISORDERS, V111, P125, DOI 10.1016/j.jad.2008.04.020
   Wang J, 2016, EVID-BASED COMPL ALT, V2016
   Wang LZ, 2013, ACUPUNCTURE MODERN M
   Wang XJ, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/396396
   Wang YY, 2014, COMPLEMENT THER MED, V22, P826, DOI 10.1016/j.ctim.2014.06.004
   Wegrzyniak Lindsey J, 2012, Rev Obstet Gynecol, V5, P78
   Williams Jr JW, 2011, 09010 VAESP DEP VET
   Wu JM, 2012, CAN J PSYCHIAT, V57, P397, DOI 10.1177/070674371205700702
   Wu MS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150367
   Wu P, 2010, STROKE, V41, pE171, DOI 10.1161/STROKEAHA.109.573576
   Wu XL, 2015, SCI REP-UK, V5, DOI [10.1038/srep11728, 10.1038/srep16776]
   Xiao Li, 2009, Zhongguo Zhen Jiu, V29, P512
   [熊俊 XIONG Jun], 2009, [中国循证医学杂志, Chinese Journal of Evidence-Based Medicine], V9, P969
   Xu M, 2013, AM J CHINESE MED, V41, P1, DOI 10.1142/S0192415X13500018
   Yang A, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004131.pub3
   Yang L, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/143858
   Yang Y, 2016, ACUPUNCT MED, V34, P76, DOI 10.1136/acupmed-2015-010903
   Yao Q, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/5191729
   Yeh CH, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/934670
   Yeung WF, 2009, SLEEP MED, V10, P694, DOI 10.1016/j.sleep.2008.08.012
   Yin C, 2017, CURR OPIN ANESTHESIO, V30, P583, DOI 10.1097/ACO.0000000000000501
   Yoo JE, 2015, FORSCH KOMPLEMENTMED, V22, P111, DOI 10.1159/000381360
   Young G, 2002, COCHRANE DB SYST REV, V1
   Yu C, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/208690
   Yuan QL, 2016, SCI REP-UK, V6, DOI 10.1038/srep30675
   Yuan Q, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130209
   Yue JH, 2017, ACUPUNCT MED, V35, DOI 10.1136/acupmed-2015-011024
   Zeng YC, 2015, EUR J INTEGR MED, V7, P94, DOI 10.1016/j.eujim.2014.11.001
   Zeng YC, 2014, INTEGR CANCER THER, V13, P193, DOI 10.1177/1534735413510024
   Zhang GX, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118498
   Zhang JP, 2014, NEURAL REGEN RES, V9, P773, DOI 10.4103/1673-5374.131590
   Zhang JH, 2014, NEUROEPIDEMIOLOGY, V42, P50, DOI 10.1159/000355435
   Zhang RQ, 2017, POSTGRAD MED J, V93, P743, DOI 10.1136/postgradmedj-2017-134969
   Zhang T, 2013, AM J CHINESE MED, V41, P717, DOI 10.1142/S0192415X13500493
   Zhang XY, 2015, SCI REP-UK, V5, DOI 10.1038/srep10559
   Zhang Y, 2016, J ALTERN COMPLEM MED, V22, P1, DOI 10.1089/acm.2015.0114
   Zhang ZJ, 2010, J AFFECT DISORDERS, V124, P9, DOI 10.1016/j.jad.2009.07.005
   Zhao XF, 2012, TOP STROKE REHABIL, V19, P226, DOI 10.1310/tsr1903-226
   Zhao XF, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127019
   Zheng CH, 2012, ALTERNAT MED, V2012
   Zheng CH, 2012, FERTIL STERIL, V97, P599, DOI 10.1016/j.fertnstert.2011.12.007
   Zhou J, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000933
   Zhou WM, 2016, J ALTERN COMPLEM MED, V22, P380, DOI 10.1089/acm.2014.0400
   [朱丽凌 Zhu Liling], 2011, [中国循证医学杂志, Chinese Journal of Evidence-Based Medicine], V11, P325
   Zhuang LP, 2013, INTEGR CANCER THER, V12, P197, DOI 10.1177/1534735412451321
NR 306
TC 60
Z9 75
U1 1
U2 40
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD AUG
PY 2018
VL 24
IS 8
BP 752
EP 769
DI 10.1089/acm.2018.0092
EA JUN 2018
PG 18
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA GQ7KY
UT WOS:000435549600001
PM 29912569
DA 2026-01-16
ER

PT J
AU Pérez, C
   Quintanar, T
   García, C
   Cuervo, MA
   Goberna, MJ
   Monleón, M
   González, AI
   Lizán, L
   Comellas, M
   Alvarez, M
   Peña, I
AF Perez, Concha
   Quintanar, Teresa
   Garcia, Carmen
   Cuervo, Miguel Angel
   Goberna, Maria Jesus
   Monleon, Manuela
   Gonzalez, Ana I.
   Lizan, Luis
   Comellas, Marta
   Alvarez, Maria
   Pena, Isaac
TI Cancer-Related Pain Management in Suitable Intrathecal Therapy
   Candidates: A Spanish Multidisciplinary Expert Consensus
SO CURRENT ONCOLOGY
LA English
DT Article
DE intrathecal; cancer; pain; Delphi technique; consensus
ID GUIDELINES; ANALGESIA
AB A consensus is needed among healthcare professionals involved in easing oncological pain in patients who are suitable candidates for intrathecal therapy. A Delphi consultation was conducted, guided by a multidisciplinary scientific committee. The 18-item study questionnaire was designed based on a literature review together with a discussion group. The first-round questionnaire assessed experts' opinion of the current general practice, as well as their recommendation and treatment feasibility in the near future (2-3-year period) using a 9-point Likert scale. Items for which consensus was not achieved were included in a second round. Consensus was defined as & GE;75% agreement (1-3 or 7-9). A total of 67 panelists (response rate: 63.2%) and 62 (92.5%) answered the first and second Delphi rounds, respectively. The participants were healthcare professionals from multiple medical disciplines who had an average of 17.6 (7.8) years of professional experience. A consensus was achieved on the recommendations (100%). The actions considered feasible to implement in the short term included effective multidisciplinary coordination, improvement in communication among the parties, and an assessment of patient satisfaction. Efforts should focus on overcoming the barriers identified, eventually leading to the provision of more comprehensive care and consideration of the patient's perspective.
C1 [Perez, Concha] Hosp Univ Princesa, Madrid 28006, Spain.
   [Quintanar, Teresa] Hosp Gen Univ Elche, Elche 03203, Spain.
   [Garcia, Carmen] Serv Madrileno Salud, Unidad Continu Asistencial, Madrid 28046, Spain.
   [Cuervo, Miguel Angel] Hosp Univ Badajoz, Badejoz 06080, Spain.
   [Goberna, Maria Jesus] Complejo Hosp Univ Vigo, Vigo 36204, Spain.
   [Monleon, Manuela] Equipo Soporte Atenc Domiciliaria Legazpi, Madrid 28045, Spain.
   [Gonzalez, Ana I.] Asociac Espanola Canc AECC, Madrid 28045, Spain.
   [Lizan, Luis; Comellas, Marta] Univ Jaume 1, Dept Med, Outcomes 10, Castellon de La Plana 12071, Spain.
   [Alvarez, Maria] Medtron Iber SA, Hlth Econ & Outcomes Res Unit, Madrid 28050, Spain.
   [Pena, Isaac] Hosp Univ Virgen Rocio, Seville 41013, Spain.
C3 Hospital de La Princesa; Complexo Hospitalario Universitario de Vigo;
   Universitat Jaume I; Virgen del Rocio University Hospital
RP Pérez, C (corresponding author), Hosp Univ Princesa, Madrid 28006, Spain.
EM concha.phte@gmail.com; teresaqv22@yahoo.es; cubero@salud.madrid.org;
   miguelangel.cuervop@gmail.com; maria.jesus.goberna.iglesias@sergas.es;
   manuela.monleon@salud.madrid.org; ana.gonzalez@contraelcancer.es;
   lizan@outcomes10.com; mcomellas@outcomes10.com;
   maria.alvarez.orozco@medtronic.com; isaacpv@gmail.com
OI Pérez hernández, Concepción/0000-0001-5220-8936; Cuervo Pinna, Miguel
   Ángel/0000-0001-8613-7072; Comellas, Marta/0000-0002-5275-9882;
   Quintanar, Teresa/0000-0001-5259-9447
FU Medtronic Iberica S.A
FX This research was funded by Medtronic Iberica S.A
CR Adler JA, 2017, J PAIN RES, V10, P2565, DOI 10.2147/JPR.S142147
   [Anonymous], 2018, WHO guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents
   Bolash R, 2014, NEUROSURG CLIN N AM, V25, P735, DOI 10.1016/j.nec.2014.06.006
   Bruel BM, 2016, PAIN MED, V17, P2404, DOI 10.1093/pm/pnw060
   Cañete JD, 2020, J RHEUMATOL, V47, P1637, DOI 10.3899/jrheum.191056
   Carr D, 2002, Evid Rep Technol Assess (Summ), P1
   Casado E, 2021, ARCH OSTEOPOROS, V16, DOI 10.1007/s11657-021-00878-w
   Deer TR, 2011, PAIN PHYSICIAN, V14, pE283
   Escobar Y, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-26753-3
   FINK A, 1984, AM J PUBLIC HEALTH, V74, P979, DOI 10.2105/AJPH.74.9.979
   García-Mata J, 2018, CLIN TRANSL ONCOL, V20, P1061, DOI 10.1007/s12094-017-1826-8
   Gulati A, 2014, CURR PAIN HEADACHE R, V18, DOI 10.1007/s11916-013-0391-2
   Hochberg U, 2020, PAIN PHYSICIAN, V23, pE451, DOI 10.36076/ppj.2020/23/e451
   Jara C, 2018, CLIN TRANSL ONCOL, V20, P97, DOI 10.1007/s12094-017-1791-2
   Kurita GP, 2019, CANCERS, V11, DOI 10.3390/cancers11040443
   Liu HJ, 2017, AM J HOSP PALLIAT ME, V34, P148, DOI 10.1177/1049909115615110
   Mercadante S, 2019, CANCERS, V11, DOI 10.3390/cancers11040565
   Nagel SJ, 2018, NEUROMODULATION, V21, P625, DOI 10.1111/ner.12693
   Olmos-Jiménez R, 2017, FARM HOSP, V41, P611, DOI 10.7399/fh.10762
   Perez C., 2017, GADO GUIA ABORDAJE I
   Porta-Sales J, 2015, J PALLIAT MED, V18, P923, DOI 10.1089/jpm.2015.29002.jps
   Samuelly-Leichtag G, 2019, RAMBAM MAIMONIDES ME, V10, DOI 10.5041/RMMJ.10369
   Shah R, 2015, CURR PAIN HEADACHE R, V19, DOI 10.1007/s11916-015-0488-x
   Shaparin N, 2015, J FAM PRACTICE, V64, P166
   Silverman JE, 2018, PAIN MANAG, V8, P389, DOI 10.2217/pmt-2018-0022
   Snijders RAH, 2023, CANCERS, V15, DOI 10.3390/cancers15030591
   Wang NN, 2022, BMC HEALTH SERV RES, V22, DOI 10.1186/s12913-022-08610-1
   Yin YN, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000022448
NR 28
TC 1
Z9 2
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1198-0052
EI 1718-7729
J9 CURR ONCOL
JI Curr. Oncol.
PD AUG
PY 2023
VL 30
IS 8
BP 7303
EP 7314
DI 10.3390/curroncol30080530
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA Q0PA3
UT WOS:001054608200001
PM 37623011
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ji, L
   Han, L
   Sharma, A
AF Ji, Lei
   Han, Lin
   Sharma, Aabha
TI Efficacy of acupuncture in managing radiotherapy/chemotherapy-induced
   oral mucositis: a systematic review and meta-analysis
SO SUPPORTIVE CARE IN CANCER
LA English
DT Review
DE Oral mucositis; Radiotherapy; Chemotherapy; Acupuncture; Cancer;
   Meta-analysis
ID CHEMOTHERAPY; RADIOTHERAPY; MANAGEMENT; CANCER
AB Purpose To evaluate the preventive and therapeutic efficacy of acupuncture modalities in radiation/chemotherapy-induced oral mucositis (RIOM/CIOM) management through evidence synthesis. Methods A systematic search was performed in eight biomedical databases: four English-language databases (PubMed, Embase, Web of Science, and Cochrane Library) and four Chinese-language databases (China National Knowledge Infrastructure (CNKI), Wanfang, VIP, and SinoMed) for studies published up to July 25, 2025. Randomized controlled trials (RCTs) in English or Chinese investigating acupuncture for RIOM/CIOM were included. Dual independent extraction with standardized forms and quality appraisal using the Cochrane RoB 2.0 tool were implemented. The primary outcome was OM grading according to WHO, RTOG, or other recognized scales. The evidence quality was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. Results Eleven RCTs (n = 865) were included. Acupuncture significantly reduced moderate-to-severe OM incidence [RR = 0.58, 95% CI:0.45-0.76; P < 0.0001), with therapeutic interventions showing greater efficacy than preventive approaches (P < 0.0001). Auricular acupuncture showed substantial benefit (RR = 0.54 vs manual technique RR = 0.97). Other outcomes revealed significant ulcer duration reduction (SMD = -1.13, 95% CI -1.71-[-0.55]; P = 0.0001), pain score improvement (SMD = -1.89, P = 0.0005), and enhanced immune modulation (TGF-beta 1/IL-6 levels) with Karnofsky performance increase (MD = 5.83, P = 0.004). No severe adverse events were reported. The quality of evidence was rated as moderate due to significant heterogeneity observed across the studies. Conclusions The systematic review and meta-analysis found that acupuncture was effectively associated with preventing and treating RIOM/CIOM, shortening ulcer duration, reducing ulcer size, alleviating pain, and improving quality of life, although the evidence level was moderate. The finding suggests that more high-quality RCTs were needed for validation.
C1 [Ji, Lei; Han, Lin; Sharma, Aabha] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China.
   [Ji, Lei; Han, Lin; Sharma, Aabha] Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin, Peoples R China.
   [Ji, Lei; Sharma, Aabha] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine
RP Han, L (corresponding author), Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China.; Han, L (corresponding author), Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin, Peoples R China.
EM tjhanlin@163.com
CR Aghamohammadi A, 2018, CLIN ORAL INVEST, V22, P2263, DOI 10.1007/s00784-017-2324-7
   Anderson C, 2025, SEMIN RADIAT ONCOL, V35, P271, DOI 10.1016/j.semradonc.2025.02.011
   Anshasi H, 2025, COMPLEMENT THER MED, V92, DOI 10.1016/j.ctim.2025.103197
   Barati S, 2025, J PHOTOCH PHOTOBIO B, V264, DOI 10.1016/j.jphotobiol.2025.113115
   Bissonnette C MK, 2020, J Mich Dent Assoc
   [陈卫宏 Chen Weihong], 2022, [上海交通大学学报. 医学版, Journal of Shanghai Jiaotong University .Medical Science], V42, P635
   Chen YB, 2019, Journal of Traditional Chinese Medicine
   Courtois E, 2021, BMC ORAL HEALTH, V21, DOI 10.1186/s12903-021-01574-4
   de Sales PVA, 2025, ACTA CIR BRAS, V40, DOI 10.1590/acb403125
   Duan YT, 2025, BMJ EVID-BASED MED, DOI 10.1136/bmjebm-2024-113497
   Elad S, 2022, CA-CANCER J CLIN, V72, P57, DOI 10.3322/caac.21704
   Elsaadany B, 2024, BMC ORAL HEALTH, V24, DOI 10.1186/s12903-024-04379-3
   Garcia MK, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.16910
   Goel G, 2024, J CANCER RES THER, V20, P1564, DOI 10.4103/jcrt.jcrt_1200_23
   Higgins JT., 2019, J; Chandler, J; Cumpston, M; Li, T; Page, MJ; Welch, VA (2019) Cochrane Handbook for Systematic Reviews of Interventions, V2, DOI [10.1002/9781119536604, DOI 10.1002/9781119536604]
   Hu WJ., 2024, J Qiqihar Med Univ, V45, P1693
   Hu Y., 2024, Chinese Modern Doctor, V62, P82
   Hu ZX, 2013, Journal of Nursing Science
   Hua YC., 2022, Southeast National Defense Medical Journal, V24, P537
   Jiang S., 2020, General Medicine: Clinical and Education, V18, P31
   [蒋瑛 Jiang Ying], 2023, [军事医学, Military Medical Sciences], V47, P657
   Jicman Stan D, 2022, Medicina (Kaunas), V58
   Juan Z, 2025, INT J SURG, V111, P2018, DOI 10.1097/JS9.0000000000002147
   Kim SY, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/9874207
   Kuang HJ, 2025, J Integr Med
   Lai Q., 2021, Clinical observation on the therapeutic effect of fire needle in chemotherapy-induced oral mucositis in breast cancer
   Li KX, 2017, ORAL ONCOL, V72, P32, DOI 10.1016/j.oraloncology.2017.06.026
   Li QW, 2020, CHIN MED-UK, V15, DOI 10.1186/s13020-020-00333-x
   Li X, 2023, Zhejiang Journal of Traumatic Surgery, V28
   Li YX, 2024, FRONT CELL INFECT MI, V14, DOI 10.3389/fcimb.2024.1477143
   Li YJ, 2024, STRAHLENTHER ONKOL, V200, P895, DOI 10.1007/s00066-024-02255-1
   [梁妍景 Liang Yanjing], 2023, [上海交通大学学报. 医学版, Journal of Shanghai Jiaotong University .Medical Science], V43, P208
   Liu DD., 2024, Journal of Qiannan Medical University for Nationalities, V37, P265
   LOCKHART PB, 1981, J DERMATOL SURG ONC, V7, P1019, DOI 10.1111/j.1524-4725.1981.tb00208.x
   Michel-Cherqui M, 2024, SUPPORT CARE CANCER, V32, DOI 10.1007/s00520-024-08768-w
   Münstedt K, 2019, COMPLEMENT THER CLIN, V34, P145, DOI 10.1016/j.ctcp.2018.11.016
   Nicolatou-Galitis O, 2021, SUPPORT CARE CANCER, V29, P5701, DOI 10.1007/s00520-021-06048-5
   Niruthisard S, 2024, PAIN REP, V9, DOI 10.1097/PR9.0000000000001188
   Nurhidayah I, 2024, BMC COMPLEMENT MED, V24, DOI 10.1186/s12906-024-04710-z
   Oh JE, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.813748
   Parra-Rojas S, 2025, BIOMEDICINES, V13, DOI 10.3390/biomedicines13020268
   Pereira-Riveros T, 2025, DENT J-BASEL, V13, DOI 10.3390/dj13060254
   Qi J., 2018, J Liaoning Univ Tradit Chin Med, V20, P216
   Shen BY, 2013, Chinese Journal of Traditional Chinese Medicine, V31
   Sun Y., 2019, World Latest Medicine Information Abstracts, V19, P1
   Villa A, 2021, SUPPORT CARE CANCER, V29, P6061, DOI 10.1007/s00520-021-06177-x
   Wang M, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1147718
   Wang ZH, 2025, NEUROSCIENCE, V573, P300, DOI 10.1016/j.neuroscience.2025.03.053
   Wu YQ, 2025, CANCER TREAT REV, V133, DOI 10.1016/j.ctrv.2025.102883
   Xia J, 2025, INT J ORAL SCI, V17, DOI 10.1038/s41368-025-00382-8
   Xie QH., 2024, Clinical Rational Drug Use, V17, P135
   Yang SK, 2015, Journal of Integrated Traditional and Western Medicine Research, V7
   Yoshida K, 2024, SUPPORT CARE CANCER, V32, DOI 10.1007/s00520-024-08836-1
   Yu YM., 2014, J Navy Med Univ, V117-118, P121
   Zhang ZX, 2025, BMC COMPLEMENT MED, V25, DOI 10.1186/s12906-025-04930-x
NR 55
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD SEP 23
PY 2025
VL 33
IS 10
AR 873
DI 10.1007/s00520-025-09931-7
PG 14
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 7SE6S
UT WOS:001578400700002
PM 40987848
DA 2026-01-16
ER

PT J
AU Xing, RY
   Yang, Y
   Zhang, M
   Wang, HY
   Tan, MY
   Gao, C
   Yang, C
   Zhai, MY
   Xie, YH
AF Xing, Ruyi
   Yang, Yang
   Zhang, Min
   Wang, Hanyu
   Tan, Mengyuan
   Gao, Chen
   Yang, Chao
   Zhai, Mingyu
   Xie, Yanhu
TI Effect of Transcutaneous Electrical Acupoint Stimulation Combined with
   Transversus Abdominis Plane Block on Postoperative Recovery in Elderly
   Patients Undergoing Laparoscopic Gastric Cancer Surgery: A Randomized
   Controlled Trial
SO PAIN AND THERAPY
LA English
DT Article
DE Transcutaneous electrical acupoint stimulation; Laparoscopic surgery;
   Postoperative pain; Transversus abdominis plane block; Recovery
ID MEASURING QUALITY; DOUBLE-BLIND; ACUPUNCTURE; RESPONSES; MORPHINE;
   SCORE; PAIN
AB Introduction This study assessed the influence of transcutaneous electrical acupoint stimulation (TEAS) combined with transversus abdominis plane block (TAPB) on the recovery of elderly patients undergoing laparoscopic gastric cancer surgery. Methods Ninety patients (age >= 60 years) undergoing laparoscopic gastric cancer surgery were randomly divided into general anesthesia group (group G), TAPB group (group NG), and TEAS combined with TAPB group (group NTG). Patients in the NTG group received TEAS at PC6, LI4, and ST36 acupoints and TAPB. Patients in the NG group received TAPB. The quality of recovery (QoR) was assessed using the QoR-15 questionnaire. The percentages of T lymphocyte subsets were determined. Consumption of anesthetics, extubation time, visual analog scale (VAS) scores, time of first postoperative ambulation and flatus, and postoperative adverse events were also recorded. Results QoR-15 scores on postoperative day (POD) 3 and POD 7 were higher in the NTG group than in the G and NG groups (P < 0.05). On POD 1 and POD 3, the percentages of CD3(+) and CD4(+) T cells and the CD4(+)/CD8(+) ratio were higher and the percentage of CD8(+) T cells was lower in the NTG group than in the G and NG groups (P < 0.05). Remifentanil consumption, and the incidence of postoperative nausea and vomiting (PONV) were lower and extubation time and time of first postoperative flatus were shorter in the NTG group than in the G and NG groups (P < 0.05). Compared with the G group, the VAS scores on POD 1 were lower in the NG group and those on POD 2 were lower in the NTG group (P < 0.05). Conclusion The combination of TEAS and TAPB ameliorated postoperative pain, improved immune and gastrointestinal function, reduced the incidence of PONV, and effectively promoted postoperative recovery in elderly patients undergoing laparoscopic gastric cancer surgery.
C1 [Xing, Ruyi; Yang, Yang; Zhang, Min; Wang, Hanyu; Tan, Mengyuan; Gao, Chen; Yang, Chao; Zhai, Mingyu; Xie, Yanhu] Univ Sci & Technol China, Div Life Sci & Med, USTC, Affiliated Hosp 1,Dept Anaesthesiol, Hefei 230001, Anhui, Peoples R China.
C3 Chinese Academy of Sciences; University of Science & Technology of
   China, CAS
RP Zhai, MY; Xie, YH (corresponding author), Univ Sci & Technol China, Div Life Sci & Med, USTC, Affiliated Hosp 1,Dept Anaesthesiol, Hefei 230001, Anhui, Peoples R China.
EM zmynj1@126.com; xyh200701@sina.cn
CR Benyamin R, 2008, PAIN PHYSICIAN, V11, pS105
   Cabioglu MT, 2008, AM J CHINESE MED, V36, P25, DOI 10.1142/S0192415X08005552
   Carr DB, 1999, LANCET, V353, P2051, DOI 10.1016/S0140-6736(99)03313-9
   Chazapis M, 2016, BRIT J ANAESTH, V116, P241, DOI 10.1093/bja/aev413
   Chen JB, 2020, INT J SURG, V73, P57, DOI 10.1016/j.ijsu.2019.10.036
   Chen JH, 2020, THORAC CANCER, V11, P928, DOI 10.1111/1759-7714.13343
   Chen YQ, 2016, J CLIN ANESTH, V32, P255, DOI 10.1016/j.jclinane.2016.03.019
   Chi YL, 2019, AM J CHINESE MED, V47, P1445, DOI 10.1142/S0192415X19500745
   Francis NK, 2015, COLORECTAL DIS, V17, pO148, DOI 10.1111/codi.13002
   Frey UH, 2009, BRIT J ANAESTH, V102, P620, DOI 10.1093/bja/aep014
   Ghai B, 2022, J ANAESTH CLIN PHARM, V38, P3, DOI 10.4103/joacp.JOACP_362_19
   Hamid HKS, 2021, LANGENBECK ARCH SURG, V406, P273, DOI 10.1007/s00423-020-01995-9
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   HAN JS, 1991, PAIN, V47, P295, DOI 10.1016/0304-3959(91)90218-M
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   Houghtling RA, 2000, ANN NY ACAD SCI, V917, P771
   Hu SX, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105219
   Jarrar A, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2018-025818
   Kleif J, 2018, BRIT J ANAESTH, V120, P28, DOI 10.1016/j.bja.2017.11.013
   Lai Min, 2008, Zhen Ci Yan Jiu, V33, P245
   Lee A, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003281.pub4
   Li H, 2015, WORLD J GASTROENTERO, V21, P8304, DOI 10.3748/wjg.v21.i27.8304
   Lv Y, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000010969
   Meng D, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/9922879
   Myles PS, 2018, BRIT J ANAESTH, V120, P705, DOI 10.1016/j.bja.2017.12.037
   Myles PS, 2016, ANESTHESIOLOGY, V125, P39, DOI 10.1097/ALN.0000000000001158
   Nieboer TE, 2009, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD003677.pub4, 10.1002/14651858.CD003677.pub5]
   Qu Li Zhe, 2020, Zhen Ci Yan Jiu, V45, P136, DOI 10.13702/j.1000-0607.1904016
   Sacerdote P, 2000, ANESTH ANALG, V90, P1411, DOI 10.1097/00000539-200006000-00028
   Song BJ, 2020, NAT SCI SLEEP, V12, P809, DOI 10.2147/NSS.S270739
   Stark PA, 2013, ANESTHESIOLOGY, V118, P1332, DOI 10.1097/ALN.0b013e318289b84b
   Tan SJ, 2016, INT J SURG, V33, P124, DOI 10.1016/j.ijsu.2016.07.077
   Tian CT, 2015, CHINESE MED J-PEKING, V128, P105, DOI 10.4103/0366-6999.147828
   Tran D, 2019, ANESTHESIOLOGY, V131, P1166, DOI 10.1097/ALN.0000000000002842
   Tu Q, 2018, TECHNOL CANCER RES T, V17, DOI 10.1177/1533033818806477
   Wang H, 2014, BRIT J ANAESTH, V112, P1075, DOI 10.1093/bja/aeu001
   Wu HX, 2016, EXP THER MED, V11, P495, DOI 10.3892/etm.2015.2913
   Yu XD, 2020, TRIALS, V21, DOI 10.1186/s13063-019-3892-4
   Zhang W, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/5650413
   Zhao Y, 2021, BMC ANESTHESIOL, V21, DOI 10.1186/s12871-021-01317-6
   Zhou X, 2021, CANCER MANAG RES, V13, P1449, DOI 10.2147/CMAR.S292325
NR 41
TC 21
Z9 26
U1 3
U2 20
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2193-8237
EI 2193-651X
J9 PAIN THER
JI PAIN THER.
PD DEC
PY 2022
VL 11
IS 4
BP 1327
EP 1339
DI 10.1007/s40122-022-00429-2
EA SEP 2022
PG 13
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5X6DI
UT WOS:000853452700001
PM 36098938
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Semeniuk, G
   Bahadini, B
   Ahn, E
   Zain, J
   Cheng, J
   Govindarajan, A
   Rose, J
   Lee, RT
AF Semeniuk, George
   Bahadini, Bahareh
   Ahn, Eugene
   Zain, Jasmine
   Cheng, Jessica
   Govindarajan, Ameish
   Rose, Judy
   Lee, Richard T.
TI Integrative Oncology and the Clinical Care Network: Challenges and
   Opportunities
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE integrative oncology; clinical care network; implementation
ID QUALITY-OF-LIFE; BREAST-CANCER PATIENTS; STRESS REDUCTION; MASSAGE
   THERAPY; ALTERNATIVE MEDICINE; PALLIATIVE CARE; ACUPUNCTURE; SURVIVORS;
   PAIN; HEALTH
AB Integrative oncology is a new and growing field of cancer care. Integrative oncology is a patient-centered, evidence-based field of comprehensive cancer care that utilizes integrative therapies such as mind-body practices, acupuncture, massage, music therapy, nutrition, and exercise in collaboration with conventional cancer treatments. Patient interest and utilization has been growing over the past two decades. Clinical research has shown the benefits of these approaches to improving symptom management and quality of life, and is now being incorporated into national guidelines from the National Comprehensive Cancer Network (NCCN) and American Society for Clinical Oncology (ASCO). The availability of these services at cancer centers is growing, although the structure and implementation of integrative oncology remains highly variable. This article discusses the benefits of integrative oncology and provides an overview of the current state of integrative oncology programs nationwide. Current challenges and opportunities for cancer centers to provide integrative services is reviewed in the areas of programmatic structure, clinical service, education, and research.
C1 [Semeniuk, George; Bahadini, Bahareh; Ahn, Eugene; Zain, Jasmine; Cheng, Jessica; Govindarajan, Ameish; Rose, Judy; Lee, Richard T.] City Hope Comprehens Canc Ctr, Duarte, CA 91010 USA.
   [Ahn, Eugene] City Hope Chicago, Zion, IL 60099 USA.
C3 City of Hope
RP Lee, RT (corresponding author), City Hope Comprehens Canc Ctr, Duarte, CA 91010 USA.
EM gsemeniuk@coh.org; bbahadini@coh.org; eugene.ahn@ctca-hope.com;
   jazain@coh.org; jescheng@coh.org; agovindarajan@coh.org; jrose@coh.org;
   richlee@coh.org
RI ; Cheng, Jessica/KGK-3608-2024
OI zain, jasmine/0000-0003-4308-629X; Zain, Jihad/0009-0009-0753-1019;
   Govindarajan, Ameish/0000-0002-8113-8524; Cheng,
   Jessica/0000-0003-1497-9398
CR [Adler N.E. Institute of Medicine (IOM) Institute of Medicine (IOM)], 2008, Cancer care for the whole patient: Meeting psychosocial health needs, DOI DOI 10.17226/11993
   Andersen BL, 2008, CANCER-AM CANCER SOC, V113, P3450, DOI 10.1002/cncr.23969
   [Anonymous], 2021, Meditation: In Depth
   Antoni MH, 2006, NAT REV CANCER, V6, P240, DOI 10.1038/nrc1820
   Barnes Patricia M, 2004, Adv Data, P1
   Bower JE, 2015, CANCER-AM CANCER SOC, V121, P1231, DOI 10.1002/cncr.29194
   Brauer JA, 2010, J ALTERN COMPLEM MED, V16, P183, DOI 10.1089/acm.2009.0354
   Campbell KL, 2019, MED SCI SPORT EXER, V51, P2375, DOI 10.1249/MSS.0000000000002116
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Chlebowski RT, 2020, J CLIN ONCOL, V38, P1419, DOI 10.1200/JCO.19.00435
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Clarke Tainya C, 2018, NCHS Data Brief, P1
   Cramer H, 2012, CURR ONCOL, V19, pE343, DOI 10.3747/co.19.1016
   Cramer H, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010802.pub2
   Danhauer SC, 2017, SUPPORT CARE CANCER, V25, P1357, DOI 10.1007/s00520-016-3556-9
   Dans M, 2021, J NATL COMPR CANC NE, V19, P780, DOI 10.6004/jnccn.2021.0033
   Dong B, 2021, BMC COMPLEMENT MED, V21, DOI 10.1186/s12906-020-03193-y
   Dusek JA, 2018, J ALTERN COMPLEM MED, V24, P557, DOI 10.1089/acm.2017.0203
   Finley DJ, 2021, SURG ONCOL, V37, DOI 10.1016/j.suronc.2021.101525
   Fu WW, 2016, ANN PALLIAT MED, V5, P93, DOI 10.21037/apm.2016.03.06
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Gu J, 2015, CLIN PSYCHOL REV, V37, P1, DOI 10.1016/j.cpr.2015.01.006
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hoffman CJ, 2012, J CLIN ONCOL, V30, P1335, DOI 10.1200/JCO.2010.34.0331
   International Agency for Research on Cancer Latest, 2020, GLOB CANC DAT CANC B
   Jiang C, 2021, SUPPORT CARE CANCER, V29, P5777, DOI 10.1007/s00520-021-06081-4
   Kinkead B, 2018, CANCER-AM CANCER SOC, V124, P546, DOI 10.1002/cncr.31064
   Kutner JS, 2008, ANN INTERN MED, V149, P369, DOI 10.7326/0003-4819-149-6-200809160-00003
   Larbi OM, 2021, JCO ONCOL PRACT, V17, P672, DOI 10.1200/OP.20.00471
   Latte-Naor S, 2019, J ONCOL PRACT, V15, P7, DOI 10.1200/JOP.18.00554
   Lee K, 2023, BMC CANCER, V23, DOI 10.1186/s12885-023-10884-5
   Lee RT, 2021, CANCER-AM CANCER SOC, V127, P1827, DOI 10.1002/cncr.33324
   Lee RT, 2014, J CLIN ONCOL, V32, P4095, DOI 10.1200/JCO.2014.55.8676
   Lee SH, 2015, INTEGR CANCER THER, V14, P297, DOI 10.1177/1534735415572885
   Lengacher CA, 2009, PSYCHO-ONCOLOGY, V18, P1261, DOI 10.1002/pon.1529
   Ligibel JA, 2022, J CLIN ONCOL, V40, P2491, DOI 10.1200/JCO.22.00687
   Lin KY, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1155/2011/659876
   Lyman GH, 2018, J ONCOL PRACT, V14, P495, DOI 10.1200/JOP.18.00283
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   Metin ZG, 2019, EUR J ONCOL NURS, V42, P116, DOI 10.1016/j.ejon.2019.09.003
   Mishra Suruchi, 2021, NCHS Data Brief, P1
   Musial F, 2011, FORSCH KOMPLEMENTMED, V18, P192, DOI 10.1159/000330714
   Nahin Richard L, 2016, Natl Health Stat Report, P1
   Narayanan S, 2021, INTEGR CANCER THER, V20, DOI 10.1177/1534735421999101
   Newmaster SG, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-222
   Niazi AK, 2011, N AM J MED SCI, V3, P20, DOI 10.4297/najms.2011.320
   Paley CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub3
   Pan YQ, 2014, INT J CLIN ONCOL, V19, P829, DOI 10.1007/s10147-013-0635-5
   Pierce JP, 2007, JAMA-J AM MED ASSOC, V298, P289, DOI 10.1001/jama.298.3.289
   Piet J, 2012, J CONSULT CLIN PSYCH, V80, P1007, DOI 10.1037/a0028329
   Reeves MM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13114091
   Rock CL, 2022, CA-CANCER J CLIN, V72, P230, DOI 10.3322/caac.21719
   Sanford NN, 2019, JAMA ONCOL, V5, P735, DOI 10.1001/jamaoncol.2019.0349
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Tao WW, 2016, J PAIN SYMPTOM MANAG, V51, P728, DOI 10.1016/j.jpainsymman.2015.11.027
   Thompson-Lastad A, 2019, J ALTERN COMPLEM MED, V25, P733, DOI 10.1089/acm.2019.0073
   Valle CG, 2023, CANCER-AM CANCER SOC, V129, P461, DOI 10.1002/cncr.34556
   Van Blarigan EL, 2018, JAMA ONCOL, V4, P783, DOI 10.1001/jamaoncol.2018.0126
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
   Wu XY, 2015, SCI REP-UK, V5, DOI 10.1038/srep16776
   Yeung KS, 2018, ONCOLOGY-NY, V32, P516
   Yun Hyeongjun, 2017, Journal of the National Cancer Institute Monographs, P29, DOI [10.1093/jncimonographs/lgx004, 10.1093/jncimonographs/lgx004]
   Zainal NZ, 2013, PSYCHO-ONCOLOGY, V22, P1457, DOI 10.1002/pon.3171
NR 68
TC 12
Z9 13
U1 1
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN
PY 2023
VL 12
IS 12
AR 3946
DI 10.3390/jcm12123946
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA K3GO4
UT WOS:001015357600001
PM 37373639
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Garcia, MK
   McQuade, J
   Lee, R
   Haddad, R
   Spano, M
   Cohen, L
AF Garcia, M. Kay
   McQuade, Jennifer
   Lee, Richard
   Haddad, Robin
   Spano, Michael
   Cohen, Lorenzo
TI Acupuncture for Symptom Management in Cancer Care: an Update
SO CURRENT ONCOLOGY REPORTS
LA English
DT Article
DE Acupuncture; Cancer; Integrative medicine; Complementary medicine;
   Symptom management; Pain; Fatigue; Peripheral neuropathy; Lymphedema;
   Hot flashes
ID RANDOMIZED CONTROLLED-TRIAL; INDUCED PERIPHERAL NEUROPATHY;
   RADIATION-INDUCED XEROSTOMIA; BREAST-CANCER; MUSCULOSKELETAL SYMPTOMS;
   VASOMOTOR SYMPTOMS; FEASIBILITY TRIAL; DOUBLE-BLIND; HOT FLASHES;
   DUAL-CENTER
AB In a previous systematic review of the worldwide literature of randomized controlled trials (RCTs) involving needle insertion into acupuncture points for symptom management in cancer patients, we identified only one high-quality RCT that was deemed to have a low risk of bias. Medline, Embase, CINAHL, Cochrane (all databases), Scopus, and PubMed were searched from inception through December 2011 with no language limits applied. A total of 41 RCTs met all inclusion criteria and were rated. In the current review, we examined 18 trials published since our last report. The purpose of this update was to emphasize important recent findings and discuss how concerns such as blinding, separating non-specific placebo effects from specific needling effects, determining biologic mechanisms and dosing parameters, evaluating determinants of response such as expectation, controlling for sources of bias, and the lack of standardization in treatment and study methods may affect the interpretation of study results.
C1 [Garcia, M. Kay; McQuade, Jennifer; Lee, Richard; Haddad, Robin; Spano, Michael; Cohen, Lorenzo] Univ Texas MD Anderson Canc Ctr, Integrat Med Program, Dept Gen Oncol, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center
RP Garcia, MK (corresponding author), Univ Texas MD Anderson Canc Ctr, Integrat Med Program, Dept Gen Oncol, 1515 Holcombe Blvd,Unit 0462, Houston, TX 77030 USA.
EM kaygarcia@mdanderson.org; jmcquade@mdanderson.org; rtlee@mdanderson.org;
   rhaddad@mdanderson.org; mrspano@mdanderson.org; lcohen@mdanderson.org
RI Lee, Richard/AAS-1416-2021
OI Lee, Richard/0000-0001-9916-6155
CR [Anonymous], COCHRANE HDB SYSTEMA
   [Anonymous], EVID BASED COMPLEMEN
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Bao T, 2014, CANCER-AM CANCER SOC, V120, P381, DOI 10.1002/cncr.28352
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Bokmand S, 2013, BREAST, V22, P320, DOI 10.1016/j.breast.2012.07.015
   Cassileth BR, 2013, CANCER-AM CANCER SOC, V119, P2455, DOI 10.1002/cncr.28093
   Crew Katherine D, 2007, J Cancer Surviv, V1, P283, DOI 10.1007/s11764-007-0034-x
   Deng G, 2007, J CLIN ONCOL, V25, P5584, DOI 10.1200/JCO.2007.12.0774
   Deng G, 2013, SUPPORT CARE CANCER, V21, P1735, DOI 10.1007/s00520-013-1720-z
   Ezzo JM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002285.pub2
   Braga FDF, 2011, BRAZ ORAL RES, V25, P180
   Frisk J, 2008, CLIMACTERIC, V11, P166, DOI 10.1080/13697130801958709
   Frisk J, 2009, EUR UROL, V55, P156, DOI 10.1016/j.eururo.2008.02.002
   Frisk JW, 2014, SUPPORT CARE CANCER, V22, P1409, DOI 10.1007/s00520-014-2126-2
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Guo J, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/163850
   Henry NL, 2010, CANCER-AM CANCER SOC, V116, P4360, DOI 10.1002/cncr.25385
   Hervik J, 2009, BREAST CANCER RES TR, V116, P311, DOI 10.1007/s10549-008-0210-3
   Huo ZJ, 2013, CHIN J INTEGR MED, V19, P187, DOI 10.1007/s11655-012-1240-6
   Kaptchuk TJ, 2008, BMJ-BRIT MED J, V336, P999, DOI 10.1136/bmj.39524.439618.25
   Liljegren A, 2012, BREAST CANCER RES TR, V135, P791, DOI 10.1007/s10549-010-1283-3
   Lu LM, 2013, EXPERT REV ANTICANC, V13, P489, DOI [10.1586/era.13.27, 10.1586/ERA.13.27]
   Mao JJ, 2009, INTEGR CANCER THER, V8, P123, DOI 10.1177/1534735409332903
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Meng ZQ, 2012, EUR J CANCER, V48, P1692, DOI 10.1016/j.ejca.2011.12.030
   Meng ZQ, 2012, CANCER-AM CANCER SOC, V118, P3337, DOI 10.1002/cncr.26550
   Molassiotis A, 2013, ANN ONCOL, V24, P1645, DOI 10.1093/annonc/mdt034
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Nedstrand E, 2005, CLIMACTERIC, V8, P243, DOI 10.1080/13697130500118050
   Ng SSM, 2013, GASTROENTEROLOGY, V144, P307, DOI 10.1053/j.gastro.2012.10.050
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Posadzki P, 2013, SUPPORT CARE CANCER, V21, P2067, DOI 10.1007/s00520-013-1765-z
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   Simcock R, 2013, ANN ONCOL, V24, P776, DOI 10.1093/annonc/mds515
   Smith C, 2013, ACUPUNCT MED, V31, P9, DOI 10.1136/acupmed-2012-010228
   Towler P, 2013, SUPPORT CARE CANCER, V21, P2913, DOI 10.1007/s00520-013-1882-8
   Vickers AJ., 2012, Arch. Intern. Med
   Zeng YC, 2014, INTEGR CANCER THER, V13, P193, DOI 10.1177/1534735413510024
NR 41
TC 26
Z9 28
U1 1
U2 45
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3790
EI 1534-6269
J9 CURR ONCOL REP
JI Curr. Oncol. Rep.
PD DEC
PY 2014
VL 16
IS 12
AR 418
DI 10.1007/s11912-014-0418-9
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AU0RX
UT WOS:000345332900006
PM 25325937
DA 2026-01-16
ER

PT J
AU Han, Q
   Yang, L
   Huang, SY
   Yeung, JWF
   Chen, XH
   Xue, H
   Xu, LP
   Suen, LKP
AF Han, Qiong
   Yang, Liu
   Huang, Shuang-Yan
   Yeung, Jerry W. F.
   Chen, Xiao-Huan
   Xue, Hui
   Xu, Li-Ping
   Suen, Lorna K. P.
TI Effectiveness of auricular point therapy for cancer-related fatigue: A
   systematic review and meta-analysis
SO JOURNAL OF ADVANCED NURSING
LA English
DT Review
DE auricular point therapy; cancer-related fatigue; fatigue; meta-analysis;
   nursing; systematic review
ID RANDOMIZED CONTROLLED-TRIAL; ALTERNATIVE MEDICINE; RISK-FACTORS;
   ACUPRESSURE; SURVIVORS; PAIN; COMPLEMENTARY; CHEMOTHERAPY; ACUPUNCTURE;
   DISABILITY
AB Aims To systemically review the efficacy and safety of auricular point therapy in patients with cancer-related fatigue.
   Design A systematic review and meta-analysis of randomized controlled trials.
   Data sources Eight electronic databases (PubMed, CENTRAL, Embase, CINAHL, Web of Science, China Biology Medicine, China National Knowledge Infrastructure and WanFang Data Knowledge Service Platform) were explored for randomized controlled trials from their inception to 1 December 2018.
   Review methods The risk of bias assessment tool was adopted in accordance with Cochrane Handbook 5.3.0. All included studies reported the effects on cancer-related fatigue as the primary outcome. Effect size was estimated using relative risk, standardized mean difference or mean difference with a corresponding 95% confidence interval. Review Manager 5.3 was used for meta-analysis.
   Results Six studies comprising 394 patients were included. The results of meta-analysis showed that auricular point therapy plus standard care produced more positive effects on cancer-related fatigue and quality of life than standard care alone. It could significantly improve the role, emotional, cognitive, and social functions of patients with cancer-related fatigue.
   Conclusions Auricular point therapy may be a safe therapy to relieve cancer-related fatigue and enhance the quality of life of patients with cancer. However, the evidence was inconclusive due to limitations on the quantity and quality of included studies. Rigorously designed randomized controlled trials should be conducted to verify the results.
   Impact Auricular point therapy is a simple and safe therapeutic approach that may alleviate cancer-related fatigue of common complications in patients with cancer and it is worth promoting in the community, family, and hospital. Moreover, the research findings can provide suggestions and inspiration for nurses and researchers to implement the proposal, which is conducive to design more rigorous and high-quality randomized controlled trials.
C1 [Han, Qiong; Yang, Liu; Huang, Shuang-Yan; Xue, Hui] Fujian Univ Tradit Chinese Med, Sch Nursing, 1 Qiu Yang Rd, Fuzhou, Fujian, Peoples R China.
   [Yeung, Jerry W. F.; Suen, Lorna K. P.] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
   [Chen, Xiao-Huan] Fujian Prov Hosp, Fuzhou, Peoples R China.
   [Xu, Li-Ping] Fujian Univ Tradit Chinese Med, Affiliated Peoples Hosp 3, Fuzhou, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Hong Kong Polytechnic
   University; Fujian Provincial Hospital; Fujian University of Traditional
   Chinese Medicine
RP Yang, L (corresponding author), Fujian Univ Tradit Chinese Med, Sch Nursing, 1 Qiu Yang Rd, Fuzhou, Fujian, Peoples R China.
EM yangliu@fjtcm.edu.cn
RI Yeung, Wing-Fai/E-7971-2013; Suen, Lorna/F-5077-2014
OI Yeung, Wing-Fai/0000-0002-7980-3126; Han, Qiong/0000-0002-5340-3845; 
CR Abrahams HJG, 2016, ANN ONCOL, V27, P965, DOI 10.1093/annonc/mdw099
   [Anonymous], NCCN GUID VERS 2 201
   [Anonymous], 1990, Report of the Working Group on Auricular Acupuncture Nomenclature
   Atkinson TM, 2017, JAMA ONCOL, V3, P738, DOI 10.1001/jamaoncol.2016.3328
   Behringer K, 2016, J CLIN ONCOL, V34, P4329, DOI 10.1200/JCO.2016.67.7450
   Bohlius J, 2014, BRIT J CANCER, V111, P33, DOI 10.1038/bjc.2014.171
   Bower JE, 2014, NAT REV CLIN ONCOL, V11, P597, DOI 10.1038/nrclinonc.2014.127
   Bower JE, 2014, J CLIN ONCOL, V32, P1840, DOI 10.1200/JCO.2013.53.4495
   Bower JE, 2011, J CLIN ONCOL, V29, P3517, DOI 10.1200/JCO.2011.36.1154
   DING JX, 2017, TODAY NURSE, V7, P98
   DRAGER DL, 2015, COCHRANE DB SYST REV, V5, pR500
   Eghbali M, 2016, COMPLEMENT THER CLIN, V24, P189, DOI 10.1016/j.ctcp.2016.06.006
   Escalante CP, 2014, CANCER J, V20, P8, DOI 10.1097/PPO.0000000000000018
   Feng C.X., 1994, Chinese Auricular Therapy
   Garner BK, 2018, MED ACUPUNCT, V30, P262, DOI 10.1089/acu.2018.1294
   Guan Z.X., 2002, Auricular Therapy
   Higgins J., 2011, COCHRANE COLLABORATI
   Hoffmann TC, 2014, BMJ-BRIT MED J, V348, DOI [10.1136/bmj.g1687, 10.1055/s-0041-111066]
   Huang DY, 2014, COMPUT SPEECH LANG, V28, P392, DOI 10.1016/j.csl.2013.06.002
   Janelsins MC, 2011, CLIN BREAST CANCER, V11, P161, DOI 10.1016/j.clbc.2011.03.013
   Jones JM, 2016, J CANCER SURVIV, V10, P51, DOI 10.1007/s11764-015-0450-2
   Kapoor A, 2015, SOUTH ASIAN J CANCER, V4, P21, DOI 10.4103/2278-330X.149942
   Kreissl S, 2016, LANCET ONCOL, V17, P1453, DOI 10.1016/S1470-2045(16)30093-6
   Kua KP, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172289
   Larkey LK, 2015, ANN BEHAV MED, V49, P165, DOI 10.1007/s12160-014-9645-4
   Lee S, 2019, APPL NURS RES, V45, P12, DOI 10.1016/j.apnr.2018.11.005
   LI WY, 2004, CHINESE ACUPUNCTURE, V9, P28
   LIN YZ, 2014, ZHEJIANG PREVENTIVE, V26, P796
   Linde K, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-75
   Marom T, 2016, MEDICINE, V95, P1, DOI 10.1097/MD.0000000000002695
   *NAT STAND INF SHA, 2008, GBT137342008 NAT STA
   Ni XS, 2019, SUPPORT CARE CANCER, V27, P3701, DOI 10.1007/s00520-019-04911-0
   Nilsson I, 2015, J NEUROSURG ANESTH, V27, P42, DOI 10.1097/ANA.0000000000000089
   Oleson T., 2014, Auriculotherapy Manual: Chinese and Western Systems of Ear Acupuncture
   Parkin DM, 2005, CA-CANCER J CLIN, V55, P74, DOI 10.3322/canjclin.55.2.74
   Ruela LD, 2018, REV ESC ENFERM USP, V52, DOI [10.1590/S1980-220X2017040503402, 10.1590/s1980-220x2017040503402]
   Shan Q.H., 1996, Auricular-point-pressing Therapy
   SHEN QP, 2009, CLIN OBSERVATION MEC, P38
   Shin J, 2018, WESTERN J NURS RES, V40, P67, DOI 10.1177/0193945916680362
   Stein DJ, 2017, GASTROENTEROL CLIN N, V46, P875, DOI 10.1016/j.gtc.2017.08.015
   Tan J., 2014, EVID-BASED COMPL ALT, DOI [DOI 10.1155/2014/506758, 10.1155/2014/506758.]
   Tan JY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132989
   TAN JY, 2014, EVID-BASED COMPL ALT, V2014
   TIAN XX, 2018, CHINESE J PHYS, V20, P1108
   Vadiraja HS, 2017, INDIAN J PALLIAT CAR, V23, P247, DOI 10.4103/IJPC.IJPC_95_17
   WANG JZ, 2013, ZHEJIANG J TRADITION, V8, P618
   WANG XQ, 2016, J NURS MANAGE, V16, P562
   YANG JL, 2016, W TRADITIONAL CHINES, V29, P108
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   YENNU S, 2016, J CLIN ONCOL, V34
   YU LF, 2012, GEN NURSING, V10, P2689
   Zhang QT, 2018, COMMUN BIOL, V1, DOI 10.1038/s42003-018-0154-z
   ZHAO JJ, 2016, J LIAONING U TRADITI, V18, P82
   Zick SM, 2016, JAMA ONCOL, V2, P1470, DOI 10.1001/jamaoncol.2016.1867
   Zou C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122724
NR 55
TC 26
Z9 28
U1 1
U2 38
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0309-2402
EI 1365-2648
J9 J ADV NURS
JI J. Adv. Nurs.
PD AUG
PY 2020
VL 76
IS 8
BP 1924
EP 1935
DI 10.1111/jan.14375
EA MAY 2020
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA QI1VW
UT WOS:000534285900001
PM 32428970
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Sawada, NO
   Zago, MMF
   Galvao, CM
   Cardozo, FMC
   Zandonai, AP
   Okino, L
   Nicolussi, AC
AF Sawada, Namie Okino
   Fontao Zago, Marcia Maria
   Galvao, Cristina Maria
   Coelho Cardozo, Fernanda Mara
   Zandonai, Alexandra Paola
   Okino, Liyoko
   Nicolussi, Adriana Cristina
TI The Outcomes of Visualization and Acupuncture on the Quality of Life of
   Adult Cancer Patients Receiving Chemotherapy
SO CANCER NURSING
LA English
DT Article
DE Acupuncture; Cancer; Chemotherapy; Quality of life; Visualization
ID ALTERNATIVE MEDICINE; GUIDED IMAGERY; INDUCED NAUSEA; COMPLEMENTARY;
   RELAXATION; STIMULATION; PAIN
AB Background: The use of complementary and alternative medicine (CAM) to treat cancer patients has increased around the world, and its benefits have been described. These therapies represent an important theme in oncology and have been used in parallel with conventional therapies. Objective: This study aimed to assess the outcomes of using relaxation with visualization and acupuncture on the quality of life of cancer patients undergoing chemotherapy treatment and to compare these outcomes with patients who did not choose to receive the intervention. Methods: Participants chose to be in either the intervention group (IG) or control group (CG). They completed the Quality of Life Questionnaire-Core 30 at the start and end of chemotherapy. The IG was chosen by 38 patients with different types of cancer who completed weekly relaxation with visualization and acupuncture sessions, whereas the CG was composed of 37 patients who did not receive the intervention. Results: Statistically significant results evidenced an increase in global health and emotional and social functions and a decrease in fatigue and loss of appetite for the IG, and an increase in global health for the CG (P <= .05). A highly significant difference was found when comparing the post-chemotherapy scores of the Quality of Life Questionnaire-Core 30 in the global health domain between the CG and the IG (P <= .001), indicating positive outcomes of the CAM intervention. Conclusion: Adults with cancer are able to choose between involvement or not with this kind of CAM intervention. Global health could be improved by participating in this type of intervention. Implications for Practice: Choosing whether to be involved may be assisted by knowing the positive outcomes for some patients.
C1 [Sawada, Namie Okino] Univ Sao Paulo, Escola Enfermagem Ribeirao Preto, Coll Nursing Ribeirao Preto, BR-14040902 Sao Paulo, Brazil.
   [Okino, Liyoko] Ctr Univ Barao Maua, Brazilian Assoc Acupuncture, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Sawada, NO (corresponding author), Univ Sao Paulo, Escola Enfermagem Ribeirao Preto, Coll Nursing Ribeirao Preto, Av Bandeirantes 3900, BR-14040902 Sao Paulo, Brazil.
EM sawada@eerp.usp.br
RI Galvão, Cristina/L-9461-2015; Nicolussi, Aiana Cristina/M-1880-2015;
   Zago, Marcia/C-8205-2012; Sawada, Namie Okino/C-6112-2012
OI Galvão, Cristina/0000-0002-4141-7107; ZANDONAI, ALEXANA
   PAOLA/0000-0002-6424-8211; Nicolussi, Aiana
   Cristina/0000-0001-5600-7533; Sawada, Namie Okino/0000-0002-1874-3481
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Amorim MH, 1999, ENFERMAGEM PSICONEUR
   [Anonymous], J AM MED ASS
   Ballatori Enzo, 2003, Health Qual Life Outcomes, V1, P46, DOI 10.1186/1477-7525-1-46
   BONASSA EMA, 2000, ENFERMAGEM TERAPEUTI
   BRABO EP, 2006, THESIS UERJ RIO DE J
   Brasil Ministerio da Saude Secretaria de Atencao a Saude Basica. DdA, 2006, POL NAC PRAT INT COM
   BURISH TG, 1992, HEALTH PSYCHOL, V11, P17, DOI 10.1037/0278-6133.11.1.17
   BURISH TG, 1991, J CONSULT CLIN PSYCH, V59, P518, DOI 10.1037/0022-006X.59.4.518
   Chiappelli F, 2005, EVID-BASED COMPL ALT, V2, P453, DOI 10.1093/ecam/neh106
   Cohen M, 2007, RES SOCIAL WORK PRAC, V17, P313, DOI 10.1177/1049731506293741
   Collins Kimberly B, 2004, J Am Acad Nurse Pract, V16, P76
   ERNST E, 1995, BRIT J GEN PRACT, V45, P506
   Ezzo J, 2006, J ALTERN COMPLEM MED, V12, P489, DOI 10.1089/acm.2006.12.489
   Grant M., 1998, QUALITY LIFE NURSING, P3
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   HART J, 2006, ALTERN COMPLEMENT TH, V12, P208
   HECKER HU, 2007, PRATICA ACUPUNTURA
   HOFFMAN C, 2007, BREAST CANC RES S2, V9, P1
   HOU ZF, 1981, SCI SINICA, V24, P1166
   JIANG D, 1989, B HUNAN MED U, V14, P335
   KOLCABA K, 1992, ONCOL NURS FORUM, V26, P67
   León-Pizarro C, 2007, PSYCHO-ONCOLOGY, V16, P971, DOI 10.1002/pon.1171
   Lopes A, 2008, ONCOLOGIA GRADUACAO
   Lu Weidong, 2007, J Soc Integr Oncol, V5, P1, DOI 10.2310/7200.2006.035
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Luebbert K, 2001, PSYCHO-ONCOLOGY, V10, P490, DOI 10.1002/pon.537
   MA L, 2009, BAYLOR U MED CENT, V22, P138
   Mannix LK, 1999, HEADACHE, V39, P326, DOI 10.1046/j.1526-4610.1999.3905326.x
   Mehling WE, 2007, J PAIN SYMPTOM MANAG, V33, P258, DOI 10.1016/j.jpainsymman.2006.09.016
   Molassiotis A, 2005, ANN ONCOL, V16, P655, DOI 10.1093/annonc/mdi110
   *NAT CTR COMPL ALT, 2004, BKG, pD239
   Pan CX, 2000, J PAIN SYMPTOM MANAG, V20, P374, DOI 10.1016/S0885-3924(00)00190-1
   PARKMAN HP, 2003, TCM S, P83
   Pert C., 1997, MOL EMOTION
   Polit DF, 2004, FUNDAMENTOS PESQUISA, V5th
   Price S, 2006, INTEGR CANCER THER, V5, P308, DOI 10.1177/1534735406294899
   Roffe L, 2005, PSYCHO-ONCOLOGY, V14, P607, DOI 10.1002/pon.889
   Roscoe JA, 2000, J PAIN SYMPTOM MANAG, V20, P113, DOI 10.1016/S0885-3924(00)00159-7
   Roscoe JA, 2003, J PAIN SYMPTOM MANAG, V26, P731, DOI 10.1016/S0885-3924(03)00254-9
   Sawada NO, 2009, REV ESC ENFERM USP, V43, P581, DOI 10.1590/S0080-62342009000300012
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   Vickers AJ, 2004, J CLIN ONCOL, V22, P1731, DOI 10.1200/JCO.2004.04.102
   ZHAO X, 1999, ZHEN CI YAN JIU, P17
NR 44
TC 6
Z9 7
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD SEP-OCT
PY 2010
VL 33
IS 5
BP E21
EP E28
DI 10.1097/NCC.0b013e3181d86739
PG 8
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA 630YX
UT WOS:000280314000013
PM 20562622
DA 2026-01-16
ER

PT J
AU Li, XT
   Lampson, K
   Ahles, TA
   Root, JC
   Li, QS
   Li, YL
   Ahsan, A
   Mao, JJ
   Liou, KT
AF Li, Xiaotong
   Lampson, Kaitlin
   Ahles, Tim A.
   Root, James C.
   Li, Q. Susan
   Li, Yuelin
   Ahsan, Anam
   Mao, Jun J.
   Liou, Kevin T.
TI Feasibility and Preliminary Effects of Acupuncture for Cognitive
   Dysfunction in Diverse Cancer Survivors: A Pilot, Randomized,
   Placebo-Controlled Trial
SO CURRENT ONCOLOGY
LA English
DT Article
DE acupuncture; pilot study; cognitive dysfunction; cancer survivorship;
   feasibility
ID VERBAL-LEARNING TEST; FUNCTIONAL ASSESSMENT; IMPAIRMENT; MECHANISMS;
   MANAGEMENT; THERAPY; PREVALENCE; EFFICACY; QLQ-C30; MODEL
AB (1) Background: This pilot study evaluates the feasibility and preliminary effects of acupuncture for cancer-related cognitive dysfunction (CRCD) in cancer survivors. (2) Methods: A randomized trial comparing real acupuncture (RA) to sham acupuncture (SA) and waitlist control (WLC) among cancer survivors reporting cognitive difficulties. Interventions were delivered weekly over 10 weeks. Feasibility was evaluated by recruitment, treatment adherence, and assessment completion. Subjective CRCD was assessed by the Functional Assessment of Cancer Therapy-Cognitive Function-Perceived Cognitive Impairment subscale (FACT-Cog PCI) and objective CRCD was assessed by the Hopkins Verbal Learning Test-Revised (HVLT-R). (3) Results: 32 participants (57.1% of eligible patients) were enrolled. All participants in acupuncture groups completed >= 8 of 10 treatments. Assessment completion rate was 100% for all participants. From baseline to week 10, the RA group (n = 19) reported a clinically meaningful 17.3-point increase in FACT-Cog PCI (95% confidence interval [CI] 12.5 to 22.1), compared to 9.7 points (95% CI 2.8 to 16.7) in the SA group (n = 9), and 6.8 points (95% CI -3.7 to 17.2) in the WLC group (n = 4). In the subgroup analysis among patients with a below-average baseline HVLT-R (T-score < 50), the RA group (n = 8) increased FACT-Cog PCI scores by 20.4 (95% CI 13.6 to 27.3), compared to 11.1 points (95% CI 0.6 to 21.5) in the SA group (n = 5). The improvements from RA persisted through week 16 in both the total sample and the sub-group. Eleven mild adverse events were reported, with pain and bleeding at the needling sites being the most common. (4) Conclusions: The findings support the feasibility and safety of conducting a randomized, placebo-controlled trial to evaluate acupuncture for cognitive dysfunction in cancer survivors.
C1 [Li, Xiaotong; Lampson, Kaitlin; Li, Q. Susan; Mao, Jun J.; Liou, Kevin T.] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.
   [Ahles, Tim A.; Root, James C.; Li, Yuelin; Ahsan, Anam] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, New York, NY 10065 USA.
   [Li, Yuelin] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center
RP Liou, KT (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.
EM lix9@mskcc.org; lampsonk@mskcc.org; ahlest@mskcc.org; rootj@mskcc.org;
   liq2@mskcc.org; liy12@mskcc.org; anam.ahsann@gmail.com; maoj@mskcc.org;
   liouk@mskcc.org
RI Li, Xiaotong/HTN-2157-2023; Ahsan, Anam/AAX-9123-2020
OI Lampson, Kaitlin/0009-0003-5262-5707; Liou, Kevin/0000-0002-2438-9749
FU MSK's Integrative Medicine and Translational Research Fund and in part
   by an NIH/NCI Cancer Center Support Grant; MSK's Integrative Medicine
   and Translational Research Fund [P30 CA008748]; NIH/NCI Cancer Center
   Support Grant [K08CA266927]; National Cancer Institute's Mentored
   Clinical Scientist Research Career Development Award
FX This work was supported by MSK's Integrative Medicine and Translational
   Research Fund and in part by an NIH/NCI Cancer Center Support Grant (P30
   CA008748) and the National Cancer Institute's Mentored Clinical
   Scientist Research Career Development Award (K08CA266927).
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   Ahles TA, 2018, ANNU REV CLIN PSYCHO, V14, P425, DOI [10.1146/annurev-clinpsy-050817084903, 10.1146/annurev-clinpsy-050817-084903]
   [Anonymous], 2020, NCCN Clinical Practice Guidelines in Oncology: Survivorship
   [Anonymous], 2006, COMMON TERMINOLOGY C
   Bedillion MF, 2019, BREAST, V44, P73, DOI 10.1016/j.breast.2019.01.004
   Bell ML, 2018, J PATIENT-REP OUTCOM, V2, DOI 10.1186/s41687-018-0071-4
   Benedict RHB, 1998, CLIN NEUROPSYCHOL, V12, P43, DOI 10.1076/clin.12.1.43.1726
   Benedict RHB, 1998, J CLIN EXP NEUROPSYC, V20, P339, DOI 10.1076/jcen.20.3.339.822
   Bjordal K, 2000, EUR J CANCER, V36, P1796, DOI 10.1016/S0959-8049(00)00186-6
   Blatch-Jones AJ, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-022233
   Chan YT, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/9949777
   Cheng KJ, 2014, J ACUPUNCT MERIDIAN, V7, P105, DOI 10.1016/j.jams.2013.07.008
   Cramer H, 2016, SCI REP-UK, V6, DOI 10.1038/srep36760
   Cui JW, 2021, VET SCI, V8, DOI 10.3390/vetsci8080149
   Czajkowski SM, 2015, HEALTH PSYCHOL, V34, P971, DOI 10.1037/hea0000161
   Deng L., 1987, Chinese Acupuncture and Moxibustion Foreign Language Press
   Desai K, 2021, J ALTERN COMPLEM MED, V27, P1011, DOI 10.1089/acm.2021.0102
   Epstein AS, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.42482
   Ercoli LM, 2015, PSYCHO-ONCOLOGY, V24, P1360, DOI 10.1002/pon.3769
   Ferguson Robert J., 2024, JOURNAL OF CLINICAL ONCOLOGY, V42
   Franco-Rocha OY, 2023, J CANCER RES CLIN, V149, P12561, DOI 10.1007/s00432-023-05088-0
   Garland SN, 2019, JNCI-J NATL CANCER I, V111, P1323, DOI 10.1093/jnci/djz050
   Hamel LM, 2016, CANCER CONTROL, V23, P327, DOI 10.1177/107327481602300404
   Han XH, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/156489
   Hardy Sara J, 2018, Am Soc Clin Oncol Educ Book, V38, P795, DOI [10.1200/edbk_201179, 10.1200/EDBK_201179]
   Hassan M, 2023, HEALTH QUAL LIFE OUT, V21, DOI 10.1186/s12955-023-02095-0
   Henderson FME, 2019, HEALTH PSYCHOL OPEN, V6, DOI 10.1177/2055102919832234
   Hershman DL, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.41720
   Jacobs SR, 2007, J PAIN SYMPTOM MANAG, V33, P13, DOI 10.1016/j.jpainsymman.2006.06.011
   Janelsins MC, 2014, INT REV PSYCHIATR, V26, P102, DOI 10.3109/09540261.2013.864260
   KATZMAN R, 1983, AM J PSYCHIAT, V140, P734
   Kesler S, 2013, CLIN BREAST CANCER, V13, P299, DOI 10.1016/j.clbc.2013.02.004
   Kim RY, 2023, AM J RESP CRIT CARE, V207, P777, DOI 10.1164/rccm.202208-1590LE
   King S, 2015, FRONT ONCOL, V5, DOI 10.3389/fonc.2015.00072
   Koffel E, 2018, J GEN INTERN MED, V33, P955, DOI 10.1007/s11606-018-4390-1
   LAIRD NM, 1982, BIOMETRICS, V38, P963, DOI 10.2307/2529876
   Lange M, 2019, ANN ONCOL, V30, P1925, DOI 10.1093/annonc/mdz410
   Latte-Naor S, 2019, J ONCOL PRACT, V15, P7, DOI 10.1200/JOP.18.00554
   Lee B, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/670536
   Leung MCP, 2014, J NEUROIMMUNE PHARM, V9, P492, DOI 10.1007/s11481-014-9550-4
   Liou KT, 2020, CANCER-AM CANCER SOC, V126, P3042, DOI 10.1002/cncr.32847
   Liu CZ, 2006, NEUROSCI LETT, V393, P45, DOI 10.1016/j.neulet.2005.09.049
   Lv LQ, 2020, J ONCOL, V2020, DOI 10.1155/2020/3942439
   Lyu YR, 2022, INTEGR CANCER THER, V21, DOI 10.1177/15347354221098983
   Maeir T, 2023, DISABIL REHABIL, V45, P1056, DOI 10.1080/09638288.2022.2050954
   Mao Jun J, 2007, Acupunct Med, V25, P158
   Mao JJ, 2021, JAMA ONCOL, V7, P720, DOI 10.1001/jamaoncol.2021.0310
   Mao JJ, 2010, PRIMARY CARE, V37, P105, DOI 10.1016/j.pop.2009.09.010
   Mayo S, 2016, BONE MARROW TRANSPL, V51, P841, DOI 10.1038/bmt.2016.2
   Mayo SJ, 2021, SUPPORT CARE CANCER, V29, P2821, DOI 10.1007/s00520-020-05860-9
   Ng AH, 2021, JCO ONCOL PRACT, V17, P440, DOI 10.1200/OP.20.00625
   Oberste M, 2018, BMC CANCER, V18, DOI 10.1186/s12885-018-4992-3
   Orszaghova Z, 2021, FRONT MOL BIOSCI, V8, DOI 10.3389/fmolb.2021.770413
   Reid-Arndt Stephanie A, 2012, Complement Ther Clin Pract, V18, P26, DOI 10.1016/j.ctcp.2011.02.005
   Santos M.D., 2019, J. Clin. Oncol, V37, P11521, DOI [10.1200/JCO.2019.37.15suppl.11521, DOI 10.1200/JCO.2019.37.15SUPPL.11521]
   Savard J, 2016, JAMA ONCOL, V2, P1263, DOI 10.1001/jamaoncol.2016.2047
   Schmidt JE, 2016, J CANCER SURVIV, V10, P302, DOI 10.1007/s11764-015-0476-5
   Selamat MH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108002
   Shapiro AM, 1999, CLIN NEUROPSYCHOL, V13, P348, DOI 10.1076/clin.13.3.348.1749
   Teresi JA, 2022, MED CARE, V60, P95, DOI 10.1097/MLR.0000000000001664
   Tong TS, 2018, MED SCI MONITOR, V24, P2919, DOI 10.12659/MSM.909712
   Van Dyk K, 2021, JAMA-J AM MED ASSOC, V326, P1736, DOI 10.1001/jama.2021.13309
   Vogel S, 2017, INT J OSTEOPATH MED, V23, P2, DOI 10.1016/j.ijosm.2017.02.001
   Von Ah D, 2016, ONCOL NURS FORUM, V43, P602, DOI 10.1188/16.ONF.602-616
   Von Ah D, 2015, J PAIN SYMPTOM MANAG, V49, P697, DOI 10.1016/j.jpainsymman.2014.08.012
   Von Ah D, 2012, BREAST CANCER RES TR, V135, P799, DOI 10.1007/s10549-012-2210-6
   Wefel JS, 2011, LANCET ONCOL, V12, P703, DOI 10.1016/S1470-2045(10)70294-1
   Wei DM, 2011, NEURAL REGEN RES, V6, P2357, DOI 10.3969/j.issn.1673-5374.2011.30.007
   Zhong B., 1993, Essentials of Chinese Acupuncture
NR 69
TC 0
Z9 0
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1198-0052
EI 1718-7729
J9 CURR ONCOL
JI Curr. Oncol.
PD JAN
PY 2025
VL 32
IS 1
AR 27
DI 10.3390/curroncol32010027
PG 16
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA T4Z4V
UT WOS:001405104200001
PM 39851943
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU McPhail, P
   Sandhu, H
   Dale, J
   Stewart-Brown, S
AF McPhail, P.
   Sandhu, H.
   Dale, J.
   Stewart-Brown, S.
TI Acupuncture in hospice settings: A qualitative exploration of patients'
   experiences
SO EUROPEAN JOURNAL OF CANCER CARE
LA English
DT Article
DE acupuncture; grounded theory; hospice; qualitative; well-being
ID PALLIATIVE CARE; SYMPTOM MANAGEMENT; CANCER; COMPLEMENTARY; INTERVENTION
AB Whilst acupuncture has the potential to impact on many aspects of health and well-being, including end-of-life care, there is little research regarding patients' experiences of its effects within the context of palliative care in hospice settings. The aim of this study was to address this gap, by exploring patients' experiences of acupuncture within this setting. In-depth, semi-structured interviews were conducted with a sample of eighteen patients who had received acupuncture as part of hospice care. Transcription of data, with thematic analysis, identified two overarching themes: (1) participant perceptions of the effects of acupuncture including pain control, improved physical and emotional health, spiritual well-being and awareness of health as a holistic phenomenon; and (2) factors which participants believed enabled acupuncture to have these effects including the quality of the practitioner relationship, engagement of participants in the process of their treatment and prior expectations that acupuncture could work. Acupuncture was found to be a highly acceptable, accessible and popular treatment with positive holistic effects reported across the domains of physical, mental and spiritual health and no serious adverse effects. By enabling awareness ofthe holistic nature of health and well-being, acupuncture was experienced as havingthe potential to contribute to a better death, an emergent theory that needs testing in further studies. In the meanwhile, the results of this study offer encouragement to hospices currently providing or considering investing in acupuncture provision.
C1 [McPhail, P.] Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry, W Midlands, England.
   [Dale, J.] Univ Warwick, Warwick Med Sch, Div Hlth Sci, Primary Care, Coventry, W Midlands, England.
   [Stewart-Brown, S.] Univ Warwick, Warwick Med Sch, Div Hlth Sci, Publ Hlth, Coventry, W Midlands, England.
   [Sandhu, H.] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Div Hlth Sci, Coventry, W Midlands, England.
C3 University of Warwick; University of Warwick; University of Warwick;
   University of Warwick
RP McPhail, P (corresponding author), Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry, W Midlands, England.
EM paulahearle@hotmail.co.uk
OI Dale, Jeremy/0000-0001-9256-3553; Sandhu, Harbinder/0000-0003-1522-8078
CR Alfred A, 2011, AUST FAM PHYSICIAN, V40, P718
   Alraek T, 2001, COMPLEMENT THER MED, V9, P219, DOI 10.1054/ctim.2001.0482
   Bonafede M., 2004, NEGOTIATING ALTERNAT
   Braun V., 2006, Qualitative Research in Psychology, V3, P77, DOI [DOI 10.1080/14780887.2020.1769238, DOI 10.1191/1478088706QP063OA]
   Busuyi S., 2014, AM J HOSP PALLIAT ME, V31, P254
   Cassidy CM, 1998, J ALTERN COMPLEM MED, V4, P189, DOI 10.1089/acm.1998.4.189
   Dean-Clower E, 2010, ACUPUNCTURE PALLIATI
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Glaser B., 1978, THEORETICAL SENSITIV
   Gould A, 2001, J ALTERN COMPLEM MED, V7, P261, DOI 10.1089/107555301300328133
   Hu C., 2016, ACUPUNCTURE PAIN MAN
   Hughes JG, 2007, COMPLEMENT THER MED, V15, P101, DOI 10.1016/j.ctim.2006.09.008
   Hughes JG, 2009, COMPLEMENT THER MED, V17, P269, DOI 10.1016/j.ctim.2009.06.002
   King MB, 2009, BMC HEALTH SERV RES, V9, DOI 10.1186/1472-6963-9-116
   Korak LE, 2008, AM J HOSP PALLIAT ME, V25, P463, DOI 10.1177/1049909108322292
   Leng G, 1999, PALLIATIVE MED, V13, P163, DOI 10.1191/026921699676243035
   Leng G, 2013, ACUPUNCT MED, V31, P16, DOI 10.1136/acupmed-2012-010230
   Lian WL, 2014, CHIN J INTEGR MED, V20, P136, DOI 10.1007/s11655-013-1439-1
   Liang YD, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-345
   Lim JTW, 2011, ACUPUNCT MED, V29, P173, DOI 10.1136/aim.2011.004044
   MacPherson H, 2006, J ALTERN COMPLEM MED, V12, P873, DOI 10.1089/acm.2006.12.873
   Monod S, 2011, J GEN INTERN MED, V26, P1345, DOI 10.1007/s11606-011-1769-7
   Nelson JP, 2006, J HOLIST NURS, V24, P152, DOI 10.1177/0898010105282524
   Oneschuk D, 2007, SUPPORT CARE CANCER, V15, P939, DOI 10.1007/s00520-007-0284-1
   Paterson C, 2004, J ALTERN COMPLEM MED, V10, P791
   Paterson C., 2010, European Journal of Oriental Medicine, V6, P36
   Price S, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/165891
   Romeo MJ, 2015, EXPLORE-NY, V11, P357, DOI 10.1016/j.explore.2015.06.001
   Standish LJ, 2008, AM J HOSP PALLIAT ME, V25, P298, DOI 10.1177/1049909108315916
   Tippens KM, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-293
   Towler P, 2013, SUPPORT CARE CANCER, V21, P2913, DOI 10.1007/s00520-013-1882-8
   Tuck CM, 2010, ACUPUNCT MED, V28, P46, DOI 10.1136/aim.2009.000687
   Wei-Ling L., 2013, CHINESE J INTEGRATED, V20
   Wu X., 2015, EFFECTIVENESS ACUPUN
NR 34
TC 10
Z9 12
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0961-5423
EI 1365-2354
J9 EUR J CANCER CARE
JI Eur. J. Cancer Care
PD MAR
PY 2018
VL 27
IS 2
AR e12802
DI 10.1111/ecc.12802
PG 9
WC Oncology; Health Care Sciences & Services; Nursing; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Health Care Sciences & Services; Nursing; Rehabilitation
GA GA4SH
UT WOS:000428321300039
PM 29323766
DA 2026-01-16
ER

PT J
AU Ben-Horin, I
   Kahan, P
   Ryvo, L
   Inbar, M
   Lev-Ari, S
   Geva, R
AF Ben-Horin, Idan
   Kahan, Peretz
   Ryvo, Larisa
   Inbar, Moshe
   Lev-Ari, Shahar
   Geva, Ravit
TI Acupuncture and Reflexology for Chemotherapy-Induced Peripheral
   Neuropathy in Breast Cancer
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE peripheral neuropathy; breast cancer; acupuncture; reflexology;
   chemotherapy
ID QUALITY-OF-LIFE; MANAGEMENT; THERAPY; PAIN
AB Background: Treatment of chemotherapy-induced peripheral neuropathy (CIPN), which affects approximately 30% to 40% of patients treated with neuropathy-causing agents, is mainly symptomatic. Currently available interventions are of little benefit. Study Design: This study was conducted as a retrospective analysis of the efficacy of acupuncture and reflexology in alleviating CIPN in breast cancer patients. Methods: Medical records of 30 consecutive breast cancer patients who received both chemotherapy and treatment for CIPN according to our Acupuncture and Reflexology Treatment for Neuropathy (ART-N) protocol between 2011 and 2012 were reviewed. Symptom severity was rated at baseline, during, and after treatment. Results: The records of 30 breast cancer patients who had been concomitantly treated with chemotherapy and ART-N for CIPN were retrieved. Two records were incomplete, leaving a total of 28 patients who were enrolled into the study. Twenty patients (71%) had sensory neuropathy, 7 (25%) had motor neuropathy, and 1 (4%) had both sensory and motor neuropathy. Only 2 (10%) of the 20 patients with grades 1 to 2 neuropathy still reported symptoms at 12 months since starting the ART-N protocol. All 8 patients who presented with grades 3 to 4 neuropathy were symptom-free at the 12-month evaluation. Overall, 26 patients (93%) had complete resolution of CIPN symptoms. Conclusion: The results of this study demonstrated that a joint protocol of acupuncture and reflexology has a potential to improve symptoms of CIPN in breast cancer patients. The protocol should be validated on a larger cohort with a control group. It also warrants testing as a preventive intervention.
C1 [Ben-Horin, Idan; Kahan, Peretz; Ryvo, Larisa; Inbar, Moshe; Lev-Ari, Shahar; Geva, Ravit] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center
RP Ben-Horin, I (corresponding author), Tel Aviv Sourasky Med Ctr, Div Oncol, 6 Weizman St, IL-6423906 Tel Aviv, Israel.
EM idanbh@tlvmc.gov.il
OI lev-ari, shahar/0000-0003-0187-9427
CR Bao T, 2011, PAIN RES TREAT, V2011, DOI 10.1155/2011/920807
   Cavaletti G, 2013, ANN ONCOL, V24, P454, DOI 10.1093/annonc/mds329
   Cavaletti G, 2010, NAT REV NEUROL, V6, P657, DOI 10.1038/nrneurol.2010.160
   Chaudhry V, 2003, NEUROLOGY, V60, P337, DOI 10.1212/01.WNL.0000043691.53710.53
   Cunningham JE, 2011, SUPPORT CARE CANCER, V19, P1473, DOI 10.1007/s00520-011-1231-8
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Ezzo JM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002285.pub2
   Grisold W, 2012, NEURO-ONCOLOGY, V14, P45, DOI 10.1093/neuonc/nos203
   Kuroi K, 2008, JPN J CLIN ONCOL, V38, P748, DOI 10.1093/jjco/hyn100
   Lee JJ, 2006, J CLIN ONCOL, V24, P1633, DOI 10.1200/JCO.2005.04.0543
   Lynch ME, 2014, J PAIN SYMPTOM MANAG, V47, P166, DOI 10.1016/j.jpainsymman.2013.02.018
   Molassiotis A, 2005, ANN ONCOL, V16, P655, DOI 10.1093/annonc/mdi110
   Park R, 2015, CANCER NURS, V38, P239, DOI 10.1097/NCC.0000000000000181
   Quasthoff S, 2002, J NEUROL, V249, P9, DOI 10.1007/PL00007853
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Stubblefield MD, 2009, J NATL COMPR CANC NE, V7, pS1, DOI 10.6004/jnccn.2009.0078
   Swarm RA, 2013, J NATL COMPR CANC NE, V11, P992, DOI 10.6004/jnccn.2013.0119
   Vickers AJ, 2004, J CLIN ONCOL, V22, P1731, DOI 10.1200/JCO.2004.04.102
   Windebank AJ, 2008, J PERIPHER NERV SYST, V13, P27, DOI 10.1111/j.1529-8027.2008.00156.x
   Wong Raimond, 2006, Acupunct Med, V24, P87
   Xu Wei-Ru, 2010, Zhongguo Zhen Jiu, V30, P457
   Yang XY, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/319734
NR 25
TC 32
Z9 38
U1 1
U2 27
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD SEP
PY 2017
VL 16
IS 3
BP 258
EP 262
DI 10.1177/1534735417690254
PG 5
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA FE0SL
UT WOS:000407929900002
PM 28150504
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tick, H
   Nielsen, A
   Pelletier, KR
   Bonakdar, R
   Simmons, S
   Glick, R
   Ratner, E
   Lemmon, RL
   Wayne, P
   Zador, V
AF Tick, Heather
   Nielsen, Arya
   Pelletier, Kenneth R.
   Bonakdar, Robert
   Simmons, Samantha
   Glick, Ronald
   Ratner, Emily
   Lemmon, Russell L.
   Wayne, Peter
   Zador, Veronica
CA Pain Task Force Acad Consortium
TI EVIDENCE-BASED NONPHARMACOLOGIC STRATEGIES FOR COMPREHENSIVE PAIN CARE:
   THE CONSORTIUM PAIN TASK FORCE WHITE PAPER
SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
LA English
DT Article
DE Non Surgical Pain Management; Public Health; Evidence-Based Practice in
   Health Care System; Acute Pain Management; Integrative Medicine; Chronic
   Pain Management
ID LOW-BACK-PAIN; COGNITIVE-BEHAVIORAL THERAPY; CHRONIC MUSCULOSKELETAL
   PAIN; RANDOMIZED CONTROLLED-TRIAL; ARTHROSCOPIC PARTIAL MENISCECTOMY;
   MINDFULNESS-BASED INTERVENTIONS; POLYUNSATURATED FATTY-ACIDS; ALEXANDER
   TECHNIQUE LESSONS; CHRONIC NEUROPATHIC PAIN; MENTAL-HEALTH DISORDERS
AB Medical pain management is in crisis; from the pervasiveness of pain to inadequate pain treatment, from the escalation of prescription opioids to an epidemic in addiction, diversion and overdose deaths. The rising costs of pain care and managing adverse effects of that care have prompted action from state and federal agencies including the DOD, VHA, NIH, FDA and CDC.
   There is pressure for pain medicine to shift away from reliance on opioids, ineffective procedures and surgeries toward comprehensive pain management that includes evidence-based nonpharmacologic options. This White Paper details the historical context and magnitude of the current pain problem including individual, social and economic impacts as well as the challenges of pain management for patients and a healthcare workforce engaging prevalent strategies not entirely based in current evidence. Detailed here is the evidence-base for nonpharmacologic therapies effective in postsurgical pain with opioid sparing, acute non-surgical pain, cancer pain and chronic pain. Therapies reviewed include acupuncture therapy, massage therapy, osteopathic and chiropractic manipulation, meditative movement therapies Tai chi and yoga, mind body behavioral interventions, dietary components and self-care/self-efficacy strategies.
   Transforming the system of pain care to a responsive comprehensive model necessitates that options for treatment and collaborative care must be evidence-based and include effective nonpharmacologic strategies that have the advantage of reduced risks of adverse events and addiction liability.
   The evidence demands a call to action to increase awareness of effective nonpharmacologic treatments for pain, to train healthcare practitioners and administrators in the evidence base of effective nonpharmacologic practice, to advocate for policy initiatives that remedy system and reimbursement barriers to evidence informed comprehensive pain care, and to promote ongoing research and dissemination of the role of effective nonpharmacologic treatments in pain, focused on the short- and long-term therapeutic and economic impact of comprehensive care practices.
C1 [Tick, Heather] Univ Washington, Sch Med, Dept Family Med, Seattle, WA 98195 USA.
   [Tick, Heather] Univ Washington, Sch Med, Dept Anesthesiol, Seattle, WA 98195 USA.
   [Tick, Heather] Univ Washington, Sch Med, Dept Pain Med, Seattle, WA 98195 USA.
   [Nielsen, Arya] Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY 10029 USA.
   [Pelletier, Kenneth R.] Univ Calif San Francisco, Sch Med, Dept Med, San Francisco, CA USA.
   [Bonakdar, Robert] Scripps Ctr Integrat Med, Dept Pain Management, La Jolla, CA USA.
   [Simmons, Samantha] Oregon Collaborat Integrat Med, Portland, OR USA.
   [Glick, Ronald] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
   [Glick, Ronald] Univ Pittsburgh, Sch Med, Dept Phys Med & Rehabil, Pittsburgh, PA USA.
   [Ratner, Emily] MedStar Montgomery Med Ctr, Integrat Med Initiat, Inst Innovat, MedStar Hlth, Washington, DC USA.
   [Lemmon, Russell L.] Univ Wisconsin, Dept Family Med & Community Hlth, Sch Med & Publ Hlth, Madison, WI USA.
   [Wayne, Peter] Brigham & Womens Hosp, Osher Ctr Integrat Med, 75 Francis St, Boston, MA 02115 USA.
   [Wayne, Peter] Harvard Med Sch, Boston, MA USA.
   [Zador, Veronica] Oakland Univ, Beaumont Hosp Integrat Med, William Beaumont Sch Med, Rochester, MI 48063 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of
   Washington; University of Washington Seattle; Icahn School of Medicine
   at Mount Sinai; University of California System; University of
   California San Francisco; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh; University
   of Wisconsin System; University of Wisconsin Madison; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard Medical School; Oakland University
RP Tick, H (corresponding author), Univ Washington, Sch Med, Dept Family Med, Seattle, WA 98195 USA.; Tick, H (corresponding author), Univ Washington, Sch Med, Dept Anesthesiol, Seattle, WA 98195 USA.; Tick, H (corresponding author), Univ Washington, Sch Med, Dept Pain Med, Seattle, WA 98195 USA.; Nielsen, A (corresponding author), Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY 10029 USA.
EM HTick@uw.edu; Arya.Nielsen@mountsinai.org
RI Tick, Heather/F-2184-2013; Nielsen, Arya/GXI-0466-2022
OI Tick, Heather/0000-0002-8903-2396; Nielsen, Arya/0000-0003-3370-9123
FU National Center for Complementary and Integrative Health [K24AT009282]
   Funding Source: NIH RePORTER; NCCIH NIH HHS [K24 AT009282] Funding
   Source: Medline
CR Abdulrazaq M, 2017, NUTRITION, V39-40, P57, DOI 10.1016/j.nut.2016.12.003
   Aboagye E, 2015, J REHABIL MED, V47, P167, DOI 10.2340/16501977-1910
   Ackerman SL, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/792042
   Acufinder.com, 2017, MUCH DOES AC TREATM
   Adams D, 2011, PEDIATRICS, V128, pE1575, DOI 10.1542/peds.2011-1091
   Agarwal KA, 2011, SURG ENDOSC, V25, P3805, DOI 10.1007/s00464-011-1793-z
   Agoston AM, 2016, CHILDREN-BASEL, V3, DOI 10.3390/children3040039
   AKIL H, 1984, ANNU REV NEUROSCI, V7, P223, DOI 10.1146/annurev.ne.07.030184.001255
   AL-Atiyyat N, 2017, INT J PALLIAT NURS, V23, P13, DOI 10.12968/ijpn.2017.23.1.13
   Al-Eisa ES, 2016, CLIN INTERV AGING, V11, P513, DOI 10.2147/CIA.S102892
   Alexander GC, 2012, JAMA-J AM MED ASSOC, V308, P1865, DOI 10.1001/jama.2012.14282
   Ali A, 2017, J PEDIATR-US, V183, P184, DOI 10.1016/j.jpeds.2016.12.053
   Aljebab F, 2016, ARCH DIS CHILD, V101, P365, DOI [10.1136/archdischild-2016-311535.57, 10.1136/archdischild-2015-309522, 10.1136/archdischild-2016-311535.57]
   Amat J, 2016, J NEUROSCI, V36, P153, DOI 10.1523/JNEUROSCI.3114-15.2016
   Anandacoomarasamy A, 2009, CURR OPIN RHEUMATOL, V21, P71, DOI 10.1097/BOR.0b013e32831bc0d7
   Andreae MH, 2015, J PAIN, V16, P1221, DOI 10.1016/j.jpain.2015.07.009
   Andronis L, 2017, APPL HEALTH ECON HEA, V15, P173, DOI 10.1007/s40258-016-0268-8
   Anheyer D, 2017, ANN INTERN MED, V166, P799, DOI 10.7326/M16-1997
   [Anonymous], 2017, Pain Assessment and Management Standards for Hospitals
   [Anonymous], PRESCR DRUG AB STRAT
   [Anonymous], UN TREATM CONFR RAC
   [Anonymous], 2017, PROGRAMME GRANTS APP
   [Anonymous], 2016, National Pain Strategy: A Comprehensive Population Health-Level Strategy for Pain
   [Anonymous], INTEGR CANC THER
   [Anonymous], 2010, AFMS News Letter
   Apostolova N, 2015, ANTIOXID REDOX SIGN, V22, P686, DOI 10.1089/ars.2014.5952
   Asadpour Rebecca, 2016, Adv Radiat Oncol, V1, P344, DOI [10.1016/j.adro.2016.08.002, 10.1016/j.adro.2016.08.002]
   Asher GN, 2010, J ALTERN COMPLEM MED, V16, P1097, DOI 10.1089/acm.2009.0451
   Bakhshani Nour Mohammad, 2015, Glob J Health Sci, V8, P142, DOI [10.5539/gjhs.v8n4p142, 10.5539/gjhs.v8n4p142]
   Ballantyne JC, 2016, JAMA-J AM MED ASSOC, V315, P2459, DOI 10.1001/jama.2016.6753
   Ballantyne JC, 2015, NEW ENGL J MED, V373, P2098, DOI 10.1056/NEJMp1507136
   Ballantyne JC, 2015, PHYS MED REH CLIN N, V26, P201, DOI 10.1016/j.pmr.2014.12.001
   Ballantyne JC, 2003, NEW ENGL J MED, V349, P1943, DOI 10.1056/NEJMra025411
   Bartels EM, 2015, OSTEOARTHR CARTILAGE, V23, P13, DOI 10.1016/j.joca.2014.09.024
   Becker WC, 2017, BMC FAM PRACT, V18, DOI 10.1186/s12875-017-0608-2
   Bennell KL, 2017, ANN INTERN MED, V166, P453, DOI 10.7326/M16-1714
   Bergqvist D, 2013, INT ANGIOL, V32, P1
   Bet PM, 2013, EUR NEUROPSYCHOPHARM, V23, P1443, DOI 10.1016/j.euroneuro.2013.05.001
   Bird JK, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070655
   Blackwell D.L., 2014, VITAL HLTH STAT, V10
   Blaser M.J., 2015, Missing microbes: How the overuse of antibiotics is fueling our modern plagues
   Bonnie RJ, 2017, PAIN MANAGEMENT AND THE OPIOID EPIDEMIC: BALANCING SOCIETAL AND INDIVIDUAL BENEFITS AND RISKS OF PRESCRIPTION OPIOID USE, P1, DOI 10.17226/24781
   Boyd C, 2016, PAIN MED, V17, P1757, DOI 10.1093/pm/pnw101
   Boyd C, 2016, PAIN MED, V17, P1553, DOI 10.1093/pm/pnw100
   Brady KT, 2016, AM J PSYCHIAT, V173, P18, DOI 10.1176/appi.ajp.2015.15020262
   Brantingham JW, 2013, J MANIP PHYSIOL THER, V36, P143, DOI 10.1016/j.jmpt.2013.04.001
   Brantingham JW, 2012, J MANIP PHYSIOL THER, V35, P127, DOI 10.1016/j.jmpt.2012.01.001
   Brantingham JW, 2011, J MANIP PHYSIOL THER, V34, P314, DOI 10.1016/j.jmpt.2011.04.002
   Braun LA, 2012, J THORAC CARDIOV SUR, V144, P1453, DOI 10.1016/j.jtcvs.2012.04.027
   Brill S, 2002, BRIT J ANAESTH, V89, P711, DOI 10.1093/bja/aef266
   BROWN A, 2012, GALLUP HEALTHWAYS
   Buckenmaier C, 2014, PAIN MED, V15, pS7, DOI 10.1111/pme.12384
   Büssing A, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/165410
   Büssing A, 2012, J PAIN, V13, P1, DOI 10.1016/j.jpain.2011.10.001
   Bujalska-Zadrozny M, 2017, EUR J PHARM SCI, V99, P113, DOI 10.1016/j.ejps.2016.11.020
   Bushnell MC, 2015, PAIN, V156, pS42, DOI 10.1097/01.j.pain.0000460347.77341.bd
   Callinan CE, 2017, J PAIN, V18, P360, DOI 10.1016/j.jpain.2016.11.001
   Cameron C, 2015, HEADACHE, V55, P221, DOI 10.1111/head.12601
   Campaign to End Chronic Pain in Women, 2010, CHRON PAIN WOM NEGL
   Campbell CI, 2010, AM J PUBLIC HEALTH, V100, P2541, DOI 10.2105/AJPH.2009.180646
   Carnes D, 2012, CLIN J PAIN, V28, P344, DOI 10.1097/AJP.0b013e31822ed2f3
   Casale R, 2017, CURR PAIN HEADACHE R, V21, DOI 10.1007/s11916-017-0615-y
   CASSEL EJ, 1982, NEW ENGL J MED, V306, P639, DOI 10.1056/NEJM198203183061104
   Cecchi F, 2010, CLIN REHABIL, V24, P26, DOI 10.1177/0269215509342328
   Centers for Medicare and Medicaid Services, 2016, NAT HLTH EXP 2015 HI
   Chaibi A, 2012, J HEADACHE PAIN, V13, P351, DOI 10.1007/s10194-012-0436-7
   Chaibi A, 2011, J HEADACHE PAIN, V12, P127, DOI 10.1007/s10194-011-0296-6
   Chen JH, 2016, JAMA INTERN MED, V176, P259, DOI 10.1001/jamainternmed.2015.6662
   Cheng F, 2010, CAN FAM PHYSICIAN, V56, pE323
   Cherkin DC, 2017, JAMA-J AM MED ASSOC, V317, P642, DOI 10.1001/jama.2016.17814
   Cherkin DC, 2003, ANN INTERN MED, V138, P898, DOI 10.7326/0003-4819-138-11-200306030-00011
   Chibnall JT, 2006, SPINE, V31, P1272, DOI 10.1097/01.brs.0000217584.79528.9b
   Chien TJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180918
   Chirico A, 2016, J CELL PHYSIOL, V231, P275, DOI 10.1002/jcp.25117
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Chiu HY, 2016, PAIN PHYSICIAN, V19, pE97, DOI 10.36076/ppj/2016.19.e97
   Chou R, 2004, J PAIN SYMPTOM MANAG, V28, P140, DOI 10.1016/j.jpainsymman.2004.05.002
   Chou R., 2016, Noninvasive Treatments for Low Back Pain
   Chou R, 2017, ANN INTERN MED, V166, P493, DOI 10.7326/M16-2459
   Chou R, 2017, ANN INTERN MED, V166, P480, DOI 10.7326/M16-2458
   Chou R, 2016, J PAIN, V17, P131, DOI 10.1016/j.jpain.2015.12.008
   Choy EHS, 2015, NAT REV RHEUMATOL, V11, P513, DOI 10.1038/nrrheum.2015.56
   Coeytaux RR, 2016, HEADACHE, V56, P1238, DOI 10.1111/head.12857
   Cohen MM, 2017, MED J AUSTRALIA, V206, P494, DOI 10.5694/mja16.00771
   Cohen SP, 2017, BMJ-BRIT MED J, V358, DOI 10.1136/bmj.j3221
   Cooper MA, 2017, J PERIPHER NERV SYST, V22, P39, DOI 10.1111/jns.12199
   Coq JO, 2009, EXP NEUROL, V220, P234, DOI 10.1016/j.expneurol.2009.08.008
   Corbin Lisa, 2005, Cancer Control, V12, P158
   Corr TE, 2017, ADDICTION, V112, P1590, DOI 10.1111/add.13842
   Costhelper health, 2017, MUCH DOES CHIR COST
   Costhelper health, 2017, MUCH DOES BACK SURG
   Cramer H, 2012, CURR ONCOL, V19, pE343, DOI 10.3747/co.19.1016
   Cramer H, 2016, COMPLEMENT THER MED, V25, P178, DOI 10.1016/j.ctim.2016.02.015
   Cramer H, 2015, AM J EPIDEMIOL, V182, P281, DOI 10.1093/aje/kwv071
   Cramer H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075515
   Cramer H, 2013, CLIN J PAIN, V29, P450, DOI 10.1097/AJP.0b013e31825e1492
   Crawford C, 2016, PAIN MED, V17, P1353, DOI 10.1093/pm/pnw099
   Crawford P, 2017, MED ACUPUNCT, V29, P229, DOI 10.1089/acu.2017.1234
   Cruz-Díaz D, 2016, DISABIL REHABIL, V38, P1300, DOI 10.3109/09638288.2015.1090485
   Cunningham JL, 2017, J PAIN RES, V10, P311, DOI 10.2147/JPR.S123487
   Daily JW, 2016, J MED FOOD, V19, P717, DOI 10.1089/jmf.2016.3705
   Daily JW, 2015, PAIN MED, V16, P2243, DOI 10.1111/pme.12853
   Dancel R, 2017, REV RECENT CLIN TRIA, V12, P277, DOI 10.2174/1574887112666170816151232
   Davis MA, 2017, J AM BOARD FAM MED, V30, P407, DOI 10.3122/jabfm.2017.04.170112
   Davis R, 2017, J ALTERN COMPLEM MED, V23, P499, DOI 10.1089/acm.2017.29032.rjd
   Fernandes ACBDCJ, 2017, J ORAL FACIAL PAIN H, V31, P225, DOI 10.11607/ofph.1719
   de Oliveira DL, 2017, J ENDOCRINOL, V234, pR23, DOI 10.1530/JOE-16-0514
   Demarest SP, 2015, ENDOCR PRACT, V21, P190, DOI 10.4158/EP14339.RA
   Demirkaya S, 2001, HEADACHE, V41, P171, DOI 10.1046/j.1526-4610.2001.111006171.x
   Derry S, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008609.pub2
   Deshpande A, 2015, CAN FAM PHYSICIAN, V61, pE372
   Deyo RA, 2009, J AM BOARD FAM MED, V22, P62, DOI 10.3122/jabfm.2009.01.080102
   Dimitrova A, 2017, J ALTERN COMPLEM MED, V23, P164, DOI 10.1089/acm.2016.0155
   Dingemann J, 2017, HNO, V65, pS73, DOI 10.1007/s00106-016-0289-5
   Dion Liza, 2011, Int J Ther Massage Bodywork, V4, P2
   Dixon KE, 2007, HEALTH PSYCHOL, V26, P241, DOI 10.1037/0278-6133.26.3.241
   Dodds KN, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.168
   Donahue K, 2012, 2900200164 RTIUNC AG
   Doux JD, 2005, MED HYPOTHESES, V65, P389, DOI 10.1016/j.mehy.2004.12.021
   Dowell Deborah, 2016, JAMA, V315, P1624, DOI [10.15585/mmwr.rr6501e1, 10.1001/jama.2016.1464]
   Dueñas M, 2016, J PAIN RES, V9, P457, DOI 10.2147/JPR.S105892
   Edwards RR, 2008, J BEHAV MED, V31, P379, DOI 10.1007/s10865-008-9160-9
   EISENBERG DM, 1993, NEW ENGL J MED, V328, P246, DOI 10.1056/NEJM199301283280406
   Eisenberger NI, 2003, SCIENCE, V302, P290, DOI 10.1126/science.1089134
   Elden H, 2008, BMC COMPLEM ALTERN M, V8, DOI 10.1186/1472-6882-8-34
   Ernst E, 2003, RHEUMATOLOGY, V42, P1101, DOI 10.1093/rheumatology/keg306
   Ernst E, 2001, AM J MED, V110, P481, DOI 10.1016/S0002-9343(01)00651-9
   Evidence Development and Standards Branch Health Quality Ontario, 2014, Ont Health Technol Assess Ser, V14, P1
   FAIR Health, 2016, OP CRIS PRIV INS OP
   FAIR Health, 2016, IMP OP CRIS HEALTHC
   Fields HL, 2015, TRENDS NEUROSCI, V38, P217, DOI 10.1016/j.tins.2015.01.002
   Florence CS, 2016, MED CARE, V54, P901, DOI 10.1097/MLR.0000000000000625
   Fransen M, 2014, COCHRANE DB SYST REV, V2014
   Fransen M, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004376.pub3
   Fritz JM, 2014, SPINE J, V14, P1611, DOI 10.1016/j.spinee.2013.09.044
   Gaffey Andrew, 2015, JBI Database System Rev Implement Rep, V13, P59, DOI [10.11124/jbisrir-2015-1684, 10.11124/jbisrir-2015-1684]
   Gallagher LM, 2018, AM J HOSP PALLIAT ME, V35, P250, DOI 10.1177/1049909117696723
   Gaskin DJ, 2012, J PAIN, V13, P715, DOI 10.1016/j.jpain.2012.03.009
   Geller Jeffrey S, 2015, Glob Adv Health Med, V4, P27, DOI [10.7453/gahmj.2015.057, 10.7453/gahmj.2015.057]
   Gerrits MMJG, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-187
   Giacobbi PR Jr, 2015, PAIN MANAG NURS, V16, P792, DOI 10.1016/j.pmn.2015.01.003
   Gilbert JA, 2016, NATURE, V535, P94, DOI 10.1038/nature18850
   Glombiewski JA, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/962741
   Goetzel RZ, 2007, CLIN INTERV AGING, V2, P117, DOI 10.2147/ciia.2007.2.1.117
   Goetzel RZ, 2016, J OCCUP ENVIRON MED, V58, P9, DOI 10.1097/JOM.0000000000000632
   Goetzel RZ, 2004, J OCCUP ENVIRON MED, V46, P398, DOI 10.1097/01.jom.0000121151.40413.bd
   Goetzel RZ, 2003, J OCCUP ENVIRON MED, V45, P5, DOI 10.1097/00043764-200301000-00007
   Goetzel RZ, 2001, J OCCUP ENVIRON MED, V43, P10, DOI 10.1097/00043764-200101000-00003
   Goldberg H, 2015, JAMA-J AM MED ASSOC, V313, P1915, DOI 10.1001/jama.2015.4468
   Green JA, 2014, P NUTR SOC, V73, P278, DOI 10.1017/S0029665113003935
   2017, NAT REV DIS PRIMERS, V3, DOI [10.1038/nrdp.2017.41, DOI 10.1038/NRDP.2017.40, 10.1038/nrdp.2017.40]
   Grissa MH, 2016, AM J EMERG MED, V34, P2112, DOI 10.1016/j.ajem.2016.07.028
   Grol-Prokopczyk H, 2017, PAIN, V158, P313, DOI 10.1097/j.pain.0000000000000762
   Gross A., 2015, COCHRANE DB SYST REV, V2015, DOI DOI 10.1002/14651858.CD004249.PUB4
   Grossmeier J, 2016, J OCCUP ENVIRON MED, V58, P16, DOI 10.1097/JOM.0000000000000631
   Guh DP, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-88
   Gureje O, 1998, JAMA-J AM MED ASSOC, V280, P147, DOI 10.1001/jama.280.2.147
   Guy GP Jr, 2017, MMWR-MORBID MORTAL W, V66, P697, DOI 10.15585/mmwr.mm6626a4
   Hall A, 2017, PHYS THER, V97, P227, DOI 10.2522/ptj.20160246
   Haller H, 2017, ACTA ONCOL, V56, P1665, DOI 10.1080/0284186X.2017.1342862
   Hardt J, 2008, PAIN MED, V9, P803, DOI 10.1111/j.1526-4637.2008.00425.x
   Haun Jolie N, 2009, Int J Ther Massage Bodywork, V2, P7
   Hearing C M, 2016, Curr Behav Neurosci Rep, V3, P350, DOI [10.1007/s40473-016-0089-y, 10.1007/s40473-016-0089-y]
   Herman PM, 2017, SPINE, V42, P1511, DOI 10.1097/BRS.0000000000002344
   Herman Patricia M, 2013, Glob Adv Health Med, V2, P56, DOI 10.7453/gahmj.2013.002
   Herman PM, 2008, ALTERN THER HEALTH M, V14, P32
   Hesse T, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/508958
   Hill KP, 2015, JAMA-J AM MED ASSOC, V313, P2474, DOI 10.1001/jama.2015.6199
   Ho RST, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09856-0
   Hoffman HG, 2011, ANN BEHAV MED, V41, P183, DOI 10.1007/s12160-010-9248-7
   Holistic Medicine Health Library, 2017, FELD
   Hong S, 2016, J PHYS THER SCI, V28, P218, DOI [10.1589/jpts.28.2171, 10.1589/jpts.28.218, 10.1589/jpts.28.2171]
   Howard RF, 2003, JAMA-J AM MED ASSOC, V290, P2464, DOI 10.1001/jama.290.18.2464
   howmuchisit.org, 2017, MUCH DO PIL CLASS CO
   Huang KC, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001566
   Huang S, 2017, J ANESTH, V31, P58, DOI 10.1007/s00540-015-2057-1
   Hughes D, 2008, ONCOL NURS FORUM, V35, P431, DOI 10.1188/08.ONF.431-442
   Huguet A, 2008, J PAIN, V9, P226, DOI 10.1016/j.jpain.2007.10.015
   Hussain SM, 2017, ARTHRITIS RES THER, V19, DOI 10.1186/s13075-017-1242-z
   Institute of Medicine Committee on Advancing Pain Research Care and Education., 2011, REL PAIN AM BLUEPR T
   Jacobs TL, 2011, PSYCHONEUROENDOCRINO, V36, P664, DOI 10.1016/j.psyneuen.2010.09.010
   Jacobson AF, 2016, J ALTERN COMPLEM MED, V22, P563, DOI 10.1089/acm.2016.0038
   Jan AL, 2017, EMERG MED AUSTRALAS, V29, P490, DOI 10.1111/1742-6723.12832
   Jane SW, 2011, PAIN, V152, P2432, DOI 10.1016/j.pain.2011.06.021
   Janke EA, 2007, J REHABIL RES DEV, V44, P245, DOI 10.1682/JRRD.2006.06.0060
   Jimenez N, 2011, J PAIN, V12, P511, DOI 10.1016/j.jpain.2010.12.002
   Jindal V, 2008, J PEDIAT HEMATOL ONC, V30, P431, DOI 10.1097/MPH.0b013e318165b2cc
   Johannes CB, 2010, J PAIN, V11, P1230, DOI 10.1016/j.jpain.2010.07.002
   *JOINT COMM, 2015, CLAR PAIN MAN STAND
   Jones A, 2016, SAO PAULO MED J, V134, P366, DOI 10.1590/1516-3180.20161344T1
   KABATZINN J, 1985, J BEHAV MED, V8, P163, DOI 10.1007/BF00845519
   Kabouridis PS, 2015, J CLIN INVEST, V125, P956, DOI 10.1172/JCI76308
   Kan LD, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/6016532
   Kandil Enas, 2017, J Anesth Clin Res, V8, DOI [10.4172/2155-6148.1000697, 10.4172/2155-6148.1000697]
   Kaspin LC, 2013, POPUL HEALTH MANAG, V16, P14, DOI 10.1089/pop.2012.0006
   Katz N, 2009, CLIN J PAIN, V25, P170, DOI 10.1097/AJP.0b013e3181850df6
   Kearns MC, 2012, DEPRESS ANXIETY, V29, P833, DOI 10.1002/da.21997
   Keehan SP, 2017, HEALTH AFFAIR, V36, P553, DOI 10.1377/hlthaff.2016.1627
   Kekecs Z, 2014, ANESTH ANALG, V119, P1407, DOI 10.1213/ANE.0000000000000466
   Kennedy DJ, 2015, PAIN MED, V16, P1500, DOI 10.1111/pme.12833
   Kennedy J, 2014, J PAIN, V15, P979, DOI 10.1016/j.jpain.2014.05.009
   Kiecolt-Glaser JK, 2010, PSYCHOSOM MED, V72, P365, DOI 10.1097/PSY.0b013e3181dbf489
   King S, 2011, PAIN, V152, P2729, DOI 10.1016/j.pain.2011.07.016
   King W, 2015, PAIN MED, V16, P257, DOI 10.1111/pme.12630
   Kise NJ, 2016, BMJ-BRIT MED J, V354, DOI 10.1136/bmj.i3740
   Kligler B, 2018, PAIN MED, V19, P393, DOI 10.1093/pm/pnx134
   Kligler B, 2011, AM J MANAG CARE, V17, P779
   Kong LJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep25325
   Koopman C, 2002, J OCCUP ENVIRON MED, V44, P14, DOI 10.1097/00043764-200201000-00004
   Korzenik J, 2017, MED CLIN N AM, V101, P943, DOI 10.1016/j.mcna.2017.04.009
   Kozlowski LJ, 2014, PAIN MANAG NURS, V15, P22, DOI 10.1016/j.pmn.2012.04.003
   Kramer BJ, 2002, ARTHRIT RHEUM-ARTHR, V47, P588, DOI 10.1002/art.10795
   Kranenburg HA, 2017, MUSCULOSKEL SCI PRAC, V28, P32, DOI 10.1016/j.msksp.2017.01.008
   Kukimoto Y, 2017, PAIN MANAG NURS, V18, P378, DOI 10.1016/j.pmn.2017.09.001
   Ladas EJ, 2010, SUPPORT CARE CANCER, V18, P1487, DOI 10.1007/s00520-010-0926-6
   Lafferty WE, 2006, AM J MANAG CARE, V12, P397
   Lakhan SE, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0038-8
   Lamplot JD, 2016, BONE JOINT J, V98B, P934, DOI 10.1302/0301-620X.98B7.37410
   Langevin HM, 2013, J CELL BIOCHEM, V114, P1714, DOI 10.1002/jcb.24521
   Langevin HM, 2006, MED HYPOTHESES, V66, P1074, DOI 10.1016/j.mehy.2005.12.032
   Langevin HM, 2002, FASEB J, V16, P872, DOI 10.1096/fj.01-0925fje
   Langhorst J, 2015, J CROHNS COLITIS, V9, P86, DOI 10.1093/ecco-jcc/jju007
   Langhorst J, 2013, RHEUMATOL INT, V33, P193, DOI 10.1007/s00296-012-2360-1
   Lantz RC, 2007, PHYTOMEDICINE, V14, P123, DOI 10.1016/j.phymed.2006.03.003
   Lauche R, 2017, RHEUMATOL INT, V37, P1145, DOI 10.1007/s00296-017-3744-z
   Lee CE, 2017, HOLIST NURS PRACT, V31, P260, DOI 10.1097/HNP.0000000000000220
   Lee JH, 2016, J MUSIC THER, V53, P430, DOI 10.1093/jmt/thw012
   Lee SH, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/3549878
   Lee SH, 2015, INTEGR CANCER THER, V14, P297, DOI 10.1177/1534735415572885
   Lee YH, 2012, ARCH MED RES, V43, P356, DOI 10.1016/j.arcmed.2012.06.011
   Lei X, 2017, J BIOL CHEM, V292, P14836, DOI [10.1074/jbc.M116.766808, 10.1074/jbc.m116.766808]
   Li JY, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1669-4
   Li L, 2017, AM J TRANSL RES, V9, P3867
   Li Xiuxia, 2017, Pain Physician, V20, pE883
   Li Y, 2009, HEADACHE, V49, P805, DOI 10.1111/j.1526-4610.2009.01424.x
   Lin CWC, 2011, EUR SPINE J, V20, P1024, DOI 10.1007/s00586-010-1676-3
   Lin Hui-Ting, 2016, J Phys Ther Sci, V28, P2961, DOI 10.1589/jpts.28.2961
   Lin XF, 2016, J BONE JOINT SURG AM, V98, P1578, DOI 10.2106/JBJS.15.00620
   Lind BK, 2010, J ALTERN COMPLEM MED, V16, P411, DOI 10.1089/acm.2009.0261
   Linde K, 2016, COCHRANE DB SYST REV, V2016
   Linde K, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001218.pub3
   Lippe PM, 2010, PAIN MED, V11, P1447, DOI 10.1111/j.1526-4637.2010.00961.x
   Liu HS, 2013, POPUL HEALTH MANAG, V16, P1, DOI 10.1089/pop.2011.0108
   Liu XL, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/657809
   Loeser J.D., 2012, PAIN CLIN UPDATES, V20, P1
   Loseth GE, 2014, FRONT BEHAV NEUROSCI, V8, DOI 10.3389/fnbeh.2014.00430
   Loskotova A, 2017, BURNS, V43, P1782, DOI 10.1016/j.burns.2017.04.025
   Luciano JV, 2017, J PAIN, V18, P868, DOI 10.1016/j.jpain.2017.03.001
   Luctkar-Flude M, 2015, INTEGR CANCER THER, V14, P318, DOI 10.1177/1534735415572886
   Lundqvist LO, 2014, ARCH PHYS MED REHAB, V95, P1656, DOI 10.1016/j.apmr.2014.05.013
   Lurie JD, 2003, SPINE, V28, P616, DOI 10.1097/00007632-200303150-00018
   Machado GC, 2017, ANN RHEUM DIS, V76, P1269, DOI 10.1136/annrheumdis-2016-210597
   Mack KA, 2013, MMWR-MORBID MORTAL W, V62, P537
   MacPherson H, 2017, PAIN, V158, P784, DOI 10.1097/j.pain.0000000000000747
   MacPherson H, 2001, Acupunct Med, V19, P93
   MacPherson Hugh, 2005, Acupunct Med, V23, P112
   MacPherson H, 2015, ANN INTERN MED, V163, P653, DOI 10.7326/M15-0667
   MacPherson H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077438
   Maeda Y, 2017, BRAIN, V140, P914, DOI 10.1093/brain/awx015
   Mahrer NE, 2018, J PAIN, V19, P158, DOI 10.1016/j.jpain.2017.09.008
   Mai J, 2015, PHYS MED REH CLIN N, V26, P453, DOI 10.1016/j.pmr.2015.04.005
   Manchikanti L, 2017, PAIN PHYSICIAN, V20, pS3, DOI 10.36076/ppj.2017.s92
   Manchikanti L, 2012, ANN PALLIAT MED, V1, P2, DOI 10.3978/j.issn.2224-5820.2012.03.07
   Manchikanti L, 2012, PAIN PHYSICIAN, V15, pE969
   Manchikanti L, 2012, PAIN PHYSICIAN, V15, pES9
   Manchikanti L, 2011, PAIN PHYSICIAN, V14, pE177
   Mandel S, 2013, J BONE JOINT SURG AM, V95A, P961, DOI 10.2106/JBJS.L.00844
   Marks R, 2005, HEALTH PROMOT PRACT, V6, P148, DOI 10.1177/1524839904266792
   Marriage B, 2003, J AM DIET ASSOC, V103, P1029, DOI 10.1016/S0002-8223(03)00476-0
   Martin KR, 2017, THER ADV MUSCULOSKEL, V9, P131, DOI 10.1177/1759720X17708124
   Martin WJJM, 2011, ORAL SURG ORAL MED O, V111, P627, DOI 10.1016/j.tripleo.2011.01.033
   Marx W, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080867
   Marx W, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141119
   Mathews L, 2011, INDIAN J PALLIAT CAR, V17, P70, DOI 10.4103/0973-1075.76247
   Matzen Peter, 2003, Ugeskr Laeger, V165, P1431
   McLean K, 2016, INT J DRUG POLICY, V29, P19, DOI 10.1016/j.drugpo.2016.01.009
   McSherry T, 2018, J BURN CARE RES, V39, P278, DOI 10.1097/BCR.0000000000000589
   Mense S, 2008, DTSCH ARZTEBL INT, V105, P214, DOI 10.3238/artzebl.2008.0214
   Mezei L, 2011, J PAIN, V12, P1199, DOI 10.1016/j.jpain.2011.06.006
   Mikolasek M, 2018, INT J BEHAV MED, V25, P1, DOI 10.1007/s12529-017-9679-7
   Minihane AM, 2015, BRIT J NUTR, V114, P999, DOI 10.1017/S0007114515002093
   Mitchell JM, 2008, MED CARE, V46, P460, DOI 10.1097/MLR.0b013e31815dc5ae
   Mitchinson A, 2014, AM J HOSP PALLIAT ME, V31, P6, DOI 10.1177/1049909113476568
   Mitchinson AR, 2007, ARCH SURG-CHICAGO, V142, P1158, DOI 10.1001/archsurg.142.12.1158
   Mokdad AH, 2004, JAMA-J AM MED ASSOC, V291, P1238, DOI 10.1001/jama.291.10.1238
   Moore RA, 2017, COCHRANE DB SYST REV, V2017
   Morris G, 2016, MOL NEUROBIOL, V53, P1195, DOI 10.1007/s12035-015-9090-9
   Moulin DE, 2015, J PAIN, V16, P852, DOI 10.1016/j.jpain.2015.05.011
   Mulleners WM, 2015, CEPHALALGIA, V35, P51, DOI 10.1177/0333102414534325
   Murakami M, 2017, PAIN MED, V18, P551, DOI 10.1093/pm/pnw215
   Murillo ALP, 2017, CELLS TISSUES ORGANS, V203, P258, DOI 10.1159/000449407
   Murthy VH, 2016, NEW ENGL J MED, V375, P2413, DOI 10.1056/NEJMp1612578
   Musial F, 2011, FORSCH KOMPLEMENTMED, V18, P192, DOI 10.1159/000330714
   Myhill S, 2013, INT J CLIN EXP MED, V6, P1
   Nahin Richard L, 2016, Natl Health Stat Report, P1
   Nahin RL, 2016, MAYO CLIN PROC, V91, P1292, DOI 10.1016/j.mayocp.2016.06.007
   Nahin RL, 2015, J PAIN, V16, P1147, DOI 10.1016/j.jpain.2015.07.013
   Napadow V, 2006, NEUROIMAGE, V31, P520, DOI 10.1016/j.neuroimage.2005.12.017
   National Academies of Sciences Engineering and Medicine, 2017, CONS STUD REP HIGHL
   National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development, EP DEV EP COND INF
   National Institutes of Health National Institute on Drug Abuse, 2017, PAIN REL MOST REP RE
   Nestoriuc Y, 2008, J CONSULT CLIN PSYCH, V76, P379, DOI 10.1037/0022-006X.76.3.379
   Neustadt J, 2008, MOL NUTR FOOD RES, V52, P780, DOI 10.1002/mnfr.200700075
   Nguyen C., 2017, ANN INTERN MED, V166
   Nguyen C, 2017, ANN INTERN MED, V166, P547, DOI 10.7326/M16-1700
   Nielsen SM, 2017, SYST REV-LONDON, V6, DOI 10.1186/s13643-017-0458-y
   Nöthlings U, 2010, J DIABETES, V2, P112, DOI 10.1111/j.1753-0407.2010.00069.x
   O'Donnell M, 1998, CAN MED ASSOC J, V158, P1434
   Odell S, 2013, J PAIN RES, V6, P785, DOI 10.2147/JPR.S37434
   Okifuji A, 2015, J PAIN RES, V8, P399, DOI 10.2147/JPR.S55598
   Onakpoya IJ, 2017, INT J RHEUM DIS, V20, P420, DOI 10.1111/1756-185X.13069
   Oregon Health Authority Office of Clinical Services Improvement, 2016, BACK POL CHANG FACT
   Paice JA, 2016, J CLIN ONCOL, V34, P3325, DOI 10.1200/JCO.2016.68.5206
   Paige NM, 2017, JAMA-J AM MED ASSOC, V317, P1451, DOI 10.1001/jama.2017.3086
   Panksepp J., 2004, AFFECTIVE NEUROSCIEN, DOI DOI 10.1093/OSO/9780195096736.001.0001
   Park TW, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.h2698
   Parry T., 2006, The Business Value of Health: Linking CFOs to Health and Productivity
   Patel SJ, 2017, ADV MED EDUC PRACT, V8, P499, DOI 10.2147/AMEP.S138572
   Paulozzi LJ, 2015, MMWR SURVEILL SUMM, V64, P1, DOI 10.15585/mmwr.ss6409a1
   Paulozzi Leonard J., 2011, Morbidity and Mortality Weekly Report, V60, P60
   Pérez-Arredondo A, 2016, CLIN NEUROPHARMACOL, V39, P311, DOI 10.1097/WNF.0000000000000179
   Perkins K, 2017, J EVID-BASED INTEGR, V22, P156, DOI 10.1177/2156587216636747
   Perlman AI, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030248
   Piper S, 2016, MANUAL THER, V21, P18, DOI 10.1016/j.math.2015.08.011
   Plesh O, 2011, J OROFAC PAIN, V25, P25
   PORTENOY RK, 1986, PAIN, V25, P171, DOI 10.1016/0304-3959(86)90091-6
   Posadzki P, 2012, J PAIN SYMPTOM MANAG, V44, P95, DOI 10.1016/j.jpainsymman.2011.07.014
   Posadzki P, 2011, COMPLEMENT THER MED, V19, P281, DOI 10.1016/j.ctim.2011.07.004
   Posadzki P, 2011, CLIN J PAIN, V27, P648, DOI 10.1097/AJP.0b013e31821124a5
   Priester MA, 2016, J SUBST ABUSE TREAT, V61, P47, DOI 10.1016/j.jsat.2015.09.006
   Qaseem Amir, 2017, Ann Intern Med, V166, P514, DOI 10.7326/M16-2367
   Radcliff K, 2013, SPINE, V38, P279, DOI 10.1097/BRS.0b013e31827ec51f
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Raofi Saeid, 2006, Vital Health Stat 13, P1
   Rappaport SM, 2010, SCIENCE, V330, P460, DOI 10.1126/science.1192603
   Ratcliffe J, 2006, BRIT MED J, V333, P626, DOI 10.1136/bmj.38932.806134.7C
   Rehm CD, 2016, NUTRIENTS, V8, DOI 10.3390/nu8120804
   Reinstein AS, 2017, PAIN MED, V18, P169, DOI 10.1093/pm/pnv114
   Reyes-Gibby CC, 2002, PAIN, V95, P75, DOI 10.1016/S0304-3959(01)00375-X
   Rini C, 2015, PAIN, V156, P837, DOI 10.1097/j.pain.0000000000000121
   Rondón LJ, 2010, J PHYSIOL-LONDON, V588, P4205, DOI 10.1113/jphysiol.2010.197004
   Rosendahl J, 2016, BMC ANESTHESIOL, V16, DOI 10.1186/s12871-016-0292-0
   Rosenzweig S, 2010, J PSYCHOSOM RES, V68, P29, DOI 10.1016/j.jpsychores.2009.03.010
   Rudd RA, 2016, MMWR-MORBID MORTAL W, V64, P1378, DOI 10.15585/mmwr.mm6450a3
   Rudisill TM, 2016, ACCIDENT ANAL PREV, V96, P255, DOI 10.1016/j.aap.2016.08.001
   Ruskin DA, 2017, CLIN J PAIN, V33, P1019, DOI 10.1097/AJP.0000000000000490
   Ryan CG, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0179227
   Rygh LJ, 2005, PSYCHONEUROENDOCRINO, V30, P959, DOI 10.1016/j.psyneuen.2005.04.007
   Saatsaz S, 2016, COMPLEMENT THER CLIN, V24, P92, DOI 10.1016/j.ctcp.2016.05.014
   Salamh P, 2017, MUSCULOSKELET CARE, V15, P238, DOI 10.1002/msc.1166
   Sandberg O, 2015, ACTA ORTHOP, V86, P243, DOI 10.3109/17453674.2014.973328
   Saper RB, 2017, ANN INTERN MED, V167, P85, DOI 10.7326/M16-2579
   Saragiotto BT, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012230
   Saunders C., 1964, PRESCRIBERS J, V4, P68, DOI DOI 10.1177/014107680109400904
   Scherrer JF, 2016, PREV MED, V91, P110, DOI 10.1016/j.ypmed.2016.08.003
   Schoomaker E, 2014, PAIN MED, V15, pS4, DOI 10.1111/pme.12385
   Schuh-Hofer S, 2013, PAIN, V154, P1613, DOI 10.1016/j.pain.2013.04.046
   Schulz-Heik RJ, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1705-4
   Schwalfenberg GK, 2012, J ENVIRON PUBLIC HEA, V2012, DOI 10.1155/2012/727630
   Scott Jeffrey F, 2017, J Invest Dermatol, V137, P2078, DOI 10.1016/j.jid.2017.04.040
   Sen H, 2010, AGRI, V22, P145
   Serxner SA, 2003, J OCCUP ENVIRON MED, V45, P1196, DOI 10.1097/01.jom.0000095002.12772.6a
   Shah A, 2017, MMWR-MORBID MORTAL W, V66, P265, DOI 10.15585/mmwr.mm6610a1
   Sielski R, 2017, INT J BEHAV MED, V24, P25, DOI 10.1007/s12529-016-9572-9
   Singh G, 1999, J RHEUMATOL, V26, P18
   Singh G, 2000, Am J Ther, V7, P115, DOI 10.1097/00045391-200007020-00008
   Singh G, 1996, ARCH INTERN MED, V156, P1530, DOI 10.1001/archinte.156.14.1530
   Singla A, 2017, J NEUROSURG-SPINE, V26, P645, DOI 10.3171/2016.9.SPINE16484
   Skogberg O, 2017, J REHABIL MED, V49, P36, DOI 10.2340/16501977-2169
   Smith CA, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002962.pub3
   Social Security Admininistration Office of Retirement and Disablity Policy Office of Research Evaluation and Statistics, 2016, SSA PUBL, V13-11826
   Solloway MR, 2016, SYST REV-LONDON, V5, DOI 10.1186/s13643-016-0300-y
   Stanos S, 2016, POSTGRAD MED, V128, P502, DOI 10.1080/00325481.2016.1188319
   Su B, 2013, J APPL PHYSIOL, V115, P892, DOI 10.1152/japplphysiol.00053.2013
   Sui BD, 2013, POSTGRAD MED J, V89, P709, DOI 10.1136/postgradmedj-2012-131068
   Sullivan MD, 2006, ARCH INTERN MED, V166, P2087, DOI 10.1001/archinte.166.19.2087
   Sullivan MD, 2012, ARCH INTERN MED, V172, P433, DOI 10.1001/archinternmed.2011.2156
   Sullivan MD, 2010, PAIN, V151, P567, DOI 10.1016/j.pain.2010.08.036
   Sullivan MD, 2005, PAIN, V119, P95, DOI 10.1016/j.pain.2005.09.020
   Sun Y, 2008, BRIT J ANAESTH, V101, P151, DOI 10.1093/bja/aen146
   Tadros A, 2016, AM J DRUG ALCOHOL AB, V42, P550, DOI 10.1080/00952990.2016.1194851
   Tadros A, 2015, J EMERG MED, V49, P871, DOI 10.1016/j.jemermed.2015.06.035
   Tajerian M, 2017, NEURAL PLAST, V2017, DOI 10.1155/2017/2038573
   Tang NKY, 2015, SLEEP, V38, P1751, DOI 10.5665/sleep.5158
   Tauben D., 2015, NONOPIOID MEDICATION, V26
   Taylor P, 2014, PAIN PRACT, V14, P599, DOI 10.1111/papr.12116
   Tedesco D, 2017, JAMA SURG, V152, DOI 10.1001/jamasurg.2017.2872
   Terry R, 2011, PAIN MED, V12, P1808, DOI 10.1111/j.1526-4637.2011.01261.x
   Theadom A, 2015, COCHRANE DB SYST REV, V2015
   Thimmapuram J, 2017, J COMMUNITY HOSP INT, V7, DOI 10.1080/20009666.2016.1270806
   Thomas K J., 2005, Health Technol Assess, P1, DOI DOI 10.3310/HTA9320
   Thomas KJ, 2005, HEALTH TECHNOL ASSES, V9, pIII
   Thorlund JB, 2017, BMJ-BRIT MED J, V356, DOI 10.1136/bmj.j356
   Tick H, 2015, PAIN MED, V16, P2090, DOI 10.1111/pme.12818
   Tornbjerg SM, 2017, BRIT J SPORT MED, V51, DOI 10.1136/bjsports-2016-096456
   Treede RD, 2015, PAIN, V156, P1003, DOI 10.1097/j.pain.0000000000000160
   Trezza V, 2011, J NEUROSCI, V31, P6362, DOI 10.1523/JNEUROSCI.5492-10.2011
   Tsertsvadze A, 2014, J MANIP PHYSIOL THER, V37, P343, DOI 10.1016/j.jmpt.2014.05.001
   United States Congress Office of Technology Assessment, 1978, ASS EFF SAF MED TECH
   Unruh AM, 1996, PAIN, V65, P123, DOI 10.1016/0304-3959(95)00214-6
   *US FDA, 2017, FDA ED BLUEPR HLTH C
   US FDA, 2015, DRUG SAF COMM FDA ST
   van der Heijden MJE, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133608
   van der Velde G, 2016, SPINE J, V16, P1582, DOI 10.1016/j.spinee.2015.08.025
   van Ravesteyn LM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173397
   Veehof MM, 2016, COGN BEHAV THERAPY, V45, P5, DOI 10.1080/16506073.2015.1098724
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Viljoen E, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-20
   Volkow ND, 2011, JAMA-J AM MED ASSOC, V305, P1299, DOI 10.1001/jama.2011.401
   Von Korff M, 2005, PAIN, V113, P331, DOI 10.1016/j.pain.2004.11.010
   Von Korff M, 2004, PAIN, V109, P207, DOI 10.1016/j.pain.2004.02.019
   Von Zglinicki T, 2000, ANN NY ACAD SCI, V908, P99, DOI 10.1111/j.1749-6632.2000.tb06639.x
   VONKORFF M, 1988, PAIN, V32, P173, DOI 10.1016/0304-3959(88)90066-8
   Vos T, 2016, LANCET, V388, P1545, DOI 10.1016/s0140-6736(16)31678-6
   WALJEE AK, 2017, BMJ-BRIT MED J, V357, DOI DOI 10.1136/BMJ.J1415
   Wang QP, 2011, CNS DRUGS, V25, P847, DOI 10.2165/11595590-000000000-00000
   Wang R, 2017, ACUPUNCT MED, V35, P241, DOI 10.1136/acupmed-2016-011176
   Wang Z, 2015, ACTA ORTHOP, V86, P632, DOI 10.3109/17453674.2015.1028860
   Ward L, 2013, MUSCULOSKELET CARE, V11, P203, DOI 10.1002/msc.1042
   Watkins LR, 2009, TRENDS PHARMACOL SCI, V30, P581, DOI 10.1016/j.tips.2009.08.002
   Wayne PM, 2014, ARCH PHYS MED REHAB, V95, P2470, DOI 10.1016/j.apmr.2014.05.005
   Wearing SC, 2006, OBES REV, V7, P239, DOI 10.1111/j.1467-789X.2006.00251.x
   Weinhold B, 2006, ENVIRON HEALTH PERSP, V114, pA160, DOI 10.1289/ehp.114-a160
   Wells C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100402
   Wetherell JL, 2016, INT J GERIATR PSYCH, V31, P302, DOI 10.1002/gps.4330
   Wetherell JL, 2011, PAIN, V152, P2098, DOI 10.1016/j.pain.2011.05.016
   Whedon J, 2017, J ALTERN COMPLEM MED, V23, P264, DOI 10.1089/acm.2016.0369
   White Adrian, 2004, Acupunct Med, V22, P122
   Whitehurst DGT, 2011, PHYS THER, V91, P630, DOI 10.2522/ptj.20100239
   Wieland LS, 2017, COCHRANE DB SYST REV, V2017
   Wilhelmi BG, 2012, PAIN PHYSICIAN, V15, pES215
   Willich SN, 2006, PAIN, V125, P107, DOI 10.1016/j.pain.2006.06.006
   Wilson FA, 2015, J EVAL CLIN PRACT, V21, P952, DOI 10.1111/jep.12411
   Witt CM, 2006, PAIN, V125, P98, DOI 10.1016/j.pain.2006.05.013
   Witt CM, 2006, ARTHRITIS RHEUM-US, V54, P3485, DOI 10.1002/art.22154
   Won AS, 2017, CHILDREN-BASEL, V4, DOI 10.3390/children4070052
   Wonderling D, 2004, BMJ-BRIT MED J, V328, P747, DOI 10.1136/bmj.38033.896505.EB
   Wong D L, 1988, Pediatr Nurs, V14, P9
   Woodman JP, 2012, INT J CLIN PRACT, V66, P98, DOI 10.1111/j.1742-1241.2011.02817.x
   Woods B, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172749
   Woolf S.H., 2013, US health in international perspective: Shorter lives, poorer health, DOI 10.17226/13497
   Wu JY, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006064
   Wu MY, 2017, ARTHRITIS RES THER, V19, DOI 10.1186/s13075-017-1239-7
   Wu MS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150367
   Wu S, 2009, PEDIATR CRIT CARE ME, V10, P291, DOI 10.1097/PCC.0b013e318198afd6
   Xiang AF, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/3837194
   Xie Y, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-015735
   Xu QG, 2017, PAIN PHYSICIAN, V20, P229, DOI 10.36076/ppj.2017.243
   Xu Y, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1924-8
   Yamashita H, 2001, COMPLEMENT THER MED, V9, P98, DOI 10.1054/ctim.2001.0446
   Yamashita H, 2008, EVID-BASED COMPL ALT, V5, P391, DOI 10.1093/ecam/nem086
   Yamato TP, 2015, COCHRANE DB SYST REV, V2015
   Yang YX, 2010, GASTROENTEROLOGY, V139, P1115, DOI 10.1053/j.gastro.2010.08.023
   Yazdanshenas H, 2016, J AM GERIATR SOC, V64, P2116, DOI 10.1111/jgs.14302
   Ye QP, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/6421852
   Yeh CH, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/934670
   Yeh GY, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154678
   Yin P, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/480956
   Zaina F, 2016, SPINE, V41, pE857, DOI [10.1097/BRS.0000000000001635, 10.1002/14651858.CD010264.pub2]
   Zech N, 2017, EUR J PAIN, V21, P217, DOI 10.1002/ejp.933
   Zhao XF, 2012, TOP STROKE REHABIL, V19, P226, DOI 10.1310/tsr1903-226
   Zogopoulos P, 2013, FUND CLIN PHARMACOL, V27, P64, DOI 10.1111/fcp.12008
NR 463
TC 227
Z9 284
U1 4
U2 54
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-8307
EI 1878-7541
J9 EXPLORE-NY
JI Explore-J Sci. Heal.
PD MAY-JUN
PY 2018
VL 14
IS 3
BP 177
EP 211
DI 10.1016/j.explore.2018.02.001
PG 35
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA GM1GM
UT WOS:000437814100011
PM 29735382
OA hybrid
DA 2026-01-16
ER

PT J
AU Ding, YJ
   Cao, HZ
   Huang, Y
   Xue, H
   Cai, SQ
   Chen, XH
   Duan, ML
AF Ding, Yajun
   Cao, Hanzhong
   Huang, Ying
   Xue, Hong
   Cai, Shenquan
   Chen, Xiaohong
   Duan, Manlin
TI Fire Acupuncture Combined with Pulse Radiofrequency Relieves Tactile
   Allodynia in Rats with Postherpetic Neuralgia
SO INTERNATIONAL JOURNAL OF GENERAL MEDICINE
LA English
DT Article
DE postherpetic neuralgia; P13K/AKT; fire acupuncture; pulse radiofrequency
ID VARICELLA-ZOSTER-VIRUS; PROTEIN-KINASE B/AKT; NEUROPATHIC PAIN;
   HERPES-ZOSTER; CONTRIBUTES; ACTIVATION; 3-KINASE; MODEL
AB Background: Postherpetic neuralgia (PHN) remains challenging to treat, with 40%-50% of patients experiencing inadequate pain relief despite comprehensive interventions. Neuromodulation techniques such as pulsed radiofrequency (RF) and traditional methods such as fire acupuncture (FA) are increasingly used for PHN. This study investigated the combined effect of FA and RF on tactile allodynia in a rat model of PHN and explored its underlying mechanisms. Methods: Adult male rats were randomly divided into: Control, PHN, FA, RF, and combined FA_RF groups. PHN was induced by varicella-zoster virus inoculation. FA and/or RF interventions began on Day 15. Pain behavior was assessed via mechanical allodynia and thermal hyperalgesia tests. On Day 37, spinal cord tissues and cerebrospinal fluid were collected to evaluate astrocyte and microglial activation, neuronal apoptosis, expression of Insulin-Like Growth Factor 2 (IGF2), Peripheral Myelin Protein 2 (PMP2), Claudin-19 (CLDN19), Homeobox C8 (HOXC8), and levels of interleukin-1(3 (IL-1(3), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha). The role of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway was verified using a PI3K/AKT agonist. Results: The results revealed that mechanical allodynia thresholds decreased on Day 8 post-inoculation. Compared to the PHN group, FA_RF combination significantly increased mechanical thresholds and prolonged thermal hyperalgesia latency, with superior effects versus FA or RF alone. The FA_RF group showed increased spinal IGF2, PMP2, and CLDN19 expression, decreased HOXC8, reduced astrocyte activation, and modulated cytokine levels (IL-1(3, IL-6, TNF-alpha, IL-10). The PI3K/AKT agonist reversed the analgesic effects of FA_RF. Conclusion: Combined fire acupuncture and pulsed radiofrequency alleviates tactile allodynia in PHN rats, possibly by inhibiting spinal astrocyte activation, modulating inflammatory responses, and promoting nerve repair via IGF2, PMP2, and CLDN19 expression. The PI3K/AKT pathway may be critically involved in this analgesic mechanism.
C1 [Ding, Yajun; Duan, Manlin] Nanjing Univ Chinese Med, Jinling Clin Med Coll, Dept Anesthesiol, Nanjing 210002, Peoples R China.
   [Ding, Yajun; Cao, Hanzhong; Chen, Xiaohong] Nantong Univ, Tumor Hosp, Nantong Tumor Hosp, Nantong 226361, Peoples R China.
   [Huang, Ying; Cai, Shenquan] Nanjing Univ, Nanjing Drum Tower Hosp, Dept Pain Med, Affiliated Hosp,Med Sch, Nanjing 210008, Peoples R China.
   [Xue, Hong] Xuzhou Med Univ, Affiliated Huaian Hosp, Dept Anesthesiol, Huaian 223002, Peoples R China.
   [Xue, Hong] Huaian Second Peoples Hosp, Huaian 223002, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nantong University; Nanjing
   University; Xuzhou Medical University
RP Ding, YJ; Duan, ML (corresponding author), Nanjing Univ Chinese Med, Jinling Clin Med Coll, Dept Anesthesiol, Nanjing 210002, Peoples R China.; Ding, YJ (corresponding author), Nantong Univ, Tumor Hosp, Nantong Tumor Hosp, Nantong 226361, Peoples R China.
EM huangy0808@nju.edu.cn; dml1200@126.com
OI Ding, Yajun/0009-0008-2034-5678
FU Nanjing Drum Tower Hospital integrated traditional Chinese and Western
   medicine characteristic technology development project [CZXM2022108];
   Jiangsu province key research and development plan special funds
   [BE2018669]
FX Funding This study was supported by grants from Nanjing Drum Tower
   Hospital integrated traditional Chinese and Western medicine
   characteristic technology development project (NO. CZXM2022108) and
   Jiangsu province key research and development plan special funds (No.
   BE2018669) . All authors report no biomedical financial interests.
CR Bach LA, 2015, AM J KIDNEY DIS, V65, P327, DOI 10.1053/j.ajkd.2014.05.024
   Bayat A, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-015-0695-6
   Cao X, 2023, PAIN THER, V12, P1, DOI 10.1007/s40122-022-00451-4
   CARONI P, 1990, J CELL BIOL, V110, P1307, DOI 10.1083/jcb.110.4.1307
   CHAPLAN SR, 1994, J NEUROSCI METH, V53, P55, DOI 10.1016/0165-0270(94)90144-9
   Chen GW, 2022, MINERVA MED, V113, P1051, DOI 10.23736/S0026-4806.20.06843-3
   Chen T, 2022, J Guangzhou Univ Tradit Chin Med., V39, P498
   Cui Y, 2023, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.1056102
   Delaney A, 2009, NEUROTHERAPEUTICS, V6, P630, DOI 10.1016/j.nurt.2009.07.005
   Detloff MR, 2012, JOVE-J VIS EXP, DOI 10.3791/3247
   Devor M, 2018, PAIN REP, V3, DOI 10.1097/PR9.0000000000000702
   Ding XT, 2026, MED GAS RES, V16, P76, DOI 10.4103/mgr.MEDGASRES-D-24-00150
   Dworkin RH, 2010, MAYO CLIN PROC, V85, pS3, DOI 10.4065/mcp.2009.0649
   Fan HR, 2023, PAIN THER, V12, P893, DOI 10.1007/s40122-023-00510-4
   FORNASARI D, 2022, EUR REV MED PHARMACO, V26, P3664, DOI 10.26355/eurrev_202205_28862
   Gao XM, 2023, J TRADIT CHIN MED, V43, P359, DOI 10.19852/j.cnki.jtcm.2023.02.007
   Gilden DH, 2000, NEW ENGL J MED, V342, P635, DOI 10.1056/NEJM200003023420906
   Graeber MB, 2012, EXP NEUROL, V234, P255, DOI 10.1016/j.expneurol.2012.01.007
   Guedon JMG, 2014, GENE THER, V21, P694, DOI 10.1038/gt.2014.43
   Guedon JMG, 2015, VIROLOGY, V482, P167, DOI 10.1016/j.virol.2015.03.046
   HARGREAVES K, 1988, PAIN, V32, P77, DOI 10.1016/0304-3959(88)90026-7
   Hornung R, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21165749
   Hornung R, 2020, NEUROSCI LETT, V736, DOI 10.1016/j.neulet.2020.135287
   Jeong EY, 2013, NEUROSCI LETT, V548, P249, DOI 10.1016/j.neulet.2013.05.038
   Johnson RW, 2014, NEW ENGL J MED, V371, P1526, DOI 10.1056/NEJMcp1403062
   Kong CL, 2020, MOL MED, V26, DOI 10.1186/s10020-020-00232-9
   Li XW, 2016, World J Integr Tradit West Med, V11, P38, DOI [10.13935/j.cnki.sjzx.160111, DOI 10.13935/J.CNKI.SJZX.160111]
   Majava V, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010300
   Miyamoto T, 2005, J CELL BIOL, V169, P527, DOI 10.1083/jcb.200501154
   Reinhold AK, 2019, BBA-MOL BASIS DIS, V1865, P1160, DOI 10.1016/j.bbadis.2019.01.008
   Schmeisser MJ, 2012, J NEUROSCI, V32, P5688, DOI 10.1523/JNEUROSCI.0111-12.2012
   Stein AT, 2006, J GEN PHYSIOL, V128, P509, DOI 10.1085/jgp.200609576
   Stinson C, 2017, BMC NEUROL, V17, DOI 10.1186/s12883-017-0882-6
   Sun R, 2007, NEUROSCIENCE, V144, P286, DOI 10.1016/j.neuroscience.2006.08.084
   Tanabe K, 2021, NEUROSCI LETT, V742, DOI 10.1016/j.neulet.2020.135536
   Tombran-Tink J, 2003, NAT REV NEUROSCI, V4, P628, DOI 10.1038/nrn1176
   [王峰 Wang Feng], 2019, [临床麻醉学杂志, Journal of Clinical Anesthestology], V35, P1209
   Wang G, 2023, ARCH BIOCHEM BIOPHYS, V745, DOI 10.1016/j.abb.2023.109720
   Wang L, 2020, J TRADIT CHIN MED, V40, P121
   Warner BE, 2021, PLOS PATHOG, V17, DOI 10.1371/journal.ppat.1009689
   Westlund KN, 2024, J PAIN, V25, P428, DOI 10.1016/j.jpain.2023.09.015
   Xu JT, 2007, EXP NEUROL, V206, P269, DOI 10.1016/j.expneurol.2007.05.029
   Yu S, 2016, Chin J Pain Med, V22, P161
   Yue JY, 2024, J PAIN RES, V17, P887, DOI 10.2147/JPR.S449211
   Zhang Y, 2024, ARCH DERMATOL RES, V317, DOI 10.1007/s00403-024-03628-3
   Zhu Q, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/9916978
   Zou J, 2019, NEUROTOX RES, V36, P387, DOI 10.1007/s12640-019-00052-8
NR 47
TC 0
Z9 0
U1 8
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7074
J9 INT J GEN MED
JI Int. J. Gen. Med.
PY 2025
VL 18
DI 10.2147/IJGM.S541807
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7PR7V
UT WOS:001576708300001
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, MQ
   Jiang, XB
   Gai, XM
   Dai, MY
   Li, MY
   Wang, YX
   Wang, HF
AF Li, Mengqi
   Jiang, Xiaobo
   Gai, Xiangmu
   Dai, Mengyao
   Li, Mengyuan
   Wang, Yanxin
   Wang, Hongfeng
TI CiteSpace-based visual analysis on transcutaneous electrical acupoint
   stimulation of clinical randomized controlled trial studies and its
   mechanism on perioperative disorders
SO MEDICINE
LA English
DT Article
DE CiteSpace; mechanism; randomized controlled trial; TEAS; visual analysis
ID ELDERLY-PATIENTS; INFLAMMATORY FACTORS; IMMUNOGLOBULIN-A; HUMAN
   OPIORPHIN; PAIN; CELLS; NEUROINFLAMMATION; SUPPRESSION; IMMUNITY;
   DISEASE
AB To systematically present an overview of randomized controlled trials on transcutaneous electrical acupoint stimulation (TEAS) using bibliometric methods, and describe the role and mechanisms of TEAS in most prevalent diseases. Relevant literature was searched in China National Knowledge Infrastructure, Wanfang Data, VIP, SinoMed, PubMed, and Web of Science. The literature was imported and screened into NoteExpress, screened according to inclusion and exclusion criteria, and analyzed using Excel and CiteSpace 6.3R1 software. A total of 1296 documents were included. The number of publications increased annually after 2012. Junlu Wang was the most prolific author. The main research institutions were Peking University, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Shuguang Hospital, and Tongde Hospital of Zhejiang Province. The research hotspots in this field include perioperative care, cancer, pain management, and stroke, primarily focusing on analgesia, immune enhancement, antihypertension, and reduction of gastrointestinal disorders. The main regulatory mechanisms of TEAS include the control of inflammation, oxidative stress, and regulation of the autonomic nervous system. TEAS is most widely used in the elderly, with PC6, ST36, and LI4 being the most frequently studied acupoints in clinical randomized controlled trials. The concept of accelerated rehabilitation is gradually being applied to TEAS, representing an emerging trend for future development. Clinical research on TEAS is rapidly developing, with a focus on applications in cancer and perioperative care. Future research should expand collaboration and conduct high-level clinical and mechanistic studies, which will contribute to the development of standardized protocols and clinical practice.
C1 [Li, Mengqi; Jiang, Xiaobo; Gai, Xiangmu; Dai, Mengyao] Changchun Univ Chinese Med, Coll Acupuncture & Tuina, Changchun, Jilin, Peoples R China.
   [Li, Mengyuan; Wang, Hongfeng] Changchun Univ Chinese Med, Northeast Asia Inst Tradit Chinese Med, Changchun, Jilin, Peoples R China.
   [Wang, Yanxin] Changchun Univ Chinese Med, Clin Affiliated Hosp 3, Dept Cardiovasc Rehabil, Changchun, Jilin, Peoples R China.
C3 Changchun University of Chinese Medicine; Changchun University of
   Chinese Medicine; Changchun University of Chinese Medicine
RP Wang, HF (corresponding author), Changchun Univ Chinese Med, Changchun 130117, Jilin, Peoples R China.
EM lmylixiaoquan@163.com; mengering123@163.com; gxiangmu@163.com;
   22104570702@stu.ccucm.edu.cn; lmylixiaoquan@163.com; ccwhf123@163.com;
   ccwhf@126.com
RI 蒋, 小波/HOA-8635-2023
FU National Key R&D Program of China [2022YFC3500705]
FX This study was supported by grants from the National Key R&D Program of
   China (2022YFC3500705).
CR Adam J, 2023, AUTON NEUROSCI-BASIC, V249, DOI 10.1016/j.autneu.2023.103116
   Altunkaya N, 2018, OBES SURG, V28, P3186, DOI 10.1007/s11695-018-3313-x
   ANGGARD EE, 1990, BLOOD VESSELS, V27, P269
   Ao L, 2021, EXP THER MED, V21, DOI 10.3892/etm.2021.9615
   Argoff C, 2011, CURR MED RES OPIN, V27, P2019, DOI 10.1185/03007995.2011.614934
   Bazoukis G, 2023, J AM HEART ASSOC, V12, DOI 10.1161/JAHA.123.030539
   Bian HT, 2020, J NEUROINFLAMM, V17, DOI 10.1186/s12974-020-01836-y
   Bishir M, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/5764017
   Bradley LM, 1996, J IMMUNOL, V157, P1350
   Bray F, 2024, CA-CANCER J CLIN, V74, P229, DOI 10.3322/caac.21834
   Cai Yuan-Chun, 2024, Zhen Ci Yan Jiu, V49, P283, DOI 10.13702/j.1000-0607.20221402
   Carr DB, 1999, LANCET, V353, P2051, DOI 10.1016/S0140-6736(99)03313-9
   Chen L, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.906528
   Chen X, 2022, PAK J MED SCI, V38, P2118, DOI 10.12669/pjms.38.8.6927
   Chen Y., 2022, Guiding J Tradit Chin Med Pharm, V28, P146
   [中华医学会麻醉学分会穴位刺激围术期应用专家共识工作小组 Chinese Society Of Anesthesiology Task Force On Perioperative Application Of Acupoint Stimulation], 2017, [中华麻醉学杂志, Chinese Journal of Anesthesiology], V37, P1153
   Dai HL, 2013, INJURY, V44, P1521, DOI 10.1016/j.injury.2013.03.015
   Ding LL, 2022, J INTEGR COMPLEMENT, V28, P689, DOI 10.1089/jicm.2021.0141
   Ding Yi, 2023, Zhongguo Zhen Jiu, V43, P282, DOI 10.13703/j.0255-2930.20220419-k0013
   Dockray GJ, 2004, BEST PRACT RES CL EN, V18, P555, DOI 10.1016/j.beem.2004.07.003
   Edvinsson L, 2018, NAT REV NEUROL, V14, P338, DOI 10.1038/s41582-018-0003-1
   Ellyard JI, 2007, TISSUE ANTIGENS, V70, P1, DOI 10.1111/j.1399-0039.2007.00869.x
   Gao Junlong, 2015, Zhongguo Zhen Jiu, V35, P269
   Gong S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117503
   Gu DX, 2017, INT J MED INFORM, V98, P22, DOI 10.1016/j.ijmedinf.2016.11.006
   Han D., 2022, J. Shandong Univ. (Health Sci.), V60, P11
   Hao J, 2015, EUR REV MED PHARMACO, V19, P4642
   Hu SX, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105219
   Huang Jian, 2020, Zhongguo Zhen Jiu, V40, P243, DOI 10.13703/j.0255-2930.20190326-k0010
   Huang KY, 2023, FRONT AGING NEUROSCI, V15, DOI 10.3389/fnagi.2023.1046754
   Irwin MR, 2019, NAT REV IMMUNOL, V19, P702, DOI 10.1038/s41577-019-0190-z
   Jiang Qun, 2019, Zhongguo Zhen Jiu, V39, P1289, DOI 10.13703/j.0255-2930.2019.12.009
   Kempf A, 2019, NATURE, V568, P230, DOI 10.1038/s41586-019-1034-5
   Kirsz K, 2011, PEPTIDES, V32, P2256, DOI 10.1016/j.peptides.2011.04.010
   Kobayashi EH, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11624
   Kolb-Bachofen V, 2006, RHEUMATOLOGY, V45, P17, DOI 10.1093/rheumatology/kel287
   Kong QF, 2009, J NEUROIMMUNOL, V207, P83, DOI 10.1016/j.jneuroim.2008.12.005
   Kong XN, 2010, J IMMUNOL, V185, P569, DOI 10.4049/jimmunol.0902315
   Kostopanagiotou G, 2011, EUR J ANAESTH, V28, P63, DOI 10.1097/EJA.0b013e328340702b
   Kudsk KA, 2008, J TRAUMA, V64, P316, DOI 10.1097/TA.0b013e3181627586
   Lan Y., 2017, J Clin Anesthesiol, V33, P567
   Lan Y, 2021, FRONT MOL BIOSCI, V8, DOI 10.3389/fmolb.2021.681463
   Lancellotti Stefano, 2019, BioMolecular Concepts, V10, P194, DOI [10.1515/bmc-2019-0022, 10.1515/bmc-2019-0022]
   Lang PO, 2012, CLIN INTERV AGING, V7, P55, DOI 10.2147/CIA.S25215
   Lénárt N, 2016, J CEREBR BLOOD F MET, V36, P1668, DOI 10.1177/0271678X16662043
   Leuzy A, 2022, EMBO MOL MED, V14, DOI 10.15252/emmm.202114408
   Li Jian-Li, 2020, Zhen Ci Yan Jiu, V45, P920, DOI 10.13702/j.1000-0607.200060
   Li Jin-Jin, 2016, Zhen Ci Yan Jiu, V41, P240
   Li MM, 2020, NEUROMODULATION, V23, P838, DOI 10.1111/ner.13178
   Li SJ, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000020783
   Li WJ, 2021, J INTEGR MED-JIM, V19, P211, DOI 10.1016/j.joim.2021.01.005
   Liang Han-Sheng, 2017, Zhen Ci Yan Jiu, V42, P522, DOI 10.13702/j.1000-0607.2017.06.011
   Liao W, 2011, CURR OPIN IMMUNOL, V23, P598, DOI 10.1016/j.coi.2011.08.003
   Lin YK, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.978929
   Lin Yufang, 2017, Zhongguo Zhen Jiu, V37, P747, DOI 10.13703/j.0255-2930.2017.07.017
   Liu H, 2013, CHINESE MED J-PEKING, V126, P4444, DOI 10.3760/cma.j.issn.0366-6999.20130654
   Liu TL, 2021, CLIN INTERV AGING, V16, P757, DOI 10.2147/CIA.S309082
   Luscher TF, 1997, CLIN CARDIOL, V20, P3
   Mawe GM, 2013, NAT REV GASTRO HEPAT, V10, P473, DOI 10.1038/nrgastro.2013.105
   Moreira BR, 2019, J ACUPUNCT MERIDIAN, V12, P84
   Nam E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21145007
   Ni P, 2020, NEUROL INDIA, V68, P462, DOI 10.4103/0028-3886.284380
   Peng Li-chao, 2008, Zhongguo Zhen Jiu, V28, P910
   Que B, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5909956
   Ren XF, 2010, ANAESTHESIA, V65, P478, DOI 10.1111/j.1365-2044.2010.06304.x
   Rougeot C, 2010, J PHYSIOL PHARMACOL, V61, P483
   Saravanan B, 2018, INDIAN J ANAESTH, V62, P592, DOI 10.4103/ija.IJA_245_18
   Schreiber RD, 2011, SCIENCE, V331, P1565, DOI 10.1126/science.1203486
   Sul OJ, 2021, MOLECULES, V26, DOI 10.3390/molecules26226949
   Szmit M, 2023, ADV CLIN EXP MED, V32, P1063, DOI 10.17219/acem/159703
   Tian CT, 2015, CHINESE MED J-PEKING, V128, P105, DOI 10.4103/0366-6999.147828
   Tian J, 2020, NEUROCHEM RES, V45, P2926, DOI 10.1007/s11064-020-03141-9
   Tian XZ, 2009, PEPTIDES, V30, P1348, DOI 10.1016/j.peptides.2009.04.002
   Tu Q, 2019, UROLITHIASIS, V47, P279, DOI 10.1007/s00240-018-1056-8
   Waldum H, 2023, FRONT ONCOL, V13, DOI 10.3389/fonc.2023.1176673
   Wang J, 2023, PAIN THER, V12, P707, DOI 10.1007/s40122-023-00493-2
   Wang Ke, 2008, Zhongguo Zhen Jiu, V28, P509
   Wang Kun, 2018, Zhen Ci Yan Jiu, V43, P365, DOI 10.13702/j.1000-0607.170972
   Wang Peng, 2024, Zhongguo Zhen Jiu, V44, P521, DOI 10.13703/j.0255-2930.20231027-k0005
   Wang XB, 2019, J RADIAT RES, V60, P353, DOI 10.1093/jrr/rrz006
   Wang Y., 2015, Chin Acupunct Moxibustion, V35, P1039
   Wei H, 2022, CHIN J INTEGR MED, V28, P730, DOI 10.1007/s11655-022-3516-1
   Wei PL, 2020, COMPUT STRUCT BIOTEC, V18, P843, DOI 10.1016/j.csbj.2020.02.018
   Wittwer A, 2016, PAIN MED, V17, P1131, DOI 10.1093/pm/pnv085
   Woof JM, 2006, J PATHOL, V208, P270, DOI 10.1002/path.1877
   Wu HX, 2016, EXP THER MED, V11, P495, DOI 10.3892/etm.2015.2913
   Wu Yu, 2011, Zhongguo Zhen Jiu, V31, P155
   Xing RY, 2022, PAIN THER, V11, P1327, DOI 10.1007/s40122-022-00429-2
   Yang X, 2015, INT J CLIN EXP MED, V8, P15630
   Yousuf O, 2013, J AM COLL CARDIOL, V62, P397, DOI 10.1016/j.jacc.2013.05.016
   Yu Jian-ming, 2010, Zhen Ci Yan Jiu, V35, P43
   Zeng A, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2207436119
   Zhang B, 2018, AM J GASTROENTEROL, V113, P1026, DOI 10.1038/s41395-018-0156-y
   Zhang RY, 2020, ARQ NEURO-PSIQUIAT, V78, P617, DOI [10.1590/0004-282X20200078, 10.1590/0004-282x20200078]
   Zhang W, 2021, NEURAL REGEN RES, V16, P6, DOI 10.4103/1673-5374.286954
   Zhang YF, 2022, CLIN INTERV AGING, V17, P1751, DOI 10.2147/CIA.S382912
   Zhao Fang-Chao, 2021, Zhen Ci Yan Jiu, V46, P684, DOI [10.13702/j.1000-0607.200784, 10.13702/j.1000-0607.200784]
   Zheng T, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2024.e26173
   [周慕姣 Zhou Mujiao], 2023, [中国循证医学杂志, Chinese Journal of Evidence-Based Medicine], V23, P1393
   Zhou WC, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.00179
   Zhu K, 2020, BMC MUSCULOSKEL DIS, V21, DOI 10.1186/s12891-020-3070-6
   Zhu Y, 2020, NEUROMODULATION, V23, P1180, DOI 10.1111/ner.13158
NR 102
TC 2
Z9 2
U1 5
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 11
PY 2024
VL 103
IS 41
AR e39893
DI 10.1097/MD.0000000000039893
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA J7B7K
UT WOS:001338585900098
PM 39465871
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU D'Souza, RS
   Alvarez, GAM
   Dombovy-Johnson, M
   Eller, J
   Abd-Elsayed, A
AF D'Souza, Ryan S.
   Alvarez, Gabriel A. Martinez
   Dombovy-Johnson, Marissa
   Eller, Jennifer
   Abd-Elsayed, Alaa
TI Evidence-Based Treatment of Pain in Chemotherapy-Induced Peripheral
   Neuropathy
SO CURRENT PAIN AND HEADACHE REPORTS
LA English
DT Review
DE Peripheral neuropathy; Chemotherapy; Cancer; Chronic pain; Systematic
   review; Neuromodulation
ID ADVANCED CANCER-PATIENTS; DOUBLE-BLIND; SCRAMBLER THERAPY; ADJUNCTIVE
   THERAPY; NERVE-STIMULATION; AMERICAN SOCIETY; OROMUCOSAL SPRAY; PILOT
   TRIAL; ACUPUNCTURE; NEUROTOXICITY
AB Purpose of ReviewChemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and often painful condition that occurs after administration of chemotherapeutic agents. The primary objective of this systematic review was to appraise the literature on conservative, pharmacological, and interventional treatment options for CIPN pain.Recent FindingsThere is level I evidence supporting modest to moderate improvement in CIPN pain from duloxetine treatment, as well as short-term modest improvement from physical therapy and acupuncture. Although opioid and cannabis administration may provide short-term modest improvement, administration is commonly limited by side effects. Generally, most studies reported no clinical benefit from yoga, topical neuropathic agents, gabapentinoids, and tricyclic antidepressants. Evidence is currently equivocal for scrambler therapy and transcutaneous electrical nerve stimulation. Finally, evidence on neuromodulation options is limited to mostly case reports/series and one observational study highlighting moderate improvement with auricular nerve stimulation.This systematic review provides an overview of conservative, pharmacologic, and interventional treatment modalities for CIPN pain. Furthermore, it provides a level of evidence and degree of recommendation based on the United States Preventive Services Task Force (USPSTF) criteria for each specific treatment modality.
C1 [D'Souza, Ryan S.; Eller, Jennifer] Mayo Clin Hosp, Dept Anesthesiol & Perioperat Med, Rochester, MN USA.
   [Alvarez, Gabriel A. Martinez; Dombovy-Johnson, Marissa] Mayo Clin Hosp, Dept Phys Med & Rehabil, Rochester, MN USA.
   [Abd-Elsayed, Alaa] Univ Wisconsin, Dept Anesthesiol, Madison, WI 53715 USA.
C3 Mayo Clinic; Mayo Clinic; University of Wisconsin System; University of
   Wisconsin Madison
RP Abd-Elsayed, A (corresponding author), Univ Wisconsin, Dept Anesthesiol, Madison, WI 53715 USA.
EM abdelsayed@wisc.edu
OI D'Souza, Ryan/0000-0002-4601-9837
CR Anand P, 2019, J PAIN RES, V12, P2039, DOI 10.2147/JPR.S213912
   Argyriou AA, 2012, CRIT REV ONCOL HEMAT, V82, P51, DOI 10.1016/j.critrevonc.2011.04.012
   Avan R, 2018, J RES MED SCI, V23, DOI 10.4103/jrms.JRMS_1068_17
   Bao T, 2020, JNCI CANCER SPECT, V4, DOI 10.1093/jncics/pkaa048
   Bao T, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.0681
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Barton DL, 2011, SUPPORT CARE CANCER, V19, P833, DOI 10.1007/s00520-010-0911-0
   Ben-Arye E, 2022, CANCER-AM CANCER SOC, V128, P3641, DOI 10.1002/cncr.34422
   Ben-Horin I, 2017, INTEGR CANCER THER, V16, P258, DOI 10.1177/1534735417690254
   Burgess J, 2021, ONCOL THER, V9, P385, DOI 10.1007/s40487-021-00168-y
   Cartoni C, 2012, SUPPORT CARE CANCER, V20, P2621, DOI 10.1007/s00520-012-1511-y
   Chen HP, 2014, NEUROCHEM RES, V39, P76, DOI 10.1007/s11064-013-1192-z
   Chien A, 2021, PM&R, V13, P55, DOI 10.1002/pmrj.12361
   Childs DS, 2021, J PAIN SYMPTOM MANAG, V61, P1247, DOI 10.1016/j.jpainsymman.2020.11.025
   Cioroiu C, 2017, CURR NEUROL NEUROSCI, V17, DOI 10.1007/s11910-017-0757-7
   Clark PG, 2012, J EVID-BASED INTEGR, V17, P161, DOI 10.1177/2156587212450175
   Coyne Patrick J, 2013, J Pain Palliat Care Pharmacother, V27, P359, DOI 10.3109/15360288.2013.847519
   D'Alessandro EG, 2022, BMJ SUPPORT PALLIAT, V12, P64, DOI 10.1136/bmjspcare-2018-001542
   D'Souza RS, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10081909
   de Moor JS, 2013, CANCER EPIDEM BIOMAR, V22, P561, DOI 10.1158/1055-9965.EPI-12-1356
   Dhawan S, 2020, CANCER NURS, V43, P269, DOI 10.1097/NCC.0000000000000693
   Fallon MT, 2017, BRIT J PAIN, V11, P119, DOI 10.1177/2049463717710042
   Farshchian N, 2018, CANCER CHEMOTH PHARM, V82, P787, DOI 10.1007/s00280-018-3664-y
   Fernandes J, 2016, INT J REHABIL RES, V39, P368, DOI 10.1097/MRR.0000000000000196
   Filipczak-Bryniarska I, 2017, MED ONCOL, V34, DOI 10.1007/s12032-017-1015-1
   Friedemann T, 2022, PHYTOMEDICINE, V104, DOI 10.1016/j.phymed.2022.154294
   Galantino Mary Lou, 2020, Int J Yoga Therap, V30, P49, DOI [10.17761/2020-d-18-00030, 10.17761/2020-D-18-00030]
   Galantino ML, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419850627
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Gewandter JS, 2019, SUPPORT CARE CANCER, V27, P1765, DOI 10.1007/s00520-018-4424-6
   Gewandter JS, 2014, SUPPORT CARE CANCER, V22, P1807, DOI 10.1007/s00520-014-2158-7
   Hagedorn JM, 2020, J PAIN RES, V13, P3295, DOI 10.2147/JPR.S263857
   Hammack JE, 2002, PAIN, V98, P195, DOI 10.1016/S0304-3959(02)00047-7
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Hershman DL, 2011, BREAST CANCER RES TR, V125, P767, DOI 10.1007/s10549-010-1278-0
   Hill KP, 2017, POL ARCH INTERN MED, V127, P785, DOI 10.20452/pamw.4123
   Hincker A, 2019, PAIN, V160, P1835, DOI 10.1097/j.pain.0000000000001577
   Hsieh YL, 2016, ACUPUNCT MED, V34, P398, DOI 10.1136/acupmed-2016-011112
   Huang CC, 2021, J CLIN MED, V10, DOI 10.3390/jcm10163694
   Iravani S, 2020, PAIN RES MANAG, V2020, DOI 10.1155/2020/2504674
   Jeong YJ, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/5367014
   Kautio AL, 2008, J PAIN SYMPTOM MANAG, V35, P31, DOI 10.1016/j.jpainsymman.2007.02.043
   Kautio AL, 2009, ANTICANCER RES, V29, P2601
   Kneis S, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-5522-7
   Knoerl R, 2022, J CANCER SURVIV, V16, P882, DOI 10.1007/s11764-021-01081-z
   Lichtman AH, 2018, J PAIN SYMPTOM MANAG, V55, P179, DOI 10.1016/j.jpainsymman.2017.09.001
   Loprinzi C, 2020, SUPPORT CARE CANCER, V28, P1183, DOI 10.1007/s00520-019-04881-3
   Loprinzi CL, 2020, J CLIN ONCOL, V38, DOI 10.1200/JCO.20.01399
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Lynch ME, 2014, J PAIN SYMPTOM MANAG, V47, P166, DOI 10.1016/j.jpainsymman.2013.02.018
   Magnowska M, 2018, GINEKOL POL, V89, P200, DOI 10.5603/GP.a2018.0034
   Matsuoka H, 2019, J PAIN SYMPTOM MANAG, V58, P645, DOI 10.1016/j.jpainsymman.2019.06.020
   McCrary JM, 2019, SUPPORT CARE CANCER, V27, P3849, DOI 10.1007/s00520-019-04680-w
   Miaskowski C, 2017, J PAIN SYMPTOM MANAG, V54, P204, DOI 10.1016/j.jpainsymman.2016.12.342
   Nagashima M, 2014, SUPPORT CARE CANCER, V22, P1579, DOI 10.1007/s00520-014-2132-4
   Otake A, 2015, ANTICANCER RES, V35, P359
   Pachman DR, 2015, SUPPORT CARE CANCER, V23, P943, DOI 10.1007/s00520-014-2424-8
   Park SB, 2013, CA-CANCER J CLIN, V63, P419, DOI 10.3322/caac.21204
   Pike Crystal T, 2012, Chemother Res Pract, V2012, P913848, DOI 10.1155/2012/913848
   Portenoy RK, 2012, J PAIN, V13, P438, DOI 10.1016/j.jpain.2012.01.003
   Rao RD, 2007, CANCER-AM CANCER SOC, V110, P2110, DOI 10.1002/cncr.23008
   Rostock M, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/349653
   Sacco J, 2016, MED ACUPUNCT, V28, P131, DOI 10.1089/acu.2016.1170
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Schwenk M, 2016, GERONTOLOGY, V62, P553, DOI 10.1159/000442253
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Smith TJ, 2020, J PALLIAT CARE, V35, P53, DOI 10.1177/0825859719827589
   Smith TJ, 2010, J PAIN SYMPTOM MANAG, V40, P883, DOI 10.1016/j.jpainsymman.2010.03.022
   Strand N, 2022, J PAIN RES, V15, P2483, DOI 10.2147/JPR.S362204
   Streckmann F, 2019, SUPPORT CARE CANCER, V27, P2471, DOI 10.1007/s00520-018-4531-4
   Stringer J, 2022, EUR J ONCOL NURS, V60, DOI 10.1016/j.ejon.2022.102171
   Tonello R, 2019, J PAIN, V20, P515, DOI 10.1016/j.jpain.2018.11.003
   Tonezzer Tania, 2017, J Phys Ther Sci, V29, P685, DOI [10.1589/jpts.29.685, 10.1589/jpts.29.685]
   Tsavaris N, 2008, PAIN MED, V9, P1209, DOI 10.1111/j.1526-4637.2007.00325.x
   Velasco R, 2021, ANTI-CANCER DRUG, V32, P88, DOI 10.1097/CAD.0000000000001005
   Waissengrin B, 2021, THER ADV MED ONCOL, V13, DOI 10.1177/1758835921990203
   Whiting PF, 2015, JAMA-J AM MED ASSOC, V313, P2456, DOI 10.1001/jama.2015.6358
   Wonders KY, 2013, HEALTH PSYCHOL RES, V1, P149, DOI [10.4082/hpr.2013.e28, 10.4081/hpr.2013.e28]
   Wong R, 2016, INTEGR CANCER THER, V15, P153, DOI 10.1177/1534735415627926
   Yang YH, 2012, SUPPORT CARE CANCER, V20, P1491, DOI 10.1007/s00520-011-1237-2
   Zajaczkowska R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061451
   Zhang SQ, 2017, J TRADIT CHIN MED, V37, P179
NR 84
TC 32
Z9 34
U1 5
U2 22
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1531-3433
EI 1534-3081
J9 CURR PAIN HEADACHE R
JI Curr. Pain Headache Rep.
PD MAY
PY 2023
VL 27
IS 5
BP 99
EP 116
DI 10.1007/s11916-023-01107-4
EA APR 2023
PG 18
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AK8R1
UT WOS:000968770900001
PM 37058254
DA 2026-01-16
ER

PT J
AU Kim, W
   Kim, MJ
   Go, D
   Min, BI
   Na, HS
   Kim, SK
AF Kim, Woojin
   Kim, Min Joon
   Go, Donghyun
   Min, Byung-Il
   Na, Heung Sik
   Kim, Sun Kwang
TI Combined Effects of Bee Venom Acupuncture and Morphine on
   Oxaliplatin-Induced Neuropathic Pain in Mice
SO TOXINS
LA English
DT Article
DE bee venom acupuncture; chemotherapy induced neuropathic pain; morphine;
   oxaliplatin
ID INDUCED PERIPHERAL NEUROPATHY; ACUPOINT STIMULATION; FORMALIN TEST;
   OPIOID RESPONSIVENESS; RAT MODEL; APIPUNCTURE; MANAGEMENT; BEHAVIOR;
   ANTINOCICEPTION; INVOLVEMENT
AB Oxaliplatin, a chemotherapeutic drug for colorectal cancer, induces severe peripheral neuropathy. Bee venom acupuncture (BVA) has been used to attenuate pain, and its effect is known to be mediated by spinal noradrenergic and serotonergic receptors. Morphine is a well-known opioid used to treat different types of pain. Here, we investigated whether treatment with a combination of these two agents has an additive effect on oxaliplatin-induced neuropathic pain in mice. To assess cold and mechanical allodynia, acetone and von Frey filament tests were used, respectively. Significant allodynia signs were observed three days after an oxaliplatin injection (6 mg/kg, i.p.). BVA (0.25, 1, and 2.5 mg/kg, s.c., ST36) or morphine (0.5, 2, and 5 mg/kg, i.p.) alone showed dose-dependent anti-allodynic effects. The combination of BVA and morphine at intermediate doses showed a greater and longer effect than either BVA or morphine alone at the highest dose. Intrathecal pretreatment with the opioidergic (naloxone, 20 g) or 5-HT3 (MDL-72222, 15 g) receptor antagonist, but not with (2)-adrenergic (idazoxan, 10 g) receptor antagonist, blocked this additive effect. Therefore, we suggest that the combination effect of BVA and morphine is mediated by spinal opioidergic and 5-HT3 receptors and this combination has a robust and enduring analgesic action against oxaliplatin-induced neuropathic pain.
C1 [Kim, Woojin; Kim, Sun Kwang] Kyung Hee Univ, Dept Physiol, Coll Korean Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Kim, Woojin; Kim, Min Joon; Go, Donghyun; Kim, Sun Kwang] Kyung Hee Univ, Grad Sch, Dept East West Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Min, Byung-Il] Yeongju Municipal Hosp, 697 Jangan Ro, Gyeongsangbuk Do 36051, Yeongju Si, South Korea.
   [Na, Heung Sik] Korea Univ, Dept Physiol, Coll Med, Seoul 02842, South Korea.
C3 Kyung Hee University; Kyung Hee University; Korea University; Korea
   University Medicine (KU Medicine)
RP Kim, SK (corresponding author), Kyung Hee Univ, Dept Physiol, Coll Korean Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.; Kim, SK (corresponding author), Kyung Hee Univ, Grad Sch, Dept East West Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.
EM thasnow@gmail.com; junesnest@naver.com; drum2r@daum.net; mbi@khu.ac.kr;
   hsna@korea.ac.kr; skkim77@khu.ac.kr
RI MIN, B. I./U-3364-2017; Kim, Woojin/AAK-2464-2020; Kim, Sun
   Kwang/AAM-1289-2020
OI Kim, Woojin/0000-0001-8494-4524; Kim, Sun Kwang/0000-0002-2649-6652
FU National Research Foundation of Korea (NRF) Grant - Korean Government
   [NRF-2013R1A1A1012403]
FX This work was supported by a grant from the National Research Foundation
   of Korea (NRF) Grant funded by the Korean Government
   (NRF-2013R1A1A1012403).
CR Arany I, 2003, SEMIN NEPHROL, V23, P460, DOI 10.1016/S0270-9295(03)00089-5
   Argyriou AA, 2008, CANCER TREAT REV, V34, P368, DOI 10.1016/j.ctrv.2008.01.003
   ARNER S, 1985, ACTA ANAESTH SCAND, V29, P32, DOI 10.1111/j.1399-6576.1985.tb02155.x
   Baek YH, 2006, BRAIN RES, V1073, P305, DOI 10.1016/j.brainres.2005.12.086
   CHERNY NI, 1994, NEUROLOGY, V44, P857, DOI 10.1212/WNL.44.5.857
   Cho SY, 2012, PARKINSONISM RELAT D, V18, P948, DOI 10.1016/j.parkreldis.2012.04.030
   Ferlay J, 2015, INT J CANCER, V136, pE359, DOI [10.14343/jcscr.2016.4e1003, 10.1002/ijc.29210]
   Flatters SJL, 2004, PAIN, V109, P150, DOI 10.1016/j.pain.2004.01.029
   Fukushima T, 2011, BMC NEUROSCI, V12, DOI 10.1186/1471-2202-12-36
   Gamelin E, 2002, SEMIN ONCOL, V29, P21, DOI 10.1053/sonc.2002.35525
   Gilron I, 2005, NEW ENGL J MED, V352, P1324, DOI 10.1056/NEJMoa042580
   GIORDANO J, 1991, EUR J PHARMACOL, V199, P233, DOI 10.1016/0014-2999(91)90462-Y
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   Han Yook Tae, 2000, Journal of Pharmacopuncture, V3, P119, DOI 10.3858/KPI.3.1.119
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Joseph EK, 2009, J PAIN, V10, P534, DOI 10.1016/j.jpain.2008.12.003
   Kang SY, 2015, TOXINS, V7, P2571, DOI 10.3390/toxins7072571
   Kim C., 2001, J KOR AM MERIDIAN PO, V18, P141, DOI DOI 10.1093/ECAM/NEH070
   Kim HW, 2005, PHARMACOL RES, V51, P183, DOI 10.1016/j.phrs.2004.07.011
   Kim HW, 2003, J VET MED SCI, V65, P349, DOI 10.1292/jvms.65.349
   Kim W, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/436913
   Kwon YB, 2005, PHARMACOL BIOCHEM BE, V80, P181, DOI 10.1016/j.pbb.2004.10.017
   Kwon YB, 2001, NEUROSCI LETT, V308, P133, DOI 10.1016/S0304-3940(01)01989-9
   Kwon YB, 2006, NEUROSCI RES, V55, P197, DOI 10.1016/j.neures.2006.03.003
   Lee JD, 2005, EVID-BASED COMPL ALT, V2, P79, DOI 10.1093/ecam/neh070
   Lee JH, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-471
   Lee MS, 2008, J PAIN, V9, P289, DOI 10.1016/j.jpain.2007.11.012
   LEE YW, 1995, NEUROSCI LETT, V199, P111, DOI 10.1016/0304-3940(95)12034-2
   Lehky RJ, 2004, MUSCLE NERVE, V29, P387, DOI 10.1002/mus.10559
   Lemberg K, 2006, ANESTH ANALG, V102, P1768, DOI 10.1213/01.ane.0000205751.88422.41
   Li D, 2015, TOXINS, V7, P2422, DOI 10.3390/toxins7072422
   Lim B. -S., 2013, ALTERN MED, V2013, DOI [10.1155/2013/36932424058370, DOI 10.1155/2013/36932424058370]
   Ling B, 2008, NEUROPHARMACOLOGY, V55, P724, DOI 10.1016/j.neuropharm.2008.06.007
   Ling B, 2007, TOXICOLOGY, V234, P176, DOI 10.1016/j.tox.2007.02.013
   Moon HJ, 2014, J PHYSIOL SCI, V64, P151, DOI 10.1007/s12576-013-0297-0
   Omiya Y, 2005, J PHARMACOL SCI, V99, P373, DOI 10.1254/jphs.FP0050536
   Ormseth MJ, 2011, PATIENT PREFER ADHER, V5, P343, DOI 10.2147/PPA.S16358
   Pasetto LM, 2006, CRIT REV ONCOL HEMAT, V59, P159, DOI 10.1016/j.critrevonc.2006.01.001
   PORTENOY RK, 1990, PAIN, V43, P273, DOI 10.1016/0304-3959(90)90025-9
   Roh DH, 2006, J PAIN, V7, P500, DOI 10.1016/j.jpain.2006.02.002
   Roh DH, 2004, J PAIN, V5, P297, DOI 10.1016/j.jpain.2004.05.003
   Screnci D, 2000, BRIT J CANCER, V82, P966, DOI 10.1054/bjoc.1999.1026
   Serpell MG, 2002, PAIN, V99, P557, DOI 10.1016/S0304-3959(02)00255-5
   Shibata K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023510
   Son DJ, 2007, PHARMACOL THERAPEUT, V115, P246, DOI 10.1016/j.pharmthera.2007.04.004
   Tsuchiya M, 1999, NEUROREPORT, V10, P2749, DOI 10.1097/00001756-199909090-00010
   Wolf S, 2008, EUR J CANCER, V44, P1507, DOI 10.1016/j.ejca.2008.04.018
   YAKSH TL, 1979, BRAIN RES, V171, P176, DOI 10.1016/0006-8993(79)90747-9
   YANG SW, 1994, BRAIN RES BULL, V35, P113
   Yekkirala AS, 2010, ACS CHEM NEUROSCI, V1, P146, DOI 10.1021/cn9000236
   Yoon J, 2012, J ACUPUNCT MERIDIAN, V5, P156, DOI [10.1016/j.jams.2012.05.003, 10.106/j.jams.2012.05.003]
   Yoon SY, 2009, J PAIN, V10, P253, DOI 10.1016/j.jpain.2008.09.002
NR 52
TC 49
Z9 52
U1 1
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6651
J9 TOXINS
JI Toxins
PD FEB
PY 2016
VL 8
IS 2
AR 33
DI 10.3390/toxins8020033
PG 11
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA DG1MC
UT WOS:000371831200012
PM 26805884
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yu, NN
   Yang, FM
   Zhao, X
   Guo, YM
   Xu, Y
   Pang, GC
   Gong, YN
   Wang, SJ
   Liu, YY
   Fang, YX
   Yu, K
   Yao, L
   Wang, H
   Zhang, K
   Liu, BH
   Wang, ZG
   Guo, Y
   Xu, ZF
AF Yu, Nannan
   Yang, Fuming
   Zhao, Xue
   Guo, Yongming
   Xu, Yuan
   Pang, Guangchang
   Gong, Yinan
   Wang, Shenjun
   Liu, Yangyang
   Fang, Yuxin
   Yu, Kun
   Yao, Lin
   Wang, Hui
   Zhang, Kuo
   Liu, Baohu
   Wang, Zhenguo
   Guo, Yi
   Xu, Zhifang
TI Manual acupuncture at ST36 attenuates rheumatoid arthritis by inhibiting
   M1 macrophage polarization and enhancing Treg cell populations in
   adjuvant-induced arthritic rats
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE adjuvant-induced arthritis; macrophage polarization; manual acupuncture;
   regulatory T cells; transforming growth factor beta 1
ID REGULATORY T-CELLS; PATHOGENESIS; INFLAMMATION; MODULATION; CYTOKINES;
   PATHWAYS; TH17
AB Objectives: Acupuncture has been found to be effective at relieving many inflammatory pain conditions, including rheumatoid arthritis (RA). We aimed to assess the anti-inflammatory potential of manual acupuncture (MA) treatment of RA using adjuvant-induced arthritic (AIA) rats and to explore the underlying mechanisms.
   Methods: The anti-inflammatory and analgesic actions of MA at ST36 (Zusanli) in AIA rats were assessed using paw withdrawal latency and swelling, histological examination and cytokine detection by enzyme-linked immunoassay (ELISA). The cell-cell communication (CCC) network was analyzed with a multiplex immunoassay of 24 immune factors expressed in the inflamed joints, and the macrophage and Treg populations and associated cytokines regulated by MA were investigated using reverse-transcription quantitative polymerase chain reaction (RT-qPCR), ELISA and flow cytometry.
   Results: MA markedly decreased heat hyperalgesia and paw swelling in AIA rats. MA-treated rats also exhibited decreased levels of pro-inflammatory cytokines (tumor necrosis factor (TNF)-alpha, interleukin (1L)-1 beta) coupled with increased anti-inflammatory cytokines (1L-10, transforming growth factor (TGF)-beta 1) in the ankle joints at protein and mRNA levels. CCC network analysis confirmed that macrophages are of critical importance and are potential therapeutic targets in RA. Repeated treatment with MA triggered a macrophage phenotypic switch in the paws, with fewer M1 macrophages. Prominent increases in the Treg cell population and TGF-beta 1 in the popliteal lymph nodes demonstrated the immunomodulatory effects of MA. Furthermore, a selective TGF-beta 1-receptor inhibitor, SB431542, attenuated the anti-inflammatory effects of MA and MA-induced suppression of the levels of M1-released cytokines.
   Conclusion: These findings provide novel evidence that the anti-inflammatory and analgesic effects of MA on RA act through phenotypic modulation involving the inhibition of M1 macrophage polarization and an increase in the Treg cell population, highlighting the potential therapeutic advantages of acupuncture in controlling pain and ameliorating inflammatory conditions.
C1 [Yu, Nannan; Yang, Fuming; Zhao, Xue; Guo, Yongming; Xu, Yuan; Gong, Yinan; Wang, Shenjun; Liu, Yangyang; Fang, Yuxin; Yu, Kun; Yao, Lin; Wang, Hui; Zhang, Kuo; Guo, Yi; Xu, Zhifang] Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, Tianjin, Peoples R China.
   [Yu, Nannan] Air Force Med Univ, Affiliated Hosp 1, Dept Tradit Chinese Med, Xian, Peoples R China.
   [Zhao, Xue; Guo, Yongming; Xu, Yuan; Wang, Shenjun; Liu, Yangyang; Fang, Yuxin; Guo, Yi; Xu, Zhifang] Natl Clin Res Ctr Chinese Med Acupuncture & Moxib, Tianjin, Peoples R China.
   [Zhao, Xue; Guo, Yongming; Xu, Yuan; Wang, Shenjun; Liu, Yangyang; Fang, Yuxin; Xu, Zhifang] Tianjin Univ Tradit Chinese Med, Sch Acupuncture & Moxibust & Tuina, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.
   [Pang, Guangchang] Tianjin Univ Commerce, Coll Biotechnol & Food Sci, Tianjin Key Lab Food Biotechnol, Tianjin, Peoples R China.
   [Liu, Baohu] China Acad Chinese Med Sci, Dept Rehabil, Wangjing Hosp, Beijing, Peoples R China.
   [Wang, Zhenguo] Xian Encephalopathy Hosp Tradit Chinese Med, Xian, Peoples R China.
   [Guo, Yi] Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Air Force Medical
   University; Tianjin University of Traditional Chinese Medicine; Tianjin
   University of Commerce; Wang Jing Hospital, CACMS; China Academy of
   Chinese Medical Sciences; Tianjin University of Traditional Chinese
   Medicine
RP Xu, ZF (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Acupuncture & Moxibust & Tuina, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.; Guo, Y (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.
EM guoyi_168@163.com; xuzhifangmsn@hotmail.com
RI Xu, Zhifang/AAF-4798-2019; guo, yi/KHC-4669-2024
OI Xu, Zhifang/0000-0002-0576-163X; 
FU National Natural Science Foundation of China (NSFC) [81873369, 81904281,
   81330088, 81704146]; Shaanxi Administration of Traditional Chinese
   Medicine [2019-ZZ-JC013]
FX The authors disclosed receipt of the following financial support for the
   research, authorship and/or publication of this article: This work was
   financially supported by the National Natural Science Foundation of
   China (NSFC; grant no. 81873369, 81904281, 81330088 and 81704146) and
   Shaanxi Administration of Traditional Chinese Medicine (grant no.
   2019-ZZ-JC013).
CR Astry B, 2011, J INTERF CYTOK RES, V31, P927, DOI 10.1089/jir.2011.0094
   Chen J, 2013, CELL PHYSIOL BIOCHEM, V32, P1265, DOI 10.1159/000354525
   Choudhary N, 2018, IMMUNOPHARM IMMUNOT, V40, P193, DOI 10.1080/08923973.2018.1434793
   Choy EHS, 2001, NEW ENGL J MED, V344, P907, DOI 10.1056/NEJM200103223441207
   Croia C, 2019, CLIN EXP RHEUMATOL, V37, P347
   Dey I, 2020, EXP MOL PATHOL, V116, DOI 10.1016/j.yexmp.2020.104485
   Dougados M, 2014, ANN RHEUM DIS, V73, P62, DOI 10.1136/annrheumdis-2013-204223
   Firestein GS, 2003, NATURE, V423, P356, DOI 10.1038/nature01661
   Jovanovic DV, 1998, J IMMUNOL, V160, P3513
   Kryczek I, 2007, CANCER RES, V67, P8900, DOI 10.1158/0008-5472.CAN-07-1866
   Liu GW, 2011, IMMUNOL CELL BIOL, V89, P130, DOI 10.1038/icb.2010.70
   Municio C, 2018, ANN RHEUM DIS, V77, P752, DOI 10.1136/annrheumdis-2017-212537
   Roberts CA, 2015, FRONT IMMUNOL, V6, P1, DOI 10.3389/fimmu.2015.00571
   Scott David L, 2010, Lancet, V376, P1094, DOI 10.1016/S0140-6736(10)60826-4
   Sultana F, 2017, COLLOID SURFACE B, V155, P349, DOI 10.1016/j.colsurfb.2017.04.046
   Taams LS, 2005, HUM IMMUNOL, V66, P222, DOI 10.1016/j.humimm.2004.12.006
   Tam Lai-Shan, 2007, BMC Complement Altern Med, V7, P35, DOI 10.1186/1472-6882-7-35
   Tiemessen MM, 2007, P NATL ACAD SCI USA, V104, P19446, DOI 10.1073/pnas.0706832104
   Toh ML, 2007, CURR OPIN RHEUMATOL, V19, P284, DOI 10.1097/BOR.0b013e32805e87e0
   Torres-Rosas R, 2014, NAT MED, V20, P291, DOI 10.1038/nm.3479
   Udalova IA, 2016, NAT REV RHEUMATOL, V12, P472, DOI 10.1038/nrrheum.2016.91
   World Health Organization, 2002, Acupuncture: review and analysis of reports on controlled clinical trials
   Wynn TA, 2013, NATURE, V496, P445, DOI 10.1038/nature12034
   Xu Y, 2018, AM J CHINESE MED, V46, P997, DOI 10.1142/S0192415X18500520
   Yuan XS, 2016, BIOCHEM PHARMACOL, V101, P87, DOI 10.1016/j.bcp.2015.11.025
   ZHANG K, 2018, EVID-BASED COMPL ALT, V2018, DOI DOI 10.1155/2018/9260630
NR 26
TC 14
Z9 18
U1 4
U2 50
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD APR
PY 2023
VL 41
IS 2
BP 96
EP 109
DI 10.1177/09645284221085278
EA MAY 2022
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA E4PH3
UT WOS:000799715200001
PM 35585798
DA 2026-01-16
ER

PT J
AU Wu, HY
   Liu, Y
   Chen, YZ
   Xie, YZ
   Zhong, L
   Yu, Y
   Fan, XH
AF Wu, Haoyang
   Liu, Yuan
   Chen, Yuzhou
   Xie, Yizhou
   Zhong, Lei
   Yu, Yang
   Fan, Xiaohong
TI Effect of pestle needle therapy on the posterior cervical muscle in a
   rabbit model of cervical spondylosis
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE spondylosis; pestle needle; phosphatidylinositol 3-kinase;
   proto-oncogene proteins c-akt; TOR serine-threonine kinases; apoptosis;
   autophagy
ID PAIN; ACUPUNCTURE; STIMULATION; DEGRADATION
AB OBJECTIVE: To investigate the effect of pestle needle therapy (PNT) on the posterior cervical muscle (PCM) in a rabbit model of cervical spondylosis (CS) and explore the underlying mechanisms. METHODS: Rabbits were divided into control, CS models I and II (CS1 and CS2), electroacupuncture (EA), PNT I and II (PN1 and PN2), activator (AVT), and PNT combined with activator (C-AVT) groups. A long-term neck immobilization technique was used to establish a rabbit model of CS. Following completion of modeling, the EA group received electroacupuncture intervention, whereas the CS1, CS2, and C-AVT groups received PNT intervention. The AVT and C-AVT groups received local 740 Y-P injections into the PCM daily. The inflammatory injury to PCM was evaluated based on pain threshold, morphological changes, and interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha levels. PCM fibrosis was evaluated by measuring the positive area (PA) of collagen fibrils (CFs) and collagen type 1 alpha 1 (Col1 alpha 1) using Masson's and immunohistochemical staining. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay and transmission electron microscopy were used to identify apoptotic cells and assess autophagy, respectively. Western blotting was used to determine B-cell lymphoma-2 (Bcl-2), Bcl-2 associated X protein (Bax), cysteine aspartate-specific protease (caspase)-3, sequestosome-1 (P62), microtubuleassociated protein light chain 3 (LC3-I/II), phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and mammalian target of rapamycin (mTOR) levels. Real-time quantitative polymerase chain reaction was used to determine mRNA expression levels of PI3K, AKT, mTOR, autophagy protein (ATG), and ATG7. RESULTS: PNT alleviated PCM cell degeneration and necrosis, inhibited inflammatory cell infiltration, decreased IL-1 beta, IL-6, and TNF-alpha levels, and decreased the PA of CFs and Col1 alpha 1. In the PN1 group, cell apoptosis in the PCM decreased, autophagy increased, Bcl-2 and LC3-II/I levels increased, Bax, Caspase-3, and P62 levels decreased, and the mRNA expression of ATG5 and ATG7 increased. PNT inhibits protein and mRNA expression of PI3K, AKT, and mTOR. Finally, the trend in the results of the rescue experiment was consistent with previous results. CONCLUSION: PNT inhibited apoptosis and promoted autophagy of PCM cells in CS rabbits and alleviated inflammation and fibrosis injury of PCM by inhibiting the PI3K/AKT/mTOR pathway.
C1 [Wu, Haoyang; Liu, Yuan; Chen, Yuzhou; Xie, Yizhou] Chengdu Univ Tradit Chinese Med, Coll Clin Med, Chengdu 610032, Peoples R China.
   [Zhong, Lei; Yu, Yang; Fan, Xiaohong] Chengdu Univ Tradit Chinese Med, Affiliated Hosp, Dept Orthopaed, Chengdu 610075, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Yu, Y; Fan, XH (corresponding author), Chengdu Univ Tradit Chinese Med, Affiliated Hosp, Dept Orthopaed, Chengdu 610075, Peoples R China.
EM spine_yy@163.com; fxh202010@2980.com
RI Fan, Xiaohong/AEC-5385-2022; chen, yuzhou/OAL-1414-2025
FU Sichuan Provincial Administration of Traditional Chinese Medicine Key
   Project of Scientific Research in Traditional Chinese Medicine
   [2023zd025]; Scientific Research Project of Sichuan Provincial Science
   and Technology Department: Improvement of cartilage Degeneration in Knee
   Osteoarthritis by Regulating Zn2+ Homeostasis via Autophagy [23NFSC2298]
FX Chengdu Suppoorted by Sichuan Provincial Administration of Traditional
   Chinese Medicine Key Project of Scientific Research in Traditional
   Chinese Medicine: Deep Learning-based Three-dimensional Finite Element
   Analysis of Pestle Needle Therapy for the Treatment of Cervical Spine
   Physiologic Curvature Abnormalities (2023zd025) ; Scientific Research
   Project of Sichuan Provincial Science and Technology Department:
   Improvement of cartilage Degeneration in Knee Osteoarthritis by
   Regulating Zn2+ Homeostasis via Autophagy in Duhuo Jisheng Decoction
   (23NFSC2298)
CR Almada AE, 2016, NAT REV MOL CELL BIO, V17, P267, DOI 10.1038/nrm.2016.7
   Blanpied Peter R, 2017, J Orthop Sports Phys Ther, V47, pA1, DOI [10.2519/jospt.2017.0302, 10.2519/jospt.2017.0302]
   Cagnie B, 2012, EUR J APPL PHYSIOL, V112, P3305, DOI 10.1007/s00421-012-2322-z
   Chu Y, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms252211901
   Dingyue W, 2024, J TRADIT CHIN MED, V44, P629, DOI 10.19852/j.cnki.jtcm.20240322.001
   Fernando P, 2002, P NATL ACAD SCI USA, V99, P11025, DOI 10.1073/pnas.162172899
   Fiacco E, 2016, CELL DEATH DIFFER, V23, P1839, DOI 10.1038/cdd.2016.70
   Gao H, 2023, Hua Zhong Ke Ji Da Xue Xue Bao, V52, P458
   García-Prat L, 2016, NATURE, V529, P37, DOI 10.1038/nature16187
   Goh Q, 2017, ELIFE, V6, DOI 10.7554/eLife.20007
   Guo Y, 2016, Experimental acupuncture, P40
   Harrington JS, 2023, PHYSIOL REV, V103, P2349, DOI 10.1152/physrev.00058.2021
   Hu Y, 2018, Chengdu Zhong Yi Yao Da Xue Xue Bao, V41, P112
   Japaries W, 2022, MED ACUPUNCT, V34, P400, DOI 10.1089/acu.2021.0051
   Ji YA, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11091686
   Jiang ZY, 2001, Zhong Guo Zhen Jiu, V21, P30
   Jin S, 2019, Pestle needle therapy and sports injuries, P80
   Kazeminasab S, 2022, BMC MUSCULOSKEL DIS, V23, DOI 10.1186/s12891-021-04957-4
   Kim I, 2007, ARCH BIOCHEM BIOPHYS, V462, P245, DOI 10.1016/j.abb.2007.03.034
   Li B, 2019, STEM CELL RES THER, V10, DOI 10.1186/s13287-019-1219-8
   Li HT, 2021, Zhen Jiu Lin Chuang Za Zhi, V37, P85
   Li YC, 2022, Zhong Hua Zhong Yi Yao Xue Kan, V40, P210
   Li ZB, 2012, J CELL SCI, V125, P3957, DOI 10.1242/jcs.090365
   Liu FS, 2012, Effects of acupotomy therapy on apoptosis in posterior cervical extensor muscles in rabbit cervical spondylosis model, P43
   [刘福水 Liu Fushui], 2020, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V35, P918
   Liu JY, 2023, Zhong Guo Lin Chuang Yan Jiu Za Zhi, V36, P134
   Ma HF, 2023, Zhong Guo Zu Zhi Gong Cheng Yan Jiu, V27, P1842
   Mahdy MAA, 2019, CELL TISSUE RES, V375, P575, DOI 10.1007/s00441-018-2955-2
   McArthur K, 2018, SCIENCE, V359, P883, DOI 10.1126/science.aao6047
   Nagata S, 2018, ANNU REV IMMUNOL, V36, P489, DOI 10.1146/annurev-immunol-042617-053010
   Rao RD, 2007, J BONE JOINT SURG AM, V89A, P1360
   Romanov J, 2012, EMBO J, V31, P4304, DOI 10.1038/emboj.2012.278
   Schaaf MBE, 2016, FASEB J, V30, P3961, DOI 10.1096/fj.201600698R
   Shen ZF, 2015, Shanghai Zhen Jiu Za Zhi, V34, P575
   [史红美 Shi Hongmei], 2019, [时珍国医国药, Lishizhen Medicine and Materia Medica Research], V30, P1526
   Singh R, 2019, NAT REV MOL CELL BIO, V20, P175, DOI 10.1038/s41580-018-0089-8
   Strom V, 2009, PAIN, V144, P147, DOI 10.1016/j.pain.2009.04.002
   Theodore N, 2020, NEW ENGL J MED, V383, P159, DOI 10.1056/NEJMra2003558
   Wang BY, 2024, J TRADIT CHIN MED, V44, P1091, DOI 10.19852/j.cnki.jtcm.20240926.001
   Wang X, 2020, J INTEGR MED-JIM, V18, P492, DOI 10.1016/j.joim.2020.08.001
   [Wang Yanzhi 王延之], 2016, [Journal of Acupuncture and Tuina Science, 针灸推拿医学], V14, P284, DOI 10.1007/s11726-016-0937-z
   Wang YX, 2012, NAT REV MOL CELL BIO, V13, P127, DOI 10.1038/nrm3265
   Wang YQ, 2012, AUTOPHAGY, V8, P1462, DOI 10.4161/auto.21211
   Xiong Shou-liang, 2013, Zhonghua Yi Xue Za Zhi, V93, P2474
   Xu HG, 2014, EXP THER MED, V7, P537, DOI 10.3892/etm.2013.1465
   Xu QF, 2023, MINERVA PEDIATR, V75, P930, DOI [10.23736/S2724-5276.23.07300-7, 10.23736/S2724-5276.23.07303-2]
   [徐善达 Xu Shanda], 2020, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V35, P4739
   Yeh ML, 2010, ALTERN THER HEALTH M, V16, P10
   Zhang GL, 2019, Shi Jie Zui Xin Yi Xue Xin Xi Wen Zhai, V19, P142
   Zhang X, 2015, Zhong Hua Zhong Yi Yao Xue Kan, V33, P913
   Zhen YL, 2003, Shanghai Zhen Jiu Za Zhi, P26
   Zhong L, 2017, Diagram of Sichuan Li's clinical experience on pestle needling, P23
   Zhong SC, 2006, The pestle needle, P83
NR 53
TC 0
Z9 0
U1 4
U2 4
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PY 2025
VL 45
IS 4
BP 786
EP 795
DI 10.19852/j.cnki.jtcm.2025.04.009
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 5YP4E
UT WOS:001547438600001
PM 40810224
DA 2026-01-16
ER

PT J
AU Luh, C
   Eckstrom, E
AF Luh, Colin
   Eckstrom, Elizabeth
TI Perceptions That Influence Acupuncture Use in Hospice Settings: Results
   of a State-Wide Survey Study
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE acupuncture; hospice; barriers
ID RADIATION-INDUCED XEROSTOMIA; PALLIATIVE CARE; CONTROLLED-TRIAL; CANCER;
   CHEMOTHERAPY; PAIN; EFFICACY; SAFETY; MANAGEMENT; CHILDREN
AB Background: Acupuncture is an effective and low-risk therapy for a wide spectrum of medical conditions. In the hospice setting, where comfort is the top priority, acupuncture could play a vital role in reducing symptom burden at the end of life.
   Objective: This state-wide survey study explored perceived barriers to acupuncture use in the hospice setting from acupuncturist and hospice staff perspectives. Specific barriers addressed included insurance coverage/funding for acupuncture, lack of knowledge of acupuncture as a therapeutic modality, and perceived insufficient evidence base for acupuncture.
   Materials and Methods: Acupuncturists and hospice staff in Oregon were recruited by e-mail and/or telephone to complete their survey.
   Results: Among acupuncturists, a response rate of 50% was obtained. The response rate of hospice staff could not be obtained. There were a total of 270 providers and hospice staff (102 acupuncturists, 16 hospice doctors, 14 hospice directors, 93 hospice nurses, 30 hospice social workers, and 15 hospice chaplains). The majority of acupuncturists (76% and 89%, respectively) and hospice staff (59% and 82%, respectively) strongly agreed or somewhat agreed that insurance coverage/funding for acupuncture and lack of knowledge of acupuncture as a therapeutic modality are important barriers. With respect to the perceived evidence base for acupuncture, the majority of acupuncturists (91%) and hospice staff (69%) strongly agreed or somewhat agreed that acupuncture can help provide a higher quality of life for hospice patients, although knowledge of specific conditions amenable to acupuncture among acupuncturists and hospice staff varied.
   Conclusions: From the acupuncturist and hospice staff perspectives, insurance coverage/funding for acupuncture, lack of knowledge of acupuncture as a therapeutic modality, and perceived insufficient evidence base for acupuncture are primary barriers to the use of acupuncture in hospice care. Increased awareness/education about acupuncture in the hospice setting, as well as improved funding structures, is critical.
C1 [Luh, Colin] OHSU Sch Med, Portland, OR 97209 USA.
   [Eckstrom, Elizabeth] OHSU Div Gen Internal Med & Geriatr, Portland, OR USA.
C3 Oregon Health & Science University
RP Luh, C (corresponding author), OHSU Sch Med, Portland, OR 97209 USA.
EM colinluh@hotmail.com
FU Cambia Health Foundation; OHSU School of Medicine
FX The funding for this study was provided by the OHSU School of Medicine
   (for assistance with statistical analyses) and the Cambia Health
   Foundation (a philanthropic award).
CR Adams D, 2011, PEDIATRICS, V128, pE1575, DOI 10.1542/peds.2011-1091
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   AUNG S, 1994, ACUPUNCT MED, V12, P37
   Birch S, 2004, J ALTERN COMPLEM MED, V10, P468, DOI 10.1089/1075553041323894
   Blom M, 1996, ORAL ONCOL, V32B, P182
   Chen L, 2010, PAIN MED, V11, P530, DOI 10.1111/j.1526-4637.2010.00815.x
   Dang W, 1998, J Tradit Chin Med, V18, P31
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Demmer Craig, 2004, J Palliat Med, V7, P510, DOI 10.1089/1096621041838335
   DUNDEE JW, 1989, J ROY SOC MED, V82, P268, DOI 10.1177/014107688908200508
   Ezzo J, 2005, J CLIN ONCOL, V23, P7188, DOI 10.1200/JCO.2005.06.028
   Filshie J, 2001, Acupunct Med, V19, P117
   Filshie J, 1996, PALLIATIVE MED, V10, P145, DOI 10.1177/026921639601000209
   FILSHIE J, 1990, ACUPUNCT MED, V8, P38
   Braga FDF, 2011, BRAZ ORAL RES, V25, P180
   Gadsby J.G., 1997, Complementary Ther Med, V5, P13, DOI [10.1016/S0965-2299(97)80084-2, DOI 10.1016/S0965-2299(97)80084-2]
   Jindal V, 2008, J PEDIAT HEMATOL ONC, V30, P431, DOI 10.1097/MPH.0b013e318165b2cc
   JOBST K, 1986, LANCET, V2, P1416, DOI 10.1016/S0140-6736(86)92732-7
   Johnstone PAS, 2002, CANCER, V94, P1151, DOI 10.1002/cncr.10348
   Korak LE, 2008, AM J HOSP PALLIAT ME, V25, P463, DOI 10.1177/1049909108322292
   Lau CHY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002901
   Lee A, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003281.pub3
   Lee H, 2005, EUR J PAIN, V9, P437, DOI 10.1016/j.ejpain.2004.10.004
   Leng G, 1999, PALLIATIVE MED, V13, P163, DOI 10.1191/026921699676243035
   Leng G, 2013, ACUPUNCT MED, V31, P16, DOI 10.1136/acupmed-2012-010230
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Lytle C.D., 1993, OVERVIEW ACUPUNCTURE
   MANN F, 1973, LANCET, V2, P57
   Mansky PJ, 2006, CANCER J, V12, P425, DOI 10.1097/00130404-200609000-00011
   Meidell L, 2009, INT J PALLIAT NURS, V15, P12, DOI 10.12968/ijpn.2009.15.1.37947
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P228, DOI 10.1016/j.ctim.2006.09.009
   Rydholm M, 1999, J PALLIATIVE CARE, V15, P20, DOI 10.1177/082585979901500404
   Shafto K, 2018, CHILDREN-BASEL, V5, DOI 10.3390/children5060075
   Shen JN, 2000, JAMA-J AM MED ASSOC, V284, P2755, DOI 10.1001/jama.284.21.2755
   Simcock R, 2009, ACUPUNCT MED, V27, P109, DOI 10.1136/aim.2009.000935
   Standish LJ, 2008, AM J HOSP PALLIAT ME, V25, P298, DOI 10.1177/1049909108315916
   Suzuki M, 2012, ARCH INTERN MED, V172, P878, DOI 10.1001/archinternmed.2012.1233
   Towler P, 2013, SUPPORT CARE CANCER, V21, P2913, DOI 10.1007/s00520-013-1882-8
   Vickers A, 2002, QUAL SAF HEALTH CARE, V11, P92, DOI 10.1136/qhc.11.1.92
   Vickers AJ, 2004, J CLIN ONCOL, V22, P1731, DOI 10.1200/JCO.2004.04.102
   Vickers AJ, 1996, J ROY SOC MED, V89, P303, DOI 10.1177/014107689608900602
   WEN HL, 1977, MOD MED ASIA, V13, P12
   Wright Leonard D, 2005, Am J Hosp Palliat Care, V22, P49, DOI 10.1177/104990910502200111
   Wu XL, 2015, SCI REP-UK, V5, DOI [10.1038/srep11728, 10.1038/srep16776]
   Yang CS, 2015, PEDIATR RES, V78, P112, DOI 10.1038/pr.2015.91
   Yang J., 1990, ACUPUNCT MED, V7, P2
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 47
TC 2
Z9 2
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD SEP 1
PY 2021
VL 27
IS 9
BP 760
EP 770
DI 10.1089/acm.2021.0028
EA JUN 2021
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA UP8ZQ
UT WOS:000661610300001
PM 34129378
DA 2026-01-16
ER

PT J
AU Smith, CL
   Reddy, B
   Wolf, CM
   Schnyer, RN
   St John, K
   Conboy, L
   Stone, J
   Lao, LX
AF Smith, Clasina Leslie
   Reddy, Bill
   Wolf, Charis M.
   Schnyer, Rosa N.
   St John, Korina
   Conboy, Lisa
   Stone, Jen
   Lao, Lixing
TI The State of 21st Century Acupuncture in the United States
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE acupuncture; herbal medicine; traditional Chinese medicine; integrative
   medicine; integrative health; medical policy
ID EVENTS FOLLOWING ACUPUNCTURE; TRADITIONAL CHINESE MEDICINE; INTEGRATIVE
   MEDICINE; PAIN MANAGEMENT; LICENSED ACUPUNCTURISTS; AURICULAR
   ACUPUNCTURE; EMERGENCY-DEPARTMENT; COST-EFFECTIVENESS; NEURAL MECHANISM;
   SHAM ACUPUNCTURE
AB The term "acupuncture" commonly refers to a non-pharmacologic therapy that is increasingly employed by diverse segments of the population for a wide variety of complaints including pain, insomnia, anxiety, depression, frozen shoulder, and other issues. The term is also used as a short-hand for the wider medical system from which the placement of needles into the skin for therapeutic benefit and related techniques evolved. Thus "acupuncture" refers both to the therapeutic technique and the therapeutic system of Acupuncture and Herbal Medicine (AHM). The other modalities included within AHM include a wide variety of physical and mechanical manipulations, herbal medicines, dietary recommendations, and lifestyle modifications. Clinically, acupuncture is increasingly offered in a variety of conventional medical settings such as hospitals, medical school clinics, veterans' healthcare centers, oncology facilities, and rehabilitation centers, and its safety profile is excellent overall. Barriers to further incorporation of acupuncture into biomedical sites include insurance coverage of acupuncture, education of conventional medical practitioners and other stakeholders about the utility, efficacy, and evidence base of acupuncture. Acupuncturists in the United States are skilled practitioners who are highly educated in the complex therapeutic system from which acupuncture arose and in the technical aspects of its utility as a treatment modality. The training, certification, licensure, and regulation of acupuncturists is similar to that of conventional providers such has physician's assistants, advanced practice nurses, and medical and osteopathic doctors. While clinical use and acceptance of acupuncture continues to grow, there is to date no definitive composite document explaining the utility of acupuncture in various healthcare settings, the current understanding of how acupuncture works, and the training, professional regulation, and certification of acupuncture practitioners. This article will address these topics and strive to create a reference for practitioners, administrators, legislators, insurance providers, patients and their families, and other stakeholders.
C1 [Smith, Clasina Leslie] Chicago Healing Ctr, 1560 N Sandburg Ter,Unit 3215, Chicago, IL 60610 USA.
   [Smith, Clasina Leslie] Southern Illinois Univ, Sch Med, Springfield, IL USA.
   [Reddy, Bill] Vital Point Acupuncture, Annandale, VA USA.
   [Wolf, Charis M.; Conboy, Lisa] Seattle Inst East Asian Med, Seattle, WA USA.
   [Wolf, Charis M.] Middle Way Acupuncture Inst, Seattle, WA USA.
   [Schnyer, Rosa N.] Univ Texas Austin, Sch Nursing, Austin, TX USA.
   [Schnyer, Rosa N.; Conboy, Lisa] Oregon Coll Oriental Med, Portland, OR USA.
   [St John, Korina] Modern Med Woman LLC, Palmer, AK USA.
   [Conboy, Lisa] Harvard Med Sch, Beth Deaconess Med Ctr, Boston, MA USA.
   [Conboy, Lisa] Calif Inst Integral Studies, San Francisco, CA USA.
   [Conboy, Lisa] Pacific Coll Oriental Med, San Diego, CA USA.
   [Conboy, Lisa] YoSan Univ, Los Angeles, CA USA.
   [Conboy, Lisa] Five Branches Univ, Santa Cruz, CA USA.
   [Conboy, Lisa] Amer Acad Hlth & Wellness, Roseville, MN USA.
   [Stone, Jen] Indiana Univ Sch Med, ICTSI, Indianapolis, IN USA.
   [Lao, Lixing] Virginia Univ Integrat Med, Vienna, VA USA.
   [Lao, Lixing] Univ Maryland, Sch Med, Baltimore, MD USA.
   [Lao, Lixing] Univ Hong Kong, Sch Chinese Med, Pokfulam, Hong Kong, Peoples R China.
C3 Southern Illinois University System; Southern Illinois University;
   University of Texas System; University of Texas Austin; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; Indiana University
   System; Indiana University Bloomington; University System of Maryland;
   University of Maryland Baltimore; University of Hong Kong
RP Smith, CL (corresponding author), Chicago Healing Ctr, 1560 N Sandburg Ter,Unit 3215, Chicago, IL 60610 USA.
EM LeslieTCM@gmail.com
RI ; Lao, Lixing/P-9107-2019; Reddy, Bill/MCK-0081-2025
OI Wolf, Charis M/0000-0002-8160-5858; 
CR Acupuncture AAoM, 2024, Ongoing Courses, Colleges and Medical Acupuncture training
   Acupuncturists ASo, 2021, 2021 state of the profession report, P32
   Adams D, 2011, PEDIATRICS, V128, pE1575, DOI 10.1542/peds.2011-1091
   Administration USFaD, Complementary and alternative medicine products and their regulation by the food and drug administration
   Amorim D, 2018, COMPLEMENT THER CLIN, V31, P31, DOI 10.1016/j.ctcp.2018.01.008
   [Anonymous], 2006, CBS NEWS
   [Anonymous], Association AVM Complementary, alternative, and integrative veterinary medicine
   [Anonymous], 2023, Occupational Employment and Wages, Agricultural Workers
   [Anonymous], University B Doctor of acupuncture program overview
   Association AM, 2016, Policy finders: practice parameters: dry needling
   Bäumler P, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-045961
   BAO K, 1992, AM J CHINESE MED, V20, P191, DOI 10.1142/S0192415X92000205
   Bao T, 2018, ACUPUNCT MED, V36, P80, DOI 10.1136/acupmed-2017-011435
   Barnes Patricia M, 2004, Adv Data, P1
   Barnes Patricia M, 2008, Natl Health Stat Report, P1
   Benrick A, 2020, J CLIN ENDOCR METAB, V105, P2027, DOI 10.1210/clinem/dgaa165
   Bettini E, 2023, CANCER NURS, V46, pE204, DOI 10.1097/NCC.0000000000001135
   Birch Stephen., 1999, UNDERSTANDING ACUPUN
   Bleck RR, 2021, ACUPUNCT MED, V39, P327, DOI 10.1177/0964528420939576
   Boleta-Ceranto Daniela de Cassia Faglioni, 2014, Dental Press J. Orthod., V19, P100
   Boyce D, 2020, INT J SPORTS PHYS TH, V15, P103, DOI 10.26603/ijspt20200103
   Burns JR, 2019, J PATIENT-CENTER RES, V6, P172, DOI 10.17294/2330-0698.1688
   Candon M, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2021.42509
   CASSEDY JH, 1974, B NEW YORK ACAD MED, V50, P892
   Chan MWC, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03272-0
   Charles JC, 2023, More patients pick acupuncture society of hospital medicine
   Chen LZ, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.695152
   Chen T, 2020, AM J CHINESE MED, V48, P793, DOI 10.1142/S0192415X20500408
   Chiang P, 2015, MED ACUPUNCT, V27, P67, DOI 10.1089/acu.2015.1093
   Chiwandamira F, 2023, ADV EMERG NURS J, V45, P321, DOI 10.1097/TME.0000000000000487
   Choi SY, 2022, J KOREAN ACAD NURS, V52, P4, DOI 10.4040/jkan.21121
   Choi TY, 2022, CANCERS, V14, DOI 10.3390/cancers14184419
   Chokshi SK, 2017, PEDIATR BLOOD CANCER, V64, DOI 10.1002/pbc.26424
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   Cohen L, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.10421
   Commission OLS, 2021, Ohio Administrative Code Rule 5160-8-51 Acupuncture Services
   Cotton S, 2014, J ALTERN COMPLEM MED, V20, P98, DOI 10.1089/acm.2013.0306
   DeBar LL, 2023, CONTEMP CLIN TRIALS, V128, DOI 10.1016/j.cct.2023.107166
   Deng G, 2019, CANCER J, V25, P343, DOI 10.1097/PPO.0000000000000399
   Di Francesco F, 2024, BMC ORAL HEALTH, V24, DOI 10.1186/s12903-023-03806-1
   Ding SS, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/6671195
   Dusek JA, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000028961
   Dusek JA, 2018, J ALTERN COMPLEM MED, V24, P557, DOI 10.1089/acm.2017.0203
   Ellingsen DM, 2020, SCI ADV, V6, DOI 10.1126/sciadv.abc1304
   Epstein AS, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.42482
   Ernst E, 2001, AM J MED, V110, P481, DOI 10.1016/S0002-9343(01)00651-9
   Ezzo J, 2005, J CLIN ONCOL, V23, P7188, DOI 10.1200/JCO.2005.06.028
   Fan AY, 2019, J INTEGR MED-JIM, V17, P315, DOI 10.1016/j.joim.2019.06.003
   Fan AY, 2018, COMPLEMENT THER MED, V41, P295, DOI 10.1016/j.ctim.2018.10.015
   Fan AY, 2017, CHIN J INTEGR MED, V23, P83, DOI 10.1007/s11655-017-2800-6
   Fan AY, 2016, J ALTERN COMPLEM MED, V22, P591, DOI 10.1089/acm.2016.0066
   Fang CY, 2019, J DENT SCI, V14, P81, DOI 10.1016/j.jds.2018.11.003
   Feng SY, 2015, AM J RHINOL ALLERGY, V29, P57, DOI 10.2500/ajra.2015.29.4116
   Fernández-Hernando D, 2023, FRONT NEUROSCI-SWITZ, V17, DOI 10.3389/fnins.2023.1151892
   Foundation AN, 2023, Acupuncture in Hospitals 2020
   GAW AC, 1975, NEW ENGL J MED, V293, P375, DOI 10.1056/NEJM197508212930803
   Goldman N, 2010, NAT NEUROSCI, V13, P883, DOI 10.1038/nn.2562
   Grahl A, 2022, J PAIN, V23, P44
   Groppetti D, 2011, BRIT J ANAESTH, V107, P612, DOI 10.1093/bja/aer199
   da Silva JBG, 2014, EUR J INTEGR MED, V6, P488, DOI 10.1016/j.eujim.2013.12.022
   Han JS, 2011, PAIN, V152, pS41, DOI 10.1016/j.pain.2010.10.012
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   HAN JS, 1991, PAIN, V47, P295, DOI 10.1016/0304-3959(91)90218-M
   Hao Jason Jishun, 2014, Glob Adv Health Med, V3, P6, DOI 10.7453/gahmj.2014.042
   Harder B, 2022, U.S. News and World Report
   Harris RE, 2009, NEUROIMAGE, V47, P1077, DOI 10.1016/j.neuroimage.2009.05.083
   Haywood S, 2019, MED ACUPUNCT, V31, P224, DOI 10.1089/acu.2019.1358
   He W, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/786839
   Health ACfIMa, 2024, Academic Consortium for Integrative Medicine and Health Member Listing
   Health NCfCa I, 2024, Acupuncture: what you need to know
   Henkel G, 2012, Survey: steady Increase in Complementary Alternative Medicine (CAM) Offerings in U.S. Hospitals
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Ho KY, 2025, CANCER NURS, V48, P89, DOI 10.1097/NCC.0000000000001239
   Hoffmann B, 2022, AUST DENT J, V67, pS3, DOI 10.1111/adj.12926
   Holley SE, 2020, How acupuncture became a radical remedy in the Bronx
   Hollifield M, 2024, JAMA PSYCHIAT, V81, P545, DOI 10.1001/jamapsychiatry.2023.5651
   Huang WJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032960
   Huang XY, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/9651592
   Ijaz N, 2024, FRONT MED-LAUSANNE, V11, DOI 10.3389/fmed.2024.1409392
   Irnich D, 2002, PAIN, V99, P83, DOI 10.1016/S0304-3959(02)00062-3
   Jan YM, 2010, AM J CHINESE MED, V38, P441, DOI 10.1142/S0192415X10007968
   Jin GY, 2024, WORLD J ACUPUNCT-MOX, V34, P1, DOI 10.1016/j.wjam.2023.05.005
   Jin ZR, 2021, THERANOSTICS, V11, P2822, DOI 10.7150/thno.51869
   Johnstone PAS, 2002, PALLIATIVE MED, V16, P235, DOI 10.1191/0269216302pm540oa
   Kawakita K, 2014, BIOPSYCHOSOC MED, V8, DOI 10.1186/1751-0759-8-4
   Kemper KJ, 2000, PEDIATRICS, V105, P941
   Kim SY, 2012, ACUPUNCT MED, V30, P273, DOI 10.1136/acupmed-2012-010178
   Kimura A, 1997, JPN J VET RES, V45, P137
   Kokosar M, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-17919-5
   Koo ST, 2008, PAIN, V135, P11, DOI 10.1016/j.pain.2007.04.034
   Kwak HY, 2023, HEALTHCARE-BASEL, V11, DOI 10.3390/healthcare11222957
   Kwon S, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/8042198
   Lai HC, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6173412
   Lam WC, 2019, PHARM MED, V33, P373, DOI 10.1007/s40290-019-00295-y
   Langevin HM, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1155/2011/180805
   Langevin HM, 2006, J CELL PHYSIOL, V207, P767, DOI 10.1002/jcp.20623
   Langevin HM, 2002, FASEB J, V16, P872, DOI 10.1096/fj.01-0925fje
   Lee M, 2018, COMPLEMENT THER MED, V41, P23, DOI 10.1016/j.ctim.2018.08.006
   Lee S, 2022, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.947884
   Lee YS, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/2948292
   Leem J, 2015, INTEGR MED RES, V4, P119, DOI 10.1016/j.imr.2015.04.001
   Legge D, 2014, J MUSCULOSKELET PAIN, V22, P301, DOI 10.3109/10582452.2014.883041
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Leung KK, 2022, PHYTOMEDICINE, V104, DOI 10.1016/j.phymed.2022.154254
   Li BX, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2023.52580
   Li HY, 2021, CHINESE MED J-PEKING, V134, P2365, DOI 10.1097/CM9.0000000000001796
   Li MC, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000030076
   Li NC, 2021, J INFLAMM RES, V14, P7191, DOI 10.2147/JIR.S341581
   Li PS, 2023, FERTIL STERIL, V119, P815, DOI 10.1016/j.fertnstert.2023.01.034
   Li QW, 2020, CHIN MED-UK, V15, DOI 10.1186/s13020-020-00333-x
   Li YQ, 2007, WORLD J GASTROENTERO, V13, P709, DOI 10.3748/wjg.v13.i5.709
   Liang Q, 2020, AM J CHINESE MED, V48, P1769, DOI 10.1142/S0192415X20500883
   Lim Nan-Young, 2003, Taehan Kanho Hakhoe Chi, V33, P79
   Lin JG, 2022, AM J TRANSL RES, V14, P1469
   Lin K, 2017, MED ACUPUNCT, V29, P121, DOI 10.1089/acu.2017.1235
   Lin Y-CT, Cynthia. Providing needleless acupuncture telemedicine during COVID-19
   Liou KT, 2021, SUPPORT CARE CANCER, V29, P427, DOI 10.1007/s00520-020-05504-y
   Liu SB, 2021, NATURE, V598, P641, DOI 10.1038/s41586-021-04001-4
   Liu SB, 2020, NEURON, V108, P436, DOI 10.1016/j.neuron.2020.07.015
   Liu WL, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420928490
   Liu WL, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419848494
   Lopez G, 2018, J CANCER, V9, P3613, DOI 10.7150/jca.26527
   Lu DP, 2013, MED ACUPUNCT, V25, P311, DOI 10.1089/acu.2012.0921
   Ma Y, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168123
   MacDonald IJ, 2021, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.594219
   MacPherson H, 2017, PAIN, V158, P784, DOI 10.1097/j.pain.0000000000000747
   MacPherson H, 2001, BMJ-BRIT MED J, V323, P486, DOI 10.1136/bmj.323.7311.486
   MacPherson H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093739
   Maeda Y, 2017, BRAIN, V140, P914, DOI 10.1093/brain/awx015
   Mao JJ, 2021, JAMA ONCOL, V7, P720, DOI 10.1001/jamaoncol.2021.0310
   Mao JJ, 2023, J INTEGR COMPLEMENT, V29, P209, DOI 10.1089/jicm.2023.0018
   Mcculloch Michael, 2015, Perm J, V19, P68, DOI 10.7812/TPP/14-057
   McDonald JL, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/591796
   Medicare, Your Medicare Coverage, Hearing Aids
   Medicine ACfAaH, 2024, Home Page
   Medicine ACfAaH, Policies: program naming. accreditation commission for acupuncture and herbal medicine
   Medicine CoCoAaH, 2024, Mission, vision, goals and core values
   Medicine NCCfAa O, Home page. national certification commission for acupuncture and oriental medicine
   Medicine TACotAo IH, Integrative Centers with status as PCMHs or as FQHC
   Misra SM, 2019, CLIN PEDIATR, V58, P738, DOI 10.1177/0009922819839232
   Mozafari PM, 2022, J EVID-BASED DENT PR, V22, DOI 10.1016/j.jebdp.2022.101733
   Nahin RL, 2024, JAMA-J AM MED ASSOC, V331, P613, DOI 10.1001/jama.2023.26775
   Nahin Richard L, 2016, Natl Health Stat Report, P1
   Nahin Richard L, 2009, Natl Health Stat Report, P1
   Naik PN, 2014, MED ACUPUNCT, V26, P308, DOI 10.1089/acu.2014.1028
   Napadow V, 2023, J INTEGR COMPLEMENT, V29, P769, DOI 10.1089/jicm.2023.0592
   Nardini C, 2014, SCIENCE, V346, pS21
   Nawaz H, 2015, AM J PREV MED, V49, pS296, DOI 10.1016/j.amepre.2015.07.010
   Nielsen A, 2022, PAIN MED, V23, P1582, DOI 10.1093/pm/pnac056
   Nielsen A, 2020, PAIN MED, V21, P1276, DOI 10.1093/pm/pnz379
   Niemtzow RC, 2000, CURR PROB CANCER, V24, P184
   Olson J, 2024, AM AC MED AC ANN S M
   Olson JL, 2018, MED ACUPUNCT, V30, P248, DOI 10.1089/acu.2018.1298
   Omura Y, 1982, Acupuncture Medicine: Its Historical and Clinical Background
   Painovich J, 2012, EVID-BASED COMPL ALT, V2012, P1, DOI 10.1155/2012/309762
   Pak ME, 2018, EXP NEUROL, V300, P222, DOI 10.1016/j.expneurol.2017.11.014
   Pan CX, 2000, J PAIN SYMPTOM MANAG, V20, P374, DOI 10.1016/S0885-3924(00)00190-1
   Pang B, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/3862916
   Park JY, 2018, J INFLAMM RES, V11, P227, DOI 10.2147/JIR.S141198
   Pei LX, 2020, MAYO CLIN PROC, V95, P1671, DOI 10.1016/j.mayocp.2020.01.042
   Pock AR, 2011, MED ACUPUNCT, V23, P205, DOI 10.1089/acu.2011.0835
   Priebe T, 2017, J INTEGR MED-JIM, V15, P165, DOI 10.1016/S2095-4964(17)60338-8
   Public IoMUSCotUoCaAMbtA, Integration of Complementary and Alternative Medicine (CAM) and Conventional Medicine
   Quifu Ma SN, Acupuncture for Pain Relief. Fact Sheet
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Reddy B., 2021, Telephone conversation between Mina Larson, CEO of NCCAOM and Bill Reddy, LAc. on 01/18/ 2021 regarding the number of certifications NCCAOM has issued for acupuncture and the number of certificates issued for Oriental medicine
   Reddy B, 2022, BMC MED INFORM DECIS, V21, DOI 10.1186/s12911-022-01913-7
   Reddy KP, 2018, MED ACUPUNCT, V30, P225, DOI 10.1089/acu.2018.29096.rdk
   Reinstein AS, 2017, PAIN MED, V18, P169, DOI 10.1093/pm/pnv114
   Reston J., 1971, The New York Times
   Sandberg M, 2003, EUR J APPL PHYSIOL, V90, P114, DOI 10.1007/s00421-003-0825-3
   Seem Mark., 2000, Acupuncture Physical Medicine
   Serafini K, 2016, ACAD PSYCHIATR, V40, P503, DOI 10.1007/s40596-015-0342-9
   Services CfMaM, 2024, Billing and Coding: pain Management
   Services USDoHaH, 2023, PART 880-GENERAL HOSPITAL AND PERSONAL USE DEVICES; Subpart F-General Hospital and Personal Use Therapeutic Devices; Sec. 880.5580 Acupuncture needle
   Shang C, 2000, Med Acupunct Online J, V11, P61
   Shang C, 2009, EVID-BASED COMPL ALT, V6, P31, DOI 10.1093/ecam/nem122
   Shapiro H., 2006, Medicine Across Cultures: History and Practice of Medicine in Non-western Cultures
   Shergis JL, 2016, COMPLEMENT THER MED, V26, P11, DOI 10.1016/j.ctim.2016.02.007
   Sherman KJ, 2005, ANN FAM MED, V3, P151, DOI 10.1370/afm.248
   Shi GX, 2012, TRIALS, V13, DOI 10.1186/1745-6215-13-42
   Simons DG., 1999, Travell and Simons' Myofascial Pain and Dysfunction: the Trigger Point Manual, V2nd
   Smith CL, 2024, MED ACUPUNCT, V36, P27, DOI 10.1089/acu.2023.0009
   Society IVA, 2024, Veterinary Acupuncture Courses
   Sun YJ, 2021, ANN INTERN MED, V174, P1357, DOI 10.7326/M21-1814
   Takano T, 2012, J PAIN, V13, P1215, DOI 10.1016/j.jpain.2012.09.012
   Takayama S, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/513638
   Tick H, 2018, EXPLORE-NY, V14, P177, DOI 10.1016/j.explore.2018.02.001
   Traeger Adrian C, 2021, JAMA, V326, P286, DOI [10.1001/jama.2020.19715, 10.1001/jama.2020.19715]
   Travell J, 1942, J AMER MED ASSOC, V120, P417, DOI 10.1001/jama.1942.02830410005002
   Tsai SL, 2018, MED ACUPUNCT, V30, P61, DOI 10.1089/acu.2018.29075.rtl
   Tu JF, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.25735
   Tu JF, 2021, ARTHRITIS RHEUMATOL, V73, P448, DOI 10.1002/art.41584
   Uchida S, 2017, AUTON NEUROSCI-BASIC, V203, P1, DOI 10.1016/j.autneu.2016.11.001
   Upchurch DM, 2014, J ALTERN COMPLEM MED, V20, P32, DOI 10.1089/acm.2012.0120
   Usichenko TI, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.0517
   Veleber S, 2024, INTEGR CANCER THER, V23, DOI 10.1177/15347354241226640
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Ward-Cook K., 2017, MERIDIANS J ACUPUNCT, V3, P13
   Weeks John, 2017, Integr Med (Encinitas), V16, P18
   Wehler CJ, 2021, J AM DENT ASSOC, V152, P641, DOI 10.1016/j.adaj.2021.03.022
   White A, 2001, BRIT MED J, V323, P485, DOI 10.1136/bmj.323.7311.485
   White Adrian, 2004, Acupunct Med, V22, P122
   Willich SN, 2006, PAIN, V125, P107, DOI 10.1016/j.pain.2006.06.006
   Witt CM, 2011, PAIN, V152, P2180, DOI 10.1016/j.pain.2011.04.010
   Witt CM, 2011, EUR J PAIN, V15, P193, DOI 10.1016/j.ejpain.2010.06.008
   Witt CM, 2009, FORSCH KOMPLEMENTMED, V16, P91, DOI 10.1159/000209315
   Wong R, 2001, CANCER TREAT REV, V27, P235, DOI 10.1053/ctrv.2001.0227
   World Health Organization, 2024, What is the Traditional Medicine Chapter of ICD-11
   World Health Organization, 2024, Initiatives: WHO global traditional medicine centre
   World Health Organization, 2024, WHO international standard terminologies on traditional Chinese medicine
   Worstell C, 2021, Medicare Advantage
   Wu JY, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/432467
   Xu SF, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/581203
   Yan MY, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.17862
   Yang JH, 2009, J KOREAN ACAD NURS, V39, P10, DOI 10.4040/jkan.2009.39.1.10
   Yang JW, 2022, ECLINICALMEDICINE, V49, DOI 10.1016/j.eclinm.2022.101472
   Yang JW, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/739708
   Ye X, 2017, J INTEGR MED-JIM, V15, P344, DOI 10.1016/S2095-4964(17)60357-1
   Ye Z, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0271580
   Yin C, 2017, CURR OPIN ANESTHESIO, V30, P583, DOI 10.1097/ACO.0000000000000501
   Yin X, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.20563
   Zeliadt SB, 2020, MED CARE, V58, pS101, DOI 10.1097/MLR.0000000000001368
   Zhang JL, 2023, BREAST CANCER RES, V25, DOI 10.1186/s13058-023-01645-0
   Zhang RX, 2014, ANESTHESIOLOGY, V120, P482, DOI 10.1097/ALN.0000000000000101
   Zhang Y, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/710750
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zheng H, 2022, NEUROLOGY, V99, pE1560, DOI 10.1212/WNL.0000000000200670
   Zhuang Y, 2013, INT REV NEUROBIOL, V111, P1, DOI 10.1016/B978-0-12-411545-3.00001-8
NR 230
TC 8
Z9 9
U1 7
U2 18
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2024
VL 17
BP 3329
EP 3354
DI 10.2147/JPR.S469491
PG 26
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA I8A0T
UT WOS:001332417600001
PM 39403098
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Almeida, KAM
   Rocha, AP
   Carvas, N
   Nunes, ACP Jr
AF Meireles Almeida, Kleicyane Aguiar
   Rocha, Aline Pereira
   Carvas, Nelson
   Pereira Nunes Pinto, Ana Carolina
TI Rehabilitation Interventions for Shoulder Dysfunction in Patients With
   Head and Neck Cancer: Systematic Review and Meta-Analysis
SO PHYSICAL THERAPY
LA English
DT Review
ID QUALITY-OF-LIFE; DISSECTION; DISABILITY; PAIN; IMPAIRMENT; EXERCISE;
   TRIAL; INDEX
AB Objective. Shoulder pain and dysfunction are highly prevalent after neck dissection in the treatment of head and neck cancer (HNC). They can lead to muscle weakness, limited range of motion, and shoulder tilt and pain, which can reduce patient functioning. The purpose of this study was to evaluate the effectiveness of rehabilitation interventions for shoulder dysfunction in patients with surgically treated HNC.
   Methods. A search of principal databases (MEDLINE, Embase, CENTRAL, LILACS, IBECS, PEDro, and SciELO) was conducted, in addition to hand searches and a search of gray literature, for all randomized clinical trials (RCTs) published before February 2020. Two authors independently selected all relevant studies. The 7 RCTs fulfilling all inclusion and exclusion criteria were assessed for risk of bias and certainty of evidence using the Cochrane Collaboration risk-of-bias tool and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool, respectively.
   Results. Moderate-certainty evidence suggests that progressive resistance training is better than conventional treatment for improving pain and dysfunction in patients with HNC (pooled data from 214 participants; mean difference = -5.92; 95% CI = -11.38 to -0.45). Low-certainty evidence (data from 2 RCTs with 106 participants that could not be combined) suggests that acupuncture seems to be more effective than conventional treatment.
   Conclusions. Progressive resistance training is effective for improving shoulder pain and dysfunction in patients with HNC. Further high-quality RCTs are needed to examine the effectiveness of acupuncture for improving shoulder pain and dysfunction in these patients. Future studies with longer follow-up times are needed to clarify the effects of early postoperative intervention.
   Impact. Clinicians can have confidence that progressive resistance training in patients with surgically treated HNC is effective.
   Lay Summary. These study results show that people with head and neck cancer can benefit from gradually increased resistance training to reduce shoulder pain and improve function. This study will help researchers design clinical trials to determine whether treatments such as acupuncture and early physical therapy also could be effective in treating this population.
C1 [Meireles Almeida, Kleicyane Aguiar; Pereira Nunes Pinto, Ana Carolina] Univ Fed Amapa, Biol & Hlth Sci Dept, Rod Juscelino Kubitschek,Km 02 Jardim Marco Zero, BR-68903419 Macapa, AP, Brazil.
   [Rocha, Aline Pereira] Univ Fed Sao Paulo, Discipline Emergency & Evidence Based Med, Sao Paulo, Brazil.
   [Carvas, Nelson] Inst Assistencia Med Servidor Publ Estadual, Dept Phys Educ, Sao Paulo, SP, Brazil.
   [Pereira Nunes Pinto, Ana Carolina] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
C3 Fundacao Universidade Federal do Amapa; Universidade Federal de Sao
   Paulo (UNIFESP); Instituto de Assistencia Medica ao Servidor Publico
   Estadual (IAMSPE); Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Nunes, ACP Jr (corresponding author), Univ Fed Amapa, Biol & Hlth Sci Dept, Rod Juscelino Kubitschek,Km 02 Jardim Marco Zero, BR-68903419 Macapa, AP, Brazil.; Nunes, ACP Jr (corresponding author), Univ Pittsburgh, Pittsburgh, PA 15260 USA.
EM anacarolinapnp@hotmail.com
RI Rocha, Aline/LBH-6175-2024; Pinto, Ana Carolina Pereira
   Nunes/U-6177-2017
OI Pinto, Ana Carolina Pereira Nunes/0000-0002-1505-877X
CR Breckenridge JD, 2011, J PHYSIOTHER, V57, P197, DOI 10.1016/S1836-9553(11)70045-5
   Cappiello Johnny, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P107, DOI 10.1097/MOO.0b013e3280523ac5
   Cardoso LR, 2015, HEAD NECK-J SCI SPEC, V37, P1733, DOI 10.1002/hed.23825
   Carvalho APV, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008693.pub2
   Chatterjee M, 2017, Indian Journal of Physiotherapy and Occupational Therapy - An International Journal, V11, P57, DOI [10.5958/0973-5674.2017.00012.0, DOI 10.5958/0973-5674.2017.00012.0]
   Deganello A, 2016, LARYNGOSCOPE, V126, P1790, DOI 10.1002/lary.25921
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   Fitzmaurice C, 2017, JAMA ONCOL, V3, P524, DOI [10.1001/jamaoncol.2016.5688, 10.1001/jamaoncol.2018.2706]
   GRADEpro GDT, 2015, GRADES SOFTW SUMM FI
   Guyatt GH, 2008, BMJ-BRIT MED J, V336, P995, DOI 10.1136/bmj.39490.551019.BE
   Lauchlan DT, 2008, EUR J CANCER CARE, V17, P542, DOI 10.1111/j.1365-2354.2007.00862.x
   Lauchlan DT, 2011, EUR J CANCER CARE, V20, P113, DOI 10.1111/j.1365-2354.2009.01149.x
   McGarvey AC, 2014, HEAD NECK, V37, P1022
   McNeely ML, 2008, CANCER, V113, P214, DOI 10.1002/cncr.23536
   McNeely ML, 2004, HEAD NECK-J SCI SPEC, V26, P518, DOI 10.1002/hed.20010
   Nasser Mona, 2020, AM J PUBLIC HEALTH, V110, P753, DOI [10.2105/AJPH.2020.305609, DOI 10.2105/AJPH.2020.305609]
   Patterson RH, 2020, OTOLARYNG HEAD NECK, V162, P296, DOI 10.1177/0194599819897265
   Pfister DG, 2010, J CLIN ONCOL, V28, P2565, DOI 10.1200/JCO.2009.26.9860
   Quan D., 1999, ORTHOPAEDIC J, V12, P45, DOI DOI 10.1016/B978-0-7506-1183-1.50010-3
   Schmitt JS, 2004, J CLIN EPIDEMIOL, V57, P1008, DOI 10.1016/j.jclinepi.2004.02.007
   Taylor RJ, 2002, ARCH OTOLARYNGOL, V128, P44, DOI 10.1001/archotol.128.1.44
   Veyseller B, 2010, J OTOLARYNGOL-HEAD N, V39, P403, DOI 10.2310/7070.2010.090188
   Vrotsou K, 2018, QUAL LIFE RES, V27, P2217, DOI 10.1007/s11136-018-1875-7
NR 23
TC 21
Z9 26
U1 0
U2 14
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0031-9023
EI 1538-6724
J9 PHYS THER
JI Phys. Therapy
PD NOV
PY 2020
VL 100
IS 11
BP 1997
EP 2008
DI 10.1093/ptj/pzaa147
PG 12
WC Orthopedics; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rehabilitation
GA OW8RE
UT WOS:000593146200012
PM 32750136
OA Bronze
DA 2026-01-16
ER

PT J
AU Hou, S
   Huh, B
   Kim, HK
   Kim, KH
   Abdi, S
AF Hou, Saiyun
   Huh, Billy
   Kim, Hee Kee
   Kim, Kyung-Hoon
   Abdi, Salahadin
TI Treatment of Chemotherapy-Induced Peripheral Neuropathy: Systematic
   Review and Recommendations
SO PAIN PHYSICIAN
LA English
DT Review
DE Chemotherapy-induced neuropathy; peripheral neuropathy;
   chemotherapy-tumor; neuropathic pain; chronic pain; toxicology;
   treatment; reduction of pain; level of evidence
ID EVIDENCE-BASED GUIDELINE; QUALITY-OF-LIFE; INDUCED POLYNEUROPATHY;
   DOUBLE-BLIND; SCRAMBLER THERAPY; AMERICAN ACADEMY; CONTROLLED-TRIAL;
   PILOT TRIAL; PAIN; ACUPUNCTURE
AB Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a commonly encountered disease entity following chemotherapy for cancer treatment. Although only duloxetine is recommended by the American Society of Clinical Oncology (ASCO) for the treatment of CIPN in 2014, the evidence of the clinical outcome for new pharmaceutic therapies and non-pharmaceutic treatments has not been clearly determined.
   Objective: To provide a comprehensive review and evidence-based recommendations on the treatment of CIPN.
   Study Design: A systematic review of each treatment regimen in patients with CIPN.
   Methods: The literature on the treatment of CIPN published from 1990 to 2017 was searched and reviewed. The 2011 American Academy of Neurology Clinical Practice Guidelines Process Manual was used to grade the evidence and risk of bias. We reviewed and updated the recommendations of the ASCO in 2014, and evaluated new approaches for treating CIPN.
   Results: A total of 26 treatment options in 35 studies were identified. Among these, 7 successful RCTs, 6 failed RCTs, 18 prospective studies, and 4 retrospective studies were included. The included studies examined not only pharmacologic therapy but also other modalities, including laser therapy, scrambler therapy, magnetic field therapy and acupuncture, etc. Most of the included studies had small sample sizes, and short follow-up periods. Primary outcome measures were highly variable across the included studies. No studies were prematurely closed owing to its adverse effects.
   Limitations: The limitations of this systematic review included relatively poor homogeneous, with variations in timing of treatment, primary outcomes, and chemotherapeutic agents used.
   Conclusion: The evidence is considered of moderate benefit for duloxetine. Photobiomodulation, known as low level laser therapy, is considered of moderate benefit based on the evidence review. Evidence did not support the use of lamotrigine and topical KA (4% ketamine and 2% amitriptyline). The evidence for tricyclic antidepressants was inconclusive as amitriptyline showed no benefit but nortriptyline had insufficient evidence. Further research on CIPN treatment is needed with larger sample sizes, long-term follow-up, standardized outcome measurements, and standardized treatment timing.
C1 [Hou, Saiyun; Huh, Billy; Kim, Hee Kee; Abdi, Salahadin] Univ Texas MD Anderson Canc Ctr, Dept Pain Med, 1400 Holcombe Blvd,Unit 0409, Houston, TX 77030 USA.
   [Kim, Kyung-Hoon] Pusan Natl Univ, Pusan, South Korea.
C3 University of Texas System; UTMD Anderson Cancer Center; Pusan National
   University
RP Abdi, S (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Pain Med, 1400 Holcombe Blvd,Unit 0409, Houston, TX 77030 USA.
EM sabdi@mdanderson.org
RI ; Kim, Hee/ABH-9670-2020
OI Abdi, Salahadin/0000-0002-3892-9208; 
FU Helen Buchanan and Stanley Joseph Seeger Endowment at The University of
   Texas MD Anderson Cancer Center
FX The study was sponsored by grants from Helen Buchanan and Stanley Joseph
   Seeger Endowment at The University of Texas MD Anderson Cancer Center to
   Dr. Abdi. But the manuscript is separate and apart from the guidance of
   the sponsor.
CR Addington J, 2016, F1000RES, P5
   Argenta PA, 2017, GYNECOL ONCOL, V144, P159, DOI 10.1016/j.ygyno.2016.11.013
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Barton DL, 2011, SUPPORT CARE CANCER, V19, P833, DOI 10.1007/s00520-010-0911-0
   Beijers A, 2014, J COMMUNITY SUPPORT, V12, P401, DOI 10.12788/jcso.0086
   Briani C, 2014, J PERIPHER NERV SYST, V19, P299, DOI 10.1111/jns.12097
   Bril V, 2011, NEUROLOGY, V76, P1758, DOI 10.1212/WNL.0b013e3182166ebe
   Cartoni C, 2012, SUPPORT CARE CANCER, V20, P2621, DOI 10.1007/s00520-012-1511-y
   Cavaletti G, 2013, ANN ONCOL, V24, P454, DOI 10.1093/annonc/mds329
   Cavaletti G, 2010, EUR J CANCER, V46, P479, DOI 10.1016/j.ejca.2009.12.008
   Chaudhry V, 2008, J PERIPHER NERV SYST, V13, P275, DOI 10.1111/j.1529-8027.2008.00193.x
   Cornblath DR, 1999, NEUROLOGY, V53, P1660, DOI 10.1212/WNL.53.8.1660
   Coyne Patrick J, 2013, J Pain Palliat Care Pharmacother, V27, P359, DOI 10.3109/15360288.2013.847519
   Desideri I, 2017, MED ONCOL, V34, DOI 10.1007/s12032-017-0907-4
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Fallon MT, 2015, SUPPORT CARE CANCER, V23, P2769, DOI 10.1007/s00520-015-2642-8
   Fukuda Y, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00481
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Geiger G, 2015, BIOELECTROMAGNETICS, V36, P251, DOI 10.1002/bem.21897
   Geisler S, 2016, BRAIN, V139, P3092, DOI 10.1093/brain/aww251
   Gewandter JS, 2017, NEUROLOGY, V89, P859, DOI 10.1212/WNL.0000000000004272
   Gewandter JS, 2014, SUPPORT CARE CANCER, V22, P1807, DOI 10.1007/s00520-014-2158-7
   Gornstein E, 2014, NEUROPHARMACOLOGY, V76, P175, DOI 10.1016/j.neuropharm.2013.08.016
   Gronseth G., 2019, Amendments to the 2011 American Academy of Neurology Clinical Practice Guideline Process Manual
   Gronseth GS., 2011, Clinical practice guideline process manual
   Hall KE, 2001, J NEUROPHYSIOL, V86, P760, DOI 10.1152/jn.2001.86.2.760
   Hammack JE, 2002, PAIN, V98, P195, DOI 10.1016/S0304-3959(02)00047-7
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Hirayama Y, 2015, INT J CLIN ONCOL, V20, P866, DOI 10.1007/s10147-015-0810-y
   Hou SY, 2016, NEUROMODULATION, V19, P398, DOI 10.1111/ner.12440
   Hsieh YL, 2016, ACUPUNCT MED, V34, P398, DOI 10.1136/acupmed-2016-011112
   Johnstone TC, 2014, ANTICANCER RES, V34, P471
   Jordan MA, 2004, NAT REV CANCER, V4, P253, DOI 10.1038/nrc1317
   Kautio AL, 2008, J PAIN SYMPTOM MANAG, V35, P31, DOI 10.1016/j.jpainsymman.2007.02.043
   Kerckhove N, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00086
   Kirchmair R, 2007, MOL THER, V15, P69, DOI 10.1038/sj.mt.6300019
   Kus T, 2016, SUPPORT CARE CANCER, V24, P2085, DOI 10.1007/s00520-015-3009-x
   Lindblad K, 2016, SUPPORT CARE CANCER, V24, P2523, DOI 10.1007/s00520-015-3060-7
   Loprinzi CL, 2011, J CLIN ONCOL, V29, P1472, DOI 10.1200/JCO.2010.33.0308
   Lynch ME, 2014, J PAIN SYMPTOM MANAG, V47, P166, DOI 10.1016/j.jpainsymman.2013.02.018
   Maestri A, 2005, TUMORI J, V91, P135, DOI 10.1177/030089160509100206
   McCrary JM, 2017, SUPPORT CARE CANCER, V25, P3485, DOI 10.1007/s00520-017-3772-y
   Miltenburg NC, 2014, CANCER TREAT REV, V40, P872, DOI 10.1016/j.ctrv.2014.04.004
   Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
   Otake A, 2015, ANTICANCER RES, V35, P359
   Pachman DR, 2015, SUPPORT CARE CANCER, V23, P943, DOI 10.1007/s00520-014-2424-8
   Piccolo J, 2014, AM J HEALTH-SYST PH, V71, P19, DOI 10.2146/ajhp130126
   Prinsloo S, 2017, CANCER-AM CANCER SOC, V123, P1989, DOI 10.1002/cncr.30649
   Rao RD, 2008, CANCER, V112, P2802, DOI 10.1002/cncr.23482
   Rao RD, 2007, CANCER-AM CANCER SOC, V110, P2110, DOI 10.1002/cncr.23008
   Rick O, 2017, BIOELECTROMAGNETICS, V38, P85, DOI 10.1002/bem.22005
   Sacco J, 2016, MED ACUPUNCT, V28, P131, DOI 10.1089/acu.2016.1170
   Schellinger PD, 2010, NEUROLOGY, V75, P177, DOI 10.1212/WNL.0b013e3181e7c9dd
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Simpson DM, 2016, NEUROLOGY, V86, P1818, DOI 10.1212/WNL.0000000000002560
   Sittl R, 2012, P NATL ACAD SCI USA, V109, P6704, DOI 10.1073/pnas.1118058109
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Smith EML, 2010, CANCER NURS, V33, P173, DOI 10.1097/NCC.0b013e3181c989a3
   Smith TJ, 2010, J PAIN SYMPTOM MANAG, V40, P883, DOI 10.1016/j.jpainsymman.2010.03.022
   Staff NP, 2017, ANN NEUROL, V81, P772, DOI 10.1002/ana.24951
   Truini A, 2011, CNS NEUROL DISORD-DR, V10, P916, DOI 10.2174/187152711799219307
   Tsavaris N, 2008, PAIN MED, V9, P1209, DOI 10.1111/j.1526-4637.2007.00325.x
   van den Heuvel SAS, 2017, PAIN RES MANAG, V2017, DOI 10.1155/2017/8053474
   Verma V, 2014, CURR NEUROPHARMACOL, V12, P44, DOI 10.2174/1570159X1201140117162802
   Wong R, 2016, INTEGR CANCER THER, V15, P153, DOI 10.1177/1534735415627926
   Yang YH, 2012, SUPPORT CARE CANCER, V20, P1491, DOI 10.1007/s00520-011-1237-2
   Yoon J, 2012, J ACUPUNCT MERIDIAN, V5, P156, DOI [10.1016/j.jams.2012.05.003, 10.106/j.jams.2012.05.003]
   Ziegler D, 2014, J DIABETES COMPLICAT, V28, P698, DOI 10.1016/j.jdiacomp.2014.04.004
   Zilliox L, 2011, CURR TREAT OPTION NE, V13, P143, DOI 10.1007/s11940-011-0113-1
NR 70
TC 103
Z9 122
U1 0
U2 19
PU AM SOC INTERVENTIONAL PAIN PHYSICIANS
PI PADUCAH
PA 81 LAKEVIEW DR, PADUCAH, KY 42001 USA
SN 1533-3159
J9 PAIN PHYSICIAN
JI Pain Physician
PD NOV-DEC
PY 2018
VL 21
IS 6
BP 571
EP 592
PG 22
WC Anesthesiology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA HC2OC
UT WOS:000451640600015
PM 30508986
OA Bronze
DA 2026-01-16
ER

PT J
AU Lu, ZH
   Luo, AL
   Min, S
   Dong, HL
   Xiong, QJ
   Li, XH
   Deng, QZ
   Liu, TT
   Yang, X
   Li, C
   Zhao, QC
   Xiong, LZ
AF Lu, Zhihong
   Luo, Ailin
   Min, Su
   Dong, Hailong
   Xiong, Qiuju
   Li, Xinhua
   Deng, Qingzhu
   Liu, Tingting
   Yang, Xue
   Li, Chen
   Zhao, Qingchuan
   Xiong, Lize
TI Acupoint Stimulation for Enhanced Recovery After Colon Surgery: A
   Prospective Multicenter Randomized Controlled Trial
SO JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
LA English
DT Article
DE transcutaneous electrical acupoint stimulation; colon surgery;
   laparoscopy; ERAS
ID IMPROVE POSTOPERATIVE RECOVERY; COLORECTAL SURGERY; CANCER PATIENTS;
   GASTRIC-CANCER; ELECTROACUPUNCTURE; ACUPUNCTURE; QUALITY; METAANALYSIS;
   PATHWAY; ILEUS
AB Purpose: The aim of this study was to evaluate the efficacy of transcutaneous electrical acupoint stimulation (TEAS) in improving bowel function and thus shortening hospital stay after laparoscopic colon surgery within the ERAS pathway.Patients and Methods: From November 2016 to March 2018, 100 patients who underwent elective colon surgery were enrolled and 94 finished study (n = 47 for each) in three university hospitals. Patients in the TEAS group received TEAS 30 min before surgery and once a day for 3 days after surgery, while those in the Control Group received no stimulation. Primary outcome was the time to discharge. Results: Compared with standardized postoperative care, TEAS resulted in a shorter time to first flatus (P=0.03) and time to first defecation (P=0.03), as well as a reduction in the length of hospital stay (P=0.02). Median patient-controlled analgesia (PCA) deliveries and PCA attempts at 24h, 48h and 72h after surgery were less in the TEAS group (P<0.01). No evidence of significant advantages in postoperative pain intensity, nausea, vomiting, sleeping quality and expenses was found in the TEAS group.Conclusion: Perioperative TEAS further shortens the time to meet discharge criteria after laparoscopic colon surgery in patients under ERAS strategy.
C1 [Lu, Zhihong; Dong, Hailong; Liu, Tingting; Yang, Xue; Xiong, Lize] Fourth Mil Med Univ, Xijing Hosp, Dept Anaesthesiol & Perioperat Med, Xian, Peoples R China.
   [Luo, Ailin; Li, Xinhua; Deng, Qingzhu] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Anaesthesiol, Wuhan, Peoples R China.
   [Min, Su; Xiong, Qiuju] Chongqing Med Univ, Affiliated Hosp 5, Dept Anaesthesiol, Chongqing, Peoples R China.
   [Li, Chen] Fourth Mil Med Univ, Dept Med Stat, Xian, Peoples R China.
   [Zhao, Qingchuan] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian, Peoples R China.
   [Xiong, Lize] Tongji Univ Sch Med, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Like Intelligence, Dept Anesthesiol, Shanghai, Peoples R China.
   [Lu, Zhihong; Xiong, Lize] Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol & Perioperat Med, Changle West Road127, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Huazhong University of Science &
   Technology; Chongqing Medical University; Air Force Medical University;
   Air Force Medical University; Tongji University; Air Force Medical
   University
RP Lu, ZH; Xiong, LZ (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol & Perioperat Med, Changle West Road127, Xian 710032, Shaanxi, Peoples R China.
EM deerlu23@163.com; xlzmzk@163.com
RI ; Liu, Tingting/S-3995-2016
OI lu, zhihong/0000-0001-5639-4705; Luo, Ailin/0000-0001-8826-5588
FU National Key Basic Research Program of China [2014CB543200]; National
   Natural Science Foundation of China [81871028]; National Cultivation and
   Development Program [2021ZY019]; Aeromedical Flow Principal Investigator
   Program of Air Force Medical University [2022HYPI02]
FX This work was supported by the National Key Basic Research Program of
   China (No. 2014CB543200), the National Natural Science Foundation of
   China (No. 81871028), the National Cultivation and Development Program
   (2021ZY019) and the Aeromedical Flow Principal Investigator Program of
   Air Force Medical University (2022HYPI02) .
CR Ban KA, 2019, CLIN COLON RECT SURG, V32, P109, DOI 10.1055/s-0038-1676475
   De Giorgio R, 2021, ADV THER, V38, P3589, DOI 10.1007/s12325-021-01766-y
   Farmer AD, 2018, LANCET GASTROENTEROL, V3, P203, DOI 10.1016/S2468-1253(18)30008-6
   Feng F, 2014, J DIGEST DIS, V15, P306, DOI 10.1111/1751-2980.12142
   Feng F, 2013, WORLD J GASTROENTERO, V19, P3642, DOI 10.3748/wjg.v19.i23.3642
   Guillou PJ, 2005, LANCET, V365, P1718, DOI 10.1016/S0140-6736(05)66545-2
   Huang ZX, 2022, WORLD J SURG ONCOL, V20, DOI 10.1186/s12957-022-02796-8
   Gül DK, 2021, J OBSTET GYNAECOL, V41, P573, DOI 10.1080/01443615.2020.1787363
   Lassen K, 2009, ARCH SURG-CHICAGO, V144, P961, DOI 10.1001/archsurg.2009.170
   Lee HY, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2243-4
   Li WJ, 2021, J INTEGR MED-JIM, V19, P211, DOI 10.1016/j.joim.2021.01.005
   Liu YH, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/2504021
   Lu Z, 2015, BRIT J ANAESTH, V115, P183, DOI 10.1093/bja/aev227
   Luo D, 2008, DIGEST DIS SCI, V53, P689, DOI 10.1007/s10620-007-9929-7
   Menear A, 2017, NURS CRIT CARE, V22, P348, DOI 10.1111/nicc.12315
   Meng ZQ, 2010, WORLD J GASTROENTERO, V16, P104, DOI 10.3748/wjg.v16.i1.104
   Ng SSM, 2013, GASTROENTEROLOGY, V144, P307, DOI 10.1053/j.gastro.2012.10.050
   Ni XF, 2019, J GASTROINTEST SURG, V23, P1502, DOI 10.1007/s11605-019-04170-8
   Ota H, 2017, SURG TODAY, V47, P668, DOI 10.1007/s00595-016-1423-4
   Ripollés-Melchor J, 2019, JAMA SURG, V154, P725, DOI 10.1001/jamasurg.2019.0995
   Santucci NR, 2021, COMPLEMENT THER MED, V59, DOI 10.1016/j.ctim.2021.102711
   Sheng RY, 2021, WORLD J TRAD CHINESE, V7, P397, DOI 10.4103/wjtcm.wjtcm_27_21
   Smith TW, 2020, AM J SURG, V219, P530, DOI 10.1016/j.amjsurg.2019.11.009
   Sommer NP, 2021, INT J COLORECTAL DIS, V36, P2017, DOI 10.1007/s00384-021-03939-1
   Soylu D, 2021, COMPLEMENT THER CLIN, V43, DOI 10.1016/j.ctcp.2021.101304
   Stark PA, 2013, ANESTHESIOLOGY, V118, P1332, DOI 10.1097/ALN.0b013e318289b84b
   Thillainadesan J, 2021, DIS COLON RECTUM, V64, P1020, DOI 10.1097/DCR.0000000000002128
   Wang H, 2014, BRIT J ANAESTH, V112, P1075, DOI 10.1093/bja/aeu001
   Wang XY, 2021, J GASTROEN HEPATOL, V36, P3015, DOI 10.1111/jgh.15645
   Wang Y, 2023, JAMA SURG, V158, P20, DOI 10.1001/jamasurg.2022.5674
   Yang NN, 2021, THERANOSTICS, V11, P4078, DOI 10.7150/thno.52574
   Yang NN, 2020, NEUROGASTROENT MOTIL, V32, DOI 10.1111/nmo.13808
   Zhang ZD, 2014, ACUPUNCT MED, V32, P223, DOI 10.1136/acupmed-2013-010490
   Zhou X, 2021, CANCER MANAG RES, V13, P1449, DOI 10.2147/CMAR.S292325
   Zhu YJ, 2022, J PAIN SYMPTOM MANAG, V63, P210, DOI 10.1016/j.jpainsymman.2021.09.009
NR 35
TC 4
Z9 7
U1 3
U2 33
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2390
J9 J MULTIDISCIP HEALTH
JI J. Multidiscip. Healthc.
PY 2022
VL 15
BP 2871
EP 2879
DI 10.2147/JMDH.S391852
PG 9
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 7F7QT
UT WOS:000902038100001
PM 36570812
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Bonucci, M
   Geraci, A
   Pero, D
   Villivà, C
   Cordella, D
   Condello, M
   Meschini, S
   Del Campo, L
   Tomassi, F
   Porcu, A
   De Lorenzo, F
   Lozupone, F
AF Bonucci, Massimo
   Geraci, Andrea
   Pero, Dina
   Villiva, Cristina
   Cordella, Daniele
   Condello, Maria
   Meschini, Stefania
   Del Campo, Laura
   Tomassi, Franco
   Porcu, Alessandro
   De Lorenzo, Francesco
   Lozupone, Francesco
TI Complementary and Integrative Approaches to Cancer: A Pilot Survey of
   Attitudes and Habits among Cancer Patients in Italy
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID HEXOSE-CORRELATED COMPOUND; ALTERNATIVE MEDICINE USE; DRUG-INTERACTIONS;
   BREAST-CANCER; FOLLOW-UP; CAM USE; CHEMOTHERAPY; PREVALENCE; EXTRACT;
   WOMEN
AB Background. Cancer patients are among the main consumers of traditional, complementary, integrative, and alternative medicine (TCIM) such as natural products (herbals, integrators, etc.) and mind and body practices (yoga, acupuncture, etc.). Methods. A questionnaire on TCIM was submitted to 415 Italian cancer patients. The questionnaire consisted of three sections: (i) biographical and clinical information; (ii) use of natural substances; and (iii) use of mind-body practices. Results. 406 patients completed the questionnaire. The prevalence of TCIM use was 72.3%. Of them, 75.6% started to use TCIM after a tumor diagnosis. The main reasons for using TCIM were to mitigate side effects (65.0%), to regain physical and mental balance (35.9%), to relieve pain (18.3%), and to improve the efficacy of cancer therapy (16.0%). 44.7% of patients taking natural products used them during conventional therapies (chemotherapy, radiotherapy, etc.), and in 67.5% of cases without consulting a doctor. As a consequence, only about 50% of patients taking natural substances used these compounds appropriately, and the most common errors were related with the purpose of reducing the side effects of the therapy (52.3%) and for boosting immune system (32.1%). Conclusions. There is an impelling need to provide patients with scientifically validated information to raise awareness about the benefits and risks of using TCIM.
C1 [Bonucci, Massimo; Villiva, Cristina; Tomassi, Franco] Assoc Res Integrat Oncol Therapies ARTOI, Rome, Italy.
   [Geraci, Andrea; Lozupone, Francesco] Ist Super Sanita, Italian Ctr Global Hlth, Rome, Italy.
   [Pero, Dina; Del Campo, Laura; Porcu, Alessandro; De Lorenzo, Francesco] Italian Assoc Canc Patients, Relat & Friends AIMaC, Rome, Italy.
   [Cordella, Daniele] Ist Super Sanita, Directorate Gen Informat Technol Unit, Rome, Italy.
   [Condello, Maria; Meschini, Stefania] Ist Super Sanita, Natl Ctr Drug Res & Evaluat, Rome, Italy.
C3 Istituto Superiore di Sanita (ISS); Istituto Superiore di Sanita (ISS);
   Istituto Superiore di Sanita (ISS)
RP Lozupone, F (corresponding author), Ist Super Sanita, Italian Ctr Global Hlth, Rome, Italy.
EM francesco.lozupone@iss.it
RI ; Lozupone, Francesco/H-2998-2016; BONUCCI, MASSIMO/AAB-2386-2020;
   Condello, Maria/E-9095-2015; Geraci, Anea/IWM-5286-2023; MESCHINI,
   STEFANIA/E-9091-2015
OI Cordella, Daniele/0009-0004-7182-1786; Lozupone,
   Francesco/0000-0002-4959-9400; BONUCCI, MASSIMO/0000-0002-8245-8642;
   Condello, Maria/0000-0002-2802-9142; Geraci, Anea/0000-0002-0174-228X;
   MESCHINI, STEFANIA/0000-0001-9079-1181
CR Agaguenduez D, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/1534083
   Akkol EK, 2021, CANCERS, V13, DOI 10.3390/cancers13112733
   Arthur K, 2012, INTEGR CANCER THER, V11, P232, DOI 10.1177/1534735411433832
   Behzadmehr R, 2020, COMPLEMENT THER MED, V49, DOI 10.1016/j.ctim.2020.102318
   Bernstein BJ, 2001, ONCOLOGY-NY, V15, P1267
   Berretta M, 2017, ONCOTARGET, V8, P24401, DOI 10.18632/oncotarget.14224
   Buckner CA, 2018, CURR ONCOL, V25, pE275, DOI 10.3747/co.25.3884
   Carlo P, 2011, CANCER FORUM, V35, P21
   Chetan CA, 2010, J ADV PHARM TECHNOL, V1, P245
   Clairet AL, 2019, MED ONCOL, V36, DOI 10.1007/s12032-019-1267-z
   Dufter SA, 2021, J CANCER RES CLIN, V147, P3685, DOI 10.1007/s00432-021-03605-7
   Eldahshan OA, 2015, CYTOTECHNOLOGY, V67, P831, DOI 10.1007/s10616-014-9723-2
   Engdal S, 2009, PHYTOTHER RES, V23, P906, DOI 10.1002/ptr.2750
   Falzone L, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01300
   Fernández J, 2021, BIOMED PHARMACOTHER, V143, DOI 10.1016/j.biopha.2021.112241
   Fitzmaurice C, 2019, JAMA ONCOL, V5, P1749, DOI 10.1001/jamaoncol.2019.2996
   Gao Q, 2011, ACTA PHARM SIN B, V1, P121, DOI 10.1016/j.apsb.2011.06.009
   Haefeli WE, 2014, EXPERT OPIN DRUG MET, V10, P359, DOI 10.1517/17425255.2014.873786
   Hangai S, 2013, J ALTERN COMPLEM MED, V19, P905, DOI 10.1089/acm.2012.0914
   Harris PE, 2012, INT J CLIN PRACT, V66, P924, DOI 10.1111/j.1742-1241.2012.02945.x
   Hassett MJ, 2006, JNCI-J NATL CANCER I, V98, P1108, DOI 10.1093/jnci/djj305
   Horneber M, 2012, INTEGR CANCER THER, V11, P187, DOI 10.1177/1534735411423920
   Islam MR, 2022, MOLECULES, V27, DOI 10.3390/molecules27072165
   Ito T, 2014, NUTR CANCER, V66, P377, DOI 10.1080/01635581.2014.884232
   Kemppainen LM, 2018, SCAND J PUBLIC HEALT, V46, P448, DOI 10.1177/1403494817733869
   Lin SR, 2020, BRIT J PHARMACOL, V177, P1409, DOI 10.1111/bph.14816
   Mathew L, 2017, INTEGR CANCER THER, V16, P300, DOI 10.1177/1534735417704948
   Mclay JS, 2012, EUR J CLIN PHARMACOL, V68, P811, DOI 10.1007/s00228-011-1181-6
   Meijerman I, 2006, ONCOLOGIST, V11, P742, DOI 10.1634/theoncologist.11-7-742
   Mitra S, 2022, CANCERS, V14, DOI 10.3390/cancers14030759
   Murray SA, 2005, BMJ-BRIT MED J, V330, P1007, DOI 10.1136/bmj.330.7498.1007
   Pearce A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184360
   Pihlak R, 2014, EUR J CANCER CARE, V23, P249, DOI 10.1111/ecc.12132
   Posadzki P, 2013, BRIT J CLIN PHARMACO, V75, P603, DOI 10.1111/j.1365-2125.2012.04350.x
   Richardson MA, 2000, J CLIN ONCOL, V18, P2505, DOI 10.1200/JCO.2000.18.13.2505
   Sauter ER, 2020, EXPERT REV CLIN PHAR, V13, P265, DOI 10.1080/17512433.2020.1738218
   Schink M, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-2028-1
   Scott J A, 2005, Eur J Oncol Nurs, V9, P131, DOI 10.1016/j.ejon.2005.03.012
   Semiglazov VF, 2006, ANTICANCER RES, V26, P1519
   Silva JD, 2020, J TOXICOL ENV HEAL A, V83, P525, DOI 10.1080/15287394.2020.1780658
   Stie M, 2022, CANCERS, V14, DOI 10.3390/cancers14040952
   Suenaga S, 2014, ANTICANCER RES, V34, P141
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Tröger W, 2012, BREAST CANCER-BASIC, V6, P173, DOI 10.4137/BCBCR.S10558
   Vapiwala N, 2006, CANCER J, V12, P467, DOI 10.1097/00130404-200611000-00006
   Verhoef MJ, 2009, CHRONIC DIS CAN, V29, P80
   Wanwimolruk S, 2014, EXCLI J, V13, P347
   Weissenstein U, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-6
   Werthmann PG, 2018, HEAD NECK-J SCI SPEC, V40, pE77, DOI 10.1002/hed.25320
   Wode K, 2019, BMC COMPLEM ALTERN M, V19, DOI 10.1186/s12906-019-2452-5
   Xing Pan-pan, 2011, Yao Xue Xue Bao, V46, P573
   Yates JS, 2005, SUPPORT CARE CANCER, V13, P806, DOI 10.1007/s00520-004-0770-7
   US
NR 53
TC 9
Z9 10
U1 2
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD AUG 5
PY 2022
VL 2022
AR 2923967
DI 10.1155/2022/2923967
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 3Z7XB
UT WOS:000844628800025
PM 35958921
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Gorski, DH
AF Gorski, David H.
TI Author reply: the role of academic health centres to inform
   evidence-based integrative oncology practice
SO NATURE REVIEWS CANCER
LA English
DT Letter
ID ACUPUNCTURE; PAIN
C1 [Gorski, David H.] Wayne State Univ, Sch Med, Dept Surg, Michael & Marian Ilitch,Univ Hlth Ctr 6C, Detroit, MI 48201 USA.
   [Gorski, David H.] Barbara Ann Karmanos Canc Inst, Mol Therapeut Program, Detroit, MI 48201 USA.
   [Gorski, David H.] Barbara Ann Karmanos Canc Inst, Dept Oncol, Detroit, MI 48201 USA.
C3 Wayne State University; Barbara Ann Karmanos Cancer Institute; Barbara
   Ann Karmanos Cancer Institute
RP Gorski, DH (corresponding author), Wayne State Univ, Sch Med, Dept Surg, Michael & Marian Ilitch,Univ Hlth Ctr 6C, 4201 St Antoine St, Detroit, MI 48201 USA.
EM gorskid@med.wayne.edu
RI Gorski, David/AAE-6399-2022
OI Gorski, David/0000-0002-9805-6699
CR Colquhoun D, 2013, ANESTH ANALG, V116, P1360, DOI 10.1213/ANE.0b013e31828f2d5e
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Gorski DH, 2014, NAT REV CANCER, V14, P692, DOI 10.1038/nrc3822
   Mao J. J., 2015, NATURE REV CANC
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   Newport F., 2012, Gallup Politics
   Shen YH, 2015, CANCER-AM CANCER SOC, V121, P84, DOI 10.1002/cncr.28973
   Stauffer ME, 2011, INT J INFLAMM, V2011, DOI 10.4061/2011/231926
   Tubach F, 2012, ARTHRIT CARE RES, V64, P1699, DOI 10.1002/acr.21747
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
NR 10
TC 0
Z9 0
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1474-175X
EI 1474-1768
J9 NAT REV CANCER
JI Nat. Rev. Cancer
PD APR
PY 2015
VL 15
IS 4
DI 10.1038/nrc3822-c4
PG 1
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA CE3WI
UT WOS:000351760300012
PM 25801621
DA 2026-01-16
ER

PT J
AU Enblom, A
   Johnsson, A
   Hammar, M
   Steineck, G
   Börjeson, S
AF Enblom, Anna
   Johnsson, Anna
   Hammar, Mats
   Steineck, Gunnar
   Borjeson, Sussanne
TI The Nonpenetrating Telescopic Sham Needle May Blind Patients with
   Different Characteristics and Experiences When Treated by Several
   Therapists
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID TRIAL COMPARING ACUPUNCTURE; RANDOMIZED CLINICAL-TRIALS; PLACEBO NEEDLE;
   SINGLE-BLIND; RADIOTHERAPY; STIMULATION; SENSATION; REAL; PAIN
AB Background. Little is known which factors influence the blinding in acupuncture studies. Aim. To investigate if blinding varied between patients with different characteristics receiving verum or sham acupuncture. Methods. We randomised cancer patients to verum (n = 109) or sham acupuncture (n = 106) with a nonpenetrating telescopic sham needle for nausea. Level of blinding was compared between different sub-groups of patients using Bang's blinding index (BI) ranged -1 to 1 (-1 = all state the opposite treatment, 1 = all identify treatment). Results. Most patients in the verum (74 of 95; 78%, BI 0.72) and the sham (68 of 95; 72%, BI -0.60). acupuncture group believed they had received verum acupuncture. The probability for a patient to believe he/she received verum acupuncture was related to the received needling type (P = .003) and to the patient's belief in received treatment effects (P = .008). Hospital (P = .425), therapist (P = .434), previous acupuncture experience (P = .578), occurrence of nausea (P = .157), gender (P = .760), and age (P = .357) did not affect blinding. Conclusions. Blinding was successfully achieved irrespective of age, gender, acupuncture experience, treatment effect, or in which hospital or by which therapist the patient received treatment. Patients with higher belief in the effect of the treatment were more likely to believe they had received verum acupuncture.
C1 [Enblom, Anna] Linkoping Univ, Dept Med & Hlth Sci, Div Nursing Sci, S-58185 Linkoping, Sweden.
   [Enblom, Anna] Lund Univ, Swedish Inst Hlth Sci, Vardal Inst, S-22100 Lund, Sweden.
   [Enblom, Anna] Karolinska Inst, Osher Ctr, Dept Clin Neurosci, S-17177 Stockholm, Sweden.
   [Johnsson, Anna] Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden.
   [Johnsson, Anna] Linkoping Univ, Dept Clin & Expt Med, S-58185 Linkoping, Sweden.
   [Steineck, Gunnar] Karolinska Inst, Dept Oncol Pathol, Div Clin Canc Epidemiol, S-17177 Stockholm, Sweden.
   [Steineck, Gunnar] Sahlgrens Acad, Dept Oncol, Div Clin Canc Epidemiol, S-51345 Gothenburg, Sweden.
   [Borjeson, Sussanne] Linkoping Univ Hosp, Dept Oncol, Ctr Surg Orthoped & Oncol, S-58185 Linkoping, Sweden.
C3 Linkoping University; Lund University; Karolinska Institutet; Lund
   University; Skane University Hospital; Linkoping University; Karolinska
   Institutet; University of Gothenburg; Linkoping University
RP Enblom, A (corresponding author), Linkoping Univ, Dept Med & Hlth Sci, Div Nursing Sci, S-58185 Linkoping, Sweden.
EM anna.enblom@ki.se
RI ; Hammar, Mats/R-7908-2019; Steineck, Gunnar/W-1515-2019
OI Börjeson, Sussanne/0000-0002-9786-7326; Johnsson,
   Anna/0000-0001-9347-5336; Steineck, Gunnar/0000-0002-0787-3969
FU Swedish Cancer Society; Vardal Institute; County Council of
   Ostergotland; University of Linkoping; Cancer & Traffic Injury Fund;
   Vardal Foundation-for Health Care Sciences and Allergy Research; Ostgota
   Cancer Fund; Osher Center of Karolinska Institute
FX The authors thank the patients participating in this study, Boel
   Lindberg and Ingrid Tillgren for coordinating, Eva Ahlner, Marianne
   Frid, Lotta Robert, Clary Skoglund and Annica Tomasson for treatments,
   and Tommy Nyberg for statistical support. This study was supported by
   The Swedish Cancer Society, The Vardal Institute, The County Council of
   Ostergotland, The University of Linkoping, Cancer & Traffic Injury Fund,
   The Vardal Foundation-for Health Care Sciences and Allergy Research, the
   Ostgota Cancer Fund, and the Osher Center of Karolinska Institute.
CR Anna E, 2008, COMPLEMENT THER MED, V16, P288, DOI 10.1016/j.ctim.2008.02.012
   Bang HJ, 2004, CONTROL CLIN TRIALS, V25, P143, DOI 10.1016/j.cct.2003.10.016
   Borjeson S, 2007, EJC SUPPL, V5, P142, DOI 10.1016/S1359-6349(07)70622-5
   Cherkin DC, 2009, ARCH INTERN MED, V169, P858, DOI 10.1001/archinternmed.2009.65
   Desbiens NA, 2002, MED HYPOTHESES, V59, P227, DOI 10.1016/S0306-9877(02)00205-0
   Dincer F, 2003, COMPLEMENT THER MED, V11, P235, DOI 10.1016/S0965-2299(03)00124-9
   Elden H, 2008, BJOG-INT J OBSTET GY, V115, P1655, DOI 10.1111/j.1471-0528.2008.01904.x
   Enblom A, 2011, ACUPUNCT MED, V29, P94, DOI 10.1136/aim.2010.003384
   Ernst E, 2009, J PAIN SYMPTOM MANAG, V37, P709, DOI 10.1016/j.jpainsymman.2008.04.009
   Ezzo JM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002285.pub2
   Kaptchuk TJ, 2008, BMJ-BRIT MED J, V336, P999, DOI 10.1136/bmj.39524.439618.25
   Kolahi J, 2009, COMMUNITY DENT ORAL, V37, P477, DOI 10.1111/j.1600-0528.2009.00494.x
   Kou W, 2007, AM J CHINESE MED, V35, P753, DOI 10.1142/S0192415X07005247
   Lai XS, 2009, NEUROSCI LETT, V452, P194, DOI 10.1016/j.neulet.2009.01.052
   Lee MS, 2009, EVID-BASED COMPL ALT, V6, P59, DOI 10.1093/ecam/nep085
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Manheimer E, 2006, J CLIN EPIDEMIOL, V59, P107, DOI 10.1016/j.jclinepi.2005.06.003
   McManus Claire A, 2007, Acupunct Med, V25, P36
   Moffet HH, 2008, J CLIN EPIDEMIOL, V61, P741, DOI 10.1016/j.jclinepi.2008.02.013
   Pariente J, 2005, NEUROIMAGE, V25, P1161, DOI 10.1016/j.neuroimage.2005.01.016
   Park H, 2002, AM J CHINESE MED, V30, P45, DOI 10.1142/S0192415X02000053
   Park J, 2005, ARCH INTERN MED, V165, P2026, DOI 10.1001/archinte.165.17.2026
   Park J., 1999, ACUPUNCT MED, V17, P110
   Park Jongbae, 2002, Acupunct Med, V20, P168
   Sandberg M, 2004, EUR J PAIN, V8, P163, DOI 10.1016/S1090-3801(03)00090-9
   So EWS, 2009, HUM REPROD, V24, P341, DOI 10.1093/humrep/den380
   Streitberger K, 1998, LANCET, V352, P364, DOI 10.1016/S0140-6736(97)10471-8
   Takakura Nobuari, 2007, BMC Complement Altern Med, V7, P31, DOI 10.1186/1472-6882-7-31
   Tan CW, 2009, ARCH PHYS MED REHAB, V90, P2141, DOI 10.1016/j.apmr.2009.08.142
   Tough EA, 2009, ACUPUNCT MED, V27, P118, DOI 10.1136/aim.2009.000737
   Trinh K V., 2003, Clinical Acupuncture and Oriental Medicine, V4, P71, DOI [10.1016/s1461-1449(03)00026-4, DOI 10.1016/S1461-1449(03)00026-4]
   Tsukayama H, 2006, CLIN J PAIN, V22, P346, DOI 10.1097/01.ajp.0000176359.94644.mL
   White AR, 2001, COMPLEMENT THER MED, V9, P237, DOI 10.1054/ctim.2001.0489
   White P, 2003, PAIN, V106, P401, DOI 10.1016/j.pain.2003.08.013
   Yoo SS, 2004, NEUROIMAGE, V22, P932, DOI 10.1016/j.neuroimage.2004.02.017
NR 35
TC 6
Z9 7
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2011
VL 2011
BP 1
EP 12
DI 10.1155/2011/185034
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 800UJ
UT WOS:000293392700001
PM 21747890
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Li, HJ
   Darby, JE
   Akpotu, I
   Schlaeger, JM
   Patil, CL
   Danciu, O
   Boyd, AD
   Burke, L
   Ezenwa, MO
   Knisely, MR
   Lee, TY
   Mandernach, MW
   de Martelly, VA
   Molokie, RE
   Shah, NR
   Wilkie, DJ
   Doorenbos, AZ
AF Li, Hongjin
   Darby, Juanita E.
   Akpotu, Ivy
   Schlaeger, Judith M.
   Patil, Crystal L.
   Danciu, Oana
   Boyd, Andrew D.
   Burke, Larisa
   Ezenwa, Miriam O.
   Knisely, Mitchell R.
   Lee, Ta-Ya
   Mandernach, Molly W.
   de Martelly, Victoria A.
   Molokie, Robert E.
   Shah, Nirmish
   Wilkie, Diana J.
   Doorenbos, Ardith Z.
TI Barriers and Facilitators to Integrating Acupuncture into the US Health
   Care System: A Scoping Review
SO JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review; Early Access
DE acupuncture; barriers; facilitators; implementation; integration; review
ID BREAST-CANCER SURVIVORS; MEDICINE; PATIENT; PAIN
AB Background: Acupuncture is a widely practiced complementary and integrative health modality that has multiple clinical applications. The use of acupuncture in the United States is rapidly increasing. Although studies have shown the efficacy and effectiveness of acupuncture for various ailments, the integration of acupuncture into the U.S. health care system remains a challenge. Little is known about the factors affecting this integration.Objective: To provide a systematic review of the barriers and facilitators affecting the integration of acupuncture into the U.S. health care system.Methods: Four electronic databases were searched. Three independent reviewers were involved in the screening and data charting processes. Findings were synthesized and categorized into four levels based on the Social Ecological Model.Results: A total of 22 studies were included in the final review. The barriers and facilitators affecting the integration of acupuncture were mapped into four levels (individual, interpersonal, organizational, and policy). The most frequently reported barriers and facilitators were mapped into the Social Ecological Model constructs within the "Individual" level (i.e., beliefs and attitudes of acupuncture, and practical issues) and the "Organizational" level (i.e., credentialing, space and facility, referral system).Conclusion: This review has identified and synthesized the breadth of evidence on the barriers and facilitators to the integration of acupuncture into the U.S. health care system. Results of this review will guide future implementation studies to develop and test implementation strategies to integrate acupuncture into the U.S. health care system.
C1 [Li, Hongjin; Darby, Juanita E.; Akpotu, Ivy; Schlaeger, Judith M.; Burke, Larisa; de Martelly, Victoria A.; Doorenbos, Ardith Z.] Univ Illinois, Coll Nursing, 845 S Damen Ave, Chicago, IL 60607 USA.
   [Li, Hongjin; Danciu, Oana; Doorenbos, Ardith Z.] Univ Illinois, Canc Ctr, Chicago, IL USA.
   [Patil, Crystal L.] Univ Michigan, Sch Nursing, Ann Arbor, MI USA.
   [Boyd, Andrew D.] Univ Illinois, Coll Appl Hlth Sci, Chicago, IL USA.
   [Ezenwa, Miriam O.; Wilkie, Diana J.] Univ Florida, Coll Nursing, Gainesville, FL USA.
   [Knisely, Mitchell R.] Duke Univ, Sch Nursing, Durham, NC USA.
   [Lee, Ta-Ya] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA.
   [Mandernach, Molly W.] Univ Florida, Sch Nursing, Gainesville, FL USA.
   [Molokie, Robert E.] Jesse Brown VA Med Ctr, Chicago, IL USA.
   [Shah, Nirmish] Duke Univ, Dept Med, Durham, NC USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Michigan System; University of Michigan; University of
   Illinois System; University of Illinois Chicago; University of Illinois
   Chicago Hospital; State University System of Florida; University of
   Florida; Duke University; Johns Hopkins University; Johns Hopkins
   Medicine; State University System of Florida; University of Florida; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Jesse Brown VA Medical Center; Duke University
RP Li, HJ (corresponding author), Univ Illinois, Coll Nursing, 845 S Damen Ave, Chicago, IL 60607 USA.
EM hongjin@uic.edu
RI Wilkie, Diana/ABG-5417-2021; schlaeger, judith/N-4482-2017; Patil,
   Crystal/H-7509-2016; Darby, Juanita/MSW-0995-2025
OI Patil, Crystal/0000-0003-4536-4599; Li, Hongjin/0000-0002-5466-1192;
   Darby, Juanita/0000-0002-0839-8282
FU National Institutes of Health (NIH) Pragmatic Trials Collaboratory
   through the NIH HEAL Initiative [UG3 AT011265, UH3AT011265]; NIH through
   the NIH HEAL Initiative [U24AT010961]; NCCIH [K24 AT011995, R34
   AT012084]; National Institute of Neurological Disorders and Stroke
   (NINDS); National Cancer Institute (NCI) [R21 CA277153]; Eunice Kennedy
   Shriver National Institute of Child Health and Human Development (NICHD)
   [R01 HD091210]; National Institute of Nursing Research (NINR) [R01
   NR020376]
FX This work was supported within the National Institutes of Health (NIH)
   Pragmatic Trials Collaboratory through the NIH HEAL Initiative under
   award numbers UG3 AT011265 and UH3AT011265 administered by the National
   Center for Complementary and Integrative Health (NCCIH). The work
   received logistical and technical support from the PRISM Resource
   Coordinating Center under award number U24AT010961 from the NIH through
   the NIH HEAL Initiative.This work was also supported by Grant Numbers
   K24 AT011995 from the NCCIH and the National Institute of Neurological
   Disorders and Stroke (NINDS), R34 AT012084 from NCCIH, R21 CA277153 from
   the National Cancer Institute (NCI), R01 HD091210 from the Eunice
   Kennedy Shriver National Institute of Child Health and Human Development
   (NICHD), and R01 NR020376 from the National Institute of Nursing
   Research (NINR). The contentis solely the responsibility of the authors
   and does not necessarily represent the official views of the NCCIH,
   NINDS,NCI, NICHD, NINR, or the NIH or its HEAL Initiative.
CR American Hospital Association, 2023, Fast Facts on U.S. Hospitals, Facilities and Services in the U.S. Census Divisions and States
   Anderson BJ, 2021, J ALTERN COMPLEM MED, V27, P496, DOI 10.1089/acm.2020.0394
   [Anonymous], 2020, CMS finalizes decision to cover acupuncture for chronic low back pain for Medicare beneficiaries
   Bao T, 2018, INTEGR CANCER THER, V17, P854, DOI 10.1177/1534735418754309
   Bhandiwad A., 2020, Fam Doctor J N Y Acad Fam Physicians, V8, P41
   Bleck R, 2021, ACUPUNCT MED, V39, P461, DOI 10.1177/0964528420964214
   Ceniceros S, 1998, SOUTH MED J, V91, P1121, DOI 10.1097/00007611-199812000-00005
   Chen L, 2010, PAIN MED, V11, P530, DOI 10.1111/j.1526-4637.2010.00815.x
   Christopher AS, 2016, AM J PUBLIC HEALTH, V106, P63, DOI 10.2105/AJPH.2015.302925
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   Control CfD. Prevention, 2015, The social-ecological model: A framework for prevention
   Crawford P, 2019, PAIN MED, V20, P1056, DOI 10.1093/pm/pny243
   Fisher CL, 2018, J HEALTH COMMUN, V23, P422, DOI 10.1080/10810730.2018.1458924
   Garland SN, 2021, J CANCER SURVIV, V15, P951, DOI 10.1007/s11764-021-01001-1
   Gong CZ, 2022, MED ACUPUNCT, V34, P83, DOI 10.1089/acu.2021.0049
   Harrison JD, 2019, J ALTERN COMPLEM MED, V25, P503, DOI 10.1089/acm.2018.0348
   Highfield ES, 2008, J ALTERN COMPLEM MED, V14, P629, DOI 10.1089/acm.2008.0021
   Highfield ES, 2003, COMPLEMENT THER MED, V11, P177, DOI 10.1016/S0965-2299(03)00069-4
   Ho EY, 2021, J ALTERN COMPLEM MED, V27, P398, DOI 10.1089/acm.2020.0387
   Hopton A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056806
   Kim J, 2004, AM J CHINESE MED, V32, P321, DOI 10.1142/S0192415X04001977
   Kligler B, 2015, J ALTERN COMPLEM MED, V21, P713, DOI 10.1089/acm.2014.0376
   Ledford CJW, 2018, J AM BOARD FAM MED, V31, P236, DOI 10.3122/jabfm.2018.02.170381
   Li HJ, 2021, J ALTERN COMPLEM MED, V27, P1084, DOI 10.1089/acm.2021.0133
   Li HJ, 2021, ACUPUNCT MED, V39, P612, DOI 10.1177/09645284211017303
   Mann B, 2016, PAIN MED, V17, P494, DOI 10.1093/pm/pnv001
   Mano KEJ, 2009, J ALTERN COMPLEM MED, V15, P661, DOI 10.1089/acm.2008.0449
   Mao JJ, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-7
   McGivney WT, 2010, J NATL COMPR CANC NE, V8, P625, DOI 10.6004/jnccn.2010.0048
   Miller David W, 2021, Glob Adv Health Med, V10, p21649561211042574, DOI [10.1177/21649561211042574, 10.1177/21649561211042574]
   Munn Z, 2020, RADIOGRAPHY, V26, pS8, DOI 10.1016/j.radi.2020.05.008
   Nahin RL, 2024, JAMA-J AM MED ASSOC, V331, P613, DOI 10.1001/jama.2023.26775
   Niemtzow RC, 2020, MED ACUPUNCT, V32, P377, DOI 10.1089/acu.2020.1470
   Page MJ, 2017, SYST REV-LONDON, V6, DOI 10.1186/s13643-017-0663-8
   POLICY D, 2021, Reimbursement policy statement Ohio Medicaid Policy
   Qaseem A, 2017, ANN INTERN MED, V166, P514, DOI 10.7326/M16-2367
   Saper R., 2016, Integrative medicine and health disparities
   Schapira MM, 2014, SUPPORT CARE CANCER, V22, P1207, DOI 10.1007/s00520-013-2073-3
   Street RL, 2012, PATIENT EDUC COUNS, V89, P245, DOI 10.1016/j.pec.2012.06.032
   Taylor-Young P, 2014, MED ACUPUNCT, V26, P208, DOI 10.1089/acu.2013.1017
   Tippens KM, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-293
   Van Hal M., 2024, STATPEARLS INTERNET
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Wang HY, 2018, AM J CHINESE MED, V46, P1387, DOI 10.1142/S0192415X18500738
   Ye HL, 2019, J ALTERN COMPLEM MED, V25, pS17, DOI 10.1089/acm.2018.0399
   Yeh GY, 2008, J EVAL CLIN PRACT, V14, P439, DOI 10.1111/j.1365-2753.2007.00891.x
   Zhu HM, 2014, MED ACUPUNCT, V26, P264, DOI 10.1089/acu.2014.1057
NR 47
TC 4
Z9 4
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2768-3605
EI 2768-3613
J9 J INTEGR COMPLEMENT
JI J. Integr. Complement. Med.
PD 2024 AUG 2
PY 2024
DI 10.1089/jicm.2023.0603
EA AUG 2024
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA A4R3U
UT WOS:001282418300001
PM 39093944
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Lukkahatai, N
   Nguyen, MV
   Zhang, JY
   Cho, YM
   Benjasirisan, C
   Jia, HM
   Campbell, CM
   Kawi, J
   Wu, HL
   Wang, HY
   Bora, R
   Thrul, J
   Johnson, CM
   Smith, TJ
AF Lukkahatai, Nada
   Nguyen, Michael V.
   Zhang, Jingyu
   Cho, Yu-Min
   Benjasirisan, Chitchanok
   Jia, Heijingzi Monica
   Campbell, Claudia M.
   Kawi, Jennifer
   Wu, Hulin
   Wang, Hongyu
   Bora, Rupsikha
   Thrul, Johannes
   Johnson, Constance M.
   Smith, Thomas J.
TI A randomized controlled study of auricular point acupressure to manage
   chemotherapy-induced neuropathy: Study protocol
SO PLOS ONE
LA English
DT Article
ID BREAST-CANCER SURVIVORS; INDUCED PERIPHERAL NEUROPATHY; CLINICAL
   IMPORTANCE; PAIN; ARTHRALGIA; PREVALENCE; PREDICTORS; FATIGUE; SYMPTOMS;
   OUTCOMES
AB Objective Chemotherapy-induced neuropathy (CIN) significantly impacts cancer patients, leading to functional disability, diminished quality of life, and increased healthcare costs amid the ongoing opioid crisis. Auricular point acupressure (APA), a non-invasive and non-pharmacological alternative, has shown potential for alleviating the pain, numbness, and tingling associated with CIN. This study aims to assess the efficacy of APA for CIN symptoms and physical function and to examine the mechanisms underlying APA's effects on CIN.Methods This is a three-arm randomized controlled clinical trial protocol. Patients aged 18 and older who are experiencing CIN are randomly assigned to one of the three groups: an APA group (in-person APA; mAPA), a sham control group (virtual APA; vAPA), and a wait-list usual care control group (UC). During the four-week program, participants in the mAPA receive an in-person APA treatment and training; the sham control participants (vAPA) receive a self-guided smartphone APA application with APA demonstration videos; and the UC participants will continue with the usual care and be re-randomized into one of the APA groups. The primary outcomes are changes in CIN symptoms and physical function. Secondary outcomes include evaluating pain sensory thresholds, motor and cognitive functioning, inflammatory signaling, brain connectivity, opioid use, and quality of life. The outcomes are measured at baseline, program completion (4 weeks), and at monthly follow-up for 3 months post-intervention.Discussion This study will provide evidence supporting the potential viability of APA as an intervention for CIN.Trial registration ClinicalTrials.gov, ID NCT04920097 registered on 3 June 2021.
C1 [Lukkahatai, Nada; Zhang, Jingyu; Benjasirisan, Chitchanok] Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21218 USA.
   [Lukkahatai, Nada] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD 21224 USA.
   [Nguyen, Michael V.; Wang, Hongyu] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Houston, TX USA.
   [Cho, Yu-Min; Kawi, Jennifer; Wang, Hongyu; Bora, Rupsikha; Johnson, Constance M.] Univ Texas Hlth Sci Ctr Houston, Cizik Sch Nursing, Houston, TX USA.
   [Jia, Heijingzi Monica; Thrul, Johannes] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Campbell, Claudia M.; Smith, Thomas J.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Wu, Hulin] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   Medicine; University of Texas System; University of Texas Health Science
   Center Houston; University of Texas System; University of Texas Health
   Science Center Houston; Johns Hopkins University; Johns Hopkins
   Bloomberg School of Public Health; Johns Hopkins University; University
   of Texas System; University of Texas Health Science Center Houston;
   University of Texas School Public Health
RP Lukkahatai, N (corresponding author), Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21218 USA.; Lukkahatai, N (corresponding author), Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD 21224 USA.
EM nada.lukkahatai@jhu.edu
RI Smith, Thomas/K-9086-2013; Kawi, Jennifer/AAN-4262-2021; Lukkahatai,
   Nada/GQA-9711-2022; Benjasirisan, Chitchanok/KVB-0474-2024
OI Lukkahatai, Nada/0000-0003-3820-1812; Benjasirisan,
   Chitchanok/0000-0001-6465-0721; Nguyen, Michael/0000-0002-6580-5921
FU National Cancer Institute of the National Institutes of Health
   [R01CA245054]
FX NL, CMJ, TJS, CMC, JT are supported by the National Cancer Institute of
   the National Institutes of Health under (https://www.cancer.gov/), under
   the award number R01CA245054. the funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Agresti A., 2002, Categorical data analysis, VSecond, DOI DOI 10.1002/0471249688
   [Anonymous], 2005, Auricular Medicine: A Complete Manual of Auricular Diagnosis and Treatment
   Bakhtiari-Dovvombaygi H, 2021, N-S ARCH PHARMACOL, V394, P655, DOI 10.1007/s00210-020-02002-0
   Bauml J, 2015, BREAST CANCER RES, V17, DOI 10.1186/s13058-015-0599-7
   Brier MJ, 2015, CANCER-AM CANCER SOC, V121, P2808, DOI 10.1002/cncr.29407
   Campbell CM, 2016, PAIN, V157, P949, DOI 10.1097/j.pain.0000000000000473
   Campbell CM, 2009, TRANSL RES, V153, P97, DOI 10.1016/j.trsl.2008.12.002
   Cashion AK, 2015, NURS OUTLOOK, V63, P484, DOI 10.1016/j.outlook.2015.03.001
   Chen XY, 2015, MOL PAIN, V11, DOI 10.1186/s12990-015-0071-9
   CMS) CfMMS, 2018, The 2019 Rate Announcement and Call Letter:and selecting 2019 Announcement.
   Craig BM, 2014, VALUE HEALTH, V17, P846, DOI 10.1016/j.jval.2014.09.005
   Desai K, 2013, SUPPORT CARE CANCER, V21, P43, DOI 10.1007/s00520-012-1490-z
   Dworkin RH, 2008, J PAIN, V9, P105, DOI 10.1016/j.jpain.2007.09.005
   Farrar JT, 2001, PAIN, V94, P149, DOI 10.1016/S0304-3959(01)00349-9
   Furlan AD, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/953139
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Hsu C, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-276
   Hua S, 2013, FRONT PHARMACOL, V4, DOI 10.3389/fphar.2013.00142
   Li K, 2019, CURR ONCOL, V26, pE147, DOI 10.3747/co.26.4261
   Lin WC, 2019, CIN-COMPUT INFORM NU, V37, P276, DOI 10.1097/CIN.0000000000000478
   Little R.J.A., 2002, Statistical Analysis with Missing Data, V2nd, DOI [DOI 10.1002/9781119013563, https://doi.org/10.1002/9781119013563.ch10]
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Lumley MA, 2011, J CLIN PSYCHOL, V67, P942, DOI 10.1002/jclp.20816
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Markovitz LC, 2017, PSYCHO-ONCOLOGY, V26, P2294, DOI 10.1002/pon.4362
   Nahin Richard L, 2016, NCHS Data Brief, P1
   Nogier P., 1987, Maisonneuve SA: Moulin Les-Metz, France
   Nogier R, 2014, MED ACUPUNCT, V26, P76, DOI 10.1089/acu.2014.1035
   Oberguggenberger A, 2018, CLIN BREAST CANCER, V18, P38, DOI 10.1016/j.clbc.2017.09.008
   Oleson T., 2014, Auriculotherapy Manual: Chinese and Western Systems of Ear Acupuncture
   Pike Crystal T, 2012, Chemother Res Pract, V2012, P913848, DOI 10.1155/2012/913848
   Qiu S, 2013, SCI SIGNAL, V6, DOI 10.1126/scisignal.2003778
   Roldan CJ, 2018, PAIN PHYSICIAN, V21, pE419, DOI 10.36076/ppj.2018.4.e419
   Romoli M, 2014, NEUROL SCI, V35, pS189, DOI 10.1007/s10072-014-1768-7
   Schafer LM, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-234
   Schapira MM, 2014, SUPPORT CARE CANCER, V22, P1207, DOI 10.1007/s00520-013-2073-3
   Schnur JB, 2007, PERS INDIV DIFFER, V42, P419, DOI 10.1016/j.paid.2006.07.009
   Selvy M, 2020, J CLIN MED, V9, DOI 10.3390/jcm9082400
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Shelton RC, 2013, BREAST CANCER RES TR, V137, P817, DOI 10.1007/s10549-012-2370-4
   Simon NB, 2017, QUAL LIFE RES, V26, P2763, DOI 10.1007/s11136-017-1635-0
   Sisignano M, 2014, NAT REV NEUROL, V10, P694, DOI 10.1038/nrneurol.2014.211
   Smith TJ, 2020, J PALLIAT CARE, V35, P53, DOI 10.1177/0825859719827589
   Verbeke G., 2000, LINEAR MIXED MODELS
   Verbeke G, 2009, SPRINGER SER STAT, P1
   Vickers AJ, 2010, TRIALS, V11, DOI 10.1186/1745-6215-11-90
   Winters-Stone KM, 2017, J CLIN ONCOL, V35, P2604, DOI 10.1200/JCO.2016.71.3552
   Woolf CJ, 2011, PAIN, V152, pS2, DOI 10.1016/j.pain.2010.09.030
   Yeh CH., 2018, Johns Hopkins University: National Institutes of Health
   Yeh Chao Hsing, 2020, Glob Adv Health Med, V9, p2164956120906092, DOI [10.1177/2164956120906092, 10.1177/2164956120906092]
   Yeh CH, 2020, TRIALS, V21, DOI 10.1186/s13063-019-4016-x
   Yeh CH, 2019, PAIN MANAG NURS, V20, P623, DOI 10.1016/j.pmn.2019.04.004
   Yeh CH, 2019, PAIN MANAG NURS, V20, P614, DOI 10.1016/j.pmn.2019.04.005
   Yeh CH, 2017, ONCOL NURS FORUM, V44, P476, DOI 10.1188/17.ONF.476-487
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Yeh CH, 2015, PAIN MED, V16, P1857, DOI 10.1111/pme.12789
   Yeh CH, 2013, MED ACUPUNCT, V25, P423, DOI 10.1089/acu.2013.1006
   Yeh CH, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/375173
NR 59
TC 3
Z9 4
U1 6
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 26
PY 2024
VL 19
IS 9
AR e0311135
DI 10.1371/journal.pone.0311135
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA H0Y1U
UT WOS:001320777500024
PM 39325795
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Shalom-Sharabi, I
   Samuels, N
   Lev, E
   Lavie, O
   Keinan-Boker, L
   Schiff, E
   Ben-Arye, E
AF Shalom-Sharabi, Ilanit
   Samuels, Noah
   Lev, Efraim
   Lavie, Ofer
   Keinan-Boker, Lital
   Schiff, Elad
   Ben-Arye, Eran
TI Impact of a complementary/integrative medicine program on the need for
   supportive cancer care-related medications
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Integrative medicine; Supportive care; Medication use; Complementary
   medicine; Chemotherapy
ID RANDOMIZED CONTROLLED-TRIAL; CHEMOTHERAPY-INDUCED NAUSEA; BREAST-CANCER;
   ONCOLOGY; PAIN; ELECTROACUPUNCTURE; ACUPUNCTURE; ARTHRALGIA; PREVENTION;
   ADHERENCE
AB Despite the growing evidence supporting the use of complementary/integrative medicine (CIM) in the treatment of chemotherapy-induced toxicities, little is known on CIM impact of these therapies regarding the use of medications for supportive cancer care. In this study, we examined the impact of CIM on the need for supportive cancer care-related medications.
   Patients with breast or gynecological cancer referred to and attending an integrative physician (IP) consultation for gastrointestinal (GI) concerns were designated as the treatment group; those not attending as controls. Adherence to the integrative care program (AIC) was defined as attending >= 4 CIM interventions. The need for conventional supportive care-related medications and doses was determined from patients' medical files, as well as the implications on the potential for cost reduction.
   Of the 205 patients diagnosed with GI concerns, 116 attended the IP consultation and weekly CIM treatments (56.6%; treatment group), of which 85 (73.3%) were adherent to the program (AIC subgroup); 89 did not undergo an IP consultation (43.4%; controls). Within-group analysis found a greater decrease in the use of non-opioid analgesics (NOAs) at 6 weeks in the treatment group (P = 0.01), more so in the AIC subgroup (P = 0.02). A cost analysis suggests that reduced NOA use in the treatment group reduced the cost of supportive care, covering 27.1% of the overall expense of CIM treatments. Controls were less likely to require anti-emetics (P = 0.007). Between-group analysis showed a trend for reduced use of anxiolytics (P = 0.06) and NOAs (P = 0.08) among treated patients, with lower dose equivalents for NOAs than controls (P < 0.001).
   CIM treatments may reduce the need for NOAs among patients with breast or gynecological cancer.
C1 [Shalom-Sharabi, Ilanit; Samuels, Noah; Ben-Arye, Eran] Clalit Hlth Serv, Lin Med Ctr, Oncol Serv, Integrat Oncol Program, 35 Rothschild St, Haifa, Israel.
   [Shalom-Sharabi, Ilanit] Univ Haifa, Grad Studies Author, Haifa, Israel.
   [Samuels, Noah] Sheba Med Ctr, Inst Oncol, Tal Ctr Integrat Med, Tel Hashomer, Israel.
   [Lev, Efraim] Univ Haifa, Dept Israel Studies, Haifa, Israel.
   [Lavie, Ofer] Carmel Hosp, Dept Obstet & Gynecol, Gynecol Oncol Serv, Haifa, Israel.
   [Keinan-Boker, Lital] Univ Haifa, Sch Publ Hlth, Fac Social Welf & Hlth Sci, Haifa, Israel.
   [Keinan-Boker, Lital] Israel Minist Hlth, Israel Ctr Dis Control, Jerusalem, Israel.
   [Schiff, Elad] Bnai Zion Hosp, Dept Internal Med, Haifa, Israel.
   [Schiff, Elad] Bnai Zion Hosp, Integrat Med Serv, Haifa, Israel.
   [Ben-Arye, Eran] Technion Israel Inst Technol, Dept Family Med, Complementary & Tradit Med Unit, Fac Med, Haifa, Israel.
C3 Clalit Health Services; University of Haifa; Tel Aviv University; Chaim
   Sheba Medical Center; University of Haifa; Clalit Health Services;
   Carmel Medical Center; University of Haifa; Ministry of Health - Israel;
   Bnai Zion Medical Center; Bnai Zion Medical Center; Technion Israel
   Institute of Technology; Rappaport Faculty of Medicine
RP Ben-Arye, E (corresponding author), Clalit Hlth Serv, Lin Med Ctr, Oncol Serv, Integrat Oncol Program, 35 Rothschild St, Haifa, Israel.; Ben-Arye, E (corresponding author), Technion Israel Inst Technol, Dept Family Med, Complementary & Tradit Med Unit, Fac Med, Haifa, Israel.
EM eranben@netvision.net.il
OI Lev, Efraim/0000-0002-9914-4164
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Ben-Arye E, 2015, CLIN NUTR, V34, P1215, DOI 10.1016/j.clnu.2014.12.011
   Ben-Arye E, 2015, SUPPORT CARE CANCER, V23, P3411, DOI 10.1007/s00520-015-2690-0
   Ben-Arye E, 2014, SUPPORT CARE CANCER, V22, P627, DOI 10.1007/s00520-013-2016-z
   Ben-Arye E, 2013, MED ONCOL, V30, DOI 10.1007/s12032-013-0511-1
   Ben-Arye E, 2012, PATIENT EDUC COUNS, V89, P423, DOI 10.1016/j.pec.2012.02.011
   Binkhorst L, 2013, BREAST CANCER RES TR, V139, P923, DOI 10.1007/s10549-013-2585-z
   Briesacher BA, 2007, J GEN INTERN MED, V22, P864, DOI 10.1007/s11606-007-0180-x
   Bruera E, 1991, J Palliat Care, V7, P6
   Butler LD, 2009, HEALTH PSYCHOL, V28, P579, DOI 10.1037/a0016124
   Chan Alexandre, 2012, J Manag Care Pharm, V18, P385
   Charalambous A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156911
   Kligler B, 2011, AM J MANAG CARE, V17, P779
   Kutner JS, 2008, ANN INTERN MED, V149, P369, DOI 10.7326/0003-4819-149-6-200809160-00003
   Levine ME, 2008, J ALTERN COMPLEM MED, V14, P545, DOI 10.1089/acm.2007.0817
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Mardby AC, 2007, PATIENT EDUC COUNS, V69, P158, DOI 10.1016/j.pec.2007.08.011
   Mir O, 2012, SUPPORT CARE CANCER, V20, P2235, DOI 10.1007/s00520-012-1503-y
   Molassiotis A, 2002, SUPPORT CARE CANCER, V10, P237, DOI 10.1007/s00520-001-0329-9
   Montgomery GH, 2007, JNCI-J NATL CANCER I, V99, P1304, DOI 10.1093/jnci/djm106
   Oldenmenger WH, 2013, J PAIN SYMPTOM MANAG, V45, P1083, DOI 10.1016/j.jpainsymman.2012.06.007
   Park JW, 2016, J CANCER RES CLIN, V142, P1031, DOI 10.1007/s00432-015-2108-x
   Pfister DG, 2010, J CLIN ONCOL, V28, P2565, DOI 10.1200/JCO.2009.26.9860
   Rithirangsriroj K, 2015, GYNECOL ONCOL, V136, P82, DOI 10.1016/j.ygyno.2014.10.025
   Roila F, 2010, ANN ONCOL, V21, pv232, DOI 10.1093/annonc/mdq194
   Ryan JL, 2012, SUPPORT CARE CANCER, V20, P1479, DOI 10.1007/s00520-011-1236-3
   Sharabi IS, 2016, SUPPORT CARE CANCER, V24, P4345, DOI 10.1007/s00520-016-3274-3
   Song QH, 2013, INT J CLIN EXP MED, V6, P979
   Van Gool AR, 2010, PHARM WORLD SCI, V32, P704, DOI 10.1007/s11096-010-9444-3
   Wilkinson SM, 2007, J CLIN ONCOL, V25, P532, DOI 10.1200/JCO.2006.08.9987
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Zhao J, 2013, PHARMAZIE, V68, P421, DOI 10.1691/ph.2013.2876
NR 34
TC 16
Z9 16
U1 3
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD OCT
PY 2017
VL 25
IS 10
BP 3181
EP 3190
DI 10.1007/s00520-017-3726-4
PG 10
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA FF2KZ
UT WOS:000408727600024
PM 28434097
DA 2026-01-16
ER

PT J
AU Baccetti, S
   Da Frè, M
   Becorpi, A
   Faedda, M
   Guerrera, A
   Monechi, MV
   Munizzi, RM
   Parazzini, F
AF Baccetti, Sonia
   Da Fre, Monica
   Becorpi, Angelamaria
   Faedda, Marina
   Guerrera, Antonella
   Monechi, M. Valeria
   Munizzi, Rosa Maria
   Parazzini, Fabio
TI Acupuncture and Traditional Chinese Medicine for Hot Flushes in
   Menopause: A Randomized Trial
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID POSTMENOPAUSAL WOMEN; VASOMOTOR SYMPTOMS; BREAST-CANCER; FLASHES;
   PLACEBO; PERIMENOPAUSAL; ESTROGEN; SAFETY
AB Objective: To evaluate the effect of acupuncture on hot flushes and other menopause-related symptoms used in an integrated system, including such therapeutic techniques as diet therapy and Tuina self-massage.
   Design: Randomized trial.
   Setting: Outpatient center.
   Participants: One hundred women in spontaneous menopause with at least three episodes of hot flushes daily were randomly allocated to two treatment groups (50 per group): Women in group A were given diet, self-massage training, and treatment with acupuncture, and women in group B (the control group) were given the same diet and self-massage training, but treatment with acupuncture started 6 weeks after they were enrolled into the study.
   Intervention: Acupuncture treatments were scheduled twice weekly for 6 consecutive weeks.
   Outcome measures: Mean change in frequency and/or intensity in menopause-related symptoms were estimated by questionnaire after treatment at week 4.
   Results: Treatment with acupuncture significantly reduced the occurrence of hot flushes and sudden sweating (p<.001). Other symptoms (sleep disorders, tightness in the chest, irritability, bone pain, feeling depressed) significantly improved.
   Conclusions: Acupuncture in an integrated system that includes therapeutic techniques such as diet therapy and Tuina self-massage can be used to treat hot flushes and selected symptoms in postmenopausal women.
C1 [Baccetti, Sonia; Faedda, Marina; Guerrera, Antonella; Monechi, M. Valeria; Munizzi, Rosa Maria] Referring Ctr Complementary Med, San Donnino, Campi Bisenzio, Italy.
   [Da Fre, Monica] Reg Hlth Agcy Tuscany, Epidemiol Unit, Florence, Italy.
   [Becorpi, Angelamaria] AOU Careggi, Italian Soc Gynaecol Elderly Age, Dept Obstet & Gynaecol, Florence, Italy.
   [Parazzini, Fabio] Univ Milan, Fdn IRCCS Policlin, Dept Obstet & Gynecol, I-20122 Milan, Italy.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi;
   University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico
RP Parazzini, F (corresponding author), Univ Milan, Fdn IRCCS Policlin, Dept Obstet & Gynecol, Via Commenda 12, I-20122 Milan, Italy.
EM fabio.parazzini@unimi.it
RI parazzini, fabio/IQT-2942-2023
OI parazzini, fabio/0000-0001-5624-4854
CR Alraek T, 2009, J ALTERN COMPLEM MED, V15, P153, DOI 10.1089/acm.2008.0310
   Anderson GL, 2004, JAMA-J AM MED ASSOC, V291, P1701, DOI 10.1001/jama.291.14.1701
   [Anonymous], EVID BASED COMPLEMEN
   Avis NE, 2008, MENOPAUSE, V15, P1070, DOI 10.1097/gme.0b013e31816d5b03
   Bologna M, 1999, DIETETICA MED SCI TR
   Borud EK, 2009, MENOPAUSE, V16, P484, DOI 10.1097/gme.0b013e31818c02ad
   Cabyoglu MT, 2006, INT J NEUROSCI, V116, P115, DOI 10.1080/00207450500341472
   Cai Jingfeng, 1995, DIETETICA CINESE
   Cho SH, 2009, MENOPAUSE, V16, P1065, DOI 10.1097/gme.0b013e3181a48abd
   Cohen Susan M, 2003, Holist Nurs Pract, V17, P295
   De Aloysio D, 2001, MENOPAUSE, V8, P290
   Ernst E, 2001, AM J MED, V110, P481, DOI 10.1016/S0002-9343(01)00651-9
   Hervik J, 2009, BREAST CANCER RES TR, V116, P311, DOI 10.1007/s10549-008-0210-3
   Huang MI, 2006, FERTIL STERIL, V86, P700, DOI 10.1016/j.fertnstert.2006.02.100
   Hulley S, 1998, JAMA-J AM MED ASSOC, V280, P605, DOI 10.1001/jama.280.7.605
   Kim DI, 2011, ACUPUNCT MED, V29, P249, DOI 10.1136/aim.2011.004085
   Kim KH, 2010, MENOPAUSE, V17, P269, DOI 10.1097/gme.0b013e3181bfac3b
   Lee MS, 2009, CLIMACTERIC, V12, P16, DOI 10.1080/13697130802566980
   Lee MS, 2009, BREAST CANCER RES TR, V115, P497, DOI 10.1007/s10549-008-0230-z
   Lund Irene, 2006, Acupunct Med, V24, P13
   Lund Irene, 2009, Chin Med, V4, P1, DOI 10.1186/1749-8546-4-1
   Maciocia G, 2002, OSTETRICIA GINECOLOG
   Mollard Brusini Y, 2004, DIETETICA CINESE 2 T
   Muccioli M, 2001, DIETETICA TRADIZIONA, VI
   Muccioli M, 2001, DIETETICA TRADIZIONA, VII
   Painovich JM, 2012, MENOPAUSE, V19, P54, DOI 10.1097/gme.0b013e31821f9171
   Shen X, 2006, J TRADIT CHIN MED, V25, P3
   Sherman Sherry, 2005, Am J Med, V118 Suppl 12B, P166, DOI 10.1016/j.amjmed.2005.12.004
   Sotte L, 2011, DIETETICA CINESE TRA
   Spence DW, 2004, J NEUROPSYCH CLIN N, V16, P19, DOI 10.1176/appi.neuropsych.16.1.19
   Uchida S, 2008, EVID-BASED COMPL ALT, V5, P145, DOI 10.1093/ecam/nem051
   Venzke L, 2010, COMPLEMENT THER MED, V18, P59, DOI 10.1016/j.ctim.2010.02.002
   Vickers AJ, 2002, EVAL HEALTH PROF, V25, P421, DOI 10.1177/0163278702238055
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   White Adrian, 2004, Acupunct Med, V22, P122
   White AR, 2003, J FAM PLAN REPROD H, V29, P233, DOI 10.1783/147118903101197863
   Witt CM, 2009, FORSCH KOMPLEMENTMED, V16, P91, DOI 10.1159/000209315
   Zaborowska E, 2007, CLIMACTERIC, V10, P38, DOI 10.1080/13697130601165059
NR 38
TC 17
Z9 17
U1 0
U2 41
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD JUL
PY 2014
VL 20
IS 7
BP 550
EP 557
DI 10.1089/acm.2012.0499
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AL5VO
UT WOS:000339201600005
PM 24827469
DA 2026-01-16
ER

PT J
AU Walter, M
   Sammer, U
   Kessler, TM
AF Walter, M.
   Sammer, U.
   Kessler, T. M.
TI Chronic pelvic pain syndrome. Neurostimulation, neuromodulation and
   acupuncture
SO UROLOGE
LA German
DT Article
DE Non-malignant pain; Pelvis; Neurostimulation; Neuromodulation;
   Acupuncture
ID TIBIAL NERVE-STIMULATION; REFRACTORY INTERSTITIAL CYSTITIS;
   URINARY-TRACT DYSFUNCTION; SACRAL NEUROMODULATION; VOIDING DYSFUNCTION;
   RANDOMIZED-TRIAL; SUBTHALAMIC STIMULATION; PARKINSONS-DISEASE; FLOOR
   DYSFUNCTION; CROSSOVER TRIAL
AB Chronic pelvic pain syndrome (CPPS) is defined by the European Association of Urology guidelines as a non-malignant pain perceived in structures related to the pelvis of either women or men for at least 6 months without proven infection or other obvious pathology. It affects the quality of life of millions of people worldwide and has an impact similar to that reported for other chronic diseases, such as diabetes mellitus, Crohn's disease and congestive heart failure. The treatment of CPPS remains a challenge despite several established first line therapies because many patients are therapy refractory. Unconventional treatments, such as neurostimulation, neuromodulation and acupuncture may be highly successful for treating CPPS and have a favorable adverse event profile. Thus, these promising therapeutic alternatives should be considered more often in daily clinical practice.
C1 [Walter, M.; Sammer, U.; Kessler, T. M.] Univ Zurich, Uniklin Balgrist, Zentrum Paraplegie, CH-8008 Zurich, Switzerland.
C3 University of Zurich
RP Kessler, TM (corresponding author), Univ Zurich, Uniklin Balgrist, Zentrum Paraplegie, Forchstr 340, CH-8008 Zurich, Switzerland.
EM tkessler@gmx.ch
RI Walter, Matthias/ABB-9592-2020
OI Walter, Matthias/0000-0001-5347-1584
CR Aboseif S, 2002, UROLOGY, V60, P52, DOI 10.1016/S0090-4295(02)01630-8
   ACOG Committee on Practice Bulletins--Gynecology, 2004, Obstet Gynecol, V103, P589
   American Urological Association, 2011, GUID DIAGN TREATM IC
   [Anonymous], EAU GUIDELINES CHRON
   Anothaisintawee T, 2011, JAMA-J AM MED ASSOC, V305, P78, DOI 10.1001/jama.2010.1913
   Rodríguez MAB, 2009, J UROLOGY, V182, P2123, DOI 10.1016/j.juro.2009.07.036
   Capodice Jillian L, 2007, Chin Med, V2, P1, DOI 10.1186/1749-8546-2-1
   Capodice JL, 2005, EVID-BASED COMPL ALT, V2, P495, DOI 10.1093/ecam/neh128
   Cardarelli Sofia, 2012, Urologia, V79, P90, DOI 10.5301/RU.2012.9278
   Chen R, 2003, UROLOGY, V61, P1156, DOI 10.1016/S0090-4295(03)00141-9
   Chen Richard C T, 2004, Curr Urol Rep, V5, P305, DOI 10.1007/s11934-004-0057-z
   Collins MM, 2001, J GEN INTERN MED, V16, P656
   Comiter CV, 2003, J UROLOGY, V169, P1369, DOI 10.1097/01.ju.0000053863.96967.5a
   Deadman P., 1998, J CHIN MED
   Elhlali MM, 2005, UROLOGY, V65, P1114, DOI 10.1016/j.urology.2004.12.016
   Ellis A., 1991, FUNDAMENTALS CHINESE, VRevis
   Everaert K, 2004, EUR UROL, V45, P649, DOI 10.1016/j.eururo.2003.11.015
   Everaert K, 2001, INT UROGYNECOL J PEL, V12, P9, DOI 10.1007/s001920170087
   Fall M, 2010, EUR UROL, V57, P35, DOI 10.1016/j.eururo.2009.08.020
   Fenton BW, 2009, BRAIN STIMUL, V2, P103, DOI 10.1016/j.brs.2008.09.009
   Haake M, 2007, ARCH INTERN MED, V167, P1892, DOI 10.1001/archinte.167.17.1892
   Herzog J, 2008, BRAIN, V131, P132, DOI 10.1093/brain/awm254
   Herzog J, 2006, BRAIN, V129, P3366, DOI 10.1093/brain/awl302
   Honjo H, 2004, INT J UROL, V11, P607, DOI 10.1111/j.1442-2042.2004.00868.x
   HOSOBUCHI Y, 1986, J NEUROSURG, V64, P543, DOI 10.3171/jns.1986.64.4.0543
   International Association for the Study of Pain, 2003, PAIN CLIN UPD PREV C
   International Association for the Study of Pain, 2008, PAIN CLIN UPD CHRON
   Kessler TM, 2008, CURR MED RES OPIN, V24, P343, DOI 10.1185/030079908X253555
   Kessler TM, 2008, EUR UROL, V53, P607, DOI 10.1016/j.eururo.2007.07.015
   Kessler TM, 2007, EUR UROL, V51, P1357, DOI 10.1016/j.eururo.2006.11.011
   Kim SW, 2007, UROL INT, V78, P58, DOI 10.1159/000096936
   Krieger JN, 1999, JAMA-J AM MED ASSOC, V282, P236, DOI 10.1001/jama.282.3.236
   Lavano A, 2004, J Neurosurg Sci, V48, P157
   Lee Sang-Hun, 2011, Curr Urol Rep, V12, P288, DOI 10.1007/s11934-011-0186-0
   Lee SH, 2009, UROLOGY, V73, P1036, DOI 10.1016/j.urology.2008.10.047
   Lee SWH, 2008, AM J MED, V121, DOI 10.1016/j.amjmed.2007.07.033
   Maher CF, 2001, J UROLOGY, V165, P884, DOI 10.1016/S0022-5347(05)66551-2
   Marszalek M, 2009, EUR UROL, V55, P499, DOI 10.1016/j.eururo.2008.03.073
   Martellucci J, 2012, INT J COLORECTAL DIS, V27, P921, DOI 10.1007/s00384-011-1394-2
   Nickel JC, 2004, J UROLOGY, V172, P551, DOI 10.1097/01.ju.0000131592.98562.16
   Otto W, 2012, AKTUEL UROL, V43, P162, DOI 10.1055/s-0031-1284024
   Pannek J, 2003, UROLOGE A, V42, P1470, DOI 10.1007/s00120-003-0369-5
   Parsons CL, 2007, UROLOGY, V69, P9, DOI 10.1016/j.urology.2006.03.084
   Peters KM, 2007, BJU INT, V100, P835, DOI 10.1111/j.1464-410X.2007.07082.x
   Peters KM, 2010, NEUROUROL URODYNAM, V29, P1267, DOI 10.1002/nau.20823
   Peters KM, 2005, NEUROUROL URODYNAM, V24, P643, DOI 10.1002/nau.20174
   Peters KM, 2004, BJU INT, V93, P777, DOI 10.1111/j.1464-410X.2003.04745.x
   Pham K, 2008, NEUROUROL URODYNAM, V27, P779, DOI 10.1002/nau.20577
   Posadzki P, 2011, J ANDROL, V33, P15, DOI 10.2164/jandrol.111.013235
   Potts JM, 2012, PAIN, V153, P755, DOI 10.1016/j.pain.2011.10.005
   Powell CR, 2010, J UROLOGY, V183, P173, DOI 10.1016/j.juro.2009.08.142
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Scheepens WA, 2002, J UROLOGY, V168, P2046, DOI 10.1016/S0022-5347(05)64292-9
   Shoskes Daniel A, 2005, Curr Urol Rep, V6, P296, DOI 10.1007/s11934-005-0027-0
   Sibert L, 2010, PROG UROL, V20, P872, DOI 10.1016/j.purol.2010.08.004
   Siegel S, 2001, J UROLOGY, V166, P1742, DOI 10.1016/S0022-5347(05)65665-0
   Sikiru L, 2008, INT BRAZ J UROL, V34, P708, DOI 10.1590/S1677-55382008000600005
   Stojanovic M P, 2001, Curr Pain Headache Rep, V5, P130, DOI 10.1007/s11916-001-0081-3
   Stux G., 2007, AKUPUNKTUR
   Suh Lara K, 2011, Curr Urol Rep, V12, P284, DOI 10.1007/s11934-011-0188-y
   The British Pain Society, 2006, FAQ WHAT IS DEF CHRO
   Tugcu V, 2010, PAIN MED, V11, P518, DOI 10.1111/j.1526-4637.2009.00794.x
   van Balken MR, 2006, INT J IMPOT RES, V18, P470, DOI 10.1038/sj.ijir.3901457
   van Balken MR, 2003, EUR UROL, V43, P158, DOI 10.1016/S0302-2838(02)00552-3
   Wenninger K, 1996, J UROLOGY, V155, P965, DOI 10.1016/S0022-5347(01)66359-6
   Westesson Karin E, 2010, Curr Urol Rep, V11, P261, DOI 10.1007/s11934-010-0111-y
   Wöllner J, 2012, BJU INT, V110, P146, DOI 10.1111/j.1464-410X.2012.10906.x
   Zabihi N, 2008, INT UROGYNECOL J, V19, P553, DOI 10.1007/s00192-007-0466-x
NR 68
TC 4
Z9 6
U1 0
U2 17
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-2592
EI 1433-0563
J9 UROLOGE
JI Urologe
PD DEC
PY 2012
VL 51
IS 12
BP 1683
EP +
DI 10.1007/s00120-012-3037-9
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 053FX
UT WOS:000312257500005
PM 23224254
OA Green Published
DA 2026-01-16
ER

PT J
AU Yang, MX
   Zhong, LD
   Fok, RWY
   Tjioe, YY
   Teo, BS
   Zhang, FR
   Bao, T
AF Yang, Mingxiao
   Zhong, Linda
   Fok, Rose W. Y.
   Tjioe, Yan Yin
   Teo, Bo Siang
   Zhang, Furong
   Bao, Ting
TI Effects and safety of traditional Chinese medicine approaches in cancer
   symptom care: A systematic review of phase 3 randomized clinical trials
SO CANCER
LA English
DT Review
DE acupuncture; herbal therapies; neoplasms; phase 3 clinical trials;
   symptom burden; systematic review; Tai Chi; traditional Chinese medicine
ID HERBAL MEDICINE; BREAST-CANCER; DOUBLE-BLIND; ACUPUNCTURE; THERAPY;
   FATIGUE
AB Cancer-related symptoms are detrimental to the quality of life of people with cancer. This review systematically evaluates phase 3 randomized clinical trials (RCTs) assessing the effectiveness and safety of traditional Chinese medicine (TCM) interventions in managing cancer-related symptoms throughout the cancer care trajectory. A comprehensive literature search was conducted of PubMed, Embase, and the Cochrane Library until April 27, 2025, to further identify eligible RCTs involving patients with cancer or survivors and assessing TCM interventions against valid control arms. Data extraction and quality assessments were conducted in accordance with Cochrane standards and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Nineteen phase 3 RCTs involving 5387 participants (female, 3321; primarily breast, gastrointestinal, and lung cancers) from six countries or regions were included. Nonpharmacological interventions, namely acupuncture and Tai Chi, significantly reduced pain, fatigue, insomnia, radiation-induced xerostomia, and hormonal therapy-related hot flashes compared to usual care (UC). Their effects on preventing chemotherapy- and radiotherapy-induced nausea and vomiting were mixed, which depended on control arms and outcome measures. Conversely, evidence for pharmacological interventions was limited, with inconclusive results regarding chemotherapy-induced peripheral neuropathy and hematologic toxicities, although promising outcomes were noted for preventing chemoradiotherapy-induced mucositis, reducing colorectal adenoma recurrence, and enhancing chemotherapy completion rates compared to placebo or UC. Safety data suggested similar adverse event profiles across groups. These findings show strong evidence for the inclusion of nonpharmacological interventions in oncology practice. However, pharmacological interventions require more high-quality, multicenter research to fully understand their effectiveness and safety. Implementing rigorous safety assessments and standardized adverse event reporting protocols is crucial to enhance clinical confidence in TCM modalities.
C1 [Yang, Mingxiao; Zhong, Linda; Tjioe, Yan Yin; Teo, Bo Siang] Nanyang Technol Univ, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore.
   [Fok, Rose W. Y.] Natl Canc Ctr Singapore, Div Med Oncol, Singapore, Singapore.
   [Zhang, Furong] Chengdu Univ Tradit Chinese Med, Coll Hlth Preservat & Rehabil, Chengdu, Sichuan, Peoples R China.
   [Bao, Ting] Dana Farber Canc Inst, Boston, MA USA.
   [Bao, Ting] Harvard Med Sch, Boston, MA USA.
C3 Nanyang Technological University; National Cancer Centre Singapore
   (NCCS); Chengdu University of Traditional Chinese Medicine; Harvard
   University; Harvard University Medical Affiliates; Dana-Farber Cancer
   Institute; Harvard University; Harvard Medical School
RP Yang, MX (corresponding author), Nanyang Technol Univ, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore.
EM mingxiao.yang@ntu.edu.sg
RI ; Tjioe, Yan Yin/MTA-1473-2025; Yang, Mingxiao/ABF-6416-2021
OI Fok, Rose/0000-0002-3926-6354; 
FU Nanyang Technological University [025273-00001]
FX Mingxiao Yang is supported by a start-up grant, the Integrative Oncology
   in Singapore (IO@SG) Project (025273-00001), from Nanyang Technological
   University.
CR Bergerot CD, 2025, JCO GLOB ONCOL, V11, DOI 10.1200/GO-24-00625
   Bower JE, 2024, J CLIN ONCOL, V42, DOI 10.1200/JCO.24.00541
   Bubis LD, 2018, J CLIN ONCOL, V36, P1103, DOI 10.1200/JCO.2017.76.0876
   Carlson LE, 2023, J CLIN ONCOL, V41, P4562, DOI 10.1200/JCO.23.00857
   Cheng CW, 2017, ANN INTERN MED, V167, P112, DOI [10.7326/M16-2977, 10.7326/IsTranslatedFrom_M17-2977_2, 10.7326/IsTranslatedFrom_M17-2977_1]
   Cleeland Charles S, 2007, J Natl Cancer Inst Monogr, P16
   Cochrane Collaboration, 2020, Review Manager (RevMan)
   Cohen L, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.10421
   Duan XY, 2025, CHIN MED-UK, V20, DOI 10.1186/s13020-025-01156-4
   Enblom A, 2012, ANN ONCOL, V23, P1353, DOI 10.1093/annonc/mdr402
   Epstein AS, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.42482
   Fai CK, 2011, RECENT PATENTS INFLA, V5, P169, DOI 10.2174/187221311795399237
   Fasinu PS, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.01356
   Garcia MK, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.16910
   Gupta S, 2023, CANCER MED-US, V12, P11773, DOI 10.1002/cam4.5837
   Henry DH, 2008, SUPPORT CARE CANCER, V16, P791, DOI 10.1007/s00520-007-0380-2
   Herrstedt J, 2024, ESMO OPEN, V9, DOI 10.1016/j.esmoop.2023.102195
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Higgins J., 2023, Methodological Expectations of Cochrane Intervention Reviews
   Konno Y, 2025, INTEGR CANCER THER, V24, DOI 10.1177/15347354251329346
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Liu YM, 2023, PHYTOMEDICINE, V113, DOI 10.1016/j.phymed.2023.154723
   Lopez G, 2024, NAT REV CANCER, V24, P739, DOI 10.1038/s41568-024-00735-1
   Loprinzi CL, 2020, J CLIN ONCOL, V38, DOI 10.1200/JCO.20.01399
   Lu CL, 2021, INTEGR CANCER THER, V20, DOI 10.1177/15347354211031650
   Luo YK, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/8692343
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mao JJ, 2022, CA-CANCER J CLIN, V72, P144, DOI 10.3322/caac.21706
   Mao JJ, 2021, JAMA ONCOL, V7, P720, DOI 10.1001/jamaoncol.2021.0310
   Mok TSK, 2007, ANN ONCOL, V18, P768, DOI 10.1093/annonc/mdl465
   Molassiotis A, 2013, HEALTH TECHNOL ASSES, V17, DOI 10.3310/hta17260
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Ni MX, 2024, PHYTOMEDICINE, V127, DOI 10.1016/j.phymed.2024.155496
   Oki E, 2015, INT J CLIN ONCOL, V20, P767, DOI 10.1007/s10147-015-0784-9
   Shah S., 2022, Common Terminology Criteria for Adverse Events, V784
   Sun LY, 2024, EUR J CANCER, V213, DOI 10.1016/j.ejca.2024.115109
   Takemura N, 2024, JAMA ONCOL, V10, P176, DOI 10.1001/jamaoncol.2023.5248
   Tilburt JC, 2008, B WORLD HEALTH ORGAN, V86, P594, DOI 10.2471/BLT.07.042820
   Viviana Cortlana Ms, 2025, Oncology (Williston Park), V39, P105, DOI 10.46883/2025.25921037
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
   Zhang YL, 2024, CHIN J INTEGR MED, V30, P963, DOI 10.1007/s11655-024-4114-9
   Zick SM, 2016, JAMA ONCOL, V2, P1470, DOI 10.1001/jamaoncol.2016.1867
NR 42
TC 0
Z9 0
U1 4
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD NOV 15
PY 2025
VL 131
IS 22
AR e70170
DI 10.1002/cncr.70170
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 9YN2J
UT WOS:001618067800016
PM 41217297
DA 2026-01-16
ER

PT J
AU He, Z
   Xing, LW
   He, M
   Sun, YH
   Xu, JL
   Zhuang, HN
   Guo, R
   Chen, HX
   Wu, KN
   Dong, QZ
   Yin, GC
   Zhang, JB
   Yu, S
   Wang, XY
   Zhao, R
   Qin, DD
AF He, Zhe
   Xing, Liwei
   He, Ming
   Sun, Yuhuan
   Xu, Jinlong
   Zhuang, Haina
   Guo, Rui
   Chen, Hongxi
   Wu, Kenan
   Dong, Qinzuo
   Yin, Guochen
   Zhang, Junbao
   Yu, Shun
   Wang, Xiaoyan
   Zhao, Rong
   Qin, Dongdong
TI Best acupuncture method for mammary gland hyperplasia: Evaluation of
   randomized controlled trials and Bayesian network meta-analysis
SO HELIYON
LA English
DT Article
DE Acupuncture; Mammary gland hyperplasia; Network meta -analysis;
   Effectiveness
ID BENIGN BREAST DISEASE; CANCER RISK; DIAGNOSIS; PAIN
AB Objective: To evaluate the effectiveness of different acupuncture treatments for mammary gland hyperplasia (MGH) using a network meta -analysis. Methods: Several databases were searched without language restrictions from 2000 to February 2023, including PubMed, Embase, Web of Science, Cochrane Library, China Science and Technology Journal Database, China Biology Medicine Database, Wanfang Database, China National Knowledge Infrastructure Database, and other professional websites and gray literature. Inclusion criteria were adult women diagnosed with MGH; intervention measures included acupuncture and related therapies; the control group was treated with simple drugs; and the research type was a randomized controlled trial (RCT). The primary outcomes were treatment effectiveness and estradiol and progesterone levels. Secondary outcomes were breast lump size and visual analog scale (VAS) score of breast pain. Exclusion criteria were studies unrelated to MGH, incorrect study populations, control measures or interventions, incomplete data, non-RCTs, case reports, and animal experiments. Cochrane tools were used to assess the risk of bias. The R software (x64 version 4.2.1), Review Manager 5.3 software and STATA 16.0 software were used for data analysis. Results: Following a rigorous screening process, data extraction, and quality assessment, 48 eligible RCTs encompassing 4,500 patients with MGH and 16 interventions were included. The results indicated that acupuncture, alone or in combination with traditional Chinese or Western medicine, had better therapeutic effects than conventional therapy. In terms of effectiveness, warm needle acupuncture was the best choice (94.6%). Bloodletting pricking was the most effective method (85.7%) for lowering progesterone levels. Bloodletting pricking was the most effective method (98.3%) for lowering estradiol levels. Manual acupuncture combined with traditional Chinese medicine was the most effective (74.5%) treatment to improve the size of the breast lump. Warm needle acupuncture was the most effective (69.8%) in improving the VAS score. Conclusion: Acupuncture therapy was more effective in treating MGH than drug therapy alone, and warm needle acupuncture and bloodletting pricking were the two best options. However, larger sample sizes and high -quality RCTs are required.
C1 [He, Zhe; He, Ming; Sun, Yuhuan; Zhuang, Haina; Wu, Kenan; Yin, Guochen; Zhang, Junbao; Yu, Shun] Yunnan Univ Chinese Med, Sch Clin Med 2, 1076 Yuhua Rd, Kunming 650500, Peoples R China.
   [Xing, Liwei; Xu, Jinlong; Guo, Rui; Dong, Qinzuo; Zhao, Rong] Yunnan Univ Chinese Med, Sch Clin Med 1, 1076 Yuhua Rd, Kunming 650500, Peoples R China.
   [Wang, Xiaoyan] Yuxi Tradit Chinese Med Hosp, Dept Acupuncture & Moxibust, 53 North Nie er Rd, Yuxi 653100, Peoples R China.
   [Chen, Hongxi; Qin, Dongdong] Yunnan Univ Chinese Med, Sch Basic Med Sci, 1076 Yuhua Rd, Kunming 650500, Peoples R China.
C3 Yunnan University of Chinese Medicine; Yunnan University of Chinese
   Medicine; Yunnan University of Chinese Medicine
RP Zhao, R (corresponding author), Yunnan Univ Chinese Med, Sch Clin Med 1, 1076 Yuhua Rd, Kunming 650500, Peoples R China.; Wang, XY (corresponding author), Yuxi Tradit Chinese Med Hosp, Dept Acupuncture & Moxibust, 53 North Nie er Rd, Yuxi 653100, Peoples R China.; Qin, DD (corresponding author), Yunnan Univ Chinese Med, Sch Basic Med Sci, 1076 Yuhua Rd, Kunming 650500, Peoples R China.
EM xyw413@126.com; zhaorongkm@163.com; qindong108@163.com
RI 秦, 冬/GQA-7638-2022
FU Talent Program of Yunnan Province [YNWR-QNBJ-2019-235]
FX We thank the authors of published clinical studies on acupuncture
   treatment for MGH for providing the primary data. This study was
   supported by the National Natural Science Foundation of China (81760896,
   82160923, 82374425) ; Applied Basic Research Programs of Science and
   Technology Commission Foundation of Yunnan Province (202301AS070053) ;
   Key Laboratory of Traditional Chinese Medicine for Prevention and
   Treatment of Neuropsychiatric Diseases, Yunnan Provincial Department of
   Education; Scientific Research Projects for High-level Talents of Yunnan
   University of Chinese Medicine (2019YZG01) ; Young Top-Notch Talent in
   10,000 Talent Program of Yunnan Province (YNWR-QNBJ-2019-235) . We
   sincerely appreciate the contributions of all authors who included the
   original study.r Talent Program of Yunnan Province (YNWR-QNBJ-2019-235)
   . We sincerely appreciate the contributions of all authors who included
   the original study.
CR Ashad-Bishop K, 2019, BIOCHEM BIOPH RES CO, V508, P536, DOI 10.1016/j.bbrc.2018.11.155
   Brem RF, 2020, RADIOLOGY, V294, P87, DOI 10.1148/radiol.2019192192
   Chen CC, 2015, CELL BIOCHEM BIOPHYS, V71, P1663, DOI 10.1007/s12013-014-0388-4
   Chen H.G., 2011, Zhejiang J. Tradit. Chin. Med., V46, P406
   Chen Q.L., 2020, Med Innovation China, V17, P84
   Chen S.Y., 2020, Reflexo. Rehabilit. Med., V29, P73, DOI [10.19589/j.cnki.issn2096-7950.2020.12.073, DOI 10.19589/J.CNKI.ISSN2096-7950.2020.12.073]
   Chen X., 2019, Yunnan J Tradit Chin Med., V42, P59, DOI [10.19288/j.cnki.issn.1000-2723.2019.06.010, DOI 10.19288/J.CNKI.ISSN.1000-2723.2019.06.010]
   Chen Y, 2023, FRONT NEUROL, V14, DOI 10.3389/fneur.2023.1093849
   Degnim AC, 2007, J CLIN ONCOL, V25, P2671, DOI 10.1200/JCO.2006.09.0217
   Dong W.Q., 2019, Heilongjiang Med J., V32, P1084, DOI [10.14035/j.cnki.hljyy.2019.05.037, DOI 10.14035/J.CNKI.HLJYY.2019.05.037]
   Du Y.M., 2020, Liaoning J. Tradit. Chin. Med., V22, P174, DOI [10.13194/j.issn.1673-842x.2020.01.047, DOI 10.13194/J.ISSN.1673-842X.2020.01.047]
   Dyrstad SW, 2015, BREAST CANCER RES TR, V149, P569, DOI 10.1007/s10549-014-3254-6
   Fan Y.-H., 2018, Network Meta-Analysis of Acupuncture Treatment for Mammary Gland Hyperplasia, V1, P19
   Feng C., 2021, Res. Integr. Tradit. West Med., V13
   Fu Y.W., 2021, Nei Mongol J Tradit Chin Med., V40, P94, DOI [10.16040/j.cnki.cn15-1101.2021.04.056, DOI 10.16040/J.CNKI.CN15-1101.2021.04.056]
   Gao H.L., 2023, Chin J of PHM, V39, P243, DOI [10.19568/j.cnki.23-1318.2023.02.0026, DOI 10.19568/J.CNKI.23-1318.2023.02.0026]
   Gao R.R., 2020, Sichuan J Tradit Chin Med., V38, P167
   GATELEY CA, 1992, J ROY SOC MED, V85, P12
   Ge L, 2022, CHIN MED-UK, V17, DOI 10.1186/s13020-021-00558-4
   Guan Qing-Xia, 2023, Zhongguo Zhong Yao Za Zhi, V48, P2856, DOI 10.19540/j.cnki.cjcmm.20230315.601
   Guo C, 1996, J Tradit Chin Med, V16, P281
   Guray M, 2006, ONCOLOGIST, V11, P435, DOI 10.1634/theoncologist.11-5-435
   Hartmann LC, 2005, NEW ENGL J MED, V353, P229, DOI 10.1056/NEJMoa044383
   He H.Y., 2021, Sichuan J. Tradit. Chin. Med., V39, P144
   He W., 2020, Matern Child Health Care China, V35, P2974, DOI [10.19829/j.zgfybj.issn.1001-4411.2020.16.013, DOI 10.19829/J.ZGFYBJ.ISSN.1001-4411.2020.16.013]
   Huang F.Q., 2014, Hubei J. Tradit. Chin. Med., V36, P6
   Huo Y.D., 2015, Sichuan J Tradit Chin Med., V33, P155
   Jiang MY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20112620
   Jin J.J., 2020, Jiangsu J Tradit Chin Med., V52, P73, DOI [10.19844/j.cnki.1672-397X.2020.11.025, DOI 10.19844/J.CNKI.1672-397X.2020.11.025]
   Kang R.G., 2021, Mod J Integr Tradit Chin West Med., V30, P523
   Ke R.Q., 2016, Guid J Tradit Chin Med Pharm., V22, P68, DOI [10.13862/j.cnki.cn43-1446/r.2016.15.023, DOI 10.13862/J.CNKI.CN43-1446/R.2016.15.023]
   Kilgore LJ, 2022, ANN SURG, V276, pE932, DOI 10.1097/SLA.0000000000004849
   Kim H, 2009, BRAIN RES BULL, V78, P164, DOI 10.1016/j.brainresbull.2008.10.006
   Kvist LJ, 2007, MIDWIFERY, V23, P184, DOI 10.1016/j.midw.2006.02.003
   Li H., 2020, Chin J Clin Res., V12, P100
   Li RL, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000023521
   Li XL, 2017, AM J CHINESE MED, V45, P443, DOI 10.1142/S0192415X17500276
   Li Y.B., 2015, Mod. Diagn. Treat., V26, P2417
   Lin N.Q., 2022, Chin NA Med Res., V20, P42, DOI [10.14033/j.cnki.cfmr.2022.13.012, DOI 10.14033/J.CNKI.CFMR.2022.13.012]
   Liu S.P., 2014, Med. Aesthetol. Cosmetol., P237
   [刘胜 Liu Sheng], 2023, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V38, P1159
   Liu T.M., 2022, Ningxia Med. J., V44, P269, DOI [10.13621/j.1001-5949.2022.03.0269, DOI 10.13621/J.1001-5949.2022.03.0269]
   Lu J.L., 2019, Sichuan J. Tradit. Chin. Med., V37, P192
   Lv Z, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.921119
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Ma W, 2021, CHINESE MED J-PEKING, V134, P1891, DOI 10.1097/CM9.0000000000001521
   Ma Z.L., 2022, Guangming Tradit. Chin. Med., V37, P654
   MacPherson H, 2010, ACUPUNCT MED, V28, P83, DOI 10.1136/aim.2009.001370
   MANSEL RE, 1990, LANCET, V335, P190, DOI 10.1016/0140-6736(90)90278-D
   McCann H., 2014, Pricking the Vessels: Bloodletting Therapy in Chinese Medicine
   Morrow M, 2015, NAT REV CLIN ONCOL, V12, P227, DOI 10.1038/nrclinonc.2015.8
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n160, 10.1136/bmj.n71, 10.1038/nchembio.2180, 10.1186/s40900-023-00424-7, 10.3390/jpm13020373]
   [潘佳慧 Pan Jiahui], 2022, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V37, P1213
   Qian C.Y., 2021, J Shanghai Acup Moxib, V40, P982, DOI [10.13460/j.issn.1005-0957.2021.08.0982, DOI 10.13460/J.ISSN.1005-0957.2021.08.0982]
   Qiu L.H., 2022, Chin Manip Rehab Med., V13, P9, DOI [10.19787/j.issn.1008-1879.2022.14.004, DOI 10.19787/J.ISSN.1008-1879.2022.14.004]
   Ryu KJ, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.43951
   Schulz KF, 2010, J PHARMACOL PHARMACO, V1, P100, DOI 10.4103/0976-500X.72352
   Shen L.M., 2011, Shandong J. Tradit. Chin. Med., V30, P859, DOI [10.16295/j.cnki.0257-358x.2011.12.002, DOI 10.16295/J.CNKI.0257-358X.2011.12.002]
   Silvera SAN, 2008, BREAST CANCER RES TR, V110, P397, DOI 10.1007/s10549-007-9740-3
   Sun Y.X., 2021, Mod J Integr Tradit Chin West Med., V30, P856
   Tan J., 2021, Hebei J Tradit Chin Med., V43, P653
   Tong QY, 2022, CLIN BREAST CANCER, V22, P724, DOI 10.1016/j.clbc.2022.04.010
   Vegunta S, 2023, CLEV CLIN J MED, V90, P423, DOI 10.3949/ccjm.90a.22098
   Wang F., 2017, Lishizhen Med. Mater. Med. Res., V28, P2161
   Wang M, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1147718
   Wang W.Q., 2021, Tradit. Chin. Med. Doctor., V6, P78
   Wang Y.H., 2020, Elec. J. Pract. Gynec. Endocrin., V7, P59, DOI [10.16484/j.cnki.issn2095-8803.2020.20.038, DOI 10.16484/J.CNKI.ISSN2095-8803.2020.20.038]
   Wang YF, 2018, J ACUPUNCT TUINA SCI, V16, P189, DOI 10.1007/s11726-018-1049-8
   Wang Z.Y., 2020, Guid J Tradit Chin Med Pharm., V26, P86, DOI [10.13862/j.cnki.cn43-1446/r.2020.02.024, DOI 10.13862/J.CNKI.CN43-1446/R.2020.02.024]
   Wen Y.H., 2019, Sichuan J Tradit Chin Med., V37, P204
   Williamson A, 2005, J CLIN NURS, V14, P798, DOI 10.1111/j.1365-2702.2005.01121.x
   Xiong W., 2012, Hunan J Tradit Chin Med., V28, P8, DOI [10.16808/j.cnki.issn1003-7705.2012.01.004, DOI 10.16808/J.CNKI.ISSN1003-7705.2012.01.004]
   Yan L.J., 2019, Matern. Child Health Care China, V34, P200
   Yan Z.H., 2021, J. Shanghai Acup. Moxib., V40, P184, DOI [10.13460/j.issn.1005-0957.2021.02.0184, DOI 10.13460/J.ISSN.1005-0957.2021.02.0184]
   Yan Z.H., 2019, Chin. J. Misdiagn., V14, P216
   Yang F.C., 2021, J. Shanghai Acup. Moxib., V40, P709, DOI [10.13460/j.issn.1005-0957.2021.06.0709, DOI 10.13460/J.ISSN.1005-0957.2021.06.0709]
   Yang Ji-Jun, 2012, Zhen Ci Yan Jiu, V37, P173
   Yang L, 2018, INT J NURS STUD, V82, P129, DOI 10.1016/j.ijnurstu.2018.03.013
   Yang R.X., 2017, Mod J Integr Tradit Chin West Med., V26, P1214
   Yang XJ, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e21000
   Ye Z, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e15291
   Yu WL, 2023, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.1086195
   Zeng J.G., 2011, J Shanghai Acup Moxib., V30, P821
   Zhang Li-Jen, 2008, Zhongguo Zhen Jiu, V28, P648
   Zhang W.H., 2019, J. Shanghai Acup. Moxib., V38, P1355, DOI [10.13460/j.issn.1005-0957.2019.12.1355, DOI 10.13460/J.ISSN.1005-0957.2019.12.1355]
   Zhang X.N., 2021, China's Naturopathy, V29, P43, DOI [10.19621/j.cnki.11-3555/r.2021.0317, DOI 10.19621/J.CNKI.11-3555/R.2021.0317]
   Zhang Y.F., 2022, New Chin. Med., V54, P157, DOI [10.13457/j.cnki.jncm.2022.02.041, DOI 10.13457/J.CNKI.JNCM.2022.02.041]
   Zhao Xian, 2018, Zhen Ci Yan Jiu, V43, P645, DOI 10.13702/j.1000-0607.170117
   Zhao Xian, 2017, Zhongguo Zhen Jiu, V37, P1309, DOI 10.13703/j.0255-2930.2017.12.015
   Zheng F.R., 2008, J. Shanghai Acup. Moxib., V06, P13, DOI [10.13460/j.issn.1005-0957.2008.06.026, DOI 10.13460/J.ISSN.1005-0957.2008.06.026]
   Zhou Lei, 2011, Zhen Ci Yan Jiu, V36, P52
   Zhou M.L., 2014, AsiaPacific Tradit. Med., V10, P80
   Zhou X.M., 2019, J Qilu Nurs., V25, P111
NR 93
TC 0
Z9 0
U1 2
U2 16
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD APR 30
PY 2024
VL 10
IS 8
AR e28831
DI 10.1016/j.heliyon.2024.e28831
EA APR 2024
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SD7S1
UT WOS:001232591400001
PM 38638998
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Hao, J
   Zhu, XS
   Bensoussan, A
AF Hao, Jie
   Zhu, Xiaoshu
   Bensoussan, Alan
TI Effects of Nonpharmacological Interventions in Chemotherapy-Induced
   Peripheral Neuropathy: An Overview of Systematic Reviews and
   Meta-Analyses
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE overview; systematic review; meta-analysis; nonpharmacological
   intervention; chemotherapy-induced peripheral neuropathy
ID DOUBLE-BLIND; VITAMIN-E; ELECTROACUPUNCTURE; MANAGEMENT; COMPLEMENTARY;
   BALANCE; PAIN; GABAPENTIN; EXPRESSION; PREVENTION
AB Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the prevalent and disabling side effects of cancer treatment. However, management strategies for CIPN currently remain elusive, with treatment restricted to neuropathic pain medications, supportive care, and chemotherapy dosing adjustments. This overview explores evidence on the potential benefits and safety of nonpharmacological interventions in preventing and treating CIPN in cancer patients. Methods: Seven databases were searched for systematic reviews of randomized controlled trials (RCTs). The methodological quality of the selected reviews was assessed by AMSTAR 2, and the quality of evidence was judged by GRADE. Twenty-eight systematic reviews were considered eligible for this review. Results: It was found that nonpharmacological interventions (acupuncture, exercise, herbal medicine, nutritional supplements) provided potential benefits for patients with CIPN. Furthermore, Chinese herbal medicine, administered orally or externally, significantly prevented and/or relieved the incidence and severity of CIPN in comparison to control groups (no additional treatment, placebo, and conventional western medicine). However, the quality of evidence and strength of recommendations were compromised by the inconsistencies and imprecision of included studies. The main concerns regarding the quality of systematic reviews included the lack of sufficiently rigorous a priori protocols, and the lack of protocol registration adopted in the included studies. Conclusions: Though looking across reviews, Chinese herbal medicine appear generally effective in CIPN, uncertainty remains about the effects of many other nonpharmacological interventions. The evidence on what works was particularly compromised by reporting and methodological limitations, which requires further investigation to be more certain of their effects.
C1 [Hao, Jie; Zhu, Xiaoshu; Bensoussan, Alan] Western Sydney Univ, Sydney, NSW, Australia.
C3 Western Sydney University
RP Zhu, XS (corresponding author), Western Sydney Univ, Locked Bag 1797, Penrith, NSW 2751, Australia.
EM xiaoshuzhuwesternsydney@gmail.com
RI ; Zhu, Xiaoshu/NRX-7991-2025
OI Hao, Jie/0000-0003-3450-9254; Zhu, Xiaoshu/0000-0002-2909-5926
FU Western Sydney University Research Training Scheme [UWS18405473]; China
   Scholarship Council Higher Degree (Doctor of Philosophy) Program
   [CSC201506550006]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was funded by the Western Sydney University Research Training Scheme
   (Grant Number UWS18405473); China Scholarship Council Higher Degree
   (Doctor of Philosophy) Program (Grant Number CSC201506550006).
CR [Anonymous], 2010, SURGERY, DOI DOI 10.1016/J.SURG.2009.06.030
   [Anonymous], 2015, MOD J INTEGR TRADIT
   [Anonymous], 2008, J JIANGXI U TRADITIO
   [Anonymous], 2003, STRENGTH POWER SPORT
   Argyriou AA, 2017, NAT REV NEUROL, V13, P492, DOI 10.1038/nrneurol.2017.88
   Ben-Arye E, 2012, SUPPORT CARE CANCER, V20, P557, DOI 10.1007/s00520-011-1121-0
   Brami C, 2016, CRIT REV ONCOL HEMAT, V98, P325, DOI 10.1016/j.critrevonc.2015.11.014
   Brayall P, 2018, REHABIL ONCOL, V36, P161, DOI 10.1097/01.REO.0000000000000111
   Chen S., 2018, THESIS
   Cheng XL, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00344
   Coste TC, 2003, DIABETES, V52, P2578, DOI 10.2337/diabetes.52.10.2578
   Deng B, 2016, CHIN ARCH TRADIT CHI, V34, P20, DOI [10.13193/j.issn.1673-7717.2016.01.005, DOI 10.13193/J.ISSN.1673-7717.2016.01.005]
   Deng B, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/2421876
   Derksen TME, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/7916031
   Duregon F, 2018, CRIT REV ONCOL HEMAT, V121, P90, DOI 10.1016/j.critrevonc.2017.11.002
   Eum S, 2013, INT J VITAM NUTR RES, V83, P101, DOI 10.1024/0300-9831/a000149
   Franconi G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/516916
   Fusumada Kazutoshi, 2007, Okajimas Folia Anatomica Japonica, V84, P1, DOI 10.2535/ofaj.84.1
   Gerbi A, 1999, J NUTR, V129, P207, DOI 10.1093/jn/129.1.207
   Gewandter JS, 2017, NEUROLOGY, V89, P859, DOI 10.1212/WNL.0000000000004272
   Gladman SJ, 2012, J NEUROSCI, V32, P563, DOI 10.1523/JNEUROSCI.3371-11.2012
   He B, 2013, J LIAONING U TRADIT, V15, P146, DOI [10.13194/j.jlunivtcm.2013.06.148.heb.055, DOI 10.13194/J.JLUNIVTCM.2013.06.148.HEB.055]
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Hoshino N, 2018, INT J CLIN ONCOL, V23, P434, DOI 10.1007/s10147-017-1229-4
   Hsiang SW, 2011, AM J CHINESE MED, V39, P1207, DOI 10.1142/S0192415X11009500
   Huang HP, 2016, WSPOLCZESNA ONKOL, V20, P237, DOI 10.5114/wo.2016.61567
   Huang KS, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nep115
   Hunter J, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2209-6
   Ji Y., 2016, THESIS
   Kautio AL, 2008, J PAIN SYMPTOM MANAG, V35, P31, DOI 10.1016/j.jpainsymman.2007.02.043
   Kim B. J., 1997, International Journal of Cosmetic Science, V19, P299, DOI 10.1046/j.1467-2494.1997.171726.x
   Kuriyama A, 2018, SUPPORT CARE CANCER, V26, P1051, DOI 10.1007/s00520-017-4028-6
   Li K, 2019, CURR ONCOL, V26, pE147, DOI 10.3747/co.26.4261
   Li Q, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/2346583
   Liberati Alessandro, 2009, PLoS Med, V6, pe1000100, DOI 10.1371/journal.pmed.1000100
   Liu YW, 2010, BIOCHEM BIOPH RES CO, V399, P49, DOI 10.1016/j.bbrc.2010.07.037
   Liu YH, 2018, INTEGR CANCER THER, V18, DOI 10.1177/1534735418817833
   Mannelli LD, 2017, SCI REP-UK, V7, DOI 10.1038/srep42021
   Mannelli LDC, 2015, PLANTA MED, V81, P1045, DOI 10.1055/s-0035-1546117
   Manni L, 2011, DIABETOLOGIA, V54, P1900, DOI 10.1007/s00125-011-2117-5
   Mao Z., 2017, Modern Chin Western Med, V26, P4027, DOI [10.3969/j.issn.1008-8849.2017.36.011, DOI 10.3969/J.ISSN.1008-8849.2017.36.011]
   MILLER AB, 1981, CANCER, V47, P207, DOI 10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6
   NIWA Y, 1986, INFLAMMATION, V10, P79, DOI 10.1007/BF00916043
   Noh H, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/6194184
   Oh PJ, 2018, J KOREAN ACAD NURS, V48, P123, DOI 10.4040/jkan.2018.48.2.123
   Öztürk G, 2004, TOXICOL APPL PHARM, V196, P169, DOI 10.1016/j.taap.2003.12.006
   Pachman DR, 2014, CURR TREAT OPTION ON, V15, P567, DOI 10.1007/s11864-014-0303-7
   Park JH, 2010, BRAIN RES, V1322, P24, DOI 10.1016/j.brainres.2010.02.001
   Rao RD, 2008, CANCER, V112, P2802, DOI 10.1002/cncr.23482
   Rao RD, 2007, CANCER-AM CANCER SOC, V110, P2110, DOI 10.1002/cncr.23008
   Robson LG, 2010, NEUROBIOL AGING, V31, P678, DOI 10.1016/j.neurobiolaging.2008.05.027
   Rossi E, 2018, J ALTERN COMPLEM MED, V24, P933, DOI 10.1089/acm.2018.0143
   Schloss JM, 2013, CLIN NUTR, V32, P888, DOI 10.1016/j.clnu.2013.04.007
   SCHRODER S, 2013, EVID-BASED COMPL ALT, V2013, DOI DOI 10.1155/2013/423713
   Schunemann H, GRADE handbook: handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Shalom-Sharabi I, 2017, J CANCER RES CLIN, V143, P2535, DOI 10.1007/s00432-017-2509-0
   Shea BJ, 2017, BMJ-BRIT MED J, V358, DOI 10.1136/bmj.j4008
   Shi Y, 2015, MANUAL CLIN ONCOLOGY, V6th
   Silva JRT, 2011, J PAIN, V12, P51, DOI 10.1016/j.jpain.2010.04.008
   Staff NP, 2017, ANN NEUROL, V81, P772, DOI 10.1002/ana.24951
   Streckmann F, 2014, SPORTS MED, V44, P1289, DOI 10.1007/s40279-014-0207-5
   Sung HJ, 2004, PROTEOMICS, V4, P2805, DOI 10.1002/pmic.200300821
   Taube W, 2008, ACTA PHYSIOL, V193, P101, DOI 10.1111/j.1748-1716.2008.01850.x
   Taube W, 2007, ACTA PHYSIOL, V189, P347, DOI 10.1111/j.1748-1716.2007.01665.x
   Tian J, 2013, Chin J Exp Tradit Med Form, V19, P325, DOI DOI 10.11653/SYFJ2013220325
   Tsavaris N, 2008, PAIN MED, V9, P1209, DOI 10.1111/j.1526-4637.2007.00325.x
   Vickers A, 1998, CONTROL CLIN TRIALS, V19, P159, DOI 10.1016/S0197-2456(97)00150-5
   Wang QY, 2015, MOD DIGESTION INTERV, V20, P387
   Wei XC, 2016, SHANDONG MED J, V56, P77
   [魏晓晨 Wei Xiaochen], 2016, [中国实验方剂学杂志, Chinese Journal of Experimental Traditional Medical Formulae], V22, P186
   [魏晓晨 Wei Xiaochen], 2016, [中国现代应用药学, Chinese Journal of Modern Applied Pharmacy], V33, P476
   Xing GG, 2007, EXP NEUROL, V208, P323, DOI 10.1016/j.expneurol.2007.09.004
   Yan Y, 2018, Jiangxi Tradit Chin Med, V49, P61
   Yang LN, 2018, J BASIC CHIN MED, V24, P1101
   Yee P, 2010, INVEST OPHTH VIS SCI, V51, P1755, DOI 10.1167/iovs.09-3792
   Zhang AC, 2020, NUTR REV, V78, P323, DOI 10.1093/nutrit/nuz054
NR 77
TC 16
Z9 18
U1 2
U2 16
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD SEP
PY 2020
VL 19
AR 1534735420945027
DI 10.1177/1534735420945027
PG 23
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA NM2FC
UT WOS:000567916900001
PM 32875921
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Espinosa, MVG
   Vila, SFG
   de Paul, MF
   Carrero, PM
   Checa, IP
   Enríquez, GI
AF Espinosa, Maria Victoria Garcia
   Vila, Silvia Fernanda Garcia
   de Paul, Maria Fernandez
   Carrero, Patricia Moreno
   Checa, Isabel Prieto
   Enriquez, Gema Izquierdo
TI Unhelpful believes about pain. Brief pain advice in primary care
SO ATENCION PRIMARIA
LA English
DT Article
DE Chronic pain; Treatment; Brief advice; Primary care
AB In chronic non-oncological pain, there is a gap between the recommendations and the usual clinical practice. To improve this situation, it is essential to address unhelpful beliefs about pain in patients and health professionals. We address cultural beliefs such as thinking that pain means damage to the tissue where it is felt, that pain originates in the area where it is perceived, that it is important to rest for the tissues to heal, or that drugs and surgery are the best treatments for pain. First, professionals need to reflect on their own beliefs , question their own clinical practice: what do I believe about pain? Are these beliefs in line with current evidence? Do I follow the recommendations of clinical practice guidelines? In this way, by aligning their beliefs with the evidence, professionals will be able to begin to give appropriate educational advice to patients. (c) 2024 The Authors. Published by Elsevier Espana, a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Espinosa, Maria Victoria Garcia; Checa, Isabel Prieto] Ctr Salud Alpes, Ctr Salud Condes Barcelona, Madrid, Spain.
   [Vila, Silvia Fernanda Garcia] Ctr Salud Buenos Aires, Madrid, Spain.
   [de Paul, Maria Fernandez] Ctr Salud Benita Avila, Gerencia Atenc Primaria, Madrid, Spain.
   [Carrero, Patricia Moreno] Ctr Salud Valleaguado, Gerencia, Madrid, Spain.
   [Enriquez, Gema Izquierdo] Ctr Salud Villa Vallecas, Gerencia Atenc Primaria, Madrid, Spain.
RP Espinosa, MVG (corresponding author), Ctr Salud Alpes, Ctr Salud Condes Barcelona, Madrid, Spain.
EM vgespinosa@gmail.com
OI Prieto Checa, Isabel/0000-0002-5254-7521
CR Aaij R, 2021, J HIGH ENERGY PHYS, DOI 10.1007/JHEP02(2021)023
   [Anonymous], 2021, NICE guideline NG193
   Birkinshaw H, 2023, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD014682
   Brinjikji W, 2015, AM J NEURORADIOL, V36, P811, DOI 10.3174/ajnr.A4173
   Buchbinder R, 2018, LANCET, V391, P2384, DOI 10.1016/S0140-6736(18)30488-4
   Caneiro JP, 2021, BRAZ J PHYS THER, V25, P17, DOI 10.1016/j.bjpt.2020.06.003
   Darlow B, 2012, EUR J PAIN, V16, P3, DOI 10.1016/j.ejpain.2011.06.006
   Derry S, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008609.pub2
   Foster NE, 2018, LANCET, V391, P2368, DOI 10.1016/S0140-6736(18)30489-6
   Hall A, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-10664-5
   Hartley C, 2020, J BONE MINER RES, V35, P53, DOI 10.1002/jbmr.3867
   Jacobs JC, 2020, J GEN INTERN MED, V35, P3605, DOI 10.1007/s11606-020-06181-7
   Jüni P, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005328.pub3
   Latremoliere A, 2009, J PAIN, V10, P895, DOI 10.1016/j.jpain.2009.06.012
   Machado GC, 2017, ANN RHEUM DIS, V76, P1269, DOI 10.1136/annrheumdis-2016-210597
   Machado GC, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.h1225
   Mannion AF, 2016, SPINE J, V16, P588, DOI 10.1016/j.spinee.2015.12.001
   Margarit C, 2019, REV SOC ESP DOLOR, V26, DOI 10.20986/resed.2019.3752/2019
   Mathieson S, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m1315
   Nury E, 2022, PAIN, V163, P610, DOI 10.1097/j.pain.0000000000002423
   O'Connor D, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD014328
   Rajasekaran S, 2021, EUR SPINE J, V30, P2069, DOI 10.1007/s00586-021-06809-0
   Sharma S, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2020-037820
   von Arx M, 2021, FRONT BIOENG BIOTECH, V9, DOI 10.3389/fbioe.2021.769117
NR 24
TC 2
Z9 2
U1 0
U2 1
PU EDICIONES DOYMA S A
PI BARCELONA
PA TRAV DE GRACIA 17-21, 08021 BARCELONA, SPAIN
SN 0212-6567
EI 1578-1275
J9 ATEN PRIM
JI Aten. Prim.
PD DEC
PY 2024
VL 56
IS 12
AR 103120
DI 10.1016/j.aprim.2024.103120
EA DEC 2024
PG 9
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA O6I1K
UT WOS:001372129400001
PM 39499987
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Simpson, CA
AF Simpson, Charles A.
TI Complementary Medicine in Chronic Pain Treatment
SO PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
LA English
DT Article
DE Complementary and alternative medicine; Chronic pain; Therapies;
   Evidence-based medicine
ID RANDOMIZED CONTROLLED-TRIALS; LOW-BACK-PAIN; ALTERNATIVE MEDICINE;
   SPINAL MANIPULATION; AYURVEDIC MEDICINE; FOLLOW-UP; ACUPUNCTURE;
   THERAPY; CANCER; RELIABILITY
AB This article discusses several issues related to therapies that are considered "complementary" or "alternative" to conventional medicine. A definition of "complementary and alternative medicine" (CAM) is considered in the context of the evolving health care field of complementary medicine. A rationale for pain physicians and clinicians to understand these treatments of chronic pain is presented. The challenges of an evidence-based approach to incorporating CAM therapies are explored. Finally, a brief survey of the evidence that supports several widely available and commonly used complementary therapies for chronic pain is provided.
C1 [Simpson, Charles A.] CHP Grp, Clin Affairs, Beaverton, OR USA.
RP Simpson, CA (corresponding author), 3990 Southwest Lafollett Rd, Cornelius, OR 97113 USA.
EM casimpsondc@gmail.com
CR AARP NCCAM, 2010, COMPL ALT MED WHAT P
   Adams J, 2013, HEADACHE, V53, P459, DOI 10.1111/j.1526-4610.2012.02271.x
   Al-Shenqiti AM, 2005, CLIN REHABIL, V19, P482, DOI 10.1191/0269215505cr791oa
   American Chiropractic Association, ACA TOD
   [Anonymous], 1997, NIH Consens Statement, V15, P1
   [Anonymous], COMPL ALT INT HLTH W
   [Anonymous], COCHRANE DATABASE SY, DOI DOI 10.1002/14651858.CD002766
   Astin JA, 1998, JAMA-J AM MED ASSOC, V279, P1548, DOI 10.1001/jama.279.19.1548
   Barnes PM., 2008, NATL HLTH STAT REPOR, DOI DOI 10.1037/E623942009-001
   Bernstein BJ, 2001, ONCOLOGY-NY, V15, P1267
   Bernstein BJ, 2001, ONCOLOGY WILLISTON P, V15, P1283
   Bishop FL, 2010, J ALTERN COMPLEM MED, V16, P175, DOI 10.1089/acm.2009.0292
   Bledsoe Bryan E, 2004, J Am Osteopath Assoc, V104, P405
   Braverman D L, 1999, Phys Med Rehabil Clin N Am, V10, P631
   Braverman DL., 1999, Physical medicine and rehabilitation clinics of North America, V10, pix
   Breivik H, 2006, EUR J PAIN, V10, P287, DOI 10.1016/j.ejpain.2005.06.009
   Bronfort G, 2003, J AM CHIRO, V40, P42
   Brunelli B, 2004, J NEUROL SCI, V218, P59, DOI 10.1016/j.jns.2003.10.013
   Carter R, 2002, J FAM PRACTICE, V51, P38
   Chaitow L., 2004, J Osteop Med, V7, P33, DOI DOI 10.1016/S1443-8461(04)80007-8
   Chopra A, 2002, MED CLIN N AM, V86, P75, DOI 10.1016/S0025-7125(03)00073-7
   Chou R, 2007, NONPHARMACOLOGIC THE
   Chow RT, 2005, LASER SURG MED, V37, P46, DOI 10.1002/lsm.20193
   Chu Dennis A, 2004, Phys Med Rehabil Clin N Am, V15, P773, DOI 10.1016/j.pmr.2004.02.001
   Cicerone KD, 2005, ARCH PHYS MED REHAB, V86, P1073, DOI 10.1016/j.apmr.2005.01.003
   Coffelt TA, 2013, PEDIATRICS, V132, pE422, DOI 10.1542/peds.2012-1739
   Committee on Advancing Pain Research Care and Education, 2011, REL PAIN AM
   Consumer Reports.org, REL YOUR ACH BACK WH
   Curtis D, 2010, J BODYW MOV THER, V14, P272, DOI 10.1016/j.jbmt.2010.01.009
   Dagenais Simon, 2005, Spine J, V5, P310, DOI 10.1016/j.spinee.2004.09.011
   Deyo RA, 2014, J PAIN, V15, P569, DOI 10.1016/j.jpain.2014.03.005
   Deyo RA, 2009, J AM BOARD FAM MED, V22, P62, DOI 10.3122/jabfm.2009.01.080102
   DiNucci EM, 2005, ORTHOP NURS, V24, P259
   Eisenberg D, 1993, NEW ENGL J MED, V328, P426
   Eisenberg DM, 1998, JAMA-J AM MED ASSOC, V280, P1569, DOI 10.1001/jama.280.18.1569
   Ernst E, 1998, CANCER-AM CANCER SOC, V83, P777, DOI 10.1002/(SICI)1097-0142(19980815)83:4<777::AID-CNCR22>3.0.CO;2-O
   Farrar JT, 2001, PAIN, V94, P149, DOI 10.1016/S0304-3959(01)00349-9
   Fleming Sara, 2007, BMC Complement Altern Med, V7, P15, DOI 10.1186/1472-6882-7-15
   Fu LM, 2009, J ALTERN COMPLEM MED, V15, P133, DOI 10.1089/acm.2008.0135
   Gagnier Joel., 2011, HERBAL MED LOW BACK
   Green C, 1999, COMPLEMENT THER MED, V7, P199
   Gross A, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004249.pub3
   Haas M, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-16
   Healthcare Analysis & Information Group (HAIG), 2011, 2011 COMPL ALT MED
   Hirsh AT, 2005, CLIN J PAIN, V21, P302, DOI 10.1097/01.ajp.0000113057.92184.90
   Institute of Medicine (US) Committee on the Use of Complementary and Alternative Medicine by the American Public, 2005, COMPL ALT MED US, P8
   Jain Sanjiv, 2004, Phys Med Rehabil Clin N Am, V15, P811, DOI 10.1016/j.pmr.2004.04.005
   Jonas WB, 1999, ESSENTIALS COMPLEMEN, P210
   Kristoffersen ES, 2013, J HEADACHE PAIN, V14, DOI 10.1186/1129-2377-14-36
   Kumar S, 2013, INT J GEN MED, V6, P733, DOI 10.2147/IJGM.S50243
   Langevin HM, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1155/2011/180805
   Linde K, 2001, INT J EPIDEMIOL, V30, P526, DOI 10.1093/ije/30.3.526
   LUM LC, 1975, J PSYCHOSOM RES, V19, P375, DOI 10.1016/0022-3999(75)90017-3
   Lundgren Justin, 2004, Phys Med Rehabil Clin N Am, V15, P955, DOI 10.1016/j.pmr.2004.04.003
   Manheimer E, 2005, ANN INTERN MED, V142, P651, DOI 10.7326/0003-4819-142-8-200504190-00014
   McCrory D., 2001, Evidence report: Behavioral and physical treatments for tension-type and cervicogenic headache
   McMakin C, 1998, TOPICS CLIN CHIRO, V5, P29
   McMakin C, 2004, J BODYW MOV THER, V8, P143, DOI DOI 10.1016/j.jbmt.2003.12.006
   McMakin CR, 2005, J BODYW MOV THER, V9, P169, DOI 10.1016/j.jbmt.2004.12.003
   McPartland John M., 2004, Journal of the American Osteopathic Association, V104, P244
   Mehling WE, 2005, ALTERN THER HEALTH M, V11, P44, DOI 10.1111/j.1365-263X.2005.00605.x
   Molassiotis A, 2005, ANN ONCOL, V16, P655, DOI 10.1093/annonc/mdi110
   Moran RW, 2001, J MANIP PHYSIOL THER, V24, P183
   Muller R, 2005, J MANIP PHYSIOL THER, V28, P3, DOI 10.1016/j.jmpt.2004.12.004
   NIH National Cancer Institute, 2014, NIH PUBLICATION, V14-6287
   O'Connell NE, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008208.pub3
   Oschman J., 2003, Energy medicine in therapeutics and human performance
   Park JB, 2005, SEMIN ARTHRITIS RHEU, V34, P705, DOI 10.1016/j.semarthrit.2004.11.005
   Paterson C, 2005, BMJ-BRIT MED J, V330, P1202, DOI 10.1136/bmj.330.7501.1202
   Rosen JE, 2010, 14 INT THYR C PAR SE
   Rosenberg EI, 2008, PAIN MED, V9, P1065, DOI 10.1111/j.1526-4637.2008.00477.x
   Rubinstein SM, 2013, COCHRANE DB SYST REV
   Sawyer J, 1998, AORN J, V67, P674, DOI 10.1016/S0001-2092(06)62838-X
   Schutzler L, 2014, INTERNAL HLTH LOCUS
   Shekelle PG, 2005, ANN INTERN MED, V142, P1042, DOI 10.7326/0003-4819-142-12_Part_2-200506211-00003
   SHEKELLE PG, 1992, ANN INTERN MED, V117, P590, DOI 10.7326/0003-4819-117-7-590
   Simon D, 2007, COCHRANE DB SYST REV
   Sirois FM, 2008, BMC COMPLEM ALTERN M, V8, DOI 10.1186/1472-6882-8-16
   Starr P., 1982, SOCIAL TRANSFORMATIO
   SULLIVAN MD, 1993, J MED PHILOS, V18, P213, DOI 10.1093/jmp/18.2.213
   TRAVEL JG, 1983, MYOFASCIAL PAIN DYSF, V1
   Trigkilidas D, 2010, ANN ROY COLL SURG, V92, P595, DOI 10.1308/003588410X12699663904196
   Trinh K, 2007, SPINE, V32, P236, DOI 10.1097/01.brs.0000252100.61002.d4
   Weeks J, 2012, INTEGRATOR BLOG 0329
   Wells M, 2007, CANCER NURS, V30, P45, DOI 10.1097/00002820-200701000-00008
   Wells RE, 2011, HEADACHE, V51, P1087, DOI 10.1111/j.1526-4610.2011.01917.x
   Whitten Christine E, 2005, Perm J, V9, P41
   Wolsko PM, 2004, ALTERN THER HEALTH M, V10, P36
   Woodman JP, 2012, INT J CLIN PRACT, V66, P98, DOI 10.1111/j.1742-1241.2011.02817.x
   Ypusefi-Nooraie R, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005107.pub4
   Yuan J, 2008, SPINE, V33, pE887, DOI 10.1097/BRS.0b013e318186b276
NR 91
TC 7
Z9 10
U1 1
U2 27
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1047-9651
EI 1558-1381
J9 PHYS MED REH CLIN N
JI Phys. Med. Rehabil. Clin. N. Am.
PD MAY
PY 2015
VL 26
IS 2
BP 321
EP +
DI 10.1016/j.pmr.2014.12.005
PG 28
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA CJ3AV
UT WOS:000355356700013
PM 25952068
DA 2026-01-16
ER

PT J
AU Chen, H
   Fang, JF
   Liu, SX
   Gao, S
   Shi, HY
   Ma, JZ
   Shen, XY
   Wang, WM
   Liu, ZS
AF Chen, He
   Fang, Jiufei
   Liu, Sixing
   Gao, Shuai
   Shi, Hangyu
   Ma, Ji-Zheng
   Shen, Xinyu
   Wang, Weiming
   Liu, Zhishun
TI Efficacy and safety of two-step acupuncture therapy for symptom relief
   in adults with mild to moderate ulcerative colitis: rationale and design
   of the TSA-UC randomised controlled trial
SO BMJ OPEN
LA English
DT Article
DE Acupuncture; Inflammatory bowel disease; Randomized Controlled Trial
ID INFLAMMATORY-BOWEL-DISEASE; CLINICALLY MEANINGFUL IMPROVEMENT; RECTAL
   BLEEDING REMISSION; STOOL FREQUENCY REMISSION; EVIDENCE-BASED CONSENSUS;
   QUALITY-OF-LIFE; RELATIVE ASSOCIATION; COLORECTAL-CANCER; URGENCY
   REMISSION; QUESTIONNAIRE
AB Introduction Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterised by episodes of symptoms including rectal bleeding, increased stool frequency and abdominal pain, impacting quality of life significantly. Conventional treatments often come with potential side effects and may not be sufficient. Acupuncture is increasingly recognised for its potential benefits in UC. This study aims to assess the efficacy and safety of acupuncture for symptom relief in mild to moderate UC.Methods and analysis This single-centre, parallel-arm, randomised, sham-controlled, the two-step acupuncture (TSA)-UC trial, will involve 64 adults with mild to moderate UC, randomly assigned in a 1:1 ratio to either the acupuncture or sham acupuncture group. Participants will receive 20 sessions of two-step acupuncture or sham acupuncture therapy over 8 weeks. Blinding will be applied to participants, outcome assessors and statisticians. The primary outcome measure is the change in Patient-Reported Outcome 2 (PRO2) from baseline at week 8. Secondary outcomes include changes from baseline in the following scales: PRO2 at other time points, weekly average Numeric Rating Scale (NRS) for bowel urgency, weekly average NRS for abdominal pain (both associated and not associated with bowel movement), the 32-item Inflammatory Bowel Disease Questionnaire, Work Productivity and Activity Impairment Questionnaire-IBD, Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale. The Patient Global Impression of Change will also be assessed. Long-term effects of acupuncture will be explored. Adverse events and additional treatments will be monitored throughout the study. The modified intention-to-treat population including participants who complete baseline assessments and receive at least one treatment session will be analysed.Ethics and dissemination The study has received ethical approval from the Ethics Committee of Guang'anmen Hospital, China Academy of Chinese Medical Sciences (2024-190-KY). The results will be published in a peer-reviewed medical journal.Trial registration number NCT06615765.
C1 [Chen, He; Fang, Jiufei; Gao, Shuai; Wang, Weiming; Liu, Zhishun] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Acupuncture, Beijing, Peoples R China.
   [Liu, Sixing; Shen, Xinyu] Beijing Univ Chinese Med, Beijing, Peoples R China.
   [Shi, Hangyu] Westlake Univ, Sch Life Sci, Hangzhou, Zhejiang, Peoples R China.
   [Ma, Ji-Zheng] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Gastroenterol, Beijing, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Guang'anmen Hospital, CACMS;
   Beijing University of Chinese Medicine; Westlake University; Guang'anmen
   Hospital, CACMS; China Academy of Chinese Medical Sciences
RP Liu, ZS (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Acupuncture, Beijing, Peoples R China.
EM chenhenick@gmail.com; 1365623648@qq.com; sixingliu@sina.cn;
   gaoshuai980314@163.com; 18811735839@163.com; majizheng1116@yeah.net;
   shxinyu2001@163.com; wangweiming1a1@163.com; zhishunjournal@163.com
RI Shen, Xinyu/HZI-0909-2023
OI Chen, He/0000-0001-6681-2886; Liu, Sixing/0000-0002-6781-7600; Liu,
   Zhishun/0000-0001-7570-8917
FU High Level Chinese Medical Hospital Promotion Project [HLCMHPP2023089]
FX This study was funded by the High Level Chinese Medical Hospital
   Promotion Project (HLCMHPP2023089).
CR Achleitner U, 2012, J CROHNS COLITIS, V6, P507, DOI 10.1016/j.crohns.2011.11.003
   Alrubaiy L, 2015, J CROHNS COLITIS, V9, P284, DOI 10.1093/ecco-jcc/jjv002
   [Anonymous], 2024, R: A language and environment for statistical computing
   Armuzzi A, 2021, DIGEST LIVER DIS, V53, P803, DOI 10.1016/j.dld.2021.03.002
   Bang HJ, 2004, CONTROL CLIN TRIALS, V25, P143, DOI 10.1016/j.cct.2003.10.016
   Bao CH, 2022, ECLINICALMEDICINE, V45, DOI 10.1016/j.eclinm.2022.101300
   Bhala N, 2023, FRONTLINE GASTROENTE, V14, P25, DOI 10.1136/flgastro-2022-102104
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1002/smll.202408771
   Chan AW, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.e7586
   Chen XL, 2017, HEALTH QUAL LIFE OUT, V15, DOI 10.1186/s12955-017-0753-2
   D'Haens G, 2007, GASTROENTEROLOGY, V132, P763, DOI 10.1053/j.gastro.2006.12.038
   Danese S, 2023, INFLAMM BOWEL DIS, V29, P1723, DOI 10.1093/ibd/izad016
   Danese S, 2019, DIGEST DIS, V37, P266, DOI 10.1159/000496739
   De Simone B, 2021, WORLD J EMERG SURG, V16, DOI 10.1186/s13017-021-00362-3
   Devilly GJ, 2000, J BEHAV THER EXP PSY, V31, P73, DOI 10.1016/S0005-7916(00)00012-4
   Dignass A, 2012, J CROHNS COLITIS, V6, P965, DOI 10.1016/j.crohns.2012.09.003
   Dragasevic S, 2020, GASTROENT RES PRACT, V2020, DOI 10.1155/2020/2065383
   Dubinsky MC, 2022, CROHNS COLITIS 360, V4, DOI 10.1093/crocol/otac016
   Dubinsky MC, 2022, J PATIENT-REP OUTCOM, V6, DOI 10.1186/s41687-022-00439-w
   Fumery M, 2018, CLIN GASTROENTEROL H, V16, P343, DOI 10.1016/j.cgh.2017.06.016
   Greuter T, 2021, GUT, V70, P796, DOI 10.1136/gutjnl-2020-322129
   Gros B, 2023, JAMA-J AM MED ASSOC, V330, P951, DOI 10.1001/jama.2023.15389
   GUYATT G, 1989, GASTROENTEROLOGY, V96, P804, DOI 10.1016/0016-5085(89)90905-0
   Harbord M, 2016, J CROHNS COLITIS, V10, P239, DOI 10.1093/ecco-jcc/jjv213
   Horta D, 2020, INFLAMM BOWEL DIS, V26, P484, DOI 10.1093/ibd/izz091
   Jairath V, 2015, ALIMENT PHARM THER, V42, P1200, DOI 10.1111/apt.13408
   Jones Jennifer L, 2019, J Can Assoc Gastroenterol, V2, pS42, DOI [10.1093/jcag/gwy048, 10.1093/jcag/gwy048]
   Joos S, 2006, SCAND J GASTROENTERO, V41, P1056, DOI 10.1080/00365520600580688
   Kane SV, 2001, AM J GASTROENTEROL, V96, P2929
   Kaplan GG, 2017, GASTROENTEROLOGY, V152, P313, DOI 10.1053/j.gastro.2016.10.020
   Kilic Y, 2024, INFLAMM BOWEL DIS, V30, P230, DOI 10.1093/ibd/izad061
   Kobayashi T, 2020, NAT REV DIS PRIMERS, V6, DOI 10.1038/s41572-020-0205-x
   Kuenzig ME, 2020, CAN MED ASSOC J, V192, pE1394, DOI 10.1503/cmaj.190976
   Lewis JD, 2008, INFLAMM BOWEL DIS, V14, P1660, DOI 10.1002/ibd.20520
   Lewis SJ, 1997, SCAND J GASTROENTERO, V32, P920, DOI 10.3109/00365529709011203
   Li C., 2024, Journal of Kunming Medical University, V45, P72
   Lichtenstein GR, 2020, CLIN GASTROENTEROL H, V18, P889, DOI 10.1016/j.cgh.2019.07.022
   Lutgens MWMD, 2013, INFLAMM BOWEL DIS, V19, P789, DOI 10.1097/MIB.0b013e31828029c0
   Lynch WD., 2024, StatPearls
   Maaser C, 2019, J CROHNS COLITIS, V13, P144, DOI 10.1093/ecco-jcc/jjy113
   MacPherson Hugh, 2010, J Evid Based Med, V3, P140, DOI 10.1111/j.1756-5391.2010.01086.x
   Magro F, 2017, J CROHNS COLITIS, V11, P649, DOI 10.1093/ecco-jcc/jjx008
   Marín-Jiménez I, 2016, AM J GASTROENTEROL, V111, P261, DOI 10.1038/ajg.2015.403
   McGing JJ, 2021, ALIMENT PHARM THER, V54, P368, DOI 10.1111/apt.16465
   ODONNELL LJD, 1990, BMJ-BRIT MED J, V300, P439, DOI 10.1136/bmj.300.6722.439
   Olén O, 2020, LANCET, V395, P123, DOI 10.1016/S0140-6736(19)32545-0
   [千圣楠 Qian Shengnan], 2024, [上海针灸杂志, Shanghai Journal of Acupuncture and Moxibustion], V43, P381
   Raine T, 2022, GASTROENTEROLOGY, V162, P1507, DOI 10.1053/j.gastro.2021.09.078
   Rubin DT, 2019, AM J GASTROENTEROL, V114, P384, DOI 10.14309/ajg.0000000000000152
   Sands BE, 2023, J CROHNS COLITIS, V17, P523, DOI 10.1093/ecco-jcc/jjac190.0521
   Sands BE, 2023, J CROHNS COLITIS, V17, P775, DOI 10.1093/ecco-jcc/jjac190.0776
   SCHROEDER KW, 1987, NEW ENGL J MED, V317, P1625, DOI 10.1056/NEJM198712243172603
   Sninsky Jared A, 2022, Am J Gastroenterol, V117, P769, DOI 10.14309/ajg.0000000000001685
   Standardization Administration of the People's Republic of China, 2021, GB/t 12346-2021, Nomenclature and Location of Acupuncture Points
   Sun YJ, 2021, ANN INTERN MED, V174, P1357, DOI 10.7326/M21-1814
   Tinsley A, 2011, ALIMENT PHARM THER, V34, P1328, DOI 10.1111/j.1365-2036.2011.04871.x
   Tsai L, 2022, DIGEST DIS SCI, V67, P2451, DOI 10.1007/s10620-021-07200-1
   Tsai L, 2021, CLIN GASTROENTEROL H, V19, P2031, DOI 10.1016/j.cgh.2020.10.039
   Turner D, 2021, GASTROENTEROLOGY, V160, P1570, DOI 10.1053/j.gastro.2020.12.031
   Ungaro R, 2017, LANCET, V389, P1756, DOI 10.1016/S0140-6736(16)32126-2
   Wang D, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2024.e27524
   Wang X, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-03101-4
   Williet N, 2014, CLIN GASTROENTEROL H, V12, P1246, DOI 10.1016/j.cgh.2014.02.016
   Yang XY, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/319734
   Yarlas A, 2020, J PATIENT-CENTER RES, V7, P189, DOI 10.17294/2330-0698.1722
   Yarlas A, 2018, J CROHNS COLITIS, V12, P600, DOI 10.1093/ecco-jcc/jjy024
   Zhang SS, 2024, PHYTOTHER RES, V38, P970, DOI 10.1002/ptr.8087
   Zhao L, 2017, JAMA INTERN MED, V177, P508, DOI 10.1001/jamainternmed.2016.9378
   Zhu LL, 2024, ANN INTERN MED, V177, P1048, DOI 10.7326/M23-2749
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 70
TC 0
Z9 0
U1 4
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD FEB 27
PY 2025
VL 15
IS 2
AR e094301
DI 10.1136/bmjopen-2024-094301
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Z0T5M
UT WOS:001436138500001
PM 40021194
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Ee, C
   Kay, S
   Reynolds, A
   Lovato, N
   Lacey, J
   Koczwara, B
AF Ee, Carolyn
   Kay, Shelley
   Reynolds, Amy
   Lovato, Nicole
   Lacey, Judith
   Koczwara, Bogda
TI Lifestyle and integrative oncology interventions for cancer-related
   fatigue and sleep disturbances
SO MATURITAS
LA English
DT Review
DE Cancer survivors; Fatigue; Sleep; Exercise; Diet; Integrative oncology
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; RISK-FACTORS; INSOMNIA; SURVIVORS;
   PREVALENCE; MECHANISMS; MEDICINE; YOGA
AB Fatigue, insomnia and sleep disturbances are common after cancer diagnosis, and have a negative impact on quality of life and function. This narrative review synthesised evidence on lifestyle and integrative oncology interventions for cancer-related fatigue, insomnia and sleep disturbances in cancer survivors. There is strong evidence in support of aerobic and strength exercise for the relief of cancer-related fatigue. Yoga, massage therapy, acupuncture, Tai Chi and qigong can also be recommended for cancer-related fatigue. The evidence on yoga, acupuncture and massage therapy for sleep disturbances in cancer is mixed, while exercise appears to have a modest favourable effect. There is insufficient evidence on nutrient supplements or dietary interventions for cancer-related fatigue or insomnia and other sleep disturbances after cancer. Beyond alleviating cancer-related fatigue and insomnia-related symptoms, integrative oncology and lifestyle interventions have potential to effect multiple other benefits, such as improvement in symptoms such as pain and menopausal symptoms. There is a need for well-designed randomised controlled trials of interventions, particularly in the areas of diet and nutrient supplements, and for implementation studies of interventions already supported by evidence.
C1 [Ee, Carolyn; Lacey, Judith] Western Sydney Univ, NICM Hlth Res Inst, Locked Bag 1797, Penrith, NSW 2751, Australia.
   [Ee, Carolyn; Kay, Shelley; Lacey, Judith] Chris OBrien Lifehouse, Support Care & Integrat Oncol Dept, POB M33,Missenden Rd, Camperdown, NSW 2050, Australia.
   [Ee, Carolyn] Flinders Univ S Australia, Caring Futures Inst, GPO Box 2100, Adelaide, SA 5001, Australia.
   [Ee, Carolyn] Western Sydney Univ, Translat Hlth Inst, Locked Bag 1797, Penrith, NSW 2751, Australia.
   [Reynolds, Amy; Lovato, Nicole; Koczwara, Bogda] Flinders Univ S Australia, Flinders Hlth & Med Res Inst Sleep Hlth, GPO Box 2100, Adelaide, SA 5001, Australia.
   [Reynolds, Amy; Lovato, Nicole] Flinders Univ S Australia, Adelaide Inst Sleep Hlth, GPO Box 2100, Adelaide, SA 5001, Australia.
   [Lacey, Judith] Univ Sydney, Sch Med, Sydney, NSW 2006, Australia.
   [Koczwara, Bogda] Flinders Med Ctr, Dept Med Oncol, Flinders Dr, Bedford Pk, SA 5042, Australia.
C3 Western Sydney University; Chris O'Brien Lifehouse; Flinders University;
   Western Sydney University; Flinders University; Adelaide Institute for
   Sleep Health; Flinders University; University of Sydney; Flinders
   Medical Centre
RP Ee, C (corresponding author), Western Sydney Univ, NICM Hlth Res Inst, Locked Bag 1797, Penrith, NSW 2751, Australia.
EM c.ee@westernsydney.edu.au; shelley.kay@lh.org.au;
   amy.reynolds@flinders.edu.au; nicole.lovato@flinders.edu.au;
   judith.lacey@lh.org.au; bogda.koczwara@flinders.edu.au
RI Lovato, Nicole/U-5681-2019; Ee, Carolyn/V-5070-2019; Reynolds,
   Amy/Y-8497-2019; Lacey, Judith/AAI-5754-2021; Koczwara,
   Bogda/AFK-3205-2022
OI Lovato, Nicole/0000-0001-8990-6658; Ee, Carolyn/0000-0002-3363-9199;
   Reynolds, Amy/0000-0001-9534-8699; Lacey, Judith/0000-0002-3751-406X;
   Koczwara, Bogda/0000-0002-1201-1642
FX No funding from an external source was received for the preparation of
   this review.
CR Adams R., J SLEEP RES
   Agbejule OA, 2023, SUPPORT CARE CANCER, V31, DOI 10.1007/s00520-023-08130-6
   Anemoulis M, 2023, NUTRIENTS, V15, DOI 10.3390/nu15030532
   Appleton SL, 2022, NAT SCI SLEEP, V14, P775, DOI 10.2147/NSS.S359437
   Avancini A, 2023, SUPPORT CARE CANCER, V31, DOI 10.1007/s00520-023-08126-2
   Avancini A, 2020, ONCOLOGIST, V25, pE555, DOI 10.1634/theoncologist.2019-0463
   Baguley BJ, 2019, BRIT J NUTR, V122, P527, DOI 10.1017/S000711451800363X
   Bao T., 2023, Am Soc Clin Oncol Educ Book, V43
   Bower JE, 2014, NAT REV CLIN ONCOL, V11, P597, DOI 10.1038/nrclinonc.2014.127
   Brandenbarg D, 2018, SUPPORT CARE CANCER, V26, P393, DOI 10.1007/s00520-017-3920-4
   Campbell KL, 2019, MED SCI SPORT EXER, V51, P2375, DOI 10.1249/MSS.0000000000002116
   Choi S, 2020, J CLIN NEUROPHYSIOL, V37, P39, DOI 10.1097/WNP.0000000000000617
   Chow R, 2023, BMJ SUPPORT PALLIAT, V13, P274, DOI 10.1136/bmjspcare-2021-003244
   Daldoul A, 2023, BMJ SUPPORT PALLIAT, V13, pE51, DOI 10.1136/bmjspcare-2020-002718
   Deleemans JM, 2021, INTEGR CANCER THER, V20, DOI 10.1177/15347354211061733
   Demmelmaier I, 2021, SCAND J MED SCI SPOR, V31, P1144, DOI 10.1111/sms.13930
   Doege D, 2021, CANCERS, V13, DOI 10.3390/cancers13112754
   Dong B, 2023, J ORTHOP SPORT PHYS, V53, P343, DOI 10.2519/jospt.2023.11251
   Dong B, 2019, BREAST CANCER RES TR, V177, P5, DOI 10.1007/s10549-019-05278-w
   Fabi A, 2020, ANN ONCOL, V31, P713, DOI 10.1016/j.annonc.2020.02.016
   Fan RR, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2022-060912
   Fisher MI, 2022, PHYS THER, V102, DOI 10.1093/ptj/pzac120
   Forbes CC, 2020, J CANCER SURVIV, V14, P689, DOI 10.1007/s11764-020-00883-x
   Garland SN, 2019, JNCI-J NATL CANCER I, V111, P1323, DOI 10.1093/jnci/djz050
   Grassi L, 2023, ESMO OPEN, V8, DOI 10.1016/j.esmoop.2023.102047
   Grima NA, 2019, AUST J GEN PRACT, V48, P198
   Han J, 2023, COMPLEMENT THER MED, V75, DOI 10.1016/j.ctim.2023.102954
   Henshall CL, 2019, CANCER NURS, V42, P295, DOI 10.1097/NCC.0000000000000605
   Hilfiker R, 2018, BRIT J SPORT MED, V52, P651, DOI 10.1136/bjsports-2016-096422
   Hirschey R, 2021, CLIN J ONCOL NURS, V25, P697, DOI 10.1188/21.CJON.697-705
   Jacobs S, 2016, PEDIATR BLOOD CANCER, V63, P880, DOI 10.1002/pbc.25902
   Jazieh AR, 2012, J ALTERN COMPLEM MED, V18, P1045, DOI 10.1089/acm.2011.0266
   Kang YE, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-39046-0
   Kleckner A.S., 2022, CHEMOTHERAPY, V14
   Knips L, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009075.pub3
   Kocarnik JM, 2022, JAMA ONCOL, V8, P420, DOI 10.1001/jamaoncol.2021.6987
   Kreutz C, 2019, BREAST CANCER RES TR, V176, P1, DOI 10.1007/s10549-019-05217-9
   Kristoffersen AE, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03606-0
   Lin PJ, 2023, J NATL COMPR CANC NE, V21, P153, DOI 10.6004/jnccn.2022.7080
   Lin PJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419855134
   Lu HB, 2022, HOLIST NURS PRACT, V36, pE27, DOI 10.1097/HNP.0000000000000532
   Luo WT, 2023, CANCER NURS, V46, P120, DOI 10.1097/NCC.0000000000001068
   Luo XC, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.00607
   Mao JJ, 2022, CA-CANCER J CLIN, V72, P144, DOI 10.3322/caac.21706
   Matthews EE, 2022, SEMIN ONCOL NURS, V38, DOI 10.1016/j.soncn.2022.151253
   Mock Victoria, 2007, J Natl Compr Canc Netw, V5, P1054
   Molassiotis A, 2017, ANN ONCOL, V28, P2552, DOI 10.1093/annonc/mdx350
   Moradi-Joo M, 2018, INT J CANCER MANAG, V11, DOI 10.5812/ijcm.10082
   Morrow GR, 2007, ONCOLOGIST, V12, P1, DOI 10.1634/theoncologist.12-S1-1
   Nakano J, 2018, INTEGR CANCER THER, V17, P1048, DOI 10.1177/1534735418807555
   nccn, 2024, NCCN Clinical Practice Guidelines in Oncology: Head and Neck Cancers
   Ni XS, 2019, SUPPORT CARE CANCER, V27, P3701, DOI 10.1007/s00520-019-04911-0
   Pérez-Bilbao T, 2023, NUTRIENTS, V15, DOI 10.3390/nu15041013
   Rock CL, 2022, CA-CANCER J CLIN, V72, P230, DOI 10.3322/caac.21719
   Ryan JL, 2007, ONCOLOGIST, V12, P22, DOI 10.1634/theoncologist.12-S1-22
   Sadeghian M, 2021, NUTR CANCER, V73, P1270, DOI 10.1080/01635581.2020.1795691
   Samuel SR, 2021, J CANCER SURVIV, V15, P799, DOI 10.1007/s11764-020-00972-x
   Sateia MJ, 2017, J CLIN SLEEP MED, V13, P307, DOI 10.5664/jcsm.6470
   Savard J, 2001, SLEEP, V24, P583, DOI 10.1093/sleep/24.5.583
   Schloss J, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.649555
   Schmidt M, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-54
   Shan SN, 2023, SUPPORT CARE CANCER, V31, DOI 10.1007/s00520-023-07926-w
   Song JH, 2021, ONCOL NURS FORUM, V48, P207, DOI 10.1188/21.ONF.207-228
   Sun JR, 2023, FRONT NEUROL, V14, DOI 10.3389/fneur.2023.1139746
   Wan QY, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.856093
   Wang T, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-054597
   Wang YX, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/3996101
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
   World Health Organisation, 2018, WHO GUIDELINES PHARM
   Xiao CH, 2021, SUPPORT CARE CANCER, V29, P3173, DOI 10.1007/s00520-020-05820-3
   Yin JC, 2020, MENT HEALTH PHYS ACT, V19, DOI 10.1016/j.mhpa.2020.100347
   Zhang JL, 2022, PHYTOMEDICINE, V102, DOI 10.1016/j.phymed.2022.154160
   Zhang YB, 2023, SUPPORT CARE CANCER, V31, DOI 10.1007/s00520-023-07619-4
   Zhang YM, 2023, CANCER NURS, V46, P394, DOI 10.1097/NCC.0000000000001124
   Zhang YZ, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.646315
NR 75
TC 13
Z9 15
U1 12
U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD SEP
PY 2024
VL 187
AR 108056
DI 10.1016/j.maturitas.2024.108056
EA JUL 2024
PG 7
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA YF6K5
UT WOS:001267108500001
PM 38981156
OA hybrid
DA 2026-01-16
ER

PT J
AU Ben-Arye, E
   Hirsh, I
   Segev, Y
   Grach, M
   Master, V
   Eden, A
   Samuels, N
   Stein, N
   Gressel, O
   Ostrovsky, L
   Galil, G
   Schmidt, M
   Schiff, E
   Lavie, O
AF Ben-Arye, Eran
   Hirsh, Irena
   Segev, Yakir
   Grach, Michael
   Master, Viraj
   Eden, Arie
   Samuels, Noah
   Stein, Nili
   Gressel, Orit
   Ostrovsky, Ludmila
   Galil, Galit
   Schmidt, Meirav
   Schiff, Elad
   Lavie, Ofer
TI A randomized-controlled trial assessing the effect of intraoperative
   acupuncture on anesthesia-related parameters during gynecological
   oncology surgery
SO JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
LA English
DT Article
DE Integrative oncology; Gynecological oncology; Acupuncture; Pain;
   Intraoperative; Integrative medicine
ID HEART-RATE-VARIABILITY; INTEGRATIVE MEDICINE; NOCICEPTION LEVEL;
   STIMULATION; CANCER; EFFICACY
AB Context and objectivesThe present study examined the impact of intraoperative acupuncture on anesthesia-related parameters in patients undergoing gynecological oncology surgery.MethodsParticipants underwent preoperative integrative oncology (IO) touch/relaxation treatments, followed by intraoperative acupuncture (Group A); preoperative IO treatments without acupuncture (Group B); or standard care only (Group C). Mean arterial pressure (MAP), heart rate (HR), MAP variability (mean of MAP standard deviation), bispectral index (BIS), and calculated blood pressure Average Real Variability (ARV) were measured intraoperatively.ResultsA total of 91 patients participated: Group A, 41; Group B, 24; Group C, 26. Among patients undergoing open laparotomy, Group A showed lower and more stable MAP and HR compared to Group B, (MAP, p = 0.026; HR, p = 0.029) and Group C (MAP, p = 0.025). Mean BIS, from incision to suture closing, was lower in Group A (vs. controls, p = 0.024). In patients undergoing laparoscopic surgery, MAP was elevated within Group A (p = 0.026) throughout surgery, with MAP variability significantly higher in Group A (P = 0.023) and Group B (P = 0.013) 10 min post-incision (vs. pre-incision). All groups showed similar intraoperative and post-anesthesia use of analgesic medication.ConclusionIntraoperative acupuncture was shown to reduce and stabilize MAP and HR, and reduce BIS in gynecology oncology patients undergoing laparotomy, with no impact on perioperative analgesic medication use. In the laparoscopic setting, intraoperative acupuncture was associated with elevated MAP. Further research is needed to explore the hemodynamic and BIS-associated benefits and risks of intraoperative acupuncture, and the impact on the use of analgesic drugs in response to these changes.
C1 [Ben-Arye, Eran; Gressel, Orit; Galil, Galit] Clalit Hlth Serv, Lin Med Ctr, Oncol Serv, Integrat Oncol Program, 35 Rothschild St, Haifa, Israel.
   [Ben-Arye, Eran; Gressel, Orit; Galil, Galit] Clalit Hlth Serv, Zebulun Med Ctr, Oncol Serv, Integrat Oncol Program, 35 Rothschild St, Haifa, Israel.
   [Ben-Arye, Eran; Gressel, Orit; Galil, Galit] Clalit Hlth Serv, Carmel Med Ctr, Oncol Serv, Integrat Oncol Program, 35 Rothschild St, Haifa, Israel.
   [Ben-Arye, Eran; Segev, Yakir; Gressel, Orit; Schiff, Elad; Lavie, Ofer] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
   [Hirsh, Irena; Grach, Michael; Eden, Arie; Schmidt, Meirav] Carmel Hosp, Dept Anesthesiol Crit Care & Pain Med, Haifa, Israel.
   [Segev, Yakir; Ostrovsky, Ludmila; Lavie, Ofer] Carmel Hosp, Dept Obstet & Gynecol, Haifa, Israel.
   [Master, Viraj] Emory Univ, Dept Urol, Atlanta, GA 30322 USA.
   [Master, Viraj] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA.
   [Samuels, Noah] Hebrew Univ Jerusalem, Shaarei Zedek Med Ctr, Fac Med, Ctr Integrat Complementary Med, Jerusalem, Israel.
   [Stein, Nili] Carmel Hosp, Dept Community Med & Epidemiol, Haifa, Israel.
   [Schiff, Elad] Bnai Zion Hosp, Dept Internal Med, Haifa, Israel.
   [Schiff, Elad] Bnai Zion Hosp, Integrat Med Serv, Haifa, Israel.
C3 Clalit Health Services; Clalit Health Services; Clalit Health Services;
   Carmel Medical Center; Technion Israel Institute of Technology;
   Rappaport Faculty of Medicine; Clalit Health Services; Carmel Medical
   Center; Clalit Health Services; Carmel Medical Center; Emory University;
   Emory University; Hebrew University of Jerusalem; Shaare Zedek Medical
   Center; Clalit Health Services; Carmel Medical Center; Bnai Zion Medical
   Center; Bnai Zion Medical Center
RP Ben-Arye, E (corresponding author), Clalit Hlth Serv, Lin Med Ctr, Oncol Serv, Integrat Oncol Program, 35 Rothschild St, Haifa, Israel.; Ben-Arye, E (corresponding author), Clalit Hlth Serv, Zebulun Med Ctr, Oncol Serv, Integrat Oncol Program, 35 Rothschild St, Haifa, Israel.; Ben-Arye, E (corresponding author), Clalit Hlth Serv, Carmel Med Ctr, Oncol Serv, Integrat Oncol Program, 35 Rothschild St, Haifa, Israel.; Ben-Arye, E (corresponding author), Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
EM eranben@netvision.net.il
CR Acar HV, 2013, J ALTERN COMPLEM MED, V19, P420, DOI 10.1089/acm.2012.0494
   Baldawi M, 2022, J INTEGR COMPLEMENT, V28, P683, DOI 10.1089/jicm.2021.0429
   Ben-Arye E, 2023, CANCER-AM CANCER SOC, V129, P908, DOI 10.1002/cncr.34542
   Ben-Arye E, 2022, SUPPORT CARE CANCER, V30, P4345, DOI 10.1007/s00520-022-06865-2
   Ben-Arye E, 2021, J CANCER RES CLIN, V147, P2361, DOI 10.1007/s00432-020-03506-1
   Ben-Arye E, 2016, SUPPORT CARE CANCER, V24, P1457, DOI 10.1007/s00520-016-3093-6
   Ben-Arye E, 2013, MED ONCOL, V30, DOI 10.1007/s12032-013-0511-1
   Ben-Arye E, 2012, PATIENT EDUC COUNS, V89, P423, DOI 10.1016/j.pec.2012.02.011
   Ben-Israel N, 2013, J CLIN MONIT COMPUT, V27, P659, DOI 10.1007/s10877-013-9487-9
   Chen JH, 2020, THORAC CANCER, V11, P928, DOI 10.1111/1759-7714.13343
   Cheng Xiang, 2010, Zhongguo Zhen Jiu, V30, P305
   Chung JWY, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/819871
   Coulombe MA, 2021, EUR J ANAESTH, V38, P512, DOI 10.1097/EJA.0000000000001431
   Edry R, 2016, ANESTHESIOLOGY, V125, P193, DOI 10.1097/ALN.0000000000001130
   Faiz Seyed Hamid Reza, 2019, Anesth Pain Med, V9, pe96172, DOI [10.5812/aapm.96172, 10.5812/aapm.96172]
   Hamvas Sz, 2023, Complement Ther Med, V72, P102905, DOI [10.1016/j.ctim.2022.102905, 10.1016/j.ctim.2022.102905]
   Liu X, 2015, ACUPUNCT MED, V33, P270, DOI 10.1136/acupmed-2014-010749
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mascha EJ, 2015, ANESTHESIOLOGY, V123, P79, DOI 10.1097/ALN.0000000000000686
   Paraskeva A, 2004, AM J CHINESE MED, V32, P789, DOI 10.1142/S0192415X04002363
   Petersen RW, 2002, BJOG-INT J OBSTET GY, V109, P386, DOI 10.1016/S1470-0328(02)01271-5
   Rahimi M, 2019, MED ACUPUNCT, V31, P123, DOI 10.1089/acu.2018.1330
   Rithirangsriroj K, 2015, GYNECOL ONCOL, V136, P82, DOI 10.1016/j.ygyno.2014.10.025
   Sato N, 2000, SURG ENDOSC, V14, P362, DOI 10.1007/s004640000155
   Segev Y, 2021, SUPPORT CARE CANCER, V29, P4055, DOI 10.1007/s00520-020-05961-5
   Shahiri TS, 2022, J CLIN MONIT COMPUT, V36, P623, DOI 10.1007/s10877-021-00772-3
   Shalom-Sharabi I, 2017, J CANCER RES CLIN, V143, P2535, DOI 10.1007/s00432-017-2509-0
   Sharp DM, 2010, EUR J CANCER, V46, P312, DOI 10.1016/j.ejca.2009.10.006
   Stener-Victorin E, 2005, REPROD BIOL ENDOCRIN, V3, DOI 10.1186/1477-7827-3-44
   Stomberg M W, 2001, AANA J, V69, P218
   Vagedes J, 2023, PSYCHOSOM MED, V85, P53, DOI 10.1097/PSY.0000000000001153
   Wang H, 2014, BRIT J ANAESTH, V112, P1075, DOI 10.1093/bja/aeu001
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
   Yu JB, 2014, MED SCI MONITOR, V20, P406, DOI 10.12659/MSM.890111
   Zanatta P, 2011, CLIN NEUROPHYSIOL, V122, P2093, DOI 10.1016/j.clinph.2011.03.017
NR 35
TC 6
Z9 7
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0171-5216
EI 1432-1335
J9 J CANCER RES CLIN
JI J. Cancer Res. Clin. Oncol.
PD SEP
PY 2023
VL 149
IS 11
BP 8177
EP 8189
DI 10.1007/s00432-023-04758-3
EA APR 2023
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA M9VT4
UT WOS:000983706700003
PM 37061627
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Guzmán, RMMAY
   Chaparro, JGT
   Gómez, AD
   Eslava, VMS
   Ruiz, GCT
   Garduño, IMT
   Madrid, ID
   Figueroa, IG
   Betancourt, AM
   Arrieta, O
AF Menendez-Aponte y Guzman, Raquel Maria
   Turcott Chaparro, Jenny Georgina
   De la Piedra Gomez, Amanda
   Sandoval Eslava, Victoria Margarita
   Tarditi Ruiz, Gina Carolina
   Tapia Garduno, Ilse Merari
   Madrid, Irma De la Torre
   Figueroa, Irma Gallegos
   Betancourt, Alejandro Mohar
   Arrieta, Oscar
TI Effect of complementary Integrative Oncology on anxiety, depression and
   quality of life in thoracic cancer patients: A pilot study
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Article
DE Integrative oncology; Acupuncture; Mindfulness; Cognitive behavior
   therapy; Thoracic cancer; Lung cancer
ID CELL LUNG-CANCER; EORTC QLQ-LC13; ASSOCIATION; PROGNOSIS; MEDICINE;
   ACUPUNCTURE
AB Purpose: Thoracic-cancer (TC) patients have an extensive toll taken in terms of health-related quality of life (HRQL). Integrative Oncology (IO) is recognized as a valid complement to any Standard-Therapy treatment to improve outcomes in TC patients. The objective of this pilot-study was to evaluate the effect of adding IO (acupuncture, Cognitive-Behavior Therapy and mindfulness) in terms of depression, anxiety and HRQL.
   Methods: TC patients who attended the Thoracic Oncology-Unit from July to September 2018 were invited to participate. A total of 16 patients were included in the study, 8 patients were required to attend 5 weekly sessions of IO and 8 patients were invited as controls. Anxiety, depression and HRQL were measured at baseline and after completing 5 sessions of IO or 5 weeks, using the HADS scale and the QLQ-C30 scale.
   Results: A total of 8 patients in the IO group attended the 5 sessions and 8 patients were followed as controls. Compliance with the therapies was high, none of the patients dropped out from the study. A tendency for improvement in anxiety, fatigue, pain and dyspnea was observed in patients attending IO, though not statistically significant likely due to sample size.
   Conclusions: IO therapies are well accepted among TC patients. Larger studies are necessary with robust sample sizes to improve conclusions regarding outcome improvements.
C1 [Menendez-Aponte y Guzman, Raquel Maria; De la Piedra Gomez, Amanda; Sandoval Eslava, Victoria Margarita; Tarditi Ruiz, Gina Carolina; Tapia Garduno, Ilse Merari; Madrid, Irma De la Torre; Figueroa, Irma Gallegos; Betancourt, Alejandro Mohar] Natl Canc Inst INCan, Integrat Oncol Ctr CAAI, Num 22,Sect 16, Tlalpan 14080, Ciudad De Mexic, Mexico.
   [Turcott Chaparro, Jenny Georgina; Betancourt, Alejandro Mohar; Arrieta, Oscar] Natl Canc Inst INCan, Thorac Oncol Unit, Num 22,Sect 16, Tlalpan 14080, Ciudad De Mexic, Mexico.
   [Turcott Chaparro, Jenny Georgina; Betancourt, Alejandro Mohar; Arrieta, Oscar] Natl Canc Inst INCan, Lab Personalized Med, Num 22,Sect 16, Tlalpan 14080, Ciudad De Mexic, Mexico.
C3 Instituto Nacional de Cancerologia (INCAN); Instituto Nacional de
   Cancerologia (INCAN); Instituto Nacional de Cancerologia (INCAN)
RP Arrieta, O (corresponding author), Natl Canc Inst INCan, Thorac Oncol Unit, Num 22,Sect 16, Tlalpan 14080, Ciudad De Mexic, Mexico.; Arrieta, O (corresponding author), Natl Canc Inst INCan, Lab Personalized Med, Num 22,Sect 16, Tlalpan 14080, Ciudad De Mexic, Mexico.
EM ccraquel@hotmail.com; jennyturcott@gmail.com; amandadpg@hotmail.com;
   dravsandovale@gmail.com; gtarditi@prodigy.net.mx; mera2306@gmail.com;
   idelatorre44@gmail.com; igallegosf@yahoo.com.mx;
   alejandromohar@gmail.com; ogar@unam.mx
OI De la Piea Gómez, Amanda/0000-0003-1338-4181; Tarditi,
   Gina/0009-0006-0847-1503
FU AstraZeneca [NCR-18-13933]
FX The development of this study was made possible thanks to the support of
   AstraZeneca (NCR-18-13933).
CR Armstrong K, 2018, SUPPORT CARE CANCER, V26, P2267, DOI 10.1007/s00520-017-4007-y
   Arrieta O, 2018, QUAL LIFE RES, V27, P2709, DOI 10.1007/s11136-018-1930-4
   Arrieta O, 2013, ANN SURG ONCOL, V20, P1941, DOI 10.1245/s10434-012-2793-5
   Arrieta O, 2012, J THORAC ONCOL, V7, P1228, DOI 10.1097/JTO.0b013e3182582a93
   Arrieta O, 2012, LUNG CANCER, V77, P205, DOI 10.1016/j.lungcan.2012.02.005
   BERGMAN B, 1994, EUR J CANCER, V30A, P635, DOI 10.1016/0959-8049(94)90535-5
   Cheng CS, 2017, SUPPORT CARE CANCER, V25, P3807, DOI 10.1007/s00520-017-3812-7
   Daniels Sheena, 2015, J Adv Pract Oncol, V6, P54, DOI 10.6004/jadpro.2015.6.1.5
   Deng GE, 2013, CHEST, V143, pE420, DOI 10.1378/chest.12-2364
   Ferlay J, 2019, INT J CANCER, V144, P1941, DOI 10.1002/ijc.31937
   Frenkel M, 2018, J ALTERN COMPLEM MED, V24, P862, DOI 10.1089/acm.2018.0175
   Galindo Vázquez Oscar, 2015, Salud Ment, V38, P253
   Turcott JG, 2019, NUTR CANCER, V71, P409, DOI 10.1080/01635581.2018.1506488
   Hofmann SG, 2017, PSYCHIAT CLIN N AM, V40, P739, DOI 10.1016/j.psc.2017.08.008
   Hulbert-Williams NJ, 2018, CURR OPIN SUPPORT PA, V12, P276, DOI 10.1097/SPC.0000000000000360
   Mao Jun J, 2007, Acupunct Med, V25, P158
   Minchom A, 2016, EUR J CANCER, V61, P102, DOI 10.1016/j.ejca.2016.03.078
   Nipp RD, 2017, J CLIN ONCOL, V35, P2551, DOI 10.1200/JCO.2016.71.3404
   Sánchez-Lara K, 2012, NUTR CANCER, V64, P526, DOI 10.1080/01635581.2012.668744
   Schellekens MPJ, 2014, BMC CANCER, V14, DOI 10.1186/1471-2407-14-3
   Turcott JG, 2018, SUPPORT CARE CANCER, V26, P3029, DOI 10.1007/s00520-018-4154-9
NR 21
TC 5
Z9 8
U1 1
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD AUG
PY 2019
VL 36
BP 56
EP 63
DI 10.1016/j.ctcp.2019.05.003
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA IN6CJ
UT WOS:000478763500010
PM 31383444
DA 2026-01-16
ER

PT J
AU Kannan, P
   Lam, HY
   Ma, TK
   Lo, CN
   Mui, TY
   Tang, WY
AF Kannan, Priya
   Lam, Hiu Ying
   Ma, Tsz Kiu
   Lo, Chiu Ngai
   Mui, Ting Yan
   Tang, Wing Yan
TI Efficacy of physical therapy interventions on quality of life and upper
   quadrant pain severity in women with post-mastectomy pain syndrome: a
   systematic review and meta-analysis
SO QUALITY OF LIFE RESEARCH
LA English
DT Review
DE Acupuncture; Decongestive therapy; Exercise; Post-mastectomy pain
   syndrome; Quality of Life
ID BREAST-CANCER SURVIVORS; EXERCISE THERAPY; SHOULDER PAIN; SINGLE-BLIND;
   IMPACT; PREVALENCE; PROGRAM; SURGERY; TRIAL
AB Purpose To determine the efficacy of physical therapy interventions on quality of life (QoL) and pain severity in post-mastectomy pain syndrome (PMPS). Methods Multiple databases were searched from database inception to October 2020. Searches were limited to human studies published in either English or Chinese in peer-reviewed journals with full text available for randomized controlled trials conducted on females. Trials comparing the effectiveness of physical therapy interventions against control conditions on QoL and pain were included. Results Eighteen trials were included in the review. The pooled analysis of the four exercise trials revealed a significant effect of the intervention on general [standardized mean difference [SMD]: 0.87 (95%CI: 0.36, 1.37); p = 0.001], physical [SMD: 0.34 (95%CI: 0.01, 0.66); p = 0.044], and mental health components [SMD: 0.27 (95%CI: 0.03, 0.51); p = 0.027] of QoL compared with the control condition. Meta-analyses of six exercise trials, two myofascial release trials, and two acupuncture trials revealed a significant improvement in pain severity in the treatment group than in the control group. However, meta-analyses of two studies revealed a non-significant effect of compression therapy compared to control on pain severity. Conclusion Our meta-analyses found that exercise is beneficial for improving the QoL and pain severity of women with PMPS. Future studies are needed to determine the optimal parameters for exercise interventions designed to improve QoL and pain severity in women with PMPS. The effect of acupuncture, myofascial release, and compression therapy remains inconclusive, and future research is required to validate the effect of these interventions on PMPS.
C1 [Kannan, Priya; Lam, Hiu Ying; Ma, Tsz Kiu; Lo, Chiu Ngai; Mui, Ting Yan; Tang, Wing Yan] Hong Kong Polytech Univ, Dept Rehabil Sci, Hung Hom, Kowloon, Hong Kong, Peoples R China.
C3 Hong Kong Polytechnic University
RP Kannan, P (corresponding author), Hong Kong Polytech Univ, Dept Rehabil Sci, Hung Hom, Kowloon, Hong Kong, Peoples R China.
EM priya.kannan@polyu.edu.hk
CR Ammitzboll G, 2020, BREAST CANCER RES TR, V179, P173, DOI 10.1007/s10549-019-05461-z
   [Anonymous], 2020, J PHYSIOTHER, V66, P59, DOI 10.1016/j.jphys.2019.08.005
   Ashing-Giwa KT, 2009, ONCOL NURS FORUM, V36, P79, DOI 10.1188/09.ONF.79-88
   Balshem H, 2011, J CLIN EPIDEMIOL, V64, P401, DOI 10.1016/j.jclinepi.2010.07.015
   Beyaz SG, 2016, CHINESE MED J-PEKING, V129, P66, DOI 10.4103/0366-6999.172589
   Bland M., 2015, INT J STAT MED RES, V4, P57, DOI [DOI 10.6000/1929-6029.2015.04.01.6, 10.6000/1929-6029.2015.04.01.6]
   Caffo O, 2003, BREAST CANCER RES TR, V80, P39, DOI 10.1023/A:1024435101619
   Cantarero-Villanueva I, 2012, PAIN MED, V13, P1509, DOI 10.1111/j.1526-4637.2012.01481.x
   Castro-Martín E, 2017, ARCH PHYS MED REHAB, V98, P832, DOI 10.1016/j.apmr.2016.11.019
   Cheema B, 2008, BREAST CANCER RES TR, V109, P9, DOI 10.1007/s10549-007-9638-0
   Conejo I, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2236-3
   Couceiro Tania Cursino de Menezes, 2009, Rev. Bras. Anestesiol., V59, P358
   De Groef A, 2015, ARCH PHYS MED REHAB, V96, P1140, DOI 10.1016/j.apmr.2015.01.006
   Couceiro TCD, 2014, PAIN MANAG NURS, V15, P731, DOI 10.1016/j.pmn.2013.07.011
   Dong XS, 2019, HEALTH QUAL LIFE OUT, V17, DOI 10.1186/s12955-019-1183-0
   Farrar JT, 2001, PAIN, V94, P149, DOI 10.1016/S0304-3959(01)00349-9
   García-Ceberino JM, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17010344
   GONG Y, 2020, MEDICINE
   Guyatt GH, 2011, J CLIN EPIDEMIOL, V64, P1311, DOI [10.1016/j.jclinepi.2011.06.004, 10.1016/j.jclinepi.2011.03.017]
   Guyatt GH, 2011, J CLIN EPIDEMIOL, V64, P1294, DOI 10.1016/j.jclinepi.2011.03.017
   Guyatt GH, 2011, J CLIN EPIDEMIOL, V64, P1303, DOI 10.1016/j.jclinepi.2011.04.014
   Hammond EA, 2020, NEUROREHAB NEURAL RE, V34, P235, DOI 10.1177/1545968319899918
   Hansdorfer-Korzon R, 2016, PATIENT PREFER ADHER, V10, DOI 10.2147/PPA.S108326
   Hoskins CN, 1996, PSYCHO-ONCOLOGY, V5, P31, DOI 10.1002/(SICI)1099-1611(199603)5:1<31::AID-PON210>3.0.CO;2-2
   Hwang JH, 2008, YONSEI MED J, V49, P443, DOI 10.3349/ymj.2008.49.3.443
   Irwin ML, 2008, CANCER-AM CANCER SOC, V112, P2593, DOI 10.1002/cncr.23446
   Johansson K, 2020, LYMPHAT RES BIOL, V18, P129, DOI 10.1089/lrb.2018.0064
   Kuehn T, 2000, BREAST CANCER RES TR, V64, P275, DOI 10.1023/A:1026564723698
   Lee SA, 2010, CLIN REHABIL, V24, P600, DOI 10.1177/0269215510362324
   Liberati A, 2009, ANN INTERN MED, V151, pW65, DOI [10.7326/0003-4819-151-4-200908180-00136, 10.1371/journal.pmed.1000100, 10.1136/bmj.b2700]
   Ligabue MB, 2019, BREAST CANCER RES TR, V175, P191, DOI 10.1007/s10549-019-05136-9
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Melam GR, 2016, BMC WOMENS HEALTH, V16, DOI 10.1186/s12905-016-0303-9
   Mullen EJ, 2006, RES SOCIAL WORK PRAC, V16, P84, DOI 10.1177/1049731505280950
   Nyrop KA, 2017, ONCOLOGIST, V22, P1238, DOI 10.1634/theoncologist.2017-0174
   Paulo TRS, 2019, HEALTH QUAL LIFE OUT, V17, DOI 10.1186/s12955-019-1090-4
   Paxton RJ, 2012, CANCER-AM CANCER SOC, V118, P4024, DOI 10.1002/cncr.27389
   Pilat A., 2012, Fascia: The Tensional Network of the Human Body, P311
   Quinlan-Woodward J, 2016, ONCOL NURS FORUM, V43, P725, DOI 10.1188/16.ONF.725-732
   Serra-Añó P, 2019, SUPPORT CARE CANCER, V27, P2633, DOI 10.1007/s00520-018-4544-z
   Silver J, 2007, J SURG ONCOL, V95, P427, DOI 10.1002/jso.20780
   Singh B, 2018, ARCH PHYS MED REHAB, V99, P2621, DOI 10.1016/j.apmr.2018.03.026
   Tatham B, 2013, PHYSIOTHER CAN, V65, P321, DOI 10.3138/ptc.2012-06
   Lacomba MT, 2010, CLIN J PAIN, V26, P320, DOI 10.1097/AJP.0b013e3181c4904a
   Vacek PM, 2003, QUAL LIFE RES, V12, P527, DOI 10.1023/A:1025098108717
   VINOKUR AD, 1990, CANCER-AM CANCER SOC, V65, P1242, DOI 10.1002/1097-0142(19900301)65:5<1242::AID-CNCR2820650535>3.0.CO;2-1
   Waltho D., 2016, J SURG, V59, p342 350, DOI [10.1503/cjs.000716, DOI 10.1503/CJS.000716]
   Wan X, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-135
   Wenzel LB, 1999, CANCER, V86, P1768, DOI 10.1002/(SICI)1097-0142(19991101)86:9<1768::AID-CNCR19>3.0.CO;2-O
   Zeng YC, 2014, BREAST CANCER-TOKYO, V21, P262, DOI 10.1007/s12282-014-0521-7
NR 50
TC 18
Z9 25
U1 2
U2 14
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD APR
PY 2022
VL 31
IS 4
BP 951
EP 973
DI 10.1007/s11136-021-02926-x
EA JUN 2021
PG 23
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 0A4WL
UT WOS:000668047300001
PM 34185226
OA Green Submitted, Green Accepted, hybrid
DA 2026-01-16
ER

PT J
AU Hempen, M
   Hummelsberger, J
AF Hempen, Moritz
   Hummelsberger, Josef
TI The state of evidence in acupuncture: A review of metaanalyses and
   systematic reviews of acupuncture evidence (update 2017-2022)
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Acupuncture; Acupuncture effectiveness; Acupuncture review; Acupuncture
   evidence
AB Introduction: Over the last decades, acupuncture research has increased drastically. As a result, it has become more and more difficult to oversee the amount of evidence concerning its effect in various medical conditions. Different comparative reviews aimed to roughly assess individual strength of acupuncture evidence, covering the years 2005-2017. Our review intends to assess the level of acupuncture evidence for any medical condition available, concerning the years 2017-2022. Methods: We searched the pubmed database for 'acupuncture' and filtered the results towards systematic reviews and metanalyses (SR/MA). Results were allocated towards medical disciplines and sorted to medical conditions. Each SR/MA was rated concerning quality of review (QoR), quality of data (QoD), and quality of evidence (QoE). To facilitate a rough overview, results were assessed into either of four categories: i) evidence of positive effect, ii) evidence of potential positive effect, iii) insufficient/unclear evidence, iv) no evidence of effect/evidence of no effect. Results: After considering exclusion criteria, 862 SR/MA remained for evaluation. Results were allocated and sorted as described, resulting in 184 medical conditions. Of these, in ten medical conditions SR/MA supported evidence of positive effect: chronic pain, low-back pain, knee osteoarthritis, postoperative nausea and vomiting (PONY), migraine, tension-type headache, cancer-related fatigue, menopausal symptoms, female infertility (additional to medical reproductive treatment), chronic prostatitis/chronic pelvic pain syndrome in men. In another 82 medical conditions SR/MA supported evidence of potential positive effect, in another 86 medical conditions SR/MA revealed unclear/insufficient evidence, and in another six medical conditions no evidence of effect/evidence of no effect was found. Compared with previous reviews until the year 2017, the number of medical conditions with higher quality evidence levels has increased, namely evidence of positive effect and evidence of potential positive effect. Discussion and conclusion: Compared to previous years, the amount and quality of acupuncture evidence has increased in the years 2017-2022. In total, 862 included SR/MA resulted in a comparative review of 184 medical conditions. Evidence of positive effect was revealed ten medical conditions, another 82 showed evidence of potential positive effect. 86 medical indications showed insufficient evidence for a firm conclusion, six conditions showed no evidence of effect/evidence of no effect. Although general quality of evidence has dramatically increased compared to the previous years, lack of underlying high-quality trials in some cases seems to compromise a consistent comparability between SR/MA. This issue should be addressed for future studies and guidelines such as STRICTA and CONSORT should strictly be obtained.
C1 [Hempen, Moritz; Hummelsberger, Josef] SMS Int Soc Chinese Med, Franz Joseph Str 38, D-80801 Munich, Germany.
RP Hempen, M (corresponding author), SMS Int Soc Chinese Med, Franz Joseph Str 38, D-80801 Munich, Germany.
EM m.hempen@tcm.edu
OI Hempen, Moritz/0009-0005-0602-485X
FU SMS - International Society for Chinese Medicine
FX The project was funded by the SMS - International Society for Chi-nese
   Medicine.
CR [Anonymous], 2024, Deutsche Gesellschaft fur Orthopadie und Unfallchirurgie e.V. Gonarthrose (Living Guideline)
   Australian Government Department of Veterans' Affairs, 2010, Alternative Therapies and Department of Veterans' Affairs Gold and White Card Arrangements
   Brinkhaus B, 2013, ANN INTERN MED, V158, P225, DOI 10.7326/0003-4819-158-4-201302190-00002
   Candon M, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2021.42509
   Chang SC, 2017, NEUROUROL URODYNAM, V36, P474, DOI 10.1002/nau.22958
   DGfGuGeV (DGGG), 2021, Periund Postmenopause-Diagnostik und Interventionen
   DGfNeV (DGN), 2023, S1-Leitlinie Diagnostik und Therapie des Kopfschmerzes vom Spannungstyp
   DGfPFuGeV (DGPFG), 2019, Psychosomatisch orientierte Diagnostik und Therapie bei Fertilitatsstorungen
   Fan SQ, 2021, J NEUROL, V268, P4128, DOI 10.1007/s00415-020-10178-x
   Fei YT, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj-2021-064345
   Franco JVA, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012551.pub2
   Fu CW, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000020301
   Gao Z, 2021, J PAIN RES, V14, DOI 10.2147/JPR.S300911
   Hempel S., 2014, VA evidence-based synthesis program reports. Evidence map of acupuncture
   Jang A, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420949679
   Ji ZC, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-03099-9
   John Bland, 1979, Acupuncture, P2
   Kaptchuk TJ, 2020, MED ACUPUNCT, V32, P352, DOI 10.1089/acu.2020.1483
   Kolokotsios S, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.14237
   Lee B, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2024.e25650
   Lee B, 2023, CANCERS, V15, DOI 10.3390/cancers15245875
   Li T, 2021, MENOPAUSE, V28, P564, DOI 10.1097/GME.0000000000001767
   Ma B, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147244
   MacPherson H, 2017, PAIN, V158, P784, DOI 10.1097/j.pain.0000000000000747
   McDonald J., 2017, The Acupuncture Evidence Project: A Comparative Literature Review (Revised Edition)
   Mu JL, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013814
   Naguit N, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.20888
   Qin ZS, 2022, EUR UROL OPEN SCI, V46, P55, DOI 10.1016/j.euros.2022.10.005
   Quan Kewei, 2022, Evid Based Complement Alternat Med, V2022, P3595033, DOI [10.1155/2022/3595033, 10.1155/2022/3595033]
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Streitberger K, 1998, LANCET, V352, P364, DOI 10.1016/S0140-6736(97)10471-8
   Svenkerud S, 2018, ACUPUNCT MED, V36, P349, DOI 10.1136/acupmed-2017-011519
   Tian H, 2022, BIOMED RES INT, V2022, DOI 10.1155/2022/6561633
   Trinczek K, 2015, FORSCH KOMPLEMENTMED, V22, P118, DOI 10.1159/000381151
   Turkistani A, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.17601
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Witt CM, 2009, FORSCH KOMPLEMENTMED, V16, P91, DOI 10.1159/000209315
   Xiao X, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/5865697
   Yuan T, 2019, PAIN RES MANAG, V2019, DOI 10.1155/2019/2653792
   Zhang GS, 2018, ACUPUNCT MED, V36, P204, DOI 10.1136/acupmed-2017-011484
   Zhang Y, 2018, SUPPORT CARE CANCER, V26, P415, DOI 10.1007/s00520-017-3955-6
   Zhao FY, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.666988
   Zhao L, 2019, JAMA INTERN MED, V179, P1388, DOI 10.1001/jamainternmed.2019.2407
   Zheng XY, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.858587
   Zhu KX, 2024, FRONT PHARMACOL, V15, DOI 10.3389/fphar.2024.1293468
NR 46
TC 3
Z9 5
U1 6
U2 12
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD MAY
PY 2025
VL 89
AR 103149
DI 10.1016/j.ctim.2025.103149
EA MAR 2025
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA Z7O8H
UT WOS:001440761300001
PM 40021024
OA gold
DA 2026-01-16
ER

PT J
AU Zhou, M
   Pang, F
   Liao, DM
   He, XL
   Yang, YH
   Tang, CL
AF Zhou, Min
   Pang, Fang
   Liao, Dongmei
   He, Xinlu
   Yang, Yunhao
   Tang, Chenglin
TI Electroacupuncture at Fengchi(GB20) and Yanglingquan(GB34) Ameliorates
   Paralgesia through Microglia-Mediated Neuroinflammation in a Rat Model
   of Migraine
SO BRAIN SCIENCES
LA English
DT Article
DE migraine; electroacupuncture; paralgesia; microglia; inflammatory
   response
ID CENTRAL SENSITIZATION; TRIGEMINOVASCULAR PATHWAY; INFLAMMATORY FACTORS;
   SIGNALING PATHWAY; PAIN; HYPERSENSITIVITY; STIMULATION; CONTRIBUTES;
   MODULATION; ALLODYNIA
AB Background: Multiple studies have suggested that paralgesia (hyperalgesia and cutaneous allodynia) in migraine reflects the activation and sensitisation of the trigeminovascular system (TGVS). In particular, it reflects the second-order and higher nerve centre sensitisation, which is caused and maintained by neuroinflammation. Microglia activation leads to the release of proinflammatory cytokines involved in inflammatory responses. Accumulating evidence indicates that electroacupuncture (EA) is effective in ameliorating paralgesia, but the underlying mechanisms of EA in migraine attacks caused by microglia and microglia-mediated inflammatory responses are still unclear. The purpose of this study was to explore whether EA could ameliorate the dysregulation of pain sensation by suppressing microglial activation and the resulting neuroinflammatory response, and to evaluate whether this response was regulated by Toll-like receptor 4 (TLR4)/nuclear factor-kappa B(NF-kappa B) in the trigeminal nucleus caudalis (TNC) in a rat model of migraine. Methods: Repeated Inflammatory Soup (IS) was infused into the dura for seven sessions to establish a recurrent migraine-like rat model, and EA treatment was administered at Fengchi (GB20) and Yanglingquan (GB34) after daily IS infusion. Facial mechanical withdrawal thresholds were measured to evaluate the change in pain perception, and plasma samples and the TNC tissues of rats were collected to examine the changes in calcitonin gene-related peptide (CGRP), the Ibal-1-labelled microglial activation, and the resulting inflammatory response, including interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and their regulatory molecules TLR4/NF-kappa B, via enzyme-linked immunosorbent assay (ELISA), real-time polymerase chain reaction (RT-PCR), immunohistochemistry (IHC) and Western blot analysis. Results: Repeated IS injections into the dura induced facial mechanical paralgesia, which is the manifestation of migraine attacks, and increased the expression of CGRP, Ibal-1, microglial mediated inflammatory cytokines (IL-1 beta, TNF-alpha, IL-6), and regulatory molecules TLR4/NF-kappa B. EA at GB20/34 significantly attenuated repetitive IS-induced pain hypersensitivity. This effect was consistent with decreased levels of CGRP and inflammatory cytokines in the plasma and the TNC via the inhibition of microglia activation, and this response may be regulated by TLR4/NF-kappa B. Conclusions: EA ameliorated paralgesia in repetitive IS-induced migraine-like rats, which was mainly mediated by a reduction in microglial activation and microglial-mediated inflammatory responses that could be regulated by TLR4/NF-kappa B.
C1 [Zhou, Min; Pang, Fang; Liao, Dongmei; He, Xinlu; Yang, Yunhao; Tang, Chenglin] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China.
   [Zhou, Min; Pang, Fang; Liao, Dongmei; He, Xinlu; Yang, Yunhao; Tang, Chenglin] Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 400016, Peoples R China.
C3 Chongqing Medical University
RP Tang, CL (corresponding author), Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China.; Tang, CL (corresponding author), Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 400016, Peoples R China.
EM tangchenglin@cqmu.edu.cn
FU Key Discipline Construction Project of Acupuncture Moxibustion and
   Massage of Chongqing Health Commission [472020320220021]; College of
   Traditional Chinese Medicine of Chongqing Medical University
   [2021-ZDXK-D04]; Joint Project of Chongqing Health and Family Planning
   Commission and Science and Technology Commission [ZY201801007];
   Chongqing Yuzhong District Science and Technology Plan Project
   [20200116]
FX This study was supported by the Key Discipline Construction Project of
   Acupuncture Moxibustion and Massage of Chongqing Health Commission
   (472020320220021), College of Traditional Chinese Medicine of Chongqing
   Medical University (No: 2021-ZDXK-D04), Joint Project of Chongqing
   Health and Family Planning Commission and Science and Technology
   Commission (No: ZY201801007), and Chongqing Yuzhong District Science and
   Technology Plan Project (No: 20200116).
CR Agalave NM, 2014, PAIN, V155, P1802, DOI 10.1016/j.pain.2014.06.007
   Al-Hassany L, 2022, LANCET NEUROL, V21, P284, DOI 10.1016/S1474-4422(21)00409-9
   Bernstein C, 2012, J CLIN NEUROL, V8, P89
   Bishop J, 2019, PAIN, V160, P2161, DOI 10.1097/j.pain.0000000000001583
   Boyer N, 2017, PAIN, V158, P2025, DOI 10.1097/j.pain.0000000000001007
   Boyer N, 2014, PAIN, V155, P1196, DOI 10.1016/j.pain.2014.03.001
   Bryant CE, 2010, NAT REV MICROBIOL, V8, P8, DOI 10.1038/nrmicro2266
   Burstein R, 1998, J NEUROPHYSIOL, V79, P964, DOI 10.1152/jn.1998.79.2.964
   Buse DC, 2019, HEADACHE, V59, P306, DOI 10.1111/head.13459
   CHAPLAN SR, 1994, J NEUROSCI METH, V53, P55, DOI 10.1016/0165-0270(94)90144-9
   Charles A, 2019, LANCET, V394, P1765, DOI 10.1016/S0140-6736(19)32504-8
   Charles A, 2018, LANCET NEUROL, V17, P174, DOI 10.1016/S1474-4422(17)30435-0
   Chen G, 2018, NEURON, V100, P1292, DOI 10.1016/j.neuron.2018.11.009
   Chen ZY, 2015, EUR J PAIN, V19, P176, DOI 10.1002/ejp.534
   Echeverry S, 2017, PAIN, V158, P1792, DOI 10.1097/j.pain.0000000000000982
   Edvinsson L, 2019, NAT REV NEUROL, V15, P483, DOI 10.1038/s41582-019-0216-y
   Erdener SE, 2021, J HEADACHE PAIN, V22, DOI 10.1186/s10194-021-01353-0
   Fried NT, 2018, CEPHALALGIA, V38, P674, DOI 10.1177/0333102417703764
   GILMORE SA, 1975, ANAT REC, V181, P799, DOI 10.1002/ar.1091810411
   Gong QY, 2020, NEUROSCIENCE, V451, P207, DOI 10.1016/j.neuroscience.2020.10.019
   Han X, 2017, MOL PAIN, V13, DOI 10.1177/1744806917720361
   He W, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1459-7
   Irmak DK, 2019, FRONT CELL NEUROSCI, V13, DOI 10.3389/fncel.2019.00136
   Jack CS, 2005, J IMMUNOL, V175, P4320, DOI 10.4049/jimmunol.175.7.4320
   Ji RR, 2018, ANESTHESIOLOGY, V129, P343, DOI 10.1097/ALN.0000000000002130
   Kawasaki Y, 2008, J NEUROSCI, V28, P5189, DOI 10.1523/JNEUROSCI.3338-07.2008
   Lai HC, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6173412
   Latremoliere A, 2009, J PAIN, V10, P895, DOI 10.1016/j.jpain.2009.06.012
   Lin JJ, 2015, SCI REP-UK, V5, DOI 10.1038/srep12549
   Liu CY, 2018, MOL PAIN, V14, DOI 10.1177/1744806918795930
   Liu L, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.668616
   Liu L, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1846296
   Liu SB, 2021, NATURE, V598, P641, DOI 10.1038/s41586-021-04001-4
   Liu SB, 2020, NEURON, V108, P436, DOI 10.1016/j.neuron.2020.07.015
   Long T, 2020, J HEADACHE PAIN, V21, DOI 10.1186/s10194-019-1070-4
   Long T, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1285-3
   Louter MA, 2013, BRAIN, V136, P3489, DOI 10.1093/brain/awt251
   MaassenVandenBrink A, 2018, GENOME MED, V10, DOI 10.1186/s13073-018-0524-7
   Malhotra R, 2016, ANN INDIAN ACAD NEUR, V19, P175, DOI 10.4103/0972-2327.182302
   Martami F, 2018, NEUROL SCI, V39, P1741, DOI 10.1007/s10072-018-3493-0
   McDonald JL, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/975632
   Melo-Carrillo A, 2013, CEPHALALGIA, V33, P1096, DOI 10.1177/0333102413486320
   Noseda R, 2013, PAIN, V154, pS44, DOI 10.1016/j.pain.2013.07.021
   Oliveira AB, 2017, J NEUROIMMUNOL, V313, P138, DOI 10.1016/j.jneuroim.2017.09.008
   Oshinsky ML, 2007, HEADACHE, V47, P1026, DOI 10.1111/j.1526-4610.2007.00871.x
   Pei P, 2019, ACUPUNCT MED, V37, P47, DOI 10.1136/acupmed-2017-011410
   Pei P, 2016, ACUPUNCT MED, V34, P127, DOI 10.1136/acupmed-2015-010840
   Qu ZY, 2020, J PAIN RES, V13, P25, DOI 10.2147/JPR.S226922
   Rahimifard M, 2017, AGEING RES REV, V36, P11, DOI 10.1016/j.arr.2017.02.004
   Riesco N, 2017, CURR PAIN HEADACHE R, V21, DOI 10.1007/s11916-017-0618-8
   Rinne M, 2020, EUR J PHARM SCI, V154, DOI 10.1016/j.ejps.2020.105493
   Rua R, 2018, TRENDS MOL MED, V24, P542, DOI 10.1016/j.molmed.2018.04.003
   Russo AF, 2015, ANNU REV PHARMACOL, V55, P533, DOI 10.1146/annurev-pharmtox-010814-124701
   Strassman AM, 1996, NATURE, V384, P560, DOI 10.1038/384560a0
   Su M, 2018, MOL PAIN, V14, DOI 10.1177/1744806918754612
   Su M, 2016, EUR J NEUROSCI, V44, P2129, DOI 10.1111/ejn.13296
   VOS BP, 1994, J NEUROSCI, V14, P2708
   Wang FZ, 2015, NEUROL SCI, V36, P535, DOI 10.1007/s10072-014-2010-3
   Wang L, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8253904
   Wang Y, 2018, CELL PHYSIOL BIOCHEM, V46, P568, DOI 10.1159/000488624
   Wieseler J, 2017, BRAIN RES, V1664, P87, DOI 10.1016/j.brainres.2017.03.011
   Woolf CJ, 2000, SCIENCE, V288, P1765, DOI 10.1126/science.288.5472.1765
   Wu BX, 2017, J MOL NEUROSCI, V63, P131, DOI 10.1007/s12031-017-0960-7
   Xie LS, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.689629
   Xie LS, 2020, AGING-US, V12, P22538, DOI 10.18632/aging.103663
   Xu XB, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/9512875
   Zhang JW, 2019, MOL IMMUNOL, V116, P29, DOI 10.1016/j.molimm.2019.09.020
   Zhang NS, 2020, HEADACHE, V60, P309, DOI 10.1111/head.13723
   Zhao L, 2017, JAMA INTERN MED, V177, P508, DOI 10.1001/jamainternmed.2016.9378
   Zhao LP, 2020, J PAIN RES, V13, P75, DOI 10.2147/JPR.S225431
   Zhu HT, 2014, J NEUROINFLAMM, V11, DOI 10.1186/1742-2094-11-59
   ZIMMERMANN M, 1983, PAIN, V16, P109, DOI 10.1016/0304-3959(83)90201-4
   Zusso M, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1538-9
NR 73
TC 17
Z9 18
U1 1
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD APR
PY 2023
VL 13
IS 4
AR 541
DI 10.3390/brainsci13040541
PG 23
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA F0BS5
UT WOS:000979093900001
PM 37190506
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ondrejkovicová, A
   Petrovics, G
   Svitková, K
   Balogh, V
AF Ondrejkovicova, Alena
   Petrovics, Gabriel
   Svitkova, Katarina
   Balogh, Vladimir
TI Is non-pharmacological treatment an effective option for chronic low
   back pain?
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE chronic low back pain; acupuncture; pain treatment
ID ACUPUNCTURE; COST; TRIAL
AB OBJECTIVE: Despite of pain being important warning signal for body ability to respond to internal or external threats, chronic pain is perceived as a discomfort by patients, leading to somatic, emotional and social negative changes. Lifestyle, wrong seating habits and some occupations may contribute to chronic back pain. Therapy for chronic back pain should include not only pharmacological or invasive interventions, but mostly change of lifestyle, physiotherapy and non-pharmacological methods.
   METHODS: The main objective of the paper was to compare subjective perception of the effectiveness of various methods for treatment of low back pain. In total, 100 patients were asked to fill the questionnaire after completing the treatment, whether conventional or non-pharmacological. We have aimed to analyze not only the perception of the patients, but also indicators of the patient's lifestyle, their nutrition and physical activity.
   RESULTS: Oral drugs was the most effective option perceived by the patients, followed by non-pharmacological methods, such as massages, heat application and acupuncture. At the same time, all patients who changed their lifestyle, for example reduced smoking and alcohol and increased physical activity, achieved better results in non-pharmacological treatment and experienced higher pain alleviation compared to the patients treated by medications only.
   CONCLUSION: Non-pharmacological therapy of chronic non-malignant low back pain could be an effective option offered in combination with medicaments and change of lifestyle.
C1 [Ondrejkovicova, Alena; Petrovics, Gabriel; Svitkova, Katarina; Balogh, Vladimir] Slovak Med Univ Bratislava, Fac Med, Inst Tradit Chinese Med, Dept Acupuncture, Bratislava, Slovakia.
C3 Slovak Medical University Bratislava; Comenius University Bratislava
RP Ondrejkovicová, A (corresponding author), Slovak Med Univ Bratislava, Fak Med, Inst Tradit Med, Dept Acupuncture, Limbova 12, Bratislava 83303, Slovakia.
EM aondrejk@hotmail.com
OI Petrovics, Gyorgy/0000-0003-3732-284X
CR Balogh V, 2001, 21 CONGR AC SLOV BOH, P5
   Cherkin DC, 2009, ARCH INTERN MED, V169, P858, DOI 10.1001/archinternmed.2009.65
   Cherkin DC, 2003, ANN INTERN MED, V138, P898, DOI 10.7326/0003-4819-138-11-200306030-00011
   Dagenais S, 2008, SPINE J, V8, P8, DOI 10.1016/j.spinee.2007.10.005
   Enthoven WTM, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012087
   Fiala P, 2016, AKUPUNKTURA VE 21 ST
   Haake M, 2007, ARCH INTERN MED, V167, P1892, DOI 10.1001/archinte.167.17.1892
   Hoy D, 2012, ARTHRITIS RHEUM-US, V64, P2028, DOI 10.1002/art.34347
   HUSKISSON EC, 1974, LANCET, V2, P1127, DOI 10.1016/S0140-6736(74)90884-8
   Martin BI, 2008, JAMA-J AM MED ASSOC, V299, P656, DOI 10.1001/jama.299.6.656
   Masar O, 2013, ANALGEZA SEDACIA URG
   Ondrejkovicová A, 2016, NEUROENDOCRINOL LETT, V37, P163
   Stewart WF, 2003, JAMA-J AM MED ASSOC, V290, P2443, DOI 10.1001/jama.290.18.2443
   Thomas KJ, 2005, HEALTH TECHNOL ASSES, V9, pIII
   Torp S, 2001, J OCCUP ENVIRON MED, V43, P120, DOI 10.1097/00043764-200102000-00010
NR 15
TC 5
Z9 5
U1 0
U2 10
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2017
VL 38
IS 3
BP 169
EP 172
PG 4
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA FC2TB
UT WOS:000406690100007
PM 28759184
DA 2026-01-16
ER

PT J
AU Prinsloo, S
   Rosenthal, DI
   Garcia, MK
   Meng, ZQ
   Cohen, L
AF Prinsloo, Sarah
   Rosenthal, David, I
   Garcia, Mary Kay
   Meng, Zhiqiang
   Cohen, Lorenzo
TI Cross-Cultural Brain Activity Differences Between True and Sham
   Acupuncture for Xerostomia During Head and Neck Cancer Radiotherapy
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE placebo; acupuncture; EEG; culture; xerostomia; cancer; radiation
ID RADIATION-INDUCED XEROSTOMIA; RESOLUTION ELECTROMAGNETIC TOMOGRAPHY;
   PLACEBO ACUPUNCTURE; RANDOMIZED-TRIAL; BACK-PAIN; EEG; LOCALIZATION;
   SENSATION; CONTEXTS; LORETA
AB Background: A prior phase III, multicenter (United States and China), clinical trial found true acupuncture (TA) resulted in lower xerostomia scores 12 months after radiotherapy than that of a standard care control group. This small pilot study examined brain function changes comparing TA to sham acupuncture (SA) in US and Fudan patients undergoing head and neck radiotherapy. Methods: To determine cerebral activity during TA versus SA acupuncture, patients underwent electroencephalogram evaluation (EEG) immediately prior, during and after both conditions. Acupuncture occurred during weeks 3 to 5 of radiotherapy, with patients receiving either TA or SA, followed 2 to 3 days later by the other treatment in a counterbalanced manner. Results: In the TA minus SA condition (N = 14 Fudan; N = 13 US), most changes were in the delta (0.5-3.5 Hz) and alpha (8-12 Hz) bandwidths. Delta was present in the frontal gyrus and parahippocampal gyrus. Alpha was present in the anterior and posterior cingulate, lingual gyrus, amygdala, precuneus, medial frontal gyrus, fusiform gyrus, and superior frontal gyrus. Maximal cortical differences in the Fudan cohort between TA and SA were in areas previously shown to be associated with (TA). In the US cohort, maximal differences between TA and SA were associated with areas which are usually decreased in TA conditions. Conclusions: There were distinct differences in brain function between those receiving TA and SA and there were clear differences between cultures, helping to explain the lack of placebo effect in the Fudan participants and strong placebo effect in the US patients.
C1 [Prinsloo, Sarah; Rosenthal, David, I; Garcia, Mary Kay; Cohen, Lorenzo] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Meng, Zhiqiang] Fudan Univ, Shanghai Canc Ctr, Shanghai, Peoples R China.
C3 University of Texas System; UTMD Anderson Cancer Center; Fudan
   University
RP Prinsloo, S (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, 1515 Holcombe Blvd,Unit 1414,FCT5-6006, Houston, TX 77030 USA.
EM SPrinsloo@MDAnderson.org
RI Meng, Zhiqiang/ABE-7747-2021
FU United States National Cancer Institute (NCI) [CA148707]; NCI Cancer
   Center Support Grant [CA016672]; Richard E. Haynes Distinguished
   Professorship for Clinical Cancer Prevention at The University of Texas
   MD Anderson Cancer Center; National Center for Complementary and
   Integrative Health [1K01AT008485-01]; Rising Tide Foundation; American
   Cancer Society
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Support
   was provided in part by United States National Cancer Institute (NCI)
   grants CA148707 (PI: L Cohen) and the NCI Cancer Center Support Grant
   CA016672. Partial funding provided by the Richard E. Haynes
   Distinguished Professorship for Clinical Cancer Prevention at The
   University of Texas MD Anderson Cancer Center (L Cohen). Financial
   support agencies for this project had no role in the design or
   interpretation of the data. Partial funding was provided by the National
   Center for Complementary and Integrative Health (1K01AT008485-01; PI: S
   Prinsloo), the Rising Tide Foundation (S Prinsloo) and The American
   Cancer Society (S Prinsloo).
CR Alahmadi N, 2016, FRONT HUM NEUROSCI, V10, DOI 10.3389/fnhum.2016.00559
   Asghar AU, 2010, BRAIN RES, V1315, P111, DOI 10.1016/j.brainres.2009.12.019
   Bai LJ, 2010, MOL PAIN, V6, DOI 10.1186/1744-8069-6-73
   Bertram U., 1967, Acta Odontol Scand, V25, P1
   Blom M, 1996, ORAL ONCOL, V32B, P182
   Cherkin DC, 2009, ARCH INTERN MED, V169, P858, DOI 10.1001/archinternmed.2009.65
   Congedo M, 2004, IEEE T NEUR SYS REH, V12, P387, DOI 10.1109/TNSRE.2004.840492
   Deng G, 2008, BMC COMPLEM ALTERN M, V8, DOI 10.1186/1472-6882-8-37
   Dierks T, 2000, CLIN NEUROPHYSIOL, V111, P1817, DOI 10.1016/S1388-2457(00)00427-2
   Enblom A, 2012, ANN ONCOL, V23, P1353, DOI 10.1093/annonc/mdr402
   Garcia MK, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.16910
   Haake M, 2007, ARCH INTERN MED, V167, P1892, DOI 10.1001/archinte.167.17.1892
   Han SH, 2014, NEUROIMAGE, V99, P293, DOI 10.1016/j.neuroimage.2014.05.062
   Harris RE, 2009, NEUROIMAGE, V47, P1077, DOI 10.1016/j.neuroimage.2009.05.083
   Hedden T, 2008, PSYCHOL SCI, V19, P12, DOI 10.1111/j.1467-9280.2008.02038.x
   Huang WJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032960
   Humbert IA, 2009, NEUROIMAGE, V44, P982, DOI 10.1016/j.neuroimage.2008.10.012
   Jensen MP, 2008, J PAIN, V9, P193, DOI 10.1016/j.jpain.2007.11.003
   Kong J, 2009, NEUROIMAGE, V47, P1066, DOI 10.1016/j.neuroimage.2009.05.087
   Li CF, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097502
   Li LX, 2016, CHIN J INTEGR MED, V22, P549, DOI 10.1007/s11655-015-2145-y
   Li N, 2008, IEEE ENG MED BIO, P1108, DOI 10.1109/IEMBS.2008.4649354
   Madsen MV, 2009, BMJ-BRIT MED J, V338, DOI 10.1136/bmj.a3115
   Malallah OS, 2018, INT J PHARMACEUT, V541, P157, DOI 10.1016/j.ijpharm.2018.02.004
   Manheimer E, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005111.pub3
   McDowell LJ, 2018, INT J RADIAT ONCOL, V102, P340, DOI 10.1016/j.ijrobp.2018.05.060
   Meng ZQ, 2012, CANCER-AM CANCER SOC, V118, P3337, DOI 10.1002/cncr.26550
   MOSS EM, 1985, NEUROPSYCHOLOGIA, V23, P131, DOI 10.1016/0028-3932(85)90054-5
   Mu Y, 2015, P NATL ACAD SCI USA, V112, P15348, DOI 10.1073/pnas.1509839112
   Mulert C, 2004, NEUROIMAGE, V22, P83, DOI 10.1016/j.neuroimage.2003.10.051
   Park Jongbae, 2002, Acupunct Med, V20, P168
   Park JJ, 2009, ACUPUNCT MED, V27, P93, DOI 10.1136/aim.2009.001495
   Prinsloo S, 2018, INT C INT MED HLTH M
   Sakai S, 2007, AUTON NEUROSCI-BASIC, V133, P158, DOI 10.1016/j.autneu.2007.01.001
   Sakatani K, 2010, ADV EXP MED BIOL, V662, P455, DOI 10.1007/978-1-4419-1241-1_65
   Shi GX, 2012, TRIALS, V13, DOI 10.1186/1745-6215-13-42
   Simcock R, 2013, ANN ONCOL, V24, P776, DOI 10.1093/annonc/mds515
   Streitberger K, 2008, J ALTERN COMPLEM MED, V14, P505, DOI 10.1089/acm.2007.0552
   Suzuki M, 2012, ARCH INTERN MED, V172, P878, DOI 10.1001/archinternmed.2012.1233
   Thatcher RW, 2012, HUM BRAIN MAPP, V33, P1062, DOI 10.1002/hbm.21271
   Tsao GJ, 2015, LARYNGOSCOPE, V125, P1972, DOI 10.1002/lary.25252
   Vitacco D, 2002, HUM BRAIN MAPP, V17, P4, DOI 10.1002/hbm.10038
   Volinn E, 2013, J ALTERN COMPLEM MED, V19, P435, DOI 10.1089/acm.2010.0786
   Wang K, 2014, NEUROREPORT, V25, P656, DOI 10.1097/WNR.0000000000000152
   Wang Y, 2014, NEUROREPORT, V25, P110, DOI 10.1097/WNR.0000000000000077
   Worrell GA, 2000, BRAIN TOPOGR, V12, P273, DOI 10.1023/A:1023407521772
   Wymbs NF, 2015, CEREB CORTEX, V25, P4213, DOI 10.1093/cercor/bhu144
   Yi GS, 2013, COGN NEURODYNAMICS, V7, P79, DOI 10.1007/s11571-012-9221-1
   Yu HT, 2018, IEEE T NEUR SYS REH, V26, P977, DOI 10.1109/TNSRE.2018.2828143
   Zhao L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099538
   Zumsteg D, 2005, NEUROLOGY, V65, P1657, DOI 10.1212/01.wnl.0000184516.32369.1a
   Zumsteg D, 2006, CLIN NEUROPHYSIOL, V117, P1602, DOI 10.1016/j.clinph.2006.04.008
NR 52
TC 2
Z9 2
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD MAY
PY 2022
VL 21
AR 15347354221101630
DI 10.1177/15347354221101630
PG 9
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA 1M8DM
UT WOS:000800196100001
PM 35603438
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU MacPherson, H
   Tilbrook, HE
   Richmond, SJ
   Atkin, K
   Ballard, K
   Bland, M
   Eldred, J
   Essex, HN
   Hopton, A
   Lansdown, H
   Muhammad, U
   Parrott, S
   Torgerson, D
   Wenham, A
   Woodman, J
   Watt, I
AF MacPherson, Hugh
   Tilbrook, Helen E.
   Richmond, Stewart J.
   Atkin, Karl
   Ballard, Kathleen
   Bland, Martin
   Eldred, Janet
   Essex, Holly N.
   Hopton, Ann
   Lansdown, Harriet
   Muhammad, Usman
   Parrott, Steve
   Torgerson, David
   Wenham, Aniela
   Woodman, Julia
   Watt, Ian
TI Alexander Technique Lessons, Acupuncture Sessions or usual care for
   patients with chronic neck pain (ATLAS): study protocol for a randomised
   controlled trial
SO TRIALS
LA English
DT Article
ID BACK-PAIN; INITIAL VALIDATION; COST-EFFECTIVENESS; COGNITIVE-FACTORS;
   CHRONIC HEADACHE; MASSAGE ATEAM; EXERCISE; DISABILITY; OUTCOMES; WORK
AB Background: Chronic neck pain is a common condition in the adult population. More research is needed to evaluate interventions aiming to facilitate beneficial long-term change. We propose to evaluate the effect of Alexander Technique lessons and acupuncture in a rigorously conducted pragmatic trial with an embedded qualitative study.
   Methods/Design: We will recruit 500 patients who have been diagnosed with neck pain in primary care, who have continued to experience neck pain for at least three months with 28% minimum cut-off score on the Northwick Park Neck Pain Questionnaire (NPQ). We will exclude patients with serious underlying pathology, prior cervical spine surgery, history of psychosis, rheumatoid arthritis, ankylosing spondylitis, osteoporosis, haemophilia, cancer, HIV or hepatitis, or with alcohol or drug dependency currently or in the last 12 months, or actively pursuing compensation or with pending litigation.
   The York Trials Unit will randomly allocate participants using a secure computer-based system. We will use block randomisation with allocation to each intervention arm being unambiguously concealed from anyone who might subvert the randomisation process.
   Participants will be randomised in equal proportions to Alexander Technique lessons, acupuncture or usual care alone. Twenty 30-minute Alexander Technique lessons will be provided by teachers registered with the Society of Teachers of the Alexander Technique and twelve 50-minute sessions of acupuncture will be provided by acupuncturists registered with the British Acupuncture Council. All participants will continue to receive usual GP care.
   The primary outcome will be the NPQ at 12 months, with the secondary time point at 6 months, and an area-undercurve analysis will include 3, 6 and 12 month time-points. Adverse events will be documented. Potential intervention effect modifiers and mediators to be explored include: self-efficacy, stress management, and the incorporation of practitioner advice about self-care and lifestyle. Qualitative material will be used to address issues of safety, acceptability and factors that impact on longer term outcomes.
   Discussion: This study will provide robust evidence on whether there are significant clinical benefits to patients, economic benefits demonstrating value for money, and sufficient levels of acceptability and safety.
C1 [MacPherson, Hugh; Tilbrook, Helen E.; Richmond, Stewart J.; Atkin, Karl; Bland, Martin; Eldred, Janet; Essex, Holly N.; Hopton, Ann; Lansdown, Harriet; Muhammad, Usman; Parrott, Steve; Torgerson, David; Wenham, Aniela; Woodman, Julia; Watt, Ian] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England.
   [Ballard, Kathleen; Woodman, Julia] Soc Teachers Alexander Tech, London NW5 1RS, England.
   [Watt, Ian] Univ York, Hull York Med Sch, York YO10 5DD, N Yorkshire, England.
C3 University of York - UK; University of York - UK; University of Hull
RP MacPherson, H (corresponding author), Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England.
EM hugh.macpherson@york.ac.uk
RI ; Torgerson, David/L-4566-2019
OI MacPherson, Hugh/0000-0003-4255-4768; Usman,
   Muhammad/0000-0002-0911-3277; Parrott, Steve/0000-0002-0165-1150; Atkin,
   Karl Michael/0000-0003-1070-8670; Eled, Janet/0000-0003-2858-8240;
   Torgerson, David/0000-0002-1667-4275
FU Arthritis Research UK [19702]; Arthritis Research UK's Musculoskeletal
   Pain Clinic Studies Group; Cancer Research UK; Versus Arthritis [19702]
   Funding Source: researchfish
FX The ATLAS trial has been funded by Arthritis Research UK, grant
   reference: Grant Ref 19702. The funding body had some involvement, via
   Arthritis Research UK's Musculoskeletal Pain Clinic Studies Group, in
   developing the original design of the study prior to providing the
   grant. The funding body has no input into the collection, analysis, and
   interpretation of data; in the writing of the manuscript; nor in the
   decision to submit the manuscript for publication.
CR ANDERSON KO, 1995, PAIN, V63, P77, DOI 10.1016/0304-3959(95)00021-J
   [Anonymous], GUID METH TECHN APPR
   Bakker AB, 2008, J VOCAT BEHAV, V72, P400, DOI 10.1016/j.jvb.2007.11.007
   Binder AI, 2007, BMJ-BRIT MED J, V334, P527, DOI 10.1136/bmj.39127.608299.80
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Dziedzic K, 2005, ARTHRIT RHEUM-ARTHR, V53, P214, DOI 10.1002/art.21087
   Ferrari R, 2003, BEST PRACT RES CL RH, V17, P57, DOI 10.1016/S1521-6942(02)00097-9
   Gross A, 2010, MANUAL THER, V15, P315, DOI 10.1016/j.math.2010.04.002
   Gustavsson C, 2010, EUR J PAIN, V14, DOI 10.1016/j.ejpain.2009.10.004
   Hewitt CE, 2006, CAN MED ASSOC J, V175, P347, DOI 10.1503/cmaj.051625
   Hollinghurst Sandra, 2008, BMJ, V337, pa2656, DOI 10.1136/bmj.a2656
   HOUTMAN ILD, 1994, SCAND J WORK ENV HEA, V20, P139, DOI 10.5271/sjweh.1419
   Hsu C, 2010, J ALTERN COMPLEM MED, V16, P157, DOI 10.1089/acm.2009.0188
   Hurwitz EL, 2006, DISABIL REHABIL, V28, P1319, DOI 10.1080/09638280600641509
   Jones F.P., 1997, FREEDOM CHANGE DEV S, V3rd
   Kind P., 1996, QUALITY LIFE PHARMAC, V2, P191
   Korhonen T, 2003, OCCUP ENVIRON MED, V60, P475, DOI 10.1136/oem.60.7.475
   LEAK AM, 1994, BRIT J RHEUMATOL, V33, P469
   Linton JS, 2000, EUR J PAIN-LONDON, V4, P347, DOI 10.1053/eujp.2000.0190
   Little P, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a884
   Maciocia Giovanni., 1989, FDN CHINESE MED
   MacPherscon H, 2008, COMPLEMENT THER MED, V16, P101, DOI 10.1016/j.ctim.2008.02.010
   MacPherson H, 2004, QUAL SAF HEALTH CARE, V13, P349, DOI 10.1136/qshc.2003.009134
   MacPherson H, 2001, BMJ-BRIT MED J, V323, P486, DOI 10.1136/bmj.323.7311.486
   MacPherson H, 2012, TRIALS, V13, DOI 10.1186/1745-6215-13-209
   MacPherson H, 2010, BMC GASTROENTEROL, V10, DOI 10.1186/1471-230X-10-63
   Mitchell AM, 2008, RES NURS HEALTH, V31, P576, DOI 10.1002/nur.20284
   Moffett JAK, 2005, BRIT MED J, V330, P75, DOI 10.1136/bmj.38286.493206.82
   Moffett JK, 2006, RHEUMATOLOGY OXFORD, V45, P1514
   National Collaborating Centre for Mental Health, NICE GUID TREATM MAN, P1
   National Institute for Health and Clincal Excellence, 2009, LOW BACK PAIN EARL M
   Paterson C, 2005, BMJ-BRIT MED J, V330, P1202, DOI 10.1136/bmj.330.7501.1202
   Ratcliffe J, 2006, BRIT MED J, V333, P626, DOI 10.1136/bmj.38932.806134.7C
   Salter GC, 2006, BMC MUSCULOSKEL DIS, V7, DOI 10.1186/1471-2474-7-99
   Thomas KJ, 2006, BMJ-BRIT MED J, V333, P623, DOI 10.1136/bmj.38878.907361.7C
   Thompson DP, 2010, DISABIL REHABIL, V32, P1758, DOI 10.3109/09638281003734342
   Torgerson D, 1999, BMJ-BRIT MED J, V318, P1413, DOI 10.1136/bmj.318.7195.1413
   Trinh KV, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004870.pub3
   Vickers AJ, 2004, BRIT MED J, V328, P744, DOI 10.1136/bmj.38029.421863.EB
   Ware JE, 1996, MED CARE, V34, P220, DOI 10.1097/00005650-199603000-00003
   Willich SN, 2006, PAIN, V125, P107, DOI 10.1016/j.pain.2006.06.006
   Witt CM, 2006, PAIN, V125, P98, DOI 10.1016/j.pain.2006.05.013
   Woby SR, 2007, EUR J PAIN, V11, P869, DOI 10.1016/j.ejpain.2007.01.005
   Wonderling D, 2004, BMJ-BRIT MED J, V328, P747, DOI 10.1136/bmj.38033.896505.EB
   Yardley L, 2010, FAM PRACT, V27, P198, DOI 10.1093/fampra/cmp093
NR 45
TC 18
Z9 18
U1 1
U2 61
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUL 10
PY 2013
VL 14
AR 209
DI 10.1186/1745-6215-14-209
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 187OJ
UT WOS:000322128100001
PM 23841901
OA Green Accepted, Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Cho, E
   Park, CH
   Cho, SY
AF Cho, Eunae
   Park, Chang-Hwan
   Cho, Seo Yeon
TI Single balloon enteroscopy-guided endoscopic retrograde pancreatography
   for the treatment of a symptomatic pancreatic pseudocyst complicated by
   pancreaticojejunostomy stricture: A case report
SO MEDICINE
LA English
DT Article
DE altered gastrointestinal anatomy; case report; endoscopic retrograde;
   enteroscopy; pancreatic pseudocyst; pancreatography
ID ASSISTED ENTEROSCOPY; CHOLANGIOPANCREATOGRAPHY; DRAINAGE;
   PANCREATICODUODENECTOMY; MULTICENTER; EXPERIENCE; ERCP
AB Rationale: Endoscopic treatment of a pancreatic pseudocyst complicated by pancreaticojejunostomy (PJ) stricture is challenging. Patient concerns: A 76-year-old woman presented with worsening abdominal pain and dyspepsia. She had been receiving adjuvant chemotherapy (capecitabine and cisplatin) for 4 months after pylorus-preserving pancreaticoduodenectomy (PPPD) for the treatment of extrahepatic cholangiocarcinoma. Diagnoses: Laboratory findings included elevated serum amylase (145 U/L) and lipase (437 U/L) levels. Abdominal computed tomography (CT) showed a pancreatic pseudocyst of approximately 3 cm in size and pancreatic duct dilatation in the remnant pancreas. According to the Response Evaluation Criteria in Solid Tumors, cholangiocarcinoma is a stable disease. Interventions and outcomes: Endoscopic drainage of the pancreatic pseudocyst was planned. Single-balloon enteroscopy (SBE)-guided endoscopic retrograde pancreatography (ERP) with endoscopic ultrasonography (EUS) using a mini probe demonstrated a membranous PJ stricture and a pancreatic pseudocyst. Endoscopic pseudocyst drainage using a 7-Fr plastic stent was successfully performed after needle-knife incision of the PJ stricture. Follow-up abdominal CT after 3 weeks showed complete resolution of the pseudocyst. Chemotherapy was resumed. Lessons: SBE-guided ERP with EUS using a mini probe may be an effective and safe treatment in a patient with a pancreatic pseudocyst complicated by membranous PJ stricture after PPPD.
C1 [Cho, Eunae; Park, Chang-Hwan; Cho, Seo Yeon] Chonnam Natl Univ, Dept Internal Med, Div Gastroenterol, Sch Med, Gwangju, South Korea.
C3 Chonnam National University
RP Park, CH (corresponding author), Chonnam Natl Univ Hosp, Dept Internal Med, Div Gastroentero, 42 Jebong Ro, Gwangju, South Korea.
EM p1052ccy@hanmail.net
OI Cho, Eunae/0000-0001-5931-4643
FU Chonnam National University Hospital Biomedical Research Institute
   [BCRI22067]
FX This study was supported by a grant (BCRI22067) of Chonnam National
   University Hospital Biomedical Research Institute.
CR Basiliya K, 2021, ENDOSCOPY, V53, P266, DOI 10.1055/a-1200-0199
   Benson AB III, 2021, J NATL COMPR CANC NE, V19, P541, DOI 10.6004/jnccn.2021.0022
   Chahal P, 2006, ENDOSCOPY, V38, P1241, DOI 10.1055/s-2006-945003
   Chen YI, 2017, GASTROINTEST ENDOSC, V85, P170, DOI 10.1016/j.gie.2016.07.031
   Demirjian AN, 2010, HPB, V12, P482, DOI 10.1111/j.1477-2574.2010.00214.x
   Fujii LL, 2013, GASTROINTEST ENDOSC, V78, P854, DOI 10.1016/j.gie.2013.05.016
   Ghazanfar MA, 2018, ANZ J SURG, V88, P626, DOI 10.1111/ans.14073
   Itoi T, 2013, DIGEST ENDOSC, V25, P241, DOI 10.1111/den.12048
   Itokawa F, 2014, DIGEST ENDOSC, V26, P136, DOI 10.1111/den.12254
   Krutsri C, 2019, WORLD J GASTROENTERO, V25, P3313, DOI 10.3748/wjg.v25.i26.3313
   Matsumoto I, 2022, ANN GASTROENT SURG, V6, P412, DOI 10.1002/ags3.12528
   Morgan KA, 2010, HPB, V12, P211, DOI 10.1111/j.1477-2574.2009.00154.x
   Muthusamy VR, 2016, GASTROINTEST ENDOSC, V83, P481, DOI 10.1016/j.gie.2015.11.027
   Nabeshima T, 2018, INTERNAL MED, V57, P357, DOI 10.2169/internalmedicine.9133-17
   Oh CH, 2021, CLIN ENDOSC, V54, P505, DOI 10.5946/ce.2021.185
   Park BK, 2016, DIGEST DIS SCI, V61, P293, DOI 10.1007/s10620-015-3861-z
   Schneider M, 2019, WORLD J GASTROENTERO, V25, P3538, DOI 10.3748/wjg.v25.i27.3538
   Shah RJ, 2013, GASTROINTEST ENDOSC, V77, P593, DOI 10.1016/j.gie.2012.10.015
   van der Merwe SW, 2022, ENDOSCOPY, V54, P185, DOI 10.1055/a-1717-1391
   Vila JJ, 2010, WORLD J GASTRO ENDOS, V2, P193, DOI 10.4253/wjge.v2.i6.193
   Yane K, 2017, ENDOSCOPY, V49, P69, DOI 10.1055/s-0042-118301
NR 21
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 28
PY 2022
VL 101
IS 43
AR e31293
DI 10.1097/MD.0000000000031293
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5V5UQ
UT WOS:000877294300069
PM 36316922
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Argenbright, CA
   Taylor-Piliae, RE
   Loescher, LJ
AF Argenbright, Christine A.
   Taylor-Piliae, Ruth E.
   Loescher, Lois J.
TI Bowenwork for symptom management of women breast cancer survivors with
   lymphedema: A pilot study
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Article
DE Breast neoplasms; Lymphedema; Musculoskeletal manipulations;
   Complementary
ID QUALITY-OF-LIFE; MANUAL LYMPHATIC DRAINAGE; ALTERNATIVE MEDICINE; ARM
   LYMPHEDEMA; THERAPY; COMPLEMENTARY; IMPACT; FEASIBILITY; ACUPUNCTURE;
   TRIAL
AB Purpose: The objectives of this pilot study for women breast cancer survivors with lymphedema was 1) to evaluate recruitment rates, retention rates, adherence to Bowenwork (a noninvasive complementary therapy involving gentle muscle movements), home exercises, safety and comfort; 2) determine the effect of Bowenwork on quality of life (QOL), functional status, perceived pain, range of motion (ROM), arm/ankle circumference (to assess for localized and systemic changes).
   Methods: Participants received 4 Bowenwork sessions with home exercises. Initial and post assessments included QOL, functional status, and pain. ROM, arm/ankle circumference and pain measures were recorded before each session.
   Results: Twenty-one women enrolled in the study; 95% completion; adherence 100%; home exercises 95%; no adverse events. The intervention improved mental health (SF-36-MCS); breast cancer-related functional (FACT-B); increased ROM; reduced arm circumferences. P value set at <0.05.
   Conclusions: The Bowenwork intervention was safe and acceptable for women breast cancer survivors with lymphedema. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Argenbright, Christine A.] James Madison Univ, Sch Nursing, Harrisonburg, VA 22807 USA.
   [Taylor-Piliae, Ruth E.; Loescher, Lois J.] Univ Arizona, Coll Nursing, Tucson, AZ 85721 USA.
C3 James Madison University; University of Arizona
RP Argenbright, CA (corresponding author), James Madison Univ, Sch Nursing, Harrisonburg, VA 22807 USA.
CR Acebedo JC, 2015, Practice Nursing, V26, P79, DOI [10.12968/pnur.2015.26.2.79, DOI 10.12968/PNUR.2015.26.2.79]
   Amato D., 2001, ADV PHYS THERAPIST P, V12, P208
   [Anonymous], 2015, Breast Cancer Facts Figures 2015-2016
   Armer JM, 2010, LYMPHOLOGY, V43, P118
   Armer JM, 2010, CANCER EPIDEM BIOMAR, V19, P2715, DOI 10.1158/1055-9965.EPI-10-0962
   Armer JM, 2005, CANCER INVEST, V23, P76, DOI 10.1081/CNV-200048707
   Armer JM, 2004, LYMPHOLOGY, V37, P73
   Balci FL, 2012, TOP GERIATR REHABIL, V28, P243, DOI 10.1097/TGR.0b013e3182566eb2
   Brady MJ, 1997, J CLIN ONCOL, V15, P974, DOI 10.1200/JCO.1997.15.3.974
   Chan DNS, 2010, J ADV NURS, V66, P1902, DOI 10.1111/j.1365-2648.2010.05374.x
   Chang Christine J, 2013, Semin Oncol Nurs, V29, P28, DOI 10.1016/j.soncn.2012.11.005
   Cheville AL, 2010, CANCER-AM CANCER SOC, V116, P3722, DOI 10.1002/cncr.25068
   DAUT RL, 1983, PAIN, V17, P197, DOI 10.1016/0304-3959(83)90143-4
   de Valois BA, 2012, EUR J ONCOL NURS, V16, P301, DOI 10.1016/j.ejon.2011.07.005
   Dominick SA, 2014, PSYCHO-ONCOLOGY, V23, P1049, DOI 10.1002/pon.3510
   Finnane A, 2011, J ALTERN COMPLEM MED, V17, P867, DOI 10.1089/acm.2010.0456
   Fisher MI, 2014, J BODYW MOV THER, V18, P559, DOI 10.1016/j.jbmt.2014.02.006
   Fleysher Larisa A, 2010, Br J Nurs, V19, P826
   Hansen C, 2011, J ALTERN COMPLEM MED, V17, P1001, DOI 10.1089/acm.2010.0023
   Henneghan AM, 2015, J HOLIST NURS, V33, P84, DOI 10.1177/0898010114539191
   Huang TW, 2013, WORLD J SURG ONCOL, V11, DOI 10.1186/1477-7819-11-15
   Jeffs E, 2016, EUR J ONCOL NURS, V20, P173, DOI 10.1016/j.ejon.2015.08.001
   Lacomba MT, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.b5396
   Lacovara Jane E, 2006, Medsurg Nurs, V15, P302
   Loudon A, 2012, J LYMPHOEDEMA, V7, P27
   Loudon A, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-66
   Manheimer Eric, 2006, J Altern Complement Med, V12, P193, DOI 10.1089/acm.2006.12.193
   NLN M. A. C., 2011, DIAGNOSIS TREATMENT
   Pennington K, 2012, J AUST TRADIT-MED SO, V18, P217
   Ridner SH, 2005, SUPPORT CARE CANCER, V13, P904, DOI 10.1007/s00520-005-0810-y
   Ridner SH, 2008, ONCOL NURS FORUM, V35, P57, DOI 10.1188/08.ONF.57-63
   Ridner SH, 2013, ONCOL NURS FORUM, V40, P383, DOI 10.1188/13.ONF.383-393
   Ridner SH, 2011, SUPPORT CARE CANCER, V19, P631, DOI 10.1007/s00520-010-0870-5
   Rodrick JR, 2014, PM&R, V6, P250, DOI 10.1016/j.pmrj.2013.09.008
   Shah C, 2012, BREAST J, V18, P357, DOI 10.1111/j.1524-4741.2012.01252.x
   Shapiro G., 2002, BOWEN TECHNIQUE FIBR
   Shapiro G., 2003, WEED WONDERINGS, V3
   Shapiro G., 2004, POSIT HLTH
   Shapiro G., 2004, Positive Health, P48
   Smith CA, 2014, ACUPUNCT MED, V32, P387, DOI 10.1136/acupmed-2014-010593
   SPSS Inc., 2010, PASW 18 0
   Stuiver MM, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009765.pub2
   Tsauo JY, 2011, SUPPORT CARE CANCER, V19, P599, DOI 10.1007/s00520-010-0857-2
   Wanchai Ausanee, 2013, Semin Oncol Nurs, V29, P41, DOI 10.1016/j.soncn.2012.11.006
   Wanchai A, 2010, CLIN J ONCOL NURS, V14, P431, DOI 10.1188/10.CJON.E45-E55
   Wanchai A, 2010, ONCOL NURS FORUM, V37, P494, DOI 10.1188/10.ONF.494-500
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
   Webster Kimberly, 2003, Health Qual Life Outcomes, V1, P79, DOI 10.1186/1477-7525-1-79
   Wilks J., 2012, J AUST TRADITINAL ME, V19, P33
NR 49
TC 4
Z9 6
U1 0
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD NOV
PY 2016
VL 25
BP 142
EP 149
DI 10.1016/j.ctcp.2016.09.004
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA ED8GV
UT WOS:000389110900019
PM 27863604
DA 2026-01-16
ER

PT J
AU Shafto, K
   Gouda, S
   Catrine, K
   Brown, ML
AF Shafto, Kate
   Gouda, Suzanne
   Catrine, Kris
   Brown, Melanie L.
TI Integrative Approaches in Pediatric Palliative Care
SO CHILDREN-BASEL
LA English
DT Article
DE pediatrics; palliative care; integrative medicine; symptom management;
   mind-body medicine; pain management; acupuncture; yoga
ID HEART-RATE-VARIABILITY; CONTROLLED-TRIAL; ALTERNATIVE MEDICINE;
   NERVE-STIMULATION; PAIN MANAGEMENT; CANCER-PATIENTS; MENTAL-HEALTH;
   ACUPUNCTURE; COMPLEMENTARY; CHILDREN
AB Pediatric palliative care is a field which focuses on caring for and treating the symptoms and distress typically associated with life-limiting illness. Integrative medicine is supported by evidence and aims to heal the whole person, including all aspects of one's lifestyle. Therapies offered by integrative medicine often empower patients and families, allowing for a sense of control. This review addresses the merging of integrative medicine philosophy and modalities with the care given to children with life-limiting illness. We review an introduction to integrative medicine, trends in its incorporation in the healthcare setting, application to patients receiving palliative care and the management of specific symptoms. A case study is offered to illustrate these principles.
C1 [Shafto, Kate] Univ Minnesota, Dept Internal Med & Pediat, Minneapolis, MN 55455 USA.
   [Gouda, Suzanne] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA.
   [Catrine, Kris; Brown, Melanie L.] Childrens Hosp & Clin Minnesota, Dept Pain Med Palliat Care & Integrat Med, Minneapolis, MN 55404 USA.
   [Brown, Melanie L.] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Chicago; Children's Hospitals & Clinics of Minnesota;
   University of Minnesota System; University of Minnesota Twin Cities
RP Brown, ML (corresponding author), Childrens Hosp & Clin Minnesota, Dept Pain Med Palliat Care & Integrat Med, Minneapolis, MN 55404 USA.; Brown, ML (corresponding author), Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA.
EM kshafto@umn.edu; suzanne.gouda@uchospitals.edu;
   kris.catrine@childrensmn.org; melanie.brown@childrensmn.org
RI Brown, Melanie/HGB-5161-2022
OI Brown, Melanie/0000-0002-3469-7729; Shafto,
   Katherine/0000-0002-3419-0514
FU Coleman Foundation; Oberweiler Foundation; Patient-Centered Outcomes
   Research Institute
FX In the past 5 years, M.L.B. has been supported in part by the Coleman
   Foundation, the Oberweiler Foundation and the Patient-Centered Outcomes
   Research Institute. The founding sponsors had no role in the design of
   the study; in the collection, analyses, or interpretation of data; in
   the writing of the manuscript, and in the decision to publish the
   results.
CR Adams D, 2011, PEDIATRICS, V128, pE1575, DOI 10.1542/peds.2011-1091
   Angold A, 1999, J CHILD PSYCHOL PSYC, V40, P57, DOI 10.1017/S0021963098003448
   [Anonymous], 2011, HERBAL MED BIOMOLECU, DOI 10.1201/b10787-8
   [Anonymous], PAIN RES TREAT, DOI DOI 10.1155/2016/8158693
   AVELLANOSA AM, 1982, J MED, V13, P203
   Barnes Patricia M, 2008, Natl Health Stat Report, P1
   BLAKE KD, 1993, LANCET, V341, P640, DOI 10.1016/0140-6736(93)90410-I
   Brown ML, 2017, CHILDREN-BASEL, V4, DOI 10.3390/children4060050
   Burden B, 2005, INT J PALLIAT NURS, V11, P248, DOI 10.12968/ijpn.2005.11.5.248
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Latorraca CDC, 2017, INT J CLIN PRACT, V71, DOI 10.1111/ijcp.13034
   Cryan JF, 2011, NEUROGASTROENT MOTIL, V23, P187, DOI 10.1111/j.1365-2982.2010.01664.x
   Deans E, 2016, J PHYSIOL ANTHROPOL, V36, DOI 10.1186/s40101-016-0101-y
   Deng G, 2005, CA-CANCER J CLIN, V55, P109, DOI 10.3322/canjclin.55.2.109
   Derry S, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007393.pub3
   Dupuis L Lee, 2003, Paediatr Drugs, V5, P597, DOI 10.2165/00148581-200305090-00003
   Ernst E, 2000, BRIT J ANAESTH, V84, P367, DOI 10.1093/oxfordjournals.bja.a013442
   Gadsby J.G., 1997, Complementary Ther Med, V5, P13, DOI [10.1016/S0965-2299(97)80084-2, DOI 10.1016/S0965-2299(97)80084-2]
   Goyal M, 2014, JAMA INTERN MED, V174, P357, DOI 10.1001/jamainternmed.2013.13018
   Hassett AL, 2007, APPL PSYCHOPHYS BIOF, V32, P1, DOI 10.1007/s10484-006-9028-0
   Hines S, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007598.pub2
   JAVORKA K, 1980, PHYSIOL BOHEMOSLOV, V29, P29
   Jindal V, 2008, J PEDIAT HEMATOL ONC, V30, P431, DOI 10.1097/MPH.0b013e318165b2cc
   JOBST K, 1986, LANCET, V2, P1416, DOI 10.1016/S0140-6736(86)92732-7
   Jorm AF, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007142.pub2
   Karatekin C, 2018, STRESS HEALTH, V34, P36, DOI 10.1002/smi.2761
   Karavidas MK, 2007, APPL PSYCHOPHYS BIOF, V32, P19, DOI 10.1007/s10484-006-9029-z
   Kazak AE, 1998, PEDIATRICS, V102, P59, DOI 10.1542/peds.102.1.59
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P617, DOI 10.1001/archpsyc.62.6.617
   KNAUS WA, 1995, JAMA-J AM MED ASSOC, V274, P1591, DOI 10.1001/jama.1995.03530200027032
   Lazar SW, 2000, NEUROREPORT, V11, P1581, DOI 10.1097/00001756-200005150-00041
   Lee A, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003281.pub4
   Lee MS, 2011, CHIN J INTEGR MED, V17, P187, DOI 10.1007/s11655-011-0665-7
   Lin YC, 2005, PAIN MED, V6, P452, DOI 10.1111/j.1526-4637.2005.00071.x
   Liossi C, 1999, INT J CLIN EXP HYP, V47, P104, DOI 10.1080/00207149908410025
   Malboeuf-Hurtubise C, 2016, J CHILD FAM STUD, V25, P1168, DOI 10.1007/s10826-015-0299-z
   Mason L, 2004, BMJ-BRIT MED J, V328, P991, DOI 10.1136/bmj.38042.506748.EE
   McClafferty H, 2016, PEDIATRICS, V138, DOI 10.1542/peds.2016-1896
   Nazareth M, 2016, PREV CHRONIC DIS, V13, DOI 10.5888/pcd13.160046
   O'Keeffe GS, 2011, PEDIATRICS, V127, P800, DOI 10.1542/peds.2011-0054
   O'Neil A, 2014, AM J PUBLIC HEALTH, V104, pE31, DOI 10.2105/AJPH.2014.302110
   OSTROWSKI MJ, 1979, BRIT J CLIN PRACT, V33, P157
   Pittig A, 2013, INT J PSYCHOPHYSIOL, V87, P19, DOI 10.1016/j.ijpsycho.2012.10.012
   Posadzki P, 2012, J PAIN SYMPTOM MANAG, V44, P95, DOI 10.1016/j.jpainsymman.2011.07.014
   Quimby EL, 2007, J PEDIATR ONCOL NURS, V24, P35, DOI 10.1177/1043454206296027
   Rahe C, 2014, EUR J NUTR, V53, P997, DOI 10.1007/s00394-014-0652-9
   RAINS C, 1995, DRUG AGING, V7, P317, DOI 10.2165/00002512-199507040-00007
   Rakel D., 2017, Integrative medicine, V4th
   Reibel DK, 2001, GEN HOSP PSYCHIAT, V23, P183, DOI 10.1016/S0163-8343(01)00149-9
   Rogers GB, 2016, MOL PSYCHIATR, V21, P738, DOI 10.1038/mp.2016.50
   Rome RB, 2011, OCHSNER J, V11, P348
   Ross CL, 2009, INTEGR MED INSIGHTS, V4, P13
   Ryan JL, 2012, SUPPORT CARE CANCER, V20, P1479, DOI 10.1007/s00520-011-1236-3
   Shin HC, 2016, LARYNGOSCOPE, V126, P1761, DOI 10.1002/lary.25883
   Soden K, 2004, PALLIATIVE MED, V18, P87, DOI 10.1191/0269216304pm874oa
   Soltani R, 2013, INT J PEDIATR OTORHI, V77, P1579, DOI 10.1016/j.ijporl.2013.07.014
   Tabatabaee Amir, 2016, Med Arch, V70, P142, DOI [10.5455/medarh.2016.70.142-147, 10.5455/medarh.2016.70.142-147]
   Thapar A, 2012, LANCET, V379, P1056, DOI 10.1016/S0140-6736(11)60871-4
   Tilbrook HE, 2011, ANN INTERN MED, V155, P569, DOI 10.7326/0003-4819-155-9-201111010-00003
   WEN HL, 1977, MOD MED ASIA, V13, P12
   Willison Kevin D., 2005, Journal of Cancer Integrative Medicine, V3, P71, DOI DOI 10.2310/7200.2005.32004
NR 69
TC 7
Z9 9
U1 1
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD JUN
PY 2018
VL 5
IS 6
AR 75
DI 10.3390/children5060075
PG 12
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA GK6DQ
UT WOS:000436273300012
PM 29899281
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Huemer, M
   Graca, S
   Bitsche, S
   Hofmann, G
   Armour, M
   Pichler, M
AF Huemer, Matthias
   Graca, Sandro
   Bitsche, Sarah
   Hofmann, Guenter
   Armour, Mike
   Pichler, Martin
TI Mapping the clinical practice of traditional, complementary and
   integrative medicine in oncology in Western countries: A multinational
   cross-sectional survey
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Article
DE Integrative medicine; Acupuncture; Oncology; Evidence -informed
   practice; International survey
ID ALTERNATIVE MEDICINE; CANCER-PATIENTS; UNITED-STATES; ACUPUNCTURE;
   MANAGEMENT; THERAPIES; SURVIVORS; SOCIETY
AB Background: Many cancer patients seek adjunctive therapies to biomedical cancer treatments at some point of their disease trajectory. While acupuncture is increasingly recommended by leading oncological associations, limited evidence exists concerning the evidence-informed practice and adherence to current guidelines of traditional complementary and integrative medicine (TCIM) practitioners treating cancer patients. Methods: An international online-survey assessed the demographical data, clinical practice, and sources of information used by TCIM practitioners in Austria, Germany, United States of America, Australia, and New Zealand. Results: In total, 404 respondents completed the survey, of which 254 (62.9%) treated cancer patients. Most practitioners were acupuncturists and herbalists (57.1%), had (16.8 +/- 9.9) years of clinical experience and see a median of 2 (1, 4) cancer patients per week. Breast cancer (61.8%) is the most common cancer type seen in TCIM clinics. Adjunctive TCIM treatments are frequently concurrent with the patient's cancer specific treatment (39.9%), which is also reflected by the main goal of a TCIM treatment to alleviate side effects (52.4%). However, only 28.0% of the respondents are in contact with the treating oncologist. According to the respondents, pain is most effectively treated using acupuncture, while herbal medicine is best for cancer-related fatigue. TCIM practitioners mostly use certified courses (33.1%) or online databases (28.3%) but often believe that experts are more reliable to inform their practice (37.0%) than research publications (32.7%). Conclusion: Acupuncturists and herbalists commonly treat cancer patients. Most practitioners use TCIM as an adjunct to biomedicine as supportive care and use it largely in accordance with current oncological guidelines. Please cite this article as: Huemer M, Graca S, Bitsche S, Hofmann G, Armour M, Pichler M. Mapping the clinical practice of traditional, complementary and integrative medicine in oncology in Western countries: A multinational cross-sectional survey. J Integr Med. 2024; 22(1): 64-71. (c) 2023 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Huemer, Matthias; Bitsche, Sarah; Hofmann, Guenter; Pichler, Martin] Med Univ Graz, Dept Internal Med, Div Oncol, Palliat Care Unit, A-8036 Graz, Austria.
   [Graca, Sandro] Northern Coll Acupuncture, York YO1 6LJ, England.
   [Graca, Sandro] Univ Wolverhampton, Fac Educ Hlth & Wellbeing, Sch Hlth & Soc, Wolverhampton WV1 1LY, England.
   [Armour, Mike] Western Sydney Univ, Natl Inst Complementary Med Hlth Res Inst, Penrith, NSW 2751, Australia.
   [Armour, Mike] Western Sydney Univ, Translat Hlth Res Inst, Penrith, NSW 2751, Australia.
   [Armour, Mike] Med Res Inst New Zealand, Wellington 6021, New Zealand.
   [Pichler, Martin] Univ Hosp Augsburg, Translat Oncol, D-86156 Augsburg, Germany.
C3 Medical University of Graz; University of Wolverhampton; Western Sydney
   University; Western Sydney University; Medical Research Institute Of New
   Zealand
RP Huemer, M (corresponding author), Med Univ Graz, Dept Internal Med, Div Oncol, Palliat Care Unit, A-8036 Graz, Austria.
EM matthias.huemer@medunigraz.at
RI Graca, Sano/AGN-6704-2022; Armour, Mike/I-4853-2016
OI Graca, Sano/0000-0002-3538-4038; 
CR Anderson JG, 2012, J ALTERN COMPLEM MED, V18, P235, DOI 10.1089/acm.2011.0022
   [Anonymous], 2023, Cancer-Related Fatigue (Version 2.2023)
   [Anonymous], WHO global report on traditional and complementary medicine 2019
   [Anonymous], 2023, Traditional, Complementary and Integrative Medicine
   Armour M, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18020834
   Bower JE, 2014, J CLIN ONCOL, V32, P1840, DOI 10.1200/JCO.2013.53.4495
   Chung VCH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002793
   Dai ZQ, 2022, PHYTOMEDICINE, V98, DOI 10.1016/j.phymed.2021.153921
   Das Rechtsinformationssystem des Bundes, 2023, Austrian laws
   Fan AY, 2018, COMPLEMENT THER MED, V41, P295, DOI 10.1016/j.ctim.2018.10.015
   Graca S, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03576-3
   Guo J, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420959442
   Harris PA, 2019, J BIOMED INFORM, V95, DOI 10.1016/j.jbi.2019.103208
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Ijaz N, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226601
   Keene MR, 2019, COMPLEMENT THER CLIN, V35, P33, DOI 10.1016/j.ctcp.2019.01.004
   Lin K, 2017, MED ACUPUNCT, V29, P121, DOI 10.1089/acu.2017.1235
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   Miller David W, 2021, Glob Adv Health Med, V10, p21649561211042574, DOI [10.1177/21649561211042574, 10.1177/21649561211042574]
   Molassiotis A, 2005, ANN ONCOL, V16, P655, DOI 10.1093/annonc/mdi110
   National Comprehensive Cancer Network, 2023, Antiemesis (version 1.2024)
   National Comprehensive Cancer Network, 2022, Adult Cancer Pain (Version 2.2022)
   Rossi E, 2015, SUPPORT CARE CANCER, V23, P1795, DOI 10.1007/s00520-014-2517-4
   Stratton SJ, 2021, PREHOSP DISASTER MED, V36, P373, DOI 10.1017/S1049023X21000649
   Svenkerud S, 2018, ACUPUNCT MED, V36, P349, DOI 10.1136/acupmed-2017-011519
   Truant Tracy L, 2013, J Support Oncol, V11, P105
   Verhoef MJ, 2007, INTEGR CANCER THER, V6, P345, DOI 10.1177/1534735407309482
   Wang HY, 2018, AM J CHINESE MED, V46, P1387, DOI 10.1142/S0192415X18500738
   Weeks Laura, 2014, Open Med, V8, pe54
   Zhang C, 2022, J ETHNOPHARMACOL, V285, DOI 10.1016/j.jep.2021.114892
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 34
TC 7
Z9 7
U1 4
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD JAN
PY 2024
VL 22
IS 1
BP 64
EP 71
DI 10.1016/j.joim.2023.12.002
EA MAR 2024
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA OF6I4
UT WOS:001205886800001
PM 38199884
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Bauer, BA
   Tilburt, JC
   Sood, A
   Li, GX
   Wang, SH
AF Bauer, Brent A.
   Tilburt, Jon C.
   Sood, Amit
   Li Guang-xi
   Wang Shi-han
TI Complementary and alternative medicine therapies for chronic pain
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE complementary and alternative medicine; therapy; chronic pain; safety
   and effificacy
ID LOW-BACK-PAIN; MASSAGE THERAPY; HERBAL MEDICINES; SELF-MANAGEMENT;
   ACUPUNCTURE; PLACEBO; METAANALYSIS; EFFICACY; CANCER; BIOFEEDBACK
AB Pain afflflicts over 50 million people in the US, with 30.7% US adults suffering with chronic pain. Despite advances in therapies, many patients will continue to deal with ongoing symptoms that are not fully addressed by the best conventional medicine has to offer them. The patients frequently turn to therapies outside the usual purview of conventional medicine (herbs, acupuncture, meditation, etc.) called complementary and alternative medicine (CAM). Academic and governmental groups are also starting to incorporate CAM recommendations into chronic pain management strategies. Thus, for any physician who care for patients with chronic pain, having some familiarity with these therapies-including risks and benefits-will be key to helping guide patients in making evidence-based, well informed decisions about whether or not to use such therapies. On the other hand, if a CAM therapy has evidence of both safety and efficacy then not making it available to a patient who is suffering does not meet the need of the patient. We summarize the current evidence of a wide variety of CAM modalities that have potential for helping patients with chronic pain in this article. The triad of chronic pain symptoms, ready access to information on the internet, and growing patient empowerment suggest that CAM therapies will remain a consistent part of the healthcare of patients dealing with chronic pain.
C1 [Bauer, Brent A.; Tilburt, Jon C.; Sood, Amit] Mayo Clin, Div Complementary & Integrat Med, Rochester, MN 55905 USA.
   [Li Guang-xi] Mayo Clin, Div Pulm & Crit Care Med, Rochester, MN 55905 USA.
   [Li Guang-xi; Wang Shi-han] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing 100053, Peoples R China.
   [Wang Shi-han] Mayo Clin, Div Cardiovasc Dis, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; China Academy of Chinese Medical Sciences;
   Guang'anmen Hospital, CACMS; Mayo Clinic
RP Bauer, BA (corresponding author), Mayo Clin, Div Complementary & Integrat Med, Rochester, MN 55905 USA.
EM Bauer.brent@mayo.edu
RI Li, Guangxi/AAB-3946-2019
OI Li, Guangxi/0000-0002-2234-9188
FU Thorne Research
FX Drs. Sood A, Tilburt JC, Li GX and Wang SH declare that they have no
   conflicts of interest. Dr. Bauer has received research support from
   Thorne Research.
CR Abdualmjid RJ, 2013, J PHARM PHARM SCI, V16, P376, DOI 10.18433/J36G6X
   [Anonymous], EVID BASED COMPLEMEN
   [Anonymous], 2014, COCHRANE DATABASE SY
   Baeumler PI, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113731
   Bai Y, 2014, J TRADIT CHIN MED, V34, P381, DOI 10.1016/S0254-6272(15)30037-6
   Bao YJ, 2014, SUPPORT CARE CANCER, V22, P825, DOI 10.1007/s00520-013-2063-5
   Bawa FLM, 2015, BRIT J GEN PRACT, V65, pE387, DOI 10.3399/bjgp15X685297
   Bottiglieri T, 2002, AM J CLIN NUTR, V76, p1151S, DOI 10.1093/ajcn/76.5.1151S
   BOWSHER D, 1988, PAIN MANAGEMENT CONT, pCH13
   Brosseau L, 2012, J BODYW MOV THER, V16, P424, DOI 10.1016/j.jbmt.2012.04.002
   Brown CA, 2010, PAIN, V150, P428, DOI 10.1016/j.pain.2010.04.017
   Cameron M, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002947.pub2
   Cameron M, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010538
   Chaibi A, 2014, J HEADACHE PAIN, V15, DOI 10.1186/1129-2377-15-67
   Chandran B, 2012, PHYTOTHER RES, V26, P1719, DOI 10.1002/ptr.4639
   Chantre P, 2000, PHYTOMEDICINE, V7, P177, DOI 10.1016/S0944-7113(00)80001-X
   CHEN S, 2014, EVID-BASED COMPL ALT, V2014, DOI DOI 10.1155/2014/609594
   Chen W, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007796.pub3
   Cheng YH, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/204360
   Chenot Jean-Francois, 2007, BMC Complement Altern Med, V7, P42, DOI 10.1186/1472-6882-7-42
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   Cramer H, 2013, CLIN J PAIN, V29, P450, DOI 10.1097/AJP.0b013e31825e1492
   Dickinson A, 2014, J AM COLL NUTR, V33, P176, DOI 10.1080/07315724.2013.875423
   Federal Register, 2007, CURR GOOD MAN PRAC S
   Fox KCR, 2014, NEUROSCI BIOBEHAV R, V43, P48, DOI 10.1016/j.neubiorev.2014.03.016
   GOATS GC, 1994, BRIT J SPORT MED, V28, P153, DOI 10.1136/bjsm.28.3.153
   Habermann TM, 2009, AM J HEMATOL, V84, P795, DOI 10.1002/ajh.21554
   Hall KT, 2015, TRENDS MOL MED, V21, P285, DOI 10.1016/j.molmed.2015.02.009
   Harris RE, 2009, NEUROIMAGE, V47, P1077, DOI 10.1016/j.neuroimage.2009.05.083
   Hassett AL, 2011, PSYCHIAT CLIN N AM, V34, P579, DOI 10.1016/j.psc.2011.05.004
   Hatayama T, 2008, BIOMED RES-TOKYO, V29, P317, DOI 10.2220/biomedres.29.317
   Holtzman S, 2013, PAIN RES MANAG, V18, P267, DOI 10.1155/2013/105919
   Izzo AA, 2009, DRUGS, V69, P1777, DOI 10.2165/11317010-000000000-00000
   Johannes CB, 2010, J PAIN, V11, P1230, DOI 10.1016/j.jpain.2010.07.002
   Johnson AC, 2014, J PHARMACOL EXP THER, V351, P327, DOI 10.1124/jpet.114.218065
   Kapitza KP, 2010, APPL PSYCHOPHYS BIOF, V35, P207, DOI 10.1007/s10484-010-9130-1
   Kaptchuk TJ, 2015, NEW ENGL J MED, V373, P8, DOI 10.1056/NEJMp1504023
   Keeratitanont K, 2015, COMPLEMENT THER CLIN, V21, P26, DOI 10.1016/j.ctcp.2015.01.006
   Kim KH, 2013, COMPLEMENT THER MED, V21, P535, DOI 10.1016/j.ctim.2013.08.007
   Kirkpatrick DR, 2015, CTS-CLIN TRANSL SCI, V8, P848, DOI 10.1111/cts.12282
   Ko RJ, 1998, NEW ENGL J MED, V339, P847, DOI 10.1056/NEJM199809173391214
   Kong LJ, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/613279
   Kumar S, 2013, INT J GEN MED, V6, P733, DOI 10.2147/IJGM.S50243
   Lai MY, 2006, NEPHROL DIAL TRANSPL, V21, P233, DOI 10.1093/ndt/gfi158
   Lee C, 2014, PAIN MED, V15, pS40, DOI 10.1111/pme.12411
   Lee C, 2014, PAIN MED, V15, pS21, DOI 10.1111/pme.12383
   Lee JW, 2015, COMPLEMENT THER MED, V23, P265, DOI 10.1016/j.ctim.2015.02.003
   Lee SH, 2015, INTEGR CANCER THER, V14, P297, DOI 10.1177/1534735415572885
   Lee WT, 2015, FOOD CHEM TOXICOL
   Li YH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089304
   Linde K, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001218.pub2
   Liu LZ, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/328196
   Madsen MV, 2009, BMJ-BRIT MED J, V338, DOI 10.1136/bmj.a3115
   Manyanga T, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-312
   Martin DP, 2006, MAYO CLIN PROC, V81, P749, DOI 10.4065/81.6.749
   Mayoclinic.org, 2015, ACUPUNCTURE
   Mayoclinic.org, 2013, MASS GET TOUCH ITS M
   Milic N, 2014, NAT PROD COMMUN, V9, P1211
   Moon TW, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/870271
   Nakata H, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.01489
   Netchanok Sritoomma, 2012, Complement Ther Clin Pract, V18, P227, DOI 10.1016/j.ctcp.2012.07.001
   Nolano M, 1999, PAIN, V81, P135, DOI 10.1016/S0304-3959(99)00007-X
   Radley JJ, 2013, J NEUROSCI, V33, P14379, DOI 10.1523/JNEUROSCI.0287-13.2013
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Rausch SM, 2011, SUPPORT CARE CANCER, V19, P521, DOI 10.1007/s00520-010-0846-5
   Ruschitzka F, 2000, LANCET, V355, P548, DOI 10.1016/S0140-6736(99)05467-7
   Russo E, 2014, PHYTOTHER RES, V28, P643, DOI 10.1002/ptr.5050
   Scharf ML, 2015, J BRONCHOL INTERN PU, V22, P162, DOI 10.1097/LBR.0000000000000149
   Scharff L, 2002, J PEDIATR PSYCHOL, V27, P109, DOI 10.1093/jpepsy/27.2.109
   Schmid J, 2013, PAIN, V154, P2372, DOI 10.1016/j.pain.2013.07.013
   Schwarz UI, 2003, BRIT J CLIN PHARMACO, V55, P112, DOI 10.1046/j.1365-2125.2003.01716.x
   Somani S, 2013, J PAK MED ASSOC, V63, P1418
   Spinella M, 2001, EPILEPSY BEHAV, V2, P524, DOI 10.1006/ebeh.2001.0281
   Su J W, 2007, Singapore Med J, V48, pe32
   U.S. Department of Veterans Affairs, 2015, PROACT PAIN MAN 10 W
   *US DEP HHS, 2007, SUMM HLTH STAT US AD
   van den Dolder PA, 2014, BRIT J SPORT MED, V48, P1216, DOI 10.1136/bjsports-2011-090553
   Vanherweghem J L, 1994, Bull Mem Acad R Med Belg, V149, P128
   Wahner-Roedler DL, 2005, MAYO CLIN PROC, V80, P55
   Wan DWL, 2015, EUR J PAIN, V19, P1232, DOI 10.1002/ejp.671
   Wheway Jayne, 2012, Int J Risk Saf Med, V24, P163, DOI 10.3233/JRS-2012-0569
   Yeh CH, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/934670
   Yin P, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/480956
   Yuan M, 2009, TRANSPL P, V41, P1619, DOI 10.1016/j.transproceed.2009.01.081
   Yuan QL, 2015, PLOS ONE, V10, DOI [10.1371/journal.pone.0117146, 10.1371/journal.pone.0119403]
   Yuan SLK, 2015, MANUAL THER, V20, P257, DOI 10.1016/j.math.2014.09.003
   Zeidan F, 2012, NEUROSCI LETT, V520, P165, DOI 10.1016/j.neulet.2012.03.082
   Zhao HJ, 2015, COMPLEMENT THER CLIN, V21, P68, DOI 10.1016/j.ctcp.2015.03.006
NR 89
TC 54
Z9 64
U1 0
U2 30
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD JUN
PY 2016
VL 22
IS 6
BP 403
EP 411
DI 10.1007/s11655-016-2258-y
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DQ2DH
UT WOS:000379011200001
PM 27339090
DA 2026-01-16
ER

PT J
AU Su, XJ
   Song, PF
   Meng, FC
   Xu, WS
   Xing, H
   Zhang, H
AF Su, Xiaojie
   Song, Pengfei
   Meng, Fanchao
   Xu, Wenshuai
   Xing, Hua
   Zhang, Hong
TI Tuina Manipulation to Reduce Inflammation and Cartilage Loss in Knee
   Osteoarthritis Rats
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID MASSAGE
AB Clinical trials suggest that Tuina manipulation is effective in treating knee osteoarthritis (KOA), while further studies are required to discover its mechanism. Therefore, the manipulation of animal models of knee osteoarthritis is critical. This protocol provides a standard process for Tuina manipulation on KOA rats and a preliminary exploration of the mechanism of Tuina for KOA. The press and kneading manipulation method (a kind of Tuina manipulation that refers to pressing and kneading the specific area of the body surface) is applied on 5 acupoints around the knee joint of rats. The force and frequency of the manipulation were standardized by finger pressure recordings, and the position of the rat during manipulation is described in detail in the protocol. The effect of manipulation can be measured by pain behavior tests and microscopic findings in synovial and cartilage. KOA rats showed significant improvement in pain behavior. The synovial tissue inflammatory infiltration was reduced in the Tuina group, and the expression of tumor necrosis factor (TNF)-alpha was significantly lower. Compared to the control group, chondrocyte apoptosis was less in the Tuina group. This study provides a standardized protocol for Tuina manipulation on KOA rats and preliminary proof that the therapeutic effects of Tuina may be related to reducing synovial inflammation and delayed chondrocyte apoptosis.
C1 [Su, Xiaojie; Song, Pengfei; Meng, Fanchao; Xu, Wenshuai; Xing, Hua; Zhang, Hong] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Xing, H; Zhang, H (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Shanghai, Peoples R China.
EM yyyyxinghua@shutcm.edu.cn; zhanghongdoctor@sina.com
FU Shanghai Critical Clinical Specialties Construction Project
   [Shslczdzk04001]; Sailing program of Shanghai Science and Technology
   Commission [22YF1444300]; Projects within the budget of Shanghai
   University of Traditional Chinese Medicine [2021LK091]
FX This work was supported by Shanghai Critical Clinical Specialties
   Construction Project (Grant Number: Shslczdzk04001); the Sailing program
   of Shanghai Science and Technology Commission (Grant Number:
   22YF1444300); Projects within the budget of Shanghai University of
   Traditional Chinese Medicine (Grant Number: 2021LK091).
CR Callahan LF, 2021, RHEUM DIS CLIN N AM, V47, P1, DOI 10.1016/j.rdc.2020.09.001
   Chen C., 2018, Hainan Medical Journal, V29, P2617
   Ding X., 2021, Shanghai Journal of Traditional Chinese Medicine, V55, P54
   Fan C, 2020, INT J DAMAGE MECH, V29, P887, DOI 10.1177/1056789519890064
   Fu Y., 2020, Jilin Journal of Chinese Medicine, V40, P958
   Gong L., 2016, Chin J Orthopaed Traumatol Tradition Chin Med, V24, P16
   [古来撒尔·艾克拜尔 Gulaisaer Aikebaier], 2022, [中国中医药信息杂志, Chinese Journal of Information on Traditional Chinese Medicine], V29, P23
   Guo Y., 2011, Chinese Acupuncture & Moxibustion, V31, P549
   He Y, 2020, Chinese Imaging Journal of Integrated Traditional and Western Medicine, V18, P198
   Hua X, 2021, J ACUPUNCT TUINA SCI, V19, P354, DOI 10.1007/s11726-021-1266-4
   HULTH A, 1970, ACTA ORTHOP SCAND, V41, P522, DOI 10.3109/17453677008991540
   Jeong J, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2149-1
   Jiang J., 2018, Journal of Changchun University of Chinese Medicine, V34, P129
   Joint Surgery Group Orthopaedic Branch, 2021, Chin J Orthop, V41, P24
   Li C., 2020, Journal of Guangzhou University of Traditional Chinese Medicine, V37, P2157
   [梁玉磊 Liang Yulei], 2014, [时珍国医国药, Lishizhen Medicine and Materia Medica Research], V25, P2299
   Liu J, 2019, Effect of Massage on TLR4/MyD88 Signal Transduction Pathway in Rat Knee Osteoarthritis Model
   [刘晶 Liu Jing], 2020, [康复学报, Rehabilitation Medicine], V30, P212, DOI 10.3724/sp.j.1329.2020.03009
   Luo R, 2017, The effects of IL-1B,IL-6,IL-13,IL-26,TNF-a by patellar manipulations on rabbit knee osteoarthritis model
   Moskowitz RW, 2006, OSTEOARTHR CARTILAGE, V14, P1, DOI 10.1016/j.joca.2005.08.015
   Perlman A, 2019, J GEN INTERN MED, V34, P379, DOI 10.1007/s11606-018-4763-5
   Qian J., 2014, Research and Exploration in Laboratory, V33, P23
   Qiu F., 2021, Acta Chinese Medicine, V36, P649
   Seo BR, 2021, SCI TRANSL MED, V13, DOI 10.1126/scitranslmed.abe8868
   Shang P., 2006, Orthopaedic Biomechanics Materials and Clinical Study, P11
   Shen M., 2009, Chinese Medicine Modern Distance Education of China, V7, P130
   Song PF, 2018, J TRADIT CHIN MED, V38, P834
   Spitaels D, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-031734
   Tan Q., 2022, Chin. J. Tissue Eng. Res, V26, P1714
   Tawonsawatruk T, 2018, BONE JOINT RES, V7, P244, DOI 10.1302/2046-3758.73.BJR-2017-0121.R2
   Wang K., 2017, National Medical Journal of China, V97, P4
   Wu J. H., 2018, Chinese General Practice, V21, P688
   Yan XH., 2017, ACTA CHIN ME, V32, P875
   Yang B., 2022, Acta Chinese Medicine, V37, P2571
   Yu S., 2022, Journal of Guangxi University of Chinese Medicine, V25, P50
   Zeng J., 2016, Chinese Journal of Clinical Research, V29, P679
   Zhang Z, 2019, Henan Traditional Chinese Medicine, V39, P146
   Zhou Q, 2015, BMC MUSCULOSKEL DIS, V16, DOI 10.1186/s12891-015-0679-y
NR 38
TC 0
Z9 0
U1 2
U2 23
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD JUN
PY 2023
IS 196
AR e65451
DI 10.3791/65451
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA R8FG9
UT WOS:001066654000042
PM 37458470
DA 2026-01-16
ER

PT J
AU Armstrong, K
   Lanni, T 
   Anderson, MM
   Patricolo, GE
AF Armstrong, Karen
   Lanni, Thomas, Jr.
   Anderson, Maureen M.
   Patricolo, Gail Elliott
TI Integrative medicine and the oncology patient: options and benefits
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Integrative medicine; Cancer; Oncology patients; Oncology massage;
   Acupuncture; Naturopathic oncology
ID RADIATION-INDUCED XEROSTOMIA; BREAST-CANCER SURVIVORS; GUIDED IMAGERY;
   YOGA PROGRAM; ACUPUNCTURE; MASSAGE; COMPLEMENTARY; INTERVENTIONS;
   PREVENTION; MANAGEMENT
AB Cancer is a major public health problem, and cancer patients and survivors face many physical and emotional challenges after the initial diagnosis, through treatment, and in the post-treatment period. Different integrative medicine (IM) modalities can be used to mitigate some of the physical issues that originate from the cancer itself or the treatment and to promote well-being and emotional health. Here, we discuss how an IM Department can function in a hospital system, particularly with regard to oncology patients, the modalities appropriate for oncology patients, how these modalities can benefit this patient population, and the role of IM in cancer survivorship. A dedicated IM Department that works with oncologists provides support and care for the whole person. These different modalities work together to reduce pain, anxiety, and chemotherapy-induced nausea and peripheral neuropathy, while promoting immune function and improving sleep, range of motion, and an overall sense of well-being. However, each modality has different contraindications for the oncology patient, and proper training is required for safe and effective care. We illustrate how IM can be a valuable component of the care of the oncology patient.
C1 [Armstrong, Karen; Anderson, Maureen M.; Patricolo, Gail Elliott] Beaumont Hlth, Integrat Med, 3577 W Thirteen Mile Rd, Royal Oak, MI 48073 USA.
   [Lanni, Thomas, Jr.] Beaumont Hlth, Beaumont Canc Inst, Oncol Med & Imaging, Royal Oak, MI 48073 USA.
C3 Beaumont Health; Beaumont Health
RP Patricolo, GE (corresponding author), Beaumont Hlth, Integrat Med, 3577 W Thirteen Mile Rd, Royal Oak, MI 48073 USA.
EM gail.elliottpatricolo@beaumont.org
CR [Anonymous], J HOSP ADM
   [Anonymous], J HOSP ADM
   [Anonymous], 2017, COMPLEMENTARY ALTERN
   [Anonymous], TRAD CHIN MED DEPTH
   [Anonymous], TAK TIM SUPP PEOPL C
   [Anonymous], MASSAGE THER J
   Arthur Kristen, 2013, Cancer Clin Oncol, V2, P81
   Barnes PM., 2008, NATL HLTH STAT REPOR, DOI DOI 10.1037/E623942009-001
   Billhult A, 2009, AUTON NEUROSCI-BASIC, V150, P111, DOI 10.1016/j.autneu.2009.03.010
   Buffart LM, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-559
   Carlson LE, 2008, CURR TREAT OPTION ON, V9, P127, DOI 10.1007/s11864-008-0064-2
   Carrico DJ, 2008, J ALTERN COMPLEM MED, V14, P53, DOI 10.1089/acm.2007.7070
   Chaoul A, 2014, CURR ONCOL REP, V16, DOI 10.1007/s11912-014-0417-x
   Collinge William, 2012, Semin Oncol Nurs, V28, P45, DOI 10.1016/j.soncn.2011.11.005
   Cramer H, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-412
   Cunningham JE, 2011, SUPPORT CARE CANCER, V19, P1473, DOI 10.1007/s00520-011-1231-8
   Demir M, 2013, ASIAN PAC J CANCER P, V14, P4931, DOI 10.7314/APJCP.2013.14.8.4931
   Derry HM, 2015, PSYCHO-ONCOLOGY, V24, P958, DOI 10.1002/pon.3707
   Braga FDF, 2011, BRAZ ORAL RES, V25, P180
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Gusani NJ, 2009, J GEN INTERN MED, V24, P456, DOI 10.1007/s11606-009-1010-0
   Hu CQ, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1720239
   Lanni T, 2016, ALTERN COMPLEMENT TH, V22, P153, DOI [10.1089/act.2016.29064.tla, DOI 10.1089/act.2016.29064.tla]
   Lu WD, 2013, CURR PAIN HEADACHE R, V17, DOI 10.1007/s11916-013-0321-3
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   Matourypour Pegah, 2016, Iran J Nurs Midwifery Res, V21, P255, DOI [10.4103/1735-9066.180373, 10.4103/1735-9066.180373]
   Meng ZQ, 2012, CANCER-AM CANCER SOC, V118, P3337, DOI 10.1002/cncr.26550
   Milbury K, 2015, PSYCHO-ONCOLOGY, V24, P117, DOI 10.1002/pon.3588
   Patricolo GE, 2017, CRIT CARE NURSE, V37, P62, DOI 10.4037/ccn2017282
   Patricolo GE, 2015, BREAST, V24, P82, DOI 10.1016/j.breast.2014.10.004
   Peppone LJ, 2015, BREAST CANCER RES TR, V150, P597, DOI 10.1007/s10549-015-3351-1
   Post-White Janice, 2003, Integr Cancer Ther, V2, P332, DOI 10.1177/1534735403259064
   Rao RM, 2015, INDIAN J PALLIAT CAR, V21, P174, DOI 10.4103/0973-1075.156486
   Richardson MA, 2000, J CLIN ONCOL, V18, P2505, DOI 10.1200/JCO.2000.18.13.2505
   Running A, 2012, CURR PAIN HEADACHE R, V16, P325, DOI 10.1007/s11916-012-0275-x
   Sadja J, 2013, EXPLORE-NY, V9, P232, DOI 10.1016/j.explore.2013.04.005
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Shin TM, 2012, DERMATOL SURG, V38, P414, DOI 10.1111/j.1524-4725.2011.02201.x
   Siegel RL, 2016, CA-CANCER J CLIN, V66, P7, DOI 10.3322/caac.21332
   Sprod LK, 2015, J GERIATR ONCOL, V6, P8, DOI 10.1016/j.jgo.2014.09.184
   Thrane S, 2014, PAIN MANAG NURS, V15, P897, DOI 10.1016/j.pmn.2013.07.008
   Wilk I, 2015, REHABIL NURS, V40, P294, DOI 10.1002/rnj.142
   Wood D., 2013, ALTERN COMPLEMENT TH, V19, P301, DOI [DOI 10.1089/act.2013.19604, 10.1089/act.2013.19604]
   Wyatt G, 2012, ONCOL NURS FORUM, V39, P568, DOI 10.1188/12.ONF.568-577
   Zhuang LP, 2013, INTEGR CANCER THER, V12, P197, DOI 10.1177/1534735412451321
NR 45
TC 22
Z9 24
U1 1
U2 23
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JUL
PY 2018
VL 26
IS 7
BP 2267
EP 2273
DI 10.1007/s00520-017-4007-y
PG 7
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA GH9AL
UT WOS:000433961300022
PM 29396594
DA 2026-01-16
ER

PT J
AU Mongardi, L
   Visani, J
   Mantovani, G
   Vitali, C
   Ricciardi, L
   Giordano, F
   Cavallo, MA
   Lofrese, G
   D'andrea, M
   Roblot, P
   De Bonis, P
   Scerrati, A
AF Mongardi, Lorenzo
   Visani, Jacopo
   Mantovani, Giorgio
   Vitali, Costanza
   Ricciardi, Luca
   Giordano, Flavio
   Cavallo, Michele Alessandro
   Lofrese, Giorgio
   D'andrea, Marcello
   Roblot, Paul
   De Bonis, Pasquale
   Scerrati, Alba
TI Long term results of Dorsal Root Entry Zone (DREZ) lesions for the
   treatment of intractable pain: A systematic review of the literature on
   1242 cases
SO CLINICAL NEUROLOGY AND NEUROSURGERY
LA English
DT Review
DE Root entry zone; DREZ; DREZotomy; Chronic pain; Intractable pain
ID BRACHIAL-PLEXUS AVULSION; PHANTOM LIMB PAIN; MICROSURGICAL DREZOTOMY;
   DEAFFERENTATION PAIN; NEUROPATHIC PAIN; FOLLOW-UP; CENTRAL
   SENSITIZATION; CONUS MEDULLARIS; HORN; EXPERIENCE
AB Background: Different Dorsal root entry zone (DREZ) lesion techniques have been reported as effective treatment for intractable painful conditions, though with contradictory results. Overall, good results were reported especially in specific conditions, such as pain due to brachial plexus avulsion, spinal cord injuries and oncological pain management. However, data on long term results in different clinical conditions are still missing. Objective: This study aims to systematically review the pertinent literature to evaluate indications, clinical outcomes, and complications of DREZ lesion (DREZotomy), in chronic pain management. Methods: A systematic literature review was conducted according to the PRISMA statement. Papers on DREZotomy for chronic pain in cancer, brachial plexus avulsion, spinal cord injury, post herpetic neuralgia, and phantom limb pain were considered for eligibility. For each category we further identified two sub-group according to the length of follow up: medium term and long term follow up (more than 3 years) respectively. Results: 46 papers, and 1242 patients, were included in the present investigation. When considering long term results DREZotomy provided favorable clinical outcomes in brachial plexus avulsion and spinal cord injury, in 60.8% and 55.8% of the cases respectively. Conversely, the success rate was 35.3% in phantom limb pain and 28.2% in post herpetic neuralgia. A poor clinical outcome was reported in over than 25% of the patients suffering from phantom limb pain, post herpetic neuralgia and spinal cord injury. The mean complications rate was 23.58%. While BPA and SCI patients presented stable improvement over time, good outcomes among PHN and PLP groups dropped by - 46.2%; and - 14.7% at long term follow up respectively. Conclusion: DREZotomy seems to be an effective treatment for chronic pain conditions, especially for brachial plexus avulsion, spinal cord injury and intractable cancer/post-radiation pain. According to the low level of evidence of the pertinent literature, further studies are strongly recommended, to better define potential benefits and limitations of this technique
C1 [Mongardi, Lorenzo; Visani, Jacopo; Mantovani, Giorgio; Cavallo, Michele Alessandro; De Bonis, Pasquale; Scerrati, Alba] St Anna Univ Hosp, Dept Neurosurg, Ferrara, Italy.
   [Vitali, Costanza] Univ Ferrara, Sect Anaesthesia & Intens Care, Azienda Osped Univ St Anna, Dept Morphol Surg & Expt Med, Ferrara, Italy.
   [Ricciardi, Luca] Pia Fdn Culto & Relig Cardinal G Panico, UO Neurochirurg, Tricase, LE, Italy.
   [Giordano, Flavio] Univ Florence, Childrens Hosp A Meyer, Dept Neurosurg, Florence, Italy.
   [Cavallo, Michele Alessandro; De Bonis, Pasquale; Scerrati, Alba] Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Italy.
   [Lofrese, Giorgio; D'andrea, Marcello] Bufalini Hosp, Neurosurg, Cesena, Italy.
   [Roblot, Paul] Univ Hosp Bordeaux, Dept Neurosurg, Bordeaux, France.
C3 University of Ferrara; Arcispedale Sant'Anna; University of Ferrara;
   Arcispedale Sant'Anna; University of Florence; Azienda Ospedaliera
   Universitaria (AOU) MEYER; University of Ferrara; Universite de
   Bordeaux; CHU Bordeaux
RP Mongardi, L (corresponding author), St Anna Univ Hosp, Dept Neurosurg, Ferrara, Italy.
EM lorenzo.mongardi@student.unife.it
RI mongardi, lorenzo/AAI-2247-2020; Scerrati, Alba/Z-2079-2019; Lofrese,
   Giorgio/AAH-6862-2021; Mantovani, Giorgio/GNH-4247-2022; Visani,
   Jacopo/ABF-9970-2021; de bonis, pasquale/LGY-7253-2024; GIORDANO,
   FLAVIO/K-4961-2016; Ricciardi, Luca/L-5405-2019
OI Mantovani, Giorgio/0000-0002-2164-2710; GIORDANO,
   FLAVIO/0000-0002-9006-9225; D'Anea, Marcello/0000-0003-0894-7509;
   Ricciardi, Luca/0000-0001-5110-8386
CR Aichaoui F, 2011, PAIN, V152, P1923, DOI 10.1016/j.pain.2011.03.037
   Awad Ahmed J, 2013, Surg Neurol Int, V4, P64, DOI 10.4103/2152-7806.112182
   Bernard E J Jr, 1987, Br J Neurosurg, V1, P81, DOI 10.3109/02688698709034343
   Bouhassira D, 2004, PAIN, V108, P248, DOI 10.1016/j.pain.2003.12.024
   BRUXELLE J, 1988, CLIN ORTHOP RELAT R, P87
   Bullard DE, 1997, STEREOT FUNCT NEUROS, V68, P168, DOI 10.1159/000099918
   CAMPBELL JN, 1988, APPL NEUROPHYSIOL, V51, P170
   Chen HJ, 2006, ACTA NEUROCHIR SUPPL, V99, P73, DOI 10.1007/978-3-211-35205-2_14
   Chivukula S, 2015, WORLD NEUROSURG, V84, P494, DOI 10.1016/j.wneu.2015.04.025
   Chun HJ, 2011, WORLD NEUROSURG, V75, P551, DOI 10.1016/j.wneu.2010.12.005
   DREVAL ON, 1993, ACTA NEUROCHIR, V122, P76, DOI 10.1007/BF01446990
   Emery E, 1997, STEREOT FUNCT NEUROS, V68, P155, DOI 10.1159/000099916
   Esposito S, 1988, J Neurosurg Sci, V32, P113
   FRIEDMAN AH, 1984, J NEUROSURG, V60, P1258, DOI 10.3171/jns.1984.60.6.1258
   FRIEDMAN AH, 1988, NEUROSURGERY, V22, P369, DOI 10.1227/00006123-198802000-00016
   FRIEDMAN AH, 1986, J NEUROSURG, V65, P465, DOI 10.3171/jns.1986.65.4.0465
   Gadgil N, 2012, STEREOT FUNCT NEUROS, V90, P356, DOI 10.1159/000341072
   Galer BS, 1997, NEUROLOGY, V48, P332, DOI 10.1212/WNL.48.2.332
   Gebreyohanes AMH, 2021, OPER NEUROSURG, V20, P324, DOI 10.1093/ons/opaa447
   Guenot M, 2003, J CLIN NEUROPHYSIOL, V20, P143, DOI 10.1097/00004691-200304000-00009
   ISHIJIMA B, 1988, APPL NEUROPHYSIOL, V51, P175
   JEANMONOD D, 1989, ELECTROEN CLIN NEURO, V72, P450, DOI 10.1016/0013-4694(89)90050-3
   Ko AL, 2016, J NEUROSURG, V124, P1470, DOI 10.3171/2015.2.JNS142572
   KUMAGAI Y, 1992, ACTA NEUROCHIR, V115, P71, DOI 10.1007/BF01406361
   LEVY WJ, 1983, J NEUROSURG, V59, P884, DOI 10.3171/jns.1983.59.5.0884
   Liberati Alessandro, 2009, PLoS Med, V6, pe1000100, DOI 10.1371/journal.pmed.1000100
   Liu MX, 2015, STEREOT FUNCT NEUROS, V93, P178, DOI 10.1159/000375174
   LOESER JD, 1968, J NEUROSURG, V29, P48, DOI 10.3171/jns.1968.29.1.0048
   MOOSSY JJ, 1988, APPL NEUROPHYSIOL, V51, P198
   NASHOLD BS, 1981, J NEUROSURG, V55, P414, DOI 10.3171/jns.1981.55.3.0414
   NASHOLD BS, 1979, J NEUROSURG, V51, P59, DOI 10.3171/jns.1979.51.1.0059
   Nashold BS, 1982, MODERN NEUROSURGERY, V1, P460
   Pereira EAC, 2013, NEUROSURG FOCUS, V35, DOI 10.3171/2013.7.FOCUS1346
   Piyawattanametha N, 2017, ACTA NEUROCHIR, V159, P2431, DOI 10.1007/s00701-017-3345-3
   POWERS SK, 1988, APPL NEUROPHYSIOL, V51, P243
   Prestor B, 2006, CROAT MED J, V47, P271
   Prestor B, 2001, SURG NEUROL, V56, P259, DOI 10.1016/S0090-3019(01)00600-0
   Quinn TJ, 2017, FRONT NEUROL, V8, DOI 10.3389/fneur.2017.00275
   Rath SA, 1996, ACTA NEUROCHIR, V138, P364, DOI 10.1007/BF01420297
   Ruiz-Juretschke F, 2011, NEUROLOGIA, V26, P26, DOI 10.1016/j.nrl.2010.10.003
   Sakellariou Vasileios I, 2014, ISRN Orthop, V2014, P314137, DOI 10.1155/2014/314137
   Samii M, 2001, NEUROSURGERY, V48, P1269, DOI 10.1097/00006123-200106000-00016
   SAMII M, 1984, NEUROSURGERY, V15, P953, DOI 10.1227/00006123-198412000-00037
   SAMPSON JH, 1995, J NEUROSURG, V82, P28, DOI 10.3171/jns.1995.82.1.0028
   SARIS SC, 1985, J NEUROSURG, V62, P72, DOI 10.3171/jns.1985.62.1.0072
   SINDOU M, 1982, ADV PAIN RES THER, V4, P199
   SINDOU M, 1974, NEUROCHIRURGIE, V20, P391
   SINDOU M, 1974, J COMP NEUROL, V153, P15, DOI 10.1002/cne.901530103
   SINDOU M, 1995, ACTA NEUROCHIR, V137, P1, DOI 10.1007/BF02188771
   Sindou M, 2001, PAIN, V92, P159, DOI 10.1016/S0304-3959(00)00487-5
   SINDOU M, 1989, NEUROSURGERY, V24, P655, DOI 10.1227/00006123-198905000-00002
   Sindou MP, 2005, J NEUROSURG, V102, P1018, DOI 10.3171/jns.2005.102.6.1018
   Son BC, 2015, STEREOT FUNCT NEUROS, V93, P240, DOI 10.1159/000381556
   Spaic M., 2002, ACTA NEUROCHIR S, V144, P1092
   Suzuki R, 2005, NEUROSIGNALS, V14, P175, DOI 10.1159/000087656
   Takai K, 2017, J NEUROSURG-SPINE, V27, P178, DOI 10.3171/2017.1.SPINE16234
   Teixeira MJ, 2007, SPINE, V32, pE316, DOI 10.1097/01.brs.0000261541.97749.e7
   Teixeira MJ, 2015, BMC NEUROL, V15, DOI 10.1186/s12883-015-0329-x
   THOMAS DGT, 1984, NEUROSURGERY, V15, P966, DOI 10.1227/00006123-198412000-00040
   THOMAS DGT, 1994, J NEUROL NEUROSUR PS, V57, P737, DOI 10.1136/jnnp.57.6.737
   Yamanaka Hiroki, 2012, Brain and Nerve (Tokyo), V64, P1255
   YOUNG RF, 1990, J NEUROSURG, V72, P715, DOI 10.3171/jns.1990.72.5.0715
   ZEIDMAN SM, 1993, J SPINAL DISORD, V6, P44
   Zhang XH, 2008, CHINESE MED J-PEKING, V121, P1089
   Zheng Z, 2009, STEREOT FUNCT NEUROS, V87, P249, DOI 10.1159/000225978
NR 65
TC 16
Z9 19
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0303-8467
EI 1872-6968
J9 CLIN NEUROL NEUROSUR
JI Clin. Neurol. Neurosurg.
PD NOV
PY 2021
VL 210
AR 107004
DI 10.1016/j.clineuro.2021.107004
EA OCT 2021
PG 9
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA WS1ZS
UT WOS:000714988200004
PM 34739884
DA 2026-01-16
ER

PT J
AU Cózar, L
   Reyes, A
   Núñez, C
   López-Martínez, AE
   Serrano-Ibáñez, ER
   Esteve, R
   Marcos, E
   Ramírez-Maestre, C
AF Cozar, Luz
   Reyes, Angela
   Nunez, Cristina
   Lopez-Martinez, Alicia E.
   Serrano-Ibanez, Elena R.
   Esteve, Rosa
   Marcos, Estefania
   Ramirez-Maestre, Carmen
TI VARIABLES PSICOL?GICAS IMPLICADAS EN EL ABUSO O CONSUMO INDEBIDO DE
   OPIOIDES EN PACIENTES CON DOLOR CR?NICO NO ONCOL?GICO br
SO BEHAVIORAL PSYCHOLOGY-PSICOLOGIA CONDUCTUAL
LA English
DT Article
DE Self-enhancing humor; neuroticism; extraversion; chronic pain; opioids;
   abuse
ID CHRONIC PAIN PATIENTS; PRESCRIPTION; PREVALENCE; VALIDATION; MORTALITY;
   SCREENER; HEALTH; HUMOR
AB Psychological variables can be used to predict the risk of prescription opioid abuse. The aim of the present study was to analyse the predictive value of a set of these variables. Specifically, we analysed the association between the potential abuse and misuse of opioids and self-affirming mood, neuroticism, extraversion, anxiety and/or depression symptoms, and perceived pain intensity. The sample comprised 60 patients with chronic non-oncological pain (mean age= 60 years; 77% women, 78% married). Two stepwise multiple linear regression analyses were performed. The results indicate that anxiety and/or depression symptoms were the only variables associated with the potential abuse and current misuse of prescription opioids. We suggest the need for prior psychological assessment before deciding to initiate pharmacological therapy with opioids. Any anxiety or depression symptoms in these patients should be addressed before prescribing opioids.
C1 [Cozar, Luz; Reyes, Angela; Nunez, Cristina; Lopez-Martinez, Alicia E.; Serrano-Ibanez, Elena R.; Esteve, Rosa; Marcos, Estefania; Ramirez-Maestre, Carmen] Univ Malaga, Malaga, Spain.
C3 Universidad de Malaga
RP Serrano-Ibáñez, ER (corresponding author), Univ Malaga, Dept Personalidad Evaluac & Tratamiento Psicol, Fac Psicol, Malaga 29071, Spain.
EM elenarserrano@uma.es
RI Ramírez-Maestre, Carmen/L-9009-2014; Zarazaga, Mª/G-1442-2011; López
   Martínez, Alicia Eva/G-8834-2011; Serrano-Ibáñez, Elena R./AAB-5844-2021
OI Ramírez-Maestre, Carmen/0000-0002-3245-7844; 
CR Arteta J, 2016, PAIN MED, V17, P295, DOI 10.1111/pme.12886
   Breivik H, 2006, EUR J PAIN, V10, P287, DOI 10.1016/j.ejpain.2005.06.009
   Butler SF, 2008, J PAIN, V9, P360, DOI 10.1016/j.jpain.2007.11.014
   Butler SF, 2013, PAIN MED, V14, P1032, DOI 10.1111/pme.12098
   Butler SF, 2010, CLIN J PAIN, V26, P770, DOI 10.1097/AJP.0b013e3181f195ba
   Calvo-Falcón R., 2017, Rev. Soc. Esp. Dolor, V24, P313, DOI [10.20986/resed.2017.3550/2016, 10.20986/resed.2017.3550/2016]
   Camacho L., 2002, Revista de Psicologia de la Salud, V14, P3
   Chou R, 2009, J PAIN, V10, P131, DOI 10.1016/j.jpain.2008.10.009
   Cicero TJ, 2009, PAIN, V144, P20, DOI 10.1016/j.pain.2009.01.026
   Collado A., 2004, REV SOC ESPAR IOLA D, V11, P203
   Coloma-Carmona A, 2017, REV CLIN ESP, V217, P315, DOI 10.1016/j.rce.2017.03.007
   Dubey C., 2010, J INDIAN ACAD APPL P, V36, P107
   Dueñas M, 2015, PAIN MED, V16, P811, DOI 10.1111/pme.12640
   Mesas AE, 2011, MED CLIN-BARCELONA, V137, P55, DOI 10.1016/j.medcli.2010.09.006
   Domínguez MJF, 2018, ATEN PRIM, V50, P39, DOI 10.1016/j.aprim.2018.09.003
   Fernandez-Castillo A., 2007, BEHAV PSYCHOL, V15, P281
   Ferrari R, 2014, PAIN RES TREAT, V2014, DOI 10.1155/2014/584986
   Gatchel RJ, 2007, PSYCHOL BULL, V133, P581, DOI 10.1037/0033-2909.133.4.581
   Serecigni JG, 2018, ADICCIONES, V30, P87, DOI [10.20882/adicciones.936, 10.20882/adicciones.936, DOI 10.20882/ADICCIONES.936]
   Ibanez M.I., 1999, Analisis y Modificacion de Conducta, V25, P849
   Jaiswal A, 2016, HEALTHCARE-BASEL, V4, DOI 10.3390/healthcare4020034
   Jarana L., 1990, APUNTES PSICOLOGIA, V30, P17
   Jensen MP, 1999, PAIN, V83, P157, DOI 10.1016/S0304-3959(99)00101-3
   Kaiser U, 2017, PAIN, V158, P1853, DOI 10.1097/j.pain.0000000000000902
   Kaye AD, 2017, PAIN PHYSICIAN, V20, pS111
   Kornor H, 2007, BMC PSYCHIATRY, V7, DOI 10.1186/1471-244X-7-37
   Kumar A., 2015, INT J ED PSYCHOL RES, V4, P87
   Langley Paul C, 2011, J Med Econ, V14, P367, DOI 10.3111/13696998.2011.583303
   Carballo JL, 2016, PAPEL PSICOL, V37, P45
   Martin RA, 2003, J RES PERS, V37, P48, DOI 10.1016/S0092-6566(02)00534-2
   Martin RA, 2004, HUMOR, V17, P1, DOI 10.1515/humr.2004.005
   Mendiburo A., 2011, BOLET N PSICOLOG A, V102, P89
   Muriel J., 2018, Anales de la Real Academia Nacional de Farmacia, V84, P204
   Nordmann S, 2013, PAIN PHYSICIAN, V16, P89
   O'Brien T, 2017, EUR J PAIN, V21, P3, DOI 10.1002/ejp.970
   PARDO A., 2005, Analisis de datos con SPSS 13 Base
   Passik SD, 2011, PAIN MED, V12, pS36, DOI 10.1111/j.1526-4637.2011.01130.x
   Perez M., 2018, REV INVESTIGACION ED, V3, P2530, DOI [10.37536/RIECS.2018.3.1.71, DOI 10.37536/RIECS.2018.3.1.71]
   Pérez-Aranda A, 2019, EUR J PAIN, V23, P220, DOI 10.1002/ejp.1309
   Puebla Diaz F., 2005, Oncologia (Madrid), V28, P33
   Quintana JM, 2003, ACTA PSYCHIAT SCAND, V107, P216, DOI 10.1034/j.1600-0447.2003.00062.x
   Ramirez C., 2001, Anales de Psicologia, V17, P129
   Ramírez-Maestre C, 2020, EUR J PAIN, V24, P1357, DOI 10.1002/ejp.1583
   Ray WA, 2016, JAMA-J AM MED ASSOC, V315, P2415, DOI 10.1001/jama.2016.7789
   Rodríguez M. J., 2006, Rev. Soc. Esp. Dolor, V13, P525
   Espinar SS, 2016, Revista de PSICOLOGÍA DE LA SALUD, V4, P93, DOI [10.21134/pssa.v4i1.917, DOI 10.21134/PSSA.V4I1.703]
   Secades R., 2003, PSICOTHEMA, V15, P650
   Miñana JS, 2012, ATEN PRIM, V44, P335, DOI 10.1016/j.aprim.2011.06.009
   Soriano J., 2005, B PSICOL, V84, P91
   Sullivan MD, 2006, ARCH INTERN MED, V166, P2087, DOI 10.1001/archinte.166.19.2087
   Vicente-Herrero M.T., 2016, Rev. Soc. Esp. Dolor, V23, P64
   Vlaeyen JWS, 2000, PAIN, V85, P317, DOI 10.1016/S0304-3959(99)00242-0
   WASSERTHEIL S, 1970, BIOMETRICS, V26, P588, DOI 10.2307/2529115
   Wilsey BL, 2008, PAIN MED, V9, P1107, DOI 10.1111/j.1526-4637.2007.00401.x
NR 54
TC 0
Z9 0
U1 0
U2 8
PU FUNDACION VECA PARA AVANCE PSICOLOGIA
PI GRANADA
PA APARTADO CORREOS 1245, GRANADA, 18080, SPAIN
SN 1132-9483
J9 BEHAV PSYCHOL
JI Behav. Psychol.
PY 2022
VL 30
IS 2
BP 517
EP 532
DI 10.51668/bp.8322211s
PG 16
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 5A8BQ
UT WOS:000863107000001
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Miller, MC
AF Miller, Matthew C.
TI Complementary and Integrative Treatments Expanding the Continuum of Care
SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Complementary and alternative medicine; CAM; Integrative medicine; CIM;
   Otolaryngology; Traditional medicine; Acupuncture; Homeopathy natural
   products; Supplements
ID ALTERNATIVE MEDICINE USE; TRADITIONAL CHINESE MEDICINE; LOW-BACK-PAIN;
   CANCER-PATIENTS; UNITED-STATES; PHYSICIANS ATTITUDES; ADVISING PATIENTS;
   ACUPUNCTURE; THERAPIES; HEAD
AB This article is an introduction to the concepts of complementary, alternative, and integrative medicine. It discusses the scope and prevalence of complementary and integrative medicine (CIM) use among otolaryngology patients. Specific types of CIM are characterized in the context of their origins, philosophic and historical bases, scientific evidence, and applicability to the practice of otolaryngology. The author's intent is to provide a framework for discussing CIM with patients and integrating it into treatment paradigms in an evidence-based manner.
C1 Dept Otolaryngol Head & Neck Surg, Rochester, NY 14642 USA.
RP Miller, MC (corresponding author), Dept Otolaryngol Head & Neck Surg, Box 629,601 Elmwood Ave, Rochester, NY 14642 USA.
EM Matthew_miller@urmc.rochester.edu
CR Andersen BL, 2004, J CLIN ONCOL, V22, P3570, DOI 10.1200/JCO.2004.06.030
   [Anonymous], 2002, WHO TRADITIONAL MED
   Barnes Patricia M, 2008, Natl Health Stat Report, P1
   Blom M, 1996, ORAL ONCOL, V32B, P182
   Borsa PA, 1998, J ATHL TRAINING, V33, P150
   Bronfort Gert, 2004, Spine J, V4, P335, DOI 10.1016/j.spinee.2003.06.002
   Carlson LE, 2003, PSYCHOSOM MED, V65, P571, DOI 10.1097/01.PSY.0000074003.35911.41
   Cassileth BR, 2004, ONCOLOGIST, V9, P80, DOI 10.1634/theoncologist.9-1-80
   CHENG R, 1980, INT J NEUROSCI, V10, P95, DOI 10.3109/00207458009160487
   Chopra A, 2002, MED CLIN N AM, V86, P75, DOI 10.1016/S0025-7125(03)00073-7
   Cohen Andrea J, 2005, Integr Cancer Ther, V4, P131, DOI 10.1177/1534735405276419
   Collacott EA, 2000, JAMA-J AM MED ASSOC, V283, P1322, DOI 10.1001/jama.283.10.1322
   Davis GE, 2006, HEAD NECK-J SCI SPEC, V28, P926, DOI 10.1002/hed.20420
   DUNDEE JW, 1989, J ROY SOC MED, V82, P268, DOI 10.1177/014107688908200508
   Dy GK, 2004, J CLIN ONCOL, V22, P4810, DOI 10.1200/JCO.2004.03.121
   Eisenberg DM, 1997, ANN INTERN MED, V127, P61, DOI 10.7326/0003-4819-127-1-199707010-00010
   Eisenberg DM, 2002, ANN INTERN MED, V137, P965, DOI 10.7326/0003-4819-137-12-200212170-00010
   EISENBERG DM, 1993, NEW ENGL J MED, V328, P246, DOI 10.1056/NEJM199301283280406
   Eisenberg DM, 1998, JAMA-J AM MED ASSOC, V280, P1569, DOI 10.1001/jama.280.18.1569
   Ernst E, 2007, J ROY SOC MED, V100, P330, DOI 10.1258/jrsm.100.7.330
   Ernst E, 2003, EUR J CANCER, V39, P2273, DOI 10.1016/S0959-8049(03)00604-X
   Ernst E, 2002, BRIT J CLIN PHARMACO, V54, P577, DOI 10.1046/j.1365-2125.2002.01699.x
   Ezzo JM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002285.pub2
   Gouveia LO, 2009, SPINE, V34, pE405, DOI 10.1097/BRS.0b013e3181a16d63
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   Homola S, 2006, CLIN ORTHOP RELAT R, P236, DOI 10.1097/01.blo.0000200258.95865.87
   Hsiao AF, 2006, J ALTERN COMPLEM MED, V12, P1003, DOI 10.1089/acm.2006.12.1003
   Hyodo I, 2005, J CLIN ONCOL, V23, P2645, DOI 10.1200/JCO.2005.04.126
   Johnson SM, 2001, ACAD MED, V76, P821, DOI 10.1097/00001888-200108000-00016
   Johnstone PAS, 2001, INT J RADIAT ONCOL, V50, P353, DOI 10.1016/S0360-3016(00)01530-3
   Kawakita K, 2006, J PHARMACOL SCI, V100, P443, DOI 10.1254/jphs.CRJ06004X
   Kennedy J, 2008, EVID-BASED COMPL ALT, V5, P451, DOI 10.1093/ecam/nem045
   Khatri Deepali, 2007, Diabetes Res Clin Pract, V78, pe9, DOI 10.1016/j.diabres.2007.05.002
   Lafferty WE, 2004, CANCER-AM CANCER SOC, V100, P1522, DOI 10.1002/cncr.20105
   Linde K, 1997, LANCET, V350, P834, DOI 10.1016/S0140-6736(97)02293-9
   Manheimer E, 2009, J ALTERN COMPLEM MED, V15, P1001, DOI 10.1089/acm.2008.0414
   Milazzo S, 2006, EUR J CANCER, V42, P282, DOI 10.1016/j.ejca.2005.09.025
   Milden SP, 2004, BEHAV MED, V30, P73, DOI 10.3200/BMED.30.2.73-84
   Miller Matthew C, 2010, Ear Nose Throat J, V89, pE23
   Misra R, 2010, J ALTERN COMPLEM MED, V16, P843, DOI 10.1089/acm.2009.0517
   Molassiotis A, 2006, EUR J CANCER CARE, V15, P19, DOI 10.1111/j.1365-2354.2005.00615.x
   Nahin Richard L, 2009, Natl Health Stat Report, P1
   NANSEL D, 1995, J MANIP PHYSIOL THER, V18, P379
   Nidich SI, 2009, AM J HYPERTENS, V22, P1326, DOI 10.1038/ajh.2009.184
   Patwardhan B, 2005, EVID-BASED COMPL ALT, V2, P465, DOI 10.1093/ecam/neh140
   Pilkington K, 2011, J ALTERN COMPLEM MED, V17, P647, DOI 10.1089/acm.2010.0138
   Raimond K, 2003, INT J RADIAT ONCOL, V57, P472
   Riddle GNE, 2004, CAN FAM PHYSICIAN, V50, P871
   Rosa L, 1998, JAMA-J AM MED ASSOC, V279, P1005, DOI 10.1001/jama.279.13.1005
   Rubinstein SM, 2011, SPINE, V36, pE825, DOI 10.1097/BRS.0b013e3182197fe1
   Schmidt K, 2004, ANN ONCOL, V15, P733, DOI 10.1093/annonc/mdh174
   Shakeel M, 2007, INT J PEDIATR OTORHI, V71, P1725, DOI 10.1016/j.ijporl.2007.07.009
   Shakeel M, 2010, AM J OTOLARYNG, V31, P252, DOI 10.1016/j.amjoto.2009.02.016
   Sivasankaran S, 2006, CLIN CARDIOL, V29, P393, DOI 10.1002/clc.4960290905
   Smith MJ, 2002, MED CLIN N AM, V86, P173, DOI 10.1016/S0025-7125(03)00079-8
   Solberg EE, 2004, MED SCI MONITOR, V10, pCR96
   Stehlin I., 1996, FDA CONSUMER LINE ED, V30
   Swenson Rand, 2003, J Am Acad Orthop Surg, V11, P228
   Talmi YP, 2005, LARYNGOSCOPE, V115, P1505, DOI 10.1097/01.mlg.0000172205.31559.8d
   Thompson Trevor D B, 2006, BMC Complement Altern Med, V6, P37
   van der Weg F, 2003, SWISS MED WKLY, V133, P233
   Wahner-Roedler DL, 2006, EVID-BASED COMPL ALT, V3, P495, DOI 10.1093/ecam/nel036
   Warrick PD, 1999, ARCH OTOLARYNGOL, V125, P573, DOI 10.1001/archotol.125.5.573
   Waterbrook AL, 2010, J EMERG MED, V39, P569, DOI 10.1016/j.jemermed.2008.01.007
   Weiger WA, 2002, ANN INTERN MED, V137, P889, DOI 10.7326/0003-4819-137-11-200212030-00010
   Wolsko PM, 2004, J GEN INTERN MED, V19, P43, DOI 10.1111/j.1525-1497.2004.21019.x
   Wu APW, 2007, FAM MED, V39, P195
   Yates JS, 2005, SUPPORT CARE CANCER, V13, P806, DOI 10.1007/s00520-004-0770-7
   Yu Y, 1997, JPN J PHYSIOL, V47, P173, DOI 10.2170/jjphysiol.47.173
NR 69
TC 3
Z9 3
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0030-6665
EI 1557-8259
J9 OTOLARYNG CLIN N AM
JI Otolaryngol. Clin. N. Am.
PD JUN
PY 2013
VL 46
IS 3
BP 261
EP +
DI 10.1016/j.otc.2012.12.003
PG 17
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 175JL
UT WOS:000321226900001
PM 23764808
DA 2026-01-16
ER

PT J
AU Kwan, YH
   Fong, W
   Ang, XL
   Tan, CS
   Tai, BC
   Huang, YY
   Bilger, M
   Phang, JK
   Tan, HC
   Lee, JV
   Sun, LM
   Tan, CT
   Dong, BQ
   Koh, HL
   Leung, YY
   Lui, NL
   Yeo, SI
   Ng, SC
   Fong, KY
   Thumboo, J
   Ostbye, T
AF Kwan, Yu Heng
   Fong, Warren
   Ang, Xiang Ling
   Tan, Chuen Seng
   Tai, Bee Choo
   Huang, Youyi
   Bilger, Marcel
   Phang, Jie Kie
   Tan, Hui Chin
   Lee, Jia Ven
   Sun, Limin
   Tan, Choy Tip
   Dong, Bao Qiang
   Koh, Hwee Ling
   Leung, Ying Ying
   Lui, Nai Lee
   Yeo, Siaw Ing
   Ng, Swee Cheng
   Fong, Kok Yong
   Thumboo, Julian
   Ostbye, Truls
TI Traditional Chinese medicine (TCM) collaborative care for patients with
   axial spondyloarthritis (AcuSpA): protocol for a pragmatic randomized
   controlled trial
SO TRIALS
LA English
DT Article
ID HEALTH-ASSESSMENT QUESTIONNAIRE; ANKYLOSING-SPONDYLITIS;
   DISEASE-ACTIVITY; ALTERNATIVE MEDICINE; ACUPUNCTURE; COMPLEMENTARY;
   VALIDATION; MANAGEMENT; EFFICACY; VALIDITY
AB BackgroundAxial spondyloarthritis (AxSpA) is a chronic disease which results in fatigue, pain, and reduced quality of life (QoL). Traditional Chinese medicine (TCM), especially acupuncture, has shown promise in managing pain. Although a TCM collaborative model of care (TCMCMC) has been studied in cancer, there are no randomized controlled trials investigating TCM in AxSpA. Therefore, we will conduct a pragmatic trial to determine the clinical effectiveness, safety, and cost-effectiveness of TCMCMC for patients with AxSpA. We define TCMCMC as standard TCM history taking and physical examination, acupuncture, and TCM non-pharmacological advice and communications with rheumatologists in addition to usual rheumatologic care. The purpose of this paper is to describe the rationale for and methodology of this trial.Methods/designThis pragmatic randomized controlled trial will recruit 160 patients who are diagnosed with AxSpA and have inadequate response to non-steroidal anti-inflammatory drugs (NSAIDs). Simple randomization to usual rheumatologic care or the intervention (TCMCMC) with a 1:1 allocation ratio will be used. Ten 30-min acupuncture sessions will be provided to patients assigned to the TCMCMC arm. All participants will continue to receive usual rheumatologic care. The primary endpoint spinal pain will be evaluated at week 6. Secondary endpoints include clinical, quality of life, and economic outcome measures. Patients will be followed up for up to 52weeks, and adverse events will be documented.DiscussionThis trial may provide evidence regarding the clinical effectiveness, safety, and cost-effectiveness of a TCMCMC for patients with AxSpA.Trial registrationClinicalTrials.gov, NCT03420404. Registered on 14 February 2018.
C1 [Kwan, Yu Heng; Bilger, Marcel; Thumboo, Julian; Ostbye, Truls] Duke NUS Med Sch, Program Hlth Serv & Syst Res, Singapore, Singapore.
   [Fong, Warren; Phang, Jie Kie; Leung, Ying Ying; Lui, Nai Lee; Yeo, Siaw Ing; Ng, Swee Cheng; Fong, Kok Yong; Thumboo, Julian] Singapore Gen Hosp, Dept Rheumatol & Immunol, Acad Bldg,Level 4,20 Coll Rd, Singapore 169856, Singapore.
   [Fong, Warren; Leung, Ying Ying] Duke NUS Med Sch, Singapore, Singapore.
   [Fong, Warren] Natl Univ Singapore, Dept Med, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Ang, Xiang Ling; Tan, Hui Chin; Lee, Jia Ven; Sun, Limin; Tan, Choy Tip] Singapore Thong Chai Med Inst, Singapore, Singapore.
   [Tan, Chuen Seng; Tai, Bee Choo] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.
   [Huang, Youyi] SingHealth, Internal Med Residency, Singapore, Singapore.
   [Dong, Bao Qiang] Liaoning Univ Tradit Chinese Med, Shenyang, Liaoning, Peoples R China.
   [Koh, Hwee Ling] Natl Univ Singapore, Dept Pharm, Singapore, Singapore.
C3 National University of Singapore; Singapore General Hospital; National
   University of Singapore; National University of Singapore; National
   University of Singapore; Liaoning University of Traditional Chinese
   Medicine; National University of Singapore
RP Thumboo, J (corresponding author), Duke NUS Med Sch, Program Hlth Serv & Syst Res, Singapore, Singapore.; Thumboo, J (corresponding author), Singapore Gen Hosp, Dept Rheumatol & Immunol, Acad Bldg,Level 4,20 Coll Rd, Singapore 169856, Singapore.
EM yuheng@u.duke.nus.edu; julian.thumboo@singhealth.com.sg
RI Tan, Chuen/K-1078-2013; Yeo, Siaw Ing/ISA-4717-2023; Kwan, Yu
   Heng/I-4099-2019; Leung, Ying Ying/J-9099-2015; Fong, Warren/Q-8321-2019
OI Bilger, Marcel/0000-0002-2872-6597; Koh, Hwee-Ling/0000-0003-1461-9245;
   Kwan, Yu Heng/0000-0001-7802-9696; Ostbye, Truls/0000-0002-0662-7440;
   Leung, Ying Ying/0000-0001-8492-6342; 
FU Singapore's Ministry of Health Traditional Chinese Medicine Research
   Grant [TCMRG/SGH310301]
FX This trial is funded by Singapore's Ministry of Health Traditional
   Chinese Medicine Research Grant (TCMRG/SGH310301) (Email:
   MOH_TRAC_Secretariat@moh.gov.sg).The funder has not taken part in the
   study design, data collection and analysis, the decision to publish, or
   the preparation of the manuscript.
CR Asquith M, 2016, CURR OPIN RHEUMATOL, V28, P405, DOI 10.1097/BOR.0000000000000299
   Braun J, 2015, EXPERT REV CLIN IMMU, V11, P935, DOI 10.1586/1744666X.2015.1052795
   Bruce B, 2003, J RHEUMATOL, V30, P167
   Bruce Bonnie, 2003, Health Qual Life Outcomes, V1, P20, DOI 10.1186/1477-7525-1-20
   Bullock M L, 1997, J Altern Complement Med, V3, P31, DOI 10.1089/acm.1997.3.31
   Busija L, 2011, ARTHRIT CARE RES, V63, pS383, DOI 10.1002/acr.20541
   CALIN A, 1994, J RHEUMATOL, V21, P2281
   Camp A, 1998, MED ACUPUNCTURE W SC, P60
   Chen FP, 2007, BMC HEALTH SERV RES, V7, DOI 10.1186/1472-6963-7-26
   Cohen J, 1988, STAT POWER ANAL BEHA, DOI DOI 10.4324/9780203771587
   Cohen JD, 2006, J RHEUMATOL, V33, P79
   Dale J., 1997, Complementary Therapies in Medicine, V5, P215, DOI DOI 10.1016/S0965-2299(97)80032-5
   Efthimiou P, 2010, RHEUMATOL INT, V30, P571, DOI 10.1007/s00296-009-1206-y
   Elder WG, 2014, J AM BOARD FAM MED, V27, P846, DOI 10.3122/jabfm.2014.06.140042
   Ernst E, 2010, RHEUMATOLOGY, V49, P1957, DOI 10.1093/rheumatology/keq180
   Ferreira-Valente MA, 2011, PAIN, V152, P2399, DOI 10.1016/j.pain.2011.07.005
   Galloway JB, 2013, ANN RHEUM DIS, V72, P229, DOI 10.1136/annrheumdis-2011-201108
   GARRETT S, 1994, J RHEUMATOL, V21, P2286
   Godwin Marshall, 2003, BMC Med Res Methodol, V3, P28, DOI 10.1186/1471-2288-3-28
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Hays RD, 2001, ANN MED, V33, P350, DOI 10.3109/07853890109002089
   Johnson KE, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1158-y
   Jones SD, 1996, BRIT J RHEUMATOL, V35, P66
   Kiltz U, 2016, INTERNIST, V57, P1060, DOI 10.1007/s00108-016-0140-9
   Kwan YH, 2018, QUAL LIFE RES, V27, P2321, DOI 10.1007/s11136-018-1900-x
   Kwan YH, 2017, SEMIN ARTHRITIS RHEU, V47, P175, DOI 10.1016/j.semarthrit.2017.04.002
   Kwan YH, 2018, INT J RHEUM DIS, V21, P699, DOI 10.1111/1756-185X.12989
   Kwan Y, 2016, RHEUMATOL INT, V36, P1759, DOI 10.1007/s00296-016-3567-3
   Leung YY, 2017, BMC MUSCULOSKEL DIS, V18, DOI 10.1186/s12891-017-1715-x
   Li JH, 2017, J MED ECON, V20, P91, DOI 10.1080/13696998.2016.1227829
   Liang Fei-fan, 2016, Zhongguo Gu Shang, V29, P449
   Lim MK, 2005, COMPLEMENT THER MED, V13, P16, DOI 10.1016/j.ctim.2004.11.002
   Luo N, 2012, MED CARE, V50, P627, DOI 10.1097/MLR.0b013e31824d7471
   MacPherson H, 2006, COMPLEMENT THER MED, V14, P20, DOI 10.1016/j.ctim.2005.07.006
   MacPherson Hugh, 2010, J Evid Based Med, V3, P140, DOI 10.1111/j.1756-5391.2010.01086.x
   MacPherson H, 2012, BMC GASTROENTEROL, V12, DOI 10.1186/1471-230X-12-150
   Meng CF, 2003, RHEUMATOLOGY, V42, P1508, DOI 10.1093/rheumatology/keg405
   Nhan DT, 2016, RHEUM DIS CLIN N AM, V42, P285, DOI 10.1016/j.rdc.2016.01.011
   Phang JK, 2018, COMPLEMENT THER MED, V37, P143, DOI 10.1016/j.ctim.2018.03.003
   Png K, 2018, SEMIN ARTHRITIS RHEU, V48, P274, DOI 10.1016/j.semarthrit.2018.02.016
   Quinzanos I, 2015, CLIN EXP RHEUMATOL, V33, P146
   Ramiro S, 2014, ANN RHEUM DIS, V73, P529, DOI 10.1136/annrheumdis-2013-204575
   Ramonda R, 2016, ARTHRITIS RES THER, V18, DOI 10.1186/s13075-016-0977-2
   Rudwaleit M, 2009, ANN RHEUM DIS, V68, P777, DOI 10.1136/ard.2009.108233
   Sieper J, 2008, ANN RHEUM DIS, V67, P323, DOI 10.1136/ard.2007.075309
   Sieper J, 2009, ANN RHEUM DIS, V68, P1, DOI 10.1136/ard.2008.104018
   Sieper J, 2013, ANN RHEUM DIS, V72, P815, DOI 10.1136/annrheumdis-2012-201766
   Wee HL, 2004, CLIN THER, V26, P1137, DOI 10.1016/S0149-2918(04)90186-5
   Wong T W, 1995, Asia Pac J Public Health, V8, P167
   Zhang JH, 2010, B WORLD HEALTH ORGAN, V88, P915, DOI 10.2471/BLT.10.076737
   Zochling J, 2011, ARTHRIT CARE RES, V63, pS47, DOI 10.1002/acr.20575
   Zwarenstein M, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a2390
NR 52
TC 3
Z9 3
U1 1
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JAN 14
PY 2019
VL 20
AR 46
DI 10.1186/s13063-018-3117-2
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HH4FD
UT WOS:000455676000001
PM 30642381
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Heo, JS
   Yang, SY
   Lim, SA
   Lee, JM
   Kang, JY
   Sun, SH
   Kim, HG
   Kang, W
   Cho, JH
AF Heo, Je-Sin
   Yang, Su-Young
   Lim, Sung-Ah
   Lee, Jong-Moo
   Kang, Ji-Young
   Sun, Seung-Ho
   Kim, Hyeong-Geug
   Kang, Weechang
   Cho, Jung-Hyo
TI A manual acupuncture treatment attenuates common cold and its symptoms:
   a case series report from South Korea
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE Common cold; Hand acupuncture; Traditional Chinese Medicine therapy;
   Case reports
ID RANDOMIZED CONTROLLED-TRIAL; SUFFICIENTLY IMPORTANT DIFFERENCE; CANCER;
   PAIN; INFECTION; INFLUENZA; SEVERITY; COST
AB OBJECTIVE: To investigate beneficial effects of manual acupuncture on common cold periods and its symptoms depended on the difference onset time of common cold, within 36 h or over than that. To prove effects of manual acupuncture on common cold, a retrospective chart review was conducted.
   METHODS: Chart data for patients with common cold who were treated with only manual acupuncture with fulfilling Jackson scales and satisfaction at the end of each treatment were collected via multi-centers of Oriental hospitals, Oriental medicine clinics and covalent hospital in South Korea. Totally 187 patients were divided into two groups, Group I (115 patients, within 36 h) and Group II (72 patients, onset time of cold over than 36 h). Finally 120 patients were observed until entire resolution of cold symptoms.
   RESULTS: Group I showed significant decreases the median durations of completely recovery (3 days; 95% CI 3.0-4.0) as compared with Group II (6 days; 95% CI 4.0-7.0, P < 0.001). The manual acupuncture beneficially worked for reduction rate of common cold symptoms by 50% after initial treatment, decreased cold symptoms, and reduced cold duration.
   CONCLUSION: Manual acupuncture beneficially affected common cold and its symptoms. Moreover it is more susceptibility on the early time of onset cold. (C) 2016 JTCM. All rights reserved.
C1 [Heo, Je-Sin; Yang, Su-Young; Lee, Jong-Moo] Assoc Sang Su Med, Dept Acupuncture Therapy, Daejeon 301805, South Korea.
   [Lim, Sung-Ah] Daejeon Univ, Dept Beauty & Hlth Care, Coll Sports & Hlth Publ, Daejeon 300716, South Korea.
   [Kang, Ji-Young; Kim, Hyeong-Geug; Cho, Jung-Hyo] Daejeon Univ, Dept Internal Immune Ctr, Daejeon Oriental Hosp, Daejeon 301724, South Korea.
   [Sun, Seung-Ho] Sangji Univ, Dept Internal Med, Korean Med Hosp, Kangwon 220955, South Korea.
   [Kang, Weechang] Daejeon Univ, Dept Business Informat Stat, Coll Business Adm, Daejeon 300716, South Korea.
C3 Daejeon University; Daejeon University; Sangji University; Daejeon
   University
RP Cho, JH (corresponding author), Daejeon Univ, Dept Internal Immunol Ctr, Daejeon Oriental Hosp, Daejeon 301724, South Korea.
EM choa-joa@dju.kr
FU Educational Research (the Project of Intramural Research Supporting
   Program) from Daejeon University [201400950001]; Study of Acupuncture
   Therapy in Traditional Korean Medicine (Theory of the Acupuncture
   Lecture in South Korea) [2014-001A]
FX Supported by Educational Research in 2014 (the Project of Intramural
   Research Supporting Program, No. 201400950001) from Daejeon University;
   Study of Acupuncture Therapy in Traditional Korean Medicine (Theory of
   the Acupuncture Lecture in South Korea, No. 2014-001A)
CR Arroll B, 2005, COCHRANE DB SYST REV, V6
   Barrett B, 2005, MED DECIS MAKING, V25, P47, DOI 10.1177/0272989X04273147
   Barrett B, 2007, ANN FAM MED, V5, P216, DOI 10.1370/afm.698
   Barrett B, 2011, ANN FAM MED, V9, P312, DOI 10.1370/afm.1250
   Barrett B, 2010, ANN INTERN MED, V153, P769, DOI 10.7326/0003-4819-153-12-201012210-00003
   Barrett Bruce, 2007, WMJ, V106, P473
   Eccles R, 2005, LANCET INFECT DIS, V5, P718, DOI 10.1016/S1473-3099(05)70270-X
   Fendrick AM, 2003, ARCH INTERN MED, V163, P487, DOI 10.1001/archinte.163.4.487
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   Heikkinen T, 2003, LANCET, V361, P51, DOI 10.1016/S0140-6736(03)12162-9
   JACKSON GG, 1958, ARCH INTERN MED, V101, P267, DOI 10.1001/archinte.1958.00260140099015
   JACKSON GG, 1962, AM J PUBLIC HEALTH N, V56, P940, DOI 10.2105/AJPH.52.6.940
   Kawakita K, 2004, COMPLEMENT THER MED, V12, P181, DOI 10.1016/j.ctim.2004.10.004
   Kawakita K, 2008, EVID-BASED COMPL ALT, V5, P481, DOI 10.1093/ecam/nem055
   Plaster R, 2014, ACUPUNCT MED, V32, P236, DOI 10.1136/acupmed-2013-010489
   Prasad AS, 2008, J INFECT DIS, V197, P795, DOI 10.1086/528803
   SHAH CP, 1976, J OTOLARYNGOL, V5, P505
   Silva JG, 2014, J PHYS THER SCI, V26, P349, DOI 10.1589/jpts.26.349
   Simasek M, 2007, AM FAM PHYSICIAN, V75, P515
   Sung JJY, 2002, GUT, V51, P617, DOI 10.1136/gut.51.5.617
   Tas D, 2014, ASIAN PAC J CANCER P, V15, P3139, DOI 10.7314/APJCP.2014.15.7.3139
   Yakoot M, 2011, INT J GEN MED, V4, P45, DOI 10.2147/IJGM.S16266
   ZAPKA J, 1979, AM J PUBLIC HEALTH, V69, P814, DOI 10.2105/AJPH.69.8.814
   Zeng K, 2014, AM J CHINESE MED, V42, P289, DOI 10.1142/S0192415X14500190
NR 24
TC 0
Z9 2
U1 0
U2 8
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD DEC 15
PY 2016
VL 36
IS 6
BP 724
EP 729
DI 10.1016/S0254-6272(17)30006-7
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EF1LU
UT WOS:000390087100006
PM 29949334
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Zhang, XY
   Qiu, H
   Li, CS
   Cai, PP
   Qi, FH
AF Zhang, Xiaoyi
   Qiu, Hua
   Li, Chensheng
   Cai, Pingping
   Qi, Fanghua
TI The positive role of traditional Chinese medicine as an adjunctive
   therapy for cancer
SO BIOSCIENCE TRENDS
LA English
DT Review
DE Traditional Chinese Medicine (TCM); Chinese herbal medicines;
   acupuncture; cancer-related symptoms; anti-cancer therapy-related
   adverse reactions and complications
ID INDUCED PERIPHERAL NEUROPATHY; HERBAL MEDICINE; HANGESHASHINTO TJ-14;
   ADJUVANT TREATMENT; CHEMOTHERAPY; FATIGUE; GINSENG; INSOMNIA;
   PHARMACOLOGY; ACUPUNCTURE
AB Traditional Chinese medicine (TCM), especially Chinese herbal medicines and acupuncture, has been traditionally used to treat patients with cancers in China and other East Asian countries. Numerous studies have indicated that TCM not only alleviates the symptoms (e.g., fatigue, chronic pain, anorexia/ cachexia, and insomnia) of patients with cancer and improves their quality of life (QOL) but also diminishes adverse reactions and complications caused by chemotherapy, radiotherapy, or targetedtherapy. Therefore, Chinese herbal medicines and acupuncture and other alternative therapies need to be understood by TCM physicians and other health care providers. This review mainly summarizes the experimental results and conclusions from literature published since 2010, and a search of the literature as been performed in the PubMed, MEDLINE, Web of Science, Scopus, Springer, ScienceDirect, and China Hospital Knowledge Database (CHKD) databases. Some Chinese herbal medicines (e.g., Panax ginseng, Panax quinquefolius, Astragali radix, Bu-zhong-yi-qi-tang (TJ-41), Liu-jun-zi-tang (TJ-43), Shi-quan-da-bu-tang (TJ-48), and Ban-xia-xie-xin-tang (TJ-14)) and some acupuncture points (e.g., Zusanli (ST36), Zhongwan (CV12), Neiguan (PC6) and Baihui (GV20)) that are commonly used to treat cancer-related symptoms and/or to reduce the toxicity of chemotherapy, radiotherapy, or targeted-therapy are highlighted and summarized. Through a review of literature, we conclude that TCM can effectively alleviate adverse gastrointestinal reactions (including diarrhea, nausea, and vomiting) to these anti-cancer therapies, decrease the incidence of bone marrow suppression, alleviate cardiotoxicity, and protect against chemotherapy-induced peripheral neuropathy and radiation-induced pneumonitis. Moreover, TCM can alleviate epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-related acneiform eruptions, diarrhea, and other adverse reactions. The hope is that this review can contribute to an understanding of TCM as an adjuvant therapy for cancer and that it can provide useful information for the development of more effective anti-cancer therapies. However, more rigorously designed trials involving cancer treatment must be conducted in the future, including complete quality control and standardized models at the cellular, organic, animal and clinical levels, in order to study TCM in multiple forms and at multiple levels.
C1 [Zhang, Xiaoyi; Cai, Pingping; Qi, Fanghua] Shandong First Med Univ, Shandong Prov Hosp, Tradit Chinese Med, Jinan, Peoples R China.
   [Qiu, Hua] Jinan Municipal Hosp Tradit Chinese Med, Gynecol, Jinan, Peoples R China.
   [Li, Chensheng] Shandong First Med Univ, Gastrointestinal Surg, Shandong Prov Hosp, Jinan, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong First Medical University & Shandong Academy of
   Medical Sciences
RP Qi, FH (corresponding author), Shandong First Med Univ, Shandong Prov Hosp, Tradit Chinese Med, Jinan, Peoples R China.
EM qifanghua2006@126.com
RI qi, fang/OYE-3690-2025; cai, pingping/ODL-7630-2025
FU National Natural Science Foundation of China [81603449]; Natural Science
   Foundation of Shandong Province [ZR2015HQ015]; Shandong Province Plan
   for Scientific and Technological Development of Traditional Chinese
   Medicine [20190310]
FX This study was funded by the National Natural Science Foundation of
   China (grant No. 81603449), the Natural Science Foundation of Shandong
   Province (grant No. ZR2015HQ015), and the Shandong Province Plan for
   Scientific and Technological Development of Traditional Chinese Medicine
   (grant No. 20190310).
CR Arring NM, 2019, CANCER J, V25, P349, DOI 10.1097/PPO.0000000000000396
   Babiker HM, 2018, CRIT REV ONCOL HEMAT, V126, P186, DOI 10.1016/j.critrevonc.2018.03.014
   Barton DL, 2013, JNCI-J NATL CANCER I, V105, P1230, DOI 10.1093/jnci/djt181
   Behzadmehr R, 2020, COMPLEMENT THER MED, V49, DOI 10.1016/j.ctim.2020.102318
   Bennett MI, 2019, PAIN, V160, P38, DOI 10.1097/j.pain.0000000000001363
   Berger Ann M, 2015, J Natl Compr Canc Netw, V13, P1012
   Bledsoe TJ, 2017, CLIN CHEST MED, V38, P201, DOI 10.1016/j.ccm.2016.12.004
   Cai PL, 2018, MEDICINE, V97, DOI [10.1097/md.0000000000009965, 10.1097/MD.0000000000009965]
   Cai PP, 2019, BIOSCI TRENDS, V13, P367, DOI 10.5582/bst.2019.01244
   Cao MM, 2020, CANCER COMMUN, V40, P205, DOI 10.1002/cac2.12025
   Chang YD, 2018, AM J HOSP PALLIAT ME, V35, P144, DOI 10.1177/1049909117695733
   Chen HY, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-362
   Chen ZJ, 2020, J ETHNOPHARMACOL, V258, DOI 10.1016/j.jep.2020.112895
   Cheng KC, 2012, CURR PHARM DESIGN, V18, P4819, DOI 10.2174/138161212803216979
   Cheng XL, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00344
   Cheon C, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-021242
   Cheon C, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/8780325
   Chiu HY, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12457
   Chung VCH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002793
   Cui YM, 2018, BIOMED PHARMACOTHER, V108, P1081, DOI 10.1016/j.biopha.2018.09.095
   Dan WC, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/7498525
   Davis MP, 2014, CANCER J, V20, P330, DOI 10.1097/PPO.0000000000000071
   Deng B, 2016, J CHINA JAPAN FRIEND, V30, P30, DOI DOI 10.3969/J.ISSN.1001-0025.2016.01.009
   Deng B, 2017, J TRADIT CHIN MED, V37, P35
   Fallon M, 2018, ANN ONCOL, V29, P166, DOI 10.1093/annonc/mdy152
   Fu J, 2014, PHYTOTHER RES, V28, P1275, DOI 10.1002/ptr.5188
   Fu L, 2014, CHIN CLIN ONCOL, V19, P739
   Ghosh R, 2020, MOLECULES, V25, DOI 10.3390/molecules25245854
   Gu JL, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/2363262
   He HL, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/426207
   He Q, 2020, BIOL PHARM BULL, V43, P110, DOI 10.1248/bpb.b19-00616
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Herrmann J, 2014, TRENDS CARDIOVAS MED, V24, P285, DOI 10.1016/j.tcm.2014.07.003
   Hulvat MC, 2020, SURG CLIN N AM, V100, P469, DOI 10.1016/j.suc.2020.01.002
   Ichiki M, 2017, ONCOTARGETS THER, V10, P5107, DOI 10.2147/OTT.S145613
   Ishiura Yoshihisa, 2016, Gan To Kagaku Ryoho, V43, P331
   Jain Diwakar, 2019, Hosp Pract (1995), V47, P6, DOI [10.1080/21548331.2018.1530831, 10.1080/21548331.2018.1530831]
   Jeong JS, 2010, INTEGR CANCER THER, V9, P331, DOI 10.1177/1534735410383170
   Johannes CM, 2019, VET CLIN N AM-SMALL, V49, P837, DOI 10.1016/j.cvsm.2019.04.008
   Kawai H, 2020, MOL CLIN ONCOL, V13, DOI 10.3892/mco.2020.2083
   Kiefer D, 2003, AM FAM PHYSICIAN, V68, P1539
   Kim JW, 2020, EUR J CANCER, V130, P51, DOI 10.1016/j.ejca.2020.02.018
   Kim KI, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0198015
   Ko MH, 2021, INTEGR CANCER THER, V20, DOI 10.1177/15347354211019107
   Lam TY, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1838-5
   Li FZ, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019330
   Li TM, 2018, J ETHNOPHARMACOL, V213, P92, DOI 10.1016/j.jep.2017.10.031
   Li Wanying, 2018, Zhongguo Zhen Jiu, V38, P695, DOI 10.13703/j.0255-2930.2018.07.003
   Liou KT, 2019, PAIN MED, V20, P2060, DOI 10.1093/pm/pnz087
   Litscher G, 2002, LASER MED SCI, V17, P19, DOI 10.1007/s10103-002-8262-9
   Liu MX, 2014, J ETHNOPHARMACOL, V152, P575, DOI 10.1016/j.jep.2014.02.012
   Lv C, 2018, CURR OPIN SUPPORT PA, V12, P174, DOI 10.1097/SPC.0000000000000348
   Ma SJ, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1037-9
   Madeddu Clelia, 2012, Critical Reviews in Oncogenesis, V17, P305
   Metri Kashinath, 2013, J Stem Cells, V8, P115
   Minagawa Tomonori, 2019, Nihon Hinyokika Gakkai Zasshi, V110, P86, DOI [10.5980/jpnjurol.110.86, 10.5980/jpnjurol.110.86]
   Mohandas H, 2017, J CANCER RES THER, V13, P916, DOI 10.4103/jcrt.JCRT_50_17
   Murai T, 2020, J RADIAT RES, V61, P140, DOI 10.1093/jrr/rrz025
   Nishikawa K, 2018, J CANCER, V9, P1725, DOI 10.7150/jca.24733
   O'Brien K, 2016, J ALTERN COMPLEM MED, V22, P684, DOI 10.1089/acm.2016.0044
   O'Donnell Joseph F, 2004, Clin Cornerstone, V6 Suppl 1D, pS6, DOI 10.1016/S1098-3597(05)80002-X
   Ozawa N, 2020, CANCER MANAG RES, V12, P1069, DOI 10.2147/CMAR.S238306
   Peng YM, 2018, BIOSCI TRENDS, V12, P537, DOI 10.5582/bst.2018.01246
   Qi FH, 2015, BIOSCI TRENDS, V9, P16, DOI 10.5582/bst.2015.01019
   Qi FH, 2010, BIOSCI TRENDS, V4, P297
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Shergis JL, 2017, PHYTOMEDICINE, V34, P38, DOI 10.1016/j.phymed.2017.07.004
   Staff NP, 2017, ANN NEUROL, V81, P772, DOI 10.1002/ana.24951
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Tian B, 2020, PHARM BIOL, V58, P265, DOI 10.1080/13880209.2020.1741651
   Urushiyama H, 2018, J CLIN MED, V7, DOI 10.3390/jcm7090246
   Walker WH, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20112780
   Wang Ya-Ling, 2019, Zhongguo Zhen Jiu, V39, P1269, DOI 10.13703/j.0255-2930.2019.12.004
   Wang YS, 2020, BIOMED PHARMACOTHER, V121, DOI 10.1016/j.biopha.2019.109570
   Wang ZX, 2018, BIOSCI TRENDS, V12, P220, DOI 10.5582/bst.2018.01144
   World Health Organization, which the slaves who risked torture and death to escape North
   Wu BY, 2015, COMPLEMENT THER MED, V23, P251, DOI 10.1016/j.ctim.2015.01.006
   Xiao H, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000025848
   Xiao Z, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004517
   Xu LL, 2021, MOLECULES, V26, DOI 10.3390/molecules26134000
   Xu RH, 2020, PHARMACOL RES, V152, DOI 10.1016/j.phrs.2019.104623
   Yan ZK, 2017, COMB CHEM HIGH T SCR, V20, P423, DOI 10.2174/1386207320666170116141818
   Yennurajalingam S, 2015, INTEGR CANCER THER, V14, P419, DOI 10.1177/1534735415580676
   Zhou QH, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00076
NR 84
TC 307
Z9 354
U1 40
U2 217
PU IRCA-BSSA
PI TOKYO
PA PEARL CITY KOISHIKAWA 603, 2-4-5 KASUGA, BUNKYO-KU, TOKYO, 112-0003,
   JAPAN
SN 1881-7815
EI 1881-7823
J9 BIOSCI TRENDS
JI BioSci. Trends
PD OCT
PY 2021
VL 15
IS 5
BP 283
EP 298
DI 10.5582/bst.2021.01318
EA AUG 2021
PG 16
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA WX4FW
UT WOS:000697085800001
PM 34421064
OA gold
DA 2026-01-16
ER

PT J
AU Gu, SH
   Lang, HB
   Gan, JH
   Zheng, ZW
   Zhao, F
   Tu, Q
AF Gu, Shuhan
   Lang, Hebin
   Gan, Jianhui
   Zheng, Zhiwen
   Zhao, Fang
   Tu, Qing
TI Effect of transcutaneous electrical acupoint stimulation on
   gastrointestinal function recovery after laparoscopic radical
   gastrectomy - A randomized controlled trial
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Transcutaneous electrical acupoint stimulation; Laparoscopic radical
   gastrectomy; Analgesia; Gastrointestinal function recovery; Enhanced
   recovery after surgery; Randomized controlled trial
ID ENHANCED RECOVERY; POSTOPERATIVE NAUSEA; ACUPUNCTURE POINTS;
   GASTRIC-CANCER; SURGERY; ANALGESIA; ELECTROACUPUNCTURE; PATHWAY
AB Introduction: Acupuncture is widely used as perioperative analgesia and promotes postoperative physical recovery. Transcutaneous electrical acupoint stimulation (TEAS) is a acupuncture method that has many advantages. However, there has been little study on the application of TEAS in laparoscopic radical gastrectomy. This is a study exploring the effects of TEAS on gastrointestinal function recovery after laparoscopic radical gastrectomy in order to provide a stimulation model for clinical use.
   Methods: A total of 120 gastric cancer patients undergoing laparoscopic radical gastrectomy were randomly assigned into the long duration TEAS (L-TEAS) group, or the placebo-control (C-TEAS) group. All patients were routinely anesthetized. For the L-TEAS group TEAS was maintained from 30 min before anesthetic induction to 30 min after the operation, and TEAS was also performed for 30 min at 8 a.m., 1 p.m. and 6 p.m. within 2 d of the operation. But in the C-TEAS group, the output wires of the stimulator were broken. The stimulation sites included bilateral Zusanli (ST 36) and Neiguan (PC 6) acupoints. Postoperatively, the patients received patient-controlled intravenous analgesia (PCIA). The consumption of analgesics as well as the scores of the visual analogue scale (VAS) and Ramsay Sedation Scale (RSS) at 4 h (T1), 8 h (T2), 16 h (T3), 24 h (T4) and 36 h (T5) were observed and recorded after the operation in the 2 groups. The duration of first bowel sounds, flatus and defecation were recorded after the operation. The incidence of postoperative nausea and vomiting (PONV) as well as patient satisfaction was recorded.
   Results: Compared to the C-TEAS group, the VAS scores at 4 h (2.79 +/- 0.48 vs. 3.41 +/- 0.62), 8 h (2.65 +/- 0.42 vs. 3.17 +/- 0.49), and 24 h (1.98 +/- 0.39 vs. 2.72 +/- 0.73) were significantly decreased in the L-TEAS group (P < 0.05) after the operation. Compared to the C-TEAS group, analgesic consumption at 4 h (10.02 +/- 2.26 vs. 13.38 +/- 2.98), 8 h (20.55 +/- 4.59 vs. 24.63 +/- 3.94) and 36 h (72.64 +/- 9.74 vs. 76.01 +/- 10.43) was significantly decreased in the L-TEAS group (P < 0.05) after the operation. There was a significant difference in the incidence of PONV between the L-TEAS (12%) and C-TEAS (32.2%) groups (P < 0.05). No significant difference was observed with respect to RSS among the 2 groups (P > 0.05). The time intervals from surgery to the first bowel sounds as well as the passage of flatus and defecation were shorter in the L-TEAS group than in the C-TEAS group (19.69 +/- 7.61 h vs. 26.58 +/- 7.43 h, 36.58 +/- 10.75 h vs. 43.56 +/- 9.57 h and 71.48 +/- 20.62 h vs. 77.27 +/- 22.67 h, respectively) (P < 0.05). The rate of moderately satisfaction and above in the L-TEAS (67.3%) group was higher than for that in the C-TEAS group (42.4%), and for very satisfied, the LTEAS (55.2%) group was higher than that in the C-TEAS group (15.3%) (P < 0.05).
   Conclusions: Preoperative TEAS and sustained TEAS within 2 d of the operation can effectively reduce the early postoperative pain, reduce the early postoperative consumption of analgesics, the total consumption of anesthetics, and the incidence of PONV as well as shorten the duration of first bowel sounds, first flatus and first defecation after the operation, promoting the recovery of gastrointestinal function and improving the patient satisfaction rate.
C1 [Gu, Shuhan; Gan, Jianhui; Zheng, Zhiwen; Zhao, Fang; Tu, Qing] North China Univ Sci & Technol, Tangshan Peoples Hosp, Dept Anesthesiol, 65 Shengli Rd, Tangshan 063000, Hebei, Peoples R China.
   [Lang, Hebin] North China Univ Sci & Technol, Tangshan Peoples Hosp, Dept Med Oncol, 65 Shengli Rd, Tangshan 063000, Hebei, Peoples R China.
C3 North China University of Science & Technology; North China University
   of Science & Technology
RP Gan, JH (corresponding author), North China Univ Sci & Technol, Tangshan Peoples Hosp, Dept Anesthesiol, 65 Shengli Rd, Tangshan 063000, Hebei, Peoples R China.
EM shuhangu@foxmail.com; 990320812@qq.com; ganjianhui888@126.com;
   zhiwen456@126.com; fangzhao668@163.com; qingtu1021@126.com
OI gu, shuhan/0000-0002-4138-9222
CR Abdikarim I, 2015, WORLD J GASTROENTERO, V21, P13339, DOI 10.3748/wjg.v21.i47.13339
   Apfel CC, 2012, BRIT J ANAESTH, V109, P742, DOI 10.1093/bja/aes276
   Braga M, 2014, WORLD J SURG, V38, P2960, DOI 10.1007/s00268-014-2653-5
   Chang CS, 2001, DIGESTION, V64, P184, DOI 10.1159/000048860
   Chiu C, 2018, BMC ANESTHESIOL, V18, DOI 10.1186/s12871-018-0505-9
   Ciardulli A, 2018, J MATERN-FETAL NEO M, V31, P1924, DOI 10.1080/14767058.2017.1330883
   Emmiler M, 2008, HEART SURG FORUM, V11, pE300, DOI 10.1532/HSF98.20081083
   Feldheiser A., 2016, ACTA ANAESTHESIOL SC
   Huang S, 2017, J ANESTH, V31, P58, DOI 10.1007/s00540-015-2057-1
   Hughes MJ, 2015, BRIT J SURG, V102, P1619, DOI 10.1002/bjs.9949
   Kranke P, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009642.pub2
   Lee CH, 2012, J ACUPUNCT MERIDIAN, V5, P63, DOI 10.1016/j.jams.2012.01.002
   Lee S, 2018, J GASTRIC CANCER, V18, P152
   Lee S, 2013, CHIN J INTEGR MED, V19, P277, DOI 10.1007/s11655-013-1425-7
   Leung WW, 2013, WORLD J GASTROENTERO, V19, P381, DOI 10.3748/wjg.v19.i3.381
   Li JF, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000008036
   Lin XM, 1997, AM J GASTROENTEROL, V92, P1527
   Lu Z, 2015, BRIT J ANAESTH, V115, P183, DOI 10.1093/bja/aev227
   Lundeberg T., 2015, MECH ACUPUNCTURE PAI
   Lv JQ, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-153
   MacPherson H, 2002, J ALTERN COMPLEM MED, V8, P85, DOI 10.1089/107555302753507212
   Noroozinia Heydar, 2013, Acta Med Iran, V51, P163
   Park JY, 2018, TOXINS, V10, DOI 10.3390/toxins10040163
   Praveena Seevaunnamtum S., 2016, ANESTHESIOLOGY PAIN, V6, DOI [10.5812/aapm.40106, DOI 10.5812/AAPM.40106]
   Sun R., 2014, EVID-BASED COMPL ALT
   Susan M., 2017, J SURG ONCOL, V116
   Tatic Milanka, 2003, Med Pregl, V56, P431, DOI 10.2298/MPNS0310431T
   Tu Q, 2019, UROLITHIASIS, V47, P279, DOI 10.1007/s00240-018-1056-8
   Wang LH, 2018, WORLD J GASTROENTERO, V24, P1562, DOI 10.3748/wjg.v24.i14.1562
   White PF, 2007, ANESTH ANALG, V104, P1380, DOI 10.1213/01.ane.0000263034.96885.e1
   Xue CCL, 2012, TRIALS, V13, DOI 10.1186/1745-6215-13-169
   Yeoh AH, 2016, TURK J MED SCI, V46, P620, DOI 10.3906/sag-1502-56
   Zhang ZD, 2014, ACUPUNCT MED, V32, P223, DOI 10.1136/acupmed-2013-010490
   Zhou DD, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/7341920
NR 34
TC 13
Z9 13
U1 7
U2 72
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD FEB
PY 2019
VL 26
BP 11
EP 17
DI 10.1016/j.eujim.2019.01.001
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA HP9XL
UT WOS:000462046300002
DA 2026-01-16
ER

PT J
AU Cohen, L
   Danhauer, SC
   Garcia, MK
   Dressler, EV
   Rosenthal, DI
   Chambers, MS
   Cusimano, A
   Brown, WM
   Ochoa, JM
   Yang, PY
   Chiang, JS
   Gordon, O
   Crutcher, R
   Kim, JK
   Russin, MP
   Lukenbill, J
   Porosnicu, M
   Yost, KJ
   Weaver, KE
   Lesser, GJ
AF Cohen, Lorenzo
   Danhauer, Suzanne C.
   Garcia, M. Kay
   Dressler, Emily V.
   Rosenthal, David I.
   Chambers, Mark S.
   Cusimano, Andrew
   Brown, W. Mark
   Ochoa, Jewel M.
   Yang, Peiying
   Chiang, Joseph S.
   Gordon, Ora
   Crutcher, Rhonda
   Kim, Jung K.
   Russin, Michael P.
   Lukenbill, Joshua
   Porosnicu, Mercedes
   Yost, Kathleen J.
   Weaver, Kathryn E.
   Lesser, Glenn J.
TI Acupuncture for Chronic Radiation-Induced Xerostomia in Head and Neck
   Cancer: A Multicenter Randomized Clinical Trial
SO JAMA NETWORK OPEN
LA English
DT Article
ID SENSORY STIMULATION ACUPUNCTURE; QUALITY-OF-LIFE; INTENSITY-MODULATED
   IRRADIATION; AURICULAR ACUPUNCTURE; HIP-ARTHROPLASTY; PAIN RELIEF;
   PHASE-III; VALIDATION; PREVENTION; SALIVARY
AB Importance Patients with head and neck cancer who undergo radiotherapy can develop chronic radiation-induced xerostomia. Prior acupuncture studies were single center and rated as having high risk of bias, making it difficult to know the benefits of acupuncture for treating radiation-induced xerostomia. Objective To compare true acupuncture (TA), sham acupuncture (SA), and standard oral hygiene (SOH) for treating radiation-induced xerostomia. Design, Setting, and Participants A randomized, blinded, 3-arm, placebo-controlled trial was conducted between July 29, 2013, and June 9, 2021. Data analysis was performed from March 9, 2022, through May 17, 2023. Patients reporting grade 2 or 3 radiation-induced xerostomia 12 months or more postradiotherapy for head and neck cancer were recruited from community-based cancer centers across the US that were part of the Wake Forest National Cancer Institute Community Oncology Research Program Research Base. Participants had received bilateral radiotherapy with no history of xerostomia. Interventions Participants received SOH and were randomized to TA, SA, or SOH only. Participants in the TA and SA cohorts were treated 2 times per week for 4 weeks. Those experiencing a minor response received another 4 weeks of treatment. Main Outcomes and Measures Patient-reported outcomes for xerostomia (Xerostomia Questionnaire, primary outcome) and quality of life (Functional Assessment of Cancer Therapy-General) were collected at baseline, 4 (primary time point), 8, 12, and 26 weeks. All analyses were intention to treat. Results A total of 258 patients (201 men [77.9%]; mean [SD] age, 65.0 [9.16] years), participated from 33 sites across 13 states. Overall, 86 patients were assigned to each study arm. Mean (SD) years from diagnosis was 4.21 (3.74) years, 67.1% (n = 173) had stage IV disease. At week 4, Xerostomia Questionnaire scores revealed significant between-group differences, with lower Xerostomia Questionnaire scores with TA vs SOH (TA: 50.6; SOH: 57.3; difference, -6.67; 95% CI, -11.08 to -2.27; P = .003), and differences between TA and SA (TA: 50.6; SA: 55.0; difference, -4.41; 95% CI, -8.62 to -0.19; P = .04) yet did not reach statistical significance after adjustment for multiple comparisons. There was no significant difference between SA and SOH. Group differences in Functional Assessment of Cancer Therapy-General scores revealed statistically significant group differences at week 4, with higher scores with TA vs SOH (TA: 101.6; SOH: 97.7; difference, 3.91; 95% CI, 1.43-6.38; P = .002) and at week 12, with higher scores with TA vs SA (TA: 102.1; SA: 98.4; difference, 3.64; 95% CI, 1.10-6.18; P = .005) and TA vs SOH (TA: 102.1; SOH: 97.4; difference, 4.61; 95% CI, 1.99-7.23; P = .001). Conclusions and Relevance The findings of this trial suggest that TA was more effective in treating chronic radiation-induced xerostomia 1 or more years after the end of radiotherapy than SA or SOH. Trial RegistrationClinicalTrials.gov Identifier: NCT02589938
C1 [Cohen, Lorenzo; Garcia, M. Kay; Cusimano, Andrew; Ochoa, Jewel M.; Yang, Peiying] Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, 1515 Holcombe Blvd,Unit 1414, Houston, TX 77030 USA.
   [Danhauer, Suzanne C.; Weaver, Kathryn E.] Wake Forest Univ, Sch Med, Dept Social Sci & Hlth Policy, Winston Salem, NC USA.
   [Dressler, Emily V.; Brown, W. Mark] Wake Forest Univ, Sch Med, Dept Biostat & Data Sci, Winston Salem, NC 27157 USA.
   [Rosenthal, David I.] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX USA.
   [Chambers, Mark S.] Univ Texas MD Anderson Canc Ctr, Dept Dent Oncol, Houston, TX 77030 USA.
   [Chiang, Joseph S.] Univ Texas MD Anderson Canc Ctr, Dept Anesthesiol, Houston, TX USA.
   [Gordon, Ora; Crutcher, Rhonda; Kim, Jung K.] Disney Family Canc Ctr, Providence St Joseph Med Ctr, Dept Integrat Med, Burbank, CA USA.
   [Russin, Michael P.] Kaiser Permanente Diablo Serv Area, Martinez, CA USA.
   [Lukenbill, Joshua] Iowa Wide Oncol Res Coalit NCORP, Des Moines, IA USA.
   [Porosnicu, Mercedes; Lesser, Glenn J.] Wake Forest Univ, Sch Med, Dept Internal Med, Sect Hematol & Oncol, Winston Salem, NC USA.
   [Yost, Kathleen J.] Canc Res Consortium West Michigan NCORP, Spectrum Hlth Butterworth Campus, Grand Rapids, MI USA.
C3 University of Texas System; UTMD Anderson Cancer Center; Wake Forest
   University; Wake Forest University; University of Texas System; UTMD
   Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer
   Center; University of Texas System; UTMD Anderson Cancer Center; Kaiser
   Permanente; Wake Forest University
RP Cohen, L (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, 1515 Holcombe Blvd,Unit 1414, Houston, TX 77030 USA.
EM lcohen@mdanderson.org
RI Weaver, Kathryn/W-3258-2019; Chambers, Mark/C-9470-2009
OI Gordon, Ora/0009-0002-2084-7914; McBride, Kelly Ann/0009-0007-8873-0778
FU National Cancer Institute (NCI) [UG1CA189824, U10CA045809, R01CA160880];
   NCI Cancer Center Support [CA016672]; Richard E. Haynes Distinguished
   Professorship for Clinical Cancer Prevention at The University of Texas
   MD Anderson Cancer Center
FX Support was provided in part by National Cancer Institute (NCI) grants
   UG1CA189824, U10CA045809, R01CA160880, and the NCI Cancer Center Support
   grant CA016672. Partial funding was provided by the Richard E. Haynes
   Distinguished Professorship for Clinical Cancer Prevention at The
   University of Texas MD Anderson Cancer Center (Dr Cohen).
CR Andersen SW, 1997, ORAL ONCOL, V33, P146, DOI 10.1016/S0964-1955(96)00058-9
   [Anonymous], 2017, National Cancer Institute Common Terminology Criteria for Adverse Events v5.0 NCI
   [Anonymous], 2023, SASSTAT 153 USERS GU
   Bertram U., 1967, Acta Odontol Scand, V25, P49
   Blom M, 1996, ORAL ONCOL, V32B, P182
   BLOM M, 1993, J ORAL REHABIL, V20, P541, DOI 10.1111/j.1365-2842.1993.tb01641.x
   Blom M, 2000, ORAL DIS, V6, P15
   Brizel DM, 2000, J CLIN ONCOL, V18, P3339, DOI 10.1200/JCO.2000.18.19.3339
   CELLA DF, 1993, J CLIN ONCOL, V11, P570, DOI 10.1200/JCO.1993.11.3.570
   Chambers MS, 2007, HEAD NECK-J SCI SPEC, V29, P58, DOI 10.1002/hed.20456
   Cho JH, 2008, J ALTERN COMPLEM MED, V14, P523, DOI 10.1089/acm.2007.0793
   Cohen L, 2022, J CLIN ONCOL, V40
   Menezes ASD, 2021, OR SURG OR MED OR PA, V131, P675, DOI 10.1016/j.oooo.2021.02.016
   Dawidson I, 1999, NEUROPEPTIDES, V33, P244, DOI 10.1054/npep.1999.0759
   Dawidson I, 1998, LIFE SCI, V63, P659, DOI 10.1016/S0024-3205(98)00317-8
   Dawidson I, 1998, NEUROPEPTIDES, V32, P543, DOI 10.1016/S0143-4179(98)90083-X
   Deadman P., 1999, A Manual of Acupuncture
   Deng G, 2008, BMC COMPLEM ALTERN M, V8, DOI 10.1186/1472-6882-8-37
   Deng Liangyue, 2003, Chinese Acupuncture and Moxibustion
   DREIZEN S, 1976, CANCER-AM CANCER SOC, V38, P273, DOI 10.1002/1097-0142(197607)38:1<273::AID-CNCR2820380141>3.0.CO;2-8
   Eisbruch A, 2001, INT J RADIAT ONCOL, V50, P695, DOI 10.1016/S0360-3016(01)01512-7
   Eisbruch A, 1999, INT J RADIAT ONCOL, V45, P577, DOI 10.1016/S0360-3016(99)00247-3
   Eisbruch A, 2003, WORLD J SURG, V27, P832, DOI 10.1007/s00268-003-7105-6
   Braga FDF, 2011, BRAZ ORAL RES, V25, P180
   Garcia MK, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.16910
   Garcia MK, 2015, MED ACUPUNCT, V27, P158, DOI 10.1089/acu.2015.1104
   Hershman DL, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.41720
   Huang LC., 1996, Auriculotherapy, diagnosis and treatment
   Johnstone PAS, 2002, CANCER, V94, P1151, DOI 10.1002/cncr.10348
   Johnstone PAS, 2001, INT J RADIAT ONCOL, V50, P353, DOI 10.1016/S0360-3016(00)01530-3
   Kaptchuk TJ, 2008, BMJ-BRIT MED J, V336, P999, DOI 10.1136/bmj.39524.439618.25
   Lin SC, 2008, J PAIN SYMPTOM MANAG, V36, P141, DOI 10.1016/j.jpainsymman.2007.09.009
   Mao JJ, 2015, J CLIN ONCOL, V33, P3615, DOI 10.1200/JCO.2015.60.9412
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Mao JJ, 2010, ALTERN THER HEALTH M, V16, P22
   Meng ZQ, 2012, EUR J CANCER, V48, P1692, DOI 10.1016/j.ejca.2011.12.030
   Meng ZQ, 2012, CANCER-AM CANCER SOC, V118, P3337, DOI 10.1002/cncr.26550
   Nutting CM, 2011, LANCET ONCOL, V12, P127, DOI 10.1016/S1470-2045(10)70290-4
   Pacholke HD, 2005, AM J CLIN ONCOL-CANC, V28, P351, DOI 10.1097/01.coc.0000158826.88179.75
   Park Jongbae, 2002, Acupunct Med, V20, P168
   Park JJ, 2009, ACUPUNCT MED, V27, P93, DOI 10.1136/aim.2009.001495
   Pfister DG, 2010, J CLIN ONCOL, V28, P2565, DOI 10.1200/JCO.2009.26.9860
   POCOCK SJ, 1975, BIOMETRICS, V31, P103, DOI 10.2307/2529712
   Rydholm M, 1999, J PALLIATIVE CARE, V15, P20, DOI 10.1177/082585979901500404
   Simcock R, 2013, ANN ONCOL, V24, P776, DOI 10.1093/annonc/mds515
   Simcock R, 2009, ACUPUNCT MED, V27, P109, DOI 10.1136/aim.2009.000935
   Sloan JA, 2006, SUPPORT CARE CANCER, V14, P988, DOI 10.1007/s00520-006-0085-y
   Usichenko TI, 2006, ACUPUNCTURE ELECTRO, V31, P213, DOI 10.3727/036012906815844265
   Usichenko TI, 2005, EVID-BASED COMPL ALT, V2, P185, DOI 10.1093/ecam/neh097
   Usichenko TI, 2005, PAIN, V114, P320, DOI 10.1016/j.pain.2004.08.021
NR 50
TC 19
Z9 22
U1 5
U2 16
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD MAY 13
PY 2024
VL 7
IS 5
AR e2410421
DI 10.1001/jamanetworkopen.2024.10421
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RC5U3
UT WOS:001225493300006
PM 38739392
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Mentink, M
   Verbeek, D
   Noordman, J
   Timmer-Bonte, A
   von Rosenstiel, I
   van Dulmen, S
AF Mentink, Marit
   Verbeek, Danielle
   Noordman, Janneke
   Timmer-Bonte, Anja
   von Rosenstiel, Ines
   van Dulmen, Sandra
TI The Effects of Complementary Therapies on Patient-Reported Outcomes: An
   Overview of Recent Systematic Reviews in Oncology
SO CANCERS
LA English
DT Review
DE complementary medicine; oncology; patient-reported outcomes (PROMS);
   overview of systematic reviews; meta-analysis
ID CANCER-RELATED FATIGUE; ALTERNATIVE MEDICINE USE; HEALTH-RELATED
   QUALITY; BREAST-CANCER; INTEGRATIVE MEDICINE; MASSAGE THERAPY;
   METAANALYSIS; INTERVENTIONS; COMMUNICATION; CHEMOTHERAPY
AB Simple Summary Complementary therapies, such as acupuncture, yoga and herbal medicine are used by many patients with cancer to relieve symptoms and side effects from anti-cancer treatment. Clinicians in oncology often lack the knowledge to adequately advise patients about the potential benefits and risks of complementary therapies. This study aims to provide an overview of recently published systematic reviews of the effects of complementary therapies on patient-reported health outcomes in patients with cancer. One hundred systematic reviews were included, and the results suggest that several complementary therapies can improve patient-reported health outcomes in patients with cancer. For instance, acupuncture to relieve pain and yoga to improve cancer-related fatigue. The results remain inconclusive for other complementary therapies. Many included systematic reviews did not assess the impact of bias on their results. Nonetheless, the results from this study can help clinicians to find information about the evidence base for complementary therapies when counselling patients on this topic.Abstract Many patients with cancer make use of complementary medicine alongside conventional medicine, but clinicians in oncology often lack the knowledge to adequately advise patients on the evidence base for complementary therapies. This study aims to provide an overview of recently published systematic reviews that assess the effects of complementary therapies on patient-reported health outcomes in patients with cancer. Systematic reviews, including a meta-analysis of at least two randomized controlled trials, were identified from the PubMed, Embase, Cochrane Library, CINAHL and PsycINFO databases. The methodological quality was assessed with AMSTAR 2. One hundred systematic reviews were included. The results suggest that several complementary therapies can improve health outcomes reported by patients with cancer, such as acupuncture to relieve pain, music interventions to reduce anxiety and yoga to improve cancer-related fatigue. The side effects related to complementary therapy use are generally mild. The results remain inconclusive for some intervention-outcome combinations. Many of the included systematic reviews insufficiently assessed the causes and impact of bias in their interpretation of the results. This overview of systematic reviews can support clinicians in counselling their patients on this topic and provide directions for future research and clinical practice guidelines in the field of complementary medicine.
C1 [Mentink, Marit; Noordman, Janneke; van Dulmen, Sandra] Nivel Netherlands Inst Hlth Serv Res, Otterstr 118, NL-3512 CR Utrecht, Netherlands.
   [Mentink, Marit; van Dulmen, Sandra] Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Dept Primary & Community Care, Med Ctr, Geert Grooteplein Zuid 21, NL-6525 EZ Nijmegen, Netherlands.
   [Verbeek, Danielle] Praktijk Integratieve Oncol, Heesterpoort 18, NL-9713 KZ Groningen, Netherlands.
   [Timmer-Bonte, Anja] Radboud Univ Nijmegen, Med Ctr, Dept Med Oncol, Geert Grooteplein Zuid 10, NL-6525 GA Nijmegen, Netherlands.
   [von Rosenstiel, Ines] Rijnstate Hosp, Dept Integrat Oncol, Wagnerlaan 55, NL-6815 AD Arnhem, Netherlands.
   [van Dulmen, Sandra] Univ Boras, Fac Caring Sci, Work Life & Social Welf, Allegatan 1, S-50190 Boras, Sweden.
C3 Netherlands Institute for Health Services Research; Radboud University
   Nijmegen; Radboud University Nijmegen; Rijnstate Hospital; University of
   Boras
RP Mentink, M (corresponding author), Nivel Netherlands Inst Hlth Serv Res, Otterstr 118, NL-3512 CR Utrecht, Netherlands.; Mentink, M (corresponding author), Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Dept Primary & Community Care, Med Ctr, Geert Grooteplein Zuid 21, NL-6525 EZ Nijmegen, Netherlands.
EM m.mentink@nivel.nl; integratieve.oncologie@gmail.com;
   j.noordman@nivel.nl; anja.timmer-bonte@radboudumc.nl;
   ivonrosenstiel@rijnstate.nl; s.vandulmen@nivel.nl
RI van Dulmen, A.M./L-4287-2015; Timmer-Bonte, J.N.H./L-4692-2015
OI Mentink, Marit/0000-0002-1278-9665; 
FU The authors would like to thank Alice Tillema (A.T.), librarian at
   Radboud University medical center, for her support in establishing the
   search strategy, and Mette van Ginkel (M.v.G.), researcher at Nivel, for
   her help in appraising the methodological qua
FX The authors would like to thank Alice Tillema (A.T.), librarian at
   Radboud University medical center, for her support in establishing the
   search strategy, and Mette van Ginkel (M.v.G.), researcher at Nivel, for
   her help in appraising the methodological quality of the systematic
   reviews.
CR [Anonymous], Dictionary of cancer terms
   Armer JS, 2020, JNCI CANCER SPECT, V4, DOI 10.1093/jncics/pkz098
   Bai X, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/3123878
   Balneaves LG, 2022, JNCI-J NATL CANCER I, V114, P25, DOI 10.1093/jnci/djab048
   Belloni S, 2023, CLIN THER, V45, pE54, DOI 10.1016/j.clinthera.2022.12.001
   Boyd C, 2016, PAIN MED, V17, P1553, DOI 10.1093/pm/pnw100
   Bro ML, 2018, PSYCHO-ONCOLOGY, V27, P386, DOI 10.1002/pon.4470
   Cai Q, 2022, COMPLEMENT THER CLIN, V46, DOI 10.1016/j.ctcp.2021.101510
   Carr PJ, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011429.pub2
   Chan YT, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/9949777
   Chang YC, 2021, CANCER NURS, V44, pE703, DOI 10.1097/NCC.0000000000000889
   Chen CY, 2018, COMPLEMENT MED RES, V25, P406, DOI 10.1159/000491693
   Chen LC, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/8868720
   Chen ST, 2020, J CANCER RES CLIN, V146, P2913, DOI 10.1007/s00432-020-03353-0
   Chen YY, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.629132
   Chen ZQ, 2019, COMPLEMENT THER MED, V47, DOI 10.1016/j.ctim.2019.08.001
   Chien TJ, 2020, CLIMACTERIC, V23, P130, DOI 10.1080/13697137.2019.1664460
   Chien TJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419886662
   Cohen MH, 2002, ANN INTERN MED, V136, P596, DOI 10.7326/0003-4819-136-8-200204160-00009
   Coutiño-Escamilla L, 2019, BREAST, V44, P135, DOI 10.1016/j.breast.2019.01.006
   da Silva FP, 2019, J MANIP PHYSIOL THER, V42, P503, DOI 10.1016/j.jmpt.2018.12.007
   Dai L, 2021, J PALLIAT MED, V24, P1078, DOI 10.1089/jpm.2020.0405
   Danon N, 2022, PSYCHO-ONCOLOGY, V31, P345, DOI 10.1002/pon.5821
   Davis EL, 2012, ONCOLOGIST, V17, P1475, DOI 10.1634/theoncologist.2012-0223
   Deng B, 2018, PHYTOTHER RES, V32, P1211, DOI 10.1002/ptr.6068
   Deng GE, 2013, CHEST, V143, pE420, DOI 10.1378/chest.12-2364
   Dong B, 2021, BMC COMPLEMENT MED, V21, DOI 10.1186/s12906-020-03193-y
   Dong B, 2019, BREAST CANCER RES TR, V177, P5, DOI 10.1007/s10549-019-05278-w
   El-Hashimi D, 2019, J EVID-BASED INTEGR, V24, DOI 10.1177/2515690X19828325
   Foley H, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-38279-8
   Gao Y, 2021, INTEGR CANCER THER, V20, DOI 10.1177/15347354211044107
   Gonzalez M, 2021, PSYCHO-ONCOLOGY, V30, P1196, DOI 10.1002/pon.5671
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Haussmann A, 2022, CANCERS, V14, DOI 10.3390/cancers14082016
   He J, 2020, J NATL MED ASSOC, V112, P387, DOI 10.1016/j.jnma.2020.04.006
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Hou XB, 2020, TMR INTEGR MED, V4, pe20019, DOI [10.53388/tmrim202004019, 10.53388/TMRIM202004019, DOI 10.53388/TMRIM202004019]
   Hsieh SH, 2021, CANCER NURS, V44, pE578, DOI 10.1097/NCC.0000000000000997
   Hsueh EJ, 2021, BREAST CANCER-TOKYO, V28, P264, DOI 10.1007/s12282-020-01209-6
   Hu JQ, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.828450
   Huang ZK, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/2456873
   Huebner J, 2014, BREAST CARE, V9, P60, DOI 10.1159/000360381
   Jang A, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420949679
   Jang S, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021820
   Jin H, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000027163
   Jin YX, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8875433
   Jing XM, 2018, COMPLEMENT THER CLIN, V31, P282, DOI 10.1016/j.ctcp.2018.03.005
   Kabat-Zin Jon., 1990, FULL CATASTROPHE LIV
   Kannan P, 2022, QUAL LIFE RES, V31, P951, DOI 10.1007/s11136-021-02926-x
   Keene MR, 2019, COMPLEMENT THER CLIN, V35, P33, DOI 10.1016/j.ctcp.2019.01.004
   Kemppainen LM, 2018, SCAND J PUBLIC HEALT, V46, P448, DOI 10.1177/1403494817733869
   Kim D, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03614-0
   King N, 2015, INTEGR CANCER THER, V14, P515, DOI 10.1177/1534735415589984
   Kuo CC, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/6651238
   Kwon CY, 2021, PHYTOTHER RES, V35, P751, DOI 10.1002/ptr.6860
   Lee SM, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419890029
   Lee SH, 2015, INTEGR CANCER THER, V14, P297, DOI 10.1177/1534735415572885
   Li DH, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5558590
   Li HJ, 2021, J ALTERN COMPLEM MED, V27, P1084, DOI 10.1089/acm.2021.0133
   Li L, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.661925
   Li ML, 2019, BMC COMPLEM ALTERN M, V19, DOI 10.1186/s12906-019-2441-8
   Li S, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.599073
   Li YF, 2020, J ADV NURS, V76, P1111, DOI 10.1111/jan.14313
   Li YC, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00132
   Li ZY, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/1029626
   Lin LY, 2022, J CLIN PSYCHOL MED S, V29, P432, DOI 10.1007/s10880-022-09862-z
   Lin WF, 2019, CANCER MANAG RES, V11, P6663, DOI 10.2147/CMAR.S195935
   Lin Y, 2022, CLIN BREAST CANCER, V22, pE664, DOI 10.1016/j.clbc.2022.01.013
   Liu C, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/9980940
   Liu J, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/4243175
   Liu LZ, 2020, COMPLEMENT THER CLIN, V38, DOI 10.1016/j.ctcp.2019.101078
   Liu XM, 2021, INTEGR CANCER THER, V20, DOI 10.1177/1534735420980811
   Liu YH, 2018, INTEGR CANCER THER, V18, DOI 10.1177/1534735418817833
   Lu Y, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.698371
   Luo XC, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.00607
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Ma HL, 2019, EUR J INTEGR MED, V30, DOI 10.1016/j.eujim.2019.100960
   Mai QL, 2022, EUR J INTEGR MED, V51, DOI 10.1016/j.eujim.2022.102120
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mazzocco K, 2023, CANCERS, V15, DOI 10.3390/cancers15041176
   Medicine N.L.o, Medical Subject Headings (MeSH)
   Mentink M, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-053005
   Ni XS, 2019, SUPPORT CARE CANCER, V27, P3701, DOI 10.1007/s00520-019-04911-0
   Ni XX, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420980825
   O'Neill M, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420959882
   Qi YS, 2021, SUPPORT CARE CANCER, V29, P3461, DOI 10.1007/s00520-021-05986-4
   Qiao J, 2023, CANCER NURS, V46, P159, DOI 10.1097/NCC.0000000000001061
   Roter DL, 2016, PATIENT EDUC COUNS, V99, P1519, DOI 10.1016/j.pec.2016.06.002
   Schell LK, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011518.pub2
   She YQ, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.714287
   Shea BJ, 2017, BMJ-BRIT MED J, V358, DOI 10.1136/bmj.j4008
   Shi G, 2021, GLAND SURG, V10, P1744, DOI 10.21037/gs-21-284
   Sinha MK, 2021, INDIAN J PALLIAT CAR, V27, P336, DOI 10.25259/IJPC_136_21
   Song JH, 2021, ONCOL NURS FORUM, V48, P207, DOI 10.1188/21.ONF.207-228
   Song SJ, 2018, SUPPORT CARE CANCER, V26, P2091, DOI 10.1007/s00520-018-4136-y
   Suh HW, 2021, COMPLEMENT THER MED, V57, DOI 10.1016/j.ctim.2021.102667
   Sun H, 2021, CLIN NUTR, V40, P1682, DOI 10.1016/j.clnu.2020.11.032
   Tan JY, 2021, COMPLEMENT THER CLIN, V45, DOI 10.1016/j.ctcp.2021.101490
   Tang MF, 2019, SLEEP MED REV, V47, P1, DOI 10.1016/j.smrv.2019.05.003
   Uslu-Sahan F, 2023, J INTEGR MED-JIM, V21, P377, DOI 10.1016/j.joim.2023.06.003
   Wang LC, 2020, COMPLEMENT THER MED, V52, DOI 10.1016/j.ctim.2020.102472
   Wang RY, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.00730
   Wang R, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.684058
   Wang WL, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02566-4
   Wang XP, 2018, J CANCER RES THER, V14, pS600, DOI 10.4103/0973-1482.183174
   Wang YH, 2021, CHIN J INTEGR MED, V27, P713, DOI 10.1007/s11655-020-3423-x
   Wang YX, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/3996101
   Wu JM, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/5015824
   Xie CY, 2020, J PSYCHOSOM RES, V130, DOI 10.1016/j.jpsychores.2019.109916
   Xu GX, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/7858252
   Xunlin NG, 2020, SUPPORT CARE CANCER, V28, P1563, DOI 10.1007/s00520-019-05219-9
   Yang JN, 2020, SUPPORT CARE CANCER, V28, P3571, DOI 10.1007/s00520-020-05433-w
   Yang T, 2021, COMPLEMENT THER CLIN, V44, DOI 10.1016/j.ctcp.2021.101416
   Yangöz ST, 2019, J ADV NURS, V75, P3362, DOI 10.1111/jan.14184
   Yao ZQ, 2022, COMPLEMENT THER CLIN, V46, DOI 10.1016/j.ctcp.2021.101527
   Yi LJ, 2021, ANN PALLIAT MED, V10, P1961, DOI 10.21037/apm-20-1484
   Yin JC, 2020, MENT HEALTH PHYS ACT, V19, DOI 10.1016/j.mhpa.2020.100347
   Yoon JH, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.753140
   Pan YQ, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420940394
   Zeng J, 2022, GLAND SURG, V11, P588, DOI 10.21037/gs-22-114
   Zeng YC, 2020, INT J NURS STUD, V104, DOI 10.1016/j.ijnurstu.2019.103514
   Zhang HW, 2018, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD010559.pub2, 10.1002/14651858.C.D010559.pub2]
   Zhang XW, 2018, AM J CHINESE MED, V46, P923, DOI [10.1142/S0192415X18500490, 10.1142/s0192415x18500490]
   Zhang Y, 2018, SUPPORT CARE CANCER, V26, P415, DOI 10.1007/s00520-017-3955-6
   Zhang YZ, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.646315
   Zhao YY, 2020, J TRADIT CHIN MED, V40, P738, DOI 10.19852/j.cnki.jtcm.2020.05.003
   Zhu XY, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.745280
NR 127
TC 7
Z9 9
U1 1
U2 39
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD SEP
PY 2023
VL 15
IS 18
AR 4513
DI 10.3390/cancers15184513
PG 21
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA S4ZI3
UT WOS:001071261000001
PM 37760483
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Birch, S
   Bovey, M
   Alraek, T
   Robinson, N
   Kim, TH
   Lee, MS
AF Birch, Stephen
   Bovey, Mark
   Alraek, Terje
   Robinson, Nicola
   Kim, Tae-Hun
   Lee, Myeong Soo
TI Acupuncture as a Treatment Within Integrative Health for Palliative
   Care: A Brief Narrative Review of Evidence and Recommendations
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review
DE acupuncture; palliative care; evidence; recommendations
ID COMPLEX INTERVENTIONS; ALTERNATIVE MEDICINE; SYMPTOM MANAGEMENT; SAFETY;
   COMPLEMENTARY; THERAPIES; ONCOLOGY; EFFICACY; DYSPNEA; PAIN
AB Background:Acupuncture is one of the fastest developing evidence bases in Complementary Medicine and is one of the leading therapies included within integrative health care. This narrative review includes two separate parts: the first is about evaluation of the current evidence status in reviews on acupuncture and the second examines and gives examples of available recommendations on acupuncture in treatment guidelines from health care experts and public health organizations recommending acupuncture as a viable treatment in patients in palliative care. Methods:Electronic searches were performed in PubMed using the terms "acupuncture" + "palliative" and adding the term "safety" to find review articles documenting safety and evidence of effectiveness of acupuncture for treatment of symptoms in palliative care patients. Treatment guidelines that recommend use of acupuncture for symptom control in palliative care were found by searching through a database currently under construction by the lead author. Results:Acupuncture shows emerging evidence for 17 indications in palliative care. Examples were found and presented of publications recommending acupuncture for treatment of symptoms for patients in palliative care from Government, public health, oncology, and medical expert sources. The most publications are in oncology, but other conditions were found and a number were found in pediatric care. Conclusions:While the evidence for use of acupuncture to treat symptoms in palliative care patients is relatively weak, the evidence base is growing. Experts worldwide are also increasingly recommending acupuncture as a treatment for symptoms in palliative care. Since acupuncture is a safe, nonpharmacological treatment but with small, clinically significant effects, these recommended uses appear as pragmatic efforts to bridge the gap of treatment options available to this patient group.
C1 [Birch, Stephen; Alraek, Terje] Kristiania Univ Coll, Sch Hlth Sci, N-0152 Oslo, Norway.
   [Bovey, Mark] British Acupuncture Council, Acupuncture Res Resource Ctr, London, England.
   [Alraek, Terje] UiT Arctic Univ Norway, Natl Res Ctr Complementary & Alternat Med, Fac Med, Dept Community Med, Tromso, Norway.
   [Robinson, Nicola] Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing, Peoples R China.
   [Kim, Tae-Hun] Kyung Hee Univ, Korean Med Hosp, Korean Med Clin Trial Ctr, Seoul, South Korea.
   [Lee, Myeong Soo] Korea Inst Oriental Med, Div Clin Med, Daejeon, South Korea.
C3 Kristiania University College; UiT The Arctic University of Tromso;
   Beijing University of Chinese Medicine; Kyung Hee University; Kyung Hee
   University Hospital; Korea Institute of Oriental Medicine (KIOM)
RP Birch, S (corresponding author), Kristiania Univ Coll, Sch Hlth Sci, N-0152 Oslo, Norway.
EM sjbirch@gmail.com
RI Alræk, Terje/AAG-7001-2021; Lee, Myeong Soo/C-8147-2013; Kim,
   Tae-Hun/G-8728-2014
OI Robinson, Nicola/0000-0001-5256-4527; 
CR Adams D, 2011, PEDIATRICS, V128, pE1575, DOI 10.1542/peds.2011-1091
   Adler SR, 2019, J ALTERN COMPLEM MED, V25, P257, DOI 10.1089/acm.2019.29063.sra
   Anderson MD, 2007, PATIENT FAMILY SYMPT
   [Anonymous], 2014, The Palliative Care Handbook, V8A
   [Anonymous], 2016, RESP SYMPT PALL CAR
   [Anonymous], 2016, PAIN MAN PALL CAR
   [Anonymous], [No title captured], DOI DOI 10.1177/1049909108322292
   [Anonymous], Cost-effective commissioning of end -of -life care user guide for the end -of -life economic analysis tool
   Appleyard I, 2014, EUR J INTEGR MED, V6, P234, DOI 10.1016/j.eujim.2014.03.004
   Arbeitsgemeinschaft Gynakologische Onkologie, 2015, DIAGN TREATM PAT PRI
   Australian Government Department of Health and Ageing, GUID PALL APPR AG CA
   Ben-Aharon I, 2008, J CLIN ONCOL, V26, P2396, DOI 10.1200/JCO.2007.15.5796
   Birch J, 2020, BIOL PHILOS, V35, DOI 10.1007/s10539-019-9712-0
   Birch S, 2004, J ALTERN COMPLEM MED, V10, P468, DOI 10.1089/1075553041323894
   Birch S, 2018, J ALTERN COMPLEM MED, V24, P752, DOI 10.1089/acm.2018.0092
   Birch S, 2019, INTEGR MED RES, V8, P160, DOI 10.1016/j.imr.2019.05.002
   Birch Stephen., 1999, UNDERSTANDING ACUPUN
   Brittner M, 2016, CURR PROB PEDIATR AD, V46, P179, DOI 10.1016/j.cppeds.2015.12.005
   Cancer Council Victoria, 2019, PALL CAR
   Colvin L, 2006, BRIT MED J, V332, P1081, DOI 10.1136/bmj.332.7549.1081
   Cornally N., 2016, Palliative care for the person with dementia guidance document 5: pain assessment and management
   Cracolici F, 2019, OBM INTEGRAT COMPLEM, V4, P12
   Craig Peter, 2008, BMJ, V337, pa1655, DOI 10.1136/bmj.a1655
   Cybularz PA, 2015, MED ACUPUNCT, V27, P224, DOI 10.1089/acu.2015.1099
   Dhingra L, 2015, PAIN MED, V16, pS37, DOI 10.1111/pme.12912
   Dodd M J, 2001, Oncol Nurs Forum, V28, P465
   Dutch Association for Pediatrics, 2013, PALL CAR CHILDR
   Ernst Edzard, 2010, J Pain Symptom Manage, V40, pe3, DOI 10.1016/j.jpainsymman.2010.07.003
   Evans CJ, 2013, MRC GUIDANCE DEV EVA
   EviCore Healthcare, 2019, CLIN GUID AC SERV VE
   Filshie J, 2001, Acupunct Med, V19, P117
   Filshie J, 2011, ACUPUNCT MED, V29, P166, DOI 10.1136/acupmed-2011-010063
   Garcia MK, 2014, CURR ONCOL REP, V16, DOI 10.1007/s11912-014-0418-9
   Grande G, 2011, PALLIATIVE MED, V25, P737, DOI 10.1177/0269216311425641
   Grant SJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735418823266
   Hackett J, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-022835
   Hepgul N, 2019, TXB PALLIATIVE CARE, P1669
   Higginson IJ, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-111
   Integral Cancer Center of the Netherlands, 2015, DYSPN PALL PHAS NAT
   Jansen K, 2018, J PAIN SYMPTOM MANAG, V55, P508, DOI 10.1016/j.jpainsymman.2017.06.010
   Janz S., 2019, ACUPUNCTURE EVIDENCE
   Jindal V, 2008, J PEDIAT HEMATOL ONC, V30, P431, DOI 10.1097/MPH.0b013e318165b2cc
   Kahn ST, 2005, ONCOLOGY-NY, V19, P1827
   Kamal AH, 2012, J PALLIAT MED, V15, P106, DOI 10.1089/jpm.2011.0110
   Kelly Kara M, 2009, Hematology Am Soc Hematol Educ Program, P307, DOI 10.1182/asheducation-2009.1.307
   Kim KH, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009440.pub2
   Lau CHY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002901
   Lian WL, 2014, CHIN J INTEGR MED, V20, P136, DOI 10.1007/s11655-013-1439-1
   Liao GS, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/437948
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Lu WD, 2010, CURR TREAT OPTION ON, V11, P141, DOI 10.1007/s11864-010-0126-0
   Lund Irene, 2006, Acupunct Med, V24, P13
   Lytle C.D., 1993, OVERVIEW ACUPUNCTURE
   Ma Y, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168123
   MacPherson H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093739
   MacPherson H, 2012, J ACUPUNCT MERIDIAN, V5, P141, DOI 10.1016/j.jams.2012.05.001
   Maindet C, 2019, SUPPORT CARE CANCER, V27, P3119, DOI 10.1007/s00520-019-04829-7
   Mansky PJ, 2006, CANCER J, V12, P425, DOI 10.1097/00130404-200609000-00011
   Marchand L, 2014, ANN PALLIAT MED, V3, P160, DOI 10.3978/j.issn.2224-5820.2014.07.01
   McPhail P, 2018, EUR J CANCER CARE, V27, DOI 10.1111/ecc.12802
   Miller KR, 2019, AM J HOSP PALLIAT ME, V36, P326, DOI 10.1177/1049909118804464
   Moretto EN, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008768.pub2
   Morrison RS, 2013, CURR OPIN SUPPORT PA, V7, P201, DOI 10.1097/SPC.0b013e32836103e5
   Muecke R, 2016, INTEGR CANCER THER, V15, P10, DOI 10.1177/1534735415596423
   Multiple Sclerosis Society, 2006, MS PALL CAR GUID HLT
   National Cancer Institute, 2019, AC PDQ HLTH PROF VER
   National Comprehensive Cancer Network, 2017, PALL CAR VERS 1 2017
   Norval DA, 2006, CLIN GUIDE SUPPORT 2, P43
   Oneschuk D, 2007, SUPPORT CARE CANCER, V15, P939, DOI 10.1007/s00520-007-0284-1
   Osman Hibah, 2018, J Glob Oncol, V4, P1, DOI 10.1200/JGO.18.00026
   Paley CA, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/neq020
   Pan CX, 2000, J PAIN SYMPTOM MANAG, V20, P374, DOI 10.1016/S0885-3924(00)00190-1
   Pan-Weisz TM, 2019, PSYCHO-ONCOLOGY, V28, P11, DOI 10.1002/pon.4906
   Pediatric Oncology Group of Ontario, 2018, SYMPT MAN GUID CHILD
   Pineda MJ, 2012, OBSTET GYN CLIN N AM, V39, P285, DOI 10.1016/j.ogc.2012.03.001
   Raina R, 2018, HEMODIAL INT, V22, P290, DOI 10.1111/hdi.12622
   Ralston-Wilson J, 2016, J ALTERN COMPLEM MED, V22, P458, DOI 10.1089/acm.2015.0347
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Raphael J, 2010, PAIN MED, V11, P872, DOI 10.1111/j.1526-4637.2010.00841.x
   Ring M, 2017, PRIMARY CARE, V44, P203, DOI 10.1016/j.pop.2017.02.006
   Robinson N, 2019, EUR J INTEGR MED, V32, DOI 10.1016/j.eujim.2019.100997
   Runowicz CD, 2016, CA-CANCER J CLIN, V66, P44, DOI [10.3322/caac.21319, 10.1200/JCO.2015.64.3809]
   Scarborough BM, 2018, CA-CANCER J CLIN, V68, P182, DOI 10.3322/caac.21453
   Scotté F, 2012, ONCOLOGIST, V17, P23, DOI 10.1634/theoncologist.2012-S1-23
   Seamark DA, 2007, J ROY SOC MED, V100, P225, DOI 10.1258/jrsm.100.5.225
   Shafto K, 2018, CHILDREN-BASEL, V5, DOI 10.3390/children5060075
   Standish LJ, 2008, AM J HOSP PALLIAT ME, V25, P298, DOI 10.1177/1049909108315916
   Stussman BJ, 2020, J ALTERN COMPLEM MED, V26, P25, DOI 10.1089/acm.2019.0303
   Thompson LMA, 2019, ASCO POST 2019
   Towler P, 2013, SUPPORT CARE CANCER, V21, P2913, DOI 10.1007/s00520-013-1882-8
   Unschuld PU, 2003, HUANG DI NEI JING SU WEN: NATURE, KNOWLEDGE, IMAGERY IN AN ANCIENT CHINESE MEDICAL TEXT, P1, DOI 10.1525/california/9780520233225.001.0001
   Venkatasalu MR, 2020, BMC ORAL HEALTH, V20, DOI 10.1186/s12903-020-01075-w
   Vesel T, 2011, HANDBOOK OF PEDIATRIC CHRONIC PAIN: CURRENT SCIENCE AND INTEGRATIVE PRACTICE, P193, DOI 10.1007/978-1-4419-0350-1_12
   Vickers A, 2002, QUAL SAF HEALTH CARE, V11, P92, DOI 10.1136/qhc.11.1.92
   Vilela VC, 2017, SAO PAULO MED J, V135, P309, DOI 10.1590/1516-3180.2017.0092060617
   von Trott P, 2020, J PAIN SYMPTOM MANAG, V59, P327, DOI 10.1016/j.jpainsymman.2019.09.007
   Walshe C, 2011, PALLIATIVE MED, V25, P774, DOI 10.1177/0269216311419883
   Watson M, 2016, PALLIATIVE CARE GUID
   Wolff A, 2012, CURR PHARM DESIGN, V18, P5515, DOI 10.2174/138161212803307509
   World Health Organization, 2018, "Integrating Palliative Care and Symptom Relief Into Responses to Humanitarian Emergencies and Crises: a WHO Guide,"
   World Health Organization, 2002, WHO DEF PALL CAR WHO
   World Health Organization, 2006, 3 PALL CAR PEOPL LIV
   Wu XL, 2015, SCI REP-UK, V5, DOI [10.1038/srep11728, 10.1038/srep16776]
   Yang CS, 2015, PEDIATR RES, V78, P112, DOI 10.1038/pr.2015.91
   Yu CF, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419829568
   Zeng YS, 2018, J PAIN SYMPTOM MANAG, V56, P781, DOI 10.1016/j.jpainsymman.2018.07.016
   Zhang CS, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140825
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 108
TC 14
Z9 16
U1 0
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD SEP 1
PY 2020
VL 26
IS 9
BP 784
EP 791
DI 10.1089/acm.2020.0032
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA NN8AD
UT WOS:000569008100008
PM 32924554
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Eskander, JP
   Beakley, BD
   Zhang, S
   Paetzold, J
   Sharma, B
   Kaye, AD
   Sharma, S
AF Eskander, Jonathan P.
   Beakley, Burton D.
   Zhang, Si
   Paetzold, Jacquelyn
   Sharma, Bharat
   Kaye, Alan D.
   Sharma, Sanjay
TI A Multimodal Approach to Pain Management for Patients with Chronic Back
   Pain: Outcome Measures at 1Year
SO CURRENT PAIN AND HEADACHE REPORTS
LA English
DT Review
DE Interdisciplinary pain management; Chronic pain; Low back; Cervical;
   Pain; Interventional; Intervention; Physical therapy; Yoga; Acupuncture;
   Multimodal; Cognitive behavioral therapy; Nutrition
AB Purpose of ReviewThe purpose of this study is to evaluate the effectiveness of a multimodal approach to treating chronic low back pain.Recent FindingsChronic non-cancer-related back pain is often a frustrating and poorly managed problem for patients. It poses a significant public health issue worsened by the widespread use of narcotics. In 2016, the CDC released guidelines with noticeably more strict recommendations on prescription of narcotics for pain.SummaryVeterans at an interventional pain clinic presenting with chronic back pain refractory to medical and to surgical care were enrolled in an 8-week interdisciplinary pain management program. Pain scores were significantly reduced 1year after completion of the program. Patients in this study benefitted from lower and sustained pain scores, a reduction in emergency room, and urgent care clinic visits, as well as generally high satisfaction with the interdisciplinary program.
C1 [Eskander, Jonathan P.] Portsmouth Anesthesia Associates, Dept Anesthesiol, Portsmouth, VA 23703 USA.
   [Beakley, Burton D.] Ocshner Hlth Syst, Dept Anesthesiol, New Orleans, LA USA.
   [Zhang, Si] Stamford Hlth Med Grp, Dept Anesthesiol, Stamford, CT USA.
   [Paetzold, Jacquelyn] STAR Anesthesia PA, Dept Anesthesiol, San Antonio, TX USA.
   [Sharma, Bharat] Duke Univ, Dept Anesthesiol, Durham, NC USA.
   [Kaye, Alan D.] Louisiana State Univ, Dept Anesthesiol, Hlth Sci Ctr, New Orleans, LA USA.
   [Sharma, Sanjay] Southeast Louisiana Vet Hlth Care Syst, Dept Anesthesiol, New Orleans, LA USA.
C3 Duke University; Louisiana State University System; Louisiana State
   University Health Sciences Center New Orleans
RP Eskander, JP (corresponding author), Portsmouth Anesthesia Associates, Dept Anesthesiol, Portsmouth, VA 23703 USA.
EM jeskande@tulane.edu
CR Clark ME, 2003, J REHABIL RES DEV, V40, P381, DOI 10.1682/JRRD.2003.09.0381
   KAMES LD, 1990, PAIN, V41, P41, DOI 10.1016/0304-3959(90)91107-T
   Martin BI, 2008, JAMA-J AM MED ASSOC, V299, P656, DOI 10.1001/jama.299.6.656
   National Research Council (US) and Institute of Medicine (US) Panel on Musculoskeletal Disorders and the Workplace, 2001, MUSC DIS WORKPL LOW
   Sturgeon JA, 2015, PAIN, V156, P2627, DOI 10.1097/j.pain.0000000000000313
NR 5
TC 7
Z9 7
U1 0
U2 20
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1531-3433
EI 1534-3081
J9 CURR PAIN HEADACHE R
JI Curr. Pain Headache Rep.
PD AUG
PY 2019
VL 23
IS 8
AR 54
DI 10.1007/s11916-019-0790-0
PG 4
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA IJ0ST
UT WOS:000475610800002
PM 31286279
DA 2026-01-16
ER

PT J
AU Efverman, A
AF Efverman, Anna
TI A single-item Expectancy Measure's Validity, Reliability, and
   Responsiveness to Detect Changes in Clinical Efficacy Studies of
   Integrative Cancer Therapies: A Methodology Study
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; cancer care; category scale; contextual effects; numeric
   rating scale; nursing; oncology care; rehabilitation; treatment
   expectations; visual analog scale
ID PSYCHOMETRIC PROPERTIES; RATING-SCALES; ACUPUNCTURE; PATIENT; PAIN;
   PLACEBO; COMPLEMENTARY; EXPECTATIONS; METAANALYSIS; DIFFERENCE
AB Background: Expectations may modify outcomes. However, studies often fail to measure expectations. This raises the need for a brief valid and reliable expectancy measure. Objectives: To study treatment expectations in individuals entering acupuncture or rest, validity and test re-test reliability of a single-item expectancy measure graded on a category scale, a Numeric Rating Scale (NRS) and a Visual Analog Scale (VAS), and to identify psychometric differences between the scales. Method: In this methodology study, treatment expectations were measured in 363 participants before they received acupuncture (genuine traditional penetrating or non-penetrating telescopic sham acupuncture, n = 239, 98%, responded) or a control treatment involving just rest (n = 120, 100%, responded), aimed to improve level of relaxation. A treatment expectancy measure, graded on a five-grade category scale, an eight-grade NRS and a 100 mm VAS, was tested for test re-test reliability. Level of expectation and relaxation was measured at baseline, pre- and post-therapy (n = 729 expectancy measurements). Results: The participants scheduled for acupuncture or rest believed moderately (Inter Quartile Range, IQR, moderately-much) and much (IQR moderately-much) the treatment to be effective. The Intra-Class Correlation coefficient versus Kappa coefficient between test and re-test was .868/.868 for the category scale, .820/.820 for the NRS, and .856/.854 for the VAS. The middle step "Believe moderately the treatment to be effective" was equivalent with median 4 (IQR, 3-4) on NRS and median 52 mm (IQR 42-52) on VAS. The response rates were 708 (97%) on the category scale, 707 (97%) on the NRS, and 703 (96%) on the VAS. All three scales discriminated that pre-therapy expectations were more positive in the individuals who reported an improvement in relaxation level (P < .001-.003). The VAS presented higher responsiveness to detect expectancy changes over time (71% increased expectation), compared to the NRS (52% increased) and the category scale (12% increased), P < .001. Conclusions: Individuals entering acupuncture, or a control intervention, presented positive treatment expectations, and the expectancy measure presented satisfactory reliability, validity, high response rates, sensitiveness, and responsiveness. Integrative cancer therapy researchers who want to control for expectancy-related bias in clinical trials should consider measuring expectation using the single-item expectancy measure.
C1 [Efverman, Anna] Univ Gavle, Gavle, Sweden.
C3 University of Gavle
RP Efverman, A (corresponding author), Univ Gavle, Fac Hlth & Occupat Studies, Dept Caring Sci, S-80176 Gavle, Sweden.
EM anna.efverman@hig.se
FX The study thanks all participants, the acupuncture delivering
   therapists, physiotherapists Linnea Oscarsson and Ylva Widgren for their
   contributions in the data collection and data analyzing procedures, and
   statistician Erling Englund for his efforts to the statistical analyses.
CR Bahreini M, 2015, J EMERG MED, V48, P10, DOI 10.1016/j.jemermed.2014.07.039
   Barth J, 2016, J PAIN, V17, P685, DOI 10.1016/j.jpain.2016.01.477
   Burström K, 2001, QUAL LIFE RES, V10, P621, DOI 10.1023/A:1013171831202
   Carrozzino D, 2021, PSYCHOTHER PSYCHOSOM, DOI 10.1159/000516599
   Carter R.E., 2011, REHABILITATION RES P, V4th
   Chae Y, 2017, ACUPUNCT MED, V35, P148, DOI 10.1136/acupmed-2016-011178
   Cheon S, 2018, BMC MED RES METHODOL, V18, DOI 10.1186/s12874-018-0474-1
   de Leon SP, 2004, ARCH MED RES, V35, P157, DOI 10.1016/j.arcmed.2003.07.009
   Dennehy EB, 2002, J ALTERN COMPLEM MED, V8, P421, DOI 10.1089/107555302760253612
   Devilly GJ, 2000, J BEHAV THER EXP PSY, V31, P73, DOI 10.1016/S0005-7916(00)00012-4
   Doehring C, 2016, VET REC, V179, P628, DOI 10.1136/vr.103779
   Ee CC, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186966
   Efverman A, 2020, COMPLEMENT THER MED, V52, DOI 10.1016/j.ctim.2020.102404
   Enblom A, 2012, ANN ONCOL, V23, P1353, DOI 10.1093/annonc/mdr402
   Evers AWM, 2020, PSYCHOTHER PSYCHOSOM, V90, P49, DOI 10.1159/000510738
   Fletcher C, 2018, CANCER TREAT REV, V68, P86, DOI 10.1016/j.ctrv.2018.06.009
   Frisaldi E, 2015, AM J CLIN HYPN, V57, P267, DOI 10.1080/00029157.2014.976785
   Halpern SD, 2003, J CLIN EPIDEMIOL, V56, P109, DOI 10.1016/S0895-4356(02)00598-X
   Hjermstad MJ, 2011, J PAIN SYMPTOM MANAG, V41, P1073, DOI 10.1016/j.jpainsymman.2010.08.016
   Ho E, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-034996
   HORVATH AO, 1989, J COUNS PSYCHOL, V36, P223, DOI 10.1037/0022-0167.36.2.223
   Jamieson S, 2004, MED EDUC, V38, P1217, DOI 10.1111/j.1365-2929.2004.02012.x
   Kirsch I, 2008, PLOS MED, V5, P260, DOI 10.1371/journal.pmed.0050045
   Kong LJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep25325
   Kottner J, 2011, J CLIN EPIDEMIOL, V64, P701, DOI 10.1016/j.jclinepi.2010.12.001
   LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
   Li XT, 2024, INTEGR MED RES, V13, DOI 10.1016/j.imr.2024.101040
   Meissner K, 2013, JAMA INTERN MED, V173, P1941, DOI 10.1001/jamainternmed.2013.10391
   Mokkink LB, 2010, J CLIN EPIDEMIOL, V63, P737, DOI 10.1016/j.jclinepi.2010.02.006
   Mondloch MV, 2001, CAN MED ASSOC J, V165, P174
   Naqvi N, 2006, CURR DIR PSYCHOL SCI, V15, P260, DOI 10.1111/j.1467-8721.2006.00448.x
   Oscarsson L., 2017, Does the Physiotherapists Neutral Versus Positive Communication Modify Individuals Level of Tension After a Treatment Session Including Rest? A Randomized Controlled Experimental Trial
   Owens K, 2015, SOC SCI MED, V128, P18, DOI 10.1016/j.socscimed.2014.12.020
   Pariente J, 2005, NEUROIMAGE, V25, P1161, DOI 10.1016/j.neuroimage.2005.01.016
   Peerdeman KJ, 2016, PAIN, V157, P1179, DOI 10.1097/j.pain.0000000000000540
   Peters ML, 2007, PAIN MED, V8, P601, DOI 10.1111/j.1526-4637.2007.00311.x
   Prady SL, 2015, COMPLEMENT THER MED, V23, P185, DOI 10.1016/j.ctim.2015.01.007
   Smith K, 2016, BIOETHICS, V30, P60, DOI 10.1111/bioe.12243
   Stubbs B, 2016, SPORTS MED, V46, P699, DOI 10.1007/s40279-015-0441-5
   Suarez-Almazor ME, 2010, ARTHRIT CARE RES, V62, P1229, DOI 10.1002/acr.20225
   Svensson E, 2000, STAT MED, V19, P3483, DOI 10.1002/1097-0258(20001230)19:24<3483::AID-SIM786>3.0.CO;2-A
   Tracey T.J., 1989, PSYCHOL ASSESSMENT, V1, P207, DOI DOI 10.1037/1040-3590.1.3.207
   Vincent C., 1990, Complementary Medical Research, V4, P8
   Wampold BE, 2023, WORLD PSYCHIATRY, V22, P25, DOI 10.1002/wps.21035
   Wasan AD, 2006, PAIN MED, V7, P217, DOI 10.1111/j.1526-4637.2006.00154.x
   Widgren Y, 2023, INTEGR CANCER THER, V22, DOI 10.1177/15347354231217296
   Wise RA, 2009, J ALLERGY CLIN IMMUN, V124, P436, DOI 10.1016/j.jaci.2009.05.041
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
   Yang XY, 2022, J INTEGR COMPLEMENT, V28, P202, DOI 10.1089/jicm.2021.0128
   Ylva W, 2022, INTEGR CANCER THER, V21, DOI 10.1177/15347354221077277
   Zisapel N, 2003, J SLEEP RES, V12, P291, DOI 10.1046/j.0962-1105.2003.00365.x
NR 51
TC 3
Z9 3
U1 1
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2024
VL 23
AR 15347354241273944
DI 10.1177/15347354241273944
PG 13
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA D4R6T
UT WOS:001296076400001
PM 39164885
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Frenkel, M
   David, A
   Sapire, K
   Hausner, D
AF Frenkel, Moshe
   David, Adi
   Sapire, Kenneth
   Hausner, David
TI Complementary and Integrative Medicine in Pancreatic Cancer
SO CURRENT ONCOLOGY REPORTS
LA English
DT Review
DE Pancreatic cancer; Pancreatic ductal adenocarcinoma; Complementary
   medicine; Integrative medicine; Touch therapies; Nutrition; Nutritional
   supplements; Physical activity; Acupuncture; Reflexology; Homeopathy;
   Curcumin; Mind-body medicine; Dietary supplements
ID PHYSICAL-ACTIVITY; MICROBIOME; MANAGEMENT; RISK; CHEMOTHERAPY; ONCOLOGY;
   SURVIVAL; AHCC; PAIN
AB Purpose of Review Pancreatic cancer has high mortality and morbidity rates, associated with the issues of typically late diagnosis and the limited effectiveness of current treatments. Patients tend to experience multiple symptoms that can include anxiety, fear, depression, fatigue, weakness, peripheral neuropathy, and abdominal pain, which reduce quality of life (QoL) and may compromise the treatment continuum. Many of those symptoms are amenable to complementary and integrative medicine (CIM) therapies as a part of supportive and palliative care. This article reviews research findings on the beneficial effect of use of CIM modalities in regard to pancreatic cancer, with emphasis on pancreatic ductal adenocarcinoma (PDAC).
   Recent Findings Given the often-poor prognosis of the disease, patients with PDAC often seek integrative therapies to help manage the disease itself, to provide support through cancer treatment and its symptoms, and to provide emotional stress relief. Data is accumulating in the past few years on the potential benefits of CIM to the management of pancreatic cancer symptoms and treatment side effects, in order to augment supportive care. This data reveal that nutrition counselling; digestive enzyme therapy; microbiome support; dietary supplements; lifestyle interventions (physical activity and circadian health/sleep hygiene) appear to improve QoL of these patients through reduced symptom burden and meeting psychological needs, such as distress and fatigue. Acupuncture, mindfulness, yoga, reflexology, massage, and homeopathy may also contribute to symptom reduction, both physical and psychological, in all stages of the disease.
   Summary There is supporting evidence that some CIM modalities may alleviate side effects and symptoms related to pancreatic cancer and its treatment, suggesting that practitioners might consider integrating these modalities in certain situations encountered in the treatment of pancreatic cancer. Further investigation is needed to define the optimal integration of CIM into the treatment and supportive care of patients affected by pancreatic cancer.
C1 [Frenkel, Moshe] Rambam Hlth Care Campus, Complementary & Integrat Med Serv, Oncol Div, H_efa, Israel.
   [David, Adi; Hausner, David] Chaim Sheba Med Ctr, Inst Oncol, Tal Ctr Integrat Med, Ramat Gan, Israel.
   [Sapire, Kenneth] Univ Texas MD Anderson Canc Ctr, Dept Anesthesiol & Perioperat Med, Houston, TX USA.
   [Hausner, David] Chaim Sheba Med Ctr, Palliat Care Serv, Ramat Gan, Israel.
C3 Rambam Health Care Campus; Chaim Sheba Medical Center; Tel Aviv
   University; University of Texas System; UTMD Anderson Cancer Center;
   Chaim Sheba Medical Center; Tel Aviv University
RP Frenkel, M (corresponding author), Rambam Hlth Care Campus, Complementary & Integrat Med Serv, Oncol Div, H_efa, Israel.
EM frenkelm@netvision.net.il
RI David, Adi/LBI-5899-2024; hausner, david/AAW-9363-2020
OI David, Adi/0009-0008-0617-9933; Frenkel, Moshe/0000-0002-0245-0764;
   hausner, david/0009-0008-8623-0347
CR Akce M, 2019, ONCOL HEMATOL REV US, V15, P27
   [Anonymous], 2021, NCCN CLIN PRACTICE G
   [Anonymous], NCCN CLIN PRACTICE G
   Antunes F, 2018, CLINICS, V73, DOI 10.6061/clinics/2018/e814s
   Arshad A, 2017, JPEN-PARENTER ENTER, V41, P398, DOI 10.1177/0148607115595221
   Ba DM, 2021, ADV NUTR, V12, P1691, DOI 10.1093/advances/nmab015
   Barnes AF, 2018, PANCREAS, V47, P1065, DOI 10.1097/MPA.0000000000001148
   Behrens G, 2015, EUR J EPIDEMIOL, V30, P279, DOI 10.1007/s10654-015-0014-9
   Bimonte S, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070433
   Block KI, 2018, J ALTERN COMPLEM MED, V24, P890, DOI 10.1089/acm.2018.0125
   Bonucci M, 2018, INTEGR CANCER THER, V17, P994, DOI 10.1177/1534735418755479
   Bouvard V, 2015, LANCET ONCOL, V16, P1599, DOI 10.1016/S1470-2045(15)00444-1
   Brennan GT, 2019, J PANCREAS, V20, P126
   Cereda E, 2019, CANCER MED-US, V8, P6923, DOI 10.1002/cam4.2517
   Chalhoub S., 2021, SLEEP DISORDERS, V4, P1
   Chen H, 2013, PANCREATOLOGY, V13, P594, DOI 10.1016/j.pan.2013.10.007
   Chen SM, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-77322-5
   Collins KP, 2017, SLEEP MED, V32, P208, DOI 10.1016/j.sleep.2016.06.041
   Coveler AL, 2021, ONCOLOGIST, V26, pE971, DOI 10.1002/onco.13796
   D'Orta A, 2018, WORLD CANCER RES J, V5
   David A, 2021, CURR ONCOL REP, V23, DOI 10.1007/s11912-021-01135-6
   Di Marco Mariacristina, 2018, Acta Biomed, V89, P18, DOI 10.23750/abm.v89i4-S.7063
   Djalilova DM, 2019, BIOL RES NURS, V21, P198, DOI 10.1177/1099800418820162
   Ducreux M, 2015, ANN ONCOL, V26, pV56, DOI 10.1093/annonc/mdv295
   Eliaz I, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112619
   Epelbaum R, 2010, NUTR CANCER, V62, P1137, DOI 10.1080/01635581.2010.513802
   Falkensteiner Maria, 2011, ISRN Nurs, V2011, P929868, DOI 10.5402/2011/929868
   Focan C, 2015, ANTICANCER RES, V35, P6311
   Frenkel M, 2022, CURR ONCOL REP, V24, P1557, DOI 10.1007/s11912-022-01308-x
   Frenkel M, 2015, CURR ONCOL REP, V17, DOI 10.1007/s11912-015-0467-8
   Gaertner K, 2014, COMPLEMENT THER MED, V22, P320, DOI 10.1016/j.ctim.2013.12.014
   Gaertner S, 2015, GASTROINTEST TUMORS, V2, P195, DOI 10.1159/000442873
   García-Costela M, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00638
   Gidron Y, 2018, J CLIN MED, V7, DOI 10.3390/jcm7100371
   Giordano A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102376
   González A, 2021, CANCERS, V13, DOI 10.3390/cancers13133263
   Gumbs AA, 2021, SURGERIES-BASEL, V2, P216, DOI 10.3390/surgeries2020022
   Hashimoto D, 2021, SURG TODAY, V51, P1872, DOI 10.1007/s00595-021-02308-3
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Huang XY, 2016, SCI REP-UK, V6, DOI 10.1038/srep38936
   Isherwood J, 2020, ANN TRANSL MED, V8, DOI 10.21037/atm.2020.02.02
   Jemal A, 2007, CA-CANCER J CLIN, V57, P43, DOI 10.3322/canjclin.57.1.43
   Jentzsch V, 2020, CANCERS, V12, DOI 10.3390/cancers12113096
   Kanai M, 2011, CANCER CHEMOTH PHARM, V68, P157, DOI 10.1007/s00280-010-1470-2
   Kazmierczak-Siedlecka K, 2021, EUR REV MED PHARMACO, V25, P7275, DOI 10.26355/eurrev_202112_27421
   Kita A, 2020, INT J ONCOL, V57, P721, DOI 10.3892/ijo.2020.5096
   Kleeff J, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.22
   Kobayashi T, 2011, CLIN EXP METASTAS, V28, P367, DOI 10.1007/s10585-011-9376-x
   Landers Amanda, 2019, Palliat Care, V12, p1178224218825270, DOI [10.1177/1178224218825270, 10.1177/1178224218825270]
   Lewis AR, 2018, CURR PROB CANCER, V42, P26, DOI 10.1016/j.currproblcancer.2018.01.013
   Li LY, 2015, WORLD J SURG ONCOL, V13, DOI 10.1186/s12957-015-0454-4
   Lissoni P, 2008, ANTICANCER RES, V28, P1377
   Liu Y, 2018, MEDICINE, V97, DOI [10.1097/MD.0000000000010114, 10.1097/md.0000000000010114]
   Lu PY, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010038
   Luo H, 2021, PANCREAS, V50, P280, DOI 10.1097/MPA.0000000000001753
   Ma YJ, 2015, NUTR CANCER, V67, P112, DOI 10.1080/01635581.2015.976315
   Mach Claire M, 2008, J Soc Integr Oncol, V6, P105
   Mansouri K, 2020, BMC CANCER, V20, DOI 10.1186/s12885-020-07256-8
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Matsushita Y, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2385-4
   McQuade JL, 2019, LANCET ONCOL, V20, pE77, DOI 10.1016/S1470-2045(18)30952-5
   Mitchell T, 2019, HEALTHCARE-BASEL, V7, DOI 10.3390/healthcare7030089
   Moffat GT, 2019, CANCER-AM CANCER SOC, V125, P3927, DOI 10.1002/cncr.32423
   Molina-Montes E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072010
   Nangia-Makker P, 2018, GLYCOBIOLOGY, V28, P172, DOI 10.1093/glycob/cwy001
   National Comprehensive Cancer Network, 2022, NCCN GUID SUPP CAR
   Pedrosa LD, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12020289
   Pezzilli R, 2020, CANCERS, V12, DOI 10.3390/cancers12020275
   Pushalkar S, 2018, CANCER DISCOV, V8, P403, DOI 10.1158/2159-8290.CD-17-1134
   Riquelme E, 2019, CELL, V178, P795, DOI 10.1016/j.cell.2019.07.008
   Samuels N, 2018, INTEGR CANCER THER, V17, P486, DOI 10.1177/1534735417736133
   Sluyter JD, 2021, JBMR PLUS, V5, DOI 10.1002/jbm4.10420
   Sobocki BK, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124425
   Song SM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042699
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Talib WH, 2021, MOLECULES, V26, DOI 10.3390/molecules26092506
   Tyagi Anupama, 2016, Int J Yoga, V9, P97, DOI [10.4103/0973-6131.183712, 10.4103/0973-6131.183712]
   Védie AL, 2019, PRESSE MED, V48, pE175, DOI 10.1016/j.lpm.2019.02.032
   Venturella G, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22020634
   Vujasinovic M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030183
   Wang Z, 2014, DIABETES RES CLIN PR, V106, P19, DOI 10.1016/j.diabres.2014.04.007
   Wei DY, 2021, CANCERS, V13, DOI 10.3390/cancers13112716
   World Cancer Research Fund/American Institute for Cancer Research, Continuous Update Project Expert Report 2018. Diet, nutrition, physical activity and colorectal cancer
   Xiao Q, 2021, CANCER RES, V81, P1616, DOI 10.1158/0008-5472.CAN-20-2256
   Xie FF, 2021, J SPORT HEALTH SCI, V10, P4, DOI 10.1016/j.jshs.2020.09.009
   Yanagimoto H, 2016, NUTR CANCER, V68, P234, DOI 10.1080/01635581.2016.1134597
   Zhang M, 2019, PROG MOL BIOL TRANSL, V163, P297, DOI 10.1016/bs.pmbts.2019.02.013
   Zhang ZQ, 2020, CANCER MED-US, V9, P6843, DOI 10.1002/cam4.3348
   Zhou DC, 2017, ONCOTARGET, V8, P62349, DOI 10.18632/oncotarget.17728
   Zoi V, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9091086
NR 90
TC 8
Z9 12
U1 1
U2 17
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3790
EI 1534-6269
J9 CURR ONCOL REP
JI Curr. Oncol. Rep.
PD MAR
PY 2023
VL 25
IS 3
BP 231
EP 242
DI 10.1007/s11912-023-01370-z
EA FEB 2023
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 8Y4IV
UT WOS:000923574200001
PM 36735141
DA 2026-01-16
ER

PT J
AU Ribeiro, H
   Alves, R
   Jorge, J
   Gonçalves, AC
   Sarmento-Ribeiro, AB
   Teixeira-Veríssimo, M
   Dourado, M
   Andrade, JP
AF Ribeiro, Hugo
   Alves, Raquel
   Jorge, Joana
   Goncalves, Ana Cristina
   Sarmento-Ribeiro, Ana Bela
   Teixeira-Verissimo, Manuel
   Dourado, Marilia
   Andrade, Jose Paulo
TI Platelet Membrane Proteins as Pain Biomarkers in Patients with Severe
   Dementia
SO BIOMEDICINES
LA English
DT Article
DE chronic pain; pharmacology; platelets; biomarkers; palliative care
ID RICH FIBRIN; PERFORMANCE; ACTIVATION; RECEPTORS; CD49F
AB Pain is one of the most frequent health problems, and its evaluation and therapeutic approach largely depend on patient self-report. When it is not possible to obtain a self-report, the therapeutic decision becomes more difficult and limited. This study aims to evaluate whether some membrane platelet proteins could be of value in pain characterization. To achieve this goal, we used 53 blood samples obtained from palliative patients, 44 with non-oncological pain and nine without pain. We observed in patients with pain a decrease in the percentage of platelets expressing CD36, CD49f, and CD61 and in the expression levels of CD49f and CD61 when compared with patients without pain. Besides that, an increase in the percentage of platelets expressing CD62p was observed in patients with pain. These results suggest that the levels of these platelet cluster differentiations (CDs) could have some value as pain biomarkers objectively since they are not dependent on the patient's participation. Likewise, CD40 seems to have some importance as a biomarker of moderate and/or severe pain. The identification of pain biomarkers such as CD40, CD49f, CD62p and CD61 can lead to an adjustment of the therapeutic strategy, contributing to a faster and more adequate control of pain and reduction in patient-associated suffering.
C1 [Ribeiro, Hugo] Grp Hlth Ctr Gaia, Community Support Team Palliat Care, P-4430999 Vila Nova De Gaia, Portugal.
   [Ribeiro, Hugo] Univ Porto, Fac Med, P-4200319 Porto, Portugal.
   [Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Goncalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Teixeira-Verissimo, Manuel; Dourado, Marilia] Univ Coimbra, Fac Med, P-3000548 Coimbra, Portugal.
   [Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Goncalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Dourado, Marilia] Univ Coimbra FMUC, Coimbra Inst Clin & Biomed Res iCBR, Grp Environm Genet & Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.
   [Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Goncalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela] Univ Coimbra FMUC, Univ Clin Hematol & Oncol, Fac Med, P-3000548 Coimbra, Portugal.
   [Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Goncalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela] Univ Coimbra FMUC, Fac Med, Lab Oncobiol & Hematol LOH, P-3000548 Coimbra, Portugal.
   [Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Goncalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Dourado, Marilia] Ctr Innovat Biomed & Biotechnol CIBB, P-3000548 Coimbra, Portugal.
   [Sarmento-Ribeiro, Ana Bela; Teixeira-Verissimo, Manuel] Ctr Hosp & Univ Coimbra CHUC, Hematol Serv, P-3000548 Coimbra, Portugal.
   [Andrade, Jose Paulo] Univ Porto, Fac Med, CINTESIS RISE, P-4200319 Porto, Portugal.
   [Andrade, Jose Paulo] Univ Porto, Fac Med, Dept Biomed, Unit Anat, P-4200319 Porto, Portugal.
C3 Universidade do Porto; Universidade de Coimbra; Universidade de Coimbra;
   Universidade de Coimbra; Universidade de Coimbra; Universidade de
   Coimbra; Universidade de Coimbra; Centro Hospitalar e Universitario de
   Coimbra (CHUC); Universidade do Porto; Universidade do Porto
RP Ribeiro, H (corresponding author), Grp Hlth Ctr Gaia, Community Support Team Palliat Care, P-4430999 Vila Nova De Gaia, Portugal.; Ribeiro, H (corresponding author), Univ Porto, Fac Med, P-4200319 Porto, Portugal.; Ribeiro, H (corresponding author), Univ Coimbra, Fac Med, P-3000548 Coimbra, Portugal.; Ribeiro, H (corresponding author), Univ Coimbra FMUC, Coimbra Inst Clin & Biomed Res iCBR, Grp Environm Genet & Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.; Ribeiro, H (corresponding author), Univ Coimbra FMUC, Univ Clin Hematol & Oncol, Fac Med, P-3000548 Coimbra, Portugal.; Ribeiro, H (corresponding author), Univ Coimbra FMUC, Fac Med, Lab Oncobiol & Hematol LOH, P-3000548 Coimbra, Portugal.; Ribeiro, H (corresponding author), Ctr Innovat Biomed & Biotechnol CIBB, P-3000548 Coimbra, Portugal.
EM hribeiroff@gmail.com
RI Sarmento Ribeiro, Ana Bela/U-9773-2017; Anade, Jose Paulo/L-8036-2013;
   Gonçalves, Ana Cristina/V-2202-2017; Ribeiro, Hugo/KIL-0145-2024;
   Verdasca Jorge, Joana Margarida/F-2454-2019; Alves, Raquel/V-2781-2017;
   Jorge, Joana/F-2454-2019
OI Sarmento Ribeiro, Ana Bela/0000-0002-4142-4841; Anade, Jose
   Paulo/0000-0003-2585-200X; Dourado, Marília/0000-0002-5003-4722;
   Gonçalves, Ana Cristina/0000-0003-1470-4802; Ribeiro,
   Hugo/0000-0001-6623-7420; Verdasca Jorge, Joana
   Margarida/0000-0003-0755-8077; Alves, Raquel/0000-0003-2599-6433; 
FU National Funds through FCT-Fundacao para a Ciencia e a Tecnologia within
   CINTESIS, RD Unit [UIDB/4255/2020]; RISE, Associated Laboratory
   [LA/P/0053/2020]
FX This article was supported by National Funds through FCT-Fundacao para a
   Ciencia e a Tecnologia, I.P., within CINTESIS, R&D Unit (reference
   UIDB/4255/2020) and within the scope of the project RISE, Associated
   Laboratory (reference LA/P/0053/2020).
CR Akingbade OES, 2018, J ALZHEIMERS DIS, V63, P1235, DOI 10.3233/JAD-180181
   Ali A, 2018, CUREUS J MED SCIENCE, V10, DOI 10.7759/cureus.3293
   Altintoprak F, 2013, WORLD J EMERG SURG, V8, DOI 10.1186/1749-7922-8-49
   Antibody Engineering & Therapeutics, HUM P SEL CD62P
   Arman M, 2015, NON-THROMBOTIC ROLE OF PLATELETS IN HEALTH AND DISEASE, P37, DOI 10.5772/60536
   Avcioglu Sumeyra Nergiz, 2014, ISRN Obstet Gynecol, V2014, P713542, DOI 10.1155/2014/713542
   Barbar L, 2020, NEURON, V107, P436, DOI 10.1016/j.neuron.2020.05.014
   Barkai O, 2019, PAIN, V160, P1281, DOI 10.1097/j.pain.0000000000001523
   Beko K, 2017, J THROMB HAEMOST, V15, P1223, DOI 10.1111/jth.13684
   Chen YF, 2020, BIOMARK RES, V8, DOI 10.1186/s40364-020-00207-2
   Chignon-Sicard B, 2012, PLAST RECONSTR SURG, V130, p819E, DOI 10.1097/PRS.0b013e31826d1711
   Dostert C, 2019, PHYSIOL REV, V99, P115, DOI 10.1152/physrev.00045.2017
   Farag M, 2016, HEART, V102, pA19, DOI 10.1136/heartjnl-2016-309890.28
   Garcia-Larrea L, 2013, PAIN, V154, pS29, DOI 10.1016/j.pain.2013.09.001
   Gianazza E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21124541
   Green SA, 2015, AIDS, V29, P1297, DOI 10.1097/QAD.0000000000000701
   Gruba SM, 2021, ACS MEAS SCI AU, V2, P4, DOI 10.1021/acsmeasuresciau.1c00012
   Jankovic S, 2012, INT J PERIODONT REST, V32, P165
   Kopeikina E, 2021, FRONT CELL NEUROSCI, V15, DOI 10.3389/fncel.2021.680126
   Kumar N, 2015, J ORAL MAXIL SURG, V73, P1042, DOI 10.1016/j.joms.2014.11.013
   Kwon YJ, 2020, THER ADV MUSCULOSKEL, V12, DOI 10.1177/1759720X20912861
   Levi M, 2009, BRIT J HAEMATOL, V145, P24, DOI [10.1111/j.1365-2141.2009.07600.x, 10.1111/j.1365-2141.2008.07445.x]
   Ludwig N, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11121957
   Marchi A, 2009, CLIN DRUG INVEST, V29, P41, DOI 10.2165/0044011-200929001-00006
   Michels WM, 2010, CLIN J AM SOC NEPHRO, V5, P1003, DOI 10.2215/CJN.06870909
   MOR V, 1984, CANCER-AM CANCER SOC, V53, P2002, DOI 10.1002/1097-0142(19840501)53:9<2002::AID-CNCR2820530933>3.0.CO;2-W
   Niculescu AB, 2019, MOL PSYCHIATR, V24, P501, DOI 10.1038/s41380-018-0345-5
   Orr PM, 2017, CRIT CARE NURS CLIN, V29, P407, DOI 10.1016/j.cnc.2017.08.002
   Osman Y, 2018, J HEMATOP, V11, P37, DOI 10.1007/s12308-018-0322-6
   Ozgul O, 2015, HEAD FACE MED, V11, DOI 10.1186/s13005-015-0094-5
   Raja SN, 2020, PAIN, V161, P1976, DOI 10.1097/j.pain.0000000000001939
   Ramos-Cejudo J, 2022, J AM HEART ASSOC, V11, DOI 10.1161/JAHA.121.023918
   RECHES A, 1980, NATURE, V288, P382, DOI 10.1038/288382a0
   Ribatti D, 2007, LEUKEMIA RES, V31, P1339, DOI 10.1016/j.leukres.2007.02.008
   Ribeiro H.A.C. da., 2017, Particularidades da avaliacao e tratamento da dor no idoso: contributo para a validacao da Pain Quality Assessment Scale e abordagem terapeutica na populacao idosa
   RINGKAMP M, 1994, NEUROSCI LETT, V170, P103, DOI 10.1016/0304-3940(94)90249-6
   Rodriguez C S, 2001, Pain Manag Nurs, V2, P38, DOI 10.1053/jpmn.2001.23746
   Saboor M, 2013, PAK J MED SCI, V29, P891, DOI 10.12669/pjms.293.3497
   SALEM HH, 1980, JAMA-J AM MED ASSOC, V244, P1122
   Schedel A, 2010, TRANSFUS MED HEMOTH, V37, P293, DOI 10.1159/000319841
   Sevush S, 1998, ARCH NEUROL-CHICAGO, V55, P530, DOI 10.1001/archneur.55.4.530
   Silverstein RL, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.272re3
   Soysal P, 2019, J AM MED DIR ASSOC, V20, P183, DOI 10.1016/j.jamda.2018.07.016
   Steel HC, 2021, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.594110
   Valkonen S, 2019, TRANSFUS MED HEMOTH, V46, P267, DOI 10.1159/000499958
   Warden Victoria, 2003, J Am Med Dir Assoc, V4, P9, DOI 10.1016/S1525-8610(04)70258-3
   Weinstock Christof, 2015, Immunohematology, V31, P145, DOI 10.21307/immunohematology-2019-083
   Weth D, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00140
   World Health Organization, 2007, NORM GUID PAIN MAN
   World Health Organization, 2009, WHOS PAIN REL LADD
   Yang ZG, 2015, STEM CELLS, V33, P2798, DOI 10.1002/stem.2063
NR 51
TC 3
Z9 3
U1 0
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD FEB
PY 2023
VL 11
IS 2
AR 380
DI 10.3390/biomedicines11020380
PG 12
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 9H6QK
UT WOS:000938955000001
PM 36830917
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Stoerkel, E
   Bellanti, D
   Paat, C
   Peacock, K
   Aden, J
   Setlik, R
   Walter, J
   Inman, A
AF Stoerkel, Erika
   Bellanti, Dawn
   Paat, Charmagne
   Peacock, Kimberly
   Aden, James
   Setlik, Robert
   Walter, Joan
   Inman, Alice
TI Effectiveness of a Self-Care Toolkit for Surgical Breast Cancer Patients
   in a Military Treatment Facility
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE self-care; mind-body skills; breast cancer; surgery; pain; anxiety
ID QUALITY-OF-LIFE; STRESS REDUCTION; MINDFULNESS; INTERVENTION;
   RELAXATION; INFLAMMATION; THERAPIES; SYMPTOMS; DISTRESS; PROGRAM
AB Objective: To assess whether a self-care toolkit (SCT) provided to breast cancer patients undergoing surgery could mitigate distress and lessen symptoms associated with surgery. Design: One hundred women with breast cancer, planning to undergo initial surgery, were randomly assigned to either one of two groups: treatment as usual (TAU; n=49) or TAU with the addition of an SCT (n=51). The SCT contained an MP3 player with audio-files of guided mind-body techniques (breathing, progressive muscle relaxation, meditation, guided imagery, and self-hypnosis) and acupressure antinausea wristbands. Anxiety, pain, nausea, sleep, fatigue, global health, and quality of life (QOL) were assessed using validated outcome measures. Two inflammatory blood markers (erythrocyte sedimentation rate [ESR] and C-reactive protein [CRP]) were measured serially. Data were collected at baseline (T1), immediately before surgery (T2), within 10h postoperatively (T3), and approximate to 2 weeks postsurgery (T4). Settings: Numerous studies have shown that psychological distress associated with a cancer diagnosis can affect pain perception and QOL. Results: Between T1 and T4, there were significant between-group differences in Patient-Reported Outcomes Measurement Information System (PROMIS)-57 scores of Pain Interference, Fatigue, and Satisfaction with Social Roles, favoring the SCT group compared with TAU (p=0.005, p=0.023, and p=0.021, respectively). There was a significant mean change in Defense and Veterans Pain Rating Scale (DVPRS) scores from T2 to T3, with the SCT group having significantly smaller increases in postoperative pain (p=0.008) and in postoperative ESR (p=0.0197) compared with the TAU group. Clinically significant reductions in anxiety occurred in the SCT group during the main intervention period. Conclusion: These results suggest that using the SCT in the perioperative period decreased pain perceptions, fatigue, and inflammatory cytokine secretion.
C1 [Stoerkel, Erika; Bellanti, Dawn; Paat, Charmagne] Thought Leadership & Innovat Fdn, 1750 Tysons Blvd,Suite 1500, Mclean, VA 22102 USA.
   [Peacock, Kimberly] Univ Texas Hlth San Antonio, Dept Epidemiol & Biostat, San Antonio, TX USA.
   [Aden, James; Setlik, Robert; Inman, Alice] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
   [Walter, Joan] Samueli Inst, Alexandria, VA USA.
C3 University of Texas System; University of Texas at San Antonio; United
   States Department of Defense; United States Army; Brooke Army Medical
   Center
RP Stoerkel, E (corresponding author), Thought Leadership & Innovat Fdn, 1750 Tysons Blvd,Suite 1500, Mclean, VA 22102 USA.
EM erika.l.stoerkel@gmail.com
OI Bellanti, Dawn/0000-0003-4507-2625
FU U.S. Army Medical Research and Materiel Command [W81XWH-11-1-0538]; U.S.
   Army Medical Research Acquisition Activity,Chandler Street, Fort Detrick
   MD
FX The authors acknowledge the following individuals for their
   contributions: Ms. Katherine Smith (codeveloper of SCT), Dr. Salvatore
   Libretto (protocol writing, study Principal Investigator), Dr. Karin
   Nicholson (onsite Principal Investigator), Dr. Bonnie Sakallaris and Ms.
   Sita Ananth (SCT project initiation), Mrs. Sandra Jarzombek
   (recruitment, data collection), Ms. Bianca Rodriguez (recruitment, data
   collection), Ms. Susan Ferrise (recruitment, data collection), Mrs. Edna
   Figuordias (recruitment, data collection), Ms. Ames Davis (recruitment,
   data collection), Ms. Ashley Price (protocol writing, project
   management), Dr. Shawnn Nichols (Associate Investigator), Dr. Peter
   Learn (Associate Investigator), and Dr. Christy Chai (Associate
   Investigator). This project was sponsored by the U. S. Army Medical
   Research and Materiel Command under Award Number W81XWH-11-1-0538. The
   U.S. Army Medical Research Acquisition Activity, 820 Chandler Street,
   Fort Detrick MD 21702-5014 is the awarding and administering acquisition
   office. The view(s) expressed herein are those of the author(s) and do
   not reflect the official policy or position of BAMC, the U. S. Army
   Medical Department, the U.S. Army Office of the Surgeon General, the
   Department of the Air Force, the Department of the Army or the
   Department of Defense or the U. S. Government.
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Boyapati L, 2007, PERIODONTOL 2000, V44, P195, DOI 10.1111/j.1600-0757.2007.00211.x
   Bränström R, 2010, ANN BEHAV MED, V39, P151, DOI 10.1007/s12160-010-9168-6
   BRIDGE LR, 1988, BMJ-BRIT MED J, V297, P1169, DOI 10.1136/bmj.297.6657.1169
   Buckenmaier CC, 2013, PAIN MED, V14, P110, DOI 10.1111/j.1526-4637.2012.01516.x
   Carlson LE, 2004, BRIT J CANCER, V90, P2297, DOI 10.1038/sj.bjc.6601887
   Carlson LE, 2003, PSYCHOSOM MED, V65, P571, DOI 10.1097/01.PSY.0000074003.35911.41
   Chan CWH, 2011, J PAIN SYMPTOM MANAG, V41, P347, DOI 10.1016/j.jpainsymman.2010.04.024
   Crawford C, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/747694
   DECKER TW, 1992, J CLIN PSYCHOL, V48, P388, DOI 10.1002/1097-4679(199205)48:3<388::AID-JCLP2270480318>3.0.CO;2-O
   Fawzy NW, 1995, CANCER NURS, V18, P427
   Gabay C, 1999, NEW ENGL J MED, V340, P448, DOI 10.1056/NEJM199902113400607
   Greenlee Heather, 2014, Journal of the National Cancer Institute Monographs, P346, DOI 10.1093/jncimonographs/lgu041
   Hofmann SG, 2010, J CONSULT CLIN PSYCH, V78, P169, DOI 10.1037/a0018555
   Izawa S, 2013, BRAIN BEHAV IMMUN, V27, P38, DOI 10.1016/j.bbi.2012.07.001
   Jensen RE, 2017, J CLIN ONCOL, V35, P1913, DOI 10.1200/JCO.2016.71.4410
   Johnston Marie, 1993, Annals of Behavioral Medicine, V15, P245
   Kabat-Zinn J., 1999, Mindfulness-based stress reduction professional training resource manual
   Kaliman P, 2014, PSYCHONEUROENDOCRINO, V40, P96, DOI 10.1016/j.psyneuen.2013.11.004
   Kyranou M, 2014, CANCER NURS, V37, P406, DOI 10.1097/NCC.0000000000000131
   Lang EV, 2000, LANCET, V355, P1486, DOI 10.1016/S0140-6736(00)02162-0
   Lanting S, 2013, ANN CONV CAN PSYCH A
   Lengacher CA, 2009, PSYCHO-ONCOLOGY, V18, P1261, DOI 10.1002/pon.1529
   Malarkey WB, 2013, BRAIN BEHAV IMMUN, V27, P145, DOI 10.1016/j.bbi.2012.10.009
   Michie S, 2008, APPL PSYCHOL-INT REV, V57, P660, DOI 10.1111/j.1464-0597.2008.00341.x
   Powell R, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008646.pub2
   Rosenkranz MA, 2013, BRAIN BEHAV IMMUN, V27, P174, DOI 10.1016/j.bbi.2012.10.013
   Schnur JB, 2008, ANESTH ANALG, V106, P440, DOI 10.1213/ane.0b013e31815edb13
   Schnur Julie B, 2008, Contemp Hypn, V25, P114, DOI 10.1002/ch.364
   Serra MB, 2017, INT J INFLAMM, V2017, DOI 10.1155/2017/3406215
   Speca M, 2000, PSYCHOSOM MED, V62, P613, DOI 10.1097/00006842-200009000-00004
   Nunes DFT, 2007, J PSYCHOSOM RES, V63, P647, DOI 10.1016/j.jpsychores.2007.07.004
   Vin-Raviv N, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129169
   Williams VSL, 2010, HEALTH QUAL LIFE OUT, V8, DOI 10.1186/1477-7525-8-57
   Yost KJ, 2011, J CLIN EPIDEMIOL, V64, P507, DOI 10.1016/j.jclinepi.2010.11.018
NR 36
TC 25
Z9 28
U1 0
U2 22
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD SEP
PY 2018
VL 24
IS 9-10
BP 916
EP 925
DI 10.1089/acm.2018.0069
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA GU6VP
UT WOS:000445455600009
PM 30247967
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Wong, RKW
   James, JL
   Sagar, S
   Wyatt, G
   Nguyen-Tân, PF
   Singh, AK
   Lukaszczyk, B
   Cardinale, F
   Yeh, AM
   Berk, L
AF Wong, Raimond K. W.
   James, Jennifer L.
   Sagar, Stephen
   Wyatt, Gwen
   Phuc Felix Nguyen-Tan
   Singh, Anurag K.
   Lukaszczyk, Barbara
   Cardinale, Francis
   Yeh, Alexander M.
   Berk, Lawrence
TI Phase 2 results from Radiation Therapy Oncology Group Study 0537 A Phase
   2/3 Study Comparing Acupuncture-Like Transcutaneous Electrical Nerve
   Stimulation Versus Pilocarpine in Treating Early Radiation-Induced
   Xerostomia
SO CANCER
LA English
DT Article
DE head and neck cancer; xerostomia; radiation; acupuncture;
   acupuncture-like transcutaneous electrical nerve stimulation
ID QUALITY-OF-LIFE; CANCER-PATIENTS; SALIVARY-GLANDS; HEAD; IRRADIATION;
   RADIOTHERAPY; RELEASE; INCREASES
AB BACKGROUND: In this phase 2 component of a multi-institutional, phase 2/3, randomized trial, the authors assessed the feasibility and preliminary efficacy of acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) in reducing radiation-induced xerostomia. METHODS: Patients with cancer of the head and neck who were 3 to 24 months from completing radiotherapy with or without chemotherapy (RT +/- C) and who were experiencing xerostomia symptoms with basal whole saliva production =0.1 mL per minute and were without recurrence were eligible. Patients received twice weekly ALTENS sessions (24 sessions over 12 weeks) using a proprietary electrical stimulation unit. The primary study objective was to assess the feasibility of ALTENS treatment. Patients were considered compliant if 19 of 24 ALTENS sessions were delivered, and the targeted compliance rate was 85%. Secondary objectives measured treatment-related toxicities and the effect of ALTENS on overall radiation-induced xerostomia burden using the University of Michigan Xerostomia-Related Quality of Life Scale (XeQOLS). RESULTS: Of 48 accrued patients, 47 were evaluable. The median age was 60 years, 84% of patients were men, 70% completed RT +/- C for >12 months, and 21% had previously received pilocarpine. Thirty-four patients completed all 24 ALTENS sessions, 9 patients completed 20 to 23 sessions, and 1 patient completed 19 sessions, representing a 94% total compliance rate. Six-month XeQOLS scores were available for 35 patients and indicated that 30 patients (86%) achieved a positive treatment response with a mean +/- standard deviation reduction of 35.9% +/- 36.1%. Five patients developed grade 1 or 2 gastrointestinal toxicity, and 1 had a grade 1 pain event. CONCLUSIONS: The current results indicated that ALTENS treatment for radiation-induced xerostomia can be delivered uniformly in a cooperative, multicenter setting and produces possible beneficial treatment response. Given these results, the phase 3 component of this study was initiated. Cancer 2012. (c) 2011 American Cancer Society.
C1 [Wong, Raimond K. W.; Sagar, Stephen] McMaster Univ, Juravinski Canc Ctr, Dept Oncol, Hamilton, ON L8V 5C2, Canada.
   [James, Jennifer L.] Ctr Stat, Radiat Therapy Oncol Grp, Philadelphia, PA USA.
   [Wyatt, Gwen] Michigan State Univ, Coll Nursing, E Lansing, MI 48824 USA.
   [Phuc Felix Nguyen-Tan] Montreal Univ Hosp, Dept Radiat Oncol, Montreal, PQ, Canada.
   [Singh, Anurag K.] Roswell Pk Canc Inst, Dept Radiat Med, Buffalo, NY 14263 USA.
   [Lukaszczyk, Barbara] John H Stroger Jr Hosp, Cook Cty Minor Based Community Clin Oncol Prog, Dept Med Oncol, Chicago, IL USA.
   [Cardinale, Francis] Hosp St Raphael, Dept Radiat Oncol, New Haven, CT 06511 USA.
   [Yeh, Alexander M.] Indiana Univ Hlth, Dept Radiat Oncol, Indianapolis, IN USA.
   [Berk, Lawrence] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Radiat Oncol, Tampa, FL 33682 USA.
C3 McMaster University; Radiation Therapy Oncology Group (RTOG); Michigan
   State University; Universite de Montreal; Roswell Park Comprehensive
   Cancer Center; John H Stroger Junior Hospital Cook County; Hospital
   Saint Raphael; Indiana University Health; IU Health University Hospital;
   H Lee Moffitt Cancer Center & Research Institute; State University
   System of Florida; University of South Florida
RP Wong, RKW (corresponding author), McMaster Univ, Juravinski Canc Ctr, Dept Radiat Oncol, 699 Concess St, Hamilton, ON L8V 5C2, Canada.
EM raimond.wong@jcc.hhsc.ca
RI ; Berk, Lawrence/AGD-4698-2022
OI Sagar, Stephen/0009-0002-9013-1989; Berk, Lawrence/0000-0002-8233-2417
FU RTOG [U10 CA21661]; NCI [U10 CA37422]
FX This work was supported by RTOG grant U10 CA21661 and Community Clinical
   Oncology Program grant U10 CA37422 from the NCI.
CR [Anonymous], 1998, Phys Ther Rev
   BLOM M, 1993, J ORAL REHABIL, V20, P541, DOI 10.1111/j.1365-2842.1993.tb01641.x
   Blom M, 2000, ORAL DIS, V6, P15
   BUSUTTIL A, 1977, CLIN OTOLARYNGOL, V2, P199, DOI 10.1111/j.1365-2273.1977.tb01358.x
   Cheng R, 1986, CLIN J PAIN, V2, P143, DOI DOI 10.1097/00002508-198602030-00001
   Cheng Xin-Nong., 1987, Chinese acupuncture and moxibustion
   Cho JH, 2008, J ALTERN COMPLEM MED, V14, P523, DOI 10.1089/acm.2007.0793
   Clavel S, 2011, INT J RAD ONCOL BIOL
   Dawidson I, 1999, NEUROPEPTIDES, V33, P244, DOI 10.1054/npep.1999.0759
   Dawidson I, 1998, LIFE SCI, V63, P659, DOI 10.1016/S0024-3205(98)00317-8
   Dawidson I, 1998, NEUROPEPTIDES, V32, P543, DOI 10.1016/S0143-4179(98)90083-X
   Deng G, 2008, BMC COMPLEM ALTERN M, V8, DOI 10.1186/1472-6882-8-37
   Ditto B., 2011, Journal of Behavioral Medicine, P1
   Eisbruch A, 1996, INT J RADIAT ONCOL, V36, P469, DOI 10.1016/S0360-3016(96)00264-7
   Eisbruch A, 1998, INT J RADIAT ONCOL, V41, P559, DOI 10.1016/S0360-3016(98)00082-0
   Eisbruch A, 1999, INT J RADIAT ONCOL, V45, P577, DOI 10.1016/S0360-3016(99)00247-3
   FOX EJ, 1976, PAIN, V2, P141, DOI 10.1016/0304-3959(76)90109-3
   Frank R M, 1965, Actual Odontostomatol (Paris), V19, P129
   Gadsby JG, 2000, COCHRANE DB SYST REV
   Garcia MK, 2009, HEAD NECK-J SCI SPEC, V31, P1360, DOI 10.1002/hed.21110
   Greenspan D, 1996, Oncology (Williston Park), V10, P7
   Henson BS, 2001, ORAL ONCOL, V37, P84, DOI 10.1016/S1368-8375(00)00063-4
   Henson BS, 1999, ORAL ONCOL, V35, P234, DOI 10.1016/S1368-8375(98)00104-3
   HOWSON DC, 1978, PHYS THER, V58, P1467, DOI 10.1093/ptj/58.12.1467
   Johnstone PAS, 2002, CANCER, V94, P1151, DOI 10.1002/cncr.10348
   Johnstone PAS, 2001, INT J RADIAT ONCOL, V50, P353, DOI 10.1016/S0360-3016(00)01530-3
   Kahn ST, 2005, ONCOLOGY-NY, V19, P1827
   Kramar A, 1996, BRIT J CANCER, V74, P1317, DOI 10.1038/bjc.1996.537
   LAITINEN J, 1976, American Journal of Chinese Medicine, V4, P169, DOI 10.1142/S0192415X76000214
   Pfister DG, 2010, J CLIN ONCOL, V28, P2565, DOI 10.1200/JCO.2009.26.9860
   Pomeranz B., 1987, AM J ELECTROMED, V2, P22
   Proctor GB, 2007, AUTON NEUROSCI-BASIC, V133, P3, DOI 10.1016/j.autneu.2006.10.006
   Sakatani K, 2010, ADV EXP MED BIOL, V662, P455, DOI 10.1007/978-1-4419-1241-1_65
   SCHNEYER CA, 1993, AM J PHYSIOL, V264, pG935, DOI 10.1152/ajpgi.1993.264.5.G935
   Ship JA, 1997, J DENT RES, V76, P807, DOI 10.1177/00220345970760031401
   Simcock R, 2009, ACUPUNCT MED, V27, P109, DOI 10.1136/aim.2009.000935
   TALAL N, 1992, RHEUMATOL INT, V12, P43, DOI 10.1007/BF00300975
   Vergeer MR, 2009, INT J RADIAT ONCOL, V74, P1, DOI 10.1016/j.ijrobp.2008.07.059
   WANG KM, 1985, SCI SIN B-CHEM B A M, V28, P963
   WEISS WW, 1986, J ORAL MAXIL SURG, V44, P845, DOI 10.1016/0278-2391(86)90219-3
   Wong RKW, 2003, INT J RADIAT ONCOL, V57, P472, DOI 10.1016/S0360-3016(03)00572-8
NR 41
TC 39
Z9 45
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD SEP 1
PY 2012
VL 118
IS 17
BP 4244
EP 4252
DI 10.1002/cncr.27382
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 993GN
UT WOS:000307845200022
PM 22252927
DA 2026-01-16
ER

PT J
AU Li, YF
   Xing, X
   Shi, X
   Yan, PJ
   Chen, YJ
   Li, MX
   Zhang, WY
   Li, XX
   Yang, KH
AF Li, Yanfei
   Xing, Xin
   Shi, Xiue
   Yan, Peijing
   Chen, Yajing
   Li, Meixuan
   Zhang, Weiyi
   Li, Xiuxia
   Yang, Kehu
TI The effectiveness of music therapy for patients with cancer: A
   systematic review and meta-analysis
SO JOURNAL OF ADVANCED NURSING
LA English
DT Review
DE cancer; music therapy; nursing; pain; quality of life; supportive care;
   systematic review
ID QUALITY-OF-LIFE; MEDICINE 5-ELEMENT MUSIC; REPORTING CHARACTERISTICS;
   METHODOLOGICAL QUALITY; PAIN; ANXIETY; INTERVENTIONS; CHEMOTHERAPY;
   ACUPUNCTURE; DEPRESSION
AB Aims To assess the effectiveness of music therapy on the quality of life, anxiety, depression and pain of patients with cancer.
   Design Systematic review.
   Data Sources Five electronic databases were searched in September 2018 for randomized controlled trials evaluating music therapy for patients with cancer.
   Review Methods The quality of the studies was assessed using the risk of bias tool recommended by the Cochrane Handbook Version 5.1.0 and the Revman version 5.3 software was used to perform the meta-analysis. The outcomes were overall quality of life, anxiety, depression and pain.
   Results A total of 19 trials evaluating 1,548 patients were included in this study, of which 765 were in the control group and 783 in the experimental group. Compared with standard care, music therapy can significantly increase the score of the overall quality of life in patients with cancer. In addition, music therapy was found to be more effective for decreasing the score of anxiety, depression and pain.
   Conclusion Music therapy can improve the overall quality of life of patients with cancer, with an observed optimal intervention duration of 1-2 months. Meanwhile, anxiety, depression and pain are improved as well. Nevertheless, high-quality trials are still needed to further determine the effects of music intervention in supportive cancer care.
C1 [Li, Yanfei; Chen, Yajing; Li, Meixuan; Zhang, Weiyi; Li, Xiuxia; Yang, Kehu] Lanzhou Univ, Evidence Based Social Sci Res Ctr, Sch Publ Hlth, Lanzhou, Peoples R China.
   [Li, Yanfei; Li, Meixuan; Zhang, Weiyi; Li, Xiuxia; Yang, Kehu] Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou, Peoples R China.
   [Xing, Xin; Yang, Kehu] Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Peoples R China.
   [Shi, Xiue] Res Inst Evidence Based Rehabil Med Gansu Prov, Lanzhou, Peoples R China.
   [Shi, Xiue] Gansu Prov Hosp Rehabil Ctr, Lanzhou, Peoples R China.
   [Yan, Peijing; Yang, Kehu] Gansu Prov Hosp, Inst Clin Res & Evidence Based Med, Lanzhou, Peoples R China.
C3 Lanzhou University; Lanzhou University
RP Yang, KH (corresponding author), Lanzhou Univ, Sch Basic Med Sci, Lanzhou 730000, Peoples R China.; Li, XX (corresponding author), Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Peoples R China.
EM lixiuxia@lzu.edu.cn; kehuyangebm2006@126.com
RI ; Chen, Yajing/AAU-4078-2021
OI Yang, Hehu/0000-0001-7864-3012; 
FU Fundamental Research Funds for the Central Universities: Evidence Based
   Social Science Research [18LZUJBWZX006, 2019jbkyjc002]; China Medical
   Board Open Project Funding: Tracking and Evaluating Quality (TEQ) of
   Rural Health Services in NW China: Tool kits for rural clinic quality
   management and capacity building [CMB#17-279]; Special Fund for Soft
   Science in Gansu Province: Study on the Measures to Improve the Quality
   of Rural Health Services in Gansu Province [18CX1ZA043]
FX Supported by the Fundamental Research Funds for the Central
   Universities: Evidence Based Social Science Research,Grant/Award
   Numbers: 18LZUJBWZX006, 2019jbkyjc002; China Medical Board Open Project
   Funding: Tracking and Evaluating Quality (TEQ) of Rural Health Services
   in NW China: Tool kits for rural clinic quality management and capacity
   building, Grant/Award Number: CMB#17-279; Special Fund for Soft Science
   in Gansu Province: Study on the Measures to Improve the Quality of Rural
   Health Services in Gansu Province, Grant/Award Number: 18CX1ZA043.
CR Alcantara-Silva TR, 2018, INTEGR CANCER THER, V17, P628, DOI 10.1177/1534735418757349
   Archie P, 2013, SUPPORT CARE CANCER, V21, P2609, DOI 10.1007/s00520-013-1841-4
   Bieligmeyer S, 2018, COMPLEMENT THER MED, V40, P171, DOI 10.1016/j.ctim.2018.03.002
   Bradt J, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007169.pub2
   Bultz BD, 2006, PSYCHO-ONCOLOGY, V15, P93, DOI 10.1002/pon.1022
   Burns DS, 2001, J MUSIC THER, V38, P51, DOI 10.1093/jmt/38.1.51
   Burrai F, 2014, HOLIST NURS PRACT, V28, P301, DOI 10.1097/HNP.0000000000000041
   Chen C, 2017, J TRADIT CHIN MED, V37, P64
   Dvorak AbbeyL., 2012, Dissertation Abstracts International, V72, P4366, DOI [10.17077/etd.3zbutejc, DOI 10.17077/ETD.3ZBUTEJC]
   Gao YY, 2019, J PAIN SYMPTOM MANAG, V57, P319, DOI 10.1016/j.jpainsymman.2018.10.504
   Ge L, 2018, J CLIN EPIDEMIOL, V93, P45, DOI 10.1016/j.jclinepi.2017.10.012
   Geretsegger M, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004025.pub4
   Hanser Suzanne B, 2006, J Soc Integr Oncol, V4, P116, DOI 10.2310/7200.2006.014
   Hilliard RE, 2003, J MUSIC THER, V40, P113, DOI 10.1093/jmt/40.2.113
   Holland JC, 2010, J NATL COMPR CANC NE, V8, P448, DOI 10.6004/jnccn.2010.0034
   Huang ST, 2010, INT J NURS STUD, V47, P1354, DOI 10.1016/j.ijnurstu.2010.03.008
   Jasemi M, 2016, INDIAN J PALLIAT CAR, V22, P455, DOI 10.4103/0973-1075.191823
   Keenan A, 2015, ONCOL NURS FORUM, V42, pE368, DOI 10.1188/15.ONF.E368-E375
   Kern P, 2017, J MUSIC THER, V54, P255, DOI 10.1093/jmt/thx011
   Li XM, 2011, BREAST CANCER RES TR, V128, P411, DOI 10.1007/s10549-011-1533-z
   Li XX, 2015, HEALTH POLICY, V119, P503, DOI 10.1016/j.healthpol.2014.09.002
   Li XX, 2017, PAIN PRACT, V17, P1066, DOI 10.1111/papr.12555
   Li-hau L., 2016, Medical Innovation of China, V13, P97, DOI [10.3969/j.issn.1674-4985.2016.17.027, DOI 10.3969/J.ISSN.1674-4985.2016.17.027]
   Liao J, 2013, CHIN J INTEGR MED, V19, P736, DOI 10.1007/s11655-013-1593-5
   Arruda MALB, 2016, J PALLIAT MED, V19, P943, DOI 10.1089/jpm.2015.0528
   Lin MF, 2011, J CLIN NURS, V20, P988, DOI 10.1111/j.1365-2702.2010.03525.x
   Ma L, 2013, CURR ONCOL, V20, pE554, DOI 10.3747/co.20.1651
   Makhlouf SM, 2020, J CANCER EDUC, V35, P214, DOI 10.1007/s13187-019-01548-9
   McCarter K, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-017959
   Nightingale CL, 2013, INTEGR CANCER THER, V12, P393, DOI 10.1177/1534735413485817
   Ostermann T., 2012, BMC Complementary and Alternative Medicine, V12, P327, DOI DOI 10.1186/1472-6882-12-S1-P327
   Revicki DA, 2000, QUAL LIFE RES, V9, P887, DOI 10.1023/A:1008996223999
   [孙凤英 Sun Fengying], 2015, [护理学杂志, Journal of Nursing Science], V30, P35
   Tao WW, 2016, J PAIN SYMPTOM MANAG, V51, P728, DOI 10.1016/j.jpainsymman.2015.11.027
   Thanh NN, 2010, J PEDIATR ONCOL NURS, V27, P146, DOI 10.1177/1043454209355983
   Tsai HF, 2014, CANCER NURS, V37, pE35, DOI 10.1097/NCC.0000000000000116
   Tuinmann G, 2017, PSYCHO-ONCOLOGY, V26, P377, DOI 10.1002/pon.4142
   Wan Y, 2009, CHIN NURS RES, V23, P1172
   Warth M, 2014, BMC PALLIAT CARE, V13, DOI 10.1186/1472-684X-13-60
   Weatherall M, 2017, POSTGRAD MED J, V93, P696, DOI 10.1136/postgradmedj-2017-135034
   Xiao-hong Y., 2008, CHINESE J PRACTICAL, P11, DOI [10.3760/cma.j.issn.1672-7088.2008.06.005, DOI 10.3760/CMA.J.ISSN.1672-7088.2008.06.005]
   Yao L, 2016, J CLIN EPIDEMIOL, V74, P73, DOI 10.1016/j.jclinepi.2016.01.003
   Zhai W, 2017, World Chinese Journal of Digestology, V25, P388, DOI [10.11569/wcjd.v25.i4.388, 10.11569/wcjd.v25.i4.388, DOI 10.11569/WCJD.V25.I4.388]
   Zhang JM, 2012, SUPPORT CARE CANCER, V20, P3043, DOI 10.1007/s00520-012-1606-5
NR 44
TC 94
Z9 110
U1 2
U2 90
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0309-2402
EI 1365-2648
J9 J ADV NURS
JI J. Adv. Nurs.
PD MAY
PY 2020
VL 76
IS 5
BP 1111
EP 1123
DI 10.1111/jan.14313
EA FEB 2020
PG 13
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA KY6DS
UT WOS:000514250700001
PM 32017183
OA gold
DA 2026-01-16
ER

PT J
AU Grant, SJ
   Marthick, M
   Lacey, J
AF Grant, Suzanne J.
   Marthick, Michael
   Lacey, Judith
TI Establishing an integrative oncology service in the Australian
   healthcare settingthe Chris O'Brien Lifehouse Hospital experience
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Integrative oncology; Supportive care; Complementary therapy; Holistic
   care; Integrative medicine
ID ALTERNATIVE MEDICINE; COMPLEMENTARY THERAPIES; CANCER-PATIENTS;
   LUNG-CANCER; PAIN; ATTITUDES; OUTCOMES; ANXIETY
AB Comprehensive cancer centres are on the rise as patients seek a more holistic approach to maintaining their wellbeing when living with a cancer diagnosis. Many cancer centres worldwide now incorporate a selection of evidence-based complementary therapies and qualified therapists into their offerings. The Chris O'Brien Lifehouse, a comprehensive cancer centre in Sydney, Australia, provides integrative oncology services including acupuncture, massage, reflexology, dietetics and exercise physiology for individual patients, along with group programmes, and an integrative and supportive care medical specialist. The purpose of this paper is to reflect on one model of integrative oncology service and approach to integration and team and service development.
C1 [Grant, Suzanne J.; Marthick, Michael; Lacey, Judith] Chris OBrien Lifehouse, POB M33, Camperdown, NSW 2050, Australia.
   [Grant, Suzanne J.; Lacey, Judith] Western Sydney Univ, Natl Inst Complementary Med, Locked Bag 1797, Penrith, NSW 2751, Australia.
   [Lacey, Judith] Univ Sydney, Sch Med, Camperdown, NSW 2050, Australia.
C3 Chris O'Brien Lifehouse; Western Sydney University; University of Sydney
RP Grant, SJ (corresponding author), Chris OBrien Lifehouse, POB M33, Camperdown, NSW 2050, Australia.; Grant, SJ (corresponding author), Western Sydney Univ, Natl Inst Complementary Med, Locked Bag 1797, Penrith, NSW 2751, Australia.
EM suzanne.grant@lh.org.au
RI Lacey, Judith/AAI-5754-2021; Grant, Suzanne Jane/JTT-6993-2023
OI Lacey, Judith/0000-0002-3751-406X; Grant, Suzanne
   Jane/0000-0002-9491-203X
CR Amichai T, 2012, EUR J ONCOL NURS, V16, P520, DOI 10.1016/j.ejon.2012.01.004
   Basch E, 2016, J CLIN ONCOL, V34, P557, DOI 10.1200/JCO.2015.63.0830
   Bell RM, 2010, CLIN J ONCOL NURS, V14, P365, DOI 10.1188/10.CJON.365-370
   Boon HS, 2008, BMC COMPLEM ALTERN M, V8, DOI 10.1186/1472-6882-8-32
   Buffart LM, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-559
   Cassileth BR, 2007, CHEST, V132, p340S, DOI 10.1378/chest.07-1389
   Coulter ID, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-191
   Deng G, 2008, CURR ONCOL, V15, pS68
   Deng G, 2005, CA-CANCER J CLIN, V55, P109, DOI 10.3322/canjclin.55.2.109
   Deng GE, 2013, CHEST, V143, pE420, DOI 10.1378/chest.12-2364
   Deng Gary E, 2009, J Soc Integr Oncol, V7, P85
   Eisenberg DM, 2016, ACAD MED, V91, P1223, DOI 10.1097/ACM.0000000000001173
   Filshie Jacqueline, 2006, Acupunct Med, V24, P172
   Frenkel M, 2008, HEMATOL ONCOL CLIN N, V22, P727, DOI 10.1016/j.hoc.2008.04.002
   GIRGS A, 2015, CANC FORUM, V39, P2
   Grant S, ADV INTEGR MED, V2, P116
   Grant SJ, 2017, SUPPORT CARE CANCER
   Greenlee H, 2017, CANC J CLIN
   Herman PM, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-001046
   Hibbard JH, 2013, HEALTH AFFAIR, V32, P216, DOI 10.1377/hlthaff.2012.1064
   Horneber M, 2012, INTEGR CANCER THER, V11, P187, DOI 10.1177/1534735411423920
   Hunter J, 2013, COMPLEMENT THER CLIN, V19, P20, DOI 10.1016/j.ctcp.2012.10.002
   Hyodo I, 2003, CANCER, V97, P2861, DOI 10.1002/cncr.11402
   Johnson Jill R., 2014, Journal of the National Cancer Institute Monographs, P330, DOI 10.1093/jncimonographs/lgu030
   Kerridge IH, 2004, MED J AUSTRALIA, V181, P164, DOI 10.5694/j.1326-5377.2004.tb06211.x
   King T, 2015, CL LYMPH MYELOM LEUK, V15, pe317, DOI 10.1016/j.clml.2015.08.090
   Kligler B, 2011, AM J MANAG CARE, V17, P779
   Lacey JDH, 2017, MULT ASS SUPP CAR CA, P25
   Lu WD, 2013, CURR PAIN HEADACHE R, V17, DOI 10.1007/s11916-013-0321-3
   Mittring N, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/316950
   Oh B, 2010, ASIA-PAC J CLIN ONCO, V6, P342, DOI 10.1111/j.1743-7563.2010.01329.x
   Pérard M, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0696-2
   Phillips SM, 2014, CANCER EPIDEM BIOMAR, V23, P687, DOI 10.1158/1055-9965.EPI-13-1355
   Rademakers J, 2011, BMJ QUAL SAF, V20, P326, DOI 10.1136/bmjqs.2010.042358
   Risberg T, 2004, EUR J CANCER, V40, P529, DOI 10.1016/j.ejca.2003.11.011
   Robotin M, 2012, COMPLEMENT THER MED, V20, P345, DOI 10.1016/j.ctim.2012.04.001
   Robotin MC, 2006, MED J AUSTRALIA, V185, P377, DOI 10.5694/j.1326-5377.2006.tb00614.x
   Sagar SM, 2008, CURR ONCOL, V15, pS78
   Seely DM, 2012, CURR ONCOL, V19, pE436, DOI 10.3747/co.19.1182
   Smith C., 2017, INTEGRATIVE ONCOLOGY
   Yun Hyeongjun, 2017, Journal of the National Cancer Institute Monographs, P29, DOI [10.1093/jncimonographs/lgx004, 10.1093/jncimonographs/lgx004]
NR 41
TC 22
Z9 23
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JUN
PY 2019
VL 27
IS 6
BP 2069
EP 2076
DI 10.1007/s00520-018-4460-2
PG 8
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA HW8QK
UT WOS:000466954400014
PM 30225572
DA 2026-01-16
ER

PT J
AU Blackburn, H
   West, S
AF Blackburn, Helen
   West, Sandra
TI 1 Management of Postembolization Syndrome Following Hepatic
   Transarterial Chemoembolization for Primary or Metastatic Liver Cancer
SO CANCER NURSING
LA English
DT Article
DE Fever; Nausea; Pain; Postembolization syndrome; Transarterial
   chemoembolization
ID TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; IRINOTECAN-ELUTING BEADS;
   QUALITY-OF-LIFE; HEPATOCELLULAR-CARCINOMA; INTRAARTERIAL LIDOCAINE;
   PAIN; FEVER; EMBOLIZATION; MALIGNANCIES; TOXICITY
AB Background: Transarterial chemoembolization (TACE) is an established treatment in managing liver primary neoplasms or liver metastases. Postembolization syndrome (PES) is a common adverse event defined as fever without associated sepsis, pain in the right upper quadrant, and nausea and/or vomiting.
   Objective: This integrative review aims to identify effective management strategies for PES or one of its characterizing symptoms (fever, pain, and nausea and/or vomiting).
   Methods: Searches of electronic databases MEDLINE, EMBASE, and CINAHL were conducted. Fifteen articles were identified for inclusion. Seven addressed all symptoms of PES, and 8 studies focused on individual symptoms of PES.
   Results: Interventions identified are intra-arterial lidocaine, oral and intravenous analgesics, steroids, wrist-ankle acupuncture, antibiotics, and 5-HT3 receptor antagonists. Findings are explicated according to individual symptoms of PES. Intra-arterial lidocaine, steroids, and a 5-HT3 receptor antagonist are found to offer potential benefit in the management of PES symptoms.
   Conclusion: A number of interventions have shown potential benefit in the management of PES. A systemic approach using combination therapy is necessary to effectively manage characterizing symptoms. Further research is needed to determine the impact of primary disease site, TACE technique, and chemotherapeutic agent on PES.
   Implications for Practice: Oncology nurses are uniquely placed to undertake thorough patient assessment after TACE and implement early intervention to effectively manage PES.
C1 [Blackburn, Helen] North Shore Private Hosp, Level 4 North,Westborne St, St Leonards, NSW 2065, Australia.
   [Blackburn, Helen; West, Sandra] Univ Sydney, Sydney Nursing Sch, Sydney, NSW 2006, Australia.
C3 University of Sydney
RP Blackburn, H (corresponding author), North Shore Private Hosp, Level 4 North,Westborne St, St Leonards, NSW 2065, Australia.
EM blackburnh@ramsayhealth.com.au
CR Aliberti C, 2011, ANTICANCER RES, V31, P4581
   Basile A, 2012, CARDIOVASC INTER RAD, V35, P765, DOI 10.1007/s00270-012-0423-z
   Bissler JJ, 2002, AM J KIDNEY DIS, V39, P966, DOI 10.1053/ajkd.2002.32770
   Cahill Bridget A, 2005, Clin J Oncol Nurs, V9, P69, DOI 10.1188/05.CJON.69-75
   CASTELLS A, 1995, J HEPATOL, V22, P410, DOI 10.1016/0168-8278(95)80103-0
   Cornelis F, 2010, AM J TRANSPLANT, V10, P2363, DOI 10.1111/j.1600-6143.2010.03251.x
   de Baere T, 2008, J VASC INTERV RADIOL, V19, P855, DOI 10.1016/j.jvir.2008.01.030
   Des Jarlais DC, 2004, AM J PUBLIC HEALTH, V94, P361, DOI 10.2105/AJPH.94.3.361
   Feng YL, 2009, J ALTERN COMPLEM MED, V15, P175, DOI 10.1089/acm.2008.0093
   Fiorentini G, 2012, ANTICANCER RES, V32, P1387
   Fiorentini G, 2008, HEPATO-GASTROENTEROL, V55, P2077
   Hartnell GG, 1999, CARDIOVASC INTER RAD, V22, P293, DOI 10.1007/s002709900391
   Jun CH, 2013, WORLD J GASTROENTERO, V19, P284, DOI 10.3748/wjg.v19.i2.284
   Kogut MJ, 2013, J VASC INTERV RADIOL, V24, P326, DOI 10.1016/j.jvir.2012.11.019
   Lee SH, 2001, CARDIOVASC INTER RAD, V24, P368, DOI 10.1007/s00270-001-0073-z
   Leung DA, 2001, J VASC INTERV RADIOL, V12, P321, DOI 10.1016/S1051-0443(07)61911-3
   Li CP, 2008, SCAND J GASTROENTERO, V43, P992, DOI 10.1080/00365520801971744
   Malagari K, 2011, CARDIOVASC INTER RAD, V34, P774, DOI 10.1007/s00270-010-0044-3
   Martin RCG, 2010, CARDIOVASC INTER RAD, V33, P960, DOI 10.1007/s00270-010-9937-4
   Molgaard C P, 1990, J Vasc Interv Radiol, V1, P81, DOI 10.1016/S1051-0443(90)72508-0
   Narayanan G, 2013, ANTICANCER RES, V33, P2077
   OKEN MM, 1982, AM J CLIN ONCOL-CANC, V5, P649, DOI 10.1097/00000421-198212000-00014
   Perez-Rojas E, 2012, CLIN J ONCOL NURS, V16, P83, DOI 10.1188/12.CJON.83-85
   Prajapati HJ, 2012, J VASC INTERV RADIOL, V23, P1286, DOI 10.1016/j.jvir.2012.07.003
   Romano Maurizio, 2003, Radiol Med, V105, P350
   Salem R, 2013, CLIN GASTROENTEROL H, V11, P1358, DOI 10.1016/j.cgh.2013.04.028
   Shim JH, 2009, J VASC INTERV RADIOL, V20, P209, DOI 10.1016/j.jvir.2008.10.021
   Shun SC, 2012, ONCOLOGIST, V17, P732, DOI 10.1634/theoncologist.2011-0368
   Siskin Gary P, 2002, Tech Vasc Interv Radiol, V5, P35, DOI 10.1053/tvir.2002.124727
   Sohara N, 1999, SUPPORT CARE CANCER, V7, P84, DOI 10.1007/s005200050232
   Whittemore R, 2005, J ADV NURS, V52, P546, DOI 10.1111/j.1365-2648.2005.03621.x
   Wilkes G, 2009, Oncology Nursing Drug Handbook
   Zeng K, 2014, AM J CHINESE MED, V42, P289, DOI 10.1142/S0192415X14500190
   Zhou B, 2012, RADIOLOGY, V262, P1014, DOI 10.1148/radiol.11110552
NR 34
TC 73
Z9 86
U1 0
U2 51
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD SEP-OCT
PY 2016
VL 39
IS 5
BP E1
EP E18
DI 10.1097/NCC.0000000000000302
PG 18
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA DW9LX
UT WOS:000383982600001
PM 26484962
DA 2026-01-16
ER

PT J
AU Feng, W
   Du, XX
   Zhao, YX
AF Feng, Wei
   Du, Xixi
   Zhao, Yuxin
TI Enhancing treatment of lumbar disc herniation with Erxian decoction and
   auricular acupoint pressure: A randomized controlled trial
SO MEDICINE
LA English
DT Article
DE auricular acupoint pressure; Erxian decoction; lumbar disc herniation;
   Traditional Chinese Medicine
ID LOW-BACK-PAIN; CHINESE HERBAL FORMULA; POINT ACUPRESSURE; DISORDERS;
   RELIEF
AB Objective: The incidence of lumbar disc herniation (LDH) is on the rise annually, with an emerging trend of affecting younger age groups. This study aims to investigate the clinical effectiveness of combining Erxian decoction with auricular acupoint pressure therapy in treating LDH. Our objective is to furnish evidence supporting the incorporation of traditional Chinese medicine (TCM) rehabilitation techniques in clinical settings. Methods: This randomized controlled trial enrolled 102 patients diagnosed with LDH and allocated them into Control and Intervention groups. The Control group underwent a 2-week rehabilitation regimen, whereas the Intervention group received an augmented treatment comprising Erxian decoction along with auricular acupoint pressure therapy based on the Control group. Main outcome measures included 3 scales - visual analog scale (VAS), Japanese Orthopedic Association (JOA), and Oswestry Disability Index - as well as 3 inflammatory markers: C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). Additionally, pressure pain threshold and pain tolerance threshold values were evaluated. Participants were assessed at baseline, on 14-day, and on 28-day posttreatment. Results: After 2 weeks of treatment, both the Control and Intervention groups exhibited significant improvements in the VAS, JOA, ODI, CRP, IL-6, TNF-alpha, pressure pain threshold, and pain tolerance threshold (P < .05). These improvements persisted at the 28-day in the VAS, JOA, and ODI scores (P < .05). On 14-day, the Intervention group showed significantly better outcomes compared to the Control group in terms of the VAS, JOA, ODI, CRP, TNF-alpha, and pressure pain threshold (P < .05). Conclusion: Compared to conventional rehabilitation therapy, the combination of Erxian decoction and auricular acupoint pressure therapy demonstrates clear benefits in alleviating symptoms in patients with LDH. This approach offers fresh perspectives and substantiates evidence for future treatment strategies in managing LDH.
C1 [Feng, Wei; Du, Xixi; Zhao, Yuxin] Shangqiu Hosp Tradit Chinese Med, Dept Rehabil, 38,Liangyuan Dist, Shangqiu, Henan Province, Peoples R China.
   [Zhao, Yuxin] Shangqiu Hosp Tradit Chinese Med, Dept Orthoped, Shangqiu, Peoples R China.
RP Zhao, YX (corresponding author), Shangqiu Hosp Tradit Chinese Med, Dept Rehabil, 38,Liangyuan Dist, Shangqiu, Henan Province, Peoples R China.
EM 15937002277@163.com; 15660641156@163.com; hnzhaoyuxin666@163.com
FU Henan Province Traditional Chinese Medicine Scientific Research Special
   Project [2022ZY1204]
FX Henan Province Traditional Chinese Medicine Scientific Research Special
   Project (2022ZY1204).
CR Andersen MO, 2022, GLOB SPINE J, V12, P627, DOI 10.1177/2192568220960399
   Arts MP, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000014410
   Azimi P, 2012, J ORTHOP SCI, V17, P341, DOI 10.1007/s00776-012-0232-x
   Benzakour T, 2019, INT ORTHOP, V43, P841, DOI 10.1007/s00264-018-4247-6
   Bui MMP., 2023, MedPharmRes, V7, P30
   Cai CY, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/6754730
   Chesterton LS, 2007, CLIN J PAIN, V23, P760, DOI 10.1097/AJP.0b013e318154b6ae
   Cheung HP, 2017, CHIN MED-UK, V12, DOI 10.1186/s13020-016-0123-8
   Cook CE, 2021, SPINE, V46, pE118, DOI 10.1097/BRS.0000000000003732
   Dimitroulas T, 2019, PAIN MED, V20, P1678, DOI 10.1093/pm/pny214
   Govindarajan V, 2021, NEUROSURG FOCUS, V50, DOI 10.3171/2021.3.FOCUS2175
   Hou PW, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/495684
   Katz JN, 2006, J BONE JOINT SURG AM, V88A, P21, DOI 10.2106/JBJS.E.01273
   Kersten P, 2012, J REHABIL MED, V44, P609, DOI 10.2340/16501977-0999
   Li JJ, 2007, CHIN J INTEGR MED, V13, P67, DOI 10.1007/s11655-007-0067-z
   Li JY, 2017, CLIN INTERV AGING, V12, P45, DOI 10.2147/CIA.S117597
   Liu JT, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021069
   Liu MM, 2021, PAIN MANAG NURS, V22, P268, DOI 10.1016/j.pmn.2020.07.007
   Mo ZM, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6821310
   Parker SL, 2015, CLIN ORTHOP RELAT R, V473, P1988, DOI 10.1007/s11999-015-4193-1
   Qin LP, 2008, J ETHNOPHARMACOL, V118, P271, DOI 10.1016/j.jep.2008.04.009
   Rogerson A, 2019, INT ORTHOP, V43, P969, DOI 10.1007/s00264-018-4246-7
   Santoro A, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/457390
   Shen X., 2020, Jiangsu J Tradit Chin Med, V52, P35
   Slade GD, 2011, PAIN, V152, P2802, DOI 10.1016/j.pain.2011.09.005
   Vialle Luis Roberto, 2010, Rev. bras. ortop., V45, P17
   Wan ZY, 2022, FRONT SURG, V9, DOI 10.3389/fsurg.2022.814531
   Wang Y, 2019, J ETHNOPHARMACOL, V234, P8, DOI 10.1016/j.jep.2019.01.010
   Wu J., 2010, Xin Zhong Yi, V42, P25
   Xue LM, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/490843
   Ye BingLin Ye BingLin, 2016, Chinese Journal of Information on Traditional Chinese Medicine, V23, P23
   Yeh CH, 2014, MED ACUPUNCT, V26, P31, DOI 10.1089/acu.2013.1015
   Yeh CH, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/934670
   Yeh CH, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/375173
   Yeh ML, 2013, J ALTERN COMPLEM MED, V19, P313, DOI 10.1089/acm.2011.0665
   Yin Z, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000023696
   Zhang YG, 2009, SPINE, V34, pE918, DOI 10.1097/BRS.0b013e3181a3c2de
   Zhou M.W., 2017, Chin J Rehabil Med, V32, P129
   Zhu LG, 2020, J ETHNOPHARMACOL, V263, DOI 10.1016/j.jep.2020.113117
   Zhu Q., 2012, Zhong HuaZhong Yi Yao Xue Kan, V42, P2806
   Zoia C, 2017, INT J SPINE SURG, V11, DOI 10.14444/4001
NR 41
TC 1
Z9 2
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL 12
PY 2024
VL 103
IS 28
AR e38899
DI 10.1097/MD.0000000000038899
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YS1X0
UT WOS:001270390400005
PM 38996119
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, JL
   Xu, DH
   Liu, YY
   Cao, Y
   He, J
   Liao, MX
AF Li, Jialing
   Xu, Danghan
   Liu, Yingyu
   Cao, Yang
   He, Jun
   Liao, Muxi
TI Acupuncture Treatment of Guillain-Barre Syndrome After Using Immune
   Checkpoint Inhibitors: A Case Report
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE acupuncture; Guillain-Barre syndrome; immune checkpoint inhibitors;
   immune-related adverse events; case report; limb weakness; numbness
ID DISEASE; PATHOGENESIS; MANAGEMENT; DIAGNOSIS; HEALTH; AXIS
AB Guillain-Barre syndrome(GBS) is an autoimmune-mediated peripheral neuropathy. Immune checkpoint inhibitors (ICIs) are the standard treatment for cancer and may lead to immune-related adverse events (irAEs) such as GBS. Corticosteroids, plasma exchange (PE), and intravenous immunoglobulin (IVIG) are currently accepted treatments for ICI-induced GBS. However, there are still adverse reactions, and the effect of relieving symptoms is not as good as expected. Safe and effective complementary replacement therapy to alleviate GBS symptoms and ameliorate the quality of life is urgently required. In this case, a 63-year-old man received ICI therapy and antitumor chemotherapy for lung malignancy. After two courses of treatment, the patient gradually developed limb weakness, numbness, and pain at the ends of the limbs, with cerebrospinal fluid (CSF) albuminocytological dissociation, and electromyography (EMG) suggested demyelinating changes and was diagnosed as GBS. Although the patient received high doses of intravenous gamma globulin and limb weakness symptoms were alleviated, there was still significant numbness and pain in the extremities. After four times of acupuncture treatments, the patient complained that the symptoms of limb numbness and fatigue were significantly alleviated without any discomfort. This case report may provide a new alternative and complementary therapy for immune checkpoint inhibitor-induced GBS, but more definitive and robust evidence is needed to support its efficacy.
C1 [Li, Jialing] Guangzhou Univ Chinese Med, Clin Sch Med 1, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Xu, Danghan; Cao, Yang; He, Jun; Liao, Muxi] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Xu, Danghan] Guangdong Prov Key Lab Tradit Chinese Med & Acupun, Guangzhou, Peoples R China.
   [Liu, Yingyu] Guangzhou Univ Chinese Med, Acupuncture & Rehabil Clin Sch Med, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine
RP Xu, DH; Liao, MX (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Peoples R China.; Xu, DH (corresponding author), Guangdong Prov Key Lab Tradit Chinese Med & Acupun, Guangzhou, Peoples R China.
EM xudanghan@126.com; 527938256@qq.com
RI Xu, Danghan/P-1067-2018
OI Xu, Danghan/0000-0001-9491-5815
FU Guangdong Provincial Key Laboratory of Traditional Chinese Medicine and
   Acupuncture [06]; Zhangjiawei National Famous and Old TCM Experts
   Inheritance Studio [149]; special fund Innovating and Strengthening the
   Hospital for preventive treatment of disease of the First Affiliated
   Hospital of Guangzhou University of Chinese Medicine [2019ZWB07];
   Guangdong Province Rural Science and Technology Commissioner Project
   [KTPYJ2021026]
FX This study was supported by Guangdong Provincial Key Laboratory of
   Traditional Chinese Medicine and Acupuncture (06), Zhangjiawei National
   Famous and Old TCM Experts Inheritance Studio (National Administration
   of Traditional Chinese Medicine [2012] No. 149), the special fund
   Innovating and Strengthening the Hospital for preventive treatment of
   disease of the First Affiliated Hospital of Guangzhou University of
   Chinese Medicine (2019ZWB07), and Guangdong Province Rural Science and
   Technology Commissioner Project (KTPYJ2021026).
CR Baek JY, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9100624
   Bennedsgaard K, 2020, J PERIPHER NERV SYST, V25, P377, DOI 10.1111/jns.12413
   Brahmer JR, 2018, J CLIN ONCOL, V36, P1714, DOI 10.1200/JCO.2017.77.6385
   Cavaletti G, 2015, CURR OPIN NEUROL, V28, P500, DOI 10.1097/WCO.0000000000000234
   Chavez LM, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112270
   Chen X, 2019, CLIN NEUROPHYSIOL, V130, P1440, DOI 10.1016/j.clinph.2019.03.035
   Chen Y, 2019, GASTROENT RES PRACT, V2019, DOI 10.1155/2019/1759842
   Chon TY, 2013, MAYO CLIN PROC, V88, P1141, DOI 10.1016/j.mayocp.2013.06.009
   Cuzzubbo S, 2017, EUR J CANCER, V73, P1, DOI [10.1016/j.ejca.2016.12:001, 10.1016/j.ejca.2016.12.001]
   Darweesh SKL, 2014, J PERIPHER NERV SYST, V19, P24, DOI 10.1111/jns5.12051
   Doets AY, 2018, BRAIN, V141, P2866, DOI 10.1093/brain/awy232
   Donofrio Peter D, 2017, Continuum (Minneap Minn), V23, P1295, DOI [10.1212/con.0000000000000513, 10.1212/CON.0000000000000513]
   Elgert G, 1999, Am J Acupunct, V27, P15
   Erny D, 2015, NAT NEUROSCI, V18, P965, DOI 10.1038/nn.4030
   Fan Z, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000018619
   Flatters SJL, 2017, BRIT J ANAESTH, V119, P737, DOI 10.1093/bja/aex229
   Garcia CR, 2018, J CLIN ONCOL, V36, DOI 10.1200/JCO.2018.36.5_suppl.37
   Ghaisas S, 2016, PHARMACOL THERAPEUT, V158, P52, DOI 10.1016/j.pharmthera.2015.11.012
   Haanen JBAG, 2017, ANN ONCOL, V28, P119, DOI 10.1093/annonc/mdx225
   Hausheer FH, 2006, SEMIN ONCOL, V33, P15, DOI 10.1053/j.seminoncol.2005.12.010
   Hughes RAC, 2005, LANCET, V366, P1653, DOI 10.1016/S0140-6736(05)67665-9
   ILLA I, 1995, ANN NEUROL, V38, P218, DOI 10.1002/ana.410380214
   Iravani S, 2020, PAIN RES MANAG, V2020, DOI 10.1155/2020/2504674
   Islam Z, 2010, NEUROLOGY, V74, P581, DOI 10.1212/WNL.0b013e3181cff735
   Jang JH, 2020, BRAIN BEHAV IMMUN, V89, P641, DOI 10.1016/j.bbi.2020.08.015
   Janssen JBE, 2021, J IMMUNOTHER, V44, P276, DOI 10.1097/CJI.0000000000000364
   Li HZ, 2019, CLIN INTERV AGING, V14, P1607, DOI 10.2147/CIA.S210751
   Li Y, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/9800488
   Lu LM, 2022, BMJ-BRIT MED J, V376, DOI 10.1136/bmj-2021-067475
   Lu WD, 2013, CURR PAIN HEADACHE R, V17, DOI 10.1007/s11916-013-0321-3
   McGrogan A, 2009, NEUROEPIDEMIOLOGY, V32, P150, DOI 10.1159/000184748
   Mulak A, 2015, WORLD J GASTROENTERO, V21, P10609, DOI 10.3748/wjg.v21.i37.10609
   Okada K, 2021, J NEUROL, V268, P680, DOI 10.1007/s00415-020-10213-x
   Ruts L, 2010, NEUROLOGY, V75, P1439, DOI 10.1212/WNL.0b013e3181f88345
   Ruts L, 2010, NEUROLOGY, V74, P1680, DOI 10.1212/WNL.0b013e3181e07d14
   SCARLATO G, 1991, LANCET, V338, P314, DOI 10.1016/0140-6736(91)90453-V
   Schessl J, 2006, EUR J PEDIATR, V165, P605, DOI 10.1007/s00431-006-0140-1
   SCHONBERGER LB, 1979, AM J EPIDEMIOL, V110, P105, DOI 10.1093/oxfordjournals.aje.a112795
   Sejvar JJ, 2011, NEUROEPIDEMIOLOGY, V36, P123, DOI 10.1159/000324710
   Shahrizaila N, 2021, LANCET, V397, P1214, DOI 10.1016/S0140-6736(21)00517-1
   Shang P, 2021, J NEUROL, V268, P2402, DOI 10.1007/s00415-020-09742-2
   Thompson JA, 2019, J NATL COMPR CANC NE, V17, P255, DOI 10.6004/jnccn.2019.0013
   Torres-Rosas R, 2014, NAT MED, V20, P291, DOI 10.1038/nm.3479
   van den Berg B, 2014, NAT REV NEUROL, V10, P469, DOI 10.1038/nrneurol.2014.121
   Walgaard C, 2011, NEUROLOGY, V76, P968, DOI 10.1212/WNL.0b013e3182104407
   Wang HP, 2020, THORAC CANCER, V11, P191, DOI 10.1111/1759-7714.13240
   Willison HJ, 2016, LANCET, V388, P717, DOI 10.1016/S0140-6736(16)00339-1
   Willison HJ, 2013, TRENDS IMMUNOL, V34, P453, DOI 10.1016/j.it.2013.05.001
   Zhang XY, 2021, BIOSCI TRENDS, V15, P283, DOI 10.5582/bst.2021.01318
NR 49
TC 7
Z9 10
U1 1
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD JUN 2
PY 2022
VL 13
AR 908282
DI 10.3389/fneur.2022.908282
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 2E1JG
UT WOS:000811989200001
PM 35720101
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Cho, HJ
   Jeong, YJ
   Park, KK
   Park, YY
   Chung, IK
   Lee, KG
   Yeo, JH
   Han, SM
   Bae, YS
   Chang, YC
AF Cho, Hyun-Ji
   Jeong, Yun-Jeong
   Park, Kwan-Kyu
   Park, Yoon-Yub
   Chung, Il-Kyung
   Lee, Kwang-Gill
   Yeo, Joo-Hong
   Han, Sang-Mi
   Bae, Young-Seuk
   Chang, Young-Chae
TI Bee venom suppresses PMA-mediated MMP-9 gene activation via JNK/p38 and
   NF-κB-dependent mechanisms
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Bee venom; Phospho-p38; Phospho-JNK; NF-kappa B; MMP-9; MCF-7 cells
ID CELLS IN-VITRO; MATRIX METALLOPROTEINASES; CARCINOMA-CELLS;
   MATRIX-METALLOPROTEINASE-9 EXPRESSION; ACUPUNCTURE POINT;
   DOWN-REGULATION; TUMOR INVASION; MELANOMA-CELLS; CANCER; INHIBITION
AB Ethnopharmacological relevance: Bee venom has been used for the treatment of inflammatory diseases such as rheumatoid arthritis and for the relief of pain in traditional oriental medicine.
   Aim of the study: The purpose of this study is to elucidate the effects of bee venom on MMP-9 expression and determine possible mechanisms by which bee venom relieves or prevents the expression of MMP-9 during invasion and metastasis of breast cancer cells. We examined the expression and activity of MMP-9 and possible signaling pathway affected in PMA-induced MCF-7 cells.
   Material and methods: Bee venom was obtained from the National Institute of Agricultural Science and Technology of Korea. Matrigel invasion assay, wound-healing assay, zymography assay, western blot assay, electrophoretic mobility shift assay and luciferase gene assay were used for assessment.
   Results: Bee venom inhibited cell invasion and migration, and also suppressed MMP-9 activity and expression, processes related to tumor invasion and metastasis, in PMA-induced MCF-7 cells. Bee venom specifically suppressed the phosphorylation of p38/JNK and at the same time, suppressed the protein expression, DNA binding and promoter activity of NF-kappa B. The levels of phosphorylated ERK1/2 and c-Jun did not change. We also investigated MMP-9 inhibition by melittin, apamin and PLA(2), representative single component of bee venom. We confirmed that PMA-induced MMP-9 activity was significantly decreased by melittin, but not by apamin and phospholipase A(2). These data demonstrated that the expression of MMP-9 was abolished by melittin, the main component of bee venom.
   Conclusion: Bee venom inhibits PMA-induced MMP-9 expression and activity by inhibition of NF-kappa B via p38 MAPK and JNK signaling pathways in MCF-7 cells. These results indicate that bee venom can be a potential anti-metastatic and anti-invasive agent. This useful effect may lead to future clinical research on the anti-cancer properties of bee venom. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Cho, Hyun-Ji; Bae, Young-Seuk] Kyungpook Natl Univ, Dept Biochem, Coll Nat Sci, Taegu 702701, South Korea.
   [Cho, Hyun-Ji; Jeong, Yun-Jeong; Park, Kwan-Kyu; Park, Yoon-Yub; Chang, Young-Chae] Catholic Univ Daegu, Sch Med, Res Inst Biomed Engn, Taegu 705718, South Korea.
   [Cho, Hyun-Ji; Jeong, Yun-Jeong; Park, Kwan-Kyu; Park, Yoon-Yub; Chang, Young-Chae] Catholic Univ Daegu, Sch Med, Dept Med, Taegu 705718, South Korea.
   [Chung, Il-Kyung] Catholic Univ Daegu, Dept Biotechnol, Gyongsan 712702, South Korea.
   [Lee, Kwang-Gill; Yeo, Joo-Hong; Han, Sang-Mi] Natl Inst Agr Sci & Technol, Dept Agr Biol, Suwon 441100, Kyunggi Do, South Korea.
C3 Kyungpook National University (KNU); Catholic University of Daegu;
   Catholic University of Daegu; Catholic University of Daegu
RP Bae, YS (corresponding author), Kyungpook Natl Univ, Dept Biochem, Coll Nat Sci, 1370 Sankyuk Dong, Taegu 702701, South Korea.
EM ysbae@knu.ac.kr; ycchang@cu.ac.kr
FU Rural Development Administration, Republic of Korea [20070301-034-001]
FX This work was supported by a grant (Code #: 20070301-034-001) from
   BioGreen 21 Program, Rural Development Administration, Republic of
   Korea.
CR Basset P, 1997, MATRIX BIOL, V15, P535, DOI 10.1016/S0945-053X(97)90028-7
   Bhoopathi P, 2008, J BIOL CHEM, V283, P1545, DOI 10.1074/jbc.M707931200
   Cho HJ, 2007, CARCINOGENESIS, V28, P1104, DOI 10.1093/carcin/bgl217
   Chu ST, 2007, LIFE SCI, V80, P364, DOI 10.1016/j.lfs.2006.09.024
   Chung TW, 2004, FASEB J, V18, P1670, DOI 10.1096/fj.04-2126com
   Eberhardt W, 2000, J IMMUNOL, V165, P5788, DOI 10.4049/jimmunol.165.10.5788
   Gum R, 1997, ONCOGENE, V14, P1481, DOI 10.1038/sj.onc.1200973
   Holle L, 2003, INT J ONCOL, V22, P93
   Hong IK, 2005, EXP MOL MED, V37, P230, DOI 10.1038/emm.2005.31
   Hong S, 2005, J BIOL CHEM, V280, P25202, DOI 10.1074/jbc.M413985200
   Hozumi A, 2001, AM J PHYSIOL-LUNG C, V281, pL1444, DOI 10.1152/ajplung.2001.281.6.L1444
   Itoh T, 1998, CANCER RES, V58, P1048
   Jang HS, 2005, J ETHNOPHARMACOL, V99, P157, DOI 10.1016/j.jep.2005.02.026
   Jang MH, 2003, J PHARMACOL SCI, V91, P95, DOI 10.1254/jphs.91.95
   Johnsen M, 1998, CURR OPIN CELL BIOL, V10, P667, DOI 10.1016/S0955-0674(98)80044-6
   Kato Y, 2002, ONCOL REP, V9, P565
   Kwon YB, 2001, NEUROSCI LETT, V308, P133, DOI 10.1016/S0304-3940(01)01989-9
   Kwon YB, 2001, PAIN, V90, P271, DOI 10.1016/S0304-3959(00)00412-7
   Lee JH, 2001, J VET MED SCI, V63, P251, DOI 10.1292/jvms.63.251
   Lee SO, 2008, BIOCHEM BIOPH RES CO, V366, P1019, DOI 10.1016/j.bbrc.2007.12.068
   Lee YJ, 2007, CHEM-BIOL INTERACT, V169, P189, DOI 10.1016/j.cbi.2007.06.036
   Li B, 2006, ONKOLOGIE, V29, P367, DOI 10.1159/000094711
   Lin CW, 2008, CARCINOGENESIS, V29, P1807, DOI 10.1093/carcin/bgn162
   LIOTTA LA, 1991, CELL, V64, P327, DOI 10.1016/0092-8674(91)90642-C
   Liu X, 2002, J PHARM PHARMACOL, V54, P1083, DOI 10.1211/002235702320266235
   Moon DO, 2006, INT IMMUNOPHARMACOL, V6, P1796, DOI 10.1016/j.intimp.2006.07.027
   Nabeshima K, 2002, PATHOL INT, V52, P255, DOI 10.1046/j.1440-1827.2002.01343.x
   Park HJ, 2004, ARTHRITIS RHEUM-US, V50, P3504, DOI 10.1002/art.20626
   Rahman KMW, 2006, MOL CANCER THER, V5, P2747, DOI 10.1158/1535-7163.MCT-06-0221
   ROUYER N, 1994, INVAS METAST, V14, P269
   Sato T, 2002, CANCER RES, V62, P1025
   Son DJ, 2007, PHARMACOL THERAPEUT, V115, P246, DOI 10.1016/j.pharmthera.2007.04.004
   Sternlicht MD, 2001, ANNU REV CELL DEV BI, V17, P463, DOI 10.1146/annurev.cellbio.17.1.463
   Stone AA, 2000, EXP CELL RES, V254, P110, DOI 10.1006/excr.1999.4731
   Takada Y, 2004, J BIOL CHEM, V279, P15096, DOI 10.1074/jbc.M311192200
   Tu WC, 2008, TOXICON, V52, P318, DOI 10.1016/j.toxicon.2008.06.007
   Weng CJ, 2008, CARCINOGENESIS, V29, P147, DOI 10.1093/carcin/bgm261
   Zeigler ME, 1999, J CELL PHYSIOL, V180, P271
NR 38
TC 54
Z9 57
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD FEB 17
PY 2010
VL 127
IS 3
BP 662
EP 668
DI 10.1016/j.jep.2009.12.007
PG 7
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 569UV
UT WOS:000275628600013
PM 19969058
DA 2026-01-16
ER

PT J
AU Tsaousi, GG
   Pourzitaki, C
   Bilotta, F
AF Tsaousi, Georgia G.
   Pourzitaki, Chryssa
   Bilotta, Federico
TI Prophylaxis of postoperative complications after craniotomy
SO CURRENT OPINION IN ANESTHESIOLOGY
LA English
DT Review
DE craniotomy; postoperative complications; postoperative nausea and
   vomiting; seizures; thromboprophylaxis
ID VENOUS THROMBOEMBOLISM PROPHYLAXIS; BRAIN-TUMOR SURGERY; DOUBLE-BLIND;
   INTRAOPERATIVE DEXMEDETOMIDINE; NAUSEA; MANAGEMENT; PAIN; CHEMOTHERAPY;
   ACUPUNCTURE; ANESTHESIA
AB Purpose of review
   This review reports an update of the evidence on practices applied for the prevention and management of the most common complications after craniotomy surgery.
   Recent findings
   Latest guidelines support the combined thromboprophylaxis with the use of both mechanical and chemical modalities, preferably applied within 24 h after craniotomy. Nevertheless, a heightened risk of minor hemorrhagic events remains an issue of concern. Postoperative nausea and vomiting (PONV) and pain constitute the complications most commonly encountered during the first 24 h postcraniotomy. Recently, neurokinin type-1 receptor antagonists have been tested as adjuncts for PONV prophylaxis with encouraging results, whereas dexmedetomidine and gabapentinoids emerge as promising alternatives for postcraniotomy pain management. The available data for seizure prophylaxis following craniotomy lacks scientific quality; thus, this remains still a debatable issue. Significantly, a growing body of evidence supports the superiority of levetiracetam over the older antiepileptic drugs (AEDs), in terms of efficacy and safety.
   Summary
   Optimum management of postoperative complications is incorporated as an integral part of the augmented quality of care in patients undergoing craniotomy surgery, aiming to improve outcomes. This review may serve as a benchmark for neuroanesthetists for heightened clinical awareness and prompt institution of well-documented practices.
C1 [Tsaousi, Georgia G.] Aristotle Univ Thessaloniki, Sch Med, Dept Anesthesiol & ICU, Maiandrou 32, GR-56224 Thessaloniki, Greece.
   [Pourzitaki, Chryssa] Aristotle Univ Thessaloniki, Sch Med, Dept Pharmacol, Thessaloniki, Greece.
   [Bilotta, Federico] Univ Roma La Sapienza, Dept Anesthesiol, Rome, Italy.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Sapienza University Rome
RP Tsaousi, GG (corresponding author), Aristotle Univ Thessaloniki, Sch Med, Dept Anesthesiol & ICU, Maiandrou 32, GR-56224 Thessaloniki, Greece.
EM tsaousig@otenet.gr
OI Tsaousi, Georgia/0000-0003-3806-837X
CR Alshehri N, 2016, J NEURO-ONCOL, V130, P561, DOI 10.1007/s11060-016-2259-x
   An LX, 2014, AM J CHINESE MED, V42, P1099, DOI 10.1142/S0192415X14500682
   [Anonymous], ANAESTH CRIT CARE PA
   Ansari SF, 2014, J NEURO-ONCOL, V118, P117, DOI 10.1007/s11060-014-1402-9
   Asmussen S, 2017, J NEUROSURG ANESTH, V29, P219, DOI 10.1097/ANA.0000000000000290
   Atsuta J, 2017, J ANESTH, V31, P82, DOI 10.1007/s00540-016-2267-1
   Bergese SD, 2016, FRONT MED-LAUSANNE, V3, DOI 10.3389/fmed.2016.00001
   Bergese SD, 2015, FRONT MED, V2, DOI 10.3389/fmed.2015.00040
   Bergese SD, 2016, FRONT MED-LAUSANNE, V3, DOI 10.3389/fmed.2016.00029
   Bilotta F, 2013, CURR OPIN ANESTHESIO, V26, P517, DOI 10.1097/01.aco.0000432513.92822.c2
   Cote DJ, 2016, J CLIN NEUROSCI, V25, P13, DOI 10.1016/j.jocn.2015.05.053
   Dasenbrock HH, 2015, NEUROSURG FOCUS, V39, DOI 10.3171/2015.10.FOCUS15386
   Gan TJ, 2014, ANESTH ANALG, V118, P85, DOI 10.1213/ANE.0000000000000002
   Gruenbaum SE, 2016, CURR OPIN ANESTHESIO, V29, P552, DOI 10.1097/ACO.0000000000000365
   Gupta Priyanka, 2014, Anesth Essays Res, V8, P72, DOI 10.4103/0259-1162.128914
   Kimmell KT, 2015, J NEUROSURG, V122, P1004, DOI 10.3171/2014.10.JNS14632
   Kong XY, 2015, CLIN NEUROL NEUROSUR, V134, P98, DOI 10.1016/j.clineuro.2015.04.010
   Liu X, 2015, ACUPUNCT MED, V33, P270, DOI 10.1136/acupmed-2014-010749
   Lockney DT, 2017, WORLD NEUROSURG, V98, P28, DOI 10.1016/j.wneu.2016.10.079
   Nyquist P, 2016, NEUROCRIT CARE, V24, P47, DOI 10.1007/s12028-015-0221-y
   Peng K, 2015, CLIN THER, V37, P1114, DOI 10.1016/j.clinthera.2015.02.011
   Peng YM, 2016, J NEUROSURG ANESTH, V28, P309, DOI 10.1097/ANA.0000000000000230
   Pergolizzi JV, 2012, J CLIN ANESTH, V24, P334, DOI 10.1016/j.jclinane.2011.07.019
   Pourzitaki C, 2016, BRIT J CLIN PHARMACO, V82, P315, DOI 10.1111/bcp.12926
   Rajan S, 2016, J NEUROSURG ANESTH, V28, P282, DOI 10.1097/ANA.0000000000000221
   Rapoport BL, 2010, SUPPORT CARE CANCER, V18, P423, DOI 10.1007/s00520-009-0680-9
   Riva M, 2005, NEUROL SCI, V26, pS40, DOI 10.1007/s10072-005-0404-y
   Ryu JH, 2014, BMC ANESTHESIOL, V14, DOI 10.1186/1471-2253-14-63
   Rocha PAS, 2015, HEADACHE, V55, P733, DOI 10.1111/head.12563
   Sayegh ET, 2014, J NEUROSURG, V121, P1139, DOI 10.3171/2014.7.JNS132829
   Shimony N, 2016, J NEUROSURG, V125, P1513, DOI 10.3171/2015.10.JNS151516
   Sjåvik K, 2016, WORLD NEUROSURG, V88, P320, DOI 10.1016/j.wneu.2015.12.077
   Song J, 2016, J NEUROSURG ANESTH, V28, P14, DOI 10.1097/ANA.0000000000000190
   Titsworth WL, 2016, J NEUROSURG, V125, P1523, DOI 10.3171/2015.10.JNS15698
   Tricco AC, 2015, BMC PHARMACOL TOXICO, V16, DOI 10.1186/2050-6511-16-1
   Tsaousi G., 2016, Pain Practice, P1
   Vadivelu N, 2016, J PAIN RES, V9, P37, DOI 10.2147/JPR.S85782
   Weston J, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007286.pub3
   Yang Y, 2015, J CLIN NEUROSCI, V22, P1227, DOI 10.1016/j.jocn.2015.01.025
NR 39
TC 9
Z9 14
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0952-7907
EI 1473-6500
J9 CURR OPIN ANESTHESIO
JI Curr. Opin. Anesthesiol.
PD OCT
PY 2017
VL 30
IS 5
BP 534
EP 539
DI 10.1097/ACO.0000000000000493
PG 6
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA FJ5MG
UT WOS:000412795000003
PM 28692438
DA 2026-01-16
ER

PT J
AU Lee, YS
   Wie, C
   Pew, S
   Kling, JM
AF Lee, Yeonsoo Sara
   Wie, Christopher
   Pew, Scott
   Kling, Juliana M.
TI Stellate ganglion block as a treatment for vasomotor symptoms: Clinical
   application
SO CLEVELAND CLINIC JOURNAL OF MEDICINE
LA English
DT Review
ID BREAST-CANCER SURVIVORS; REGIONAL PAIN SYNDROME; HOT FLASHES; TREATMENT
   OPTIONS; UNIFYING THEORY; MANAGEMENT; MENOPAUSAL; ACUPUNCTURE; DURATION;
   FLUSHES
AB Vasomotor symptoms, also called hot flashes, hot flushes, and night sweats, are common during the menopause transition. Severe symptoms can substantially decrease quality of life. The authors first review current hormonal and nonhormonal therapies, then review evidence supporting the potential use of stellate ganglion block for managing vasomotor symptoms in perimenopausal and women.
C1 [Lee, Yeonsoo Sara; Kling, Juliana M.] Mayo Clin, Alix Sch Med, Scottsdale, AZ 85260 USA.
   [Wie, Christopher; Pew, Scott] Mayo Clin, Dept Anesthesiol & Perioperat Med, Anesthesiol, Phoenix, AZ USA.
   [Kling, Juliana M.] Mayo Clin, Div Womens Hlth Internal Med, 13737 North 92nd St, Scottsdale, AZ 85260 USA.
   [Kling, Juliana M.] Mayo Clin, Dept Med, Equ Inclus & Divers, Scottsdale, AZ 85260 USA.
C3 Mayo Clinic; Mayo Clinic Phoenix; Mayo Clinic; Mayo Clinic Phoenix; Mayo
   Clinic; Mayo Clinic Phoenix; Mayo Clinic; Mayo Clinic Phoenix
RP Kling, JM (corresponding author), Mayo Clin, Div Womens Hlth Internal Med, 13737 North 92nd St, Scottsdale, AZ 85260 USA.
EM kling.juliana@mayo.edu
CR Academic Committee of the Korean Society of Menopause, 2020, J Menopausal Med, V26, P69, DOI [10.6118/jmm.20000, 10.6118/jmm.20000]
   Alino J, 2011, MED HYPOTHESES, V77, P465, DOI 10.1016/j.mehy.2011.06.038
   Assaf AR, 2017, AM HEALTH DRUG BENEF, V10, P311
   Avis NE, 2008, MENOPAUSE, V15, P1070, DOI 10.1097/gme.0b013e31816d5b03
   Avis NE, 2015, JAMA INTERN MED, V175, P531, DOI 10.1001/jamainternmed.2014.8063
   Blümel JE, 2011, MENOPAUSE, V18, P778, DOI 10.1097/gme.0b013e318207851d
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1002/smll.202408771
   Carpenter J, 2015, MENOPAUSE, V22, P1155, DOI 10.1097/GME.0000000000000546
   ClinicalTrials.gov, SEARCH MEN HOT FLASH
   Daley A, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006108.pub2
   Dampier C., 2019, Chicago Tribune
   David PS, 2018, MENOPAUSE, V25, P1105, DOI 10.1097/GME.0000000000001126
   El Khoudary SR, 2019, MENOPAUSE, V26, P1213, DOI 10.1097/GME.0000000000001424
   Ferrillo MG, 2016, CLIN CASE REP, V4, P861, DOI 10.1002/ccr3.614
   Freeman EW, 2014, MENOPAUSE, V21, P924, DOI [10.1097/gme.0000000000000196, 10.1097/GME.0000000000000196]
   Guttuso T, 2013, MATURITAS, V76, P221, DOI 10.1016/j.maturitas.2013.08.001
   Haest K, 2012, ANN ONCOL, V23, P1449, DOI 10.1093/annonc/mdr478
   Leon-Ferre RA, 2020, JNCI CANCER SPECT, V4, DOI 10.1093/jncics/pkz088
   Lipov E, 2005, J WOMENS HEALTH, V14, P737, DOI 10.1089/jwh.2005.14.737
   Lipov EG, 2008, LANCET ONCOL, V9, P523, DOI 10.1016/S1470-2045(08)70131-1
   Lipov EG, 2012, MIL MED, V177, P125, DOI 10.7205/MILMED-D-11-00328
   Lipov EG, 2009, MED HYPOTHESES, V72, P657, DOI 10.1016/j.mehy.2009.01.009
   Maclennan A H, 2004, Cochrane Database Syst Rev, pCD002978, DOI 10.1002/14651858.CD002978.pub2
   Munakomi S., 2021, STATPEARLS
   North Amer Menopause Soc, 2018, MENOPAUSE, V25, P1362, DOI 10.1097/GME.0000000000001241
   Othman AH, 2014, PAIN MED, V15, P410, DOI 10.1111/pme.12331
   Pachman DR, 2011, SUPPORT CARE CANCER, V19, P941, DOI 10.1007/s00520-010-0907-9
   Pachman DR, 2010, INT J WOMENS HEALTH, V2, P123
   Pandya KJ, 2005, LANCET, V366, P818, DOI 10.1016/S0140-6736(05)67215-7
   Pandya KJ, 2000, ANN INTERN MED, V132, P788, DOI 10.7326/0003-4819-132-10-200005160-00004
   Peterson K, 2017, VA EVIDENCE SYNTHESI
   Prague JK, 2018, MENOPAUSE, V25, P862, DOI 10.1097/GME.0000000000001090
   Rahimzadeh P, 2018, CANCER MANAG RES, V10, P4831, DOI 10.2147/CMAR.S173511
   Sarrel P, 2015, MENOPAUSE, V22, P260, DOI [10.1097/gme.0000000000000320, 10.1097/GME.0000000000000320]
   Sloan JA, 2001, J CLIN ONCOL, V19, P4280, DOI 10.1200/JCO.2001.19.23.4280
   Stubbs Chris, 2017, J Okla State Med Assoc, V110, P272
   Thacker HL, 2011, J WOMENS HEALTH, V20, P1007, DOI 10.1089/jwh.2010.2403
   Thurston RC, 2011, OBSTET GYN CLIN N AM, V38, P489, DOI 10.1016/j.ogc.2011.05.006
   Uchida K, 2002, MED HYPOTHESES, V59, P446, DOI 10.1016/S0306-9877(02)00158-5
   Umland EM, 2012, INT J WOMENS HEALTH, V4, P305, DOI 10.2147/IJWH.S24614
   van Gastel P, 2013, CLIMACTERIC, V16, P41, DOI 10.3109/13697137.2012.709889
   Walega DR, 2014, MENOPAUSE, V21, P807, DOI [10.1097/gme.0000000000000194, 10.1097/GME.0000000000000194]
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   Westerhaus MJ, 2001, BRAIN RES, V903, P117, DOI 10.1016/S0006-8993(01)02453-2
NR 44
TC 22
Z9 24
U1 1
U2 15
PU CLEVELAND CLINIC
PI CLEVELAND
PA 9500 EUCLID AVE, CLEVELAND, OH 44106 USA
SN 0891-1150
EI 1939-2869
J9 CLEV CLIN J MED
JI Clevel. Clin. J. Med.
PD MAR
PY 2022
VL 89
IS 3
BP 147
EP 153
DI 10.3949/ccjm.89a.21032
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0O8CW
UT WOS:000783752300006
PM 35232827
OA gold
DA 2026-01-16
ER

PT J
AU de la Calle, JL
   De Andres, J
   Pérez, M
   López, V
AF de la Calle, Jose-Luis
   De Andres, Jose
   Perez, Maria
   Lopez, Vanessa
TI Add-On Treatment with Pregabalin for Patients with Uncontrolled
   Neuropathic Pain Who Have Been Referred to Pain Clinics
SO CLINICAL DRUG INVESTIGATION
LA English
DT Article
ID DIABETIC PERIPHERAL NEUROPATHY; USUAL CARE; HOSPITAL ANXIETY;
   COST-UTILITY; QUESTIONNAIRE; VALIDATION; MANAGEMENT; INDIVIDUALS;
   COMBINATION; COMMUNITY
AB Objective The aim of this study was to investigate the impact of pregabalin on pain, other symptoms, and patient-reported outcomes for patients with uncontrolled pain who have been referred to pain clinics.
   Patients and Methods Adult patients with uncontrolled pain who had a score of >= 4 in the DN4 questionnaire were evaluated at baseline, month 3, and month 6. Evaluations included pain levels using a visual analog (VAS) scale as well as anxiety, depression, sleep, disability, and treatment satisfaction employing validated tools.
   Results Our sample comprised 413 patients who met the selection criteria, had not received pregabalin previously, and were prescribed pregabalin at the study initiation, mainly (97 %) as add-on therapy. Overall, patients had a statistically significant reduction in VAS pain score of 41 points (54 % reduction, p < 0.001), varying from 64 % reduction (oncological pain) to 31 % reduction (central neuropathic pain). Effect sizes for anxiety, depression, sleep, and treatment satisfaction improvement were moderate to large depending on the dimension and clinical entity.
   Conclusion Our results suggest that in patients with uncontrolled neuropathic pain of various origins who were treated at pain clinics, the addition of pregabalin to a wider pharmacological treatment regimen was associated with a clinically relevant improvement of pain and psychological well-being and a reduction in the impact of neuropathic pain on daily activities. Add-on treatment with pregabalin was well tolerated.
C1 [de la Calle, Jose-Luis] Hop Ramon y Cajal, Pain Unit, Madrid, Spain.
   [De Andres, Jose] Univ Valencia, Gen Hosp, Sch Med, Anesthesia Crit Care & Multidisciplinary Pain Man, Valencia, Spain.
   [Perez, Maria; Lopez, Vanessa] Pfizer Espana, Med Unit, Madrid 28108, Spain.
C3 University of Valencia; Pfizer; Pfizer Spain
RP Pérez, M (corresponding author), Pfizer Espana, Med Unit, Avda Europa,20 B,Parque Empresarial La Moraleja, Madrid 28108, Spain.
EM maria.perez2@pfizer.com
RI De Andres, Jose/AAG-3413-2019
FU Pfizer, S.L.U.
FX The authors thank Fernando Rico-Villademoros from COCIENTE S.L. for his
   assistance in the preparation of the draft of this manuscript; this
   assistance was funded by Pfizer, S.L.U.
CR Achar A, 2010, INDIAN J DERMATOL VE, V76, P63, DOI 10.4103/0378-6323.58686
   Bouhassira D, 2005, PAIN, V114, P29, DOI 10.1016/j.pain.2004.12.010
   Bouhassira D, 2004, PAIN, V108, P248, DOI 10.1016/j.pain.2003.12.024
   Cardenas DD, 2013, NEUROLOGY, V80, P533, DOI 10.1212/WNL.0b013e318281546b
   Carter G T, 2001, Phys Med Rehabil Clin N Am, V12, P447
   de Andrés J, 2014, PAIN RES TREAT, V2014, DOI 10.1155/2014/518716
   de Salas-Cansado M, 2012, PRIM CARE DIABETES, V6, P303, DOI 10.1016/j.pcd.2012.03.001
   de Salas-Cansado M, 2012, PAIN MED, V13, P699, DOI 10.1111/j.1526-4637.2012.01375.x
   Dworkin RH, 2010, MAYO CLIN PROC, V85, pS3, DOI 10.4065/mcp.2009.0649
   Flórez-García M, 2011, PAIN PRACT, V11, P369, DOI 10.1111/j.1533-2500.2010.00430.x
   Gordon Jason, 2012, J Med Econ, V15, P207, DOI 10.3111/13696998.2011.632797
   Gore M, 2006, J PAIN, V7, P892, DOI 10.1016/j.jpain.2006.04.013
   Harden N, 2003, J PAIN SYMPTOM MANAG, V25, pS12, DOI 10.1016/S0885-3924(03)00065-4
   Hays R.D., 1992, MEASURING FUNCTIONIN, P235
   Herrero MJ, 2003, GEN HOSP PSYCHIAT, V25, P277, DOI 10.1016/S0163-8343(03)00043-4
   KAZIS LE, 1989, MED CARE, V27, pS178, DOI 10.1097/00005650-198903001-00015
   Lampl C, 2010, J NEUROL, V257, P1265, DOI 10.1007/s00415-010-5504-9
   Luciano JV, 2010, J AFFECT DISORDERS, V121, P52, DOI 10.1016/j.jad.2009.05.008
   McDermott AM, 2006, EUR J PAIN, V10, P127, DOI 10.1016/j.ejpain.2005.01.014
   Morera-Domínguez C, 2010, CLIN DRUG INVEST, V30, P517, DOI 10.2165/11536280-000000000-00000
   National Institute for Health and Clinical Excellence, 2010, NEURP PAIN PHARM MAN
   Navarro A, 2012, PAIN PRACT, V12, P382, DOI 10.1111/j.1533-2500.2011.00515.x
   Perez C, 2011, Clin Med Rev Ther, V11, P325
   Pérez C, 2009, CLIN DRUG INVEST, V29, P441, DOI 10.2165/00044011-200929070-00002
   Perez C, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-66
   Plested M, 2010, BMC NEUROL, V10, DOI 10.1186/1471-2377-10-116
   Prettyjohns Matthew, 2012, J Med Econ, V15, P1097, DOI 10.3111/13696998.2012.704458
   Rehm S, 2010, CURR MED RES OPIN, V26, P1607, DOI 10.1185/03007995.2010.483675
   Rejas J, 2007, EUR J PAIN, V11, P329, DOI 10.1016/j.ejpain.2006.05.002
   Rejas J, 2011, BMC MED RES METHODOL, V11, DOI 10.1186/1471-2288-11-142
   Romanò CL, 2009, J ORTHOP TRAUMATOL, V10, P185, DOI 10.1007/s10195-009-0077-z
   Ruiz MA, 2008, VALUE HEALTH, V11, P913, DOI 10.1111/j.1524-4733.2008.00323.x
   Saldaña MT, 2012, CLIN DRUG INVEST, V32, P401, DOI 10.2165/11599400-000000000-00000
   Smith BH, 2012, BMC NEUROL, V12, DOI 10.1186/1471-2377-12-29
   Stacey BR, 2008, PAIN MED, V9, P1202, DOI 10.1111/j.1526-4637.2008.00423.x
   Taylor Rod S, 2006, Pain Pract, V6, P22, DOI 10.1111/j.1533-2500.2006.00054.x
   Tolle Thomas, 2006, Pain Pract, V6, P153, DOI 10.1111/j.1533-2500.2006.00079.x
   Torrance N, 2013, PAIN, V154, P690, DOI 10.1016/j.pain.2012.12.022
   Vázquez-Barquero JL, 2000, ACTAS ESP PSIQUIATRI, V28, P77
   Woolf CJ, 1999, LANCET, V353, P1959, DOI 10.1016/S0140-6736(99)01307-0
   World Health Organization, 2004, WHO DIS ASS SCHED 2
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
   Zin CS, 2010, J PAIN, V11, P462, DOI 10.1016/j.jpain.2009.09.003
NR 43
TC 6
Z9 6
U1 0
U2 5
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1173-2563
EI 1179-1918
J9 CLIN DRUG INVEST
JI Clin. Drug Invest.
PD DEC
PY 2014
VL 34
IS 12
BP 833
EP 844
DI 10.1007/s40261-014-0239-5
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AU1NR
UT WOS:000345388000001
PM 25421816
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Chan, AL
   Nasr, R
   Arcos, D
   Kagramanov, D
   Asuzu, C
   Bao, T
   Cheung, YT
   Kwon, JH
   Lacey, J
   Lee, RT
   Lustberg, M
   Ohaeri, BM
   Rao, ST
   Soto-Perez-de-Celis, E
   Witt, CM
   Lopez, AM
AF Chan, Alexandre
   Nasr, Reem
   Arcos, Daniela
   Kagramanov, Dalia
   Asuzu, Chioma
   Bao, Ting
   Cheung, Yin Ting
   Kwon, Jung Hye
   Lacey, Judith
   Lee, Richard T.
   Lustberg, Maryam
   Ohaeri, Beatrice M.
   Rao, Santosh
   Soto-Perez-de-Celis, Enrique
   Witt, Claudia M.
   Lopez, Ana Maria
TI Evaluation of integrative oncology modalities for symptom management: a
   MASCC/SIO global survey
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Integrative oncology; Cancer supportive care; Oncology; Cancer; Global
   perspectives
ID MEDICINE; EDUCATION; CARE
AB BackgroundWith growing evidence pointing towards the potential of integrative oncology modalities (IOM) in addressing cancer and cancer-treatment related symptoms, research on IOM utilization and implementation is warranted. This study examines global stakeholder perspectives on integrative oncology (IO) utilization for supportive cancer care.MethodsMembers of the Multinational Association of Supportive Care in Cancer (MASCC) and the Society for Integrative Oncology (SIO) completed a survey on the utilization of IOM for supportive cancer care. Descriptive statistics were used to assess demographic data, IOM usage patterns, IOM education, and financial considerations for utilizing IOM.ResultsAmong 344 participants representing eight geographical regions, 70% reported having utilized or recommended IOM and 79% perceived IOM to be underutilized in cancer supportive care. Acupuncture (48%), exercise classes (39%), nutrition (38%), breathing/yoga (38%) and personalized exercise (38%) were among the most utilized IOM across regions. Relatedly, the symptoms for which IOM were most recommended for persons with a diagnosis of cancer in active treatment [AT] or completed treatment [CT] respectively were emotional (AT 23%; CT 26%), pain (AT 22%; CT 20%), gastrointestinal (AT 21%; CT 12%) and fatigue (AT 15%; CT 16%). The perceived availability of integrative medicine training was highest in North America (69%). Across regions, self-pay (20%-67%), private insurance (0%-26%) and government insurance (7%-40%) were the most common forms of payment for IOM. The IOM most recommended in high-income countries (acupuncture, exercise, massage, individual exercise) varied from the IOM most recommended in low-middle income countries (nutrition counseling, exercise classes, breathing, acupuncture).ConclusionThis study provides valuable insights into global utilization patterns of IOM in supportive cancer care, highlighting that while most respondents have utilized IOM, there is a perceived underutilization overall. Our results show significant regional differences in the availability of integrative oncology education and hint to financial barriers impacting IOM use. Further research is necessary to explore these aspects and inform strategies for supporting IOM implementation efforts.
C1 [Chan, Alexandre; Nasr, Reem; Arcos, Daniela; Kagramanov, Dalia] Univ Calif Irvine, Dept Clin Pharm Practice, 802 W Peltason Dr, Irvine, CA 92697 USA.
   [Asuzu, Chioma] Univ Ibadan, Dept Guidance & Counselling, Ibadan, Nigeria.
   [Bao, Ting] Dana Farber Canc Inst, Zakim Ctr Integrat Therapies & Hlth Living, Boston, MA USA.
   [Cheung, Yin Ting] Chinese Univ Hong Kong, Fac Med, Sch Pharm, Shatin, Hong Kong, Peoples R China.
   [Kwon, Jung Hye] Chung Ang Univ, Coll Med, Div Hemato oncol, Anseong, Gyeonggi Do, South Korea.
   [Lacey, Judith] Chris OBrien Lifehouse Comprehens Canc Ctr, Dept Support Care & Integrat Oncol, Sydney, NSW, Australia.
   [Lee, Richard T.] City Hope Comprehens Canc Ctr, Cherng Family Ctr Integrat Oncol, Duarte, CA USA.
   [Lustberg, Maryam] Yale Univ, Smilow Canc Hosp, Breast Canc Ctr, New Haven, CT USA.
   [Ohaeri, Beatrice M.] Univ Ibadan, Coll Med, Ibadan, Nigeria.
   [Rao, Santosh] Univ Hosp Seidman Canc Ctr, Cleveland, OH USA.
   [Soto-Perez-de-Celis, Enrique] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Geriatr, Mexico City, Mexico.
   [Soto-Perez-de-Celis, Enrique] Univ Colorado, UC Hlth Diane OConnor Thompson Breast Ctr, Auschutz Med Campus, Aurora, CO USA.
   [Witt, Claudia M.] Univ Hosp Zurich, Inst Complementary & Integrat Med, Zurich, Switzerland.
   [Lopez, Ana Maria] Thomas Jefferson Univ, Sidney Kimmel Comprehens Canc Ctr, Philadelphia, PA USA.
C3 University of California System; University of California Irvine;
   University of Ibadan; Harvard University; Harvard University Medical
   Affiliates; Dana-Farber Cancer Institute; Chinese University of Hong
   Kong; Chung Ang University; Chung Ang University Hospital; Chris O'Brien
   Lifehouse; City of Hope; Yale University; University of Ibadan;
   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; University of Colorado System; University of Colorado Anschutz
   Medical Campus; University of Zurich; University Zurich Hospital; Thomas
   Jefferson University
RP Chan, AL (corresponding author), Univ Calif Irvine, Dept Clin Pharm Practice, 802 W Peltason Dr, Irvine, CA 92697 USA.
EM a.chan@uci.edu
RI Cheung, Yin Ting/AAT-4384-2021; Lacey, Judith/AAI-5754-2021; Witt,
   Claudia/AAX-2370-2021; Soto-Perez-de-Celis, Enrique/U-5357-2017; Asuzu,
   Chioma/I-2625-2019
CR [Anonymous], National Comprehensive Cancer Networkwww
   Armstrong K, 2018, SUPPORT CARE CANCER, V26, P2267, DOI 10.1007/s00520-017-4007-y
   Bower JE, 2024, J CLIN ONCOL, V42, DOI 10.1200/JCO.24.00541
   Carlson LE, 2023, J CLIN ONCOL, V41, P4562, DOI 10.1200/JCO.23.00857
   Chan A, 2024, CANCER MED-US, V13, DOI 10.1002/cam4.70234
   Dans M, 2021, J NATL COMPR CANC NE, V19, P780, DOI 10.6004/jnccn.2021.0033
   ESMO, 2024, Clinical Practice Guidelines
   Garchinski CM, 2014, FUTURE ONCOL, V10, P2603, DOI 10.2217/fon.14.186
   Gonzalez M, 2021, PSYCHO-ONCOLOGY, V30, P1196, DOI 10.1002/pon.5671
   Grant SJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735418823266
   Karim S, 2021, CURR ONCOL, V28, P853, DOI 10.3390/curroncol28010084
   Kim JEE, 2009, J PAIN SYMPTOM MANAG, V37, P715, DOI 10.1016/j.jpainsymman.2008.04.018
   Latte-Naor S, 2019, J ONCOL PRACT, V15, P7, DOI 10.1200/JOP.18.00554
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   Misiag W, 2022, CANCERS, V14, DOI 10.3390/cancers14174154
   Mumber MP, 2016, J CLIN ONCOL, V34, DOI 10.1200/jco.2016.34.26_suppl.171
   Ng JY, 2024, SUPPORT CARE CANCER, V32, DOI 10.1007/s00520-024-08785-9
   Ngamkham S, 2019, ASIA-PAC J ONCOL NUR, V6, P161, DOI 10.4103/apjon.apjon_67_18
   Semeniuk G, 2023, J CLIN MED, V12, DOI 10.3390/jcm12123946
   Society for Integrative Oncology, 2024, Training Modules
   Toledano A, 2021, INTEGR CANCER THER, V20, DOI 10.1177/15347354211004730
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
NR 24
TC 0
Z9 1
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD NOV 3
PY 2025
VL 25
IS 1
AR 406
DI 10.1186/s12906-025-05157-6
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 9HW1B
UT WOS:001606725000001
PM 41184943
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Browne, N
   Bush, P
   Cabo, F
AF Browne, Neil
   Bush, Philippa
   Cabo, Fernando
TI Relieving pressure - An evaluation of Shiatsu treatments for cancer &
   palliative care patients in an NHS setting
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Shiatsu; Bodywork; Cancer; MYCaW; NHS; Palliative care
ID WELL-BEING MYCAW; COMPLEMENTARY THERAPIES; SUPPORT CARE; INTEGRATIVE
   ONCOLOGY; YOURSELF CONCERNS; ACUPRESSURE; MEDICINE; PAIN; QUESTIONNAIRE;
   EXPERIENCES
AB Introduction: The study investigated the effectiveness of Shiatsu therapy in relation to the management of health and wellbeing concerns of cancer and palliative care patients in an out-patient clinic.
   Method: Patients are referred to the Complementary Therapies Service for symptom management, particularly stress and anxiety, but also other symptoms such as nausea or insomnia. Data was collected following use of the Measure Yourself Concerns and Wellbeing (MYCaW) questionnaire, which was designed for evaluating supportive care interventions.
   Results: Mean changes in post-intervention MYCaW scores were highly significant (p < 0.001), demonstrating considerable improvements in both presenting symptoms and perceptions of wellbeing. Based on a significance level of 0.05, both the Wilcoxon signed-ranks test and the two-tailed t-test indicated that post-treatment ranks and means were statistically significantly lower than pre-treatment ranks and means in the categories.
   Conclusion: Anxiety, stress management and pain scores were the most improved. Wellbeing scores also improved, on average, by two points on the Likert scale. Patients stated that 'being listened to' and 'being heard' were important factors when describing how Shiatsu had helped.
   We suggest that a study using larger numbers is necessary in order to provide more robust evidence rather than emerging trends.
C1 [Browne, Neil; Bush, Philippa; Cabo, Fernando] Whipps Cross Univ Hosp, Margaret Ctr, Barts Hlth NHS Trust, London E11 1NR, England.
C3 Barts Health NHS Trust; Whipps Cross University Hospital
RP Browne, N (corresponding author), Whipps Cross Univ Hosp, Margaret Ctr, Barts Hlth NHS Trust, London E11 1NR, England.
EM neil.browne@bartshealth.nhs.uk; Fernando.Cabo@marywardcentre.ac.uk
OI Cabo, Fernando/0000-0002-7529-3755
CR Adams Glyn, 2002, Anthropol Med, V9, P245, DOI 10.1080/13648470216334
   Adams Mariama, 2007, Int Semin Surg Oncol, V4, P10, DOI 10.1186/1477-7800-4-10
   Anderson JG, 2012, J ALTERN COMPLEM MED, V18, P235, DOI 10.1089/acm.2011.0022
   [Anonymous], 2003, QUEST COMPL MYMOP FR
   [Anonymous], 2014, QUAL AN GUID MYCAW
   [Anonymous], DIFF AUD SERV EV RES
   Argash Oz, 2008, Harefuah, V147, P707
   Boon Heather S, 2007, BMC Womens Health, V7, P4, DOI 10.1186/1472-6874-7-4
   Briscoe Julia, 2013, Nurs Times, V109, P18
   Cabo Fernando, 2018, Int J Ther Massage Bodywork, V11, P4, DOI 10.3822/ijtmb.v11i2.391
   Calisar Tzvika, FOUNDER SEIKI MERIDI
   Cartwright T, 2007, SOC SCI MED, V64, P1692, DOI 10.1016/j.socscimed.2006.11.034
   Cassileth BR, 2010, ONCOLOGIST, V15, P19, DOI 10.1634/theoncologist.2009-S504
   Cheesman S, 2001, Int J Palliat Nurs, V7, P234
   Complementary and Natural Health Council (UK), 2017, COR CURR SHIATS INTR, P3
   de Winter J.C. F., 2010, PRACTICAL ASSESSMENT, V15, P1, DOI [DOI 10.7275/BJ1P-TS64, 10.7275/bj1p-ts64]
   Elliott Emma, 2014, Br J Nurs, V23, P808, DOI 10.12968/bjon.2014.23.14.805
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
   Ferguson P., 2015, SHIATSU SOC J    SPR, P28
   Frenkel M, 2010, INTEGR CANCER THER, V9, P276, DOI 10.1177/1534735410378663
   Gardani G, 2007, Minerva Med, V98, P665
   Harrington J E, 2012, Complement Ther Clin Pract, V18, P10, DOI 10.1016/j.ctcp.2011.05.002
   Jikidenkai Shiatsu Professionals Association of British Columbia, 2018, SHIATS DEF SHIATS
   Jolliffe R, 2015, INTEGR CANCER THER, V14, P26, DOI 10.1177/1534735414555809
   JUNIPER EF, 1994, J CLIN EPIDEMIOL, V47, P81, DOI 10.1016/0895-4356(94)90036-1
   Lai YH, 2004, SUPPORT CARE CANCER, V12, P645, DOI 10.1007/s00520-004-0626-1
   Lida M., 2000, KITAKANTO MED J, V50, P227
   London Cancer, 2018, LOND HOL NEEDS ASS
   Long AF, 2008, J ALTERN COMPLEM MED, V14, P921, DOI 10.1089/acm.2008.0085
   Molassiotis A, 2005, ANN ONCOL, V16, P655, DOI 10.1093/annonc/mdi110
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P3, DOI 10.1016/j.ctim.2006.07.005
   Paterson C, 2007, COMPLEMENT THER MED, V15, P38, DOI 10.1016/j.ctim.2006.03.006
   Peace G, 2002, COMPLEMENT THER MED, V10, P33, DOI 10.1054/ctim.2002.0500
   Penny Brohn UK., 2016, LIVING WELL CANC, P1
   Polley MJ, 2007, SUPPORT CARE CANCER, V15, P963, DOI 10.1007/s00520-007-0283-2
   Robinson N, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-88
   Rosser B., 2011, FUNDAMENTALS BIOSTAT
   Running A, 2012, CURR PAIN HEADACHE R, V16, P325, DOI 10.1007/s11916-012-0275-x
   Seers HE, 2009, SUPPORT CARE CANCER, V17, P1159, DOI 10.1007/s00520-008-0565-3
   Serizawa K., 1957, SHIATSU RIRON JITSUG
   Shin YH, 2004, CANCER NURS, V27, P267, DOI 10.1097/00002820-200407000-00002
   Thorne S, 2002, INT J NURS STUD, V39, P671, DOI 10.1016/S0020-7489(02)00005-6
   Twycross Alison, 2014, Evid Based Nurs, V17, P65, DOI 10.1136/eb-2014-101871
   Villani V, 2017, NEUROL SCI, V38, P999, DOI 10.1007/s10072-017-2888-7
   Ward S., 2004, Economic Review
   Wesa K, 2008, HEMATOL ONCOL CLIN N, V22, P343, DOI 10.1016/j.hoc.2008.02.002
   Yuan SLK, 2013, J MANIP PHYSIOL THER, V36, P436, DOI 10.1016/j.jmpt.2013.05.019
NR 47
TC 3
Z9 3
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD AUG
PY 2018
VL 21
BP 27
EP 33
DI 10.1016/j.eujim.2018.06.002
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA GS5UR
UT WOS:000443737400005
DA 2026-01-16
ER

PT J
AU Wang, JX
   Chen, YF
   Zhai, X
   Chu, YP
   Liu, XD
   Ma, XL
AF Wang, Junxin
   Chen, Yufeng
   Zhai, Xing
   Chu, Yupeng
   Liu, Xiangdi
   Ma, Xueling
TI Visualizing Research Trends and Identifying Hotspots of Traditional
   Chinese Medicine (TCM) Nursing Technology for Insomnia: A 18-Years
   Bibliometric Analysis of Web of Science Core Collection
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE insomnia; TCM; nursing; technique; visualization analysis; bibliometric
ID AURICULAR POINT ACUPRESSURE; RANDOMIZED CONTROLLED-TRIAL; SLEEP QUALITY;
   BREAST-CANCER; AROMATHERAPY; DEPRESSION; PATTERNS; ANXIETY; RISK;
   ASSOCIATION
AB ObjectiveTo explore the research hotspot and frontier direction of TCM nursing of insomnia and provide reference for the follow-up study of the optimal scheme of TCM nursing of insomnia. BackgroundInsomnia is a common sleep-wake disorder, affects 6-10% of adults and was associated with independent higher risks of cardiovascular disease and diabetes. TCM Nursing Techniques of insomnia has a long history and has shown a definite impact. However, it's still lack of analysis in the field of the most commonly used and effective techniques, as well as the co-morbidities associated with insomnia. Therefore, the database was searched and analyzed to find effective TCM Nursing Techniques for insomnia and related diseases related to insomnia. MethodRandomized controlled trials on the intervention of TCM Nursing Techniques in insomnia were retrieved from Web of Science Core Collection and imported into CiteSpace 5.6.R5 visualization software. The works of literature were co-cited by keywords authors and institutions for visual analysis, and the co-morbidities associated with insomnia of TCM Nursing Techniques in literature was extracted manually. The symptoms of co-morbidities associated with insomnia were imported into Cytoscape 3.9.0 software and clustered by CytoHubba. ResultAs of October 20, 2021, the literature published in the last 20 years from Web of Science Core Collection was screened, and the publication period of the included literature was from 2004 to 2021. From 2016 to now, the total number of articles has been increasing. A total of 146 articles were included, and the highest production year was 2020. There is little cooperation between states, institutions, and authors. China (including Hong Kong and Taiwan) and Hong Kong Polytech University are leading countries and institutions in this area. MYUNGHAENG HUR is the most cited author, and J ALTERN COMPLEM MED is the most cited journal. According to cluster analysis and keyword frequency, auricular therapy, aromatherapy, and acupressure are the three most commonly used techniques. While the top five co-morbidities are fatigue, anxiety, depression, pain and hemodialysis. The three frontier topics and the main research directions are sleep quality, comorbid insomnia and clinical trial design. ConclusionWe found that acupressure, aromatherapy, and auricular acupoint therapy are the most commonly used nursing methods of TCM to intervene in insomnia. However, these studies have limitations such as small sample size, lack of objectivity in evaluating sleep quality, and high heterogeneity of intervention measures, which are not conducive to forming TCM clinical nursing guidelines. Therefore, it is necessary to adopt objectified sleep quality evaluation methods, select suitable acupoints according to TCM theories, and design multi-center large-sample clinical trials based on the safety principle of randomized blind control. This study provides an in-depth perspective for insomnia research on TCM Nursing Techniques and includes information for follow-up research on TCM Nursing Techniques of insomnia.
C1 [Wang, Junxin; Liu, Xiangdi; Ma, Xueling] Beijing Univ Chinese Med, Sch Nursing, Beijing, Peoples R China.
   [Chen, Yufeng] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China.
   [Zhai, Xing; Chu, Yupeng] Beijing Univ Chinese Med, Sch Management, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine
RP Liu, XD; Ma, XL (corresponding author), Beijing Univ Chinese Med, Sch Nursing, Beijing, Peoples R China.
EM 13810693238@126.com; maxl@bucm.edu.cn
OI Chen, Yufeng/0009-0007-9457-365X
FU National Natural Science Foundation of China [81503382]; Key project of
   Beijing University of Chinese Medicine [2020-JYB-ZDGG-078]; Vertical
   Science Development Foundation of BUCM [2019-ZXFZJJ-039]
FX Funding This study was supported by the National Natural Science
   Foundation of China (No. 81503382), the Key project of Beijing
   University of Chinese Medicine (2020-JYB-ZDGG-078), and the Vertical
   Science Development Foundation of BUCM (2019-ZXFZJJ-039).
CR Afshar MK, 2015, IRAN RED CRESCENT ME, V17, DOI 10.5812/ircmj.17(4)2015.25880
   Afshar M, 2018, COMPLEMENT THER MED, V40, P37, DOI 10.1016/j.ctim.2018.07.006
   Airagnes G, 2016, CURR PSYCHIAT REP, V18, DOI 10.1007/s11920-016-0727-9
   Ancoli-Israel S, 2014, SUPPORT CARE CANCER, V22, P2535, DOI 10.1007/s00520-014-2204-5
   Arai YCP, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/945063
   Bergdahl L, 2017, COMPLEMENT THER CLIN, V28, P220, DOI 10.1016/j.ctcp.2017.06.006
   Bikmoradi A, 2015, COMPLEMENT THER MED, V23, P331, DOI 10.1016/j.ctim.2014.12.001
   Blackburn L, 2017, ONCOL NURS FORUM, V44, pE185, DOI 10.1188/17.ONF.E185-E193
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1002/smll.202408771
   Carotenuto M, 2013, NEUROPSYCH DIS TREAT, V9, P157, DOI 10.2147/NDT.S41892
   Castelnovo A, 2019, SLEEP MED REV, V44, P70, DOI 10.1016/j.smrv.2018.12.007
   Celikkayalar E, 2021, PATIENT PREFER ADHER, V15, P141, DOI 10.2147/PPA.S280503
   Chen CM, 2006, J AM SOC INF SCI TEC, V57, P359, DOI 10.1002/asi.20317
   Chen HY, 2007, J ALTERN COMPLEM MED, V13, P669, DOI 10.1089/acm.2006.6400
   Chen IH, 2019, J AM MED DIR ASSOC, V20, P822, DOI 10.1016/j.jamda.2019.01.003
   Chen PJ, 2017, SLEEP MED, V38, P122, DOI 10.1016/j.sleep.2017.07.016
   Cheong MJ, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000024652
   Chien LW, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/740813
   Chinese Medicine Academy of Chinese Medicine Insomnia Clinical practice Guidelines research group, 2016, World J Sleep Med, V3, P8
   Chinese Society of Neurology, 2018, Chin J Neurol, V51, P324, DOI [10.3760/cma.j.issn.1006-7876.2018.05.002, DOI 10.3760/CMA.J.ISSN.1006-7876.2018.05.002]
   Cho EH, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/2856592
   Cho MY, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/381381
   Choi H, 2020, PSYCHIAT INVEST, V17, P1048, DOI 10.30773/pi.2020.0146
   Dopheide JA, 2020, AM J MANAG CARE, V26, pS76, DOI [10.37765/ajmc.2020.42769, 10.37765/ajmc.2020.42769]
   Edinger JD, 2016, SLEEP MED, V26, P69, DOI 10.1016/j.sleep.2016.03.005
   Farmer AD, 2021, FRONT HUM NEUROSCI, V14, DOI 10.3389/fnhum.2020.568051
   Guo FF., CHINESE ARCH TCM, P1
   Huang JK, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/6920902
   Insomnia cooperative group of state administration of traditional chinese medicine, 2015, WORLD J SLEEP MED, V2, P14
   Jiao Y, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/6049891
   Jiao Y, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/578972
   Johnson EO, 2006, J PSYCHIATR RES, V40, P700, DOI 10.1016/j.jpsychires.2006.07.008
   Ju MS, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/403251
   Kao CL, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/567639
   Karadag E, 2017, NURS CRIT CARE, V22, P105, DOI 10.1111/nicc.12198
   Kim ME, 2019, J KOREAN ACAD NURS, V49, P655, DOI 10.4040/jkan.2019.49.6.655
   Koffel E, 2018, J GEN INTERN MED, V33, P955, DOI 10.1007/s11606-018-4390-1
   Kuo HC, 2018, RES NURS HEALTH, V41, P469, DOI 10.1002/nur.21885
   Lai FC, 2017, J AM GERIATR SOC, V65, pE103, DOI 10.1111/jgs.14729
   Lan Y, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0606-7
   Lee MK, 2017, EUR J INTEGR MED, V12, P79, DOI 10.1016/j.eujim.2017.04.009
   Li Li-Chun, 2018, Zhen Ci Yan Jiu, V43, P573, DOI 10.13702/j.1000-0607.170765
   Li X, 2021, J AM COLL CARDIOL, V78, P1197, DOI 10.1016/j.jacc.2021.07.023
   Li ZH, 2021, EUR J ENDOCRINOL, V185, P765, DOI 10.1530/EJE-21-0314
   Liang S., 2018, World Clin Drugs, V39, P217
   Lillehei AS, 2014, J ALTERN COMPLEM MED, V20, P441, DOI 10.1089/acm.2013.0311
   Liu S., 2017, CHINESE J CONT NEURO, V17, P633, DOI DOI 10.3969/J.ISSN.1672-6731.2017.09.002
   McArdle N, 2022, J CLIN SLEEP MED, V18, P1503, DOI 10.5664/jcsm.9886
   Meng Fang, 2018, Zhongguo Zhen Jiu, V38, P575, DOI 10.13703/j.0255-2930.2018.06.002
   Mirchandaney R, 2022, CURR PSYCHIAT REP, V24, P121, DOI 10.1007/s11920-022-01326-3
   Muz G, 2017, APPL NURS RES, V37, P28, DOI 10.1016/j.apnr.2017.07.004
   National Administration of Traditional Chinese Medicine, 2015, NOT PRINT DISTR TCM
   Ni J, 2018, J TRADIT CHIN MED, V38, P763
   Nielsen A, 2020, PAIN MED, V21, P1276, DOI 10.1093/pm/pnz379
   Pei M, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.576050
   Ree M, 2017, SLEEP MED, V36, pS43, DOI 10.1016/j.sleep.2017.03.017
   Riemann D, 2017, J SLEEP RES, V26, P675, DOI 10.1111/jsr.12594
   Rosenberg RP, 2021, J CLIN PSYCHIAT, V82, DOI 10.4088/JCP.EI20008AH5C
   Samara MT, 2020, ACTA PSYCHIAT SCAND, V142, P6, DOI 10.1111/acps.13201
   Sentürk A, 2018, HOLIST NURS PRACT, V32, P324, DOI 10.1097/HNP.0000000000000292
   Tan JY, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/506758
   Tang YH, 2021, J AFFECT DISORDERS, V288, P1, DOI 10.1016/j.jad.2021.03.066
   Taylor DJ, 2005, SLEEP, V28, P1457, DOI 10.1093/sleep/28.11.1457
   Usichenko T, 2017, BRAIN STIMUL, V10, P1042, DOI 10.1016/j.brs.2017.07.013
   Usichenko TI, 2018, MED ACUPUNCT, V30, P308, DOI 10.1089/acu.2018.1314
   Vieira A, 2018, COMPLEMENT THER CLIN, V33, P61, DOI 10.1016/j.ctcp.2018.08.005
   Wang XT, 2020, COMPLEMENT THER CLIN, V39, DOI 10.1016/j.ctcp.2020.101151
   Wang ZJ, 2017, EUR J INTEGR MED, V15, P17, DOI 10.1016/j.eujim.2017.08.010
   Wu Y, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/7178711
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Yeh CH, 2016, BEHAV SLEEP MED, V14, P279, DOI 10.1080/15402002.2014.981820
   Yeung WF, 2018, J SLEEP RES, V27, P220, DOI 10.1111/jsr.12597
   Yeung WF, 2012, SLEEP MED, V13, P971, DOI 10.1016/j.sleep.2012.06.003
   Yufang H., 2020, FUNDAMENTALS TRADITI
   Zhao B, 2019, BRAIN STIMUL, V12, P824, DOI 10.1016/j.brs.2019.02.016
   Zhao ZH, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/7279486
   Zou GY, 2021, HUM BRAIN MAPP, V42, P259, DOI 10.1002/hbm.25221
NR 77
TC 17
Z9 19
U1 14
U2 145
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD MAR 31
PY 2022
VL 13
AR 816031
DI 10.3389/fneur.2022.816031
PG 16
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA 0U8SQ
UT WOS:000787918200001
PM 35432182
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, MJ
   Peng, HW
   Wei, BX
   Deng, QX
   Qian, F
   Liu, X
   Wang, J
   Zhu, XD
AF Li, Maojun
   Peng, Huawen
   Wei, Binxiu
   Deng, Qiuxia
   Qian, Fen
   Liu, Xin
   Wang, Jian
   Zhu, Xiaodong
TI Effect of acupuncture anesthesia based on nanomaterial sensor on
   cognitive function after one-lung ventilation thoracotomy
SO MATERIALS EXPRESS
LA English
DT Article
DE One-Lung Ventilation and Thoracotomy; Acupuncture Anesthesia;
   Nanomaterials; Inflammatory Factors; Cognitive Function
ID OPEN-HEART-SURGERY; STRESS-RESPONSE; TNF-ALPHA; IL-6; PAIN
AB In this work, a new type of nanomaterial sensing acupuncture needle was developed to improve patient comfort and treatment effectiveness. Based on the convenient electrochemical casting process, multilayer nano-tapered holes were constructed on the needle surface to form a porous nano-sensing acupuncture needle (PNAN), which further increases the interface area of the acupuncture needle. To evaluate the effect of PNAN-induced anesthesia on cognitive function after one-lung ventilation and thoracotomy, 60 patients with esophageal cancer undergoing thoracotomy were randomly divided into an acupuncture-induced anesthesia (AIA) group and a conventional anesthesia (CA) group. The recovery time for cognitive function and the incidence of cognitive impairment in the PNAN-induced anesthesia group after one-lung ventilation and thoracotomy were significantly lower than those of the CA group (P < 0.05). The scores from the Mini Mental State Examination Scale (MMSE) and Self-Rating Anxiety Scale (SAS) for the AIA group were lower than the preoperative scores and were better than those for the CA group (P < 0.05). In addition, after one-lung ventilation and thoracotomy, the concentrations of cytokines and catecholamines (CAs) in both groups were lower than the preoperative values, and the levels of cytokines and CAs in the AIA group were significantly lower than those of the CA group. Therefore, acupuncture anesthesia based on a nanomaterial sensor can significantly improve the cognitive function of patients after one-lung ventilation and thoracotomy, inhibit inflammatory factors, and provide an optimal curative effect.
C1 [Li, Maojun; Wei, Binxiu; Deng, Qiuxia; Qian, Fen; Liu, Xin] Peoples Hosp Linshui Cty, Dept Anesthesiol, Guangan 638500, Sichuan, Peoples R China.
   [Peng, Huawen; Zhu, Xiaodong] Peoples Hosp Linshui Cty, Dept Orthoped, Guangan 638500, Sichuan, Peoples R China.
   [Wang, Jian] Peoples Hosp Linshui Cty, Dept Cardiothorac Surg, Guangan 638500, Sichuan, Peoples R China.
RP Zhu, XD (corresponding author), Peoples Hosp Linshui Cty, Dept Orthoped, Guangan 638500, Sichuan, Peoples R China.; Wang, J (corresponding author), Peoples Hosp Linshui Cty, Dept Cardiothorac Surg, Guangan 638500, Sichuan, Peoples R China.
FU Guang'an Municipal Science and Technology Innovation Project [2019SYF11]
FX This work was supported by funding from the Guang'an Municipal Science
   and Technology Innovation Project [2019SYF11]. And we very grateful for
   the People's Hospital of Linshui County's support and encouragement in
   many ways.
CR Cheng TO, 2000, HEART, V83, P256, DOI 10.1136/heart.83.3.256
   Chung A, 2003, CAN FAM PHYSICIAN, V49, P985
   DEGROOTE D, 1992, CYTOKINE, V4, P239, DOI 10.1016/1043-4666(92)90062-V
   Hata H, 2004, J CLIN INVEST, V114, P582, DOI 10.1172/JCI200421795
   HOLLINGER I, 1979, AM J CHINESE MED, V7, P77, DOI 10.1142/S0192415X79000064
   HYODO M, 1977, AM J CHINESE MED, V5, P63, DOI 10.1142/S0192415X77000075
   In SL, 2016, SCI REP-UK, V6, DOI 10.1038/srep34061
   Ji Shu-Mei, 2007, Zhongguo Zhen Jiu, V27, P306
   Kang YJ, 2011, CELL DEATH DIFFER, V18, P133, DOI 10.1038/cdd.2010.82
   Kaptchuk TJ, 2002, ANN INTERN MED, V136, P374, DOI 10.7326/0003-4819-136-5-200203050-00010
   Kato S, 1995, Noshuyo Byori, V12, P125
   Langevin Helene M., 2002, Anatomical Record, V269, P257, DOI 10.1002/ar.10185
   Lee BR, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11213-0
   Liu Xiao-ying, 2007, Zhonghua Yi Xue Za Zhi, V87, P1025
   Lu YJ, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-178
   Mao Jinfeng, 2018, Zhongguo Zhen Jiu, V38, P761, DOI 10.13703/j.0255-2930.2018.07.021
   Shang AB, 2003, DRUGS, V63, P855, DOI 10.2165/00003495-200363090-00002
   Taguchi R, 2008, EVID-BASED COMPL ALT, V5, P153, DOI 10.1093/ecam/nem056
   TSUJIMOTO T, 1978, Medical Journal of Osaka University, V28, P355
   Wang D., 1990, FUKUSHIMA J MED SCI, V35, P45
   Weber GF, 2000, J MOL MED-JMM, V78, P404, DOI 10.1007/s001090000138
   White Adrian, 2006, Acupunct Med, V24, P39
   ZANELLA G, 1968, TRANSPLANTATION, V6, P885, DOI 10.1097/00007890-196811000-00003
   Zhen Hong-Liang, 2008, Zhongguo Zhen Jiu, V28, P736
   Zhou J, 2011, INT J CARDIOL, V150, P12, DOI 10.1016/j.ijcard.2011.04.002
NR 25
TC 2
Z9 2
U1 5
U2 27
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 2158-5849
EI 2158-5857
J9 MATER EXPRESS
JI Mater. Express
PD JUL
PY 2021
VL 11
IS 7
BP 1051
EP 1056
DI 10.1166/mex.2021.2027
PG 6
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Materials Science
GA TM7JZ
UT WOS:000675725600006
DA 2026-01-16
ER

PT J
AU Ren, ZQ
   Wang, Y
   Zhu, WH
   Dou, HM
   Cao, XH
   Hong, H
   Azhen,
AF Ren Zhenqing
   Wang Yan
   Zhu Weihua
   Dou Hongmei
   Cao Xiuhong
   Hong Hua
   Yuan Azhen
TI Efficacy of acupoint massage combined with acupoint application on
   arterial blood gas in patients undergoing laparoscopic cholecystectomy
SO PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Acupoint massage; acupoint application; blood gas; laparoscopic
   cholecystectomy The NCT number of original study was NCT02096835
ID POSTOPERATIVE NAUSEA; LUNG-CANCER; SURGERY
AB To explore efficacy of acupoint massage combined with acupoint application on arterial blood gas and postoperative complications for patients undergoing laparoscopic cholecystectomy. Patients undergoing laparoscopic cholecystectomy (LC) in general anesthesia condition were randomly enrolled from local hospital into control group and experimental group. Four acupuncture points were prepared for acupoint massage and acupoint application, including bilateral Hegu acupoint (LI4), Neiguan Point (PC6), Zusanli Point (ST36) and Tanzhong acupoint (CV17). All patients in experimental group were treated with point acupressure treatment combined with acupoint application before LC, while control group directly receive LC surgery. The peak inspiratory pressure (PIP), end-tidal CO2 pressure (PETCO2), oxygen saturation (SpO(2)) and pH were examined at multiple time points during LC surgery. Related postoperative complications were documented for further analysis. All data were analyzed to assess efficacy of acupoint massage combined with acupoint application on arterial blood gas. There is no difference in baseline condition between experimental group and control group. Compared with control group, PetCO(2) and SpO(2) in experimental group were significantly increased while PIP was decreased. PH in experimental group ranged in a more stable domain. Hypercapnia and deep venous thrombosis were mitigated in experimental group compared with control group. Moreover, multiple pneumoperitoneum-related complications were alleviated after combined treatment, including pain and frequency of nausea and vomiting. Acupoint massage combined with acupoint application ameliorated related postoperative complications, and reduced side events of LC surgery via improving carbon dioxide metabolism.
C1 [Ren Zhenqing; Wang Yan; Zhu Weihua; Dou Hongmei; Cao Xiuhong; Hong Hua] Taizhou Peoples Hosp, Operat Dept, Taizhou, Peoples R China.
   [Yuan Azhen] Taizhou Peoples Hosp, Nursing Dept, Taizhou, Peoples R China.
RP Azhen, (corresponding author), Taizhou Peoples Hosp, Nursing Dept, Taizhou, Peoples R China.
EM yuanazhendr@163.com
FU Medical Clinical Science and Technology Development Funding of Jiangsu
   University, China
FX This study was supported by Medical Clinical Science and Technology
   Development Funding of Jiangsu University, China.
CR Akbarzade Marzieh, 2016, J Reprod Infertil, V17, P39
   Akbarzadeh Marzieh, 2014, Int J Community Based Nurs Midwifery, V2, P112
   Antor MA, 2014, FRONT PHARMACOL, V5, DOI 10.3389/fphar.2014.00055
   Braga ELC, 2019, EUR J ANAESTH, V36, P241, DOI 10.1097/EJA.0000000000000932
   Fathy M, 2019, OBES SURG, V29, P1614, DOI 10.1007/s11695-019-03762-2
   Giménez ME, 2018, ABCD-ARQ BRAS CIR DI, V31, DOI 10.1590/0102-672020180001e1380
   Grillo CM, 2014, J ACUPUNCT MERIDIAN, V7, P65, DOI 10.1016/j.jams.2013.03.005
   Kim HJ, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000014339
   Li Y, 2017, J CANCER RES THER, V13, P844, DOI 10.4103/jcrt.JCRT_709_17
   Liu BY, 2018, CHIN J INTEGR MED, V24, P260, DOI 10.1007/s11655-018-2798-4
   Lu Chao, 2019, Zhongguo Zhen Jiu, V39, P9, DOI 10.13703/j.0255-2930.2019.01.002
   Luo J, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0676-6
   Mayberry John F, 2018, Med Leg J, V86, P23, DOI [10.1177/0025817217734482, 10.1177/0025817217734482]
   Mehta Piyush, 2015, J Tradit Complement Med, V5, P127, DOI [10.1016/j.jtcme.2014.11.036, 10.1016/j.jtcme.2014.11.036]
   Meng Xin-liang, 2016, Zhen Ci Yan Jiu, V41, P74
   Ng JY, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1410-8
   Niemtzow R, 2018, MIL MED, V183, pE486, DOI 10.1093/milmed/usy028
   Rozenfeld E, 2016, J BODYW MOV THER, V20, P173, DOI 10.1016/j.jbmt.2015.11.009
   Shu Q, 2016, FORSCH KOMPLEMENTMED, V23, P336, DOI 10.1159/000448207
   Wang Q, 2015, INT J CARDIOL, V194, P28, DOI 10.1016/j.ijcard.2015.05.043
   Wildes TS, 2019, JAMA-J AM MED ASSOC, V321, P473, DOI 10.1001/jama.2018.22005
   Yao L, 2017, SURG LAPARO ENDO PER, V27, P346, DOI 10.1097/SLE.0000000000000463
   Yeoh AH, 2016, TURK J MED SCI, V46, P620, DOI 10.3906/sag-1502-56
   Youssef N, 2014, ANESTH ANALG, V119, P965, DOI 10.1213/ANE.0000000000000377
   Zhang LL, 2016, J PAIN SYMPTOM MANAG, V51, P504, DOI 10.1016/j.jpainsymman.2015.11.020
NR 25
TC 4
Z9 5
U1 1
U2 24
PU UNIV KARACHI
PI KARACHI
PA UNIV CAMPUS, FAC PHARMACY, KARACHI, 75270, PAKISTAN
SN 1011-601X
J9 PAK J PHARM SCI
JI Pak. J. Pharm. Sci.
PD MAY
PY 2019
VL 32
IS 3
SI SI
BP 1375
EP 1380
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IF7GI
UT WOS:000473249100015
PM 31551218
DA 2026-01-16
ER

PT J
AU Zhang, WZ
   Chin, KY
   Zakaria, R
   Hassan, NH
AF Zhang, Wei-Zheng
   Chin, Kok-Yong
   Zakaria, Roshaya
   Hassan, Nor Haty
TI Strategies for Pain Management in Hepatocellular Carcinoma Patients
   Undergoing Transarterial Chemoembolisation: A Scoping Review of Current
   Evidence
SO HEALTHCARE
LA English
DT Review
DE hepatocellular carcinoma; transarterial chemoembolisation (TACE); pain
   management; scoping review
ID TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; POSTEMBOLIZATION SYNDROME;
   INTRAARTERIAL LIDOCAINE; LIVER-CANCER; RELIEF; DEXAMETHASONE;
   ACUPUNCTURE; EFFICACY; STEROIDS; THERAPY
AB Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with transarterial chemoembolisation (TACE) being a primary treatment for intermediate-stage disease. However, post-procedural pain remains a significant challenge due to inconsistent management practices and a lack of standardised protocols. This scoping review synthesises current evidence on pain management strategies in HCC patients undergoing TACE, evaluates their effectiveness, identifies practice gaps, and proposes optimisation strategies. Methods: A comprehensive database search according to the methodological approach given by Arksey and O'Malley with the aid of the PRISMA-ScR guidelines across Cochrane Library, Web of Science, CINAHL, PubMed, and Scopus was performed. The terms associated with pain, TACE, and liver cancer were included in the search strategy. Two independent researchers systematically screened study titles, abstracts, and full texts and extracted key study characteristics and approaches to pain management. Results: Of 1515 identified studies, 29 met the inclusion criteria. Most (72.7%) focused on pharmacological interventions, with dexamethasone and lidocaine being the most frequently investigated agents. Non-pharmacological approaches, including psychological interventions, physical therapies, music therapy, health education, and comprehensive nursing, were also reported. Pain was primarily assessed using the visual analogue scale (VAS) and numeric rating scale (NRS). Conclusions: Pharmacological interventions, particularly dexamethasone and lidocaine, remain the cornerstone of pain management in TACE, yet consensus on their optimal use is lacking. Non-pharmacological strategies provide complementary benefits. standardised, evidence-based pain management protocols integrating both approaches are needed. Future large-scale, multicentre trials are essential to establish the most effective strategies for optimising patient outcomes.
C1 [Zhang, Wei-Zheng; Zakaria, Roshaya; Hassan, Nor Haty] Univ Kebangsaan Malaysia, Fac Med, Dept Nursing, Kuala Lumpur 56000, Malaysia.
   [Chin, Kok-Yong] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Hassan, NH (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Nursing, Kuala Lumpur 56000, Malaysia.
EM p119154@siswa.ukm.edu.my; chinky@ukm.edu.my; roshaya@hctm.ukm.edu.my;
   norhaty@hctm.ukm.edu.my
RI ; Chin, Kok-Yong/B-6309-2015
OI Zakaria, Roshaya/0000-0002-4764-5178; 
FU Universiti Kabangsaan Malaysia
FX We thank Universiti Kabangsaan Malaysia for the support. We have
   usedDeepseek V3 AI and Youdao 11.1.2 AI to polish the language of the
   manuscript. However, the authorsare responsible for the content of the
   manuscript.
CR Abusedera MA, 2014, EGYPT J RADIOL NUC M, V45, P403, DOI 10.1016/j.ejrnm.2014.03.005
   Alruwaili M.O.S., 2024, Gland Surg, V9, P316
   Arksey H., 2005, INT J SOC RES METHOD, V8, P19, DOI [10.1080/1364557032000119616, DOI 10.1080/1364557032000119616]
   Bian LF, 2020, WORLD J GASTROENTERO, V26, P4442, DOI 10.3748/wjg.v26.i30.4442
   Chadwick A, 2021, J PAIN RES, V14, P3145, DOI 10.2147/JPR.S320863
   Chang KT, 2020, INT J NURS STUD, V109, DOI 10.1016/j.ijnurstu.2020.103641
   Chang Y, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218165
   Chapman EJ, 2020, PALLIATIVE MED, V34, P444, DOI 10.1177/0269216319896955
   Du QQ, 2023, EUR J ONCOL NURS, V66, DOI 10.1016/j.ejon.2023.102355
   Feng YL, 2009, J ALTERN COMPLEM MED, V15, P175, DOI 10.1089/acm.2008.0093
   Gao LL, 2024, MEDICINE, V103, DOI 10.1097/MD.0000000000035929
   GREEN S, 1992, INVEST NEW DRUG, V10, P239, DOI 10.1007/BF00944177
   Guo JG, 2018, HEPATOB PANCREAT DIS, V17, P510, DOI 10.1016/j.hbpd.2018.08.001
   Hartnell GG, 1999, CARDIOVASC INTER RAD, V22, P293, DOI 10.1007/s002709900391
   Khuntee W, 2022, BELITUNG NURS J, V8, P396, DOI 10.33546/bnj.2210
   Kim MS, 2024, CANCER NURS, V47, pE226, DOI 10.1097/NCC.0000000000001211
   Kogut MJ, 2013, J VASC INTERV RADIOL, V24, P326, DOI 10.1016/j.jvir.2012.11.019
   Kuwaki K, 2019, ACTA MED OKAYAMA, V73, P333, DOI 10.18926/AMO/56935
   Labgaa I, 2020, LIVER CANCER, V9, P138, DOI 10.1159/000505093
   Lee SH, 2001, CARDIOVASC INTER RAD, V24, P368, DOI 10.1007/s00270-001-0073-z
   Liang J, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/6169183
   Lin JG, 2022, AM J TRANSL RES, V14, P1469
   Lin LF, 2021, J HEMATOL ONCOL, V14, DOI 10.1186/s13045-021-01213-z
   Lin ZG, 2022, J ACUPUNCT TUINA SCI, V20, P383, DOI 10.1007/s11726-022-1320-x
   Lu HH, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000035433
   Lu HH, 2021, BMC GASTROENTEROL, V21, DOI 10.1186/s12876-021-01839-w
   Lv N, 2016, EUR RADIOL, V26, P3492, DOI 10.1007/s00330-016-4207-8
   Lyu N, 2022, J AM COLL RADIOL, V19, P61, DOI 10.1016/j.jacr.2021.09.029
   Makary MS, 2020, CANCERS, V12, DOI 10.3390/cancers12071914
   McGlynn KA, 2021, HEPATOLOGY, V73, P4, DOI 10.1002/hep.31288
   Molgaard C P, 1990, J Vasc Interv Radiol, V1, P81, DOI 10.1016/S1051-0443(90)72508-0
   Munn Z, 2018, BMC MED RES METHODOL, V18, DOI 10.1186/s12874-018-0611-x
   Nielsen A, 2022, PAIN MED, V23, P1582, DOI 10.1093/pm/pnac056
   Niyonkuru E, 2025, PAIN THER, V14, P121, DOI 10.1007/s40122-024-00688-1
   Francisco ASPG, 2021, PAIN MANAG NURS, V22, P121, DOI 10.1016/j.pmn.2020.07.006
   Ruano A, 2022, J PAIN SYMPTOM MANAG, V63, pE505, DOI 10.1016/j.jpainsymman.2021.12.021
   Sainamthip P, 2021, WORLD J CLIN CASES, V9, P9059, DOI 10.12998/wjcc.v9.i30.9059
   Simasingha N, 2023, WORLD J GASTROENTERO, V29, P890, DOI 10.3748/wjg.v29.i5.890
   Sinatti P, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19106194
   Tang HK, 2021, SUPPORT CARE CANCER, V29, P7299, DOI 10.1007/s00520-021-06152-6
   Tricco AC, 2018, ANN INTERN MED, V169, P467, DOI 10.7326/M18-0850
   Turk DC, 2002, J CONSULT CLIN PSYCH, V70, P678, DOI 10.1037//0022-006X.70.3.678
   Vanderbecq Q, 2023, DIAGN INTERV IMAG, V104, P123, DOI 10.1016/j.diii.2022.10.013
   Varsi C, 2021, BMC HEALTH SERV RES, V21, DOI 10.1186/s12913-021-06278-7
   Velikova G, 2022, Programme Grants for Applied Research, V10, P1, DOI [10.3310/fdde8516, 10.3310/fdde8516, DOI 10.3310/FDDE8516, 10.3310/FDDE8516]
   Vitale A, 2020, HEPATOLOGY, V72, P2206, DOI 10.1002/hep.31187
   Wally MK, 2022, J ORTHOP TRAUMA, V36, pS19, DOI 10.1097/BOT.0000000000002457
   Wang LZ, 2021, J HEPATOCELL CARCINO, V8, P1221, DOI 10.2147/JHC.S331779
   Wang ZX, 2018, J PAIN RES, V11, P2115, DOI 10.2147/JPR.S166333
   Wang ZX, 2008, WORLD J GASTROENTERO, V14, P931, DOI 10.3748/wjg.14.931
   Xu H, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6269518
   Xu LT, 2016, INTEGR CANCER THER, V15, P349, DOI 10.1177/1534735415617020
   Yang H, 2017, J VASC INTERV RADIOL, V28, P1503, DOI 10.1016/j.jvir.2017.07.021
   Yang J, 2021, BMJ SUPPORT PALLIAT, V11, P264, DOI 10.1136/bmjspcare-2020-002638
   Yu JM, 2020, INT J CLIN EXP MED, V13, P1687
   Zeng K, 2014, AM J CHINESE MED, V42, P289, DOI 10.1142/S0192415X14500190
   Zhou B, 2012, RADIOLOGY, V262, P1014, DOI 10.1148/radiol.11110552
   Zhou ZG, 2016, ONCOTARGET, V7, P27938, DOI 10.18632/oncotarget.8560
NR 58
TC 2
Z9 2
U1 4
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD APR 25
PY 2025
VL 13
IS 9
AR 994
DI 10.3390/healthcare13090994
PG 19
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 2MO0Y
UT WOS:001486212700001
PM 40361772
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Magno, S
   Filippone, A
   Scaldaferri, A
AF Magno, Stefano
   Filippone, Alessio
   Scaldaferri, Assunta
TI Evidence-based usefulness of integrative therapies in breast cancer
SO TRANSLATIONAL CANCER RESEARCH
LA English
DT Review
DE Integrative oncology; precision medicine; lifestyle; complementary
   therapies; breast cancer (BC)
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; MUSIC-THERAPY; ALTERNATIVE MEDICINE;
   POSTOPERATIVE PAIN; RADICAL-MASTECTOMY; DOUBLE-BLIND; HOT FLASHES; OLIVE
   OIL; ACUPUNCTURE
AB In a modern concept of Precision Medicine, clinical approach should be tailored to a single patient with cancer rather than only to cancer itself, by combining a deep understanding of genetic and molecular features of her disease, the most updated and evidence-based treatments available and patient's values and needs. Integrative oncology is a global strategy that includes lifestyle interventions and complementary therapies into mainstream care, to reduce the huge impact of oncological treatments for breast cancer (BC) both on patients' physical and psycho-social aspects of life at any ages. This paper summarizes the major clinical and scientific evidences about the impact of lifestyle changes and usefulness of complementary treatments currently used in breast cancer management.
C1 [Magno, Stefano; Filippone, Alessio; Scaldaferri, Assunta] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli, Multidisciplinary Breast Ctr, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Magno, S (corresponding author), Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli, Multidisciplinary Breast Ctr, Rome, Italy.
EM stefano.magno@policlinicogemelli.it
RI MAGNO, STEFANO/AAD-8430-2022
OI MAGNO, STEFANO/0000-0002-3721-9693; Filippone,
   Alessio/0000-0002-3978-846X
CR Al-Regaiey KA, 2007, J GERONTOL A-BIOL, V62, P18, DOI 10.1093/gerona/62.1.18
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Ammitzboll G, 2016, EUR J CANCER, V66, P67, DOI 10.1016/j.ejca.2016.07.010
   Arends J, 2017, CLIN NUTR, V36, P11, DOI 10.1016/j.clnu.2016.07.015
   Berrino F, 2005, INT J CANCER, V113, P499, DOI 10.1002/ijc.20582
   Berrino F, 2001, CANCER EPIDEM BIOMAR, V10, P25
   Binns-Turner Pamela G, 2011, AANA J, V79, pS21
   Boehm K, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/103297
   Bonkowski MS, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004567
   Bulfone T, 2009, HOLIST NURS PRACT, V23, P238, DOI 10.1097/HNP.0b013e3181aeceee
   Chen Z, 2013, CANCER-AM CANCER SOC, V119, P1690, DOI 10.1002/cncr.27904
   Chlebowski RT, 2002, J CLIN ONCOL, V20, P1128, DOI 10.1200/JCO.20.4.1128
   Cichewicz DL, 2004, LIFE SCI, V74, P1317, DOI 10.1016/j.lfs.2003.09.038
   Cichewicz DL, 2003, J PHARMACOL EXP THER, V304, P1010, DOI 10.1124/jpet.102.045575
   Colau JC, 2012, DRUGS R&D, V12, P107, DOI 10.2165/11640240-000000000-00000
   Cramer H, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010802.pub2
   Demark-Wahnefried W, 2012, CANCER-AM CANCER SOC, V118, P2277, DOI 10.1002/cncr.27466
   Deng G, 2013, SUPPORT CARE CANCER, V21, P1735, DOI 10.1007/s00520-013-1720-z
   Deng Gary E, 2009, J Soc Integr Oncol, V7, P85
   Escrivá F, 2007, J ENDOCRINOL, V194, P131, DOI 10.1677/joe.1.07043
   Everdingen MHJVDBV, 2007, ANN ONCOL, V18, P1437, DOI 10.1093/annonc/mdm056
   Felgines C, 1999, JPEN-PARENTER ENTER, V23, P32, DOI 10.1177/014860719902300132
   Filaire E., 2004, J EXERC PHYSL ONLINE, V7, P37
   Friedenreich CM, 2010, EUR J CANCER, V46, P2593, DOI 10.1016/j.ejca.2010.07.028
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Gecsedi Renee A, 2002, Clin J Oncol Nurs, V6, P52
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Grotenhermen F, 2012, DTSCH ARZTEBL INT, V109, P495, DOI 10.3238/arztebl.2012.0495
   Hanser Suzanne B, 2006, J Soc Integr Oncol, V4, P116, DOI 10.2310/7200.2006.014
   Husebo AML, 2014, SCI WORLD J, DOI [10.1155/2014/689873, 10.1155/2014/271828]
   Iannitti T, 2016, AM J THER, V23, pE184, DOI 10.1097/MJT.0000000000000036
   Iida N, 2013, SCIENCE, V342, P967, DOI 10.1126/science.1240527
   Ismail AM, 2013, FOOD CHEM TOXICOL, V62, P817, DOI 10.1016/j.fct.2013.10.024
   Jacobsen PB, 2013, PSYCHO-ONCOLOGY, V22, P1229, DOI 10.1002/pon.3122
   John GM, 2016, J CANCER SURVIV, V10, P850, DOI 10.1007/s11764-016-0530-y
   Jung S, 2013, JNCI-J NATL CANCER I, V105, P219, DOI 10.1093/jnci/djs635
   Kaaks R, 2003, EUR J CLIN NUTR, V57, P1079, DOI 10.1038/sj.ejcn.1601647
   Kassab S, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004845.pub2
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Li XM, 2012, J ADV NURS, V68, P1145, DOI 10.1111/j.1365-2648.2011.05824.x
   Li YY, 2010, CLIN CANCER RES, V16, P2580, DOI 10.1158/1078-0432.CCR-09-2937
   Loi CXA, 2012, J PSYCHOSOC ONCOL, V30, P57, DOI 10.1080/07347332.2011.633981
   Lu WD, 2008, HEMATOL ONCOL CLIN N, V22, P631, DOI 10.1016/j.hoc.2008.04.005
   Lynch ME, 2011, BRIT J CLIN PHARMACO, V72, P735, DOI 10.1111/j.1365-2125.2011.03970.x
   Lynch SV, 2016, NEW ENGL J MED, V375, P2369, DOI 10.1056/NEJMra1600266
   Magno S, 2016, Integrative Cancer Science and Therapeutics, V3, P460, DOI [10.15761/icst.1000188, DOI 10.15761/ICST.1000188]
   Mao JJ, 2015, J CLIN ONCOL, V33, P3615, DOI 10.1200/JCO.2015.60.9412
   Martens EC, 2008, CELL HOST MICROBE, V4, P447, DOI 10.1016/j.chom.2008.09.007
   Marvibaigi M, 2014, BIOMED RES INT-UK, V2014, DOI 10.1155/2014/785479
   McTiernan A, 2008, NAT REV CANCER, V8, P205, DOI 10.1038/nrc2325
   Memorial Sloan Kettering Cancer Center, INT MED HERBS BOT OT
   Menendez JA, 2005, ANN ONCOL, V16, P359, DOI 10.1093/annonc/mdi090
   Molassiotis A, 2005, ANN ONCOL, V16, P655, DOI 10.1093/annonc/mdi110
   Morgan N, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100903
   Neef A, 2013, CURR OPIN CLIN NUTR, V16, P679, DOI 10.1097/MCO.0b013e328365c258
   Oberbaum M, 2001, CANCER, V92, P684, DOI 10.1002/1097-0142(20010801)92:3<684::AID-CNCR1371>3.0.CO;2-#
   Oh B, 2010, ANN ONCOL, V21, P608, DOI 10.1093/annonc/mdp479
   Paley CA, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub2
   Pasanisi P, 2006, INT J CANCER, V119, P236, DOI 10.1002/ijc.21812
   Phillips KM, 2008, PSYCHOSOM MED, V70, P1044, DOI 10.1097/PSY.0b013e318186fb27
   Pommier P, 2004, J CLIN ONCOL, V22, P1447, DOI 10.1200/JCO.2004.07.063
   Roberts JD, 2006, EUR J PHARMACOL, V530, P54, DOI 10.1016/j.ejphar.2005.11.036
   Sagar SM, 2008, CURR TREAT OPTION ON, V9, P117, DOI 10.1007/s11864-008-0063-3
   Schure MB, 2008, J COUNS DEV, V86, P47, DOI 10.1002/j.1556-6678.2008.tb00625.x
   Semiglazov VF, 2006, ANTICANCER RES, V26, P1519
   Shimokawa I, 2003, FASEB J, V17, P1108, DOI 10.1096/fj.02-0819fje
   Sivan A, 2015, SCIENCE, V350, P1084, DOI 10.1126/science.aac4255
   Sontakke S, 2011, INDIAN J PHARM, V35, P32
   Sun Y, 2008, BRIT J ANAESTH, V101, P151, DOI 10.1093/bja/aen146
   Thomas RM, 2015, TRENDS CANCER, V1, P24, DOI 10.1016/j.trecan.2015.07.005
   Toledo E, 2015, JAMA INTERN MED, V175, P1752, DOI 10.1001/jamainternmed.2015.4838
   Tsay SL, 2008, CANCER NURS, V31, P109, DOI 10.1097/01.NCC.0000305694.74754.7b
   World Cancer Research Fund Research American Institute for Cancer Research., 2017, Continuous Update Project Expert Report 2017. Diet, nutrition, physical activity and breast cancer
   Wyatt G, 2012, ONCOL NURS FORUM, V39, P568, DOI 10.1188/12.ONF.568-577
   Zavotsky Kathleen Evanovich, 2014, Clin J Oncol Nurs, V18, pE45, DOI 10.1188/14.CJON.E45-E49
   Zhao TJ, 2010, P NATL ACAD SCI USA, V107, P7467, DOI 10.1073/pnas.1002271107
   Zhou KN, 2015, EUR J ONCOL NURS, V19, P54, DOI 10.1016/j.ejon.2014.07.010
   Zick SM, 2016, JAMA ONCOL, V2, P1470, DOI 10.1001/jamaoncol.2016.1867
   Zivkovic AM, 2011, CALIF AGR, V65, P106, DOI 10.3733/ca.v065n03p106
NR 79
TC 5
Z9 5
U1 3
U2 16
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2218-676X
EI 2219-6803
J9 TRANSL CANCER RES
JI Transl. Cancer Res.
PD APR
PY 2018
VL 7
SU 3
BP S379
EP S389
DI 10.21037/tcr.2018.02.06
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology
GA GF3IM
UT WOS:000431841600013
OA hybrid
DA 2026-01-16
ER

PT J
AU Hung, HH
   Chen, WC
   Chen, YH
   Chiu, LT
   Chen, HY
AF Hung, Hao-Hsiu
   Chen, Wen-Chi
   Chen, Yung-Hsiang
   Chiu, Lu-Ting
   Chen, Huey-Yi
TI Evaluation of the efficacy of Chinese herbal medicine and acupuncture
   for the prevention of mental disorders in interstitial cystitis patients
   A nationwide population-based study
SO MEDICINE
LA English
DT Article
DE anxiety; depression; insomnia; interstitial cystitis; bladder pain
   syndrome; National Health Insurance Research Database; traditional
   Chinese medicine
ID PAIN SYNDROME/INTERSTITIAL CYSTITIS; QUALITY-OF-LIFE; CANCER TYPE;
   BLADDER; DEPRESSION; PREVALENCE; ANXIETY; RISK; DIAGNOSIS; SYMPTOMS
AB Traditional Chinese medicine (TCM) is commonly used for urinary symptoms in Eastern countries. Since there are few effective treatments available for patients with interstitial cystitis/bladder pain syndrome (IC/BPS), the psychological burden leads to increased healthcare-seeking behavior. Some patients may therefore seek TCM treatment for related urinary symptoms. Due to limited clinical research evaluating the effects of TCM on IC/BPS, we conducted a nationwide population-based cohort study to investigate the relationship between TCM and mental disorders among these patients. The IC/BPS cohort and its matched non-IC/BPS comparison cohort were recruited from the National Health Insurance (NHI) Research Database between 2000 and 2011. Patients with the use of Chinese herbal medicine (CHM) granules or acupuncture over 90 days per year were enrolled as the TCM users. Multivariable Cox proportional hazards models were used to evaluate the hazard ratio (HR) of mental disorders related to interstitial cystitis. The incidence of mental disorders in the 2 cohorts was assessed with Kaplan-Meier curves. A total of 1123 patients with IC/BPS and 4492 matched non-IC/BPS subjects were included in this study. The IC/BPS cohort demonstrated higher incidence rate of mental disorders than the cohort without IC/BPS (adjusted HR: 2.21, 95% confidence interval [CI]: 1.73-2.81). There was no statistically significant difference in the risk of mental disorders between IC/BPS patients with and without CHM granules or acupuncture treatment (adjusted HR: 0.99, 95% CI: 0.58-1.68). Our results indicated that CHM and acupuncture showed insignificant efficacy in the prevention of mental disorders in IC/BPS patients.
C1 [Hung, Hao-Hsiu] Asia Univ, Dept Chinese Med, Taichung, Taiwan.
   [Chen, Wen-Chi; Chen, Yung-Hsiang; Chen, Huey-Yi] Asia Univ, Grad Inst Integrated Med, Coll Chinese Med, Taichung, Taiwan.
   [Chen, Wen-Chi; Chen, Yung-Hsiang; Chen, Huey-Yi] Asia Univ, Dept Obstet & Gynecol, Taichung, Taiwan.
   [Chen, Yung-Hsiang] Asia Univ, Coll Med & Hlth Sci, Dept Psychol, Taichung, Taiwan.
   [Chiu, Lu-Ting] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Chiu, Lu-Ting] China Med Univ, Coll Med, Taichung, Taiwan.
C3 Asia University Taiwan; Asia University Taiwan; Asia University Taiwan;
   Asia University Taiwan; China Medical University Taiwan; China Medical
   University Hospital - Taiwan; China Medical University Taiwan
RP Chen, HY (corresponding author), China Med Univ, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
EM d888208@ms45.hinet.net
RI ; Chen, Yung-Hsiang/K-6766-2015
OI 洪, 皓脩/0009-0000-7908-1242; Chen, Yung-Hsiang/0000-0002-8756-5113
FU Taiwan Ministry of Health and Welfare Clinical Trial Center, Taichung,
   Taiwan [MOHW109-TDU-B-212-114004]; MOST Clinical Trial Consortium for
   Stroke, Taichung, Taiwan [MOST 108-2321-B-039-003-]; Tseng-Lien Lin
   Foundation, Taichung, Taiwan; China Medical University, Taichung, Taiwan
   [DMR-109-085, CMU108-S-38]
FX This study is supported in part by Taiwan Ministry of Health and Welfare
   Clinical Trial Center (MOHW109-TDU-B-212-114004), MOST Clinical Trial
   Consortium for Stroke (MOST 108-2321-B-039-003-), Tseng-Lien Lin
   Foundation, and China Medical University (DMR-109-085 and CMU108-S-38),
   Taichung, Taiwan.
CR Baranowski AP, 2008, EUR UROL, V53, P33, DOI 10.1016/j.eururo.2007.10.010
   Berry SH, 2011, J UROLOGY, V186, P540, DOI 10.1016/j.juro.2011.03.132
   Chuang YC, 2015, INT UROL NEPHROL, V47, P275, DOI 10.1007/s11255-014-0908-6
   Ciaramella A, 2001, PSYCHO-ONCOLOGY, V10, P156, DOI 10.1002/pon.505
   Clemens JQ, 2005, J UROLOGY, V173, P98, DOI 10.1097/01.ju.0000146114.53828.82
   Fan YH, 2008, INT J UROL, V15, P416, DOI 10.1111/j.1442-2042.2008.02020.x
   Fietta Pierluigi, 2007, Acta Biomed, V78, P88
   Flores-Carreras O, 2015, TRANSL ANDROL UROL, V4, P620, DOI 10.3978/j.issn.2223-4683.2015.10.11
   FORRESTER AW, 1992, INT J PSYCHIAT MED, V22, P33, DOI 10.2190/CJ9D-32C2-8CM7-FT3D
   Gotoh A, 2004, J PHARMACOL SCI, V96, P115, DOI 10.1254/jphs.FPJ03098X
   Hanno PM, 2015, J UROLOGY, V193, P1545, DOI 10.1016/j.juro.2015.01.086
   Kajiwara Mitsuru, 2008, Hinyokika Kiyo, V54, P95
   Keller JJ, 2013, NEUROUROL URODYNAM, V32, P467, DOI 10.1002/nau.22316
   Keller JJ, 2012, BJU INT, V110, pE903, DOI 10.1111/j.1464-410X.2012.11539.x
   Konrad M, 2016, WORLD J CARDIOL, V8, P547, DOI 10.4330/wjc.v8.i9.547
   Laganà AS, 2017, INT J WOMENS HEALTH, V9, P323, DOI 10.2147/IJWH.S119729
   Lee WC, 2016, J ETHNOPHARMACOL, V184, P1, DOI 10.1016/j.jep.2015.12.026
   Linden W, 2012, J AFFECT DISORDERS, V141, P343, DOI 10.1016/j.jad.2012.03.025
   Michael YL, 2000, J UROLOGY, V164, P423, DOI 10.1016/S0022-5347(05)67376-4
   Nickel JC, 2010, J UROLOGY, V183, P167, DOI 10.1016/j.juro.2009.08.133
   O'Hare PG, 2013, INT UROGYNECOL J, V24, P977, DOI 10.1007/s00192-012-1966-x
   Pazin C, 2016, INT UROGYNECOL J, V27, P697, DOI 10.1007/s00192-015-2815-5
   Rothrock NE, 2002, J UROLOGY, V167, P1763, DOI 10.1016/S0022-5347(05)65195-6
   Rovner E, 2000, UROLOGY, V56, P940, DOI 10.1016/S0090-4295(00)00845-1
   Sönmez MG, 2017, GINEKOL POL, V88, P61, DOI 10.5603/GP.a2017.0013
   Thompson AE, 2016, BMC FAM PRACT, V17, DOI 10.1186/s12875-016-0440-0
   Troxel WM, 2014, J CLIN SLEEP MED, V10, P1331, DOI 10.5664/jcsm.4292
   Tsai CF, 2010, NEUROUROL URODYNAM, V29, P568, DOI 10.1002/nau.20799
   Wang H, 2012, NEUROSCI RES, V72, P43, DOI 10.1016/j.neures.2011.09.007
   Watkins KE, 2011, GEN HOSP PSYCHIAT, V33, P143, DOI 10.1016/j.genhosppsych.2011.01.004
   Yagi Hiroshi, 2016, J Tradit Complement Med, V6, P126, DOI [10.1016/j.jtcme.2014.11.021, 10.1016/j.jtcme.2014.11.021]
NR 31
TC 5
Z9 7
U1 1
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL 24
PY 2020
VL 99
IS 30
AR 21422
DI 10.1097/MD.0000000000021422
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA MY4WY
UT WOS:000558420900107
PM 32791761
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU de Barros, JC
   Valentim, LG
   Dias, RC
   Pereira, AHT
   Di Santis, GW
   Arias, MVB
AF de Barros, Juliana Campos
   Valentim, Larissa Garbelini
   Dias, Raira Costa
   Tanaka Pereira, Alfredo Hajime
   Di Santis, Giovana Wingeter
   Bahr Arias, Monica Vicky
TI Surgical Excision of an Osteochondroma in a Nerve Root of the Cauda
   Equina of a Dog
SO ACTA SCIENTIAE VETERINARIAE
LA Portuguese
DT Article
DE diseases; nervous system; neoplasms; spinal nerve roots
ID IMAGING DIAGNOSIS; EXTRADURAL CHONDROMA; CERVICAL-SPINE
AB Background: Spinal neoplasms are classified into extradural, in tradural/extramedullary or in tramedullary. Intradural/extramedullary tumors include meningiomas and nerve sheath tumors, which arise from meninges or peripheral nerves around the spinal cord. Clinical signs are related to dysfunction of the involved nerve and include pain, nerve root signature and atrophy. Osteochondromas are benign tumors located within the bone, on its surface or in extra-osseous regions, when they are classified as soft tissue osteochondoma. The aim of this study is to describe a case of an osteochondroma in a nervous root of the cauda equina in a dog, whose surgical resection allowed the resolution of the clinical signs.
   Case: A 12-year-old, male, Labrador Retriever dog, was presented with a 40-day history of progressive, painful, pelvic limb paresis, with no improvement when treated with analgesics and acupuncture. Neurological abnormalities included paraparesis, sometimes worse in the left pelvic limb, that was carried flexed at the level of the stifle, hindlimb atrophy, decreased interdigital reflexes and pain in the lumbar spinal region, mainly over L6 vertebra. Results of blood count and serum biochemical analysis were unremarkable. Computed tomography (CT) of the lumbosacral area was performed and the evaluation of images in transverse and reconstructed dorsal and sagittal planes allowed the visualization of a hyperattenuating and calcified round structure with 8 mm x 6 mm, in the left side of vertebral canal, at the level of caudal epiphysis of L6. Lumbosacral (L7-S1) CT abnormalities, as subchondral sclerosis, mild disc margin bulging, spondylosis deformans and foraminal proliferation were also observed but were considered clinically insignificant. Then, a dorsal 1.6 laminectomy was performed and after opening of the vertebral canal it was observed the presence of an ovoid mass, in the left side of the medullary cone, measuring approximately 0.9 cm in length, originating from a sacral nerve root. This structure was excised and submitted to histopathological evaluation. The dog improved after surgery without any complications, and neurological functions were gradually recovered. The histopathology of the mass was confirmed as an osteochondroma.
   Discussion: The history and neurologic examination findings as well the improvement after surgery were compatible with the lesion visualized by TC in L6, rather than the degenerative changes in L7-S1. Regarding the position of the mass, the main differential would be nerve sheath tumor, one of the most common types of primary neoplasia of the peripheral nervous system, however in a CT study in dogs with brachial plexus and nerve roots neoplasms, calcification of the tumor was not observed. Most of benign cartilaginous tumors of soft tissue are chondromas/osteochondromas, and this lesion should not be confused with multiple osteochondroma or multiple cartilaginous exostoses, which have been reported as multifocal, proliferative lesions involving the surface of ribs, vertebrae and pelvis of young dogs. If this lesion is unique, it is called osteochondroma. There are two reports of chondromas into the first lumbar vertebrae of dogs, with adherence to the floor of the vertebral canal and one report of an osteochondroma originated from the left pedicle of T11 in a cat. Radiculopathy and myelopathy caused by osteochondromas inside the spine are rare in humans and description of this tumor arising from nerve roots were not found in the veterinary literature. Probably the origin of the mass was metaplasia of the meninges surrounding the nervous root. In conclusion, neurological examination, CT and surgical exploration allowed the diagnosis and removal of a soft tissue osteochondroma, a rare benign tumor, with good patient recovery.
C1 [de Barros, Juliana Campos; Valentim, Larissa Garbelini; Dias, Raira Costa; Tanaka Pereira, Alfredo Hajime] MV Autonomo, Londrina, Parana, Brazil.
   [Di Santis, Giovana Wingeter] Univ Estadual Londrina UEL, Dept Med Vet Prevent, Londrina, Parana, Brazil.
   [Bahr Arias, Monica Vicky] Univ Estadual Londrina UEL, Dept Clin Vet, Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina
RP Arias, MVB (corresponding author), Univ Estadual Londrina UEL, Rodovia Celso Garcia Cid,Km 380 Caixa Postal 1001, BR-86051970 Londrina, Parana, Brazil.
EM vicky@uel.br
RI DiSantis, Giovana/OEP-1507-2025; Arias, Monica/G-9235-2012; VALENTIM,
   LARISSA/KWU-4871-2024
CR Amort KH, 2012, VET RADIOL ULTRASOUN, V53, P289, DOI 10.1111/j.1740-8261.2011.01903.x
   Bagley RS, 2010, VET CLIN N AM-SMALL, V40, P915, DOI 10.1016/j.cvsm.2010.05.010
   Besalti O, 2016, J VET SCI, V17, P225, DOI 10.4142/jvs.2016.17.2.225
   Braund K.G., 2003, Clinical Neurology in Small Animals: Localization, Diagnosis and Treatment
   Engel S, 2014, VET RADIOL ULTRASOUN, V55, P305, DOI 10.1111/vru.12066
   Evans HE, 2013, MILLERS ANATOMY DOG
   Fletcher ChristopherDM., 2002, PATHOLOGY GENETICS T, V4
   Gaetani P, 1996, SURG NEUROL, V46, P534, DOI 10.1016/S0090-3019(96)00226-1
   Green EM, 1999, VET RADIOL ULTRASOUN, V40, P634, DOI 10.1111/j.1740-8261.1999.tb00891.x
   Heblinski Nikola, 2017, JFMS Open Rep, V3, p2055116916688397, DOI [10.1177/2055116916688397, 10.1177/2055116916688397]
   Kahveci R, 2012, ACTA ORTHOP TRAUMATO, V46, P468, DOI 10.3944/AOTT.2012.2599
   Lin ZJ, 2013, J SPINAL DISORD TECH, V26, P194, DOI 10.1097/BSD.0b013e31823eb239
   Marinho PVT, 2014, ARQ BRAS MED VET ZOO, V66, P1323, DOI 10.1590/1678-7157
   Meij BP, 2010, VET CLIN N AM-SMALL, V40, P983, DOI 10.1016/j.cvsm.2010.05.006
   Meuten D.J., 2016, Tumors in domestic animals
   Natale Massimo, 2013, BMJ Case Rep, V2013, DOI 10.1136/bcr-2013-010142
   Ródenas S, 2008, VET RADIOL ULTRASOUN, V49, P464, DOI 10.1111/j.1740-8261.2008.00409.x
   Rudich SR, 2004, VET RADIOL ULTRASOUN, V45, P46, DOI 10.1111/j.1740-8261.2004.04007.x
   Sharp NJH., 2005, Small Animal Spinal Disorders - Diagnosis and Surgery, V2nd, DOI DOI 10.1016/B978-0-7234-3209-8.50015-7
   조현제, 2009, [Journal of the Korean Society of Radiology (JKSR), 대한영상의학회지], V60, P221
   Marinho PVT, 2013, SEMIN-CIENC AGRAR, V34, P1835, DOI 10.5433/1679-0359.2013v34n4p1835
   Wahle AM, 2017, VET RADIOL ULTRASOUN, V58, pE6, DOI 10.1111/vru.12372
NR 22
TC 0
Z9 0
U1 0
U2 7
PU UNIV FED RIO GRANDE DO SUL
PI PORTO ALEGRE RS
PA FAC VET, CAIXA POSTAL 15017, PORTO ALEGRE RS, 91501-570, BRAZIL
SN 1678-0345
EI 1679-9216
J9 ACTA SCI VET
JI Acta Sci. Vet.
PY 2018
VL 46
SU 1
AR 327
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA VJ5IA
UT WOS:000606326600076
DA 2026-01-16
ER

PT J
AU Valladales-Restrepo, LF
   Gaviria-Mendoza, A
   Machado-Duque, ME
   Prado-Echeverry, JA
   Cortes-Navarro, JL
   Machado-Alba, JE
AF Valladales-Restrepo, Luis Fernando
   Gaviria-Mendoza, Andres
   Machado-Duque, Manuel Enrique
   Prado-Echeverry, Julio Andres
   Cortes-Navarro, Jorge Luis
   Machado-Alba, Jorge Enrique
TI Chronic pain and continuity of analgesic treatment during the COVID-19
   pandemic
SO PAIN PRACTICE
LA English
DT Article
DE analgesics; opioid; chronic pain; COVID-19; pharmacoepidemiology;
   SARS-CoV-2
ID UNITED-STATES; IMPACT; INDIVIDUALS; TIME
AB IntroductionChronic pain can trigger both physical and mental health complications. During the COVID-19 pandemic, patients with chronic diseases have had reduced access to some medications. ObjectiveTo determine the pharmacological management of patients with chronic pain and its continuity during the COVID-19 pandemic. MethodsThis was a retrospective longitudinal study of the continuity of analgesic use in patients with chronic pain between September 1, 2019 and February 28, 2021 based on a drug dispensing database. Survival analysis was performed until the discontinuation of chronic analgesics. ResultsA total of 12,701 patients who were being treated for chronic pain were identified. Their median age was 70.3 years, and 74.4% were women. The pain of rheumatological origin was the most frequent etiology (46.1%); the most used medications were nonopioid analgesics (78.9%), pain modulators (24.8%) and opioid analgesics (23.3%). A total of 76.1% of the patients experienced interruptions in their management during the study period. The median time to the first interruption of treatment was 5.0 months (95% CI: 4.8-5.2). Those who were treated for oncological pain experienced a greater number of interruptions in their management. ConclusionsThe pharmacological management of patients with chronic pain is heterogeneous, and this real-world study showed that a high proportion of patients experienced an interruption of pain management during the 12 months following the onset of the COVID-19 pandemic.
C1 [Valladales-Restrepo, Luis Fernando; Gaviria-Mendoza, Andres; Machado-Duque, Manuel Enrique; Prado-Echeverry, Julio Andres; Cortes-Navarro, Jorge Luis; Machado-Alba, Jorge Enrique] Univ Tecnol Pereira Audifarma SA, Grp Invest Farmacoepidemiol & Farmacovigilancia, Pereira, Colombia.
   [Valladales-Restrepo, Luis Fernando; Gaviria-Mendoza, Andres; Machado-Duque, Manuel Enrique] Fdn Universitaria Autonoma Amer, Fac Med, Grp Invest Biomed, Pereira, Colombia.
   [Machado-Alba, Jorge Enrique] Univ Tecnol Pereira Audifarma SA, Grp Invest Farmacoepidemiol & Farmacovigilancia, Calle 105 14-140, Pereira 660003, Colombia.
C3 Universidad Tecnologica de Pereira; Universidad Tecnologica de Pereira
RP Machado-Alba, JE (corresponding author), Univ Tecnol Pereira Audifarma SA, Grp Invest Farmacoepidemiol & Farmacovigilancia, Calle 105 14-140, Pereira 660003, Colombia.
EM machado@utp.edu.co
OI Gaviria-Mendoza, Andrés/0000-0003-2500-7658; Valladales Restrepo, Luis
   Fernando/0000-0002-4245-0101; Machado-Alba, Jorge
   Enrique/0000-0002-8455-0936
CR Akazawa M, 2019, J PAIN RES, V12, P1631, DOI 10.2147/JPR.S203553
   Alonso-Matielo H, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.624154
   [Anonymous], DECR 457 2020 REP CO
   Bäckryd E, 2018, INT J WOMENS HEALTH, V10, P55, DOI 10.2147/IJWH.S142052
   Basu Saurav, 2020, Indian J Med Ethics, VV, P103, DOI [10.20529/ijme.2020.041, 10.20529/IJME.2020.041]
   Dahlhamer J, 2018, MMWR-MORBID MORTAL W, V67, P1001, DOI 10.15585/mmwr.mm6736a2
   de Moraes ÉB, 2021, PAIN MANAG NURS, V22, P103, DOI 10.1016/j.pmn.2020.11.010
   Díaz Cabezas Ricardo, 2009, Acta Med Colomb, V34, P96
   Fallach N, 2021, RHEUMATOL THER, V8, P1129, DOI 10.1007/s40744-021-00329-5
   Valladales-Restrepo LF, 2022, DRUGS-REAL WOR OUTC, V9, P487, DOI 10.1007/s40801-022-00318-2
   Fischer B, 2011, PHARMACOEPIDEM DR S, V20, P1269, DOI 10.1002/pds.2190
   Frazer JS, 2021, FAM MED COMMUNITY HE, V9, DOI 10.1136/fmch-2021-001143
   Galani A, 2021, SCI TOTAL ENVIRON, V798, DOI 10.1016/j.scitotenv.2021.149014
   Hruschak V, 2021, PAIN, V162, P619, DOI 10.1097/j.pain.0000000000002128
   Ingrasciotta Y, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0222836
   Javed S, 2020, PAIN MANAG, V10, P275, DOI 10.2217/pmt-2020-0035
   Kleinmann B, 2021, PAIN PHYSICIAN, V24, P165, DOI 10.36076/ppj.2021.24.165-173
   Lacasse A, 2021, PAIN REP, V6, DOI 10.1097/PR9.0000000000000891
   Lassen CL, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000025153
   Latina R, 2019, PAIN MANAG NURS, V20, P373, DOI 10.1016/j.pmn.2019.01.005
   Mullins CF, 2022, IRISH J MED SCI, V191, P7, DOI 10.1007/s11845-021-02509-2
   Mun CJ, 2021, PAIN MED, V22, P470, DOI 10.1093/pm/pnaa446
   Nieto R, 2020, J CLIN MED, V9, DOI 10.3390/jcm9113558
   Pagé MG, 2021, HEALTH PROMOT CHRON, V41, P141, DOI 10.24095/hpcdp.41.5.01
   Rikin S, 2022, J PRIM CARE COMMUNIT, V13, DOI 10.1177/21501319221076926
   Ruscitto A, 2015, EUR J PAIN, V19, P59, DOI 10.1002/ejp.520
   Serrano-Ibañez ER, 2021, BRIT J HEALTH PSYCH, V26, P544, DOI 10.1111/bjhp.12483
   Smyrnioti ME, 2021, J PAIN RES, V14, P2571, DOI 10.2147/JPR.S323568
   Ushida T, 2019, EXPERT OPIN PHARMACO, V20, P2041, DOI 10.1080/14656566.2019.1651840
   Vaduganathan M, 2020, JAMA-J AM MED ASSOC, V323, P2524, DOI 10.1001/jama.2020.9184
   Zambelli Z, 2022, J HEALTH PSYCHOL, V27, P1099, DOI 10.1177/1359105321995962
   Ziadé N, 2020, INT J RHEUM DIS, V23, P1550, DOI 10.1111/1756-185X.13960
NR 32
TC 3
Z9 5
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1530-7085
EI 1533-2500
J9 PAIN PRACT
JI Pain Pract.
PD APR
PY 2023
VL 23
IS 4
BP 359
EP 367
DI 10.1111/papr.13197
EA DEC 2022
PG 9
WC Anesthesiology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA C9KJ4
UT WOS:000901396300001
PM 36514870
DA 2026-01-16
ER

PT J
AU Molinares, D
   Kurtevski, S
   Zhu, YR
AF Molinares, Diana
   Kurtevski, Sara
   Zhu, Yingrong
TI Chemotherapy-Induced Peripheral Neuropathy: Diagnosis, Agents, General
   Clinical Presentation, and Treatments
SO CURRENT ONCOLOGY REPORTS
LA English
DT Review
DE Chemotherapy; Neuropathy; Cancer rehabilitation; CIPN; Survivorship
ID DOUBLE-BLIND; TOPICAL AMITRIPTYLINE; REDUCED GLUTATHIONE; PILOT TRIAL;
   PREVENTION; PAIN; MANAGEMENT; CANCER; NEUROTOXICITY; ACUPUNCTURE
AB Purpose of ReviewThis review aims to discuss pathophysiology, diagnosis, clinical presentation, and treatment of chemotherapy-induced peripheral neuropathy. Agent-specific presentation and pathophysiology is also being discussed.Recent FindingsAs new systemic oncological treatments continue to be developed, the number of cancer survivors continues to grow. Survivors are living longer with the long-term side effects of oncological treatments. We reviewed the pathophysiology of agent-specific chemotherapy-induced peripheral neuropathy and the updates in its treatment and preventative tools.SummaryChemotherapy-induced peripheral neuropathy is a debilitating long-term side effect that often impairs cancer survivors' function and quality of life. The increasing life expectancy of cancer survivors has resulted in increased prevalence of this condition. Understanding its intricacies can provide physicians with better treatment tools and research opportunities to develop or identify new therapeutic agents.
C1 [Molinares, Diana; Kurtevski, Sara; Zhu, Yingrong] Univ Miami, Miller Sch Med, Dept Phys Med & Rehabil, 1611 NW 12th Ave, Miami, FL 33136 USA.
C3 University of Miami
RP Molinares, D (corresponding author), Univ Miami, Miller Sch Med, Dept Phys Med & Rehabil, 1611 NW 12th Ave, Miami, FL 33136 USA.
EM dmolinares@med.miami.edu
CR Anand P, 2011, BRIT J ANAESTH, V107, P490, DOI 10.1093/bja/aer260
   Anand P, 2019, J PAIN RES, V12, P2039, DOI 10.2147/JPR.S213912
   Argyriou AA, 2014, CANCER MANAG RES, V6, P135, DOI 10.2147/CMAR.S44261
   Bailey AG, 2021, J ONCOL PHARM PRACT, V27, P156, DOI 10.1177/1078155220959431
   Burgess J, 2021, ONCOL THER, V9, P385, DOI 10.1007/s40487-021-00168-y
   Cascinu S, 2002, J CLIN ONCOL, V20, P3478, DOI 10.1200/JCO.2002.07.061
   CASCINU S, 1995, J CLIN ONCOL, V13, P26, DOI 10.1200/JCO.1995.13.1.26
   Chow R, 2023, BMJ SUPPORT PALLIAT, V13, P27, DOI 10.1136/spcare-2022-003815
   D'Souza RS, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10081909
   De Andrade DC, 2017, ONCOLOGIST, V22, P1154, DOI 10.1634/theoncologist.2017-0235
   Dimitrova A, 2017, J ALTERN COMPLEM MED, V23, P164, DOI 10.1089/acm.2016.0155
   Durand JP, 2012, ANN ONCOL, V23, P200, DOI 10.1093/annonc/mdr045
   Ege E, 2023, PAIN PRACT, V23, P793, DOI 10.1111/papr.13259
   Ernst Edzard, 2010, J Pain Symptom Manage, V40, pe3, DOI 10.1016/j.jpainsymman.2010.03.010
   Gee NS, 1996, J BIOL CHEM, V271, P5768, DOI 10.1074/jbc.271.10.5768
   Gewandter JS, 2019, SUPPORT CARE CANCER, V27, P1765, DOI 10.1007/s00520-018-4424-6
   Gewandter JS, 2014, SUPPORT CARE CANCER, V22, P1807, DOI 10.1007/s00520-014-2158-7
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Hamity MV, 2017, PAIN, V158, P962, DOI 10.1097/j.pain.0000000000000862
   Hammack JE, 2002, PAIN, V98, P195, DOI 10.1016/S0304-3959(02)00047-7
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   Huang CC, 2021, J CLIN MED, V10, DOI 10.3390/jcm10163694
   Izgu N, 2019, EUR J ONCOL NURS, V40, P36, DOI 10.1016/j.ejon.2019.03.002
   Izycki D, 2016, GINEKOL POL, V87, P516, DOI 10.5603/GP.2016.0036
   Jongen JLM, 2015, J NEURO-ONCOL, V121, P229, DOI 10.1007/s11060-014-1632-x
   Kautio AL, 2008, J PAIN SYMPTOM MANAG, V35, P31, DOI 10.1016/j.jpainsymman.2007.02.043
   Kautio AL, 2009, ANTICANCER RES, V29, P2601
   Kerckhove N, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00086
   Kurt S, 2018, EUR J ONCOL NURS, V32, P12, DOI 10.1016/j.ejon.2017.11.001
   Leal AD, 2014, CANCER-AM CANCER SOC, V120, P1890, DOI 10.1002/cncr.28654
   Li T, 2021, NEUROL SCI, V42, P4109, DOI 10.1007/s10072-021-05576-6
   Loprinzi C, 2020, SUPPORT CARE CANCER, V28, P1183, DOI 10.1007/s00520-019-04881-3
   Loprinzi CL, 2020, J CLIN ONCOL, V38, DOI 10.1200/JCO.20.01399
   Lu WD, 2020, ONCOLOGIST, V25, P310, DOI 10.1634/theoncologist.2019-0489
   Lu WD, 2010, CURR TREAT OPTION ON, V11, P141, DOI 10.1007/s11864-010-0126-0
   Lynch ME, 2014, J PAIN SYMPTOM MANAG, V47, P166, DOI 10.1016/j.jpainsymman.2013.02.018
   Lynch ME, 2005, J PAIN, V6, P644, DOI 10.1016/j.jpain.2005.04.008
   Madsen ML, 2019, CANCER CHEMOTH PHARM, V84, P471, DOI 10.1007/s00280-019-03884-5
   Moore RA, 2015, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD008242.pub3, 10.1002/14651858.CD008659.pub3]
   Rahn EJ, 2009, NEUROTHERAPEUTICS, V6, P713, DOI 10.1016/j.nurt.2009.08.002
   Rao RD, 2007, CANCER-AM CANCER SOC, V110, P2110, DOI 10.1002/cncr.23008
   Rodrigues-Amorim D, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.554899
   Rostock M, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/349653
   Saarto T, 2010, J NEUROL NEUROSUR PS, V81, P1372, DOI 10.1136/jnnp.2008.144964
   Saif MW, 2010, ANTICANCER RES, V30, P2927
   Salat K, 2020, PHARMACOL REP, V72, P508, DOI 10.1007/s43440-020-00106-1
   Schloss JM, 2015, SUPPORT CARE CANCER, V23, P1843, DOI 10.1007/s00520-015-2725-6
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Smith TJ, 2020, J PALLIAT CARE, V35, P53, DOI 10.1177/0825859719827589
   Smith T, 2007, VASC HEALTH RISK MAN, V3, P833
   Solomon LR, 2016, SUPPORT CARE CANCER, V24, P3489, DOI 10.1007/s00520-016-3175-5
   Staff NP, 2019, J PERIPHER NERV SYST, V24, pS26, DOI 10.1111/jns.12335
   Staff NP, 2017, ANN NEUROL, V81, P772, DOI 10.1002/ana.24951
   Timmins HC, 2020, SUPPORT CARE CANCER, V28, P4459, DOI 10.1007/s00520-020-05299-y
   Timmins HC, 2020, CLIN NEUROPHYSIOL, V131, P1979, DOI 10.1016/j.clinph.2020.02.028
   Tofthagen CS, 2020, CURR ONCOL REP, V22, DOI 10.1007/s11912-020-00903-0
   van Haren F, 2022, CANCER REP-US, V5, DOI 10.1002/cnr2.1577
   WIERNIK PH, 1992, CANCER INVEST, V10, P1, DOI 10.3109/07357909209032783
   Wiffen Philip J, 2017, Cochrane Database Syst Rev, V6, pCD007938, DOI 10.1002/14651858.CD007938.pub4
   Zajaczkowska R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061451
   Zhang SM, 2021, SEMIN ONCOL, V48, P193, DOI 10.1053/j.seminoncol.2021.09.004
   Zimmerman C, 2016, SUPPORT CARE CANCER, V24, P1071, DOI 10.1007/s00520-015-2876-5
NR 62
TC 10
Z9 13
U1 1
U2 17
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3790
EI 1534-6269
J9 CURR ONCOL REP
JI Curr. Oncol. Rep.
PD NOV
PY 2023
VL 25
IS 11
BP 1227
EP 1235
DI 10.1007/s11912-023-01449-7
EA SEP 2023
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA X2QC8
UT WOS:001094589900001
PM 37702983
DA 2026-01-16
ER

PT J
AU Xu, Y
   Chen, YT
   Feng, YF
   Zhang, Q
   Zhou, T
   Wo, CX
   Zhang, MM
AF Xu, Yun
   Chen, Yunting
   Feng, Yongfu
   Zhang, Qian
   Zhou, Tao
   Wo, Chunxin
   Zhang, Minmin
TI Silver needle thermal conduction therapy relieves pain in rats with
   myofascial pain syndrome
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Myofascial pain syndrome; silver needle thermal conduction therapy;
   chronic pain; acupuncture effect; thermal effect
ID GENE-RELATED PEPTIDE; 5-HT3
AB Objective: To assess the effects of silver needle thermal conduction therapy on spinal neurotransmitter activation and inflammation reduction in the myofascial trigger point musculature of a rat model with myofascial pain syndrome (MPS). Methods: The MPS rat model was induced by a combination of impact and exercise fatigue. MPS rats were then subjected to silver needle thermal conduction therapy for 14 days. Thermal and mechanical pain thresholds were assessed using the thermal hyperalgesia and mechanical hyperalgesia tests. Transverse and longitudinal sections of the right medial thigh muscle were prepared for histological analysis using HE staining. Western blot and immunohistochemistry were used to measure the expression of calcitonin gene-related peptide (CGRP), substance P (SP), and 5-hydroxytryptamine (5-HT) in the L4-6 segment of the spinal cord. Additionally, the levels of inflammatory cytokines, including interleukin 1-(3 (IL-1(3) and tumor necrosis factor alpha (TNF-alpha), in the right medial femoral muscle were assessed via ELISA. Results: MPS rats exhibited a decreased thermal and mechanical pain threshold compared to control rats. Muscle fiber atrophy and deformation were observed in the MPS rats. Levels of IL-1(3 and TNF-alpha were elevated in the right medial femoral muscle, while CGRP and SP expression were increased, and 5-HT expression was decreased in the spinal cord. Silver needle thermal conduction therapy effectively reversed these pathological changes in the MPS rats. Conclusions: Silver needle thermal conduction therapy alleviated MPS in rats by modulating spinal neurotransmitter expression and reducing muscle inflammation.
C1 [Xu, Yun; Feng, Yongfu; Zhang, Qian; Zhou, Tao] Guizhou Med Univ, Affiliated Hosp 2, Dept Pain, Kaili 556000, Guizhou, Peoples R China.
   [Chen, Yunting; Wo, Chunxin; Zhang, Minmin] Guizhou Med Univ, Affiliated Hosp, Dept Pain, 28 Guiyi St, Guiyang 550004, Guizhou, Peoples R China.
C3 Guizhou Medical University; Guizhou Medical University
RP Wo, CX; Zhang, MM (corresponding author), Guizhou Med Univ, Affiliated Hosp, Dept Pain, 28 Guiyi St, Guiyang 550004, Guizhou, Peoples R China.
EM wochunxin@163.com; zmm1987@hotmail.com
RI Zhang, Minmin/KLD-3502-2024; Zhou, Tao/OVZ-1004-2025
FU Guizhou Province Science and Technology Planning Project [ZK [2021]];
   National Natural Science Foundation of China [82160226]; Regional
   Foundation of China;  [Qianke He Foundation-ZK [2023] Key 044]
FX -ZK [2021] , Guizhou Province Science and Technology Planning Project;
   82160226, National Natural Science Foundation of China, Regional
   Foundation of China; and Guizhou Province Science and Technology Plan
   Project (Grants No: Qianke He Foundation-ZK [2023] Key 044) .r -ZK
   [2021] , Guizhou Province Science and Technology Planning Project;
   82160226, National Natural Science Foundation of China, Regional
   Foundation of China; and Guizhou Province Science and Technology Plan
   Project (Grants No: Qianke He Foundation-ZK [2023] Key 044) .
CR Barbero M, 2019, CURR OPIN SUPPORT PA, V13, P270, DOI 10.1097/SPC.0000000000000445
   Chang WH, 2021, BIOMED J, V44, P739, DOI 10.1016/j.bj.2020.05.020
   Corum M, 2021, COMPLEMENT THER CLIN, V43, DOI 10.1016/j.ctcp.2021.101319
   Baltazar MCD, 2022, BMC WOMENS HEALTH, V22, DOI 10.1186/s12905-022-01910-y
   de Magalhaes SF, 2021, EUR J NEUROSCI, V53, P376, DOI 10.1111/ejn.14985
   Duarte FCK, 2023, CLIN J PAIN, V39, P188, DOI 10.1097/AJP.0000000000001102
   Fan AY, 2017, CHIN J INTEGR MED, V23, P83, DOI 10.1007/s11655-017-2800-6
   Fernández-de-las-Peñas C, 2023, LIFE-BASEL, V13, DOI 10.3390/life13030694
   Fernández-de-Las-Peñas C, 2019, J PAIN RES, V12, P1899, DOI 10.2147/JPR.S154728
   Fernández-Lázaro D, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020501
   Galasso A, 2020, CURR PAIN HEADACHE R, V24, DOI 10.1007/s11916-020-00877-5
   Green DP, 2019, NEURON, V101, P412, DOI 10.1016/j.neuron.2019.01.012
   Iyengar S, 2017, PAIN, V158, P543, DOI 10.1097/j.pain.0000000000000831
   Lauritano D, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054811
   Lee S, 2022, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.947884
   Li CJ, 2022, MOL NEUROBIOL, V59, P7253, DOI 10.1007/s12035-022-03034-8
   Lu FY, 2023, J PAIN RES, V16, P1025, DOI 10.2147/JPR.S401875
   Lv XL, 2022, NEUROL INDIA, V70, pS288, DOI 10.4103/0028-3886.360917
   Mansoori SS, 2021, J REHABIL MED, V53, DOI 10.2340/16501977-2781
   Menéndez-Torre A, 2023, CHIROPR MAN THER, V31, DOI 10.1186/s12998-023-00489-x
   Paige C, 2022, J NEUROSCI, V42, P1930, DOI 10.1523/JNEUROSCI.1137-21.2022
   Paoletta M, 2022, MEDICINA-LITHUANIA, V58, DOI 10.3390/medicina58081014
   Shah JP, 2008, ARCH PHYS MED REHAB, V89, P16, DOI 10.1016/j.apmr.2007.10.018
   Srinivasan M, 2022, PHYS MED REH CLIN N, V33, P307, DOI 10.1016/j.pmr.2022.01.011
   Taskesen F, 2023, CRANIO, V41, P96, DOI 10.1080/08869634.2020.1820686
   Urits I, 2020, BEST PRAC RES-CL ANA, V34, P427, DOI 10.1016/j.bpa.2020.08.003
   Wei S, 2021, J NEUROINFLAMM, V18, DOI 10.1186/s12974-021-02151-w
   Xiong JW, 2024, FRONT NEUROL, V15, DOI 10.3389/fneur.2024.1374542
   Yamaguchi C, 2021, BIOL PHARM BULL, V44, P1067, DOI 10.1248/bpb.b21-00178
   Yehoshua I, 2022, BMC PRIM CARE, V23, DOI 10.1186/s12875-022-01951-0
   Yuan Y, 2022, MOL PAIN, V18, DOI 10.1177/17448069221093016
   Zha MY, 2022, J MED CASE REP, V16, DOI 10.1186/s13256-021-03239-w
   Zhang Q, 2020, ARCH PHYS MED REHAB, V101, P1437, DOI 10.1016/j.apmr.2020.02.013
NR 33
TC 0
Z9 0
U1 2
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2025
VL 17
IS 4
BP 2604
EP 2613
DI 10.62347/QQBB3856
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 2GC3M
UT WOS:001481829200014
PM 40385020
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Zeng, YS
   Wang, C
   Ward, KE
   Hume, AL
AF Zeng, Yvette S.
   Wang, Connie
   Ward, Kristina E.
   Hume, Anne L.
TI Complementary and Alternative Medicine in Hospice and Palliative Care: A
   Systematic Review
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Review
DE Complementary therapy; alternative therapy; palliative care; hospice
   care; symptom management; review
ID QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; AROMATHERAPY MASSAGE;
   MUSIC-THERAPY; CANCER; PAIN; MANAGEMENT; INSTRUMENT; ANXIETY; PEOPLE
AB Context. The aim of palliative care is to improve quality of life for patients with serious illnesses by treating their symptoms and adverse effects. Hospice care also aims for this for patients with a life expectancy of six months or less. When conventional therapies do not provide adequate symptom management or produce their own adverse effects, patients, families, and caregivers may prefer complementary or alternative approaches in their care.
   Objectives. The objectives of this study were to evaluate the available evidence on the use of complementary or alternative medicine (CAM) in hospice and palliative care and to summarize their potential benefits.
   Methods. A defined search strategy was used in reviewing literature from major databases. Searches were conducted using base terms and the symptom in question. Symptoms included anxiety, pain, dyspnea, cough, fatigue, insomnia, nausea, and vomiting. Studies were selected for further evaluation based on relevancy and study type. References of systematic reviews were also assessed. After evaluation using quality assessment tools, findings were summarized and the review was structured based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
   Results. Out of 4682 studies, 17 were identified for further evaluation. Therapies included acupressure, acupuncture, aromatherapy massage, breathing, hypnotherapy, massage, meditation, music therapy, reflexology, and reiki. Many studies demonstrated a short-term benefit in symptom improvement from baseline with CAM, although a significant benefit was not found between groups.
   Conclusion. CAM may provide a limited short-term benefit in patients with symptom burden. Additional studies are needed to clarify the potential value of CAM in the hospice or palliative setting. (C) 2018 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Zeng, Yvette S.; Wang, Connie; Ward, Kristina E.; Hume, Anne L.] Univ Rhode Isl, Kingston, RI 02881 USA.
C3 University of Rhode Island
RP Hume, AL (corresponding author), Univ Rhode Isl, Coll Pharm, 7 Greenhouse Rd, Kingston, RI 02881 USA.
EM alhume@uri.edu
RI Ward, Kristina/AIB-1342-2022
CR [Anonymous], COMPL ALT INT WHATS
   [Anonymous], US COMPL HLTH APPR U
   [Anonymous], 2017, PALL CAR CANC
   [Anonymous], CONT HYPN INTEGR THE
   [Anonymous], PROSPEROCRD420170673
   [Anonymous], COMPL ALT THER HOSP
   [Anonymous], HPNA POS STAT COMPL
   Briggs M, 1999, J PAIN SYMPTOM MANAG, V18, P438, DOI 10.1016/S0885-3924(99)00092-5
   Bruera E, 1991, J Palliat Care, V7, P6
   Byock IR, 1998, PALLIATIVE MED, V12, P231, DOI 10.1191/026921698670234618
   COHEN SR, 1995, PALLIATIVE MED, V9, P207, DOI 10.1177/026921639500900306
   DEHAES JCJM, 1990, BRIT J CANCER, V62, P1034, DOI 10.1038/bjc.1990.434
   FISHMAN B, 1987, CANCER-AM CANCER SOC, V60, P1151, DOI 10.1002/1097-0142(19870901)60:5<1151::AID-CNCR2820600538>3.0.CO;2-G
   GRAHAM KY, 1987, CANCER NURS, V10, P338
   Gutgsell KJ, 2013, J PAIN SYMPTOM MANAG, V45, P822, DOI 10.1016/j.jpainsymman.2012.05.008
   Hodgson H, 2000, Nurs Stand, V14, P33
   Horne-Thompson A, 2008, J PALLIAT MED, V11, P582, DOI 10.1089/jpm.2007.0193
   Jadad AR, 1996, CONTROL CLIN TRIALS, V17, P1, DOI 10.1016/0197-2456(95)00134-4
   Johnson MJ, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0453-x
   Kutner JS, 2008, ANN INTERN MED, V149, P369, DOI 10.7326/0003-4819-149-6-200809160-00003
   Liberati Alessandro, 2009, PLoS Med, V6, pe1000100, DOI 10.1371/journal.pmed.1000100
   Lim JTW, 2011, ACUPUNCT MED, V29, P173, DOI 10.1136/aim.2011.004044
   Liossi C., 2001, Contemporary Hypnosis, V18, P145, DOI [10.1002/ch.228, DOI 10.1002/CH.228]
   López-Sendín N, 2012, J ALTERN COMPLEM MED, V18, P480, DOI 10.1089/acm.2011.0277
   Lundeberg T, 2008, ACUPUNCT MED, V26, P239, DOI 10.1136/aim.26.4.239
   Olson K, 2003, J PAIN SYMPTOM MANAG, V26, P990, DOI 10.1016/S0885-3924(03)00334-8
   Pan CX, 2000, J PAIN SYMPTOM MANAG, V20, P374, DOI 10.1016/S0885-3924(00)00190-1
   Paterson C, 1996, BRIT MED J, V312, P1016
   Perkins P, 2008, PALLIATIVE MED, V22, P193, DOI 10.1177/0269216307087144
   PORTENOY RK, 1994, EUR J CANCER, V30A, P1326, DOI 10.1016/0959-8049(94)90182-1
   Ross CSK, 2002, PALLIATIVE MED, V16, P544, DOI 10.1191/0269216302pm597xx
   SNYDERHALPERN R, 1987, RES NURS HEALTH, V10, P155, DOI 10.1002/nur.4770100307
   Soden K, 2004, PALLIATIVE MED, V18, P87, DOI 10.1191/0269216304pm874oa
   Speilberger C.D., 1983, Manual for the State-Trait Anxiety Inventory
   Ventola C Lee, 2010, P T, V35, P461
   Wilcock A, 2004, PALLIATIVE MED, V18, P287, DOI 10.1191/0269216304pm895oa
   Wilkie D J, 2000, Hosp J, V15, P31
   Wilkinson S, 1999, PALLIATIVE MED, V13, P409, DOI 10.1191/026921699678148345
   Williams Anna-Leila, 2005, J Palliat Med, V8, P939, DOI 10.1089/jpm.2005.8.939
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 40
TC 61
Z9 79
U1 1
U2 105
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD NOV
PY 2018
VL 56
IS 5
BP 781
EP +
DI 10.1016/j.jpainsymman.2018.07.016
PG 18
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA GX0EG
UT WOS:000447382000016
PM 30076965
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Pritchard, KT
   Baillargeon, J
   Lee, WC
   Raji, MA
   Kuo, YF
AF Pritchard, Kevin T.
   Baillargeon, Jacques
   Lee, Wei-Chen
   Raji, Mukaila A.
   Kuo, Yong-Fang
TI Trends in the Use of Opioids vs Nonpharmacologic Treatments in Adults
   With Pain, 2011-2019
SO JAMA NETWORK OPEN
LA English
DT Article
ID UNITED-STATES; HEALTH-CARE; BACK-PAIN; PRESCRIPTION; COMPLEMENTARY;
   ASSOCIATION; IMPROVEMENT; POPULATION; PREVALENCE; MANAGEMENT
AB IMPORTANCE Chronic pain prevalence among US adults increased between 2010 and 2019. Yet little is known about trends in the use of prescription opioids and nonpharmacologic alternatives in treating pain.
   OBJECTIVES To compare annual trends in the use of prescription opioids, nonpharmacologic alternatives, both treatments, and neither treatment; compare estimates for the annual use of acupuncture, chiropractic care, massage therapy, occupational therapy, and physical therapy; and estimate the association between calendar year and pain treatment based on the severity of pain interference.
   DESIGN, SETTING, AND PARTICIPANTS A serial cross-sectional analysis was conducted using the nationally representative Medical Expenditure Panel Survey to estimate the use of outpatient services by cancer-free adults with chronic or surgical pain between calendar years 2011 and 2019. Data analysis was performed from December 29, 2021, to August 5, 2022.
   EXPOSURES Calendar year (2011-2019) was the primary exposure.
   MAIN OUTCOMES AND MEASURES The association between calendar year and mutually exclusive pain treatments (opioid vs nonpharmacologic vs both vs neither treatment) was examined. A secondary outcome was the prevalence of nonpharmacologic treatments (acupuncture, chiropractic care, massage therapy, occupational therapy, and physical therapy). All analyses were stratified by pain type.
   RESULTS Among the unweighted 46 420 respondents, 9643 (20.4% weighted) received surgery and 36 777 (79.6% weighted) did not. Weighted percentages indicated that 41.7% of the respondents were aged 45 to 64 years and 55.0% were women. There were significant trends in the use of pain treatments after adjusting for demographic factors, socioeconomic status, health conditions, and pain severity. For example, exclusive use of nonpharmacologic treatments increased in 2019 for both cohorts (chronic pain: adjusted odds ratio [aOR], 2.72; 95% CI, 2.30-3.21; surgical pain: a OR, 1.53; 95% CI, 1.13-2.08) compared with 2011. The use of neither treatment decreased in 2019 for both cohorts (chronic pain: aOR, 0.43; 95% CI, 0.37-0.49; surgical pain: aOR. 0.59; 95% CI, 0.46-0.75) compared with 2011. Among nonpharmacologic treatments, chiropractors and physical therapists were the most common licensed healthcare professionals.
   CONCLUSIONS AND RELEVANCE Among cancer-free adults with pain, the annual prevalence of nonpharmacologic pain treatments increased and the prevalent use of neither opioids nor nonpharmacologic therapy decreased for both chronic and surgical pain cohorts. These findings suggest that, although access to outpatient nonpharmacologic treatments is increasing, more severe pain interference may inhibit this access.
C1 [Pritchard, Kevin T.] Univ Texas Med Branch, Sch Publ & Populat Hlth, Dept Nutr Metab & Rehabil Sci, 301 Univ Blvd, Galveston, TX 77555 USA.
   [Baillargeon, Jacques] Univ Texas Med Branch, Sch Publ & Populat Hlth, Dept Epidemiol, Galveston, TX 77555 USA.
   [Lee, Wei-Chen; Raji, Mukaila A.] Univ Texas Med Branch, Dept Internal Med, Galveston, TX 77555 USA.
   [Kuo, Yong-Fang] Univ Texas Med Branch, Sch Publ & Populat Hlth, Dept Biostat & Data Sci, Galveston, TX 77555 USA.
C3 University of Texas System; University of Texas Medical Branch
   Galveston; University of Texas System; University of Texas Medical
   Branch Galveston; University of Texas System; University of Texas
   Medical Branch Galveston; University of Texas System; University of
   Texas Medical Branch Galveston
RP Pritchard, KT (corresponding author), Univ Texas Med Branch, Sch Publ & Populat Hlth, Dept Nutr Metab & Rehabil Sci, 301 Univ Blvd, Galveston, TX 77555 USA.
EM ktpritch@utmb.edu
OI Pritchard, Kevin/0000-0002-3836-2440; Lee, Wei Chen/0000-0003-4333-5444
FU National Institute on Drug Abuse [R01DA039192]; National Institute on
   Aging [P30-AG024832]; Agency for Healthcare Research and Quality
   [T32HS026133]; National Center for Complementary and Integrative Health
   [F31AT011856]; Agency for Healthcare Research and Quality [T32HS026133]
   Funding Source: NIH RePORTER; National Center for Complementary and
   Integrative Health [F31AT011856] Funding Source: NIH RePORTER; National
   Institute on Aging [P30AG024832] Funding Source: NIH RePORTER; National
   Institute on Drug Abuse [R01DA039192] Funding Source: NIH RePORTER
FX This study was supported with funding from the National Institute on
   Drug Abuse (grant R01DA039192), the National Institute on Aging (grant
   P30-AG024832), the Agency for Healthcare Research and Quality (grant
   T32HS026133), and the National Center for Complementary and Integrative
   Health (grant F31AT011856).
CR Agency for Healthcare Research and Quality, 2021, MEPS HC 213A PRESCR
   Agency for Healthcare Research and Quality, 2021, AHRQ Pub. No. 22-0010
   Agency for Healthcare Research and Quality, 2020, MEPS HC-209: 2018 Full Year Consolidated Data File
   [Anonymous], 2005, Empowering the IT Workforce, DHS IT Human Capital Strategic Plan (2005-2010), Draft Final for Discussion Purposes
   Bausell RB, 2001, MED CARE, V39, P190, DOI 10.1097/00005650-200102000-00009
   Bednarczyk M, 2020, J ACUTE CARE PHYS TH, V11, P54, DOI 10.1097/JAT.0000000000000115
   Bernard Didem, 2019, Research Findings No. 43
   Caldwell JT, 2016, AM J PUBLIC HEALTH, V106, P1463, DOI 10.2105/AJPH.2016.303212
   Candon M, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2021.42509
   Centers for Disease Control and Prevention US Department of Health Human Services, 2018, CALC TOT DAIL DOS OP
   Centers for Medicare and Medicaid Services, 2020, DEC MEM AC CHR LOW B
   Chevan J, 2011, J ORTHOP SPORT PHYS, V41, P467, DOI 10.2519/jospt.2011.3637
   Chou R.Hartung., 2020, Comparative Effectiveness Review, V229
   Chowdhury SadeqR., 2013, A comparison of taylor linearization and balanced repeated replication methods for variance estimation in medical expenditure panel survey
   Chowdhury SR., 2019, Methodology Report #33 Internet
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   Dahlhamer J.M., 2021, Prescription opioid use among adults with chronic pain: United States, 2019
   Dahlhamer J, 2018, MMWR-MORBID MORTAL W, V67, P1001, DOI 10.15585/mmwr.mm6736a2
   Davis MA, 2012, SPINE, V37, P1693, DOI 10.1097/BRS.0b013e3182541f45
   DeRigne L, 2016, HEALTH AFFAIR, V35, P520, DOI 10.1377/hlthaff.2015.0965
   Dowell D, 2016, JAMA-J AM MED ASSOC, V315, P1624, DOI 10.1001/jama.2016.1464
   Drug Enforcement Administration Department of Justice, 2014, Fed Regist, V79, P49661
   Duca LM, 2022, J PAIN, V23, P1492, DOI 10.1016/j.jpain.2022.02.013
   Eisenberg DM, 1998, JAMA-J AM MED ASSOC, V280, P1569, DOI 10.1001/jama.280.18.1569
   Encinosa W, 2022, INT J HEALTH ECON MA, V22, P1, DOI 10.1007/s10754-021-09307-4
   Esechie A, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-053487
   Feldman DE, 2020, J PAIN, V21, P869, DOI 10.1016/j.jpain.2019.11.014
   Fulton-Kehoe D, 2020, J PUBLIC HEALTH MAN, V26, P206, DOI 10.1097/PHH.0000000000001067
   Gaskin DJ, 2012, J PAIN, V13, P715, DOI 10.1016/j.jpain.2012.03.009
   Groenewald CB, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2021.46697
   Hawk C, 2012, PREV MED, V54, P18, DOI 10.1016/j.ypmed.2011.07.002
   Herman PM, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-001046
   Heyward J, 2018, JAMA NETW OPEN, V1, DOI 10.1001/jamanetworkopen.2018.3044
   Hill S., 2014, OUTPATIENT PRESCRIPT
   Iqbal S.U., 2007, The Veterans RAND 12 Item Health Survey (VR-12): what it is and how it is used, P1
   Karmali RN, 2021, HEALTH SERV RES, V56, P275, DOI 10.1111/1475-6773.13561
   Karmali RN, 2020, MED CARE, V58, P433, DOI 10.1097/MLR.0000000000001299
   Kennedy J, 2014, J PAIN, V15, P979, DOI 10.1016/j.jpain.2014.05.009
   Kuo YF, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.15638
   Lee B, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.38453
   Lee Wei-Chen, 2020, Tex J Health Syst Pharm, V19, P46
   Liaw V, 2020, PUBLIC HEALTH REP, V135, P114, DOI 10.1177/0033354919892638
   Medical Expenditure Panel Survey Medical Provider Component (MEPS-MPC), 2021, METH REP 2019 DAT CO
   Michigan Opioid Prescribing Engagement Network (OPEN), 2021, OP PRESCR REC
   Muench J, 2022, J AM BOARD FAM MED, V35, P352, DOI 10.3122/jabfm.2022.02.210306
   Nahin RL, 2019, J PAIN, V20, P796, DOI 10.1016/j.jpain.2019.01.003
   Nahin Richard L, 2016, NCHS Data Brief, P1
   Nahin RL, 2016, MAYO CLIN PROC, V91, P1292, DOI 10.1016/j.mayocp.2016.06.007
   National Academics of Sciences Enginering and Medicine Health and Medicine Division Board on Global Health Board on Health Sciences Policy Global Forum on Innovation in Health Professional Education Forum on Neuroscience and Nervous System Disorders, 2019, ROL NONPH APPR PAIN
   National Pain Strategy Task Force, NIH
   Navathe AS, 2017, JAMA INTERN MED, V177, P214, DOI 10.1001/jamainternmed.2016.8263
   Neuman MD, 2019, LANCET, V393, P1547, DOI 10.1016/S0140-6736(19)30428-3
   Olfson M, 2020, HEALTH AFFAIR, V39, P146, DOI 10.1377/hlthaff.2019.00783
   Pollack SW, 2020, The Health Workforce Delivering Evidence-Based Non-Pharmacological Pain Management
   Pritchard KT, 2021, ARCH PHYS MED REHAB, V102, P1257, DOI 10.1016/j.apmr.2021.01.086
   Quinlan TAG, 2021, HEALTH SERV RES, V56, P1233, DOI 10.1111/1475-6773.13875
   Salz T, 2019, J CLIN ONCOL, V37, P1001, DOI 10.1200/JCO.18.00938
   Schweickert WD, 2009, LANCET, V373, P1874, DOI 10.1016/S0140-6736(09)60658-9
   Shah R, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-052057
   Sites BD, 2014, REGION ANESTH PAIN M, V39, P6, DOI 10.1097/AAP.0000000000000022
   Skelly AC., 2020, Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review Update, DOI [10.23970/ahrqepccer227, DOI 10.23970/AHRQEPCCER227, 10.23970/AHRQEPCCER227]
   Smith M, 2010, J MANIP PHYSIOL THER, V33, P562, DOI 10.1016/j.jmpt.2010.08.017
   Tedesco D, 2017, JAMA SURG, V152, DOI 10.1001/jamasurg.2017.2872
   Tian TY, 2013, J AM MED INFORM ASSN, V20, pE275, DOI 10.1136/amiajnl-2013-001856
   US Department of Health and Human Services, 2022, RED PROP AD CHRON PA
   Waljee JF, 2017, ANN SURG, V265, P728, DOI 10.1097/SLA.0000000000001904
   Wilson N, 2020, MMWR-MORBID MORTAL W, V69, P290, DOI 10.15585/mmwr.mm6911a4
   Zelaya Carla E, 2020, NCHS Data Brief, P1
NR 68
TC 37
Z9 42
U1 1
U2 8
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD NOV 7
PY 2022
VL 5
IS 11
AR e2240612
DI 10.1001/jamanetworkopen.2022.40612
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7A3KZ
UT WOS:000898360900003
PM 36342717
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Gupta, E
   Lopez, G
   Narayanan, S
   Tennison, JM
   Elahi, I
   de Moraes, AR
   Fellman, BM
   Bruera, E
AF Gupta, Ekta
   Lopez, Gabriel
   Narayanan, Santhosshi
   Tennison, Jegy M.
   Elahi, Imran
   Rozman de Moraes, Aline
   Fellman, Bryan M.
   Bruera, Eduardo
TI Frequency and Characteristics of Integrative Oncology Referrals for
   Patients With Cancer Receiving Inpatient Rehabilitation
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE integrative oncology; pain; massage; fatigue; cancer; patient-reported
   outcome measures; inpatients; referral and consultation; rehabilitation
ID MULTIDISCIPLINARY SYMPTOM CONTROL; ASSESSMENT SYSTEM; CARE; DISTRESS;
   PAIN; ACUPUNCTURE; INTENSITY; MOBILITY; MASSAGE
AB Background: Integrative Oncology (IO) interventions may decrease physical, psychological, and social distress related to cancer and its treatments. Little is known about the frequency and predictors of IO referral for symptom management for cancer rehabilitation inpatients. Methods: A retrospective review was performed of patients with cancer who underwent inpatient rehabilitation at a specialized tertiary cancer center from 5/2016 to 3/2020. Patient demographics and IO consultation details, including patient-reported outcome measures of symptom burden using ESAS-FS and functional status using the Activity Measure for Post-Acute Care "6 clicks," were extracted. Descriptive summary statistics and logistic regression were used to analyze the data. Results: Out of 1196 inpatient rehabilitation admissions, 100 (8.4%) were referred to IO. The Activity Measure for Post-Acute Care "6 clicks" basic mobility admission scores were significant at a 1-point difference between the intervention and control group (39.5 vs 40.8, P < .05); both scores equate to a >50% degree of functional impairment. Referred patients were younger (62, P = .02) and Hispanics or Latinos (P = .02). The top symptoms for IO consultation included pain (N = 73), integrative approach (N = 41), relaxation (N = 38), and stress/anxiety (N = 33). Patients who reported a baseline symptom score >= 1 in the ESAS-FS, had both statistically (P < .05) and clinically significant improvements (>= 1 point change) for pain, fatigue, well-being, anxiety, and sleep after massage therapy. Conclusion: Cancer rehabilitation inpatients were commonly referred to IO to address pain, with observed improvements across multiple symptoms with massage therapy. Lower mobility scores and younger patients received significantly higher referrals to IO. Larger trials are needed to characterize the effects of IO interventions on the inpatient rehabilitation of patients with cancer.
C1 [Gupta, Ekta; Lopez, Gabriel; Narayanan, Santhosshi; Tennison, Jegy M.; Rozman de Moraes, Aline; Fellman, Bryan M.; Bruera, Eduardo] Univ Texas MD Anderson Canc Ctr, Houston, TX USA.
   [Elahi, Imran] Univ Texas Austin, Austin, TX USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; University of Texas Austin
RP Gupta, E (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, 1515 Holcombe Blvd,Unit 1414, Houston, TX 77030 USA.
EM EGupta@mdanderson.org
RI Tennison, M.D., Jegy/HJA-8091-2022; Gupta, Ekta/JVD-6698-2023
OI Gupta Sharma, Ekta/0000-0003-1716-7803; Lopez,
   Gabriel/0000-0002-3685-0280
FU National Institutes of Health through M.D. Anderson's Cancer Center
   Support Grant [CA016672]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article:
   Statistical staff was partly supported by the National Institutes of
   Health through M.D. Anderson's Cancer Center Support Grant CA016672.
CR Bruera E, 2001, SUPPORT CARE CANCER, V9, P162, DOI 10.1007/s005200000172
   Bruera E, 1991, J Palliat Care, V7, P6
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   CLEELAND CS, 1994, NEW ENGL J MED, V330, P592, DOI 10.1056/NEJM199403033300902
   Delgado-Guay MO, 2016, PALLIAT SUPPORT CARE, V14, P341, DOI 10.1017/S147895151500108X
   Duong N, 2017, CRIT REV ONCOL HEMAT, V120, P210, DOI 10.1016/j.critrevonc.2017.11.011
   Fu JB, 2015, INT J THER REHABIL, V22, P517, DOI 10.12968/ijtr.2015.22.11.517
   Garcia MK, 2018, INTEGR CANCER THER, V17, P148, DOI 10.1177/1534735416685403
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Grant SJ, 2021, INTEGR CANCER THER, V20, DOI 10.1177/15347354211002253
   Greenlee Heather, 2014, Journal of the National Cancer Institute Monographs, P346, DOI 10.1093/jncimonographs/lgu041
   Guo Y, 2007, ARCH PHYS MED REHAB, V88, P891, DOI 10.1016/j.apmr.2007.03.032
   Heim ME, 2007, ONKOLOGIE, V30, P429, DOI 10.1159/000104097
   Hui D, 2017, J PAIN SYMPTOM MANAG, V53, P630, DOI 10.1016/j.jpainsymman.2016.10.370
   Hui D, 2016, J PAIN SYMPTOM MANAG, V51, P262, DOI 10.1016/j.jpainsymman.2015.10.004
   Jette DU, 2015, PHYS THER, V95, P758, DOI 10.2522/ptj.20140174
   Jette DU, 2014, PHYS THER, V94, P379, DOI 10.2522/ptj.20130199
   Le Danseur M, 2019, REHABIL NURS, V44, P29, DOI 10.1097/rnj.0000000000000102
   Lopez G, 2019, SUPPORT CARE CANCER, V27, P4207, DOI 10.1007/s00520-019-04713-4
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   NCPGiON, Cancer-related fatigue
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Riedl D, 2017, WIEN KLIN WOCHENSCHR, V129, P692, DOI 10.1007/s00508-017-1266-z
   Strasser F, 2004, J PAIN SYMPTOM MANAG, V27, P481, DOI 10.1016/j.jpainsymman.2003.10.011
   Tennison JM, 2021, J CANCER, V12, P5987, DOI 10.7150/jca.61010
   Tennison JM, 2021, JCO ONCOL PRACT, V17, P631, DOI 10.1200/OP.20.00919
   Vainio A, 1996, J PAIN SYMPTOM MANAG, V12, P3, DOI 10.1016/0885-3924(96)00042-5
   Walsh D, 2000, SUPPORT CARE CANCER, V8, P175, DOI 10.1007/s005200050281
   Watanabe SM, 2012, PSYCHO-ONCOLOGY, V21, P977, DOI 10.1002/pon.1996
   Weiss SC, 2001, LANCET, V357, P1311, DOI 10.1016/S0140-6736(00)04515-3
   Wilkinson S, 2008, J ADV NURS, V63, P430, DOI 10.1111/j.1365-2648.2008.04712.x
   Yennurajalingam S, 2013, PALLIAT SUPPORT CARE, V11, P473, DOI 10.1017/S1478951512000879
   Zhang YY, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000033939
NR 33
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2024
VL 23
AR 15347354241296810
DI 10.1177/15347354241296810
PG 9
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA L3J3F
UT WOS:001349711400001
PM 39498495
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Petran, EM
   Periferakis, A
   Troumpata, L
   Periferakis, AT
   Scheau, AE
   Badarau, IA
   Periferakis, K
   Caruntu, A
   Savulescu-Fiedler, I
   Sima, RM
   Calina, D
   Constantin, C
   Neagu, M
   Caruntu, C
   Scheau, C
AF Petran, Elena Madalina
   Periferakis, Argyrios
   Troumpata, Lamprini
   Periferakis, Aristodemos-Theodoros
   Scheau, Andreea-Elena
   Badarau, Ioana Anca
   Periferakis, Konstantinos
   Caruntu, Ana
   Savulescu-Fiedler, Ilinca
   Sima, Romina-Marina
   Calina, Daniela
   Constantin, Carolina
   Neagu, Monica
   Caruntu, Constantin
   Scheau, Cristian
TI Capsaicin: Emerging Pharmacological and Therapeutic Insights
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Review
DE capsaicin; bioavailability; physiopathology; anti-cancer effects; local
   effects; adverse effects
ID VANILLOID RECEPTOR TRPV1; TRADITIONAL CHINESE MEDICINE; POSTMASTECTOMY
   PAIN SYNDROME; PLACEBO-CONTROLLED TRIAL; EPIDERMAL NERVE-FIBERS;
   GASTRIC-CANCER CELLS; TOPICAL CAPSAICIN; SUBSTANCE-P; DOUBLE-BLIND;
   SOMATOSTATIN ANALOGS
AB Capsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already has a number of established clinical and industrial applications. Capsaicin is known to act through the TRPV1 receptor, which exists in various tissues; capsaicin is hepatically metabolised, having a half-life correlated with the method of application. Research on various applications of capsaicin in different formulations is still ongoing. Thus, local capsaicin applications have a pronounced anti-inflammatory effect, while systemic applications have a multitude of different effects because their increased lipophilic character ensures their augmented bioavailability. Furthermore, various teams have documented capsaicin's anti-cancer effects, proven both in vivo and in vitro designs. A notable constraint in the therapeutic effects of capsaicin is its increased toxicity, especially in sensitive tissues. Regarding the traditional applications of capsaicin, apart from all the effects recorded as medicinal effects, the application of capsaicin in acupuncture points has been demonstrated to be effective and the combination of acupuncture and capsaicin warrants further research. Finally, capsaicin has demonstrated antimicrobial effects, which can supplement its anti-inflammatory and anti-carcinogenic actions.
C1 [Petran, Elena Madalina] Carol Davila Univ Med & Pharm, Dept Biochem, Bucharest 050474, Romania.
   [Petran, Elena Madalina] Grigore Alexandrescu Emergency Childrens Hosp, Dept Toxicol, Bucharest 011743, Romania.
   [Periferakis, Argyrios; Troumpata, Lamprini; Periferakis, Aristodemos-Theodoros; Badarau, Ioana Anca; Caruntu, Constantin; Scheau, Cristian] Carol Davila Univ Med & Pharm, Dept Physiol, Bucharest 050474, Romania.
   [Periferakis, Argyrios; Periferakis, Konstantinos] Akadimia Ancient Greek & Tradit Chinese Med, Athens 16675, Greece.
   [Periferakis, Argyrios; Periferakis, Aristodemos-Theodoros] Elkyda Res & Educ Ctr Charismatheia, Athens 17675, Greece.
   [Scheau, Andreea-Elena] Fundeni Clin Inst, Dept Radiol & Med Imaging, Bucharest 022328, Romania.
   [Periferakis, Konstantinos] Pan Hellen Org Educ Programs POEP, Athens 17236, Greece.
   [Caruntu, Ana] Carol Davila Cent Mil Emergency Hosp, Dept Oral & Maxillofacial Surg, Bucharest 010825, Romania.
   [Caruntu, Ana] Titu Maiorescu Univ, Fac Dent Med, Dept Oral & Maxillofacial Surg, Bucharest 031593, Romania.
   [Savulescu-Fiedler, Ilinca] Carol Davila Univ Med & Pharm, Dept Internal Med, Bucharest 050474, Romania.
   [Savulescu-Fiedler, Ilinca] Coltea Clin Hosp, Dept Internal Med & Cardiol, Bucharest 030167, Romania.
   [Sima, Romina-Marina] Carol Davila Univ Med & Pharm, Dept Obstet & Gynecol, Bucharest 020021, Romania.
   [Sima, Romina-Marina] Saint John Hosp, Bucur Matern, Bucharest 040294, Romania.
   [Calina, Daniela] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova 200349, Romania.
   [Constantin, Carolina; Neagu, Monica] Victor Babes Natl Inst Pathol, Immunol Dept, Bucharest 050096, Romania.
   [Constantin, Carolina; Neagu, Monica] Colentina Univ Hosp, Dept Pathol, Bucharest 020125, Romania.
   [Neagu, Monica] Univ Bucharest, Fac Biol, Bucharest 76201, Romania.
   [Caruntu, Constantin] Prof NC Paulescu Natl Inst Diabet Nutr & Metab Dis, Dept Dermatol, Bucharest 011233, Romania.
   [Scheau, Cristian] Foisor Clin Hosp, Orthopaed & Traumatol & Osteoarticular TB, Dept Radiol & Med Imaging, Bucharest 021382, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Institutul Clinic Fundeni; Titu Maiorescu
   University; Carol Davila University of Medicine & Pharmacy; Carol Davila
   University of Medicine & Pharmacy; University of Medicine & Pharmacy of
   Craiova; Victor Babes National Institute of Pathology; University of
   Bucharest
RP Scheau, C (corresponding author), Carol Davila Univ Med & Pharm, Dept Physiol, Bucharest 050474, Romania.; Savulescu-Fiedler, I (corresponding author), Carol Davila Univ Med & Pharm, Dept Internal Med, Bucharest 050474, Romania.; Savulescu-Fiedler, I (corresponding author), Coltea Clin Hosp, Dept Internal Med & Cardiol, Bucharest 030167, Romania.; Scheau, C (corresponding author), Foisor Clin Hosp, Orthopaed & Traumatol & Osteoarticular TB, Dept Radiol & Med Imaging, Bucharest 021382, Romania.
EM ilinca.savulescu@umfcd.ro; cristian.scheau@umfcd.ro
RI ; Petran, Madalina/GXG-6553-2022; Periferakis, Argyrios/AAV-2686-2020;
   Troumpata, Lamprini/OEN-7308-2025; Sima, Romina-Marina/AFW-2733-2022;
   Periferakis, Aristodemos-Theodoros/G-7707-2018; Neagu,
   Monica/C-3240-2011; Calina, Daniela/I-5509-2017; Scheau,
   Cristian/AAC-3378-2021; Caruntu, Ana/ABF-9311-2020; SAVULESCU-FIEDLER,
   ILINCA/NJT-0185-2025
OI Periferakis, Konstantinos/0000-0002-8919-2840; Petran,
   Madalina/0000-0002-6721-9328; Periferakis, Argyrios/0000-0002-8319-7464;
   Troumpata, Lamprini/0009-0008-7388-1466; Sima,
   Romina-Marina/0000-0002-9541-3347; Periferakis,
   Aristodemos-Theodoros/0000-0001-5827-3181; Neagu,
   Monica/0000-0001-9339-2805; Calina, Daniela/0000-0002-1523-9116; Scheau,
   Cristian/0000-0001-7676-6393; Caruntu, Ana/0000-0003-4200-3069; 
FU Ministry of Research, Innovation, and Digitization, CCCDI-UEFISCDI; 
   [PN-III-P2-2.1-PED-2021-2243]
FX This work was partially supported by a grant from the Ministry of
   Research, Innovation, and Digitization, CCCDI-UEFISCDI, project number
   PN-III-P2-2.1-PED-2021-2243, within PNCDI III.
CR Abdel-Salam OME, 2020, NEUROCHEM RES, V45, P1045, DOI 10.1007/s11064-020-02979-3
   Adaszek L, 2019, RES VET SCI, V123, P14, DOI 10.1016/j.rvsc.2018.12.002
   Adetunji TL, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.908487
   Agarwal A, 2005, ANAESTHESIA, V60, P1185, DOI 10.1111/j.1365-2044.2005.04402.x
   Agoons BB, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.11147
   Aguilar-Meléndez A, 2021, FOODS, V10, DOI 10.3390/foods10102502
   Aguilar-Melndez A., 2018, Los Chiles Que le Dan Sabor al Mundo: Contribuciones MULTIDISCIPLINARIAS
   Ahmady AR, 2023, J COLLOID INTERF SCI, V638, P616, DOI 10.1016/j.jcis.2023.01.139
   Akçay AB, 2009, TURK KARDIYOL DERN A, V37, P497
   Akhtar F, 2017, ACTA POL PHARM, V74, P321
   Alayza Escard F., 1992, Historia de la Cirugia en el Peru
   Alberti A, 2008, J PHYS CHEM A, V112, P5700, DOI 10.1021/jp801890g
   Alcorn JB., 1984, HUASTEC MAYAN ETHNOB
   Anandakumar P, 2008, BIOMED PHARMACOTHER, V62, P390, DOI 10.1016/j.biopha.2007.09.005
   Anantaworasakul P, 2020, MOLECULES, V25, DOI 10.3390/molecules25235575
   Anantaworasakul P, 2020, PHARMACEUTICS, V12, DOI 10.3390/pharmaceutics12050463
   Andrews J., 1995, Peppers - The Domesticated Capsicums
   Arora R., 2011, International Journal of Pharmaceutical Sciences and Drug Research, V3, P280
   Arruda-Vasconcelos R, 2023, INT ENDOD J, V56, P827, DOI 10.1111/iej.13922
   Arunprasert K, 2022, EUR J PHARM SCI, V173, DOI 10.1016/j.ejps.2022.106169
   Athanasiou A, 2007, BIOCHEM BIOPH RES CO, V354, P50, DOI 10.1016/j.bbrc.2006.12.179
   Augustin HG, 2017, SCIENCE, V357, DOI 10.1126/science.aal2379
   Ayiomamitis Georgios D, 2014, Oncoscience, V1, P457
   Babbar S, 2009, THER DRUG MONIT, V31, P502, DOI 10.1097/FTD.0b013e3181a8b200
   Bae S, 2018, POL J VET SCI, V21, P789, DOI 10.24425/pjvs.2018.125599
   Bai H, 2011, CARCINOGENESIS, V32, P1689, DOI 10.1093/carcin/bgr191
   Bangar SP, 2023, CRIT REV FOOD SCI, V63, P9580, DOI 10.1080/10408398.2022.2067121
   Bao ZQ, 2019, CELL CYCLE, V18, P1379, DOI 10.1080/15384101.2019.1618119
   Baron R, 2017, CURR MED RES OPIN, V33, P1401, DOI 10.1080/03007995.2017.1322569
   BARTHO L, 1985, NEUROSCIENCE, V16, P1, DOI 10.1016/0306-4522(85)90043-0
   BARTOLD PM, 1994, J PERIODONTOL, V65, P1113, DOI 10.1902/jop.1994.65.12.1113
   Basith S, 2016, MOLECULES, V21, DOI 10.3390/molecules21080966
   Basu S.K., 2003, Capsicum, P21
   Baudoin T, 2000, ACTA OTO-LARYNGOL, V120, P307, DOI 10.1080/000164800750001143
   Bauelos N., 2008, Estud. Soc, V16, P177
   Baxter M, 2014, THORAX, V69, P1080, DOI 10.1136/thoraxjnl-2014-205467
   Baz RA, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57080832
   Behbehani JM, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24021046
   Behrens M, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.881177
   Benítez-Angeles M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103421
   BERGER A, 1995, J PAIN SYMPTOM MANAG, V10, P243, DOI 10.1016/0885-3924(94)00130-D
   BERGREN DR, 1988, AM J PHYSIOL, V254, pR845, DOI 10.1152/ajpregu.1988.254.5.R845
   Bhagwat DA, 2021, J PHARM SCI-US, V110, P280, DOI 10.1016/j.xphs.2020.10.020
   Bortolotti M, 2011, DIGEST DIS SCI, V56, P3288, DOI 10.1007/s10620-011-1740-9
   Botonis PG, 2019, SCAND J MED SCI SPOR, V29, P171, DOI 10.1111/sms.13317
   Brandt MR, 2012, PHARMACEUTICALS, V5, P114, DOI 10.3390/ph5020114
   Breedlove D.E., 1993, The flowering of man: A Tzotzil botany of Zinacantan I II
   BRENEMAN DL, 1992, J AM ACAD DERMATOL, V26, P91, DOI 10.1016/0190-9622(92)70013-6
   BRODIN E, 1981, ACTA PHYSIOL SCAND, V112, P305, DOI 10.1111/j.1748-1716.1981.tb06821.x
   Brown KC, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010243
   Bucholz C F., 1816, Alm oder Taschenb fur Scheidekunstler und Apotheker, V37, P1
   Buitimea-Cantúa GV, 2020, J ENVIRON SCI HEAL B, V55, P835, DOI 10.1080/03601234.2020.1787758
   BURKS TF, 1985, FED PROC, V44, P2531
   Busker RW, 1998, AM J FOREN MED PATH, V19, P309, DOI 10.1097/00000433-199812000-00003
   Caballero J, 2022, J ENZYM INHIB MED CH, V37, P2169, DOI 10.1080/14756366.2022.2110089
   Carmack RobertM., 2016, The Legacy of Mesoamerica: History and Culture of a Native American Civilization
   Caruntu C, 2014, ACTA ENDOCRINOL-BUCH, V10, P545, DOI 10.4183/aeb.2014.545
   Caruntu C, 2015, FARMACIA, V63, P487
   Caruntu C, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/105950
   Caruntu C, 2012, J BIOMED OPT, V17, DOI 10.1117/1.JBO.17.8.085003
   Casanueva B, 2013, RHEUMATOL INT, V33, P2665, DOI 10.1007/s00296-012-2490-5
   Cassano R, 2022, PHARMACEUTICS, V14, DOI 10.3390/pharmaceutics14081593
   Castillo E, 2007, BIOCHEM BIOPH RES CO, V356, P424, DOI 10.1016/j.bbrc.2007.02.144
   Caterina MJ, 2000, SCIENCE, V288, P306, DOI 10.1126/science.288.5464.306
   Caterina MJ, 1997, NATURE, V389, P816, DOI 10.1038/39807
   Chan TC, 2021, BIOMED PHARMACOTHER, V141, DOI 10.1016/j.biopha.2021.111950
   Chanda S, 2008, DRUG METAB DISPOS, V36, P670, DOI 10.1124/dmd.107.019240
   Chang AY, 2016, RESP RES, V17, DOI 10.1186/s12931-016-0378-8
   Chang HC, 2011, HUM EXP TOXICOL, V30, P1657, DOI 10.1177/0960327110396530
   Chapa-Oliver AM, 2016, MOLECULES, V21, DOI 10.3390/molecules21080931
   Chemin Bassler H., 2000, Recetario Pame de San Luis Potos y Quertaro
   Chen B, 2023, J PAIN RES, V16, P1197, DOI 10.2147/JPR.S398393
   Chen D, 2012, INT J UROL, V19, P662, DOI 10.1111/j.1442-2042.2012.02981.x
   Chen FX, 2023, CYTOKINE, V165, DOI 10.1016/j.cyto.2023.156186
   Chen KX, 2019, FOOD CHEM, V283, P611, DOI 10.1016/j.foodchem.2019.01.078
   Chen KS, 2015, CHEM-BIOL INTERACT, V228, P35, DOI 10.1016/j.cbi.2015.01.007
   Chen MJ, 2021, DRUG DES DEV THER, V15, P125, DOI 10.2147/DDDT.S269901
   Chen Y, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e15290
   Cheng P, 2023, PHARMACOL RES, V188, DOI 10.1016/j.phrs.2022.106643
   Cheng YF, 2022, IUCRJ, V9, P4, DOI 10.1107/S2052252521013488
   CHESHIRE WP, 1990, PAIN, V42, P307, DOI 10.1016/0304-3959(90)91143-7
   Chiou KL, 2014, ECON BOT, V68, P190, DOI 10.1007/s12231-014-9270-y
   Cho H, 2020, FOOD SCI NUTR, V8, P4611, DOI 10.1002/fsn3.1785
   Chow J, 2007, BBA-MOL CELL RES, V1773, P565, DOI 10.1016/j.bbamcr.2007.01.001
   Chrubasik S, 2010, PHYTOTHER RES, V24, P1877, DOI 10.1002/ptr.3335
   Cianchetti C, 2010, INT J CLIN PRACT, V64, P457, DOI 10.1111/j.1742-1241.2009.02294.x
   Cleary D, 2022, J FAM PRACTICE, V71, P176, DOI 10.12788/jfp.0403
   Contri RV, 2014, INT J NANOMED, V9, P951, DOI 10.2147/IJN.S56579
   Cook Suzanne., 2016, FOREST LACANDON MAYA, DOI 10.1007/978-1-4614-9111-8
   CORDELL GA, 1993, ANN PHARMACOTHER, V27, P330, DOI 10.1177/106002809302700316
   COSTA M, 1986, PROG BRAIN RES, V68, P217, DOI 10.1016/S0079-6123(08)60241-1
   Coste B, 2010, SCIENCE, V330, P55, DOI 10.1126/science.1193270
   COWLES RS, 1989, J CHEM ECOL, V15, P719, DOI 10.1007/BF01014714
   Cruz F, 2004, UROLOGY, V63, P65, DOI 10.1016/j.urology.2003.11.001
   Cui SF, 2023, INSECTS, V14, DOI 10.3390/insects14010027
   Cumo Christopher., 2015, The Ongoing Columbian Exchange: Stories of Biological and Economic Transfer in World History
   D'Urso O, 2021, EUR J PHARMACOL, V910, DOI 10.1016/j.ejphar.2021.174480
   Dafni A, 2020, ECON BOT, V74, P330, DOI 10.1007/s12231-019-09477-w
   Dai NG, 2018, ONCOL REP, V40, P3235, DOI 10.3892/or.2018.6754
   Das J., 2018, International Journal of Research and Analytical Reviews, V5, P717
   De Feo V, 2004, ECON BOT, V58, pS221, DOI 10.1663/0013-0001(2004)58[S221:TRUOBS]2.0.CO;2
   de Gamboa PedroSarmiento., 2007, The History of the Incas
   Medina-Contreras JMD, 2020, J SCI FOOD AGR, V100, P3212, DOI 10.1002/jsfa.10357
   Reyes-Escogido MD, 2011, MOLECULES, V16, P1253, DOI 10.3390/molecules16021253
   de Sèze M, 2004, J UROLOGY, V171, P251, DOI 10.1097/01.ju.0000100385.93801.d4
   De Witt D.B. P. W., 2009, The complete chile pepper book: A gardener's guide to choosing, growing, preserving, and cooking
   Derry S, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008609.pub2
   DeVane CL, 2001, PHARMACOTHERAPY, V21, P1061, DOI 10.1592/phco.21.13.1061.34612
   Dezieck L, 2017, CLIN TOXICOL, V55, P908, DOI 10.1080/15563650.2017.1324166
   Ding HP, 2023, DRUGS, V83, P771, DOI 10.1007/s40265-023-01878-5
   DINI D, 1993, PAIN, V54, P223, DOI 10.1016/0304-3959(93)90213-9
   DON PC, 1988, J AM ACAD DERMATOL, V18, P1135, DOI 10.1016/S0190-9622(88)80017-3
   Dong YW, 2019, BIOCHEM BIOPH RES CO, V516, P365, DOI 10.1016/j.bbrc.2019.06.039
   DONOFRIO P, 1991, ARCH INTERN MED, V151, P2225
   Dou FF, 2023, EXP CELL RES, V433, DOI 10.1016/j.yexcr.2023.113856
   Dragos D, 2022, PLANTS-BASEL, V11, DOI 10.3390/plants11212991
   Dragosloveanu CDM, 2020, INT OPHTHALMOL, V40, P3547, DOI 10.1007/s10792-020-01544-9
   DRAY A, 1992, LIFE SCI, V51, P1759, DOI 10.1016/0024-3205(92)90045-Q
   Du GH, 2016, ADV PHARMACOL, V75, P325, DOI 10.1016/bs.apha.2016.01.001
   Du Q, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01064
   Du XN, 2013, CURR NEUROPHARMACOL, V11, P621, DOI 10.2174/1570159X113119990042
   Duarte Y, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.01040
   Dux M, 2003, J PHYSIOL-LONDON, V552, P859, DOI 10.1113/jphysiol.2003.050633
   Earley S, 2022, PHYSIOL REV, V102, P1153, DOI 10.1152/physrev.00057.2021
   EDVINSSON L, 1983, CELL TISSUE RES, V234, P1
   ELLIS CN, 1993, J AM ACAD DERMATOL, V29, P438, DOI 10.1016/0190-9622(93)70208-B
   EPSTEIN JB, 1994, ORAL SURG ORAL MED O, V77, P135, DOI 10.1016/0030-4220(94)90275-5
   Ercan N, 2013, INFLAMMOPHARMACOLOGY, V21, P413, DOI 10.1007/s10787-013-0175-7
   Eshbaugh WH, 2012, PEPPERS: BOTANY, PRODUCTION AND USES, P14, DOI 10.1079/9781845937676.0014
   ESHBAUGH WH, 1975, B TORREY BOT CLUB, V102, P396, DOI 10.2307/2484766
   EVERS BM, 1991, ANN SURG, V213, P190, DOI 10.1097/00000658-199103000-00002
   Fan Y, 2021, BRAIN BEHAV IMMUN, V91, P683, DOI 10.1016/j.bbi.2020.08.016
   Fiedor J, 2014, NUTRIENTS, V6, P466, DOI 10.3390/nu6020466
   Figini M, 1996, BRIT J PHARMACOL, V117, P1270, DOI 10.1111/j.1476-5381.1996.tb16725.x
   Forrester MB, 2022, CLIN TOXICOL, V60, P348, DOI 10.1080/15563650.2021.1966028
   Frei B, 1998, J ETHNOPHARMACOL, V62, P149, DOI 10.1016/S0378-8741(98)00051-8
   Frey E, 2018, ENEURO, V5, DOI 10.1523/ENEURO.0095-18.2018
   Frias B, 2016, MOLECULES, V21, DOI 10.3390/molecules21060797
   Friedman JR, 2019, ADV CANCER RES, V144, P263, DOI 10.1016/bs.acr.2019.05.002
   Friedman JR, 2017, BIOCHEM PHARMACOL, V129, P54, DOI 10.1016/j.bcp.2017.01.004
   FROESCHNER EH, 1992, J NEUROSURG, V76, P550, DOI 10.3171/jns.1992.76.3.0550
   Froidevaux S, 2002, BIOPOLYMERS, V66, P161, DOI 10.1002/bip.10256
   FruchtPery J, 1997, ACTA OPHTHALMOL SCAN, V75, P311
   Ganguly S., 2017, ARC J. Public Health Community Med., V2, P6, DOI DOI 10.20431/2456-0596.0201002
   Geck MS, 2017, J ETHNOPHARMACOL, V198, P499, DOI 10.1016/j.jep.2017.01.027
   GEPPETTI P, 1993, BRIT J PHARMACOL, V108, P646, DOI 10.1111/j.1476-5381.1993.tb12855.x
   Gharat LA, 2008, EXPERT OPIN THER PAT, V18, P159, DOI 10.1517/13543776.18.2.159
   Ghita MA, 2017, ACTA DERMATOVENER CR, V25, P223
   Gilardini Montani MS, 2015, NUTRITION, V31, P578, DOI 10.1016/j.nut.2014.05.005
   Gooding SMD, 2010, INT J DERMATOL, V49, P858, DOI 10.1111/j.1365-4632.2010.04537.x
   Goodwin B, 2023, PAIN MANAG, V13, P309, DOI 10.2217/pmt-2023-0006
   Gradinaru TC, 2022, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.751712
   Grieder T., 1988, La Galgada, Peru: A Preceramic Culture in Transition, P192
   Grüter T, 2020, J NEUROINFLAMM, V17, DOI 10.1186/s12974-020-01821-5
   Grushka M, 2002, AM FAM PHYSICIAN, V65, P615
   Guo RJ, 2023, J PAIN RES, V16, P141, DOI 10.2147/JPR.S395065
   Haak DC, 2012, P ROY SOC B-BIOL SCI, V279, P2012, DOI 10.1098/rspb.2011.2091
   HAGERMARK O, 1978, J INVEST DERMATOL, V71, P233, DOI 10.1111/1523-1747.ep12515092
   Hail N Jr, 2002, JNCI-J NATL CANCER I, V94, P1281, DOI 10.1093/jnci/94.17.1281
   Han TH, 2022, BIOMED PHARMACOTHER, V146, DOI 10.1016/j.biopha.2021.112500
   Hanson SM, 2015, BIOPHYS J, V108, P1425, DOI 10.1016/j.bpj.2015.02.013
   Harada N, 2007, GROWTH HORM IGF RES, V17, P171, DOI 10.1016/j.ghir.2006.12.005
   Harrison S, 2001, INT J BIOCHEM CELL B, V33, P555, DOI 10.1016/S1357-2725(01)00031-0
   Hauser-Kronberger C, 1997, REGUL PEPTIDES, V72, P79, DOI 10.1016/S0167-0115(97)01040-9
   Haverluk Terrence W., 2002, Journal for the Study of Food and Society, V6, P45, DOI [10.2752/152897902786732653, DOI 10.2752/152897902786732653]
   Hawkey CJ, 1999, LANCET, V353, P307, DOI 10.1016/S0140-6736(98)12154-2
   Hayman M., 2008, Current Anaesthesia and Critical Care, V19, P338, DOI [DOI 10.1016/J.CACC.2008.07.003, 10.1016/j.cacc.2008.07.003]
   He H, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1035702
   HEISER C B JR, 1969, Taxon, V18, P277, DOI 10.2307/1218828
   Helyes Z, 2000, NEUROSCI LETT, V278, P185, DOI 10.1016/S0304-3940(99)00936-2
   Hendel SK, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.822867
   Hoebart C, 2021, ACTA PHYSIOL, V232, DOI 10.1111/apha.13659
   Hoesli RC, 2021, OTO OPEN, V5, DOI 10.1177/2473974X211065668
   Hökfelt T, 2001, J INTERN MED, V249, P27, DOI 10.1046/j.0954-6820.2000.00773.x
   Howitt Michael R, 2020, Immunohorizons, V4, P23, DOI [10.4049/immunohorizons.1900099, 10.4049/immunohorizons.1900099]
   Hsu YJ, 2016, NUTRIENTS, V8, DOI 10.3390/nu8100648
   Hu XX, 2022, FOOD CHEM, V386, DOI 10.1016/j.foodchem.2022.132824
   Hudita A, 2021, MOLECULES, V26, DOI 10.3390/molecules26051455
   Hwang MK, 2010, CANCER RES, V70, P6859, DOI 10.1158/0008-5472.CAN-09-4393
   Iinuma T, 1996, BRIT J PLAST SURG, V49, P319, DOI 10.1016/S0007-1226(96)90163-0
   Ilie MA, 2019, EXP THER MED, V18, P916, DOI 10.3892/etm.2019.7513
   Inoue K, 2002, BIOCHEM BIOPH RES CO, V291, P124, DOI 10.1006/bbrc.2002.6393
   Ip SW, 2012, ENVIRON TOXICOL, V27, P332, DOI 10.1002/tox.20646
   Ira A., 2020, Legume Science, V2, DOI 10.1002/leg3.57
   irakli S., 2019, Trk. Pediatri. Arivi, V54, P53, DOI [10.14744/TurkPediatriArs.2019.52533, DOI 10.14744/TURKPEDIATRIARS.2019.52533]
   Irigoyen-Rascn F., 2015, Tarahumara Medicine: Ethnobotany and Healing among the Rarmuri of Mexico
   JANCSO G, 1987, ACTA PHYSIOL HUNG, V69, P295
   Járomi P, 2018, NEUROUROL URODYNAM, V37, P690, DOI 10.1002/nau.23376
   Jia G, 2020, BIOORG CHEM, V103, DOI 10.1016/j.bioorg.2020.104161
   Johnson MB, 2023, INFLAMMATION, V46, P256, DOI 10.1007/s10753-022-01731-z
   Johnson W, 2007, INT J TOXICOL, V26, P3, DOI 10.1080/10915810601163939
   Jorgensen MR, 2017, ACTA ODONTOL SCAND, V75, P130, DOI 10.1080/00016357.2016.1269191
   Jun HS, 2007, FOOD CHEM TOXICOL, V45, P708, DOI 10.1016/j.fct.2006.10.011
   Jung MY, 2001, CANCER LETT, V165, P139, DOI 10.1016/S0304-3835(01)00426-8
   Kamaruddin MF, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55070322
   Katsuragi H, 2011, ACTA BIOL HUNG, V62, P151, DOI 10.1556/ABiol.62.2011.2.5
   KAWADA T, 1984, TOXICOL APPL PHARM, V72, P449, DOI 10.1016/0041-008X(84)90121-2
   Khairatkar-Joshi N, 2009, TRENDS MOL MED, V15, P14, DOI 10.1016/j.molmed.2008.11.004
   Ki SY, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23179677
   Kim CS, 2004, J MED FOOD, V7, P267, DOI 10.1089/jmf.2004.7.267
   Kim HS, 2014, CARCINOGENESIS, V35, P1652, DOI 10.1093/carcin/bgu091
   Kim JH, 2018, ALLERGY ASTHMA IMMUN, V10, P187, DOI 10.4168/aair.2018.10.3.187
   Kim KS, 2002, ANESTH ANALG, V95, P1103, DOI 10.1097/00000539-200210000-00059
   Kim KS, 2006, ANESTH ANALG, V103, P709, DOI 10.1213/01.ane.0000228864.74691.9f
   Kim KS, 2009, ANESTH ANALG, V108, P992, DOI 10.1213/ane.0b013e318195b78f
   Kim S, 2014, NAT GENET, V46, P270, DOI 10.1038/ng.2877
   Kim YJ, 2016, SURV OPHTHALMOL, V61, P434, DOI 10.1016/j.survophthal.2016.01.002
   Kim-Katz SY, 2010, AM J EMERG MED, V28, P596, DOI 10.1016/j.ajem.2009.02.007
   Kimball BA, 2009, J CHEM ECOL, V35, P1461, DOI 10.1007/s10886-009-9721-6
   King J., 1909, Kings American Dispensatory, V1
   Klironomos S, 2014, REGUL PEPTIDES, V188, P5, DOI 10.1016/j.regpep.2013.11.002
   Kocak AO, 2020, AM J EMERG MED, V38, P1767, DOI 10.1016/j.ajem.2020.05.104
   Kohek M, 2021, INT J DRUG POLICY, V98, DOI 10.1016/j.drugpo.2021.103390
   Kolonko AK, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8090364
   Kort ME, 2012, PROGR MED CHEM, V51, P57, DOI 10.1016/B978-0-12-396493-9.00002-9
   Kosuge S., 1967, Nippon. Shokuhin Kogyo Gakkaishi, V14, P407, DOI [10.3136/nskkk1962.14.407, DOI 10.3136/NSKKK1962.14.407]
   Kouroumalis E, 2022, LIVERS-BASEL, V2, P315, DOI 10.3390/livers2040024
   Kouroumalis E, 2018, HEPATOMA RES, V4, P34, DOI 10.20517/2394-5079.2018.33
   Kozal K, 2021, CANCER CONTROL, V28, DOI 10.1177/10732748211041243
   Krishnatreyya H, 2018, EUR J PHARMACOL, V819, P114, DOI 10.1016/j.ejphar.2017.11.042
   Kuma V, 2021, AM J EMERG MED, V49, P343, DOI 10.1016/j.ajem.2021.06.049
   Kunjiappan S, 2021, NANOTECHNOLOGY, V32, DOI 10.1088/1361-6528/abc57e
   Kwon Y, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072461
   Kym PR, 2009, BIOCHEM PHARMACOL, V78, P211, DOI 10.1016/j.bcp.2009.02.014
   Lamberts SWJ, 2002, TRENDS ENDOCRIN MET, V13, P451, DOI 10.1016/S1043-2760(02)00667-7
   Lanning EP Pollard G., 1967, PERU INCAS
   Lassen CL, 2020, A A PRACT, V14, DOI 10.1213/XAA.0000000000001258
   Lau JK, 2014, APOPTOSIS, V19, P1190, DOI 10.1007/s10495-014-1007-y
   Laude-Pagniez Eulalie, 2022, JAAD Case Rep, V30, P70, DOI [10.1016/j.jdcr.2022.09.032, 10.1016/j.jdcr.2022.09.032]
   Laughlin R.M., 1969, Handbook of Middle American Indians, V7, P298
   Lauritano D, 2003, Minerva Stomatol, V52, P273
   Lazzeri M, 2004, UROL INT, V72, P145, DOI 10.1159/000075969
   Lechner A, 2021, PACE, V44, P548, DOI 10.1111/pace.14146
   Lee GR, 2013, OBESITY, V21, P115, DOI 10.1002/oby.20246
   Lee IO, 2007, HELICOBACTER, V12, P510, DOI 10.1111/j.1523-5378.2007.00521.x
   Lee JY, 2017, CANCER BIOTHER RADIO, V32, P169, DOI 10.1089/cbr.2017.2186
   Lee KJ, 2004, ALIMENT PHARM THER, V19, P415, DOI 10.1046/j.1365-2036.2004.01823.x
   Lee SH, 2012, J NUTR BIOCHEM, V23, P646, DOI 10.1016/j.jnutbio.2011.03.009
   Lee Tai Hee, 2000, Korean Journal of Internal Medicine, V15, P103
   Leibing E, 2002, PAIN, V96, P189, DOI 10.1016/S0304-3959(01)00444-4
   LEIBSOHN E, 1992, CUTIS, V49, P335
   Li SH, 2020, CHIN J NAT MEDICINES, V18, P28, DOI 10.1016/S1875-5364(20)30002-9
   Li YX, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-66900-2
   Liberti MV, 2016, TRENDS BIOCHEM SCI, V41, P211, DOI 10.1016/j.tibs.2015.12.001
   Lin CH, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-46
   Lin MH, 2016, MOLECULES, V21, DOI 10.3390/molecules21070849
   Lin YT, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18071343
   Lincoff NS, 1998, J NEURO-OPHTHALMOL, V18, P17
   Liu B, 2024, SEMIN CELL DEV BIOL, V155, P32, DOI 10.1016/j.semcdb.2023.07.011
   Liu L, 2001, J NEUROPHYSIOL, V85, P745, DOI 10.1152/jn.2001.85.2.745
   Liu T, 2016, BMC CANCER, V16, DOI 10.1186/s12885-016-2831-y
   Liu XY, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-16372-3
   Liu ZG, 2015, FOOD CHEM TOXICOL, V81, P1, DOI 10.1016/j.fct.2015.04.002
   Lo Vecchio S, 2021, EXP BRAIN RES, V239, P2873, DOI 10.1007/s00221-021-06170-0
   Lo YC, 2005, WORLD J GASTROENTERO, V11, P6254, DOI 10.3748/wjg.v11.i40.6254
   Long-Sols J., 2013, Capsicum y Cultura: La Historia Del Chilli
   Lorente Fernndez D., 2015, An. De Antropol, V49, P101, DOI [10.1016/S0185-1225(15)30005-9, DOI 10.1016/S0185-1225(15)30005-9]
   LOTTI T, 1994, J AM ACAD DERMATOL, V30, P232, DOI 10.1016/S0190-9622(94)70022-2
   Lpez Austin A., 1972, Estud. Cult. Nahuatl, V10, P129
   Lu MW, 2020, FOOD FUNCT, V11, P2848, DOI [10.1039/D0FO00351D, 10.1039/d0fo00351d]
   Lu SY, 2015, J ORAL FACIAL PAIN H, V29, P257, DOI 10.11607/ofph.1106
   Lu WW, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/9451670
   Luqman S, 2006, PHYTOTHER RES, V20, P303, DOI 10.1002/ptr.1861
   Lv L, 2017, BIOMED PHARMACOTHER, V91, P999, DOI 10.1016/j.biopha.2017.04.097
   Lysy J, 2003, GUT, V52, P1323, DOI 10.1136/gut.52.9.1323
   MACALPIN RN, 1980, CIRCULATION, V61, P296, DOI 10.1161/01.CIR.61.2.296
   Madero R.A., 2000, Recetario Totonaco de la Costa de Veracruz
   Magaña Alejandro Miguel Alberto, 2010, Polibotánica, P213
   MAGGI CA, 1995, PROG NEUROBIOL, V45, P1, DOI 10.1016/0301-0082(94)E0017-B
   Maihöfner CG, 2014, EUR J PAIN, V18, P671, DOI 10.1002/j.1532-2149.2013.00415.x
   Makhlough A, 2010, IRAN J KIDNEY DIS, V4, P137
   Maliszewska J, 2019, J ENVIRON SCI HEAL B, V54, P676, DOI 10.1080/03601234.2019.1632642
   Manzo E, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10020450
   Mao XL, 2018, MOL MED REP, V17, P6116, DOI 10.3892/mmr.2018.8574
   Marini E, 2015, FRONT MICROBIOL, V6, DOI 10.3389/fmicb.2015.01281
   MARKS DR, 1993, CEPHALALGIA, V13, P114, DOI 10.1046/j.1468-2982.1993.1302114.x
   MARKS JG, 1989, J AM ACAD DERMATOL, V21, P418, DOI 10.1016/S0190-9622(89)80050-7
   Marsella R, 2002, VET DERMATOL, V13, P131, DOI 10.1046/j.1365-3164.2002.00292.x
   Martínez-Aceviz Y, 2023, HEALTHCARE-BASEL, V11, DOI 10.3390/healthcare11223001
   Martnez T.H.L., 2007, Masters Thesis
   Mason L, 2004, BMJ-BRIT MED J, V328, P991, DOI 10.1136/bmj.38042.506748.EE
   Massot P.H., 2016, Australian Journal of Basic and Applied Sciences, V10, P148
   Matei AM, 2021, APPL SCI-BASEL, V11, DOI 10.3390/app11114915
   MATHIAS BJ, 1995, AM J PHYS MED REHAB, V74, P39, DOI 10.1097/00002060-199501000-00007
   Maurya VK, 2018, J SCI FOOD AGR, V98, P3492, DOI 10.1002/jsfa.8868
   Mavrommatis CI, 2012, PAIN, V153, P1720, DOI 10.1016/j.pain.2012.05.005
   MCCARTHY GM, 1992, J RHEUMATOL, V19, P604
   McCleane G, 2000, EUR J PAIN-LONDON, V4, P355, DOI 10.1053/eujp.2000.0200
   McGarvey LP, 2014, J ALLERGY CLIN IMMUN, V133, P704, DOI 10.1016/j.jaci.2013.09.016
   McKemy DD, 2002, NATURE, V416, P52, DOI 10.1038/nature719
   McNamara FN, 2005, BRIT J PHARMACOL, V144, P781, DOI 10.1038/sj.bjp.0706040
   McPartland FM, 2002, AM FAM PHYSICIAN, V65, P2211
   Meghvansi MK, 2010, J ETHNOPHARMACOL, V132, P1, DOI 10.1016/j.jep.2010.08.034
   Mehboob R, 2023, FRONT NEUROL, V14, DOI 10.3389/fneur.2023.1052811
   Menezes RD, 2022, ANTIBIOTICS-BASEL, V11, DOI 10.3390/antibiotics11091154
   Meotti FC, 2014, HANDB EXP PHARMACOL, V223, P1177, DOI 10.1007/978-3-319-05161-1_19
   Merritt JC, 2022, PHARMACOL THERAPEUT, V238, DOI 10.1016/j.pharmthera.2022.108177
   Micko K., 1898, Z. Unters. Nahr. Genussm, V1, P818, DOI [10.1007/BF02529190, DOI 10.1007/BF02529190]
   Micko K., 1899, Z. Unters. Nahr.-Und Genumittel Sowie Gebrauchsgegenstnde, V2, P411, DOI [10.1007/BF02529197, DOI 10.1007/BF02529197]
   Min JK, 2004, CANCER RES, V64, P644, DOI 10.1158/0008-5472.CAN-03-3250
   Misra MN, 2005, CAN J ANAESTH, V52, P485, DOI 10.1007/BF03016527
   Mistrova E, 2016, NEUROPEPTIDES, V58, P41, DOI 10.1016/j.npep.2015.12.005
   Mohapatra DP, 2005, J BIOL CHEM, V280, P13424, DOI 10.1074/jbc.M410917200
   Moirangthem SS, 2014, J FOOD SCI TECH MYS, V51, P1974, DOI 10.1007/s13197-012-0684-1
   Montiel-Oseguera A., 2013, La Persistencia de la Costumbre Pima. Interpretaciones Desde La Antropologa Cognitiva
   Mori A, 2006, CANCER RES, V66, P3222, DOI 10.1158/0008-5472.CAN-05-0087
   Movahed P, 2005, J BIOL CHEM, V280, P38496, DOI 10.1074/jbc.M507429200
   Mozsik Gyula, 2009, Inflammopharmacology, V17, P113, DOI 10.1007/s10787-009-0002-3
   Müller M, 2023, JPN DENT SCI REV, V59, P114, DOI 10.1016/j.jdsr.2023.02.005
   MUHIDDIN KA, 1994, POSTGRAD MED J, V70, P841, DOI 10.1136/pgmj.70.829.841
   Munjuluri S, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11010018
   Nabhan Gary Paul., 2016, Ethnobiology for the Future: Linking Cultural and Ecological Deiversity
   Nabhan GaryP., 2004, Why Some Like It Hot: Food, Genes, and Cultural Diversity
   Naves ER, 2019, TRENDS PLANT SCI, V24, P109, DOI 10.1016/j.tplants.2018.11.001
   Nawaka N, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232214299
   Nelson EK, 1919, J AM CHEM SOC, V41, P1115, DOI 10.1021/ja02228a011
   Nevo S, 2019, IMMUNOL LETT, V210, P1, DOI 10.1016/j.imlet.2019.02.003
   Nolano M, 1999, PAIN, V81, P135, DOI 10.1016/S0304-3959(99)00007-X
   Nunn N, 2010, J ECON PERSPECT, V24, P163, DOI 10.1257/jep.24.2.163
   O'Connor TM, 2004, J CELL PHYSIOL, V201, P167, DOI 10.1002/jcp.20061
   O'Leary CE, 2022, SCI IMMUNOL, V7, DOI 10.1126/sciimmunol.abj1080
   O'Leary CE, 2019, ANNU REV IMMUNOL, V37, P47, DOI 10.1146/annurev-immunol-042718-041505
   Ochoa-Alejo N, 2001, IN VITRO CELL DEV-PL, V37, P701, DOI 10.1007/s11627-001-0121-z
   Oyagbemi AA, 2010, INDIAN J CANCER, V47, P53, DOI 10.4103/0019-509X.58860
   Oz M, 2023, MED RES REV, V43, P1038, DOI 10.1002/med.21945
   Palsson-McDermott EM, 2013, BIOESSAYS, V35, P965, DOI 10.1002/bies.201300084
   Park HS, 2004, ANAESTHESIA, V59, P647, DOI 10.1111/j.1365-2044.2004.03739.x
   Park SY, 2014, MOL MED REP, V9, P499, DOI 10.3892/mmr.2013.1849
   Pasierski M, 2020, NEUROCHEM INT, V135, DOI 10.1016/j.neuint.2020.104709
   Patowary P, 2017, BIOMED PHARMACOTHER, V96, P1501, DOI 10.1016/j.biopha.2017.11.124
   PAYAN DG, 1989, ANNU REV MED, V40, P341
   Pearsall DM, 2008, HANDBOOK OF SOUTH AMERICAN ARCHAEOLOGY, P105, DOI 10.1007/978-0-387-74907-5_7
   Peel J, 2023, EUR J SPORT SCI, V23, P2038, DOI 10.1080/17461391.2023.2211966
   Peier AM, 2002, CELL, V108, P705, DOI 10.1016/S0092-8674(02)00652-9
   Periferakis A., 2019, P 15 INT C GEOL SOC, P702
   Periferakis A., 2019, P 15 INT C GEOL SOC, P700
   Periferakis A, 2024, BIOMIMETICS-BASEL, V9, DOI 10.3390/biomimetics9030154
   Periferakis A, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242216299
   Periferakis A, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232315054
   Periferakis A, 2019, BULL GEOL SOC GREECE, V55, P65, DOI 10.12681/bgsg.20997
   Periferakis A, 2021, ANAL CELL PATHOL, V2021, DOI 10.1155/2021/1840069
   Periferakis AT, 2023, NUTRIENTS, V15, DOI 10.3390/nu15194097
   Periferakis K, 2023, Romanian Journal of Clinical Research, V6, P21
   Perkins P, 2003, J PAIN SYMPTOM MANAG, V26, P785, DOI 10.1016/S0885-3924(03)00280-X
   PETERSSON J, 1995, BRIT J PHARMACOL, V115, P889, DOI 10.1111/j.1476-5381.1995.tb15893.x
   Petruzzi M, 2004, J ORAL PATHOL MED, V33, P111, DOI 10.1111/j.1600-0714.2004.0194n.x
   Pilcher JM, 1996, AMERICAS, V53, P193, DOI 10.2307/1007616
   Pintér E, 2006, PHARMACOL THERAPEUT, V112, P440, DOI 10.1016/j.pharmthera.2006.04.010
   Pramanik KC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020151
   PUIG L, 1995, DERMATOLOGY, V191, P73, DOI 10.1159/000246496
   Qin JC, 2021, WORLD J GASTROENTERO, V27, P6615, DOI 10.3748/wjg.v27.i39.6615
   Qin LL, 2019, J CHROMATOGR B, V1133, DOI 10.1016/j.jchromb.2019.121843
   Que TT, 2022, CHEM-BIOL INTERACT, V366, DOI 10.1016/j.cbi.2022.110043
   Quiroga-Garza ME, 2023, FRONT TOXICOL, V5, DOI 10.3389/ftox.2023.1118731
   Raisinghani M, 2005, J PHYSIOL-LONDON, V567, P771, DOI 10.1113/jphysiol.2005.087874
   Rajput H, 2024, INT J BIOL MACROMOL, V256, DOI 10.1016/j.ijbiomac.2023.128392
   Rakhshandehroo E., 2016, Veteriner Fakultesi Dergisi (Istanbul), V42, P132, DOI 10.16988/iuvfd.2016.91882
   Ramos-Torres A, 2016, ONCOTARGET, V7, P1569, DOI 10.18632/oncotarget.6415
   Raza K, 2014, J LIPOSOME RES, V24, P290, DOI 10.3109/08982104.2014.911314
   Raza K, 2011, J DRUG TARGET, V19, P293, DOI 10.3109/1061186X.2010.499464
   Redington KL, 2012, BASIC RES CARDIOL, V107, DOI 10.1007/s00395-011-0241-5
   Reeh PW, 2022, PFLUG ARCH EUR J PHY, V474, P405, DOI 10.1007/s00424-022-02667-x
   Reilly CA, 2002, J ANAL TOXICOL, V26, P313, DOI 10.1093/jat/26.6.313
   Reilly CA, 2006, DRUG METAB REV, V38, P685, DOI 10.1080/03602530600959557
   Ren XP, 2019, AM J PHYSIOL-HEART C, V316, pH543, DOI 10.1152/ajpheart.00094.2018
   Ribbers GM, 2001, ARCH PHYS MED REHAB, V82, P851, DOI 10.1053/apmr.2001.21911
   RITTER S, 1990, J COMP NEUROL, V296, P447, DOI 10.1002/cne.902960310
   Robbins WR, 1998, ANESTH ANALG, V86, P579, DOI 10.1097/00000539-199803000-00027
   Rodrigues Da Silva L., 2016, Natural Bioactive Compounds from Fruits and Vegetables as Health Promoters Part II
   Rollyson WD, 2014, J CONTROL RELEASE, V196, P96, DOI 10.1016/j.jconrel.2014.09.027
   Romero V, 2019, REV BRAS ANESTESIOL, V69, P432, DOI 10.1016/j.bjan.2019.06.008
   Romero-Cóndor CW, 2023, CIENCIA LATINA, V7, P2584, DOI [10.37811/cl_rcm.v7i4.7128, 10.37811/clrcm.v7i4.7128, DOI 10.37811/CLRCM.V7I4.7128]
   Rosenberger DC, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-019-02200-2
   Rothenberger J, 2019, CLIN HEMORHEOL MICRO, V71, P291, DOI 10.3233/CH-180373
   ROYS R.L., 1931, The Ethno-botany of the Maya
   Saguil A, 2017, AM FAM PHYSICIAN, V96, P656
   Saleh BK, 2018, MOJ Food Processing & Technology, V6, DOI [10.15406/mojfpt.2018.06.00183, 10.15406/mojfpt.2018.06.00183, DOI 10.15406/MOJFPT.2018.06.00183]
   Sandford P R, 2000, J Spinal Cord Med, V23, P238
   Sappington RM, 2009, INVEST OPHTH VIS SCI, V50, P717, DOI 10.1167/iovs.08-2321
   Sarwa KK, 2015, DRUG DELIV, V22, P1043, DOI 10.3109/10717544.2013.861041
   Sayanlar J, 2012, J HEADACHE PAIN, V13, P587, DOI 10.1007/s10194-012-0467-0
   Scarpignato C, 2001, CHEMOTHERAPY, V47, P1, DOI 10.1159/000049157
   Schäfer RC, 2022, J INVEST SURG, V35, P1673, DOI 10.1080/08941939.2022.2091694
   Scheau C, 2021, FARMACIA, V69, P778, DOI 10.31925/farmacia.2021.4.20
   Scheau C, 2021, CANCERS, V13, DOI 10.3390/cancers13092277
   Scheau C, 2020, FARMACIA, V68, P984, DOI 10.31925/farmacia.2020.6.4
   Scheau C, 2019, MOLECULES, V24, DOI 10.3390/molecules24132350
   Schmiedel U, 2016, CONSERV BIOL, V30, P506, DOI 10.1111/cobi.12661
   Segawa Y, 2020, CLIN EXP HYPERTENS, V42, P352, DOI 10.1080/10641963.2019.1665676
   Sell EA, 2021, ANN ALLERG ASTHMA IM, V126, P143, DOI 10.1016/j.anai.2020.10.011
   Sendel M, 2023, PAIN, V164, P534, DOI 10.1097/j.pain.0000000000002735
   Sharma SK, 2013, EUR J PHARMACOL, V720, P55, DOI 10.1016/j.ejphar.2013.10.053
   Shin MK, 2020, ANIM CELLS SYST, V24, P214, DOI 10.1080/19768354.2020.1810771
   Shuba YM, 2021, FRONT CELL NEUROSCI, V14, DOI 10.3389/fncel.2020.612480
   Silva-Clavería F, 2022, J DTSCH DERMATOL GES, V20, P1221, DOI 10.1111/ddg.14826
   Simone DA, 1998, J NEUROSCI, V18, P8947
   Simpson DM, 2008, J PAIN SYMPTOM MANAG, V35, P299, DOI 10.1016/j.jpainsymman.2007.04.015
   Skrzypski M, 2014, CELL SIGNAL, V26, P41, DOI 10.1016/j.cellsig.2013.09.014
   Smith MichaelE., 2013, The Aztecs
   Snyman T, 2001, FORENSIC SCI INT, V124, P43, DOI 10.1016/S0379-0738(01)00571-0
   Späth E, 1930, BER DTSCH CHEM GES, V63, P737, DOI 10.1002/cber.19300630331
   Srinivasan K, 2016, CRIT REV FOOD SCI, V56, P1488, DOI 10.1080/10408398.2013.772090
   Ständer S, 2001, J AM ACAD DERMATOL, V44, P471, DOI 10.1067/mjd.2001.110059
   Ständer S, 2004, EXP DERMATOL, V13, P129, DOI 10.1111/j.0906-6705.2004.0178.x
   Sterner RT, 2005, PEST MANAG SCI, V61, P1202, DOI 10.1002/ps.1118
   Stichtenoth DO, 2003, DRUGS, V63, P33, DOI 10.2165/00003495-200363010-00003
   Stock Birte, 2013, Animals (Basel), V4, P1, DOI 10.3390/ani4010001
   Sukmanadi Mohammad, 2021, Pharmacognosy Journal, V13, P1573, DOI [10.5530/pj.2021.13.201, 10.5530/pj.2021.13.201]
   Sung Y, 2005, BOT BULL ACAD SINICA, V46, P35
   Suresh D, 2010, INDIAN J MED RES, V131, P682
   SURH YJ, 1995, LIFE SCI, V56, P1845, DOI 10.1016/0024-3205(95)00159-4
   SZALLASI A, 1989, NEUROSCIENCE, V30, P515, DOI 10.1016/0306-4522(89)90269-8
   Szoka L, 2020, BIOMED PHARMACOTHER, V132, DOI 10.1016/j.biopha.2020.110741
   Szolcsányi J, 2004, NEUROPEPTIDES, V38, P377, DOI 10.1016/j.npep.2004.07.005
   Szolcsányi J, 2001, J PHYSIOL-PARIS, V95, P181, DOI 10.1016/S0928-4257(01)00023-7
   Szolcsányi J, 1998, BRIT J PHARMACOL, V123, P936, DOI 10.1038/sj.bjp.0701685
   Tabrizi MA, 2017, MED RES REV, V37, P936, DOI 10.1002/med.21427
   Tampa M, 2020, J CLIN MED, V9, DOI 10.3390/jcm9093010
   TANDAN R, 1992, DIABETES CARE, V15, P8, DOI 10.2337/diacare.15.1.8
   Tarng DC, 1996, NEPHRON, V72, P617, DOI 10.1159/000188949
   Tatsimo Simplice Joel Ndendoung, 2012, BMC Res Notes, V5, P158, DOI 10.1186/1756-0500-5-158
   Teixeira MJ, 2015, ARQ NEURO-PSIQUIAT, V73, P237, DOI 10.1590/0004-282X20140232
   Ternesten-Hasséus E, 2015, RESP MED, V109, P27, DOI 10.1016/j.rmed.2014.11.001
   Tewksbury JJ, 2006, J CHEM ECOL, V32, P547, DOI 10.1007/s10886-005-9017-4
   Thán M, 2000, EUR J PHARMACOL, V399, P251, DOI 10.1016/S0014-2999(00)00341-1
   Thomas KC, 2011, J PHARMACOL EXP THER, V337, P400, DOI 10.1124/jpet.110.178491
   Thompson J.Eric., 1990, Maya History and Religion
   Thresh J.C., 1877, Analyst, V2, P108, DOI [10.1039/AN8770200108, DOI 10.1039/AN8770200108]
   Thresh J.C., 1876, PHARM J T, V7, P259
   Thresh L.T., 1876, Pharm J Trans, V6, P941
   Tian K, 2019, PESTIC BIOCHEM PHYS, V156, P145, DOI 10.1016/j.pestbp.2019.02.015
   Tidwell R.D., 2023, StatPearls
   Timofticiuc IA, 2024, J FUNCT BIOMATER, V15, DOI 10.3390/jfb15010007
   Töle JC, 2019, HAND CLINIC, V164, P173, DOI 10.1016/B978-0-444-63855-7.00011-3
   Tominaga M, 1998, NEURON, V21, P531, DOI 10.1016/S0896-6273(00)80564-4
   Tominaga M, 2005, PFLUG ARCH EUR J PHY, V451, P143, DOI 10.1007/s00424-005-1457-8
   Trevisan G, 2013, EUR J PHARMACOL, V714, P332, DOI 10.1016/j.ejphar.2013.07.029
   Vachiramon V, 2023, SKIN RES TECHNOL, V29, DOI 10.1111/srt.13240
   van Eijl S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041721
   Van Gerven L, 2021, J ALLERGY CLIN IMMUN, V147, P397, DOI 10.1016/j.jaci.2020.04.054
   Varindra Pandhair, 2009, Indian Journal of Agricultural Biochemistry, V22, P78
   Vendrely V, 2017, CANCER LETT, V390, P91, DOI 10.1016/j.canlet.2017.01.002
   Venier NA, 2015, PROSTATE, V75, P113, DOI 10.1002/pros.22896
   Votava EJ, 2005, ECON BOT, V59, P8, DOI 10.1663/0013-0001(2005)059[0008:GDOCCA]2.0.CO;2
   Wachtel RE, 1999, REGION ANESTH PAIN M, V24, P361, DOI 10.1016/S1098-7339(99)90113-X
   Wang F, 2016, CANCER BIOL THER, V17, P1117, DOI 10.1080/15384047.2016.1235654
   Wang FZ, 2022, CRIT REV FOOD SCI, V62, P5322, DOI 10.1080/10408398.2021.1884840
   Wang LB, 2023, AGING-US, V15, P11845, DOI 10.18632/aging.205138
   Wang S, 2020, ENEURO, V7, DOI 10.1523/ENEURO.0118-20.2020
   Wang XR, 2017, INT J NANOMED, V12, P3881, DOI 10.2147/IJN.S131901
   Warburg O., 1925, J CAN RES, P148, DOI DOI 10.1158/JCR.1925.148
   WARBURG OTTO, 1926, KLIN WOCHENSCHR, V5, P829, DOI 10.1007/BF01726240
   WATSON CPN, 1993, CLIN THER, V15, P510
   WATSON CPN, 1992, PAIN, V51, P375, DOI 10.1016/0304-3959(92)90223-X
   WATTS SW, 1991, PEPTIDES, V12, P1057, DOI 10.1016/0196-9781(91)90060-3
   WECKBECKER G, 1993, PHARMACOL THERAPEUT, V60, P245, DOI 10.1016/0163-7258(93)90009-3
   WEINBERG RB, 1981, NEW ENGL J MED, V305, P1020
   Weisshaar E, 2003, NEUROSCI LETT, V345, P192, DOI 10.1016/S0304-3940(03)00511-1
   Weisshaar E, 1998, ARCH DERMATOL RES, V290, P306, DOI 10.1007/s004030050309
   Williams DE, 2017, ROUTL HANDBK, P192
   WILLIAMS SR, 1995, ANN EMERG MED, V25, P713, DOI 10.1016/S0196-0644(95)70188-5
   Wong GY, 2009, BRAIN RES REV, V60, P267, DOI 10.1016/j.brainresrev.2008.12.006
   Wu D, 2020, MOL MED REP, V22, P4868, DOI 10.3892/mmr.2020.11585
   Wu LY, 2022, PHYTOTHER RES, V36, P938, DOI 10.1002/ptr.7361
   Wu Y, 2008, GYNECOL OBSTET INVES, V66, P59, DOI 10.1159/000124275
   Wutka A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095605
   Xiang YW, 2022, EXP CELL RES, V417, DOI 10.1016/j.yexcr.2022.113227
   Xie DD, 2022, FRONT CHEM, V10, DOI 10.3389/fchem.2022.929050
   Xie M, 2023, RSC ADV, V13, P32150, DOI 10.1039/d3ra05107b
   Xie ZQ, 2022, CANCER MED-US, V11, P4283, DOI 10.1002/cam4.4777
   Xiong Z, 2022, IMMUNITY, V55, P686, DOI 10.1016/j.immuni.2022.03.001
   Xu MQ, 2022, BIOMATERIALS, V284, DOI 10.1016/j.biomaterials.2022.121520
   Xu SL, 2023, SCHIZOPHRENIA-UK, V9, DOI 10.1038/s41537-023-00406-4
   Xu Y, 2017, EXP LUNG RES, V43, P8, DOI 10.1080/01902148.2016.1271481
   Yaldiz G, 2010, IND CROP PROD, V32, P434, DOI 10.1016/j.indcrop.2010.06.013
   Yang F, 2017, PROTEIN CELL, V8, P169, DOI 10.1007/s13238-016-0353-7
   Yang N, 2021, LWT-FOOD SCI TECHNOL, V138, DOI 10.1016/j.lwt.2020.110613
   Yang N, 2020, FOOD RES INT, V133, DOI 10.1016/j.foodres.2020.109197
   Yang R, 2014, CELL MOL NEUROBIOL, V34, P565, DOI 10.1007/s10571-014-0041-1
   Yang SY, 2019, CHEM-BIOL INTERACT, V297, P1, DOI 10.1016/j.cbi.2018.10.006
   Yang TJ, 2022, ANN TRANSL MED, V10, DOI 10.21037/atm-21-6145
   Yenigun Onur M, 2019, Clin Pract Cases Emerg Med, V3, P219, DOI [10.5811/cpcem.2019.3.41231, 10.5811/cpcem.2019.3.41231]
   Yeung MF, 2015, HONG KONG MED J, V21, P542, DOI 10.12809/hkmj154691
   Yoshie K, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.124477
   Yosipovitch G, 2005, J DERMATOL TREAT, V16, P178, DOI 10.1080/09546630510041079
   Yu Q, 2012, MOL BIOL REP, V39, P7583, DOI 10.1007/s11033-012-1592-1
   Yu TY, 2019, J PHOTOCH PHOTOBIO B, V197, DOI 10.1016/j.jphotobiol.2019.111534
   Zak A, 2018, BMC VET RES, V14, DOI 10.1186/s12917-018-1518-9
   Zarghi A, 2011, IRAN J PHARM RES, V10, P655
   Zeidler C, 2016, J EUR ACAD DERMATOL, V30, P1236, DOI 10.1111/jdv.13165
   Zhang CY, 2020, CHANNELS, V14, P141, DOI 10.1080/19336950.2020.1747803
   Zhang Q, 2022, CELL CHEM BIOL, V29, P1248, DOI 10.1016/j.chembiol.2022.06.011
   Zhang R, 2008, APOPTOSIS, V13, P1465, DOI 10.1007/s10495-008-0278-6
   Zhang SP, 2020, J CLIN PHARM THER, V45, P16, DOI 10.1111/jcpt.13039
   Zhen X, 2018, NANO LETT, V18, P1498, DOI 10.1021/acs.nanolett.7b05292
   Zheng L, 2015, ONCOL REP, V34, P1027, DOI 10.3892/or.2015.4055
   Zhou MM, 2023, BIOMED PHARMACOTHER, V161, DOI 10.1016/j.biopha.2023.114516
   Zhou Y, 2001, NEUROPHARMACOLOGY, V41, P601, DOI 10.1016/S0028-3908(01)00106-X
   Zhu MM, 2020, PHYTOTHER RES, V34, P817, DOI 10.1002/ptr.6563
   Zis P, 2014, PAIN PHYSICIAN, V17, pE213
   Al-Rifai AA, 2012, MED CHEM RES, V21, P468, DOI 10.1007/s00044-011-9553-0
   Choo S, 2020, FOLIA MICROBIOL, V65, P451, DOI 10.1007/s12223-020-00786-5
   Dumitrache MD, 2021, EXP THER MED, V22, DOI 10.3892/etm.2021.10349
   Frieri M, 2017, J INFECT PUBLIC HEAL, V10, P369, DOI 10.1016/j.jiph.2016.08.007
   Gunes H, 2016, TOXICOL IND HEALTH, V32, P246, DOI 10.1177/0748233713498458
   Hirai I, 2010, INT J FOOD SCI TECH, V45, P1250, DOI 10.1111/j.1365-2621.2010.02267.x
   Jaisinghani RN, 2017, MICROBIOLOGY RES, V8, P13, DOI 10.4081/mr.2017.6877
   Jumaah O, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.38274
   Kang C, 2017, MBIO, V8, DOI [10.1128/mBio.00470-17, 10.1128/mBio.00900-17, 10.1128/mbio.00470-17]
   Li HY, 2008, J ALTERN COMPLEM MED, V14, P621, DOI 10.1089/acm.2007.0606
   Liao YL, 2018, COLLOID INTERFAC SCI, V25, P1, DOI 10.1016/j.colcom.2018.04.009
   Ma WT, 2003, J ALTERN COMPLEM MED, V9, P851, DOI 10.1089/107555303771952208
   MacGowan A, 2017, Medicine, V45, P622, DOI [10.1016/j.mpmed.2017.07.006, DOI 10.1016/j.mpmed.2017.07.006, 10.1016/j.mpmed.2017.07.006, DOI 10.1016/J.MPMED.2017.07.006]
   Massoth C, 2023, ANASTH INTENSIV NOTF, V58, P264, DOI 10.1055/a-1933-2408
   Miyakis S, 2011, CLIN INFECT DIS, V53, P177, DOI 10.1093/cid/cir323
   Nakamoto M, 2020, EXP THER MED, V19, P1550, DOI 10.3892/etm.2019.8388
   NEU HC, 1992, SCIENCE, V257, P1064, DOI 10.1126/science.257.5073.1064
   Ojala T, 2000, J ETHNOPHARMACOL, V73, P299, DOI 10.1016/S0378-8741(00)00279-8
   Periferakis A, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19084669
   Popa LI, 2021, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.610296
   Popescu GDA, 2021, MOLECULES, V26, DOI 10.3390/molecules26010094
   Rafila A, 2015, REV ROMANA MED LAB, V23, P295, DOI 10.1515/rrlm-2015-0024
   Rosca AE, 2020, MOLECULES, V25, DOI 10.3390/molecules25235681
   Shu Y, 2011, AFR J MICROBIOL RES, V5, P5358, DOI 10.5897/AJMR11.849
   Smyth T, 2009, INT J ANTIMICROB AG, V33, P421, DOI 10.1016/j.ijantimicag.2008.10.022
   Talapan D, 2022, INFECT DRUG RESIST, V15, P2959, DOI 10.2147/IDR.S360048
   Teow SY, 2015, PAK J PHARM SCI, V28, P2109
   Wallock-Richards D, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112726
   Weng GY, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.727951
   Yao W, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/853516
   Yun DG, 2016, APPL MICROBIOL BIOT, V100, P5505, DOI 10.1007/s00253-016-7415-x
   Zhang WB, 2013, CHIN J INTEGR MED, V19, P330, DOI 10.1007/s11655-013-1456-0
NR 532
TC 29
Z9 35
U1 14
U2 46
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD AUG
PY 2024
VL 46
IS 8
BP 7895
EP 7943
DI 10.3390/cimb46080468
PG 49
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA E8X0S
UT WOS:001305761900001
PM 39194685
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Calcagni, N
   Gana, K
   Quintard, B
AF Calcagni, Nicolas
   Gana, Kamel
   Quintard, Bruno
TI A systematic review of complementary and alternative medicine in
   oncology: Psychological and physical effects of manipulative and
   body-based practices
SO PLOS ONE
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; BREAST-CANCER;
   AROMATHERAPY MASSAGE; SUPPORTIVE CARE; DELIVERED REFLEXOLOGY;
   SYMPTOM-MANAGEMENT; CLINICAL-TRIAL; PAIN; ACUPRESSURE
AB Background
   Complementary and Alternative Medicines (CAM) are widely used by cancer patients, despite limited evidence of efficacy. Manipulative and body-based practices are some of the most commonly used CAM. This systematic review evaluates their benefits in oncology.
   Method
   A systematic literature review was carried out with no restriction of language, time, cancer location or type. PubMed, CENTRAL, PsycArticle, Psychlnfo, Psychology and Behavioral Sciences Collection and SOCindex were queried. Inclusion criteria were adult cancer patients and randomized controlled trials (RCT) assessing manipulative and body-based complementary practices on psychological and symptom outcomes. Effect size was calculated when applicable.
   Results
   Of 1624 articles retrieved, 41 articles were included: massage (24), reflexology (11), acu-pressure (6). Overall, 25 studies showed positive and significant effects on symptom outcomes (versus 9 that did not), especially pain and fatigue. Mixed outcomes were found for quality of life (8 papers finding a significant effect vs. 10 which did not) and mood (14 papers vs. 13). In most studies, there was a high risk of bias with a mean Jadad score of 2, making interpretation of results difficult.
   Conclusion
   These results seem to indicate that manipulative CAM may be effective on symptom management in cancer. However, more robust methodologies are needed. The methodological requirements of randomized controlled trials are challenging, and more informative results may be provided by more pragmatic study design.
C1 [Calcagni, Nicolas; Quintard, Bruno] INSERM, UMR 1219, Team Handicap Act Cognit Hlth HACH, Lab EA 4136, Bordeaux, France.
   [Calcagni, Nicolas; Gana, Kamel; Quintard, Bruno] Univ Bordeaux, Bordeaux, France.
C3 Universite de Bordeaux; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite de Bordeaux
RP Calcagni, N (corresponding author), INSERM, UMR 1219, Team Handicap Act Cognit Hlth HACH, Lab EA 4136, Bordeaux, France.; Calcagni, N (corresponding author), Univ Bordeaux, Bordeaux, France.
EM nicolas.calcagni@u-bordeaux.fr
OI Calcagni, Nicolas/0000-0003-3235-7066
FU French 'Site de Recherche Integree sur le Cancer Bordeaux Recherche
   Integree en Oncologie' (SIRIC -BRIO)
FX This research was funded by the French `Site de Recherche Integree sur
   le Cancer Bordeaux Recherche Integree en Oncologie' (SIRIC -BRIO,
   https://siric-brio.com), which brings together multidisciplinary
   research teams working in synergy to produce new knowledge for the
   benefit of patients. NC received the funding. This research was funded
   by the French `Site de Recherche Integree sur le Cancer-Bordeaux
   Recherche Integree en Oncologie' (SIRIC-BRIO), which brings together
   multidisciplinary research teams working in synergy to produce new
   knowledge for the benefit of patients.
CR [Anonymous], PLACE THERAPIES COMP
   [Anonymous], SYSTEMATIC REV, DOI DOI 10.1186/2046-4053-4-1
   [Anonymous], INT J NURSING PRACTI
   [Anonymous], PSYCEXTRA DATASET
   [Anonymous], CLIN CHIROPR
   [Anonymous], EFF SIZ CALC
   [Anonymous], INT ENCY SOCIAL BEHA
   [Anonymous], CURRENT ONCOLOGY
   [Anonymous], CANCER
   [Anonymous], 2018, COMPL ALT INT HLTH W
   [Anonymous], DEV PRESCR THER NONM
   [Anonymous], J CLIN EPIDEMIOLOGY
   Avci HS, 2016, HOLIST NURS PRACT, V30, P257, DOI 10.1097/HNP.0000000000000161
   Ayik C, 2018, COMPLEMENT THER MED, V36, P93, DOI 10.1016/j.ctim.2017.12.002
   Beikmoradi A, 2015, IRAN RED CRESCENT ME, V17, DOI 10.5812/ircmj.25919
   Berger VW, 2006, J RHEUMATOL, V33, P1710
   Billhult A, 2008, AUTON NEUROSCI-BASIC, V140, P88, DOI 10.1016/j.autneu.2008.03.006
   Billhult A, 2007, J ALTERN COMPLEM MED, V13, P53, DOI 10.1089/acm.2006.6049
   Bishop FL, 2010, PEDIATRICS, V125, P768, DOI 10.1542/peds.2009-1775
   Buchanan DR, 2005, J CLIN ONCOL, V23, P6682, DOI 10.1200/JCO.2005.10.728
   Buzyn A, 2014, EditionsPresses de Sciences Po Publications, V43, P53
   Campeau Marie-Pierre, 2007, J Soc Integr Oncol, V5, P133, DOI 10.2310/7200.2007.018
   Clark HD, 1999, CONTROL CLIN TRIALS, V20, P448, DOI 10.1016/S0197-2456(99)00026-4
   Cumming G., 2017, INTRO NEW STAT ESTIM, DOI DOI 10.4324/9781315708607
   Darabpour S, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.25461
   Donoyama N, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196638
   Ernst E, 2011, MATURITAS, V68, P116, DOI 10.1016/j.maturitas.2010.10.011
   Ernst E, 2009, SUPPORT CARE CANCER, V17, P333, DOI 10.1007/s00520-008-0569-z
   Fernández-Lao C, 2012, EUR J CANCER CARE, V21, P233, DOI 10.1111/j.1365-2354.2011.01306.x
   Giordano J, 2002, J ALTERN COMPLEM MED, V8, P897, DOI 10.1089/10755530260511892
   Harrison S, 2017, RES SYNTH METHODS, V8, P281, DOI 10.1002/jrsm.1239
   Hernandez-Reif M, 2004, J PSYCHOSOM RES, V57, P45, DOI 10.1016/S0022-3999(03)00500-2
   2011, BMJ-BRIT MED J, V343, pd5928, DOI [DOI 10.1136/BMJ.D5928, 10.1136/bmj.d5928]
   Hodgson H, 2000, Nurs Stand, V14, P33
   Hsiung WT, 2015, COMPLEMENT THER MED, V23, P339, DOI 10.1016/j.ctim.2015.03.010
   Jackson C, 2015, HOLIST NURS PRACT, V29, P178, DOI 10.1097/HNP.0000000000000088
   Jadad AR, 1996, CONTROL CLIN TRIALS, V17, P1, DOI 10.1016/0197-2456(95)00134-4
   Jane SW, 2011, PAIN, V152, P2432, DOI 10.1016/j.pain.2011.06.021
   Johnson SB, 2018, JAMA ONCOL, V4, P1375, DOI 10.1001/jamaoncol.2018.2487
   Kashani Fahimeh, 2014, Iran J Nurs Midwifery Res, V19, P113
   Kim JI, 2010, INTEGR CANCER THER, V9, P326, DOI 10.1177/1534735410387423
   Kotronoulas G, 2017, EUR J ONCOL NURS, V29, P60, DOI 10.1016/j.ejon.2017.05.004
   Krohn M, 2011, SUPPORT CARE CANCER, V19, P1303, DOI 10.1007/s00520-010-0946-2
   Kurt S, 2018, EUR J ONCOL NURS, V32, P12, DOI 10.1016/j.ejon.2017.11.001
   Kutner JS, 2008, ANN INTERN MED, V149, P369, DOI 10.7326/0003-4819-149-6-200809160-00003
   Lai T K T, 2011, Complement Ther Clin Pract, V17, P37, DOI 10.1016/j.ctcp.2010.02.004
   Ling WM, 2014, ONCOL NURS FORUM, V41, P581, DOI 10.1188/14.ONF.581-592
   Listing M, 2010, ARCH WOMEN MENT HLTH, V13, P165, DOI 10.1007/s00737-009-0143-9
   Listing M, 2009, PSYCHO-ONCOLOGY, V18, P1290, DOI 10.1002/pon.1508
   Loquai C, 2017, EUR J CANCER, V71, P70, DOI 10.1016/j.ejca.2016.10.029
   Massingill Jeanne, 2018, Int J Ther Massage Bodywork, V11, P4
   McVicar A, 2016, J ALTERN COMPLEM MED, V22, P739, DOI 10.1089/acm.2016.0015
   Miladinia M, 2017, CANCER NURS, V40, P31, DOI 10.1097/NCC.0000000000000353
   Molassiotis A, 2005, ANN ONCOL, V16, P655, DOI 10.1093/annonc/mdi110
   Özdelikara A, 2017, COMPLEMENT THER CLIN, V29, P122, DOI 10.1016/j.ctcp.2017.09.004
   Pan YQ, 2014, INT J CLIN ONCOL, V19, P829, DOI 10.1007/s10147-013-0635-5
   Price David, 2014, Ann Am Thorac Soc, V11 Suppl 2, pS92, DOI 10.1513/AnnalsATS.201308-276RM
   Richardson MA, 2000, J CLIN ONCOL, V18, P2505, DOI 10.1200/JCO.2000.18.13.2505
   Rizi MS, 2017, COMPLEMENT THER CLIN, V29, P136, DOI 10.1016/j.ctcp.2017.09.002
   Robinson N, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-88
   Ross CSK, 2002, PALLIATIVE MED, V16, P544, DOI 10.1191/0269216302pm597xx
   Scott E, 2019, Cancer Nursing Practice, V18, P35, DOI [10.7748/cnp.2019.e1566, 10.7748/cnp.2019.e1566, DOI 10.7748/CNP.2019.E1566]
   Sharp DM, 2010, EUR J CANCER, V46, P312, DOI 10.1016/j.ejca.2009.10.006
   Sikorskii A, 2009, NURS RES, V58, P444, DOI 10.1097/NNR.0b013e3181bf15fe
   Simon L, 2007, B CANCER, V94, P483
   Smith JD, 2012, PSYCHOL METHODS, V17, P510, DOI 10.1037/a0029312
   Soden K, 2004, PALLIATIVE MED, V18, P87, DOI 10.1191/0269216304pm874oa
   Stephenson N, 2003, APPL NURS RES, V16, P284, DOI 10.1016/j.apnr.2003.08.003
   Stephenson NLN, 2007, ONCOL NURS FORUM, V34, P127, DOI 10.1188/07.ONF.127-132
   Sterne J AC., BMJ
   Toth M, 2013, J ALTERN COMPLEM MED, V19, P650, DOI 10.1089/acm.2012.0466
   Tsay SL, 2008, CANCER NURS, V31, P109, DOI 10.1097/01.NCC.0000305694.74754.7b
   Uysal N, 2017, INT J NURS PRACT, V23, DOI 10.1111/ijn.12532
   Wang T, 2018, BMC PALLIAT CARE, V17, DOI 10.1186/s12904-018-0346-9
   Weinrich S P, 1990, Appl Nurs Res, V3, P140, DOI 10.1016/S0897-1897(05)80135-1
   Wilcock A, 2004, PALLIATIVE MED, V18, P287, DOI 10.1191/0269216304pm895oa
   Wilkie D J, 2000, Hosp J, V15, P31
   Wilkinson S, 2008, J ADV NURS, V63, P430, DOI 10.1111/j.1365-2648.2008.04712.x
   Wilkinson SM, 2007, J CLIN ONCOL, V25, P532, DOI 10.1200/JCO.2006.08.9987
   Wyatt G, 2017, J PAIN SYMPTOM MANAG, V54, P670, DOI 10.1016/j.jpainsymman.2017.07.037
   Wyatt G, 2012, ONCOL NURS FORUM, V39, P568, DOI 10.1188/12.ONF.568-577
   Zhang B, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000007750
NR 82
TC 28
Z9 34
U1 2
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 17
PY 2019
VL 14
IS 10
AR e0223564
DI 10.1371/journal.pone.0223564
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA LM9KP
UT WOS:000532567300028
PM 31622362
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Mazur-Bialy, A
   Tim, S
   Pepek, A
   Skotniczna, K
   Naprawa, G
AF Mazur-Bialy, Agnieszka
   Tim, Sabina
   Pepek, Anna
   Skotniczna, Kamila
   Naprawa, Gabriela
TI Holistic Approaches in Endometriosis - as an Effective Method of
   Supporting Traditional Treatment: A Systematic Search and Narrative
   Review
SO REPRODUCTIVE SCIENCES
LA English
DT Review
DE Endometriosis; Physiotherapy; Physical activity; Manual therapy; Quality
   of life; Pain
ID QUALITY-OF-LIFE; CHRONIC PELVIC PAIN; PSYCHOLOGICAL INTERVENTION;
   PHYSICAL-THERAPY; WOMEN; SENSITIZATION; EPIDEMIOLOGY; DYSPAREUNIA; YOGA
AB Endometriosis is one of the gynecological diseases where women suffer from pain, quality of life decreased. The aim of this review was to describe the most common non-medical methods used in the treatment of symptoms associated with endometriosis and to determine their effectiveness. The review was performed in PubMed, Embase and Web of Science databases. Randomized controlled trials, case studies, observational studies, retrospective studies, prospective studies, pilot studies, trails, publications in English or Polish were searched based on the Participant-Intervention-Comparator-Outcomes-Study design (PICOS) format. The criteria used to select studies were: women with endometriosis, no cancer, included any physiotherapeutic or non-medical intervention. 3706 articles were found, however only 26 met the inclusion criteria and were included in the review. Quality of the studies was assessed by Risk of Bias 2 tool and ROBINS-1 tool. The most holistic approach used in the treatment of symptoms of endometriosis include physical therapy, manual therapy, electrophysical agents acupuncture, diet and psychological interventions. Most research has focused on relieving pain and increasing quality of life. Non-medical methods showed reduction of symptoms of endometriosis. Physical activity, manual therapy, electrophysical agents, acupuncture, diet and cognitive behavioral therapy showed no negative side effects and reduced pain, what improved the quality of life and reduced the perceived stress.
C1 [Mazur-Bialy, Agnieszka; Tim, Sabina] Jagiellonian Univ, Fac Hlth Sci, Dept Biomech & Kinesiol, Med Coll, Skawinska 8, PL-31066 Krakow, Poland.
   [Pepek, Anna; Skotniczna, Kamila; Naprawa, Gabriela] Jagiellonian Univ, Fac Hlth Sci, Med Coll, Student Sci Grp, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Mazur-Bialy, A (corresponding author), Jagiellonian Univ, Fac Hlth Sci, Dept Biomech & Kinesiol, Med Coll, Skawinska 8, PL-31066 Krakow, Poland.
EM agnieszka.mazur@uj.edu.pl
RI Mazur-Bialy, Agnieszka/I-4882-2012; Tim, Sabina/ABP-3179-2022
OI Mazur-Bialy, Agnieszka/0000-0003-1056-8276; Tim,
   Sabina/0000-0001-5368-8812
CR Agarwal SK, 2019, AM J OBSTET GYNECOL, V220, DOI 10.1016/j.ajog.2018.12.039
   Alimi Yusuf, 2018, Cureus, V10, pe3361, DOI [10.7759/cureus.3361, 10.7759/cureus.3361]
   Aredo JV, 2017, SEMIN REPROD MED, V35, P88, DOI 10.1055/s-0036-1597123
   Armour M, 2019, BMC COMPLEM ALTERN M, V19, DOI 10.1186/s12906-019-2431-x
   Awad Eman, 2017, J Phys Ther Sci, V29, P2112, DOI [10.1589/jpts.29.2112, 10.1589/jpts.29.2112]
   Becker CM, 2022, HUM REPROD OPEN, V2022, DOI 10.1093/hropen/hoac009
   Bergström I, 2005, ACTA OBSTET GYN SCAN, V84, P380, DOI 10.1111/j.0001-6349.2005.00558.x
   Bi XL, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011266
   Brown J, 2015, JAMA-J AM MED ASSOC, V313, P296, DOI 10.1001/jama.2014.17119
   Cameron B, 2019, NEUROUROL URODYNAM, V38, P696, DOI 10.1002/nau.23896
   Caporossi L, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18020532
   Cirillo M, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241914601
   Daraï C, 2015, EUR J OBSTET GYN R B, V188, P70, DOI 10.1016/j.ejogrb.2015.03.001
   de Sousa TR, 2016, COMPLEMENT THER CLIN, V25, P114, DOI 10.1016/j.ctcp.2016.09.006
   Del Forno S, 2024, MEDICINA-LITHUANIA, V60, DOI 10.3390/medicina60010067
   Del Forno S, 2020, J SEX MARITAL THER, V46, P603, DOI 10.1080/0092623X.2020.1765057
   Donatti L, 2025, J HEALTH PSYCHOL, V30, P1004, DOI 10.1177/13591053241240198
   Falcone T, 2018, OBSTET GYNECOL, V131, P557, DOI 10.1097/AOG.0000000000002469
   Fernández-de-las-Peñas C, 2018, PAIN MED, V19, P142, DOI 10.1093/pm/pnx207
   Geri T, 2019, MUSCULOSKEL SCI PRAC, V44, DOI 10.1016/j.msksp.2019.07.008
   Gonçalves AV, 2017, J ALTERN COMPLEM MED, V23, P45, DOI 10.1089/acm.2015.0343
   Gonçalves AV, 2016, J ALTERN COMPLEM MED, V22, P977, DOI 10.1089/acm.2016.0021
   Hawkins RS, 2003, APPL PSYCHOPHYS BIOF, V28, P279, DOI 10.1023/A:1027378825194
   Kold M, 2012, NORD PSYCHOL, V64, P2, DOI 10.1080/19012276.2012.693727
   Krlak A., 2018, FARM POL, V74, P337, DOI [10.32383/farmpol/118772, DOI 10.32383/FARMPOL/118772]
   Lara-Ramos A, 2021, PAIN MED, V22, P1970, DOI 10.1093/pm/pnaa463
   Liberati Alessandro, 2009, PLoS Med, V6, pe1000100, DOI 10.1371/journal.pmed.1000100
   Lorbergs AL, 2019, J GERONTOL A-BIOL, V74, P420, DOI 10.1093/gerona/gly056
   McNamara HC, 2021, FRONT REPROD HEALTH, V3, DOI 10.3389/frph.2021.729642
   Mechsner S, 2022, J CLIN MED, V11, DOI 10.3390/jcm11020467
   Merlot B, 2022, J MED INTERNET RES, V24, DOI 10.2196/39531
   Minko A, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18158177
   Mira TAA, 2020, EUR J OBSTET GYN R B, V255, P134, DOI 10.1016/j.ejogrb.2020.10.018
   Morotti M, 2017, EUR J OBSTET GYN R B, V209, P8, DOI 10.1016/j.ejogrb.2016.07.497
   Morotti M, 2014, HUM REPROD UPDATE, V20, P717, DOI 10.1093/humupd/dmu021
   Muñoz-Gómez E, 2023, J CLIN MED, V12, DOI 10.3390/jcm12093310
   Nodler JL, 2020, AM J CLIN NUTR, V112, P229, DOI 10.1093/ajcn/nqaa096
   Orr NL, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.0780
   Orr NL, 2022, PAIN, V163, pE234, DOI 10.1097/j.pain.0000000000002351
   Parasar P, 2017, CURR OBSTET GYNECOL, V6, P34, DOI 10.1007/s13669-017-0187-1
   Parazzini F, 2017, EUR J OBSTET GYN R B, V209, P3, DOI 10.1016/j.ejogrb.2016.04.021
   Piggin J, 2020, FRONT SPORTS ACT LIV, V2, DOI 10.3389/fspor.2020.00072
   Quintner JL, 2015, RHEUMATOLOGY, V54, P392, DOI 10.1093/rheumatology/keu471
   Rubi-Klein K, 2010, EUR J OBSTET GYN R B, V153, P90, DOI 10.1016/j.ejogrb.2010.06.023
   Samy A, 2021, J GYNECOL OBSTET HUM, V50, DOI 10.1016/j.jogoh.2020.101798
   dos Bispo APS, 2016, ARCH GYNECOL OBSTET, V294, P519, DOI 10.1007/s00404-016-4025-x
   Petrelluzzi KFS, 2012, J PSYCHOSOM OBST GYN, V33, P191, DOI 10.3109/0167482X.2012.729625
   Sillem M, 2016, GEBURTSH FRAUENHEILK, V76, P960, DOI 10.1055/s-0042-111010
   Smolarz B, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221910554
   Sterne J., 2019, BMJ, V366, P14898, DOI [10.1136/bmj.l4898, DOI 10.1136/BMJ.L4898]
   Sterne JAC, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i4919
   Tennfjord MK, 2021, BMC WOMENS HEALTH, V21, DOI 10.1186/s12905-021-01500-4
   Thabet AA, 2018, PHOTOMED LASER SURG, V36, P363, DOI 10.1089/pho.2017.4419
   Tian LY, 2022, WORLD J ACUPUNCT-MOX, V32, P199, DOI 10.1016/j.wjam.2021.11.004
   van Haaps AP, 2023, HUM REPROD, V38, P2433, DOI 10.1093/humrep/dead214
   Warzecha D, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17103641
   Wojcik M, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192316148
   Wojcik M, 2022, GINEKOL POL, V93, P511, DOI 10.5603/GP.a2022.0021
   Wu SS, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000032433
   Wurn BF, 2011, J ENDOMETR PELVIC PA, V3, P188, DOI 10.5301/JE.2012.9088
   Zhao LP, 2012, EUR J OBSTET GYN R B, V162, P211, DOI 10.1016/j.ejogrb.2012.02.029
   Zheng P, 2019, J PAIN RES, V12, P1447, DOI 10.2147/JPR.S197667
   Zondervan KT, 2018, NAT REV DIS PRIMERS, V4, DOI 10.1038/s41572-018-0008-5
NR 63
TC 2
Z9 2
U1 3
U2 12
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1933-7191
EI 1933-7205
J9 REPROD SCI
JI Reprod. Sci.
PD NOV
PY 2024
VL 31
IS 11
BP 3257
EP 3274
DI 10.1007/s43032-024-01660-2
EA JUL 2024
PG 18
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA K8R3D
UT WOS:001275211300001
PM 39043999
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Ho, EY
   Agne, RR
   Santana, T
   Thompson, N
   McClendon, G
   Ng, E
   Merrick, S
   Gonzalez, F
   Smith, T
   Drewke, K
   Gutierrez, A
   Floyd, G
   Chao, MT
AF Ho, Evelyn Y.
   Agne, Robert R.
   Santana, Trilce
   Thompson, Nicole
   McClendon, Genevieve
   Ng, Eliza
   Merrick, Shannette
   Gonzalez, Felicia
   Smith, Tenaya
   Drewke, Kathleen
   Gutierrez, Amalia
   Floyd, Gary
   Chao, Maria T.
TI A Communication Perspective on What Patient Advisory Boards Do:
   Action-Implicative Discourse Analysis and Negotiating Advice
SO JOURNAL OF GENERAL INTERNAL MEDICINE
LA English
DT Article
DE acupuncture; pragmatic effectiveness; pain; cancer; implementation;
   inpatient
ID STAKEHOLDER ENGAGEMENT; TALK; STRATEGIES
AB Stakeholder advisory boards are recognized as an essential and useful part of patient-centered research. However, such engagement can involve exchanges of diverse individual experiences, multiple opinions, and strong feelings in the face of researchers' limitations, deadlines, and agendas. Yet, little work examines how these potential tensions occur and are resolved in actual advisory board meetings. This perspective article describes and employs a communication framework for analyzing a patient advisory council (PAC) for a comparative effectiveness study on acupuncture and pain counseling for inpatients with cancer. The framework, Action-Implicative Discourse Analysis (AIDA), is an observational method that examines challenges through recorded and transcribed, naturally occurring interaction. Our analysis focused on two short excerpts from the first PAC meeting to demonstrate members' navigation of advice-giving and advice-receiving-one in which advice was ultimately implemented by the study team and another in which it was deemed unfeasible. Although advice is inherent to the work of all PACs, it often emerges unannounced as negotiated moments, made up of seemingly minor conversation moves. As a recurring event, advice can and should be analyzed and discussed within PACs to improve communication and team dynamics.
C1 [Ho, Evelyn Y.] Univ San Francisco, Dept Commun Studies, 2130 Fulton St,Commun Studies KA 313, San Francisco, CA 94117 USA.
   [Ho, Evelyn Y.; Chao, Maria T.] Univ Calif San Francisco, Asian Amer Res Ctr Hlth, San Francisco, CA 94143 USA.
   [Ho, Evelyn Y.; McClendon, Genevieve; Ng, Eliza; Merrick, Shannette; Gonzalez, Felicia; Smith, Tenaya; Drewke, Kathleen; Gutierrez, Amalia; Floyd, Gary] Pragmat Res Acupuncture & Counseling eXtended Inp, San Francisco, CA USA.
   [Agne, Robert R.] Auburn Univ, Sch Commun & Journalism, Auburn, AL 36849 USA.
   [Santana, Trilce; Thompson, Nicole; Chao, Maria T.] UCSF, Osher Ctr Integrat Med, San Francisco, CA USA.
   [Merrick, Shannette] Univ Calif Davis, Sch Med, Davis, CA USA.
   [Chao, Maria T.] UCSF, Dept Med, Div Gen Internal Med, San Francisco Gen Hosp, San Francisco, CA USA.
C3 University of San Francisco; University of California System; University
   of California San Francisco; Auburn University System; Auburn
   University; University of California System; University of California
   San Francisco; University of California System; University of California
   Davis; University of California System; University of California San
   Francisco
RP Ho, EY (corresponding author), Univ San Francisco, Dept Commun Studies, 2130 Fulton St,Commun Studies KA 313, San Francisco, CA 94117 USA.
EM eyho@usfca.edu
RI Ho, Evelyn Y/AAE-6177-2020
OI Ho, Evelyn Y/0000-0001-8629-0122
FU Patient-Centered Outcomes Research Institute (PCORI) Award
   [CER-1609-36220]; Helen Diller Family Foundation; UCSF/Genentech
   MidCareer Award
FX Research reported in this publication was partially funded through a
   Patient-Centered Outcomes Research Institute (PCORI) Award
   (CER-1609-36220). Additional support was provided by the Helen Diller
   Family Foundation and a UCSF/Genentech MidCareer Award (MTC). All
   statements in this report, including its findings and conclusions, are
   solely those of the authors and do not necessarily represent the views
   of the PCORI, its Board of Governors or Methodology Committee.
CR Agne RR, 2007, DISCOURSE SOC, V18, P549, DOI 10.1177/0957926507079634
   Agne RR, 2019, COMMUN EDUC, V68, P265, DOI 10.1080/03634523.2019.1606433
   Agne RR, 2010, SOUTH COMMUN J, V75, P306, DOI 10.1080/1041794x.2010.504438
   Anderson A, 2019, CLIN THER, V41, P1408, DOI 10.1016/j.clinthera.2019.06.006
   Castor T, 2016, MANAGE COMMUN Q, V30, P472, DOI 10.1177/0893318916646454
   Concannon TW, 2014, J GEN INTERN MED, V29, P1692, DOI 10.1007/s11606-014-2878-x
   Craig R.T., 2020, Grounded Practical Theory: Investigating Communication Problems, DOI DOI 10.1002/9781118611463.WBIELSI146
   Craig R.T., 2006, Communication as ...: Perspectives on theory, P38, DOI [10.4135/9781483329055.n5, DOI 10.4135/9781483329055.N5, DOI 10.4135/9781483329055]
   Craig RT, 2018, J COMMUN, V68, P289, DOI 10.1093/joc/jqx013
   Craig RT, 2005, CONTROVERSIES, V2, P11
   Denvir P, 2014, COMMUNITY MED, V11, P263, DOI [10.1558/cam.v11i3.17876, DOI 10.1558/CAM.V11I3.17876]
   Dimock A, 2010, ARGUMENTATION, V24, P423, DOI 10.1007/s10503-009-9175-6
   Esmail Laura, 2015, J Comp Eff Res, V4, P133, DOI [10.2217/cer.14.79, 10.2217/cer.14.79]
   Fitch KristineL., 2005, Handbook of Language and Social Interaction
   Forsythe LP, 2016, J GEN INTERN MED, V31, P13, DOI 10.1007/s11606-015-3450-z
   Frank L, 2015, QUAL LIFE RES, V24, P1033, DOI 10.1007/s11136-014-0893-3
   Goldsmith DJ, 1997, HUM COMMUN RES, V23, P454, DOI 10.1111/j.1468-2958.1997.tb00406.x
   Mirivel JC, 2005, RES LANG SOC INTERAC, V38, P1, DOI 10.1207/s15327973rlsi3801_1
   Mirivel JC, 2007, DISCOURSE COMMUN, V1, P309, DOI 10.1177/1750481307079203
   Mirivel JC, 2008, HEALTH COMMUN, V23, P153, DOI 10.1080/10410230801968203
   Muller HL, 2014, J APPL COMMUN RES, V42, P325, DOI 10.1080/00909882.2014.911941
   Oldfield BJ, 2019, J GEN INTERN MED, V34, P1292, DOI 10.1007/s11606-018-4565-9
   Robles JS, 2012, DISCOURSE STUD, V14, P753, DOI 10.1177/1461445612457490
   Sharma AE, 2016, J AM BOARD FAM MED, V29, P775, DOI 10.3122/jabfm.2016.06.150380
   Sheridan S, 2017, ANN FAM MED, V15, P165, DOI 10.1370/afm.2042
   Sprain L, 2017, COMMUN MONOGR, V84, P241, DOI 10.1080/03637751.2016.1257141
   Tracy K, 2010, RHETOR DEMOCR DELIB, P1
   Tracy K, 2005, LEA COMMUN SER, P301
   TRACY K, 1995, J LANG SOC PSYCHOL, V14, P195, DOI 10.1177/0261927X95141011
   Tracy K., 1999, Discourse Studies, V1, P201, DOI [DOI 10.1177/1461445699001002004, 10.1177/1461445699001002004]
   Tracy K, 2010, PRAG BEYOND NEW SER, V196, P145
NR 31
TC 1
Z9 1
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0884-8734
EI 1525-1497
J9 J GEN INTERN MED
JI J. Gen. Intern. Med.
PD APR
PY 2022
VL 37
IS SUPPL 1
SU 1
SI SI
BP 99
EP 104
DI 10.1007/s11606-021-07062-3
EA SEP 2021
PG 6
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA 0L3EW
UT WOS:000702178800002
PM 34591265
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Stringer, J
   Ryder, WD
   Mackereth, PA
   Misra, V
   Wardley, AM
AF Stringer, Jacqui
   Ryder, W. David
   Mackereth, Peter A.
   Misra, Vivek
   Wardley, Andrew M.
TI A randomised, pragmatic clinical trial of ACUpuncture plus standard care
   versus standard care alone FOr Chemotherapy Induced peripheral
   Neuropathy (ACUFOCIN)
SO EUROPEAN JOURNAL OF ONCOLOGY NURSING
LA English
DT Article
DE Acupuncture; Chemotherapy induced peripheral neuropathy; Controlled
   trial
ID SYMPTOMS
AB Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose limiting toxicity posing a major clinical challenge for managing patients receiving specific chemotherapy regimens (e.g., Taxanes). There is a growing body of literature suggesting acupuncture can improve CIPN symptoms. The purpose of the ACUFOCIN trial was to collect preliminary data on the safety, feasibility, acceptability and initial effectiveness of acupuncture as a treatment for CIPN, comparing use of acupuncture plus standard care (Acupuncture) against standard care alone (Control). Method: At a tertiary cancer centre, a pragmatic, randomised, parallel group design study was used to investigate the effectiveness of a 10-week course of acupuncture. Participants experiencing CIPN of >= Grade II, recording a "Most Troublesome' CIPN symptom score of >= 3 using the "Measure Yourself Medical Outcome Profile " (MYMOP 2), were randomised to "Acupuncture' or "Control' arms. Clinicians were blinded to allocated groups, however as it was not possible to blind participants, it cannot be guaranteed they did not disclose study allocation within their clinic assessments. The primary outcome measure was the number of patients reporting a >= 2-point improvement (success) in their MYMOP2 score at week 10. 100 participants (120 to allow for attrition) were required for a hypothesised improvement in success proportions from 30% to 55% using a primary analysis model with logistic regression adjusted for stratification factors and baseline MYMOP2 scores. Feasibility and acceptability of study design was addressed through percentage return of primary outcome, retention rate and a nested qualitative study. Results: Primary MYMOP2 outcome data at week 10 was available for 108/120 randomised participants; this is greater than the 100 participants required to adequately power the study. There were 36/53 (68%) successes in "Acupuncture' compared to 18/55 (33%) in "Control'. Beneficial effects were seen in the secondary outcome data, including clinicians' grading of neuropathy, EORTC, QLQ-CIPN20, QLQ-C30 summary scores and patient reported pain scores. There were no serious adverse events reported within the study and only 16 acupuncture associated events, none of which required intervention. Conclusion: A 10-week course of acupuncture resulted in measurable improvement in participants symptoms of CIPN. The results warrant further investigation.
C1 [Stringer, Jacqui; Mackereth, Peter A.; Misra, Vivek] Christie NHS Fdn Trust, Wilmslow Rd, Manchester M20 4BX, Lancs, England.
   [Stringer, Jacqui; Wardley, Andrew M.] Univ Manchester, Fac Biol Med & Hlth, Sch Med Sci, Oxford Rd, Manchester M13 9PL, Lancs, England.
   [Ryder, W. David] Univ Manchester, Fac Biol Med & Hlth, Manchester Clin Trials Unit, Oxford Rd, Manchester M13 9PL, Lancs, England.
   [Wardley, Andrew M.] Outreach Res & Innovat Grp, Adamson House,Ground Floor,Towers Business Pk, Didsbury M20 2YY, England.
C3 Christie NHS Foundation Trust; University of Manchester; University of
   Manchester
RP Stringer, J (corresponding author), Christie NHS Fdn Trust, Wilmslow Rd, Manchester M20 4BX, Lancs, England.
EM jacqui.stringer3@nhs.net; david.ryder@manchester.ac.uk;
   petermackereth@icloud.com; vivek.misra@nhs.net;
   Andrew.Wardley@Outreach-Research-Innovation.com
RI Wardley, Anew/GLU-5636-2022
OI Wardley, Anew/0000-0002-9639-0888; Stringer, Jacqui/0000-0001-9804-2038
FU National Institute for Health Research (NIHR) [PB-PG-0213-30129]; Pink
   Ribbon Foundation; National Institutes of Health Research (NIHR)
   [PB-PG-0213-30129] Funding Source: National Institutes of Health
   Research (NIHR)
FX This paper presents independent research funded by the National
   Institute for Health Research (NIHR) under its Research for Patient
   Benefit (RfPB) Programme (Grant Reference Number PB-PG-0213-30129). The
   views expressed are those of the authors and not necessarily those of
   the NIHR or the Department of Health and Social Care. The Pink Ribbon
   Foundation, Charity Number: 1080839, supported the financing of the
   Acupuncturists. The Funding bodies played no role in the design of the
   clinical trial, collection, analysis and interpretation of data and in
   writing the manuscript.
CR Armstrong K, 2020, J ALTERN COMPLEM MED, V26, P928, DOI 10.1089/acm.2019.0267
   Banach M, 2017, BRAIN BEHAV, V7, DOI 10.1002/brb3.558
   Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
   Bao T, 2012, MED ACUPUNCT, V24, P181, DOI 10.1089/acu.2011.0868
   Blossfeldt Patrick, 2004, Acupunct Med, V22, P146
   Bonhof CS, 2020, SUPPORT CARE CANCER, V28, P5933, DOI 10.1007/s00520-020-05438-5
   Brami C, 2016, CRIT REV ONCOL HEMAT, V98, P325, DOI 10.1016/j.critrevonc.2015.11.014
   British Acupuncture Council, 2021, US
   Cai RL, 2018, J INTEGR MED-JIM, V16, P26, DOI 10.1016/j.joim.2017.12.002
   Chien TJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419886662
   Desforges AD, 2022, BIOMED PHARMACOTHER, V147, DOI 10.1016/j.biopha.2022.112671
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   European Medicines Agency, 2016, Appendix 2 to the guideline on the evaluation of anticancer medicinal products in man: the use of patient-reported outcome (PRO) measures in oncology studies
   Franconi G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/516916
   Freed B, 2021, CLIN TRIALS, V18, P361, DOI 10.1177/1740774520984870
   Iravani S, 2020, PAIN RES MANAG, V2020, DOI 10.1155/2020/2504674
   Jeong YJ, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/5367014
   Jin YX, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8875433
   Jordan B, 2020, ANN ONCOL, V31, P1306, DOI 10.1016/j.annonc.2020.07.003
   Kolb NA, 2016, JAMA NEUROL, V73, P860, DOI 10.1001/jamaneurol.2016.0383
   Lai HC, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/6173412
   Li K, 2019, CURR ONCOL, V26, pE147, DOI 10.3747/co.26.4261
   Li QQ, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/267959
   Linde K, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007587.pub2
   Liu LZ, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/328196
   Loprinzi CL, 2020, J CLIN ONCOL, V38, DOI 10.1200/JCO.20.01399
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Molassiotis A, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-5302-4
   Molassiotis A, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419836501
   Paterson C, 1996, BRIT MED J, V312, P1016
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Seo Hyun-sik, 2020, [Journal of Korean Medicine, 대한한의학회지], V41, P88, DOI 10.13048/jkm.20047
   Vickers AJ, 2012, ARCH INTERN MED, V172, P1444, DOI 10.1001/archinternmed.2012.3654
   Winters-Stone KM, 2017, J CLIN ONCOL, V35, P2604, DOI 10.1200/JCO.2016.71.3552
   Zhang C, 2010, J TRADIT CHIN MED, V30, P13, DOI 10.1016/S0254-6272(10)60003-9
   Zhou W, 2014, J ACUPUNCT MERIDIAN, V7, P186
NR 36
TC 19
Z9 23
U1 3
U2 12
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1462-3889
EI 1532-2122
J9 EUR J ONCOL NURS
JI Eur. J. Oncol. Nurs.
PD OCT
PY 2022
VL 60
AR 102171
DI 10.1016/j.ejon.2022.102171
EA AUG 2022
PG 10
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA 4S1ZI
UT WOS:000857247400001
PM 35952460
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Schencking, M
   Kraft, K
AF Schencking, Martin
   Kraft, Karin
TI Inpatient Treatment for Postradical Neck Pain Syndrome by Use of
   Complementary Medicine
SO FORSCHENDE KOMPLEMENTARMEDIZIN
LA German
DT Article
DE Postradical neck pain syndrome; Thyroid cancer; Neuropathic pain;
   Allodynia; Naturopathic treatment; Hydrotherapy; Cantharidin blister
ID SHOULDER DYSFUNCTION; CERVICAL PLEXUS; DISSECTION; CANCER; AGE
AB Inpatient Treatment for Postradical Neck Pain Syndrome by Use of Complementary Medicine Introduction: The standard treatment of papillary thyroid cancer with a diameter >1 cm is thyroidectomy combined with a modified neck-dissection of the central (perithyroideal, prelaryngeal and tracheo-esophageal) lymph nodes and a consecutive radiation. Frequently, postoperative pain syndromes occur after this procedure. The so-called 'postradical neck pain syndrome' (PRNS) is a combination of cervical neuropathic pain, constricted and painful mobility of the shoulder region(s) including inhibited abduction capacity of the shoulder joint and a scapula alata. PRNS is often resistant to conventional therapy such as analgesics and physiotherapy. Case Report: A 56-year-old female inpatient, suffering from a severe PRNS after thyroidectomy and neck dissection due to papillary thyroid cancer for the past 2 years, was treated with a combination of hydrotherapy according to Kneipp, conventional physiotherapy, acupuncture and cantharidin blisters in order to reduce neuropathic pain, increase the range of cervical mobility and improve parameters of health-related quality of life (based on SF-36). Results: Within 4 weeks of combined treatment, the left-cervical neuropathic pain was improved remarkably, and the range of the cervical mobility was increased sufficiently. In addition, the SF-36 scales 'pain' and 'common well-being' were improved to a clinically relevant extent. The multi-modular treatment was well tolerated. Conclusions: In PRNS, a combination of several methods of complementary medicine may be an effective and well tolerated alternative to conventional treatment. Further clinical studies are required to confirm the results.
C1 [Schencking, Martin] Kneippsche Kliniken, Bad Worishofen, Germany.
   [Kraft, Karin] Univ Rostock, Klin & Poliklin Innere Med, Lehrstuhl Nat Heilkunde, D-2500 Rostock 1, Germany.
C3 University of Rostock
RP Schencking, M (corresponding author), Rheinstr 77A, D-56235 Ransbach Baumbach, Germany.
EM naturedoc@web.de
OI Schencking, Martin/0000-0002-0957-0996
CR Agha-Mir-Salim P, 2002, HNO, V50, P544, DOI 10.1007/s00106-001-0587-3
   Bullinger M, 1996, Rehabilitation (Stuttg), V35, pXVII
   Campos A, 1996, Acta Otorrinolaringol Esp, V47, P387
   Chen AY, 2009, CANCER-AM CANCER SOC, V115, P3801, DOI 10.1002/cncr.24416
   Cheng PT, 2000, ANN OTO RHINOL LARYN, V109, P761, DOI 10.1177/000348940010900811
   Cook MB, 2009, CANCER EPIDEM BIOMAR, V18, P1174, DOI 10.1158/1055-9965.EPI-08-1118
   Dilber M, 2007, EUR ARCH OTO-RHINO-L, V264, P1333, DOI 10.1007/s00405-007-0357-2
   Dorsher PT, 2008, J ALTERN COMPLEM MED, V14, P353, DOI 10.1089/acm.2007.0810
   Fleming Sara, 2007, BMC Complement Altern Med, V7, P15, DOI 10.1186/1472-6882-7-15
   Kilfoy BA, 2009, CANCER EPIDEM BIOMAR, V18, P1092, DOI 10.1158/1055-9965.EPI-08-0976
   Leenhardt L, 2009, J RADIOL, V90, P354, DOI 10.1016/S0221-0363(09)72520-X
   Manxhuka-Kerliu S, 2009, BOSNIAN J BASIC MED, V9, P111, DOI 10.17305/bjbms.2009.2829
   MATCJKA R, 2000, AUSLEITENDE THERAPIE, P123
   McNeely ML, 2008, CANCER, V113, P214, DOI 10.1002/cncr.23536
   Orhan KS, 2007, J LARYNGOL OTOL, V121, P44, DOI 10.1017/S0022215106002052
   PFISTER D, 2008, J CLIN ONCOL S
   PREISS J, 2006, ONKOLOGIE INTEGRATIV, V1, P590
   SCHENCKING M, 2009, NOTFALL HAUSARZTMED, V35, P352
   Schencking M, 2008, FORSCH KOMPLEMENTMED, V15, P273, DOI 10.1159/000159386
   Schencking M, 2009, FORSCH KOMPLEMENTMED, V16, P117, DOI 10.1159/000210561
   SIMONS DG, 2002, HDB MUSKEL TRIGGERPU, V2, P45
   Sist T, 1999, J PAIN SYMPTOM MANAG, V18, P95, DOI 10.1016/S0885-3924(99)00054-8
   Wittekindt C, 2006, LARYNGOSCOPE, V116, P1168, DOI 10.1097/01.mlg.0000217797.05523.75
NR 23
TC 0
Z9 0
U1 1
U2 18
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7096
J9 FORSCH KOMPLEMENTMED
JI Forsch. Komplement.med.
PY 2010
VL 17
IS 2
BP 81
EP 86
DI 10.1159/000287920
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 594YT
UT WOS:000277578300005
PM 20484915
DA 2026-01-16
ER

PT J
AU Ji, D
   Zhou, YL
   Li, SS
   Li, D
   Chen, H
   Xiong, YC
   Zhang, YQ
   Xu, H
AF Ji, Dong
   Zhou, Yalan
   Li, Shuangshuang
   Li, Dai
   Chen, Hui
   Xiong, Yuanchang
   Zhang, Yuqiu
   Xu, Hua
TI Anti-nociceptive effect of dexmedetomidine in a rat model of
   monoarthritis via suppression of the TLR4/NF-κB p65 pathway
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE dexmedetomidine; anti-nociceptive; inflammatory cytokine; signaling
   pathway
ID SPINAL GLIAL ACTIVATION; NF-KAPPA-B; PERIPHERAL-NERVE INJURY;
   NEUROPATHIC PAIN; PATHOLOGICAL PAIN; RECEPTOR; ELECTROACUPUNCTURE;
   MICROGLIA; AGONIST; PHOSPHORYLATION
AB As a therapeutic target for neuropathic pain, the anti-nociceptive effects of alpha 2-adrenoceptors (alpha 2AR) have attracted attention. Dexmedetomidine (DEX), a potent and highly selective alpha 2AR agonist, has exhibited significant analgesic effects in neuropathic pain, but the underlying mechanism has remained elusive. The present study investigated the effect of DEX on Toll-like receptor (TLR) 4 and nuclear factor (NF)-kappa B p65 expression, as well as the production of pro-inflammatory cytokines. The rat monoarthritis (MA) model was induced by intra-articular injection of complete Freund's adjuvant (CFA) at the ankle joint. After induction of MA, the rats were intrathecally treated with normal saline or DEX (2.5 mu g) for 3 consecutive days. The concentration of interleukin-1 beta and -6 as well as tumor necrosis factor-alpha was examined by ELISA. The expression levels of TLR4 and NF-kappa B p65 were determined by western blot analysis and immunohistochemistry. The results indicated that the pro-inflammatory cytokines TLR4 and NF-kappa B p65 were significantly upregulated in MA rats. DEX treatment markedly reduced mechanical and thermal hyperalgesia, suppressed MA-induced elevation of the pro-inflammatory cytokines and inhibited the TLR4/NF-kappa B p65 pathway, while these effects were blocked by pre-treatment with the selective alpha 2AR antagonist BRL44408 (15 mu g) at 30 min prior to CFA injection. These results suggested that DEX has an antinoci-ceptive effect via suppressing the TLR4/NF-kappa B p65 pathway.
C1 [Ji, Dong; Zhou, Yalan; Li, Shuangshuang; Li, Dai; Chen, Hui; Xiong, Yuanchang; Xu, Hua] Second Mil Med Univ, Changhai Hosp, Dept Anesthesiol, 168 Changhai Rd, Shanghai 200433, Peoples R China.
   [Zhang, Yuqiu] Fudan Univ, Inst Neurobiol, Inst Brain Sci, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China.
   [Zhang, Yuqiu] Fudan Univ, State Key Lab Med Neurobiol, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China.
C3 Naval Medical University; Fudan University; Fudan University
RP Xu, H (corresponding author), Second Mil Med Univ, Changhai Hosp, Dept Anesthesiol, 168 Changhai Rd, Shanghai 200433, Peoples R China.; Zhang, YQ (corresponding author), Fudan Univ, Inst Neurobiol, Inst Brain Sci, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China.; Zhang, YQ (corresponding author), Fudan Univ, State Key Lab Med Neurobiol, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China.
EM yuqiuzhang@fudan.edu.cn; pshhuaxu@163.com
OI Xu, Hua/0000-0001-5607-7742
CR Akira S, 2004, NAT REV IMMUNOL, V4, P499, DOI 10.1038/nri1391
   BAEUERLE PA, 1994, ANNU REV IMMUNOL, V12, P141, DOI 10.1146/annurev.iy.12.040194.001041
   BAEUERLE PA, 1988, SCIENCE, V242, P540, DOI 10.1126/science.3140380
   Bettoni I, 2008, GLIA, V56, P1312, DOI 10.1002/glia.20699
   Buerkle H, 1998, BRIT J ANAESTH, V81, P208, DOI 10.1093/bja/81.2.208
   Cao H, 2008, NEUROSCI BIOBEHAV R, V32, P972, DOI 10.1016/j.neubiorev.2008.03.009
   Chu YX, 2012, NEUROSCI BULL, V28, P49, DOI 10.1007/s12264-012-1058-4
   Conway EL, 1998, NEUROSCIENCE, V82, P805
   Feng YF, 2005, MOL CELL BIOL, V25, P4010, DOI 10.1128/MCB.25.10.4010-4022.2005
   GRILLI M, 1993, INT REV CYTOL, V143, P1
   Gwak YS, 2012, EXP NEUROL, V234, P362, DOI 10.1016/j.expneurol.2011.10.010
   HEAL DJ, 1993, EUR J PHARMACOL, V249, P37, DOI 10.1016/0014-2999(93)90659-6
   Ledeboer A, 2005, PAIN, V115, P71, DOI 10.1016/j.pain.2005.02.009
   Lee HG, 2013, NEUROSCI LETT, V557, P118, DOI 10.1016/j.neulet.2013.10.002
   Li SS, 2014, NEUROSCI LETT, V560, P21, DOI 10.1016/j.neulet.2013.12.012
   Liu L, 2012, BRAIN RES, V1427, P1, DOI 10.1016/j.brainres.2011.08.019
   Malmberg AB, 2001, BRIT J PHARMACOL, V132, P1827, DOI 10.1038/sj.bjp.0704032
   Milligan ED, 2003, J NEUROSCI, V23, P1026
   Mori K, 2002, NEUROPHARMACOLOGY, V43, P1026, DOI 10.1016/S0028-3908(02)00211-3
   O'Neill L, 2000, BIOCHEM SOC T, V28, P557, DOI 10.1042/bst0280557
   Paqueron X, 2003, ANESTHESIOLOGY, V99, P199, DOI 10.1097/00000542-200307000-00030
   Peng L, 2003, BRAIN RES, V978, P65, DOI 10.1016/S0006-8993(03)02766-5
   Pertovaara A, 2000, ANESTHESIOLOGY, V92, P1082, DOI 10.1097/00000542-200004000-00027
   Saito O, 2010, BRIT J PHARMACOL, V160, P1754, DOI 10.1111/j.1476-5381.2010.00811.x
   Schaible HG, 2002, ANN NY ACAD SCI, V966, P343, DOI 10.1111/j.1749-6632.2002.tb04234.x
   Shan S, 2007, NEUROBIOL DIS, V26, P558, DOI 10.1016/j.nbd.2007.02.007
   Shan S, 2007, PAIN, V129, P64, DOI 10.1016/j.pain.2006.09.035
   Shimode N, 2003, NEUROSCI LETT, V343, P45, DOI 10.1016/S0304-3940(03)00309-4
   Sun S, 2008, BRAIN RES BULL, V75, P83, DOI 10.1016/j.brainresbull.2007.07.027
   Sun S, 2006, EXP NEUROL, V198, P294, DOI 10.1016/j.expneurol.2005.11.011
   Tsuda M, 2005, TRENDS NEUROSCI, V28, P101, DOI 10.1016/j.tins.2004.12.002
   UNNERSTALL JR, 1984, BRAIN RES REV, V7, P69, DOI 10.1016/0165-0173(84)90030-4
   VIRTANEN R, 1988, EUR J PHARMACOL, V150, P9, DOI 10.1016/0014-2999(88)90744-3
   Watkins LR, 2001, TRENDS NEUROSCI, V24, P450, DOI 10.1016/S0166-2236(00)01854-3
   Wright Jeffrey G, 2003, Am J Respir Med, V2, P211
   Wu GJ, 2008, TOXICOL APPL PHARM, V228, P105, DOI 10.1016/j.taap.2007.11.027
   Wu YQ, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/562154
   Wu YQ, 2012, CELL PHYSIOL BIOCHEM, V30, P609, DOI 10.1159/000341442
   Xu B, 2010, CLIN EXP PHARMACOL P, V37, pe158, DOI 10.1111/j.1440-1681.2010.05426.x
   Xu B, 2010, ACTA PHARMACOL SIN, V31, P523, DOI 10.1038/aps.2010.32
   Xu JJ, 2006, ANESTH ANALG, V103, P714, DOI 10.1213/01.ane.0000226100.46866.ea
   Xu M, 2000, ANESTHESIOLOGY, V93, P473, DOI 10.1097/00000542-200008000-00027
   Yang JL, 2012, MOL BRAIN, V5, DOI 10.1186/1756-6606-5-18
NR 43
TC 16
Z9 17
U1 0
U2 6
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD NOV
PY 2017
VL 14
IS 5
BP 4910
EP 4918
DI 10.3892/etm.2017.5196
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FM4GS
UT WOS:000414973100132
PM 29201195
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Kong, S
   Zhang, YH
   Liu, CF
   Tsui, I
   Guo, Y
   Ai, BB
   Han, FJ
AF Kong, Sai
   Zhang, Yue-Hui
   Liu, Chen-Fang
   Tsui, Ilene
   Guo, Ying
   Ai, Bei-Bei
   Han, Feng-Juan
TI The Complementary and Alternative Medicine for Endometriosis: A Review
   of Utilization and Mechanism
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID TRADITIONAL CHINESE MEDICINE; WENSHEN XIAOZHENG TANG;
   TUMOR-NECROSIS-FACTOR; CELLS IN-VITRO; PERITONEAL-FLUID; CURCUMIN;
   RESVERATROL; WOMEN; ANGIOGENESIS; EXPRESSION
AB Endometriosis (EM) is one of the common gynecological conditions causing menstrual and pelvic pain and affects 10%-15% of women of reproductive age. In recent years, the complementary and alternative medical (CAM) treatment for EM has become popular due to the few adverse reactions reported. The CAM therapy for EM includes several different treatments such as herbs (herbal prescription, extract, and patent), acupuncture, microwave physiotherapy, and Chinese herb medicine enema (CHM enema). These CAM therapies are effective at relieving dysmenorrhoea, shrinking adnexal masses, and promoting pregnancy, with less unpleasant side effects when compared to hormonal and surgical treatments. In this review, we focus on the status quo of CAM on EM and try to identify therapeutic efficacy and mechanisms based on some clinical and experimental studies. We hope to provide some instructive suggestions for clinical treatment and experimental research in the future.
C1 [Kong, Sai; Liu, Chen-Fang; Guo, Ying; Ai, Bei-Bei] Heilongjiang Univ Chinese Med, Dept Obstet & Gynecol, Harbin 150040, Peoples R China.
   [Zhang, Yue-Hui; Han, Feng-Juan] Heilongjiang Univ Chinese Med, Dept Obstet & Gynecol, Affiliated Hosp 1, Harbin 150040, Peoples R China.
   [Zhang, Yue-Hui] Heilongjiang Univ Chinese Med, Ctr Postdoctoral Studies, Harbin 150040, Peoples R China.
   [Tsui, Ilene] Penn State Univ, Coll Med, Hershey, PA 17033 USA.
C3 Heilongjiang University of Chinese Medicine; Heilongjiang University of
   Chinese Medicine; Heilongjiang University of Chinese Medicine;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Han, FJ (corresponding author), Heilongjiang Univ Chinese Med, Dept Obstet & Gynecol, Affiliated Hosp 1, Harbin 150040, Peoples R China.
EM hanfengjuan2004@163.com
RI Zhang, Yuehui/H-7821-2013
OI Zhang, Yuehui/0000-0001-8517-7603
FU National Natural Science Fund of China [81273788]; Program for New
   Century Excellent Talents in Heilongjiang Provincial University
   [1155-NCET-015]
FX This paper is supported by the National Natural Science Fund of China
   (Grant no. 81273788); the Program for New Century Excellent Talents in
   Heilongjiang Provincial University (Grant no. 1155-NCET-015).
CR Altan ZM, 2010, J PHARMACOL EXP THER, V334, P460, DOI 10.1124/jpet.110.166488
   [Anonymous], FORUM TRADITIONAL CH
   Bai R. X., 1988, CHINESE J ORTHOPAEDI, V18, P290
   Barnes Patricia M, 2004, Adv Data, P1
   Batt RE, 2011, HISTORY OF ENDOMETRIOSIS, pXXIII, DOI 10.1007/978-0-85729-585-9
   Bruner-Tran KL, 2011, BIOL REPROD, V84, P106, DOI 10.1095/biolreprod.110.086744
   陈德甫, 2003, [中国中西医结合杂志, Chinese Journal of Integrated Traditional and Western Medicine], V23, P170
   Chen D. F., 1994, SHANGHAI J TRADITION, V28, P6
   [陈何红 CHEN Hehong], 2007, [北京中医药大学学报, Journal of Beijing University of Traditional Chinese Medicine], V30, P643
   Chen J. H., 2006, MODERN MED J CHINA, V8, P20
   Chen L. J., 2004, ACTA CHINESE MED PHA, V32, P39
   Chen L. N., 2011, SHANDONG J TRADITION, V30, P403
   Chen Ming, 2010, Zhongguo Zhen Jiu, V30, P725
   Chen Q., 1996, CHINESE ACUPUNCTURE, V2, P25
   [陈蓉 CHEN Rong], 2011, [中成药, Chinese Traditional Patent Medicine], V33, P1145
   [陈蓉 Chen Rong], 2010, [生殖与避孕, Reproduction and Contraception], V30, P659
   Chen Y, 2011, REPROD SCI, V18, P886, DOI 10.1177/1933719111398500
   Chen Yun-Fei, 2008, Zhongguo Zhen Jiu, V28, P675
   Cheng L., 1999, GUANGDONG MED J, V20, P565
   Cheng W, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045529
   Chiu JH, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/198584
   Coulter ID, 2004, MED J AUSTRALIA, V180, P587, DOI 10.5694/j.1326-5377.2004.tb06099.x
   Ding DF, 2013, J INTEGR MED-JIM, V11, P389, DOI 10.3736/jintegrmed2013039
   Dou C. R., 1998, J GANSU COLL TRADITI, V15, P25
   Du L. J., 2010, CHINESE REMEDIES CLI, V10, P655
   DUAN YH, 2007, ZHEJIANG J TRAD CHIN, V42, P168
   Ergenoglu AM, 2013, REPROD SCI, V20, P1230, DOI 10.1177/1933719113483014
   Evian Annual Reprod EVAR Workshop, 2011, HUM REPROD UPDATE, V17, P829, DOI 10.1093/humupd/dmr033
   Fang D. L., 2003, CLIN J ANHUI TRADITI, V15, P297
   Flower A, 2007, J ALTERN COMPLEM MED, V13, P969, DOI 10.1089/acm.2006.6283
   Fu B. J., 2008, SHANGHAI J TRADITION, V42, P53
   Fu JinRong Fu JinRong, 2012, Chinese Archives of Traditional Chinese Medicine, V30, P537
   FU Y, 2005, SHANGHAI J ACUPUNCTU, V24, P3
   Gao A. Z., 2012, GUANGMING J CHINESE, V27, P717
   Giudice LC, 2004, LANCET, V364, P1789, DOI 10.1016/S0140-6736(04)17403-5
   Gu J. H., 2003, J TRADITIONAL CHINES, V10, P301
   Guo SW, 2009, MOL HUM REPROD, V15, P609, DOI 10.1093/molehr/gap075
   Hawkins RS, 2003, APPL PSYCHOPHYS BIOF, V28, P279, DOI 10.1023/A:1027378825194
   Hua X. B., 1991, EXPT ANIMALS ANIMAL, V1, P1
   Huang ZH., 2007, CHIN J INTEGR TRADIT, V27, P748
   Hui X. L., 2009, J SHAANXI COLL TRADI, V32, P45
   Huo G. M., 2006, HUBEI J TRADITIONAL, V28, P8
   Jana S, 2012, INDIAN J BIOCHEM BIO, V49, P342
   Jana S, 2012, BIOCHEM PHARMACOL, V83, P797, DOI 10.1016/j.bcp.2011.12.030
   Ji XY, 2011, J ETHNOPHARMACOL, V134, P624, DOI 10.1016/j.jep.2011.01.003
   Jin Ya-bei, 2009, Zhen Ci Yan Jiu, V34, P188
   Kanaoka Yasushi, 2004, Osaka City Medical Journal, V50, P47
   Kellehear A, 2003, MED J AUSTRALIA, V179, pS46
   Kim KH, 2012, PHYTOTHER RES, V26, P1037, DOI 10.1002/ptr.3694
   KOIKE H, 1992, PROSTAG LEUKOTR ESS, V46, P133, DOI 10.1016/0952-3278(92)90219-9
   Koike H, 1994, Nihon Naibunpi Gakkai Zasshi, V70, P43
   Laschke MW, 2008, HUM REPROD, V23, P2308, DOI 10.1093/humrep/den245
   Lei X. P., 2002, PROGR PHYSL SCI, V33, P286
   Li J, 1999, Zhongguo Zhong Xi Yi Jie He Za Zhi, V19, P533
   Li S. P., 2009, SHAANXI J TRADITIONA, V25, P49
   Li W. L., 2009, MODERN TRADITIONAL C, V29, P19
   李兆艾, 2007, [中华妇产科杂志, Chinese Journal of Obstetrics and Gynecology], V42, P417
   Li Z. X., 2002, CHINESE J INTEGRATED, V22, P294
   Lin H. Y., 2009, SUZHOU U J MED SCI, V29, P636
   Lin YanMing Lin YanMing, 2012, Journal of Liaoning University of Traditional Chinese Medicine, V14, P73
   Liu H. Z., 2005, HERALD MED, V17, P566
   Liu Y. L., 2010, SHANDONG MED J, V50, P78
   Liu Y. Y., 2009, HUBEI J TRADITIONAL, V3, P53
   Long J. R., 2012, CHINESE REMEDIES CLI, V12, P720
   Loudon I, 2006, J ROY SOC MED, V99, P607, DOI 10.1258/jrsm.99.12.607
   LUO JY, 2006, MODERN J INTEGRATED, V15, P1626
   Ma M. Z., 1993, SHANGHAI J TRADITION, V2, P16
   [马文光 MA Wenguang], 2007, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V22, P879
   Maia H, 2012, INT J WOMENS HEALTH, V4, P543, DOI 10.2147/IJWH.S36825
   Meissner K, 2010, FORSCH KOMPLEMENTMED, V17, P314, DOI 10.1159/000322890
   Mu L. J., 2012, CHINESE MAT MED, V19, P80
   NIH Consensus Development Program, 2007, AC CONS DEV C STAT
   Pan L, 2011, B MED RES, V40, P126
   Partadiredja G, 2013, J INTEGR MED-JIM, V11, P32, DOI 10.3736/jintegrmed2013006
   Pino M, 2009, REPRODUCTION, V138, P837, DOI 10.1530/REP-09-0196
   Pujol LAM, 2007, J AM OSTEOPATH ASSOC, V107, pES15
   Qu F., 2006, J SICHUAN TRADITIONA, V12, P9
   Ren Y.L., 2005, J CHINESE PRACTICAL, V19, P279
   Rudzitis-Auth J, 2013, HUM REPROD, V28, P1339, DOI 10.1093/humrep/det031
   Ruhland B, 2011, Minerva Ginecol, V63, P247
   Scholl B, 2009, GYNECOL ENDOCRINOL, V25, P701, DOI 10.3109/09513590903159680
   Sharma B, 2004, J Obstet Gynaecol, V24, P916
   Sharpe-Timms KL, 2010, HUM REPROD, V25, P1241, DOI 10.1093/humrep/deq032
   She C., 2012, SHANGHAI J ACUPUNCTU, V31, P178
   [史淑红 SHI Shuhong], 2007, [中成药, Chinese Traditional Patent Medicine], V29, P788
   Si C. Q., 2012, HEBEI J TRADITIONAL, V34, P678
   Sinaii N, 2002, HUM REPROD, V17, P2715, DOI 10.1093/humrep/17.10.2715
   Song Z. Y., 2006, CHINESE REMEDIES CLI, V6, P255
   Song ZY, 2011, CHIN REM CLIN, V11, P768
   Sun Q. F., 2012, HUNAN J TRADITIONAL, V21, P62
   Sun Y. H., 2008, INFORM TRADITIONAL C, V25, P41
   Swarnakar S, 2009, INDIAN J BIOCHEM BIO, V46, P59
   Tang M.B., 2012, J PRACTICAL TRADITIO, V26, P66
   Tang Yong-jiu, 2005, Zhongguo Zhongyao Zazhi, V30, P1108
   The Cleveland Clinic, 2010, REC END SURG MAN END
   US National Center for Complementary and Alternative Medicine, 2006, AC
   Wang C. F., 2007, MODERN J INTEGRATED, V16, P1931
   Wang CC, 2013, ANGIOGENESIS, V16, P59, DOI 10.1007/s10456-012-9299-4
   Wang D, 1998, J Tradit Chin Med, V18, P7
   Wang D Z, 1991, Zhong Xi Yi Jie He Za Zhi, V11, P524
   Wang D, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025011
   Wang H. M., 2008, CHINESE J TRADITIONA, V15, P83
   Wang H. M., 2004, CHINESE J TRADITIONA, V11, P361
   Wang H. M., 2003, J FUJIAN COLL TRADIT, V13, P21
   Wang H. M., 2004, SHANGHAI J ACUPUNCTU, V23, P39
   Wang Q, 2009, J TRADIT CHIN MED, V29, P296, DOI 10.1016/S0254-6272(09)60088-1
   王雪, 2011, [广东医学, Guangdong Medical Journal], V32, P163
   Wang Y., 1997, STRAIT PHARM J, V9, P101
   [王自能 Wang Zineng], 2004, [中国病理生理杂志, Chinese Journal of Pathophysiology], V20, P862
   Wellbery C, 1999, AM FAM PHYSICIAN, V60, P1753
   Wickiewicz D, 2013, ARCH GYNECOL OBSTET, V288, P805, DOI 10.1007/s00404-013-2828-6
   Wu F., 2003, J CHINESE MICROCIRCU, V7, P355
   Wu Fan Wu Fan, 2003, Chinese Journal of Information on Traditional Chinese Medicine, V10, P29
   Wu HY, 2009, CHINA MODERN DOCTOR, V47, P77
   Wu X. H., 2011, GUANGMING J CHINESE, V26, P2467
   Xiang Dong-Fang, 2011, Zhongguo Zhen Jiu, V31, P113
   Xiao YH, 2002, EUR J GYNAECOL ONCOL, V23, P63
   Xu H, 2009, HUM REPROD, V24, P608, DOI 10.1093/humrep/den417
   Xu H, 2011, FERTIL STERIL, V96, P1021, DOI 10.1016/j.fertnstert.2011.07.008
   Xu K., 2007, CHINESE COMMUNITY DO, V23, P36
   Xu X. Y., 2011, MED INFORM, V24, P3172
   Xu X. Y., 2011, J SICHUAN TRADITIONA, V29, P28
   Yan X. H., 2004, FUJIAN J TRADITIONAL, V35, P11
   Yang Chun-Bo, 2008, Zhongguo Zhong Yao Za Zhi, V33, P567
   Yang F., 2011, SHAANXI J TRADITIONA, V32, P1557
   Yang J., 2005, SHAANXI J TRADITIONA, V26, P1007
   Yang J. B., 2007, YUNNAN J TRADITIONAL, V28, P36
   Yang J. B., 2008, CHINESE ARCH TRADITI, V26, P979
   Yang J. B., 2009, MODERN TRADITIONAL C, V29, P48
   Yang J. B., 2006, YUNNAN J TRADITIONAL, V27, P32
   Yang JQ, 2008, ITESS: 2008 PROCEEDINGS OF INFORMATION TECHNOLOGY AND ENVIRONMENTAL SYSTEM SCIENCES, PT 1, P1, DOI 10.1109/CVPR.2008.4587647
   Yang W. J., 1997, JIANGSU J TRADITIONA, V18, P22
   Yang YanHuan Yang YanHuan, 2012, China Journal of Traditional Chinese Medicine and Pharmacy, V27, P1911
   Yu B. J., 2009, CHINESE J MISDIAGNOS, V9, P2055
   Zeng R, 2010, Zhong Yi Za Zhi, V25, P342
   Zhang HQ, 2009, MODERN MED J CHINA, V11
   [张慧琴 Zhang Huiqin], 2011, [中医杂志, Journal of Traditional Chinese Medicine], V52, P27
   Zhang J. Y., 2008, ZHEJIANG J TRADITION, V43, P455
   Zhang L., 2007, CHINA MED HERALD, V4, P136
   Zhang L., 2007, J SICHUAN TRADITIONA, V25, P84
   Zhang P. H., 2012, J NEW CHINESE MED, V44, P60
   Zhang QinShu Zhang QinShu, 2012, Journal of Third Military Medical University, V34, P2167
   Zhang S. Y., 2011, CHINESE J ETHNOMEDIC, V22, P84
   Zhang W. J., 2004, SHAANXI J TRADITIONA, V5, P468
   Zhang Xi, 2009, Sichuan Da Xue Xue Bao Yi Xue Ban, V40, P228
   Zhang Y, 2011, INT J MOL MED, V27, P87, DOI 10.3892/ijmm.2010.552
   Zhang ZZ, 2013, CLIMACTERIC, V16, P700, DOI 10.3109/13697137.2013.771331
   Zhang ZZ, 2013, REPROD SCI, V20, P1215, DOI 10.1177/1933719113483008
   Zhao F., 2008, TRADITIONAL CHINESE, V21, P14
   [赵瑞华 Zhao Ruihua], 2012, [北京中医药大学学报, Journal of Beijing University of Traditional Chinese Medicine], V35, P826
   Zheng H., 2006, SHAANXI J TRADITIONA, V26, P1147
   Zheng H., 2005, LABELED IMMUNOASSAYS, V12, P35
   Zheng Hui, 2006, Zhongguo Zhong Xi Yi Jie He Za Zhi, V26 Suppl, P119
   Zhou S. Y., 2012, GUIDE CHINA MED, V10, P226
NR 154
TC 20
Z9 31
U1 1
U2 35
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2014
VL 2014
AR 146383
DI 10.1155/2014/146383
PG 16
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AC1YF
UT WOS:000332293200001
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Hall, M
   Bifano, SM
   Leibel, L
   Golding, LS
   Tsai, SL
AF Hall, Missy
   Bifano, Susanne M.
   Leibel, Leigh
   Golding, Linda S.
   Tsai, Shiu-Lin
TI The Elephant in the Room: The Need for Increased Integrative Therapies
   in Conventional Medical Settings
SO CHILDREN-BASEL
LA English
DT Article
DE Integrative therapies; art therapy; music therapy; yoga therapy;
   acupuncture; pastoral care; creative arts therapy; pediatrics
ID CHEMOTHERAPY-INDUCED NAUSEA; QUALITY-OF-LIFE; PEDIATRIC ONCOLOGY;
   BREAST-CANCER; ACUPUNCTURE; MULTICENTER; YOGA; PAIN
AB Pediatric integrative therapy programs are essential to the treatment and well-being of patients. Identifying an effective integrative therapy model within conventional pediatric medical settings, however, often proves difficult. Our goal in this article is to explore varied solutions to increase access and inclusion of integrative therapies in an effort to promote best practice and holistic care. The main methods applied in this article are vignettes that illustrate how the integrative therapies in a metropolitan academic hospital successfully treat the patient by complementing conventional medicine. This leads to comprehensive care. The central finding of the article proposes viable solutions to increase interdisciplinary collaboration both internally within the institution and externally. Integrative therapists detail how they were able to increase visibility and yield best practice through increased educational initiatives and interdisciplinary collaboration.
C1 [Hall, Missy; Bifano, Susanne M.] Columbia Univ, NewYork Presbyterian Morgan Stanley Childrens Hos, Child Life Dept, Med Ctr, 3959 Broadway, New York, NY 10032 USA.
   [Leibel, Leigh] Columbia Univ, Med Ctr, Div Hematol Oncol, 161 Ft Washington Ave,Suite 922, New York, NY 10032 USA.
   [Golding, Linda S.] Columbia Univ, Med Ctr, NewYork Presbyterian Milstein, Pastoral Care, 622 W 168th St, New York, NY 10032 USA.
   [Tsai, Shiu-Lin] Columbia Univ Coll Phys & Surg, Dept Emergency Med, Div Pediat Emergency Med, 3959 Broadway,CHN-W116, New York, NY 10032 USA.
C3 Cornell University; Weill Cornell Medicine; NewYork-Presbyterian
   Hospital; Morgan Stanley Children's Hospital; Columbia University;
   Columbia University; Columbia University; Columbia University
RP Hall, M (corresponding author), Columbia Univ, NewYork Presbyterian Morgan Stanley Childrens Hos, Child Life Dept, Med Ctr, 3959 Broadway, New York, NY 10032 USA.
EM mmh9010@nyp.org; sub9053@nyp.org; LL3125@cumc.columbia.edu;
   lig9048@nyp.org; st166@cumc.columbia.edu
RI Leibel, Leigh/ABH-5033-2020
OI Leibel, Leigh/0000-0002-6134-4355; Tsai, Shiu-Lin/0000-0003-1351-2542
CR Aguilar BA, 2017, J PEDIATR NURS, V36, P173, DOI 10.1016/j.pedn.2017.06.015
   [Anonymous], 2007, SCI DAILY
   [Anonymous], 2014, THESIS
   [Anonymous], PHYSIOTHERAPY
   Austin D., 1996, MUSIC THERAPY, V14, P29, DOI [DOI 10.1093/MT/14.1.29, 10.1093/mt/14.1.29]
   Boyd-Brewer Chris, 2004, Holist Nurs Pract, V18, P111
   Buber Martin., 2010, I and Thou
   Charon R, 2007, CAN FAM PHYSICIAN, V53, P1265
   Councill T., 2012, Handbook of art therapy, V2nd, P222
   Culos-Reed SN, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/642576
   Curry NA, 2005, ART THER, V22, P81, DOI 10.1080/07421656.2005.10129441
   Deng L., 2010, CHINESE ACUPUNCTURE
   DUNDEE JW, 1989, J ROY SOC MED, V82, P268, DOI 10.1177/014107688908200508
   Ezzo JM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002285.pub2
   Favara-Scacco C., 2005, ART THERAPY CANC CAR, P119
   FDA, 2017, ED BLUEPR HLTH CAR P
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   Kelly JA, 2016, J PALLIAT MED, V19, P763, DOI 10.1089/jpm.2015.0509
   Kieviet-Stijnen A, 2008, PATIENT EDUC COUNS, V72, P436, DOI 10.1016/j.pec.2008.05.015
   Kubler-Ross Elisabeth., 2005, GRIEF GRIEVING FINDI
   Landier W, 2010, J PEDIATR NURS, V25, P566, DOI 10.1016/j.pedn.2010.01.009
   Langevin HM, 2006, J CELL PHYSIOL, V207, P767, DOI 10.1002/jcp.20623
   Li QQ, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/267959
   Lin KY, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1155/2011/659876
   Lumley MA, 2011, J CLIN PSYCHOL, V67, P942, DOI 10.1002/jclp.20816
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Maeda Y, 2017, BRAIN, V140, P914, DOI 10.1093/brain/awx015
   McNutt J., 2012, ART THERAPY HEALTHCA, P127
   Mitchell P., CORE PRINCIPLES VALU
   Mustian KM, 2013, J CLIN ONCOL, V31, P3233, DOI 10.1200/JCO.2012.43.7707
   Nainis N, 2006, J PAIN SYMPTOM MANAG, V31, P162, DOI 10.1016/j.jpainsymman.2005.07.006
   Nolte Judith., 2005, Enhancing Interdisciplinary Collaboration in Primary Health Care in Canada
   Patrick G, 1999, IEEE ENG MED BIOL, V18, P97, DOI 10.1109/51.752987
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   Reindl TK, 2006, SUPPORT CARE CANCER, V14, P172, DOI 10.1007/s00520-005-0846-z
   Saxe J.G., 2009, POEMS J GODFREY SAXE
   Taso CJ, 2014, J NURS RES, V22, P155, DOI 10.1097/jnr.0000000000000044
   Thaut MH, 2015, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.01185
   Tsai SL, 2021, PEDIATR EMERG CARE, V37, pE360, DOI 10.1097/PEC.0000000000001619
   Tsai SL, 2015, MED ACUPUNCT, V27, P510, DOI 10.1089/acu.2015.1146
   Varni JW, 2007, J PEDIATR PSYCHOL, V32, P1151, DOI 10.1093/jpepsy/jsm008
   Weitzner MA, 1997, SUPPORT CARE CANCER, V5, P241, DOI 10.1007/s005200050067
   Wen J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100603
NR 43
TC 4
Z9 6
U1 0
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD NOV
PY 2018
VL 5
IS 11
AR 154
DI 10.3390/children5110154
PG 13
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA HB8BJ
UT WOS:000451308700012
PM 30453586
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, XC
   Shen, DL
   Shi, JL
   Gong, GW
   Wang, G
   Jiang, ZW
   Jin, HY
   Deng, ZM
AF Zhang, Xiao-Chun
   Shen, Dan-Li
   Shi, Jia-Ling
   Gong, Guan-Wen
   Wang, Gang
   Jiang, Zhi-Wei
   Jin, Hei-Ying
   Deng, Zheng-Ming
TI Development of a Nomogram for Predicting Postoperative Prolonged Ileus
   in Gastric Cancer Patients: A Retrospective and Prospective Cohort Study
SO AMERICAN SURGEON
LA English
DT Article; Early Access
DE postoperative ileus; gastric cancer; nomogram; risk prediction;
   electroacupuncture
ID INFLAMMATION; ACTIVATION; INFECTION
AB Objective To develop and validate a nomogram for predicting the risk of postoperative prolonged ileus (PPOI) in patients undergoing gastric cancer (GC) surgery, providing a personalized risk assessment tool for early identification and optimized postoperative management.Methods A retrospective cohort (January 2019-December 2023) was used to develop and internally test the nomogram, while a prospective cohort (January-December 2024) was used for external validation. Univariate and multivariate logistic regression with backward stepwise selection identified independent predictors. Model performance was assessed through receiver operating characteristic (ROC) curves, calibration curves, decision-curve analysis (DCA), and clinical impact curve analysis (CICA). Patients were stratified into low, medium, and high-risk groups based on nomogram scores for further analysis.Results A total of 780 patients in the training cohort and 294 in the validation cohort were included, with postoperative prolonged ileus rates of 11.54% and 16.33%, respectively (chi 2 = 4.371, P =.037). Independent predictors included electroacupuncture, pain self-efficacy questionnaire (PSEQ) score, preoperative serum albumin (Alb), body fat, postoperative day 1 Visual Analog Scale (Pod1 VAS), and intensive care unit (ICU) admission. The nomogram demonstrated strong discriminatory ability and calibration, with clinical utility confirmed through DCA and CICA. Higher nomogram scores correlated with increased PPOI incidence.Conclusions The developed nomogram is a valuable tool for early identification of PPOI in GC patients, supporting clinicians and nurses in implementing personalized preventive strategies.
C1 [Zhang, Xiao-Chun; Jin, Hei-Ying] Nanjing Univ Chinese Med, Affiliated Hosp 2, Dept Colorectal Surg, Nanjing, Peoples R China.
   [Shen, Dan-Li; Gong, Guan-Wen; Wang, Gang; Jiang, Zhi-Wei; Deng, Zheng-Ming] Nanjing Univ Chinese Med, Dept Gen Surg, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210023, Jiangsu, Peoples R China.
   [Shi, Jia-Ling] Nanjing Univ Chinese Med, Coll Nursing, Dept Surg Nursing, Nanjing, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine
RP Deng, ZM (corresponding author), Nanjing Univ Chinese Med, Dept Gen Surg, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210023, Jiangsu, Peoples R China.
EM dengzhengming2024@163.com
OI ZHANG, Xiaochun/0009-0000-3644-5333
FU Jiangsu Province 14th Five-Year medical key discipline: Traditional
   Chinese surgery [ZDXK202251]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This study was
   financially supported by Jiangsu Province 14th Five-Year medical key
   discipline: Traditional Chinese surgery (numbering: ZDXK202251).
CR Bik CK, 2016, J TRADIT CHIN MED, V36, P271, DOI 10.1016/S0254-6272(16)30038-3
   Buscail E, 2022, BRIT J PHARMACOL, V179, P3283, DOI 10.1111/bph.15800
   Chao Hui-Lin, 2013, Oncol Nurs Forum, V40, pE61, DOI 10.1188/13.ONF.E61-E68
   Chen KB, 2019, INT J SURG, V70, P93, DOI 10.1016/j.ijsu.2019.08.034
   Chung MY, 2011, J INT MED RES, V39, P2370, DOI 10.1177/147323001103900637
   Dubé MO, 2021, PAIN REP, V6, DOI 10.1097/PR9.0000000000000972
   Fan ZQ, 2024, BIOMARK MED, DOI 10.2217/bmm-2023-0355
   Gayer CP, 2009, CELL SIGNAL, V21, P1237, DOI 10.1016/j.cellsig.2009.02.011
   Hou LL, 2016, J TRADIT CHIN MED, V36, P450
   Ju H, 2024, KOREAN J ANESTHESIOL, V77, P133, DOI 10.4097/kja.22792
   Kalff JC, 2003, ANN SURG, V237, P301, DOI 10.1097/00000658-200303000-00003
   Khoury MK, 2024, J VASC SURG, V80, DOI 10.1016/j.jvs.2024.07.094
   Kim G, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0981-x
   Liang WQ, 2020, WORLD J GASTROENTERO, V26, P1185, DOI 10.3748/wjg.v26.i11.1185
   Liang WQ, 2019, WORLD J GASTROENTERO, V25, P5838, DOI 10.3748/wjg.v25.i38.5838
   Lieffers JR, 2012, BRIT J CANCER, V107, P931, DOI 10.1038/bjc.2012.350
   Lin ZM, 2022, BMC CANCER, V22, DOI 10.1186/s12885-022-10377-x
   Pei LX, 2025, GASTROENTEROLOGY, V169, P73, DOI [10.1053/j.gastro.2025.02.006, 10.1053/j.gastro.2025.02.006]
   Petch-in P, 2023, DRUGS-REAL WOR OUTC, V10, P341, DOI 10.1007/s40801-023-00364-4
   Ross RK, 2020, AM J EPIDEMIOL, V189, P1583, DOI 10.1093/aje/kwaa124
   Sasaki M, 2022, BMC SURG, V22, DOI 10.1186/s12893-022-01887-3
   Sparreboom CL, 2016, WORLD J GASTROENTERO, V22, P7226, DOI 10.3748/wjg.v22.i32.7226
   Sui C, 2025, FRONT IMMUNOL, V16, DOI 10.3389/fimmu.2025.1552944
   Tang XD, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222313009
   The FO, 2008, GUT, V57, P33, DOI 10.1136/gut.2007.120238
   Vather R, 2014, CLIN EXP PHARMACOL P, V41, P358, DOI 10.1111/1440-1681.12220
   Vather R, 2013, J GASTROINTEST SURG, V17, P962, DOI 10.1007/s11605-013-2148-y
   Wang Y, 2023, JAMA SURG, V158, P20, DOI 10.1001/jamasurg.2022.5674
   Wang ZB, 2024, FRONT NUTR, V11, DOI 10.3389/fnut.2024.1345570
   Wick EC, 2017, JAMA SURG, V152, P691, DOI 10.1001/jamasurg.2017.0898
   Xiu WC, 2024, INT J COLORECTAL DIS, V39, DOI 10.1007/s00384-024-04693-w
   Yang NN, 2021, THERANOSTICS, V11, P4078, DOI 10.7150/thno.52574
NR 32
TC 0
Z9 0
U1 2
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD 2025 SEP 29
PY 2025
DI 10.1177/00031348251383475
EA SEP 2025
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8AL5T
UT WOS:001584001900001
PM 41021978
DA 2026-01-16
ER

PT J
AU Bauer-Büntzel, C
   Büntzel, J
AF Bauer-Buntzel, Christoph
   Buntzel, Judith
TI Complementary approaches to treating radiation-induced side effects in
   the pelvis and chemotherapy-associated neuropathy
SO ONKOLOGIE
LA German
DT Review; Early Access
DE Neuropathic pain; Pelvic organ toxicity after radiotherapy; Peripheral
   nerve damage; Integrative oncology; Integrative oncology; Pelvic organ
   toxicity after radiotherapy; Peripheral nerve damage; Supportive care;
   Integrative oncology
ID PLACEBO-CONTROLLED TRIAL; INDUCED PERIPHERAL NEUROPATHY; DOUBLE-BLIND;
   BREAST-CANCER; RADIOTHERAPY; MULTICENTER; PREVENTION; WOMEN
AB Background: In uro-oncological diseases such as prostate cancer and urothelial carcinoma, multimodal treatment concepts combining radiation and systemic therapy are frequently applied. These approaches often lead to radiogenic side effects in the pelvis and chemotherapy-induced peripheral neuropathies (CIPN). Complementary and integrative medicine is increasingly used to alleviate therapy-related toxicities. Methods: Based on current German S3 guidelines and published clinical studies, complementary and integrative approaches for managing radiogenic adverse effects and CIPN were reviewed and evaluated for evidence and clinical relevance. Results: For radiogenic proctitis, enteritis, and cystitis, amifostine, probiotic combinations, and selenium showed beneficial effects, while Aloe vera may provide symptom relief. Cranberries are not recommended due to negative trial results. In CIPN, functional training and cryotherapy appear effective in prevention. Acupuncture and topical phytotherapeutics such as menthol, capsaicin, or Nigella sativa can reduce neuropathic pain. Vitamin E and carnitine are not indicated due to lack of efficacy. Conclusion: Complementary approaches can meaningfully contribute to alleviating therapy-related adverse effects. Their evidence-based integration into supportive oncology may improve quality of life and treatment tolerance in cancer patients.
C1 [Bauer-Buntzel, Christoph] Klinikum Fulda, Med Klin Nephrol 3, Fulda, Germany.
   [Buntzel, Judith] Univ Med Gottingen, Klin Hamatol & Med Onkol, Robert Koch Str 40, D-37075 Gottingen, Germany.
C3 Klinikum Fulda; University of Gottingen
RP Büntzel, J (corresponding author), Univ Med Gottingen, Klin Hamatol & Med Onkol, Robert Koch Str 40, D-37075 Gottingen, Germany.
EM judith.buentzel@med.uni-goettingen.de
RI Buentzel, Judith/AAK-7850-2021
CR [Anonymous], Urothelkarzinom (Harnblasenkarzinom)
   Athanassiou H, 2003, INT J RADIAT ONCOL, V56, P1154, DOI 10.1016/S0360-3016(03)00187-1
   AWMF, 2025, S3-Leitlinie Komplementarmedizin in der Behandlung von onkologischen PatientInnen. AWMF Langversion 2.0:630
   Bairati I, 2005, JNCI-J NATL CANCER I, V97, P481, DOI 10.1093/jnci/dji095
   Bauer-Büntzel C, 2024, Zeitschrift für Komplementärmedizin, V16, P16, DOI [10.1055/a-2284-0057, 10.1055/a-2284-0057, DOI 10.1055/A-2284-0057]
   Bland KA, 2019, CLIN BREAST CANCER, V19, P411, DOI 10.1016/j.clbc.2019.05.013
   Bonetta Alberto, 2012, Cancer Manag Res, V4, P281, DOI 10.2147/CMAR.S35342
   Chitapanarux I, 2010, RADIAT ONCOL, V5, DOI 10.1186/1748-717X-5-31
   Cowan CC, 2012, CLIN ONCOL-UK, V24, pE31, DOI 10.1016/j.clon.2011.05.009
   Dalsania Raj M, 2021, Am Soc Clin Oncol Educ Book, V41, P1, DOI [10.1200/edbk_323525, 10.1200/EDBK_323525]
   Deutsche Gesellschaft fur Urologie e. V, 2024, S3-Leitlinie Epidemiologie, Diagnostik, Therapie, Pravention und Management unkomplizierter, bakterieller, ambulant erworbener Harnwegsinfektionen bei Erwachsenen (HWI), P231
   Deutschen Krebshilfe (DKH), 2025, S3-Leitlinie Supportive Therapie bei onkologischen PatientInnen-Langversion 2.0
   Ehrenpreis ED, 2005, DIS COLON RECTUM, V48, P1, DOI 10.1007/s10350-004-0821-7
   Emami H, 2014, J RES MED SCI, V19, P445
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Guo SN, 2023, J CANCER SURVIV, V17, P318, DOI 10.1007/s11764-022-01182-3
   Helissey C, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10010021
   Hershman DL, 2013, J CLIN ONCOL, V31, P2627, DOI 10.1200/JCO.2012.44.8738
   Herst PM, 2020, RADIOTHER ONCOL, V149, P117, DOI 10.1016/j.radonc.2020.05.006
   Huber R., 2019, Mind-Maps Phytotherapie, DOI [10.1055/b-006-163252, DOI 10.1055/B-006-163252]
   Huebner J, 2014, BREAST CARE, V9, P60, DOI 10.1159/000360381
   Ju ZY, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012057.pub2
   Katsanos KH, 2010, J EXP CLIN CANC RES, V29, DOI 10.1186/1756-9966-29-68
   Khodaie SA, 2023, INFLAMMOPHARMACOLOGY, V31, P2885, DOI 10.1007/s10787-023-01338-2
   Kleckner IR, 2018, SUPPORT CARE CANCER, V26, P1019, DOI 10.1007/s00520-017-4013-0
   Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft Deutsche Krebshilfe AWMF), 2025, S3-Leitlinie Prostatakarzinom. Langversion 81, 2025 AWMF-Registernummer: 043-022OL
   Linn YH, 2019, PROBIOTICS ANTIMICRO, V11, P638, DOI 10.1007/s12602-018-9408-9
   Lube-Diedrich B., 2020, Arzneipflanzen-Arzneidrogen: Botanik-Eigenschaften-Anwendung. Avoxa-Mediengruppe Deutscher
   Molassiotis A, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419836501
   Muecke R, 2014, INTEGR CANCER THER, V13, P463, DOI 10.1177/1534735414541963
   Muecke R, 2010, INT J RADIAT ONCOL, V78, P828, DOI 10.1016/j.ijrobp.2009.08.013
   OTCHY DP, 1993, SURG CLIN N AM, V73, P1017
   Ronconi G, 2024, EUR J PHYS REHAB MED, V60, P505, DOI 10.23736/S1973-9087.24.08197-8
   Rosenbaek F, 2020, SUPPORT CARE CANCER, V28, P3763, DOI 10.1007/s00520-019-05196-z
   Sahebnasagh A, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-02935-2
   Shigematsu H, 2020, SUPPORT CARE CANCER, V28, P5005, DOI 10.1007/s00520-020-05345-9
   Simpson DM, 2017, J PAIN, V18, P42, DOI 10.1016/j.jpain.2016.09.008
   Wedlake L, 2017, AM J CLIN NUTR, V106, P849, DOI 10.3945/ajcn.116.150565
   Wiese F, 2023, INT J VITAM NUTR RES, V93, P72, DOI 10.1024/0300-9831/a000698
NR 39
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2731-7226
EI 2731-7234
J9 ONKOLOGIE-GER
JI Onkologie
PD 2025 DEC 15
PY 2025
DI 10.1007/s00761-025-01874-2
EA DEC 2025
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA W5237
UT WOS:001639688900001
OA Bronze
DA 2026-01-16
ER

PT J
AU Viscuse, PV
   Price, K
   Millstine, D
   Bhagra, A
   Bauer, B
   Ruddy, KJ
AF Viscuse, Paul V.
   Price, Katharine
   Millstine, Denise
   Bhagra, Anjali
   Bauer, Brent
   Ruddy, Kathryn J.
TI Integrative medicine in cancer survivors
SO CURRENT OPINION IN ONCOLOGY
LA English
DT Review
DE cancer; complementary alternative medicine; integrative medicine;
   survivorship
ID VITAMIN-D SUPPLEMENTATION; QUALITY-OF-LIFE; BREAST-CANCER;
   PHYSICAL-ACTIVITY; STRESS REDUCTION; MASSAGE THERAPY; PILOT TRIAL;
   FOLLOW-UP; RISK; INTERVENTION
AB Purpose of reviewDue to medical advances and an aging population, the number of cancer survivors continues to rise. Survivors often experience late and long-term sequelae of cancer and its treatment (e.g., fatigue, pain, fear of recurrence, and stress). As a result, some patients have utilized or expressed interest in integrative medicine (IM) modalities for prevention of recurrence, optimizing health, enhancing quality of life, and managing symptoms. The purpose of this review is to focus on research published during the past year that informs our understanding of the utility of IM for cancer survivors.Recent findingsPhysical activity, diet, dietary supplements, mind-body modalities, acupuncture, and massage therapy all may play a role in the management of the physical (e.g., fatigue and pain) and emotional (e.g., anxiety and fear) issues faced by cancer survivors.SummaryIM therapies are appealing to and utilized by many cancer survivors and may reduce symptom burden. Clinicians who provide cancer survivorship care may improve patient care by understanding the evidence for and against their use.
C1 [Viscuse, Paul V.; Bhagra, Anjali; Bauer, Brent] Mayo Clin, Dept Med, Rochester, MN USA.
   [Price, Katharine; Ruddy, Kathryn J.] Mayo Clin, Div Med Oncol, Rochester, MN 55905 USA.
   [Millstine, Denise] Mayo Clin, Div Womens Hlth Internal Med, Scottsdale, AZ USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic Phoenix
RP Ruddy, KJ (corresponding author), Mayo Clin, Div Med Oncol, Rochester, MN 55905 USA.
EM ruddy.kathryn@mayo.edu
RI Viscuse, Paul/HNS-8841-2023
OI Viscuse, Paul/0000-0003-0834-8688
FU CTSA Grant Program from National Center for Advancing Translational
   Sciences (NCATS) of the NIH [UL1 TR000135, KL2TR000136-09]
FX K.R. was supported by a training grant under the CTSA Grant Program
   Numbers UL1 TR000135 and KL2TR000136-09 from the National Center for
   Advancing Translational Sciences (NCATS) of the NIH. The contents of
   this manuscript are solely the responsibility of the authors and do not
   necessarily represent the official view of NIH.
CR American Cancer Society, 2014, CANC TREAT SURV FACT
   [Anonymous], J BEHAV MED
   Arthur AE, 2016, J CANCER SURVIV, V10, P981, DOI 10.1007/s11764-016-0544-5
   Arthur AE, 2014, CANCER-AM CANCER SOC, V120, P2704, DOI 10.1002/cncr.28778
   Barak-Nahum A, 2016, SOC SCI MED, V166, P1, DOI 10.1016/j.socscimed.2016.07.046
   Blair CK, 2016, J CANCER SURVIV, V10, P103, DOI 10.1007/s11764-015-0456-9
   Boyd C, 2016, PAIN MED, V17, P1553, DOI 10.1093/pm/pnw100
   Braden BB, 2016, BRAIN BEHAV, V6, DOI 10.1002/brb3.443
   Byrd D, 2017, J RACIAL ETHN HLTH D
   Carpenter J, 2015, MENOPAUSE, V22, P1155, DOI 10.1097/GME.0000000000000546
   Choi T, 2016, INTEGR CANC THER
   Cutshall SM, 2015, SUPPORT CARE CANCER, V23, P2989, DOI 10.1007/s00520-015-2666-0
   Davis EL, 2012, ONCOLOGIST, V17, P1475, DOI 10.1634/theoncologist.2012-0223
   Deng Gary E, 2009, J Soc Integr Oncol, V7, P85
   Denlinger CS, 2014, J NATL COMPR CANC NE, V12, P1396, DOI 10.6004/jnccn.2014.0137
   Donoyama N, 2016, GYNECOL ONCOL, V142, P531, DOI 10.1016/j.ygyno.2016.06.022
   Elkins G, 2008, J CLIN ONCOL, V26, P5022, DOI 10.1200/JCO.2008.16.6389
   Elkins G, 2010, CURR TREAT OPTION ON, V11, P128, DOI 10.1007/s11864-010-0129-x
   Gaskin CJ, 2016, CANCER CAUSE CONTROL, V27, P1093, DOI 10.1007/s10552-016-0787-5
   Hagstrom AD, 2016, EUR J CANCER CARE, V25, P784, DOI 10.1111/ecc.12422
   Hall AE, 2016, SUPPORT CARE CANCER, V24, P4413, DOI 10.1007/s00520-016-3282-3
   Hu C, 2016, J EVID-BASED INTEGR, V2016, P1, DOI DOI 10.1155/2016/1720239
   Irwin M, 2016, CANCER, V123, P1249
   Irwin ML, 2008, J CLIN ONCOL, V26, P3958, DOI 10.1200/JCO.2007.15.9822
   Jahnke Roger, 2010, Am J Health Promot, V24, pe1, DOI 10.4278/ajhp.081013-LIT-248
   Janelsins MC, 2016, INTEGR CANCER THER, V15, P263, DOI 10.1177/1534735415617021
   Johns SA, 2016, SUPPORT CARE CANCER, V24, P4085, DOI 10.1007/s00520-016-3220-4
   Kampshoff CS, 2016, SUPPORT CARE CANCER, V24, P3333, DOI 10.1007/s00520-016-3148-8
   Kelley GA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129181
   Kenfield SA, 2014, EUR UROL, V65, P887, DOI 10.1016/j.eururo.2013.08.009
   Kimman ML, 2017, BMC MED, V15, DOI 10.1186/s12916-016-0768-2
   Kroenke CH, 2005, J CLIN ONCOL, V23, P9295, DOI 10.1200/JCO.2005.02.0198
   Kushi LH, 2012, CA-CANCER J CLIN, V62, P30, DOI 10.3322/caac.20140
   Larkey LK, 2016, COMPLEMENT THER MED, V29, P196, DOI 10.1016/j.ctim.2016.10.006
   Lee PLT, 2016, COMPLEMENT THER MED, V27, P87, DOI 10.1016/j.ctim.2016.06.003
   Lengacher CA, 2016, J CLIN ONCOL, V34, P2827, DOI 10.1200/JCO.2015.65.7874
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Lewis C, 2016, SUPPORT CARE CANCER, V24, P1655, DOI 10.1007/s00520-015-2945-9
   Ligibel JA, 2008, J CLIN ONCOL, V26, P907, DOI 10.1200/JCO.2007.12.7357
   McCullough ML, 2011, CANCER EPIDEM BIOMAR, V20, P1089, DOI 10.1158/1055-9965.EPI-10-1173
   Mendoza ME, 2016, PSYCHOONCOLOGY
   Merckaert I, 2016, PSYCHOONCOLOGY
   Omenn GS, 1996, NEW ENGL J MED, V334, P1150, DOI 10.1056/NEJM199605023341802
   Ornish D, 2013, LANCET ONCOL, V14, P1112, DOI 10.1016/S1470-2045(13)70366-8
   Rock CL, 2012, CA-CANCER J CLIN, V62, P243, DOI 10.3322/caac.21142
   Rogers LQ, 2016, BREAST CANCER RES TR, V159, P283, DOI 10.1007/s10549-016-3945-2
   Salehi A, 2016, SUPPORT CARE CANCER, V24, P4895, DOI 10.1007/s00520-016-3345-5
   Schleithoff SS, 2006, AM J CLIN NUTR, V83, P754, DOI 10.1093/ajcn/83.4.754
   Shapiro AC, 2016, BREAST CANCER RES TR, V155, P501, DOI 10.1007/s10549-016-3710-6
   Simonavice E, 2017, SUPPORT CARE CANCER, V25, P9, DOI 10.1007/s00520-016-3374-0
   Spees CK, 2016, CANCER CONTROL, V23, P302, DOI 10.1177/107327481602300314
   Stan DL, 2016, SUPPORT CARE CANCER, V24, P4005, DOI 10.1007/s00520-016-3233-z
   Stanton AL, 2015, ADV EXP MED BIOL, V862, P231, DOI 10.1007/978-3-319-16366-6_15
   Strasser B, 2013, MED SCI SPORT EXER, V45, P2080, DOI 10.1249/MSS.0b013e31829a3b63
   Ulitsky A, 2011, JPEN-PARENTER ENTER, V35, P308, DOI 10.1177/0148607110381267
   van Roekel Eline H, 2016, Prev Med Rep, V4, P262, DOI [10.1016/j.pmedr.2016.06.022, 10.1016/j.pmedr.2016.06.022]
   van Roekel EH, 2016, CANCER CAUSE CONTROL, V27, P513, DOI 10.1007/s10552-016-0725-6
   Wang L, 2016, SCI REP-UK, V6, DOI 10.1038/srep38962
   Watson E, 2016, BJU INT, V117, pE10, DOI 10.1111/bju.13122
   Yao C, 2016, CURR ONCOL, V23, pE27, DOI 10.3747/co.23.2788
   Zeng YC, 2014, COMPLEMENT THER MED, V22, P173, DOI 10.1016/j.ctim.2013.11.010
   Zick SM, 2016, JAMA ONCOL, V2, P1470, DOI 10.1001/jamaoncol.2016.1867
   Zick SM, 2017, BREAST CANCER RES TR, V161, P299, DOI 10.1007/s10549-016-4070-y
NR 63
TC 32
Z9 39
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8746
EI 1531-703X
J9 CURR OPIN ONCOL
JI Curr. Opin. Oncol.
PD JUL
PY 2017
VL 29
IS 4
BP 235
EP 242
DI 10.1097/CCO.0000000000000376
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA EX2WM
UT WOS:000403091400003
PM 28459738
DA 2026-01-16
ER

PT J
AU Wang, Z
   Xu, H
   Wang, Z
   Zhou, H
   Diao, JY
   Zhang, LJ
   Wang, Y
   Li, MX
   Zhou, YF
AF Wang, Zhen
   Xu, Hui
   Wang, Zheng
   Zhou, Hang
   Diao, Jieyao
   Zhang, Lijuan
   Wang, Yu
   Li, Miaoxiu
   Zhou, Yunfeng
TI Effects of externally-applied, non-pharmacological Interventions on
   short- and long-term symptoms and inflammatory cytokine levels in
   patients with knee osteoarthritis: a systematic review and network
   meta-analysis
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE knee osteoarthritis; externally-applied; non-pharmacological
   interventions; short- and long-term; efficacy; inflammatory cytokine;
   network meta-analysis
ID PLATELET-RICH PLASMA; DOUBLE-BLIND; LASER ACUPUNCTURE; HYALURONIC-ACID;
   INTRAARTICULAR INJECTION; SYNOVIAL-FLUID; PAIN; EFFICACY; MANAGEMENT;
   THERAPY
AB Background: With the continuous development of clinical medicine, an increasing number of non-pharmacological interventions have been applied for the treatment of knee osteoarthritis (KOA), with the results of several recent randomized controlled trials (RCTs) showing that a variety of externally-applied, non-pharmacological interventions (EANPI) can improve symptoms and inflammation in patients with KOA. However, the relative benefits and disadvantages of non-drug therapies remain uncertain, and an optimal treatment strategy has not yet been determined.Objective: This study applied network meta-analysis (NMA) to compare and rank the effectiveness of EANPI on the short- and long-term clinical symptoms and inflammatory cytokine levels in patients with KOA.Methods Two independent researchers searched online databases and performed manual retrieval of related citations to identify RCTs that met the selection criteria for the network meta-analysis. These researchers retrieved studies indexed from database inception to August 2023 and performed data extraction and assessment of the risk of bias.Results: The analysis included 80 RCTs involving 8440 participants and nine externally-applied, non-pharmacological therapies, namely extracorporeal shock wave, radiofrequency, acupotomy, laser therapy, Tuina therapy, kinesio taping, electroacupuncture, platelet-rich plasma injection, and ozone therapy. The treatment courses ranged from 1 to 12 weeks, with follow-up periods ranging from 4 to 24 weeks. The results of the NMA indicated that each non-drug therapy was superior to sham intervention in improving all outcome indicators. Except for the visual analog scale (VAS) and Western Ontario MacMaster (WOMAC) pain outcomes, all non-drug therapies had better efficacy than pharmacological treatments. For short-term VAS and tumor necrosis factor-alpha (TNF-alpha), extracorporeal shock wave performed better than other therapies (90.2% and 85.2% respectively). Radiofrequency therapy may be the most promising method to reduce long-term VAS, short- and long-term WOMAC pain, and interleukin (IL)-1 beta level (84.8%, 97.8%, 90.1%, 94.8% respectively). Tuina therapy may be a significant choice for short- and long-term outcomes of WOMAC function and range of motion (ROM).Conclusions: The results of the comprehensive comparison of the outcome indicators in 9 different EANPI indicated that radiofrequency and Tuina therapy were more effective and consistently ranked high in improving clinical symptoms in the short and long term. Radiofrequency is effective at relieving pain, and Tuina therapy can be given priority for treatment when hypofunction is the main symptom. EANPI to improve pain symptoms may be related to the regulation of inflammatory cytokine levels, which may be a potential mechanism of action.Systematic review registration https://www.crd.york.ac.uk/prospero/display_record.php?, identifier CRD42023464177.
C1 [Wang, Zhen; Xu, Hui; Wang, Zheng; Zhou, Hang; Diao, Jieyao; Zhou, Yunfeng] Henan Univ Chinese Med, Coll Acupuncture & Massage, Zhengzhou, Peoples R China.
   [Xu, Hui] Henan Univ Chinese Med, Affiliated Hosp 3, Tuina Dept, Zhengzhou, Peoples R China.
   [Zhang, Lijuan] Jiaozuo Coal Ind Grp Co Ltd, Rehabil Dept, Cent Hosp, Jiaozuo, Peoples R China.
   [Wang, Yu] Xidian Univ, Coll Comp Sci, Xian, Peoples R China.
   [Li, Miaoxiu] Shanghai Univ Chinese Med, Coll Acupuncture & Massage, Shanghai, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Henan University of
   Traditional Chinese Medicine; Xidian University; Shanghai University of
   Traditional Chinese Medicine
RP Zhou, YF (corresponding author), Henan Univ Chinese Med, Coll Acupuncture & Massage, Zhengzhou, Peoples R China.
EM zyf5680198@126.com
FU Henan Province Chinese Medicine Scientific Research Special project
   [2022ZY1108]; Central Plains Thousand Talents Program-Central Plains
   Famous Doctors [ZYQR201912120]; 2022 Central Plains Talent Plan (Talent
   Education Series)-Central Plains Youth Top Talent Project [2022, 5];
   Henan Province Science and Technology Research-Social Development
   Project [222102310214]; Henan Provincial Science and Technology R&D
   Program Joint Fund (superior discipline cultivation category)
   [222301420061]; Henan Province key research and development and
   promotion special project (science and technology research)
   [232102311203]; Henan Province Traditional Chinese Medicine "Double
   First-Class" Scientific Research Project [HSRP-DFCTCM-2023-7-09]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the Henan Province Chinese Medicine Scientific Research Special
   project (No. 2022ZY1108), the Central Plains Thousand Talents
   Program-Central Plains Famous Doctors (No. ZYQR201912120), the 2022
   Central Plains Talent Plan (Talent Education Series)-Central Plains
   Youth Top Talent Project (No. Yu Talent Office [2022] No. 5), the Henan
   Province Science and Technology Research-Social Development Project (No.
   222102310214), the Henan Provincial Science and Technology R&D Program
   Joint Fund (superior discipline cultivation category) (No.
   222301420061), Henan Province key research and development and promotion
   special project (science and technology research)(No. 232102311203), and
   Henan Province Traditional Chinese Medicine "Double First-Class"
   Scientific Research Project (No. HSRP-DFCTCM-2023-7-09).r The author(s)
   declare financial support was received for the research, authorship,
   and/or publication of this article. This work was supported by the Henan
   Province Chinese Medicine Scientific Research Special project (No.
   2022ZY1108), the Central Plains Thousand Talents Program-Central Plains
   Famous Doctors (No. ZYQR201912120), the 2022 Central Plains Talent Plan
   (Talent Education Series)-Central Plains Youth Top Talent Project (No.
   Yu Talent Office [2022] No. 5), the Henan Province Science and
   Technology Research-Social Development Project (No. 222102310214), the
   Henan Provincial Science and Technology R&D Program Joint Fund (superior
   discipline cultivation category) (No. 222301420061), Henan Province key
   research and development and promotion special project (science and
   technology research)(No. 232102311203), and Henan Province Traditional
   Chinese Medicine "Double First-Class" Scientific Research Project (No.
   HSRP-DFCTCM-2023-7-09).
CR Acosta-Olivo C, 2014, CIR CIR, V82, P137
   Adatia A, 2012, J PHARM PHARMACOL, V64, P617, DOI 10.1111/j.2042-7158.2012.01458.x
   Ahmad MA, 2022, PHYSIOTHERAPY, V114, P85, DOI 10.1016/j.physio.2021.03.011
   Alghadir A, 2014, LASER MED SCI, V29, P749, DOI 10.1007/s10103-013-1393-3
   Anandkumar S, 2014, PHYSIOTHER THEOR PR, V30, P375, DOI 10.3109/09593985.2014.896963
   [Anonymous], 2017, J Neck Low Back Pain
   [Anonymous], 2017, Chin J Bone Joint Injury
   Arai T, 2022, BMC MUSCULOSKEL DIS, V23, DOI 10.1186/s12891-022-05937-y
   Babaei-Ghazani A, 2018, CLIN RHEUMATOL, V37, P2517, DOI 10.1007/s10067-018-4147-6
   Bannuru RR, 2019, OSTEOARTHR CARTILAGE, V27, P1578, DOI 10.1016/j.joca.2019.06.011
   Bennell KL, 2021, JAMA-J AM MED ASSOC, V326, P2021, DOI 10.1001/jama.2021.19415
   BERTAZZOLO N, 1994, AGENTS ACTIONS, V41, P90, DOI 10.1007/BF01986402
   Bijlsma JWJ, 2011, LANCET, V377, P2115, DOI 10.1016/S0140-6736(11)60243-2
   Bowden J, 2011, BMC MED RES METHODOL, V11, DOI 10.1186/1471-2288-11-41
   Cai LX., 2022, Chin Sci Technol J Database Med Health, V12), P0001
   Chen AF, 2020, BMC MUSCULOSKEL DIS, V21, DOI 10.1186/s12891-020-03380-5
   Chen G, 2018, NEURON, V100, P1292, DOI 10.1016/j.neuron.2018.11.009
   Chu JB, 2022, KNEE SURG SPORT TR A, V30, P4063, DOI 10.1007/s00167-022-06887-7
   Cole BJ, 2017, AM J SPORT MED, V45, P339, DOI 10.1177/0363546516665809
   Culvenor AG, 2017, ARTHRIT CARE RES, V69, P649, DOI 10.1002/acr.23005
   Dainese P, 2022, OSTEOARTHR CARTILAGE, V30, P516, DOI 10.1016/j.joca.2021.12.003
   Dantas LO, 2021, BRAZ J PHYS THER, V25, P688, DOI 10.1016/j.bjpt.2021.07.003
   Dogan N, 2022, JCPSP-J COLL PHYSICI, V32, P1441, DOI 10.29271/jcpsp.2022.11.1441
   Donec V, 2020, CLIN REHABIL, V34, P877, DOI 10.1177/0269215520916859
   Dong B., 2022, Modern Chin Med, V42, P108, DOI [10.13424/j.cnki.mtcm.2022.01.021, DOI 10.13424/J.CNKI.MTCM.2022.01.021]
   Duymus TM, 2017, KNEE SURG SPORT TR A, V25, P485, DOI 10.1007/s00167-016-4110-5
   El-Hakeim EH, 2018, PAIN PHYSICIAN, V21, P169, DOI 10.36076/ppj.2018.2.169
   Elawamy A, 2021, PAIN PHYSICIAN, V24, P127, DOI 10.36076/ppj.2021.24.127-134
   Fang GG., 2022, J modern traditional Chin Med, V02), P122
   Feng WH., 2019, Sichuan J Physiol Sci, V44, P457
   Ferreira RM, 2019, ACTA REUMATOL PORT, V44, P173
   Görmeli G, 2017, KNEE SURG SPORT TR A, V25, P958, DOI 10.1007/s00167-015-3705-6
   Güler T, 2022, RHEUMATOL INT, V42, P591, DOI 10.1007/s00296-022-05101-8
   Günaydin OE, 2022, PHYSIOTHER THEOR PR, V38, P661, DOI 10.1080/09593985.2020.1780657
   Hei G., 2019, Chin J Pain Med, V26, P150
   Helianthi DR, 2016, ACTA MED INDONES, V48, P114
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928
   Huang XH., 2022, Chin J Clin Pharmacol, V12), P1316, DOI [10.13699/j.carolcarrollnki.1001-6821.2022.12.005, DOI 10.13699/J.CAROLCARROLLNKI.1001-6821.2022.12.005]
   Hussain SM, 2016, SCOT MED J, V61, P7, DOI 10.1177/0036933015619588
   Hutton B, 2015, ANN INTERN MED, V162, P777, DOI 10.7326/M14-2385
   Ji JJ., 2020, Chin J geriatric multi-organ Dis, V20, P410
   Jiang F., 2018, Chin J Modern Med, V28, P48
   Ju ZY., 2017, J SHANGHAI ACUPUNCTU, V4, P1111, DOI DOI 10.13460/JISSN.1005-0957.2017.09.1111
   Kolasinski SL, 2020, ARTHRITIS RHEUMATOL, V72, P220, DOI [10.1002/art.41142, 10.1002/acr.24131]
   Kong LL., 2020, Jiangsu Med, V46-48, P1000, DOI [10.19460/j.carolcarrollnki.0253-3685.2020.10.008, DOI 10.19460/J.CAROLCARROLLNKI.0253-3685.2020.10.008]
   Levinger I, 2011, ARTHRITIS RHEUM-US, V63, P1343, DOI 10.1002/art.30287
   Li HT., 2017, J traditional Chin Med, V01), P110, DOI [10.19664/j.carolcarrollnki.1002-2392.2017.01.033, DOI 10.19664/J.CAROLCARROLLNKI.1002-2392.2017.01.033]
   Li JF., 2018, Chin elderly Med J, V10), P1126, DOI [10.3760/cma.J.iSSN.0254-9026.2018.10.016, DOI 10.3760/CMA.J.ISSN.0254-9026.2018.10.016]
   Li MX., 2019, J TRADITIONAL CHINES, V35, P35
   Li SM, 2021, TRIALS, V22, DOI 10.1186/s13063-021-05786-5
   Li WW., 2021, Med J Chin People's Health, V9, P0005
   Li YJ., 2002, Lab Med Clinic, V19, P240
   [李忠龙 Li Zhonglong], 2015, [中国康复医学杂志, Chinese Journal of Rehabilitation Medicine], V30, P580
   Lin L., 2021, Shanghai Univ traditional Chin Med, DOI [10.27320/,dcnki.Gszyu.2019.000043, DOI 10.27320/,DCNKI.GSZYU.2019.000043]
   Lin X., 2018, J Chin Med, V4, P23, DOI [10.13193/j.iSSN.1673-7717.2018.01.005, DOI 10.13193/J.ISSN.1673-7717.2018.01.005]
   Liu WF., 2019, China Med Equip Inf, V25, P61
   Liu Y, 2022, WORLD J ACUPUNCT-MOX, V32, P329, DOI 10.1016/j.wjam.2022.07.009
   de Jesus CCL, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0179185
   Lv ZT, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1899-6
   Ma JY., 2017, Hainan Med, V28, P3553
   Mabey T, 2016, BIOMARKERS, V21, P639, DOI 10.3109/1354750X.2016.1171907
   Meng F, 2017, Hebei Med, V39, P168
   Meng T., 2018, Chongqing Med J, V47, P3184
   Moffett John, 2012, J Pain Res, V5, P347, DOI 10.2147/JPR.S35076
   Mostafa MSEM, 2022, PHOTOBIOMOD PHOTOMED, V40, P198, DOI 10.1089/photob.2021.0136
   Mutlu EK, 2017, AM J PHYS MED REHAB, V96, P25, DOI 10.1097/PHM.0000000000000520
   Page MJ, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-019703
   Pan JK., 2023, TRADITIONAL CHINESE, V35, P1
   Pan Q., 2023, J Liaoning Tradit Chin Med, V50, P174, DOI 10.13192/j.iSSN.1000-1719.2023.03.049
   Park YB, 2021, AM J SPORT MED, V49, P487, DOI 10.1177/0363546520986867
   Patel S, 2013, AM J SPORT MED, V41, P356, DOI 10.1177/0363546512471299
   Perlman A, 2019, J GEN INTERN MED, V34, P379, DOI 10.1007/s11606-018-4763-5
   Raeissadat SA, 2021, BMC MUSCULOSKEL DIS, V22, DOI 10.1186/s12891-021-04017-x
   Rahimzadeh Poupak, 2022, Anesth Pain Med, V12, pe127121, DOI [10.5812/aapm-127121, 10.5812/aapm-127121]
   Reyes-Sosa R, 2020, J APPL BIOMED, V18, P41, DOI 10.32725/jab.2020.012
   Rouse B, 2017, INTERN EMERG MED, V12, P103, DOI 10.1007/s11739-016-1583-7
   Sari Z, 2019, PAIN RES MANAG, V2019, DOI 10.1155/2019/8514808
   Seitidis G, 2022, PREV SCI, V23, P415, DOI 10.1007/s11121-021-01289-6
   Shen XY, 2009, LASER MED SCI, V24, P129, DOI 10.1007/s10103-007-0536-9
   Shi BH., 2019, Clin Rev, V35, P1111
   Shim S, 2017, EPIDEMIOL HEALTH, V39, DOI 10.4178/epih.e2017047
   Sluijter Menno E, 2008, Pain Pract, V8, P57, DOI 10.1111/j.1533-2500.2007.00172.x
   Su Wenzhen, 2019, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V33, P1527, DOI 10.7507/1002-1892.201905007
   Tu JF, 2021, ARTHRITIS RHEUMATOL, V73, P448, DOI 10.1002/art.41584
   Uematsu H, 2021, PAIN PHYSICIAN, V24, pE761, DOI 10.36076/ppj.2021.24.e761
   Uhlmann L, 2018, BMC MED RES METHODOL, V18, DOI 10.1186/s12874-018-0574-y
   Uysal A, 2020, INT ORTHOP, V44, P1311, DOI 10.1007/s00264-020-04541-w
   Vina ER, 2018, CURR OPIN RHEUMATOL, V30, P160, DOI 10.1097/BOR.0000000000000479
   Wang C., 2019, CHINESE J BONE INJUR, V35, P848
   Wang HL., 2019, J CLIN MEDICAL LIT E, V7, P74
   Wang Q., 2022, J Shanghai acupuncture magazine, V9, P713, DOI [10.13460/j.iSSN.1005-0957.2021.13.0048, DOI 10.13460/J.ISSN.1005-0957.2021.13.0048]
   Wang SQ., 2020, J Rehabilitation, V30, P177
   Wang XB., 2020, J TRADITIONAL CHINES, V13, P55, DOI DOI 10.19664/J.CAROLCARROLLNKI.1002-2392.200145
   Wang XC., 2016, Chin J Pain Med, V27, P785
   Wang YC, 2022, MEDICINA-LITHUANIA, V58, DOI 10.3390/medicina58081028
   Wang Z, 2023, EUR J MED RES, V28, DOI 10.1186/s40001-022-00968-6
   Watt Jennifer, 2022, Methods Mol Biol, V2345, P187, DOI 10.1007/978-1-0716-1566-9_12
   Wu MX, 2010, CHIN J INTEGR MED, V16, P291, DOI 10.1007/s11655-010-0513-1
   Wu YL., 2022, Clin J Pract Hospital, V19, P62, DOI [10.3969/j.issn.1672-6170.2022.02.017, DOI 10.3969/J.ISSN.1672-6170.2022.02.017]
   Xie JW, 2021, AGEING RES REV, V70, DOI 10.1016/j.arr.2021.101413
   Xin R., 2021, J Clin Med Res Pract, V6, P35, DOI [10.19347/j.carolcarrollnki.2096-1413.202109013, DOI 10.19347/J.CAROLCARROLLNKI.2096-1413.202109013]
   Xiong YZ., 2020, CHINESE J ORTHOPAEDI, V28, P19
   Xu Dang-Han, 2022, Zhongguo Zhen Jiu, V42, P1351, DOI 10.13703/j.0255-2930.20220126-k0002
   Xu H., 2023, WORLD CHIN MED, V18, P929
   Xu H, 2023, PAIN MED, V24, P244, DOI 10.1093/pm/pnac127
   Yang S., 2022, CHINESE J ACUTE CHIN, V31, P1177
   Yu SP, 2015, AUST PRESCR, V38, P115, DOI 10.18773/austprescr.2015.039
   Yurtkuran M, 2007, PHOTOMED LASER SURG, V25, P14, DOI 10.1089/pho.2006.1093
   Zhang W, 2008, OSTEOARTHR CARTILAGE, V16, P137, DOI 10.1016/j.joca.2007.12.013
   Zhang WJ., 2020, West J Trad Chin Med, V33, P107, DOI 10.12174/j.issn.1004-6852.2020.09.31
   Zhao L, 2021, J RHEUMATOL, V48, P924, DOI 10.3899/jrheum.200217
   Zhao Q., 2021, J Logistics Coll Armed Police Force (Medical Edition), V30, P20, DOI [10.16548/J.2095-3720.2021.11.072, DOI 10.16548/J.2095-3720.2021.11.072]
   Zhao Z, 2013, J SURG RES, V185, P661, DOI 10.1016/j.jss.2013.07.004
   Zheng LL., 2019, J Tissue Eng, V27, P5681
   Zheng YL., 2011, Chin J Clin, V49, P717
   Zhong ZY, 2019, ARCH PHYS MED REHAB, V100, P1695, DOI 10.1016/j.apmr.2019.04.020
   Zhu DY., 2019, Fujian Univ Traditional Chin Med
   Zhuo ZM., 2021, Modern Biomed Prog, V21, P2551
   Zuo XT., 2022, Nanjing Univ Chin Med, DOI [10.27253/dcnki.Gnjzu.2021.000208, DOI 10.27253/DCNKI.GNJZU.2021.000208]
NR 120
TC 20
Z9 22
U1 8
U2 38
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD DEC 14
PY 2023
VL 14
AR 1309751
DI 10.3389/fimmu.2023.1309751
PG 20
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA DP1H5
UT WOS:001133163400001
PM 38155966
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, D
   Shi, HS
   Yang, ZG
   Liu, WB
   Qi, L
   Dong, CD
   Si, GM
   Guo, Q
AF Wang, Dan
   Shi, Hongshuo
   Yang, Zhenguo
   Liu, Wenbin
   Qi, Lu
   Dong, Chengda
   Si, Guomin
   Guo, Qi
TI Efficacy and Safety of Transcutaneous Electrical Acupoint Stimulation
   for Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials
SO PAIN RESEARCH & MANAGEMENT
LA English
DT Review
ID SURGERY; ACUPUNCTURE; ELECTROACUPUNCTURE; CANCER; ANALGESICS;
   ANESTHESIA; MANAGEMENT; RECOVERY; QUALITY
AB Objective. This meta-analysis aims to evaluate the effectiveness and safety of transcutaneous electrical acupoint stimulation (TEAS) in treating post-operative pain. Methods. This meta-analysis was registered in PROSPERO (CRD42021286753). We searched PubMed, Embase, and the Cochrane Library for relevant randomized controlled trials (RCTs) about TEAS in treating postoperative pain that were published before November 2021. The primary outcome was visual analogue scale (VAS) within 24 h after surgery. The secondary outcomes included postoperative opioid analgesic drug consumption and the occurrence of adverse reactions within the postoperative 24-72 h. Adverse reactions included dizziness, nausea, and vomiting. Continuous variables were analyzed using mean difference (MDs) or standardized mean difference (SMDs) and 95% CIs. Relative risk (RR) and 95% CI were used for dichotomous data. The data were pooled and analyzed by RevMan 5.4 and STATA15.0 software. Results. Seventeen trials with 1375 participants were included. The current results suggested that application of TEAS showed obvious superiority in reducing VAS scores (SMD = -1.51, 95% CI = -2.20 similar to-0.82, I2 = 96%). Subgroup analysis was performed according to open surgery and minimally invasive surgery. VAS scores were decreased after surgery at 24 h (SMD = -0.84, 95% CI = -1.07 similar to-0.6, I2 = 96%; SMD = -0.88, 95% CI = -1.02 similar to-0.75, I2 = 96%). The incidence of postoperative dizziness and nausea and vomiting was significantly lower in the TEAS group within postoperative 24-72 h (RR = 0.48, 95% CI = 0.34 similar to 0.68, I2 = 0%; RR = 0.66, 95% CI = 0.44 similar to 1.01, I2 = 69%; and RR = 0.49, 95% CI = 0.24 similar to 1.00, I2 = 51%). Postoperative opioid analgesics were also reduced in the TEAS group within 72 h after surgery (SMD = -2.10, 95% CI = -3.37 similar to-0.82, I2 = 96%). Conclusions. TEAS can reduce postoperative pain as well as the incidence of dizziness, nausea, and vomiting and the number of analgesics used after surgery. TEAS is a reasonable modality to incorporate into a multimodal management approach for postoperative pain.
C1 [Wang, Dan; Shi, Hongshuo] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan, Peoples R China.
   [Yang, Zhenguo; Liu, Wenbin; Qi, Lu] Shandong Univ Tradit Chinese Med, Affiliated Hosp 2, Jinan, Peoples R China.
   [Dong, Chengda] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Peoples R China.
   [Si, Guomin] Shandong First Med Univ, Dept Tradit Chinese Med, Prov Hosp, Jinan, Peoples R China.
   [Guo, Qi] 960 Hosp PLA, Dept Aviat Dis, Jinan, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University of Traditional
   Chinese Medicine; Shandong First Medical University & Shandong Academy
   of Medical Sciences
RP Guo, Q (corresponding author), 960 Hosp PLA, Dept Aviat Dis, Jinan, Peoples R China.
EM wd19961007@163.com; zc141319@yeah.net; yangzhenguo81@163.com;
   7214933@qq.com; ql_fox@126.com; 15066132023@163.com; sgm977tc@163.com;
   nationalflag@qq.com
RI ; Qi, Luke/MJK-0172-2025
OI Guo, Qi/0000-0001-7542-9539; 
CR Ao L, 2021, EXP THER MED, V21, DOI 10.3892/etm.2021.9615
   Becker Daniel E, 2012, Anesth Prog, V59, P90, DOI 10.2344/0003-3006-59.2.90
   Bicket MC, 2017, JAMA SURG, V152, P1066, DOI 10.1001/jamasurg.2017.0831
   Cai M, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1665-3
   Chang Peng-Yuan, 2016, Neurosurgery, V63 Suppl 1, P43, DOI [10.1227/neu.0000000000001296, 10.1227/NEU.0000000000001296]
   Chen JB, 2020, INT J SURG, V73, P57, DOI 10.1016/j.ijsu.2019.10.036
   Chen JH, 2020, THORAC CANCER, V11, P928, DOI 10.1111/1759-7714.13343
   de Souza RC, 2016, LASER MED SCI, V31, P1645, DOI 10.1007/s10103-016-2032-6
   Gong YN, 2020, J LEUKOCYTE BIOL, V108, P189, DOI 10.1002/JLB.3AB0420-361RR
   Hemmings HC, 2019, BRIT J ANAESTH, V122, P705, DOI 10.1016/j.bja.2019.04.003
   Juruena MF, 2020, ADV EXP MED BIOL, V1191, P141, DOI 10.1007/978-981-32-9705-0_9
   Kehlet H, 2006, LANCET, V367, P1618, DOI 10.1016/S0140-6736(06)68700-X
   Li MM, 2020, NEUROMODULATION, V23, P838, DOI 10.1111/ner.13178
   Lin YW, 2020, BRAIN BEHAV IMMUN, V89, P604, DOI 10.1016/j.bbi.2020.06.033
   Liu X, 2015, ACUPUNCT MED, V33, P270, DOI 10.1136/acupmed-2014-010749
   Lovich-Sapola J, 2015, SURG CLIN N AM, V95, P301, DOI 10.1016/j.suc.2014.10.002
   McNicol E, 2003, J PAIN, V4, P231, DOI 10.1016/S1526-5900(03)00556-X
   Qu F, 2015, INT J CLIN EXP MED, V8, P7754
   Raja SN, 2020, PAIN, V161, P1976, DOI 10.1097/j.pain.0000000000001939
   Rawal N, 2016, EUR J ANAESTH, V33, P160, DOI 10.1097/EJA.0000000000000366
   Schjerning AM, 2020, NAT REV CARDIOL, V17, P574, DOI 10.1038/s41569-020-0366-z
   Sharififar S, 2018, ANN PHYS REHABIL MED, V61, P339, DOI 10.1016/j.rehab.2018.06.005
   Shinbara H, 2015, ACUPUNCT MED, V33, P65, DOI 10.1136/acupmed-2014-010634
   Song BJ, 2020, NAT SCI SLEEP, V12, P809, DOI 10.2147/NSS.S270739
   Sun K, 2017, CLIN J PAIN, V33, P340, DOI 10.1097/AJP.0000000000000400
   Szmit M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10010146
   Tai JB, 2020, ANN PALLIAT MED, V9, P2538, DOI 10.21037/apm-19-434
   Tanaka M, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9080897
   Tu Q, 2019, UROLITHIASIS, V47, P279, DOI 10.1007/s00240-018-1056-8
   Ulett GA, 1998, BIOL PSYCHIAT, V44, P129, DOI 10.1016/S0006-3223(97)00394-6
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Wang BG, 1997, ANESTH ANALG, V85, P406, DOI 10.1097/00000539-199708000-00029
   Wang LL, 2020, LIFE SCI, V261, DOI 10.1016/j.lfs.2020.118473
   Wang Y, 2005, EXP NEUROL, V192, P156, DOI 10.1016/j.expneurol.2004.11.003
   Wick EC, 2017, JAMA SURG, V152, P691, DOI 10.1001/jamasurg.2017.0898
   Yao YS, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/324360
   Yeh ML, 2018, CLIN NURS RES, V27, P450, DOI 10.1177/1054773816685745
   Yeh ML, 2011, INT J NURS STUD, V48, P703, DOI 10.1016/j.ijnurstu.2010.10.009
   Yu XD, 2020, TRIALS, V21, DOI 10.1186/s13063-019-3892-4
   Zhan WF, 2020, EUR J INTEGR MED, V35, DOI 10.1016/j.eujim.2020.101087
   Zhang Q, 2014, ANAESTHESIA, V69, P832, DOI 10.1111/anae.12639
   Zhang Y, 2013, MAGN RESON IMAGING, V31, P1105, DOI 10.1016/j.mri.2013.01.006
   Zhao YX, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/627023
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zhou X, 2021, CANCER MANAG RES, V13, P1449, DOI 10.2147/CMAR.S292325
   Zhuang Y, 2013, INT REV NEUROBIOL, V111, P1, DOI 10.1016/B978-0-12-411545-3.00001-8
NR 46
TC 43
Z9 51
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1203-6765
EI 1918-1523
J9 PAIN RES MANAG
JI Pain Res. Manag.
PD APR 14
PY 2022
VL 2022
AR 7570533
DI 10.1155/2022/7570533
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 1V6FZ
UT WOS:000806184400003
PM 35463630
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Oh, PJ
   Kim, YL
AF Oh, Pok-Ja
   Kim, You Lim
TI Effectiveness of Non-Pharmacologic Interventions in Chemotherapy Induced
   Peripheral Neuropathy: A Systematic Review and Meta-Analysis
SO JOURNAL OF KOREAN ACADEMY OF NURSING
LA Korean
DT Review
DE Chemotherapy; Adjuvant; Meta-analysis; Peripheral Nervous System
   Diseases
ID COLORECTAL-CANCER SURVIVORS; QUALITY-OF-LIFE; ACUPUNCTURE; MANAGEMENT;
   STRENGTH; BALANCE; OXALIPLATIN; THERAPY; TRIAL
AB Purpose: This study was conducted to evaluate the effectiveness of non-pharmacologic interventions in chemotherapy-induced peripheral neuropathy (CIPN). Methods: PubMed, Cochrane Library CENTRAL, EMBASE, CINAHL, and several Korean databases (Until August 2017) were searched. The main search strategy combined terms for peripheral neuropathy and presence of neoplasms. The risk of bias was assessed using the Cochrane's Risk of Bias tool for randomized studies and the Risk of Bias Assessment tool for non-randomized studies. To estimate the effect size, a meta-analysis of the studies was performed using the Rev Man 5.3 program of the Cochrane Library random-effects models were used in the analyses. Results: Twenty-two studies with a total of 954 participants met the inclusion criteria. Of the 22 studies, 12 were used to estimate the effect size of the non-pharmacologic interventions. The non-pharmacologic interventions used in patients with CIPN were exercise, acupuncture, massage, and foot bath. The acupuncture significantly reduced CIPN symptoms and signs (d=-0.71) and CIPN pain (d=0.73) (p<.001). Massage and foot bath were also effective in reducing CIPN symptoms (d=-0.68; 950/0 Cl=-1.05,-0.30; p<.001; l(2)=19%).Exercises were effective in improving muscle strength and endurance(d=-0.55) and quality of life (d=-2.96), but they were not significantly effective in improving CIPN. Conclusion: Although these results provide little evidence of the effectiveness of acupuncture, massage, and foot bath in the treatment of CIPN, they suggest that these interventions can reduce CIPN symptoms in patients with cancer. However, the findings of this study should be interpreted with caution as there is a relative lack of data in this field, and additional well-designed studies are needed.
C1 [Oh, Pok-Ja] Sahmyook Univ, Dept Nursing, Seoul, South Korea.
   [Kim, You Lim] Sahmyook Univ, Dept Phys Therapy, Lab Rehabil & Hlth Sci, 815 Hwarang Ro, Seoul 01795, South Korea.
C3 Sahmyook University; Sahmyook University
RP Kim, YL (corresponding author), Sahmyook Univ, Dept Phys Therapy, Lab Rehabil & Hlth Sci, 815 Hwarang Ro, Seoul 01795, South Korea.
EM youlimy81@naver.com
OI Oh, Pok-Ja/0000-0002-5963-5516; Kim, You Lim/0000-0003-0610-2465
FU National Research Foundation of Korea (NRF) - Korea government (MSIT)
   [NRF-2017RIA2B1002950]
FX This research was supported by the National Research Foundation of Korea
   (NRF) funded by the Korea government (MSIT) (No. NRF-2017RIA2B1002950).
CR [Anonymous], COCHRANE HDB SYSTEMA
   Argyriou AA, 2011, J PAIN SYMPTOM MANAG, V41, P126, DOI 10.1016/j.jpainsymman.2010.04.021
   Balducci S, 2006, J DIABETES COMPLICAT, V20, P216, DOI 10.1016/j.jdiacomp.2005.07.005
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Brami C, 2016, CRIT REV ONCOL HEMAT, V98, P325, DOI 10.1016/j.critrevonc.2015.11.014
   Chang-Han woo, 2014, [Journal of Physiology & Pathology in Korean Medicine, 동의생리병리학회지], V28, P460
   Cramp F, 2010, SUPPORT CARE CANCER, V18, P1367, DOI 10.1007/s00520-010-0904-z
   Cunningham JE, 2011, SUPPORT CARE CANCER, V19, P1473, DOI 10.1007/s00520-011-1231-8
   Derksen TME, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/7916031
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Falconer J, 1990, Arthritis Care Res, V3, P85, DOI 10.1002/art.1790030206
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Gutiérrez-Gutiérrez G, 2010, CLIN TRANSL ONCOL, V12, P81, DOI 10.1007/S12094-010-0474-z
   Henke CC, 2014, SUPPORT CARE CANCER, V22, P95, DOI 10.1007/s00520-013-1925-1
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Kim IY, 2011, KOREAN J CLIN ONCOL, V7, P11
   Kim S. E., 2017, THESIS SEOUL NATL U, P1
   Kim SY, 2013, J CLIN EPIDEMIOL, V66, P408, DOI 10.1016/j.jclinepi.2012.09.016
   Kwak MK, 2010, J KOREAN ONCOL NURS, V10, P231, DOI DOI 10.5388/JK0N.2010.10.2.231
   Lee JP, 2014, J MECH SCI TECHNOL, V28, P565, DOI 10.1007/s12206-013-1123-6
   Lee SY, 2012, ASIAN ONCOL NURS, V12, P305
   LINDEMAN E, 1995, ARCH PHYS MED REHAB, V76, P612, DOI 10.1016/S0003-9993(95)80629-6
   Litscher G, 2002, LASER MED SCI, V17, P19, DOI 10.1007/s10103-002-8262-9
   Ma SX, 2000, BRAIN RES, V855, P124, DOI 10.1016/S0006-8993(99)02379-3
   McRee Laura D, 2003, AORN J, V78, P433, DOI 10.1016/S0001-2092(06)60754-0
   Melzack R, 1996, PAIN FORUM, V5, P128
   Mols F, 2015, J CANCER SURVIV, V9, P512, DOI 10.1007/s11764-015-0427-1
   Noh GO, 2017, THESIS, P1
   Ogawa K, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/928129
   Oh SS, 2002, META ANAL THEORY PRA, P185
   Park JW, 2015, ADV MATER SCI ENG, V2015, DOI 10.1155/2015/273101
   Richardson JK, 2001, ARCH PHYS MED REHAB, V82, P205, DOI 10.1053/apmr.2001.19742
   Rostock M, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/349653
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Schwenk M, 2016, GERONTOLOGY, V62, P553, DOI 10.1159/000442253
   Speck R, 2012, SUPPORT CARE CANCER, V20, P2433, DOI 10.1007/s00520-011-1365-8
   Streckmann F, 2014, ANN ONCOL, V25, P493, DOI 10.1093/annonc/mdt568
   Streckmann F, 2014, SPORTS MED, V44, P1289, DOI 10.1007/s40279-014-0207-5
   Stubblefield MD, 2009, J NATL COMPR CANC NE, V7, pS1, DOI 10.6004/jnccn.2009.0078
   Tofthagen C, 2014, REHABIL ONCOL, V32, P38, DOI 10.1097/01893697-201432040-00007
   Trivedi MS, 2015, AM J HEMATOL-ONCOL, V11, P4
   Valentine-Davis B, 2015, MED ACUPUNCT, V27, P216, DOI 10.1089/acu.2015.1103
   Wonders K.Y., 2014, Int. J. Phys. Med. Rehabil, V2, P210, DOI [10.4172/2329-9096.1000210, DOI 10.4172/2329-9096.1000210]
   Wonders KY, 2013, HEALTH PSYCHOL RES, V1, P149, DOI [10.4082/hpr.2013.e28, 10.4081/hpr.2013.e28]
   Wong Raimond, 2006, Acupunct Med, V24, P87
NR 45
TC 24
Z9 34
U1 2
U2 30
PU KOREAN SOC NURSING SCIENCE
PI SEOUL
PA KOREA SCIENCE & TECHNOL CTR, 635-4 YEOKSAM-DONG, KANGNAM-GU,, SEOUL,
   135-703, SOUTH KOREA
SN 2005-3673
EI 2093-758X
J9 J KOREAN ACAD NURS
JI J. Korean Acad. Nurs.
PD APR
PY 2018
VL 48
IS 2
BP 123
EP 142
DI 10.4040/jkan.2018.48.2.123
PG 20
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA GG1CF
UT WOS:000432416200001
PM 29735874
OA hybrid
DA 2026-01-16
ER

PT J
AU Sharon, H
   Goldway, N
   Goor-Aryeh, I
   Eisenberg, E
   Brill, S
AF Sharon, Haggai
   Goldway, Noam
   Goor-Aryeh, Itay
   Eisenberg, Elon
   Brill, Silviu
TI Personal experience and attitudes of pain medicine specialists in Israel
   regarding the medical use of cannabis for chronic pain
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE cannabis; pain; survey
ID CHRONIC NONCANCER PAIN; INHALED CANNABIS; MARIJUANA; PRESCRIPTION;
   MANAGEMENT; EFFICACY
AB Introduction: The scientific study of the role of cannabis in pain medicine still lags far behind the growing use driven by public approval. Accumulated clinical experience is therefore an important source of knowledge. However, no study to date has targeted physicians who actually use cannabis in their daily practice.
   Methods: Registered, active, board-certified pain specialists in Israel (n=79) were asked to complete a Web-based survey. The survey was developed using the Qualtrics Online Survey Software. Questions were formulated as multiple-choice questions, and these addressed three areas of interest: 1) doctors' personal experience; 2) the role of cannabis in pain medicine; and 3) cannabis medicalization and legalization.
   Results: Sixty-four percent of all practicing pain specialists in Israel responded. Almost all prescribe cannabis. Among them, 63% find cannabis moderately to highly effective, 56% have encountered mild or no side effects, and only 5% perceive it as significantly harmful. Common indications are neuropathic pain (65%), oncological pain (50%), arthralgias (25%), and any intractable pain (29%). Leading contraindications are schizophrenia (76%), pregnancy/breastfeeding (65%), and age <18 years (59%). Only 12% rated cannabis as more hazardous than opiates. On a personal note, 45% prefer cannabis for themselves or a family member. Lastly, 54% would like to see cannabis legalized in Israel.
   Conclusion: In this survey, pain clinicians experienced in prescribing cannabis over prolonged periods view it as an effective and relatively safe treatment for chronic pain, based on their own experience. Their responses suggest a possible change of paradigm from using cannabis as the last resort.
C1 [Sharon, Haggai; Brill, Silviu] Tel Aviv Sourasky Med Ctr, Inst Pain Med, Dept Anesthesiol & Crit Care Med, Tel Aviv, Israel.
   [Sharon, Haggai; Goldway, Noam] Tel Aviv Sourasky Med Ctr, Ctr Brain Funct, Wohl Inst Adv Imaging, Tel Aviv, Israel.
   [Sharon, Haggai] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
   [Sharon, Haggai] Guys & St Thomas Hosp, Pain Management & Neuromodulat Ctr, London, England.
   [Goor-Aryeh, Itay] Sheba Med Ctr, Pain Ctr, Tel Hashomer, Israel.
   [Eisenberg, Elon] Inst Pain Med, Rambam Hlth Care Campus, Haifa, Israel.
   [Eisenberg, Elon] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
   [Brill, Silviu] Ben Gurion Univ Negev, Fac Hlth Sci, Goldman Sch Med, Beer Sheva, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv Sourasky Medical Center; Tel Aviv University; Sackler Faculty of
   Medicine; Guy's & St Thomas' NHS Foundation Trust; Chaim Sheba Medical
   Center; Tel Aviv University; Rambam Health Care Campus; Technion Israel
   Institute of Technology; Rappaport Faculty of Medicine; Ben-Gurion
   University of the Negev
RP Sharon, H (corresponding author), Tel Aviv Sourasky Med Ctr, Inst Pain Med, Dept Anesthesia & Crit Care Med, 6 Weitzman St, IL-64239 Tel Aviv, Israel.
EM haggais@tasmc.gov.il
OI Sharon, Haggai/0000-0003-1981-658X; brill, silviu/0000-0001-7150-5821;
   Goldway, Noam/0000-0001-8816-5667
CR Ablin JN, 2016, RAMBAM MAIMONIDES ME, V7, DOI 10.5041/RMMJ.10239
   Abrams DI, 2007, NEUROLOGY, V68, P515, DOI 10.1212/01.wnl.0000253187.66183.9c
   Andreae MH, 2015, J PAIN, V16, P1221, DOI 10.1016/j.jpain.2015.07.009
   [Anonymous], 2010, CAN MED ASSOC J, DOI DOI 10.1503/cmaj.091414
   [Anonymous], INT J METHODS PSYCHI
   Barrie N, 2017, INT J RHEUM DIS, V20, P789, DOI 10.1111/1756-185X.13146
   Blake A, 2017, ANN PALLIAT MED, V6, pS215, DOI 10.21037/apm.2017.08.05
   Blake DR, 2006, RHEUMATOLOGY, V45, P50, DOI 10.1093/rheumatology/kei183
   Bostwick JM, 2012, MAYO CLIN PROC, V87, P172, DOI 10.1016/j.mayocp.2011.10.003
   Charuvastra A, 2005, J ADDICT DIS, V24, P87, DOI 10.1300/J069v24n03_07
   Chou R, 2016, J PAIN, V17, P131, DOI 10.1016/j.jpain.2015.12.008
   Crowley D, 2017, HARM REDUCT J, V14, DOI 10.1186/s12954-016-0129-7
   Curran HV, 2016, NAT REV NEUROSCI, V17, P293, DOI 10.1038/nrn.2016.28
   DOBLIN RE, 1991, J CLIN ONCOL, V9, P1314, DOI 10.1200/JCO.1991.9.7.1314
   Ebert T, 2015, ISR MED ASSOC J, V17, P437
   Feingold D, 2017, PAIN MED, V18, P294, DOI 10.1093/pm/pnw134
   Franz CA, 2016, CARDIOL REV, V24, P158, DOI 10.1097/CRD.0000000000000103
   Garry A, 2009, J TOXICOL-US, V2009, DOI 10.1155/2009/596149
   Goyal H, 2017, J THORAC DIS, V9, P2079, DOI 10.21037/jtd.2017.06.104
   Goyal H, 2017, EUR J GASTROEN HEPAT, V29, P135, DOI 10.1097/MEG.0000000000000779
   Hadland SE, 2015, J DEV BEHAV PEDIATR, V36, P115, DOI 10.1097/DBP.0000000000000129
   Häuser W, 2018, EUR J PAIN, V22, P455, DOI 10.1002/ejp.1118
   Häuser W, 2017, DTSCH ARZTEBL INT, V114, P627, DOI 10.3238/arztebl.2017.0627
   Hill KP, 2015, JAMA-J AM MED ASSOC, V313, P2474, DOI 10.1001/jama.2015.6199
   Kim PS, 2017, CURR PAIN HEADACHE R, V21, DOI 10.1007/s11916-017-0619-7
   Kondrad E, 2013, J AM BOARD FAM MED, V26, P52, DOI 10.3122/jabfm.2013.01.120089
   Lopez-Quintero C, 2011, DRUG ALCOHOL DEPEN, V115, P120, DOI 10.1016/j.drugalcdep.2010.11.004
   Lynch ME, 2015, J NEUROIMMUNE PHARM, V10, P293, DOI 10.1007/s11481-015-9600-6
   Lynch ME, 2011, BRIT J CLIN PHARMACO, V72, P735, DOI 10.1111/j.1365-2125.2011.03970.x
   Manrique-Garcia E, 2014, PSYCHOL MED, V44, P2513, DOI 10.1017/S0033291714000191
   National Institute for Health and Care Excellence, 2016, Clinical Guidelines. Low back pain and sciatica in over 16s: assessment and management
   Romero-Sandoval EA, 2017, CURR RHEUMATOL REP, V19, DOI 10.1007/s11926-017-0693-1
   Schwartz RH, 1997, SOUTH MED J, V90, P167, DOI 10.1097/00007611-199702000-00001
   Thomas G, 2014, AM J CARDIOL, V113, P187, DOI 10.1016/j.amjcard.2013.09.042
   van der Pol P, 2013, DRUG ALCOHOL DEPEN, V133, P352, DOI 10.1016/j.drugalcdep.2013.06.009
   Wallace MS, 2015, J PAIN, V16, P616, DOI 10.1016/j.jpain.2015.03.008
   Whiting PF, 2015, JAMA-J AM MED ASSOC, V313, P2456, DOI 10.1001/jama.2015.6358
   Ziemianski D, 2015, BMC MED EDUC, V15, DOI 10.1186/s12909-015-0335-0
NR 38
TC 27
Z9 33
U1 0
U2 13
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2018
VL 11
BP 1411
EP 1419
DI 10.2147/JPR.S159852
PG 9
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA GO8BQ
UT WOS:000440308500003
PM 30104896
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Shenouda, M
   Copley, R
   Pacioles, T
   Lebowicz, Y
   Jamil, M
   Akpanudo, S
   Tirona, MT
AF Shenouda, Mina
   Copley, Renee
   Pacioles, Toni
   Lebowicz, Yehuda
   Jamil, Muhammad
   Akpanudo, Sutoidem
   Tirona, Maria Tria
TI Effect of Tart Cherry on Aromatase Inhibitor-Induced Arthralgia (AIA) in
   Nonmetastatic Hormone-Positive Breast Cancer Patients: A Randomized
   Double-Blind Placebo-Controlled Trial
SO CLINICAL BREAST CANCER
LA English
DT Article
DE Aromatase inhibitor arthralgia; Aromatase inhibitor adherence;
   Musculoskeletal syndrome; Tart cherry; Pain
ID MUSCULOSKELETAL SYNDROME; JUICE BLEND; SYMPTOMS; PAIN; CONSUMPTION;
   WOMEN; RISK; ACUPUNCTURE; SURVIVORS; ESTROGEN
AB Aromatase Inhibitor induced Arthralgia (AIA) can cause noncompliance leading to decreased breast-cancer survival. Effective interventions for AIA are limited. Tart cherry (TC) showed beneficial effect on musculoskeletal pain. 48 patients (Pts) randomized to TC versus placebo over 6 weeks, TC (23pts) had 34.7% mean pain decrease versus 1.4% in Placebo (25pts). TC can improve AIA in non-metastatic breast-cancer patients.
   Background: Aromatase Inhibitor induced Arthralgia (AIA) can cause noncompliance leading to decreased breastcancer survival. Effective interventions for AIA are limited. Tart cherry (TC) showed beneficial effect on musculoskeletal pain. 48 patients (Pts) randomized to TC versus placebo over 6 weeks, TC (23pts) had 34.7% mean pain decrease versus 1.4% in Placebo (25pts). TC can improve AIA in nonmetastatic breast-cancer patients. Methods: Randomized, placebo-controlled, double-blind trial. Eligible patients with NMHPBC on AI for at least 4 weeks were randomized to TC concentrate [50 tart cherries] vs. placebo (P) [syrup] in 1:1 model. Patients instructed to consume 1 Oz of concentrate in 8 Oz water daily for 6 weeks, and document their pain intensity at baseline, weekly and at study completion in a diary using Visual Analog Scale (VAS), with 0 mm indicating no pain, and 100 mm indicating highest pain. Results: Sixty patients were enrolled. Two patients did not complete the study due to diarrhea, and 10 patients were noncompliant. Forty-eight patients were included in the final analysis. TC group (23 pts) had 34.7% mean decrease in pain compared to 1.4% in P group (25 pts). This difference was statistically significant (Mann-Whitney U Test, P =.034). Conclusions: Tart cherry can significantly improve AIA in nonmetastatic breast cancer patient. (C) 2021 The Authors. Published by Elsevier Inc.
C1 [Shenouda, Mina; Copley, Renee; Pacioles, Toni; Lebowicz, Yehuda; Jamil, Muhammad; Tirona, Maria Tria] Marshall Univ, Joan C Edwards Sch Med, Edwards Comprehens Canc Ctr, Hematol Oncol Dept, Huntington, WV 25701 USA.
   [Lebowicz, Yehuda] Univ Pittsburgh, Hillman Canc Ctr, Pittsburgh, PA USA.
   [Akpanudo, Sutoidem] Marshall Univ, Joan C Edwards Sch Med, Internal Med Dept, Huntington, WV 25701 USA.
   [Akpanudo, Sutoidem] Duke Univ, Internal Med Dept, Durham, NC USA.
C3 Marshall University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Marshall University; Duke
   University
RP Shenouda, M (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Hematol Oncol Dept, 1400 Hal Greer Blvd, Huntington, WV 25701 USA.
EM mshenouda11@gmail.com
OI Shenouda, Mina/0000-0002-0115-7646
FU Cherry Marketing Institute, Dewitt, Michigan; 2019 Conquer Cancer
   Foundation ASCO Merit Award
FX This work was supported by a grant from the Cherry Marketing Institute,
   Dewitt, Michigan. This study was granted the 2019 Conquer Cancer
   Foundation ASCO Merit Award.
CR Alba CMA, 2019, CRIT REV FOOD SCI, V59, P626, DOI 10.1080/10408398.2017.1384918
   Baglia ML, 2019, CANCER-AM CANCER SOC, V125, P2262, DOI 10.1002/cncr.32051
   Bauml J, 2015, BREAST CANCER RES, V17, DOI 10.1186/s13058-015-0599-7
   Bell PG, 2014, SCAND J MED SCI SPOR, V24, P477, DOI 10.1111/sms.12085
   Bell PG, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070441
   Bell PG, 2014, NUTRIENTS, V6, P829, DOI 10.3390/nu6020829
   Bijur PE, 2001, ACAD EMERG MED, V8, P1153, DOI 10.1111/j.1553-2712.2001.tb01132.x
   Bowtell JL, 2011, MED SCI SPORT EXER, V43, P1544, DOI 10.1249/MSS.0b013e31820e5adc
   Briot K, 2010, BREAST CANCER RES TR, V120, P127, DOI 10.1007/s10549-009-0692-7
   Chai SC, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020228
   Chirgwin JH, 2016, J CLIN ONCOL, V34, P2452, DOI 10.1200/JCO.2015.63.8619
   Coates AS, 2007, J CLIN ONCOL, V25, P486, DOI 10.1200/JCO.2006.08.8617
   Connolly DAJ, 2006, BRIT J SPORT MED, V40, P679, DOI 10.1136/bjsm.2005.025429
   Coombes RC, 2007, LANCET, V369, P559, DOI 10.1016/S0140-6736(07)60200-1
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Dimitriou L, 2015, J INT SOC SPORT NUTR, V12, DOI 10.1186/s12970-015-0085-8
   Dworkin RH, 2008, J PAIN, V9, P105, DOI 10.1016/j.jpain.2007.09.005
   Felson DT, 2005, ARTHRITIS RHEUM-US, V52, P2594, DOI 10.1002/art.21364
   Galantino ML, 2012, INTEGR CANCER THER, V11, P313, DOI 10.1177/1534735411413270
   Gallagher EJ, 2001, ANN EMERG MED, V38, P633, DOI 10.1067/mem.2001.118863
   Gupta A, 2020, JCO ONCOL PRACT, V16, P733, DOI 10.1200/OP.20.00113
   Halvorsen BL, 2006, AM J CLIN NUTR, V84, P95, DOI 10.1093/ajcn/84.1.95
   Henry NL, 2010, BRIT J CANCER, V103, P291, DOI 10.1038/sj.bjc.6605768
   Henry NL, 2018, J CLIN ONCOL, V36, P326, DOI 10.1200/JCO.2017.74.6651
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Howatson G, 2010, SCAND J MED SCI SPOR, V20, P843, DOI 10.1111/j.1600-0838.2009.01005.x
   Jacob RA, 2003, J NUTR, V133, P1826, DOI 10.1093/jn/133.6.1826
   Johnsen SP, 2005, ARCH INTERN MED, V165, P978, DOI 10.1001/archinte.165.9.978
   Kelley DS, 2006, J NUTR, V136, P981, DOI 10.1093/jn/136.4.981
   Kent K, 2017, EUR J NUTR, V56, P333, DOI 10.1007/s00394-015-1083-y
   Kim TH, 2018, MATURITAS, V118, P29, DOI 10.1016/j.maturitas.2018.09.005
   Kuehl KS, 2010, J INT SOC SPORT NUTR, V7, DOI 10.1186/1550-2783-7-17
   Lachin T, 2014, RECENT PATENTS ENDOC, V8, P67, DOI 10.2174/1872214808666140121151334
   Levers K, 2016, J INT SOC SPORT NUTR, V13, DOI 10.1186/s12970-016-0133-z
   Lintermans A, 2014, EUR J CANCER, V50, P2925, DOI 10.1016/j.ejca.2014.08.012
   Lombard JM, 2016, SUPPORT CARE CANCER, V24, P2139, DOI 10.1007/s00520-015-3001-5
   Magliano M, 2010, MATURITAS, V67, P29, DOI 10.1016/j.maturitas.2010.04.009
   Mao JJ, 2009, CANCER, V115, P3631, DOI 10.1002/cncr.24419
   McCormick R, 2016, J INT SOC SPORT NUTR, V13, DOI 10.1186/s12970-016-0151-x
   McCune LM, 2011, CRIT REV FOOD SCI, V51, P1, DOI 10.1080/10408390903001719
   Nahm Nicole, 2018, Asia Pac J Clin Oncol, V14, P374, DOI 10.1111/ajco.12845
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Ou BX, 2012, J FOOD SCI, V77, pH105, DOI 10.1111/j.1750-3841.2012.02681.x
   Pfeilschifter J, 2002, ENDOCR REV, V23, P90, DOI 10.1210/er.23.1.90
   Presant CA, 2007, CLIN BREAST CANCER, V7, P775, DOI 10.3816/CBC.2007.n.038
   Richette P, 2003, JOINT BONE SPINE, V70, P257, DOI 10.1016/S1297-319X(03)00067-8
   Santos RS, 2017, BIOL SEX DIFFER, V8, DOI 10.1186/s13293-017-0151-9
   Schumacher HR, 2013, OSTEOARTHR CARTILAGE, V21, P1035, DOI 10.1016/j.joca.2013.05.009
   Seeram NP, 2001, PHYTOMEDICINE, V8, P362, DOI 10.1078/0944-7113-00053
   Shen S, 2018, BREAST CANCER RES TR, V172, P603, DOI 10.1007/s10549-018-4946-0
   Tan AL, 2008, LANCET ONCOL, V9, P817, DOI 10.1016/S1470-2045(08)70217-1
   Vargas AJ, 2014, NUTR CANCER, V66, P1144, DOI 10.1080/01635581.2014.949801
   Zhang YQ, 2012, ARTHRITIS RHEUM-US, V64, P4004, DOI 10.1002/art.34677
NR 54
TC 7
Z9 8
U1 0
U2 5
PU CIG MEDIA GROUP, LP
PI DALLAS
PA 3500 MAPLE AVENUE, STE 750, DALLAS, TX 75219-3931 USA
SN 1526-8209
EI 1938-0666
J9 CLIN BREAST CANCER
JI Clin. Breast Cancer
PD JAN
PY 2022
VL 22
IS 1
BP E30
EP E36
DI 10.1016/j.clbc.2021.06.007
EA JAN 2022
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA YE1RO
UT WOS:000740907700008
PM 34275765
OA hybrid
DA 2026-01-16
ER

PT J
AU Collinge, W
   Kahn, J
   Walton, T
   Kozak, L
   Bauer-Wu, S
   Fletcher, K
   Yarnold, P
   Soltysik, R
AF Collinge, William
   Kahn, Janet
   Walton, Tracy
   Kozak, Leila
   Bauer-Wu, Susan
   Fletcher, Kenneth
   Yarnold, Paul
   Soltysik, Robert
TI Touch, Caring, and Cancer: randomized controlled trial of a multimedia
   caregiver education program
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Caregiver education; Oncology massage; Palliative care; Psychosocial
   oncology; Family caregivers
ID QUALITY-OF-LIFE; BREAST-CANCER; THERAPEUTIC MASSAGE; ADJUSTMENT;
   REFLEXOLOGY; MASTECTOMY; PAIN; NAUSEA; WOMEN
AB A randomized controlled trial was conducted to evaluate outcomes of a multimedia instructional program for family caregivers in simple touch-based techniques to provide comfort to cancer patients at home.
   A multilingual 78-min DVD and 66-page manual were produced for homebased instruction. Content addresses attitudes and communication about touch in cancer, psychological preparation for giving and receiving touch, safety precautions, massage techniques for comfort and relaxation, acupressure for specific cancer-related symptoms, and practice in the home setting. Materials were produced in English, Spanish, and Chinese versions. A community-based multiethnic sample of 97 adult patient/caregiver dyads was randomized to experimental (massage) or attention control (reading) groups for 4 weeks. Massage dyads received the program and instructions to practice at least three times per week, while control caregivers read to their patients for the same frequency. Self-report instruments assessed change in symptom severity, quality of life, perceived stress, and caregiver attitudes.
   Significant reductions in all symptoms occurred for patients after both activities: 12-28 % reductions after reading vs. 29-44 % after massage. Massage caregivers showed significant gains in confidence, comfort, and self-efficacy using touch and massage as forms of caregiving.
   Multimedia instruction in touch and massage methods may offer family members a viable means of enhancing self-efficacy and satisfaction in caregiving while decreasing patient pain, depression, and other symptoms. Family members may be able to learn and apply safe and simple methods that increase patient comfort and reduce distress.
C1 [Collinge, William] Collinge & Associates, Eugene, OR 97405 USA.
   [Kahn, Janet] Integrat Consulting, Burlington, VT 05401 USA.
   [Walton, Tracy] Tracy Walton & Associates LLC, Cambridge, MA 02140 USA.
   [Kozak, Leila] VA Puget Sound Hlth Care Syst HSR&D, VAPSHCS, Ctr Excellence Outcomes Res Older Adults, Seattle, WA USA.
   [Bauer-Wu, Susan] Emory Univ, Woodruff Sch Nursing, Atlanta, GA 30306 USA.
   [Fletcher, Kenneth] Univ Massachusetts, Sch Med, Dept Psychiat, Worcester, MA 01606 USA.
   [Yarnold, Paul] Optimal Data Anal LLC, San Diego, CA 92106 USA.
C3 Emory University; University of Massachusetts System; University of
   Massachusetts Worcester
RP Collinge, W (corresponding author), Collinge & Associates, 3986 N Shasta Loop, Eugene, OR 97405 USA.
EM william@collinge.org
RI ; Kozak, Leila/LZF-4618-2025
OI Yarnold, Paul/0000-0002-1648-739X; Kozak, Leila/0000-0002-5664-7140
FU Multimedia Technology Health Communication SBIR/STTR Grants; Health
   Communication Informatics Research Branch; Behavioral Research Program;
   Division of Cancer Control and Population Sciences, National Cancer
   Institute, National Institutes of Health, USA;  [R44CA103606-3]
FX This project was funded by grant No. R44CA103606-3, Multimedia
   Technology Health Communication SBIR/STTR Grants, Health Communication
   Informatics Research Branch, Behavioral Research Program, Division of
   Cancer Control and Population Sciences, National Cancer Institute,
   National Institutes of Health, USA.
CR [Anonymous], [No title captured], DOI DOI 10.1177/1049909108322292
   BAIDER L, 1988, ISRAEL J MED SCI, V24, P631
   BAIDER L, 1984, INT J PSYCHIAT MED, V14, P265, DOI 10.2190/WVVE-D9CF-VN7F-L4D7
   Billhult Annika, 2007, Clin Nurs Res, V16, P85, DOI 10.1177/1054773806298488
   Billhult A, 2007, J ALTERN COMPLEM MED, V13, P53, DOI 10.1089/acm.2006.6049
   Campeau Marie-Pierre, 2007, J Soc Integr Oncol, V5, P133, DOI 10.2310/7200.2007.018
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   CELLA DF, 1993, J CLIN ONCOL, V11, P570, DOI 10.1200/JCO.1993.11.3.570
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Collinge William, 2007, J Soc Integr Oncol, V5, P147, DOI 10.2310/7200.2007.013
   Demmer Craig, 2004, J Palliat Med, V7, P510, DOI 10.1089/1096621041838335
   Field TM, 1998, J APPL GERONTOL, V17, P229, DOI 10.1177/073346489801700210
   GIVEN CW, 1992, RES NURS HEALTH, V15, P271, DOI 10.1002/nur.4770150406
   Grealish L, 2000, CANCER NURS, V23, P237, DOI 10.1097/00002820-200006000-00012
   Keller M, 1998, PSYCHOTHER PSYCH MED, V48, P358
   Kirschner-Hermanns R, 2002, CRIT REV ONCOL HEMAT, V43, P141, DOI 10.1016/S1040-8428(02)00026-4
   Kutner JS, 2008, ANN INTERN MED, V149, P369, DOI 10.7326/0003-4819-149-6-200809160-00003
   Listing M, 2010, ARCH WOMEN MENT HLTH, V13, P165, DOI 10.1007/s00737-009-0143-9
   Listing M, 2009, PSYCHO-ONCOLOGY, V18, P1290, DOI 10.1002/pon.1508
   McCorkle R, 2001, Cancer Control, V8, P36
   Mehling WE, 2007, J PAIN SYMPTOM MANAG, V33, P258, DOI 10.1016/j.jpainsymman.2006.09.016
   Northouse LL, 2000, SOC SCI MED, V50, P271, DOI 10.1016/S0277-9536(99)00281-6
   OMNEPONTEN M, 1993, EUR J CANCER, V29A, P1393, DOI 10.1016/0959-8049(93)90009-5
   Post-White Janice, 2003, Integr Cancer Ther, V2, P332, DOI 10.1177/1534735403259064
   Poulin MJ, 2010, PSYCHOL AGING, V25, P108, DOI 10.1037/a0018064
   Ross CSK, 2002, PALLIATIVE MED, V16, P544, DOI 10.1191/0269216302pm597xx
   Sharp DM, 2010, EUR J CANCER, V46, P312, DOI 10.1016/j.ejca.2009.10.006
   Smith MC, 2002, J NURS SCHOLARSHIP, V34, P257, DOI 10.1111/j.1547-5069.2002.00257.x
   Stephenson N, 2003, APPL NURS RES, V16, P284, DOI 10.1016/j.apnr.2003.08.003
   Stephenson N L, 2000, Oncol Nurs Forum, V27, P67
   Stephenson NLN, 2007, ONCOL NURS FORUM, V34, P127, DOI 10.1188/07.ONF.127-132
   Stringer J, 2008, PSYCHO-ONCOL, V17, P1024, DOI 10.1002/pon.1331
   Sturgeon M, 2009, J ALTERN COMPLEM MED, V15, P373, DOI 10.1089/acm.2008.0399
   Weinrich S P, 1990, Appl Nurs Res, V3, P140, DOI 10.1016/S0897-1897(05)80135-1
   WELLISCH DK, 1978, AM J PSYCHIAT, V135, P543
   Wilkie D J, 2000, Hosp J, V15, P31
   Yarnold PR, 1997, STAT MED, V16, P1451, DOI 10.1002/(SICI)1097-0258(19970715)16:13<1451::AID-SIM571>3.0.CO;2-F
   YARNOLD PR, 2005, OPTIMAL DATA ANALYSI
NR 38
TC 47
Z9 60
U1 0
U2 48
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD MAY
PY 2013
VL 21
IS 5
BP 1405
EP 1414
DI 10.1007/s00520-012-1682-6
PG 10
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 117OK
UT WOS:000316962600025
PM 23262808
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Dogan, MD
AF Dogan, Melike Demir
TI The effect of reiki on pain: A meta-analysis
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Article
DE Reiki; Meta-analysis; Pain
ID NURSING INTERVENTION; THERAPY; ANXIETY; CANCER; MANAGEMENT; TRIAL;
   ACUPUNCTURE; ADULTS
AB Objective: Pain is one of the most common symptoms and may lead to important psychological, mental, and physiological problems in individuals. According to data by The Center for Reiki Research, Reiki is an effective approach to decrease the levels of pain, depression, and anxiety. Therefore, the aim of this meta-analysis was to investigate the effect of Reiki on pain level.
   Methods: Randomized controlled clinical trials in databases of Pubmed, ISI Web of Sciences, and Google Scholar were investigated. 4 randomized controlled studies involving 212 participants were included in the meta-analysis.
   Results: The result obtained after the final Reiki application was evaluated in VAS pain score. When Reiki (n = 104) group was compared with control group (n = 108), standardized mean difference was observed to be -0.927 (95% CI: -1.867 to 0.0124). Reiki was observed to cause a statistically significant decrease in VAS score.
   Conclusion: Consequently, this meta-analysis revealed that Reiki was an effective approach in relieving the pain. (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Dogan, Melike Demir] Gumushane Univ, Fac Hlth Sci, Baglarbasi Mahallesi, TR-29100 Gumushane, Turkey.
C3 Gumushane University
RP Dogan, MD (corresponding author), Gumushane Univ, Fac Hlth Sci, Baglarbasi Mahallesi, TR-29100 Gumushane, Turkey.
EM melekdm@gmail.com
RI Demir Doğan, Melike/B-5455-2017
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Birocco N, 2012, AM J HOSP PALLIAT ME, V29, P290, DOI 10.1177/1049909111420859
   Brathovde Angela, 2006, Holist Nurs Pract, V20, P95
   Carlsson CPO, 2001, CLIN J PAIN, V17, P296, DOI 10.1097/00002508-200112000-00003
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   Demir Melike, 2015, Asian Pac J Cancer Prev, V16, P4859, DOI 10.7314/apjcp.2015.16.12.4859
   Doenges M. E., 2013, NURSING DIAGNOSIS MA, P550
   Driver L., 2007, POLITICS PAIN BALANC
   Ersek M., 2007, MED SURG NURSING ASS, P125
   Everdingen MHJVDBV, 2007, ANN ONCOL, V18, P1437, DOI 10.1093/annonc/mdm056
   Gallob Robin, 2003, J N Y State Nurses Assoc, V34, P9
   Goodrich C, 2006, J NURS EDUC, V45, P140, DOI 10.3928/01484834-20060301-09
   Hussein A.Nijmeh Mohammed., 2008, J HOSP PALLIAT NURS, V10, P198, DOI DOI 10.1097/01.NJH.0000319161.97477.B0
   Lee MS, 2008, INT J CLIN PRACT, V62, P947, DOI 10.1111/j.1742-1241.2008.01729.x
   Midilli TS, 2015, PAIN MANAG NURS, V16, P388, DOI 10.1016/j.pmn.2014.09.005
   National Center for Complementary and Alternative Medicine, 2008, US COMPL ALT MED US
   Okifuji A, 2007, MED CLIN N AM, V91, P45, DOI 10.1016/j.mcna.2006.10.008
   Olson K, 2003, J PAIN SYMPTOM MANAG, V26, P990, DOI 10.1016/S0885-3924(03)00334-8
   Pocotte SL, 2008, REHABIL NURS, V33, P231, DOI 10.1002/j.2048-7940.2008.tb00233.x
   Richeson NE, 2010, RES GERONTOL NURS, V3, P187, DOI 10.3928/19404921-20100601-01
   The Center for Reiki Research, 2010, RES CONCL
   Thrane S, 2014, PAIN MANAG NURS, V15, P897, DOI 10.1016/j.pmn.2013.07.008
   Toms R, 2011, CRIT CARE NURS Q, V34, P213, DOI 10.1097/CNQ.0b013e31821c684d
   vanderVaart S, 2011, BMJ OPEN, V1, DOI 10.1136/bmjopen-2010-000021
   Vitale Anne, 2007, Holist Nurs Pract, V21, P167
   Whelan Kathleen M, 2003, Holist Nurs Pract, V17, P209
NR 26
TC 52
Z9 66
U1 1
U2 62
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD MAY
PY 2018
VL 31
BP 384
EP 387
DI 10.1016/j.ctcp.2018.02.020
PG 4
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GG2KG
UT WOS:000432520800061
PM 29551623
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Pillai, GG
   Andrade, CJ
   Ligibel, JA
   Basu, P
   Cohen, L
   Khan, IA
   Mustian, KM
   Puthiyedath, R
   Dhiman, KS
   Lao, LX
   Ghelman, R
   Guido, PC
   Lopez, G
   Gallego-Perez, DF
   Salicrup, LA
AF Mao, Jun J.
   Pillai, Geetha Gopalakrishna
   Andrade, Carlos Jose
   Ligibel, Jennifer A.
   Basu, Partha
   Cohen, Lorenzo
   Khan, Ikhlas A.
   Mustian, Karen M.
   Puthiyedath, Rammanohar
   Dhiman, Kartar Singh
   Lao, Lixing
   Ghelman, Ricardo
   Caceres Guido, Paulo
   Lopez, Gabriel
   Gallego-Perez, Daniel F.
   Salicrup, Luis Alejandro
TI Integrative oncology: Addressing the global challenges of cancer
   prevention and treatment
SO CA-A CANCER JOURNAL FOR CLINICIANS
LA English
DT Article
DE cancer prevention; complementary; alternative; and integrative medicine;
   global health; health policy; survivorship
ID RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; ALTERNATIVE MEDICINE USE;
   STAGE BREAST-CANCER; STRESS REDUCTION; MASSAGE THERAPY; AMERICAN
   SOCIETY; CLINICAL-TRIALS; SHAM ACUPUNCTURE; SUPPLEMENT USE
AB The increase in cancer incidence and mortality is challenging current cancer care delivery globally, disproportionally affecting low- and middle-income countries (LMICs) when it comes to receiving evidence-based cancer prevention, treatment, and palliative and survivorship care. Patients in LMICs often rely on traditional, complementary, and integrative medicine (TCIM) that is more familiar, less costly, and widely available. However, spheres of influence and tensions between conventional medicine and TCIM can further disrupt efforts in evidence-based cancer care. Integrative oncology provides a framework to research and integrate safe, effective TCIM alongside conventional cancer treatment and can help bridge health care gaps in delivering evidence-informed, patient-centered care. This growing field uses lifestyle modifications, mind and body therapies (eg, acupuncture, massage, meditation, and yoga), and natural products to improve symptom management and quality of life among patients with cancer. On the basis of this review of the global challenges of cancer control and the current status of integrative oncology, the authors recommend: 1) educating and integrating TCIM providers into the cancer control workforce to promote risk reduction and culturally salient healthy life styles; 2) developing and testing TCIM interventions to address cancer symptoms or treatment-related adverse effects (eg, pain, insomnia, fatigue); and 3) disseminating and implementing evidence-based TCIM interventions as part of comprehensive palliative and survivorship care so patients from all cultures can live with or beyond cancer with respect, dignity, and vitality. With conventional medicine and TCIM united under a cohesive framework, integrative oncology may provide citizens of the world with access to safe, effective, evidence-informed, and culturally sensitive cancer care.
C1 [Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, 1275 York Ave, New York, NY 10021 USA.
   [Pillai, Geetha Gopalakrishna] WHO, Tradit Complementary & Integrat Med Unit, Serv Delivery & Safety Dept, Geneva, Switzerland.
   [Andrade, Carlos Jose] Brazilian Natl Canc Inst, Rio De Janeiro, Brazil.
   [Ligibel, Jennifer A.] Dana Farber Canc Inst, Leonard P Zakim Ctr Integrat Therapies & Hlth Liv, Boston, MA 02115 USA.
   [Ligibel, Jennifer A.] Harvard Med Sch, Boston, MA 02115 USA.
   [Basu, Partha] WHO, Int Agcy Res Canc, Lyon, France.
   [Cohen, Lorenzo; Lopez, Gabriel] Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, Integrat Med Program, Houston, TX 77030 USA.
   [Khan, Ikhlas A.] Univ Mississippi, Natl Ctr Nat Prod Res, Jackson, MS 39216 USA.
   [Mustian, Karen M.] Univ Rochester, Med Ctr, Wilmot Canc Inst, Dept Surg, Rochester, NY 14642 USA.
   [Puthiyedath, Rammanohar] Amrita Vishwa Vidyapeetham Univ, Amritapuri, Kerala, India.
   [Dhiman, Kartar Singh] Cent Council Res Ayurved Sci, New Delhi, India.
   [Lao, Lixing] Virginia Univ Integrat Med, Fairfax, VA USA.
   [Ghelman, Ricardo] Univ Sao Paulo, Brazilian Acad Consortium Integrat Hlth, Sao Paulo, Brazil.
   [Caceres Guido, Paulo] Garrahan Pediat Hosp, Pharmacokinet & Res Clin Pharmacol & Integrat Med, Buenos Aires, DF, Argentina.
   [Caceres Guido, Paulo; Gallego-Perez, Daniel F.] Tradit Complementary & Integrat Med Network Amer, Sao Paulo, Brazil.
   [Gallego-Perez, Daniel F.] Boston Univ, Sch Publ Hlth, Boston, MA USA.
   [Salicrup, Luis Alejandro] NCI, Ctr Global Hlth, NIH, Rockville, MD USA.
   [Salicrup, Luis Alejandro] NCI, Off Canc Complementary & Alternat Med, Div Canc Treatment & Diag, NIH, Rockville, MD USA.
C3 Memorial Sloan Kettering Cancer Center; World Health Organization;
   National Cancer Institute (Inca); Harvard University; Harvard University
   Medical Affiliates; Dana-Farber Cancer Institute; Harvard University;
   Harvard Medical School; World Health Organization; International Agency
   for Research on Cancer (IARC); University of Texas System; UTMD Anderson
   Cancer Center; University of Mississippi; University of Rochester;
   Amrita Vishwa Vidyapeetham; Universidade de Sao Paulo; Hospital de
   Pediatria Doctor Juan Garrahan; Boston University; National Institutes
   of Health (NIH) - USA; NIH National Cancer Institute (NCI); National
   Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI);
   NIH Division of Cancer Treatment & Diagnosis
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
EM maoj@mskcc.org
RI Caceres Guido, Paulo/ABH-4806-2020; Khan, Ikhlas/AAA-1490-2020; P,
   Rammanohar/D-6818-2011; Lao, Lixing/P-9107-2019; Ghelman,
   Ricardo/ABA-1854-2021
OI Mao, Jun/0000-0001-9229-0380; Gallego-Perez, Daniel
   Felipe/0000-0002-0975-4349; P, Rammanohar/0000-0002-0709-1801; Ghelman,
   Ricardo/0000-0002-6700-6488
FU MSK National Institutes of Health/National Cancer Institute Cancer
   Center grant [P30 CA008748]; Herbal Education and Research in Oncology
   Program by the Laurance S. Rockefeller Foundation; Tibet Cheezheng
   Tibetan Medicine Company, Ltd.; National Cancer Institute [P30CA008748]
   Funding Source: NIH RePORTER
FX Jun J. Mao and Memorial Sloan Kettering Cancer Center (MSK) staff are
   supported in part by an MSK National Institutes of Health/National
   Cancer Institute Cancer Center grant (P30 CA008748) and by the Herbal
   Education and Research in Oncology Program made possible by the Laurance
   S. Rockefeller Foundation. Jun J. Mao reports research funding provided
   to MSK from Tibet Cheezheng Tibetan Medicine Company, Ltd. Lorenzo Cohen
   receives royalties from the book, Anticancer Living: Transform Your Life
   and Health With the Mix of Six. All remaining authors report no
   conflicts of interest.
CR Afungchwi GM, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1719-y
   Agarwal R, NCCN CLIN PRACTICE G
   Aggarwal BB, 2006, EXPERT OPIN THER TAR, V10, P87, DOI 10.1517/14728222.10.1.87
   Alegbeleye BJ., 2020, INT J SCI ADV, V1, P49
   Aliyu UM, 2017, NIGER J CLIN PRACT, V20, P1576, DOI 10.4103/njcp.njcp_88_17
   American Association for Cancer Research(AACR), AACR CANC PROGR REP
   American Association for the Advancement of Science, 2014, SCIENCE, V346, P1564
   Andersen SR, 2013, ACTA ONCOL, V52, P336, DOI 10.3109/0284186X.2012.745948
   Anderson JG, 2012, J ALTERN COMPLEM MED, V18, P235, DOI 10.1089/acm.2011.0022
   [Anonymous], Resolution adopted by the General Assembly on 25 September 2015, A/RES/70/1para.21
   [Anonymous], 2018, Cancer facts and figures
   [Anonymous], 67 WORLD HLTH ASS 20
   [Anonymous], Continuous update project expert report 2018. diet, nutrition
   Armer JS, 2020, JNCI CANCER SPECT, V4, DOI 10.1093/jncics/pkz098
   Asiimwe JB, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/9963038
   Asiki G, 2016, ACTA PAEDIATR, V105, P191, DOI 10.1111/apa.13252
   Ataguba JEO, 2012, HEALTH ECON POLICY L, V7, P309, DOI 10.1017/S1744133110000356
   Bae JY, 2020, PLANTA MED, V86, P144, DOI 10.1055/a-1037-4051
   Bao T, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.0681
   Barni MV, 2012, ONCOL REP, V27, P1041, DOI 10.3892/or.2012.1630
   Ben-Arye E, 2013, MED ONCOL, V30, DOI 10.1007/s12032-013-0511-1
   Berger AM., NCCN CLIN PRACTICE G
   Bhoo-Pathy N, 2017, EUR J CANCER, V74, P26, DOI 10.1016/j.ejca.2016.12.014
   Bower Julienne E, 2005, Cancer Control, V12, P165
   Bower JE, 2021, J CLIN ONCOL, V39, P3473, DOI 10.1200/JCO.21.00279
   Boyd C, 2016, PAIN MED, V17, P1553, DOI 10.1093/pm/pnw100
   Brahmi Sami Aziz, 2011, PAN AFR MED J, V10
   Brazilian Academic Consortium for Integrative Health, BRAZ AC CONS INT HLT
   Brenner DR, 2019, PREV MED, V122, P49, DOI 10.1016/j.ypmed.2019.03.014
   Broom Alex, 2009, Oman Med J, V24, P99, DOI 10.5001/omj.2009.24
   Brown KF, 2018, BRIT J CANCER, V118, P1130, DOI 10.1038/s41416-018-0029-6
   Bruni L, 2021, PREV MED, V144, DOI 10.1016/j.ypmed.2020.106399
   BVS MTCI Americas, JORN INT MED INT HOS
   Guido PC, 2015, EUR J INTEGR MED, V7, P5, DOI 10.1016/j.eujim.2014.06.010
   Carlson LE, 2004, PSYCHONEUROENDOCRINO, V29, P448, DOI 10.1016/S0306-4530(03)00054-4
   Carlson LE, 2013, J CLIN ONCOL, V31, P3119, DOI 10.1200/JCO.2012.47.5210
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   Chen G, 2015, J HUAZHONG U SCI-MED, V35, P808, DOI 10.1007/s11596-015-1511-5
   Chen Z, 2008, J ALTERN COMPLEM MED, V14, P1049, DOI 10.1089/acm.2008.0039
   China's State Council Information Office, 2016 WHIT PAP TRAD
   Chinese Medicine Council of Hong Kong, DEV CHIN MED HONG KO
   Choedon T, 2010, J ETHNOPHARMACOL, V129, P208, DOI 10.1016/j.jep.2010.03.011
   Clairet AL, 2019, MED ONCOL, V36, DOI 10.1007/s12032-019-1267-z
   Communication Strategy Research Office Center for International Communication Studies, 2015, 2015 CHINA NATL IMAG
   Costa PT., 2015, HEMATOL ONCOL, V33, P280
   Courneya KS, 2008, CURR ONCOL, V15, P262
   D'Alessandro E, 2013, ACUPUNCT MED, V31, P23, DOI 10.1136/acupmed-2012-010206
   Campos MPD, 2011, J ALTERN COMPLEM MED, V17, P505, DOI 10.1089/acm.2010.0571
   De Pergola G, 2013, J OBES, V2013, DOI 10.1155/2013/291546
   Defo BK, 2014, GLOBAL HEALTH ACTION, V7, P17, DOI 10.3402/gha.v7.22443
   del Giglio Adriana Braz, 2013, Journal of Dietary Supplements, V10, P325, DOI 10.3109/19390211.2013.830676
   Denlinger C., 2016, NCCN Clinical Practice Guidelines in Oncology - Survivorship, Version 2
   Department of Primary Care Office of Health Care Ministry of Health of Brazil, 2008, NATL POL INT COMPL P
   Desai AG, 2008, CURR DRUG METAB, V9, P581, DOI 10.2174/138920008785821657
   Deshmukh V, 2014, SUPPORT CARE CANCER, V22, P3007, DOI 10.1007/s00520-014-2294-0
   Doll Richard, 2004, BMJ, V328, P1519, DOI 10.1136/bmj.38142.554479.AE
   Donoyama N, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196638
   Ettinger D S., 2015, NCCN clinical practice guidelines in oncology
   Ezzo J, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003475.pub2
   Ferlay J, 2021, INT J CANCER, V149, P778, DOI 10.1002/ijc.33588
   Fernandez T, 2003, J ETHNOPHARMACOL, V85, P81, DOI 10.1016/S0378-8741(02)00361-6
   Ferraz Ivana Santos, 2020, Enfermería Actual de Costa Rica, P196, DOI [10.15517/revenf.v0i38.37750, 10.15517/revenf.v0i38.37750]
   Fundacion Arturo Lopez Perez, TER COMPL
   Fundacion para Combatir la Leucemia (FUNDALEU), MED INT
   Gallagher EJ, 2013, DIABETES CARE, V36, pS233, DOI 10.2337/dcS13-2001
   Gallagher EJ, 2015, PHYSIOL REV, V95, P727, DOI 10.1152/physrev.00030.2014
   Gallego-Pérez DF, 2020, REV PANAM SALUD PUBL, V44, DOI 10.26633/RPSP.2020.143
   Gallicchio L, 2021, JNCI-J NATL CANCER I, V113, P1136, DOI 10.1093/jnci/djab049
   Garland SN, 2021, J CANCER SURVIV, V15, P951, DOI 10.1007/s11764-021-01001-1
   Geerse OP, 2018, CANCER-AM CANCER SOC, V124, P4435, DOI 10.1002/cncr.31723
   Gelband H, 2016, LANCET, V387, P2133, DOI 10.1016/S0140-6736(15)00755-2
   Gerson-Cwilich Raquel, 2006, Clin Transl Oncol, V8, P200
   Gilchrist SC, 2020, JAMA ONCOL, V6, P1210, DOI 10.1001/jamaoncol.2020.2045
   Giordano A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102376
   Giovannucci E, 2010, J CLIN ONCOL, V28, P4081, DOI 10.1200/JCO.2009.27.3219
   Girdhani S, 2005, J Cancer Res Ther, V1, P129
   Gomez-Martinez R, 2007, PEDIATR BLOOD CANCER, V49, P820, DOI 10.1002/pbc.21101
   Gopal S, 2021, JAMA-J AM MED ASSOC, V326, P809, DOI 10.1001/jama.2021.12778
   Grant SJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735418823266
   Greenlee H, 2017, CA-CANCER J CLIN, V67, P195, DOI 10.3322/caac.21397
   Greenlee Heather, 2014, Journal of the National Cancer Institute Monographs, P346, DOI 10.1093/jncimonographs/lgu041
   He W, 2013, J TRADIT CHIN MED, V33, P403, DOI 10.1016/S0254-6272(13)60187-9
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Henderson V, 2012, BREAST CANCER RES TR, V131, P99, DOI 10.1007/s10549-011-1738-1
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Holmboe-Ottesen G, 2012, FOOD NUTR RES, V56, DOI 10.3402/fnr.v56i0.18891
   Horneber M, 2012, INTEGR CANCER THER, V11, P187, DOI 10.1177/1534735411423920
   Hospital Israelita Albert Einstein, SUPPL THER
   Hou YN, 2019, CANCER J, V25, P357, DOI 10.1097/PPO.0000000000000403
   Hsu WC, 2015, DIABETES CARE, V38, P150, DOI 10.2337/dc14-2391
   Hu CQ, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1720239
   International Atomic Energy Agency, DIR RAD CTR DIRAC
   International Narcotics Control Board (INCB), NARC DRUGS TECHN REP
   Islami F, 2018, CA-CANCER J CLIN, V68, P31, DOI 10.3322/caac.21440
   Jeon J, 2018, ANN INTERN MED, V169, P684, DOI [10.7326/M18-1250, 10.7326/m18-1250]
   Jia Libin, 2017, Journal of the National Cancer Institute Monographs, P58, DOI [10.1093/jncimonographs/lgx007, 10.1093/jncimonographs/lgx007]
   Jiang H, 2018, JAMA NETW OPEN, V1, DOI 10.1001/jamanetworkopen.2018.0713
   Joint United Nations Programme on HIV/AIDS (UNAIDS), 2006, COLL TRAD HEAL HIV P
   Key T, 2004, PUBLIC HEALTH NUTR, V7, P187, DOI 10.1079/PHN2003588
   Kiecolt-Glaser JK, 2014, J CLIN ONCOL, V32, P1040, DOI 10.1200/JCO.2013.51.8860
   Kinkead B, 2018, CANCER-AM CANCER SOC, V124, P546, DOI 10.1002/cncr.31064
   Knaul F.M., 2011, Closing the cancer divide. A blueprint to expand access in low and middle income countries
   Krohn M, 2011, SUPPORT CARE CANCER, V19, P1303, DOI 10.1007/s00520-010-0946-2
   Kumar DRN, 2015, PAK J PHARM SCI, V28, P83
   Kumar D, 2016, SOUTH ASIAN J CANCER, V5, P8, DOI 10.4103/2278-330X.179689
   Kumar S, 2013, CURR OPIN SUPPORT PA, V7, P216, DOI 10.1097/SPC.0b013e3283610255
   Kutner JS, 2008, ANN INTERN MED, V149, P369, DOI 10.7326/0003-4819-149-6-200809160-00003
   Labidi S, 2020, B CANCER, V107, P209, DOI 10.1016/j.bulcan.2019.10.007
   Lacomba MT, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.b5396
   Ladas EJ, 2014, PEDIATR BLOOD CANCER, V61, P687, DOI 10.1002/pbc.24791
   Latorre Palma Claudia G., 2016, Journal of Dietary Supplements, V13, P221, DOI [10.3109/19390211.2015.1008612, 10.3109/19390211.2015.1008612]
   Lauby-Secretan B, 2016, NEW ENGL J MED, V375, P794, DOI 10.1056/NEJMsr1606602
   Lazarou J, 1998, JAMA-J AM MED ASSOC, V279, P1200, DOI 10.1001/jama.279.15.1200
   Lee BL, 2012, LANCET ONCOL, V13, pE95, DOI 10.1016/S1470-2045(11)70323-0
   Lengacher CA, 2016, J CLIN ONCOL, V34, P2827, DOI 10.1200/JCO.2015.65.7874
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Li JX, 2011, CURR ONCOL REP, V13, P290, DOI 10.1007/s11912-011-0169-9
   Ligibel JA, 2017, NPJ BREAST CANCER, V3, DOI 10.1038/s41523-017-0040-8
   Ligibel JA, 2014, J CLIN ONCOL, V32, P3568, DOI 10.1200/JCO.2014.58.4680
   Lim EJ, 2017, J ALTERN COMPLEM MED, V23, P8, DOI 10.1089/acm.2016.0263
   Lin PJ, 2018, CURR ONCOL REP, V20, DOI 10.1007/s11912-018-0657-2
   Linos E, 2008, JNCI-J NATL CANCER I, V100, P1352, DOI 10.1093/jnci/djn305
   Listing M, 2009, PSYCHO-ONCOLOGY, V18, P1290, DOI 10.1002/pon.1508
   Liu J, 2021, ANN PALLIAT MED, V10, P1895, DOI 10.21037/apm-20-865
   Liu J, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420944491
   Liu J, 2019, CANCER J, V25, P367, DOI 10.1097/PPO.0000000000000404
   Livingston J., 2012, Improvising Medicine in an African Oncology Ward, DOI DOI 10.1215/9780822395768
   LoConte NK, 2018, J CLIN ONCOL, V36, P83, DOI 10.1200/JCO.2017.76.1155
   de Paula LCL, 2015, J ALTERN COMPLEM MED, V21, P22, DOI 10.1089/acm.2014.0127
   Lopes Gilberto, 2019, J Glob Oncol, V5, P1, DOI 10.1200/JGO.18.00213
   Lopez G, 2019, CANCER J, V25, P311, DOI 10.1097/PPO.0000000000000401
   López-Gil S, 2017, DRUG METAB REV, V49, P338, DOI 10.1080/03602532.2017.1335750
   Ly, 2016, CANC THER ONCOL INT, V2
   Ly, 2018, J TUMOR MED PREV, V3
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   MacLeod, 2017, J NATL CANCER INST M, V2017
   Malvicini M, 2018, MOL CANCER THER, V17, P966, DOI 10.1158/1535-7163.MCT-17-0193
   Mao, 2017, J NATL CANCER INST M, V2017
   Mao JJ, 2021, JAMA ONCOL, V7, P720, DOI 10.1001/jamaoncol.2021.0310
   Mao JJ, 2017, J ONCOL PRACT, V13, pE207, DOI 10.1200/JOP.2016.015081
   Mao JJ, 2015, J CLIN ONCOL, V33, P3615, DOI 10.1200/JCO.2015.60.9412
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   Martinez R, 2020, LANCET GLOB HEALTH, V8, pE511, DOI 10.1016/S2214-109X(20)30035-8
   Mathur P, 2020, JCO GLOB ONCOL, V6, P1063, DOI 10.1200/GO.20.00122
   Mclntyre D., 2007, LEARNING EXPERIENCE
   McQuade JL, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/504507
   Boccolini PDM, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-2842-8
   Ministerio da Saude, PRAT INT E COMPL PIC
   Moadel AB, 2007, J CLIN ONCOL, V25, P4387, DOI 10.1200/JCO.2006.06.6027
   Molassiotis A, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419836501
   Molina AI, 2005, MEDICINA-BUENOS AIRE, V65, P390
   Moral-Munoz JA, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419846401
   Mustian KM, 2016, SEMIN ONCOL NURS, V32, P383, DOI 10.1016/j.soncn.2016.09.002
   Mustian Karen M, 2012, Oncol Hematol Rev, V8, P81
   Mustian KM, 2013, J CLIN ONCOL, V31, P3233, DOI 10.1200/JCO.2012.43.7707
   Nahleh Z, 2008, CURR ONCOL, V15, P271
   National Comprehensive Cancer Network (NCCN), NCCN GUID SUPP CAR
   Nekhlyudov L, 2019, JNCI-J NATL CANCER I, V111, P1120, DOI 10.1093/jnci/djz089
   Ng SSM, 2013, GASTROENTEROLOGY, V144, P307, DOI 10.1053/j.gastro.2012.10.050
   Noto Y, 2010, J ANESTH, V24, P827, DOI 10.1007/s00540-010-1028-9
   O'Hara GA, 2017, PLOS NEGLECT TROP D, V11, DOI 10.1371/journal.pntd.0005842
   Office of Cancer Complementary and Alternative Medicine National Cancer Institute, 2016, INT ACT
   Paice JA, 2016, J CLIN ONCOL, V34, P3325, DOI 10.1200/JCO.2016.68.5206
   Palliyaguru DL, 2016, MOL NUTR FOOD RES, V60, P1342, DOI 10.1002/mnfr.201500756
   Qazi AK, 2018, CARCINOGENESIS, V39, P522, DOI 10.1093/carcin/bgy024
   Rack B, 2010, BREAST CARE, V5, P395, DOI 10.1159/000322677
   Raghavendra RM, 2009, INTEGR CANCER THER, V8, P37, DOI 10.1177/1534735409331456
   Raimi IO, 2020, J HERB MED, V23, DOI 10.1016/j.hermed.2020.100371
   Rao MR, 2009, COMPLEMENT THER MED, V17, P1, DOI 10.1016/j.ctim.2008.05.005
   Reitsma MB, 2017, LANCET, V389, P1885, DOI 10.1016/S0140-6736(17)30819-X
   Rhee JY., APCA ATLAS PALLIATIV
   Riba MB, NCCN CLIN PRACTICE G
   Rocha V, 2017, J GLOB ONCOL, V3, P701, DOI 10.1200/JGO.2016.006809
   Rojas TR, 2018, INTEGR CANCER THER, V17, P52, DOI 10.1177/1534735416681642
   Rosenbaum E, 2004, SUPPORT CARE CANCER, V12, P293, DOI 10.1007/s00520-004-0599-0
   Rtveladze K, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068785
   Ruiz GG, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159857
   Samano Eliana Sueco Tibana, 2004, Sao Paulo Med. J., V122, P60
   Sánchez Ricardo, 2015, Rev. salud pública, V17, P699, DOI [10.15446/rsap.v17n5.38695, 10.15446/rsap.v17n5.38695]
   Araújo MDS, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/676984
   Secretaria de Atencao Primaria a Saude Ministerio da Saude Brasil, POL NACL PRAT INT CO
   Shah SC, 2019, J GLOB ONCOL, V5, DOI 10.1200/JGO.18.00200
   Shetty N, 2019, INDIAN J MED PAEDIAT, V40, P365, DOI 10.4103/ijmpo.ijmpo_200_17
   Shipkowski KA, 2018, FOOD CHEM TOXICOL, V118, P963, DOI 10.1016/j.fct.2018.04.007
   Sitarek P, 2020, CANCERS, V12, DOI 10.3390/cancers12102957
   Smith MC, 2003, ALTERN THER HEALTH M, V9, P40
   Soden K, 2004, PALLIATIVE MED, V18, P87, DOI 10.1191/0269216304pm874oa
   Soerjomataram I, 2012, BMC MED RES METHODOL, V12, DOI 10.1186/1471-2288-12-125
   Stubbe Dorothy E, 2018, Focus (Am Psychiatr Publ), V16, P60, DOI [10.1176/appi.focus.20170052, 10.1176/appi.focus.20170052]
   Sun LY, 2017, J GLOB ONCOL, V3, P692, DOI 10.1200/JGO.2016.007955
   Sun LY, 2018, INTEGR CANCER THER, V17, P885, DOI 10.1177/1534735418777117
   Sun LY, 2021, INTEGR CANCER THER, V20, DOI 10.1177/15347354211020105
   Sundararajan R, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-033410
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Swarm R A., 2019, NCCN Clinical Practice Guidelines in Oncology
   Tauchen J, 2019, NAT PROD RES, V33, P2718, DOI 10.1080/14786419.2018.1462180
   Thomson CA, 2016, CONTEMP CLIN TRIALS, V49, P181, DOI 10.1016/j.cct.2016.07.005
   Tian GH, 2021, J EVID-BASED MED, V14, P65, DOI 10.1111/jebm.12420
   Tiloke C, 2018, BIOMED PHARMACOTHER, V108, P457, DOI 10.1016/j.biopha.2018.09.060
   Toth M, 2013, J ALTERN COMPLEM MED, V19, P650, DOI 10.1089/acm.2012.0466
   Tovey P, 2006, INTEGR CANCER THER, V5, P232, DOI 10.1177/1534735406291493
   Trimble EL., 2017, J NATL CANCER INST M, V2017
   Tröndle M, 2021, COMPLEMENT THER MED, V58, DOI 10.1016/j.ctim.2021.102681
   Velicer CM, 2008, J CLIN ONCOL, V26, P665, DOI 10.1200/JCO.2007.13.5905
   Viscuse PV, 2017, CURR OPIN ONCOL, V29, P235, DOI 10.1097/CCO.0000000000000376
   Vyas Purvi, 2010, Ayu, V31, P417, DOI 10.4103/0974-8520.82029
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   Wang LM, 2017, JAMA-J AM MED ASSOC, V317, P2515, DOI 10.1001/jama.2017.7596
   Ward ZJ, 2021, LANCET ONCOL, V22, P1301, DOI 10.1016/S1470-2045(21)00403-4
   Weeks J, 2020, J ALTERN COMPLEM MED, V26, P82, DOI 10.1089/acm.2020.29082.jjw
   WHO, 2014, GLOBAL STATUS REPORT ON VIOLENCE PREVENTION 2014, P1
   WHO, 2013, WORLD MALARIA REPORT 2013, P1
   who, WHO reports progress in the fight against tobacco epidemic
   Wild CP., 2020, World Cancer Report: Cancer Research for Cancer Prevention
   Williams AF, 2002, EUR J CANCER CARE, V11, P254, DOI 10.1046/j.1365-2354.2002.00312.x
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
   World Health Organization, 2012, World Health Organ Tech Rep Ser, P1
   World Health Organization, 2002, Programme on Traditional Medicine. WHO Traditional Medicine Strategy 2002-2005
   Wu M, 2015, ONCOTARGET, V6, P38283, DOI 10.18632/oncotarget.5711
   Würtzen H, 2013, EUR J CANCER, V49, P1365, DOI 10.1016/j.ejca.2012.10.030
   Xiang Y, 2018, J PAIN RES, V11, P83, DOI 10.2147/JPR.S152743
   Xu YC, 2020, J PAIN SYMPTOM MANAG, V59, P966, DOI 10.1016/j.jpainsymman.2019.10.018
   Xu Yun, 2017, Journal of the National Cancer Institute Monographs, P19, DOI [10.1093/jncimonographs/lgx015, 10.1093/jncimonographs/lgx015]
   Yang MX, 2021, BIOMED PHARMACOTHER, V140, DOI 10.1016/j.biopha.2021.111727
   Yang MX, 2021, PHYTOMEDICINE, V82, DOI 10.1016/j.phymed.2021.153459
   Yeh HC, 2020, OBESITY, V28, P1678, DOI 10.1002/oby.22936
   Yeung KS, 2018, ONCOLOGY-NY, V32, P516
   Yun Hyeongjun, 2017, Journal of the National Cancer Institute Monographs, P29, DOI [10.1093/jncimonographs/lgx004, 10.1093/jncimonographs/lgx004]
   Zainal NZ, 2013, PSYCHO-ONCOLOGY, V22, P1457, DOI 10.1002/pon.3171
   Zeng YC, 2018, INTEGR CANCER THER, V17, P737, DOI 10.1177/1534735418777109
   Zetzl T, 2021, SUPPORT CARE CANCER, V29, P2973, DOI 10.1007/s00520-020-05794-2
   Zhang YB, 2020, BRIT J CANCER, V122, P1085, DOI 10.1038/s41416-020-0741-x
NR 232
TC 325
Z9 376
U1 9
U2 178
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-9235
EI 1542-4863
J9 CA-CANCER J CLIN
JI CA-Cancer J. Clin.
PD MAR
PY 2022
VL 72
IS 2
BP 144
EP 164
DI 10.3322/caac.21706
EA NOV 2021
PG 21
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA ZO0AX
UT WOS:000715927300001
PM 34751943
OA gold
DA 2026-01-16
ER

PT J
AU Majithia, N
   Loprinzi, CL
   Smith, TJ
AF Majithia, Neil
   Loprinzi, Charles L.
   Smith, Thomas J.
TI New Practical Approaches to Chemotherapy-Induced Neuropathic Pain:
   Prevention, Assessment, and Treatment
SO ONCOLOGY-NEW YORK
LA English
DT Article
ID INDUCED PERIPHERAL NEUROPATHY; OXALIPLATIN-INDUCED NEUROPATHY;
   PLACEBO-CONTROLLED TRIAL; ACETYL-L-CARNITINE; QUALITY-OF-LIFE;
   OVARIAN-CANCER PATIENTS; RANDOMIZED PHASE-II; CISPLATIN-INDUCED
   TOXICITIES; CELL LUNG-CANCER; DOUBLE-BLIND
AB Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most disabling and demoralizing problems that arise for cancer survivors. When investigating symptoms of numbness, tingling, or pain in the extremities, it is critical to determine whether the problem is neuropathic, somatic, or mixed. If the diagnosis is CIPN, it is important to weigh the potential benefits and harms of possible treatment options, and to devise an evidence-based multimodality treatment program. Such programs may include mixtures of opioid and nonopioid adjunctive medications, based on evidence from CIPN trials, and also extrapolation from trials in patients with other neuropathic pain syndromes-although such extrapolating must be done with caution, since other syndromes sometimes respond to agents that CIPN does not respond to. Other components of a successful program might include exercise; and possibly neuromodulation via acupuncture, spinal cord electrical stimulation, or neurocutaneous stimulation. There is good randomized trial evidence that most of the anticonvulsants and tricyclic antidepressants typically prescribed for neuropathic pain have little or no effect on CIPN, but there is some evidence of efficacy for duloxetine-however, clinical practice with regard to pharmacologic treatment of CIPN often does not reflect these data. We review here the recommendations of the American Society of Clinical Oncology, as well as some new and promising approaches to neuropathy, including new neuromodulation techniques.
C1 [Majithia, Neil; Loprinzi, Charles L.] Mayo Clin, Rochester, MN 55905 USA.
   [Smith, Thomas J.] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA.
C3 Mayo Clinic; Johns Hopkins University; Johns Hopkins Medicine
RP Majithia, N (corresponding author), Mayo Clin, Rochester, MN 55905 USA.
OI Smith, Thomas/0000-0003-3040-6434
CR Abd-Elsayed A, 2016, J CLIN ANESTH, V28, P74, DOI 10.1016/j.jclinane.2015.08.011
   Adam M.P., 1993, GeneReviews
   Albers JW, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005228.pub4
   Argyriou AA, 2006, NEUROLOGY, V67, P2253, DOI 10.1212/01.wnl.0000249344.99671.d4
   Barton DL, 2011, SUPPORT CARE CANCER, V19, P833, DOI 10.1007/s00520-010-0911-0
   Bianchi G, 2005, EUR J CANCER, V41, P1746, DOI 10.1016/j.ejca.2005.04.028
   Boardman LA, 2008, OBSTET GYNECOL, V112, P579, DOI 10.1097/AOG.0b013e3181827c77
   Boora GK, 2016, CANCER MED-US, V5, P631, DOI 10.1002/cam4.625
   Brami C, 2016, CRIT REV ONCOL HEMAT, V98, P325, DOI 10.1016/j.critrevonc.2015.11.014
   Bruera E, 2004, J CLIN ONCOL, V22, P185, DOI 10.1200/JCO.2004.03.172
   Bryson Evan, 2014, Int J Pharm Compd, V18, P504
   Burakgazi AZ, 2011, NEUROLOGY, V77, P980, DOI 10.1212/WNL.0b013e31822cfc59
   Carozzi VA, 2015, NEUROSCI LETT, V596, P90, DOI 10.1016/j.neulet.2014.10.014
   Cassidy J, 1998, CANCER CHEMOTH PHARM, V41, P161
   Cata JP, 2004, J PAIN SYMPTOM MANAG, V27, P72, DOI 10.1016/j.jpainsymman.2003.05.007
   Chu SH, 2015, SUPPORT CARE CANCER, V23, P513, DOI 10.1007/s00520-014-2408-8
   Coyne Patrick J, 2013, J Pain Palliat Care Pharmacother, V27, P359, DOI 10.3109/15360288.2013.847519
   Barrio PD, 2015, J NATL COMPR CANC NE, V13, P417, DOI 10.6004/jnccn.2015.0057
   De Vos FYFL, 2005, GYNECOL ONCOL, V97, P60, DOI 10.1016/j.ygyno.2004.11.052
   Dowell D, 2016, JAMA-J AM MED ASSOC, V315, P1624, DOI 10.1001/jama.2016.1464
   Durand JP, 2012, ANN ONCOL, V23, P200, DOI 10.1093/annonc/mdr045
   Ezendam NPM, 2014, GYNECOL ONCOL, V135, P510, DOI 10.1016/j.ygyno.2014.09.016
   Fallon MT, 2015, SUPPORT CARE CANCER, V23, P2769, DOI 10.1007/s00520-015-2642-8
   Frederiks CN, 2015, CANCER TREAT REV, V41, P935, DOI 10.1016/j.ctrv.2015.10.010
   Gallardo D, 1999, INT J GYNECOL CANCER, V9, P225
   GANDARA DR, 1995, J CLIN ONCOL, V13, P490, DOI 10.1200/JCO.1995.13.2.490
   Gelmon K, 1999, J CLIN ONCOL, V17, P3038, DOI 10.1200/JCO.1999.17.10.3038
   Gewandter JS, 2014, SUPPORT CARE CANCER, V22, P1807, DOI 10.1007/s00520-014-2158-7
   Ghoreishi Z, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-355
   Gilron I, 2005, NEW ENGL J MED, V352, P1324, DOI 10.1056/NEJMoa042580
   Gilron I, 2015, PAIN, V156, P1440, DOI 10.1097/j.pain.0000000000000149
   Gilron I, 2015, MAYO CLIN PROC, V90, P532, DOI 10.1016/j.mayocp.2015.01.018
   Gilron I, 2009, LANCET, V374, P1252, DOI 10.1016/S0140-6736(09)61081-3
   Glover D, 2003, MELANOMA RES, V13, P619, DOI 10.1097/00008390-200312000-00012
   Greenlee H, 2016, J CLIN ONCOL, V34, DOI 10.1200/JCO.2016.34.15_suppl.10002
   Grisold W, 2012, NEURO-ONCOLOGY, V14, P45, DOI 10.1093/neuonc/nos203
   Guo Y, 2014, SUPPORT CARE CANCER, V22, P1223, DOI 10.1007/s00520-013-2075-1
   Hammack JE, 2002, PAIN, V98, P195, DOI 10.1016/S0304-3959(02)00047-7
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Hershman DL, 2013, J CLIN ONCOL, V31, P2627, DOI 10.1200/JCO.2012.44.8738
   Hilpert F, 2005, SUPPORT CARE CANCER, V13, P797, DOI 10.1007/s00520-005-0782-y
   Hiom S, 2015, BRIT J DERMATOL, V173, P300, DOI 10.1111/bjd.13624
   Hirayama Y, 2015, INT J CLIN ONCOL, V20, P866, DOI 10.1007/s10147-015-0810-y
   HOVESTADT A, 1992, J NEUROL, V239, P143, DOI 10.1007/BF00833914
   Hwang KH, 2016, EUR J ONCOL NURS, V21, P215, DOI 10.1016/j.ejon.2015.10.007
   Kanat O, 2003, MED ONCOL, V20, P237, DOI 10.1385/MO:20:3:237
   Kautio AL, 2008, J PAIN SYMPTOM MANAG, V35, P31, DOI 10.1016/j.jpainsymman.2007.02.043
   Kautio AL, 2009, ANTICANCER RES, V29, P2601
   Kemp G, 1996, J CLIN ONCOL, V14, P2101, DOI 10.1200/JCO.1996.14.7.2101
   Kim JH, 2015, GYNECOL ONCOL, V136, P453, DOI 10.1016/j.ygyno.2015.01.524
   Kleckner I, 2016, J CLIN ONCOL S, V34
   Koeppen S, 2004, J CANCER RES CLIN, V130, P153, DOI 10.1007/s00432-003-0524-9
   Kono T, 2013, CANCER CHEMOTH PHARM, V72, P1283, DOI 10.1007/s00280-013-2306-7
   Kottschade LA, 2011, SUPPORT CARE CANCER, V19, P1769, DOI 10.1007/s00520-010-1018-3
   Kroigård T, 2014, EUR J NEUROL, V21, P623, DOI 10.1111/ene.12353
   Lamer TJ, 2016, MAYO CLIN PROC, V91, P246, DOI 10.1016/j.mayocp.2015.12.001
   Leong SS, 2003, J CLIN ONCOL, V21, P1767, DOI 10.1200/JCO.2003.11.005
   Loprinzi CL, 2014, J CLIN ONCOL, V32, P997, DOI 10.1200/JCO.2013.52.0536
   Loprinzi CL, 2011, J CLIN ONCOL, V29, P1472, DOI 10.1200/JCO.2010.33.0308
   Lorusso D, 2003, ANN ONCOL, V14, P1086, DOI 10.1093/annonc/mdg301
   Maestri A, 2005, TUMORI J, V91, P135, DOI 10.1177/030089160509100206
   Majithia N, 2016, SUPPORT CARE CANCER, V24, P2807, DOI 10.1007/s00520-016-3177-3
   Marineo G, 2012, J PAIN SYMPTOM MANAG, V43, P87, DOI 10.1016/j.jpainsymman.2011.03.015
   Moore DH, 2003, J CLIN ONCOL, V21, P4207, DOI 10.1200/JCO.2003.02.086
   National Comprehensive Cancer Network, 2016, NAT COMPR CLIN PRACT
   Nishioka M, 2011, INT J CLIN ONCOL, V16, P322, DOI 10.1007/s10147-010-0183-1
   Oki E, 2015, INT J CLIN ONCOL, V20, P767, DOI 10.1007/s10147-015-0784-9
   Olsen Y, 2016, JAMA-J AM MED ASSOC, V315, P1577, DOI 10.1001/jama.2016.1910
   Pachman DR, 2015, J CLIN ONCOL, V33, P3416, DOI 10.1200/JCO.2014.58.8533
   Pachman DR, 2015, J NATL COMPR CANC NE, V13, P1097, DOI 10.6004/jnccn.2015.0134
   Pisano C, 2003, CLIN CANCER RES, V9, P5756
   Planting AST, 1999, ANN ONCOL, V10, P693, DOI 10.1023/A:1008353505916
   Rao RD, 2008, CANCER, V112, P2802, DOI 10.1002/cncr.23482
   Rao RD, 2007, CANCER-AM CANCER SOC, V110, P2110, DOI 10.1002/cncr.23008
   Reeves BN, 2012, CANCER-AM CANCER SOC, V118, P5171, DOI 10.1002/cncr.27489
   Roberts JA, 1997, GYNECOL ONCOL, V67, P172, DOI 10.1006/gyno.1997.4832
   Shinde SS, 2016, SUPPORT CARE CANCER, V24, P547, DOI 10.1007/s00520-015-2807-5
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Smith TJ, 2015, MAYO CLIN PROC, V90, P1428, DOI 10.1016/j.mayocp.2015.08.009
   Smith TJ, 2012, J CLIN ONCOL, V30, P880, DOI 10.1200/JCO.2011.38.5161
   Smith TJ, 2010, J PAIN SYMPTOM MANAG, V40, P883, DOI 10.1016/j.jpainsymman.2010.03.022
   Starkweather AR, 2015, RES NURS HEALTH, V38, P29, DOI 10.1002/nur.21632
   Stevinson C, 2009, INT J GYNECOL CANCER, V19, P73, DOI 10.1111/IGC.0b013e31819902ec
   Storey Dawn J, 2010, J Pain Symptom Manage, V39, pe2, DOI 10.1016/j.jpainsymman.2010.02.004
   Streckmann F, 2014, ANN ONCOL, V25, P493, DOI 10.1093/annonc/mdt568
   VANDERHOOP RG, 1990, NEW ENGL J MED, V322, P89, DOI 10.1056/NEJM199001113220204
   VANGERVEN JMA, 1994, J NEUROL, V241, P432
   VANKOOTEN B, 1992, ARCH NEUROL-CHICAGO, V49, P1027, DOI 10.1001/archneur.1992.00530340043016
   von Delius S, 2007, INVEST NEW DRUG, V25, P173, DOI 10.1007/s10637-006-9010-y
   Zhang RX, 2012, INT J COLORECTAL DIS, V27, P1645, DOI 10.1007/s00384-012-1509-4
   Zimmerman C, 2016, SUPPORT CARE CANCER, V24, P1071, DOI 10.1007/s00520-015-2876-5
NR 91
TC 52
Z9 58
U1 1
U2 18
PU UBM MEDICA
PI NORWALK
PA 535 CONNECTICUT AVE, STE 300, NORWALK, CT 06854 USA
SN 0890-9091
J9 ONCOLOGY-NY
JI Oncology-NY
PD NOV
PY 2016
VL 30
IS 11
BP 1020
EP 1029
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA EI0WC
UT WOS:000392194900011
PM 27854104
DA 2026-01-16
ER

PT J
AU Alsabri, M
   Carfagnini, C
   Amin, M
   Castilo, F
   Lewis, J
   Ashkar, M
   Hamzah, M
   Mohamed, N
   Saker, M
   Mahgerefteh, J
   Victor, RS
   Peichev, M
   Kupferman, F
   Viswanathan, K
AF Alsabri, Mohammed
   Carfagnini, Christina
   Amin, Mody
   Castilo, Fiorella
   Lewis, Jeremy
   Ashkar, Mohammad
   Hamzah, Mohammed
   Mohamed, Nader
   Saker, Mohammed
   Mahgerefteh, Joseph
   Victor, Rosemarie St.
   Peichev, Mario
   Kupferman, Fernanda
   Viswanathan, Kusum
TI Complementary and alternative medicine for children with sickle cell
   disease: A systematic review
SO BLOOD REVIEWS
LA English
DT Review
DE Sickle cell disease; Children; Pediatric hematology
ID RANDOMIZED CONTROLLED-TRIAL; PAIN; MANAGEMENT; CANCER
AB Background: Complementary and alternative medicine (CAM) is a popular alternative to opioid and other an-algesics in sickle cell disease (SCD). We review the effectiveness, prevalence, and factors associated with CAM use in the pediatric SCD population.Methods: The review protocol was created based on Preferred Reporting Items for Systematic Reviews and Meta -Analyses guidelines. A literature search was conducted in MEDLINE, Embase, Cochrane Library, PubMed, and Web of Science.Results: Twenty-four studies were examined. The prevalence of CAM use in pediatric patients with SCD ranged from 36 to 84.5%. Common inpatient CAM interventions were yoga, virtual reality, and acupuncture, which decreased pain scale scores. Outpatient CAMs were consisted of cognitive behavioral therapy, massage therapy, and guided-imagery, which increased pain tolerability and decreased pain scale scores.Conclusions: CAM modalities can decrease pain scale scores. However, the impact of specific CAM modalities on emergency department visits, hospitalizations, and school absences were inconclusive.
C1 [Alsabri, Mohammed; Castilo, Fiorella; Mahgerefteh, Joseph; Victor, Rosemarie St.; Peichev, Mario; Kupferman, Fernanda; Viswanathan, Kusum] Brookdale Univ, Pediat Dept, Hosp Med Ctr, One Brooklyn Hlth, 1 Brookdale Plaza, Brooklyn, NY 11212 USA.
   [Carfagnini, Christina] Saba Univ, Sch Med, The Bottom, Netherlands.
   [Amin, Mody] Univ Buffalo, Internal Med Dept, 955 Main St, Buffalo, NY 14260 USA.
   [Lewis, Jeremy] St Marys Hosp, Dept Gen Surg, 56 Franklin St, Waterbury, CT 06706 USA.
   [Ashkar, Mohammad] New York Inst Technol, Coll Osteopath Med, Old Westbury, NY USA.
   [Saker, Mohammed] Childrens Hosp Montefiore, Med Ctr, Albert Einstein Coll Med, Bronx, NY USA.
   [Mohamed, Nader] SUNY Downstate, Coll Med, Brooklyn, NY USA.
   [Hamzah, Mohammed] Cleveland Clin Childrens Hosp, Dept Pediat Crit Care, Cleveland, OH USA.
   [Alsabri, Mohammed] Children Hosp Philadelphia, Attending Pediat Emergency Med, 3401 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   New York Institute Technology; Montefiore Medical Center; Albert
   Einstein College of Medicine; Childrens Hospital at Montefiore; Yeshiva
   University; State University of New York (SUNY) System; SUNY Downstate
   Health Sciences University; Cleveland Clinic Foundation; University of
   Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia
RP Alsabri, M (corresponding author), Children Hosp Philadelphia, Attending Pediat Emergency Med, 3401 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
EM alsabri5000@gmail.com; c.carfagnini_037@saba.edu; modyamin@buffalo.edu;
   mashka01@nyit.edu; hamzahm@ccf.org; nader.mohamed@downstate.edu;
   msakr@montefiore.org
RI Hamzah, Mohammed/AAU-9461-2020
CR Agrawal AK, 2018, PEDIATR BLOOD CANCER, V66
   Akinsulie AO, 2005, J TROP PEDIATRICS, V51, P200, DOI 10.1093/tropej/fmh097
   Angelopoulou E, 2020, COMPLEMENT THER MED, P49
   [Anonymous], 2021, Complementary, alternative, or integrative health: What's in a name?
   [Anonymous], 2022, Covidence systematic review software
   April KT, 2011, RHEUM DIS CLIN N AM, V37, P85, DOI 10.1016/j.rdc.2010.11.011
   Barakat LP, 2010, J PEDIAT HEMATOL ONC, V32, P540, DOI 10.1097/MPH.0b013e3181e793f9
   Bhushan D, 2015, MED ACUPUNCT, V27, P461, DOI 10.1089/acu.2015.1140
   Bishop FL, 2010, PEDIATRICS, V125, P768, DOI 10.1542/peds.2009-1775
   Bodhise Paul Brown, 2004, Hematology, V9, P235, DOI 10.1080/10245330410001701495
   Broome M E, 2001, J Natl Black Nurses Assoc, V12, P6
   Claster S, 2003, BRIT MED J, V327, P1151, DOI 10.1136/bmj.327.7424.1151
   Dampier C, 2004, PEDIATR BLOOD CANCER, V43, P674, DOI 10.1002/pbc.20162
   Dampier C, 2017, J PAIN, V18, P490, DOI 10.1016/j.jpain.2016.12.016
   Darbari DS, 2017, HEMATOL-AM SOC HEMAT, P534, DOI 10.1182/asheducation-2017.1.534
   Darnall BD, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.13401
   Dobson C, 2015, APPL NURS RES, V28, P384, DOI 10.1016/j.apnr.2014.12.005
   Dobson CE, 2014, AM J NURS, V114, P26, DOI 10.1097/01.NAJ.0000445680.06812.6a
   Edwards CL, 2005, INT J BEHAV MED, V12, P171, DOI 10.1207/s15327558ijbm1203_6
   Ehde DM, 2019, TRIALS, V20, DOI 10.1186/s13063-019-3761-1
   Gil KM, 2001, J PEDIATR PSYCHOL, V26, P163, DOI 10.1093/jpepsy/26.3.163
   Green-Murphy A, 2017, PEDIATR BLOOD CANCER, V64
   Heidari Z, 2022, DISABIL REHABIL, V44, P5758, DOI 10.1080/09638288.2021.1949051
   Jang A, 2017, J ALTERN COMPLEM MED, V23, P362, DOI 10.1089/acm.2016.0289
   Jatau AI, 2016, J INTERCULT ETHNOPHA, V5, P191, DOI 10.5455/jice.20160223105521
   Lemanek KL, 2009, J PEDIATR PSYCHOL, V34, P1091, DOI 10.1093/jpepsy/jsp015
   Liberati Alessandro, 2009, PLoS Med, V6, pe1000100, DOI 10.1371/journal.pmed.1000100
   Mahmood LA, 2021, COMPLEMENT THER MED, V60, DOI 10.1016/j.ctim.2021.102680
   Mahmood LA, 2020, COMPLEMENT THER MED, V49, DOI 10.1016/j.ctim.2019.102287
   Moody K, 2017, J PAIN SYMPTOM MANAG, V53, P1026, DOI 10.1016/j.jpainsymman.2016.12.351
   Murray CB, 2020, PAIN, V161, P439, DOI 10.1097/j.pain.0000000000001732
   Myrvik MP, 2012, J PEDIAT HEMATOL ONC, V34, P340, DOI 10.1097/MPH.0b013e318253f0ba
   Neri Caitlin M, 2016, Glob Adv Health Med, V5, P44, DOI [10.7453/gahmj.2015.101, 10.7453/gahmj.2015.101]
   Oshikoya KA, 2008, BMC COMPLEM ALTERN M, V8, DOI 10.1186/1472-6882-8-66
   Palermo TM, 2018, CONTEMP CLIN TRIALS, V74, P88, DOI 10.1016/j.cct.2018.10.006
   Post-White J, 2009, J PEDIATR ONCOL NURS, V26, P7, DOI 10.1177/1043454208323914
   Quinn CT, 2016, EXP BIOL MED, V241, P679, DOI 10.1177/1535370216640385
   Sanchez HC, 2015, J ALTERN COMPLEM MED, V21, P660, DOI 10.1089/acm.2014.0371
   Schardt C, 2007, BMC MED INFORM DECIS, V7, DOI 10.1186/1472-6947-7-16
   Schatz J, 2015, CLIN J PAIN, V31, P536, DOI 10.1097/AJP.0000000000000183
   Shah Nirmish, 2020, J Health Econ Outcomes Res, V7, P52, DOI [10.36469/jheor.2020.12852, 10.36469/jheor.2020.12852]
   Sibinga EMS, 2006, J ALTERN COMPLEM MED, V12, P291, DOI 10.1089/acm.2006.12.291
   Sil S, 2020, COMPLEMENT THER MED, V49, DOI 10.1016/j.ctim.2020.102348
   Sinha CB., 2019, JAMA Netw Open, V2, pel94410
   Sundd P, 2019, ANNU REV PATHOL-MECH, V14, P263, DOI 10.1146/annurev-pathmechdis-012418-012838
   Tang W, 2018, MEDICINE, V97, P1
   Thompson W, 2013, MISSISSIPPI J BEHAV, V2, P151
   Vinson R, 2014, ACAD PEDIATR, V14, P491, DOI 10.1016/j.acap.2014.04.003
   Yawn BP, 2014, JAMA-J AM MED ASSOC, V312, P1033, DOI 10.1001/jama.2014.10517
   Yoon SL, 2006, J ALTERN COMPLEM MED, V12, P995, DOI 10.1089/acm.2006.12.995
   Zebracki K, 2007, J PEDIATR PSYCHOL, V32, P1006, DOI 10.1093/jpepsy/jsm033
NR 51
TC 7
Z9 8
U1 0
U2 9
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0268-960X
EI 1532-1681
J9 BLOOD REV
JI Blood Rev.
PD MAY
PY 2023
VL 59
AR 101052
DI 10.1016/j.blre.2023.101052
EA APR 2023
PG 12
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA G2WE7
UT WOS:000987813900001
PM 36775794
DA 2026-01-16
ER

PT J
AU Medeiros, LF
   Caumo, W
   Dussán-Sarria, J
   Deitos, A
   Brietzke, A
   Laste, G
   Campos-Carraro, C
   de Souza, A
   Scarabelot, VL
   Cioato, SG
   Vercelino, R
   de Castro, AL
   Sander, A
   Belló-Klein, A
   Fregni, F
   Torres, ILS
AF Medeiros, Liciane F.
   Caumo, Wolnei
   Dussan-Sarria, Jairo
   Deitos, Alicia
   Brietzke, Aline
   Laste, Gabriela
   Campos-Carraro, Cristina
   de Souza, Andressa
   Scarabelot, Vanessa L.
   Cioato, Stefania G.
   Vercelino, Rafael
   de Castro, Alexandre L.
   Sander, Alex
   Bello-Klein, Adriane
   Fregni, Felipe
   Torres, Iraci L. S.
TI Effect of Deep Intramuscular Stimulation and Transcranial Magnetic
   Stimulation on Neurophysiological Biomarkers in Chronic Myofascial Pain
   Syndrome
SO PAIN MEDICINE
LA English
DT Article
DE Myofascial Pain; BDNF; Oxidative Parameters
ID NEUROTROPHIC FACTOR BDNF; TUMOR-NECROSIS-FACTOR; CENTRAL SENSITIZATION;
   ELECTRICAL-STIMULATION; MOTOR SYSTEM; SERUM-LEVELS; BRAIN; CORTEX;
   ACUPUNCTURE; STRESS
AB Objective. The aim was to assess the neuromodulation techniques effects (repetitive transcranial magnetic stimulation [rTMS] and deep intramuscular stimulation therapy [DIMST]) on pain intensity, peripheral, and neurophysiological biomarkers chronic myofascial pain syndrome (MPS) patients. Design. Randomized, double blind, factorial design, and controlled placebo-sham clinical trial.
   Setting. Clinical trial in the Laboratory of Pain and Neuromodulation at Hospital de Clinicas de Porto Alegre (NCT02381171).
   Subjects. We recruited women aged between 19- and 75-year old, with MPS diagnosis.
   Methods. Patients were randomized into four groups: rTMS + DIMST, rTMS + sham-DIMST, sham-rTMS + DIMST, sham-rTMS + sham-DIMST; and received 10 sessions for 20 minutes each one (rTMS and DIMST). Pain was assessed by visual analogue scale (VAS); neurophysiological parameters were assessed by transcranial magnetic stimulation; biochemical parameters were: BDNF, S100 beta, lactate dehydrogenase, inflammatory (TNF-alpha, IL6, and IL10), and oxidative stress parameters.
   Results. We observed the pain relief assessed by VAS immediately assessed before and after the intervention (P < 0.05, F-(1,F-3)= 3.494 and F-(1,F-3)= 4.656, respectively); in the sham-rTMS + DIMST group and both three active groups in relation to sham-rTMS + sham-DIMST group, respectively. There was an increase in the MEP after rTMS + sham-DIMST (P < 0.05). However, there was no change in all-peripheral parameters analyzed across the treatment (P > 0.05).
   Conclusion. Our findings add additional evidence about rTMS and DIMST in relieving pain in MPS patients without synergistic effect. No peripheral biomarkers reflected the analgesic effect of both techniques; including those related to cellular damage. Additionally, one neurophysiological parameter (increased MEP amplitude) needs to be investigated.
C1 [Medeiros, Liciane F.; Campos-Carraro, Cristina; Scarabelot, Vanessa L.; de Castro, Alexandre L.; Sander, Alex; Bello-Klein, Adriane; Torres, Iraci L. S.] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Postgrad Program Biol Sci, Rua Sarmento Leite,500 Sala 202, BR-90050170 Porto Alegre, RS, Brazil.
   [Medeiros, Liciane F.; Caumo, Wolnei; Dussan-Sarria, Jairo; Deitos, Alicia; Brietzke, Aline; Laste, Gabriela; de Souza, Andressa; Vercelino, Rafael; Torres, Iraci L. S.] HCPA, Lab Pain & Neuromodulat, Porto Alegre, RS, Brazil.
   [Caumo, Wolnei; Dussan-Sarria, Jairo; Deitos, Alicia; Brietzke, Aline; Laste, Gabriela; de Souza, Andressa; Cioato, Stefania G.; Vercelino, Rafael; Torres, Iraci L. S.] Univ Fed Rio Grande do Sul, Sch Med, Postgrad Program Med Sci, Rua Sarmento Leite,500 Sala 202, BR-90050170 Porto Alegre, RS, Brazil.
   [Caumo, Wolnei; Cioato, Stefania G.; Fregni, Felipe; Torres, Iraci L. S.] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Pharmacol, Rua Sarmento Leite,500 Sala 202, BR-90050170 Porto Alegre, RS, Brazil.
   [Fregni, Felipe] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA USA.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Universidade Federal do Rio Grande do Sul; Harvard
   University; Harvard Medical School
RP Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, ICBS, Dept Farmacol, Rua Sarmento Leite,500 Sala 202, BR-90050170 Porto Alegre, RS, Brazil.
EM iracitorres@gmail.com
RI Dussan-Sarria, Jairo Alberto/Q-2447-2016; Vercelino,
   Rafael/JCE-5256-2023; Caumo, Wolnei/Q-8728-2016; Souza,
   Anessa/Q-2446-2016; Laste, Gabriela/A-3033-2014; Fernandes Medeiros,
   Liciane/A-3626-2014; Torres, Iraci LS/G-6693-2012; Campos,
   Cristina/HLX-6444-2023
OI Dussan-Sarria, Jairo Alberto/0000-0002-1271-0638; Vercelino,
   Rafael/0000-0003-2854-5769; Caumo, Wolnei/0000-0002-5083-4658; Souza,
   Anessa/0000-0002-6608-4695; Fernandes Medeiros,
   Liciane/0000-0002-6842-7241; Fregni, Felipe/0000-0001-9359-8643; Torres,
   Iraci LS/0000-0002-3081-115X; Giotti Cioato,
   Stefania/0000-0002-1854-0713; Campos, Cristina/0000-0001-6054-4243
FU National Council for Scientific and Technological Development-CNPq;
   Graduate Research Group (GPPG) of Hospital de Clinicas de Porto Alegre
   [100196, 100276]; Coordination for the Improvement of Higher Education
   Personnel-CAPES; International Cooperation Program-CAPES [023/11]
FX This research was supported by the Brazilian funding agencies: National
   Council for Scientific and Technological Development-CNPq (Dr. I.L.S.
   Torres, W. Caumo, L.F. Medeiros; J. Dussan-Sarria, A. Souza, V.L.
   Scarabelot); Graduate Research Group (GPPG) of Hospital de Clinicas de
   Porto Alegre (Dr W. Caumo-Grant # 100196 and Dr. I.L.S. Torres #
   100276); Coordination for the Improvement of Higher Education
   Personnel-CAPES (A. Deitos); International Cooperation Program-CAPES
   (no023/11).
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Akdag MZ, 2007, ELECTROMAGN BIOL MED, V26, P99, DOI 10.1080/15368370701357866
   Altman DG, 2001, ANN INTERN MED, V134, P663, DOI 10.7326/0003-4819-134-8-200104170-00012
   Angelucci F, 2004, NEUROREPORT, V15, P717, DOI 10.1097/00001756-200403220-00029
   Antal A, 2010, J PAIN SYMPTOM MANAG, V39, P890, DOI 10.1016/j.jpainsymman.2009.09.023
   Benarroch EE, 2001, CLIN AUTON RES, V11, P343, DOI 10.1007/BF02292765
   Biggs JE, 2010, MOL PAIN, V6, DOI 10.1186/1744-8069-6-44
   Blackburn-Munro G, 2001, J NEUROENDOCRINOL, V13, P1009, DOI 10.1046/j.0007-1331.2001.00727.x
   Blackwell TS, 1996, BRIT J ANAESTH, V77, P110, DOI 10.1093/bja/77.1.110
   Cha MH, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/792765
   Cheeran B, 2008, J PHYSIOL-LONDON, V586, P5717, DOI 10.1113/jphysiol.2008.159905
   Chipchase L, 2012, CLIN NEUROPHYSIOL, V123, P1698, DOI 10.1016/j.clinph.2012.05.003
   Chu J, 2000, Electromyogr Clin Neurophysiol, V40, P503
   Cohen J, 1988, STAT POWER ANAL BEHA, DOI DOI 10.4324/9780203771587
   Couto C, 2014, CLIN J PAIN, V30, P214, DOI 10.1097/AJP.0b013e3182934b8d
   Deitos A, 2014, CLIN J PAIN
   Donato R, 2009, BBA-MOL CELL RES, V1793, P1008, DOI 10.1016/j.bbamcr.2008.11.009
   FLOHE L, 1984, METHOD ENZYMOL, V105, P114
   Gedge Laura, 2012, Front Psychiatry, V3, P12, DOI 10.3389/fpsyt.2012.00012
   Greenberg BD, 1998, LANCET, V352, P881, DOI 10.1016/S0140-6736(05)60009-8
   Greif R, 2002, ANESTHESIOLOGY, V96, P306, DOI 10.1097/00000542-200202000-00014
   Guedes R, 2008, CELL MOL NEUROBIOL, V28, P1049, DOI 10.1007/s10571-008-9279-9
   Gupta Sandeep K, 2011, Perspect Clin Res, V2, P109, DOI 10.4103/2229-3485.83221
   Haas L, 2010, NEUROCHEM RES, V35, P830, DOI 10.1007/s11064-010-0129-z
   Hallett M, 2000, NATURE, V406, P147, DOI 10.1038/35018000
   Han JS, 2004, NEUROSCI LETT, V361, P258, DOI 10.1016/j.neulet.2003.12.019
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   Huguenin L, 2005, BRIT J SPORT MED, V39, P84, DOI 10.1136/bjsm.2003.009431
   Hyuk GA, 2007, J ALTERN COMPLEM MED, V13, P617, DOI 10.1089/acm.2006.6371
   Ingebrigtsen T, 1999, NEUROSURGERY, V45, P468, DOI 10.1097/00006123-199909000-00010
   Jajte J, 2002, BIOELECTROCHEMISTRY, V57, P107, DOI 10.1016/S1567-5394(02)00059-2
   Ji RR, 2003, TRENDS NEUROSCI, V26, P696, DOI 10.1016/j.tins.2003.09.017
   Jovanovic P, 2010, BOSNIAN J BASIC MED, V10, P83, DOI 10.17305/bjbms.2010.2743
   Kaelin-Lang A, 2002, J PHYSIOL-LONDON, V540, P623, DOI 10.1113/jphysiol.2001.012801
   Karege F, 2002, PSYCHIAT RES, V109, P143, DOI 10.1016/S0165-1781(02)00005-7
   Kawasaki Y, 2008, J NEUROSCI, V28, P5189, DOI 10.1523/JNEUROSCI.3338-07.2008
   Kobayashi M, 2003, LANCET NEUROL, V2, P145, DOI 10.1016/S1474-4422(03)00321-1
   Lang UE, 2008, J AFFECT DISORDERS, V107, P255, DOI 10.1016/j.jad.2007.08.008
   Latremoliere A, 2009, J PAIN, V10, P895, DOI 10.1016/j.jpain.2009.06.012
   Le Pera D, 2001, CLIN NEUROPHYSIOL, V112, P1633, DOI 10.1016/S1388-2457(01)00631-9
   LEBEL CP, 1992, CHEM RES TOXICOL, V5, P227, DOI 10.1021/tx00026a012
   Lee SJ, 2007, AM J CHINESE MED, V35, P251, DOI 10.1142/S0192415X07004795
   Lee SH, 2008, J CHIN MED ASSOC, V71, P200, DOI 10.1016/S1726-4901(08)70104-7
   Lee YS, 2004, FREE RADICAL BIO MED, V36, P330, DOI 10.1016/j.freeradbiomed.2003.11.006
   Lefaucheur JP, 2006, NEUROLOGY, V67, P1568, DOI 10.1212/01.wnl.0000242731.10074.3c
   Lefaucheur Jean-Pascal, 2008, Expert Rev Neurother, V8, P799, DOI 10.1586/14737175.8.5.799
   Lo YL, 2005, NEUROSCI LETT, V384, P145, DOI 10.1016/j.neulet.2005.04.083
   Loo CK, 2008, INT J NEUROPSYCHOPH, V11, P131, DOI 10.1017/S1461145707007717
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Machii K, 2006, CLIN NEUROPHYSIOL, V117, P455, DOI 10.1016/j.clinph.2005.10.014
   Maeda F, 2000, EXP BRAIN RES, V133, P425, DOI 10.1007/s002210000432
   Malcangio M, 2003, TRENDS PHARMACOL SCI, V24, P116, DOI 10.1016/S0165-6147(03)00025-7
   MARKLUND SL, 1985, MUTAT RES, V148, P129, DOI 10.1016/0027-5107(85)90216-7
   Mense S, 2010, MUSCLE PAIN: UNDERSTANDING THE MECHANISMS, P1, DOI 10.1007/978-3-540-85021-2
   Mhalla A, 2011, PAIN, V152, P1478, DOI 10.1016/j.pain.2011.01.034
   Nalk AK, 2006, EUR J PAIN, V10, P573, DOI 10.1016/j.ejpain.2005.08.006
   Neyal M, 2013, CLIN NEUROL NEUROSUR, V115, P736, DOI 10.1016/j.clineuro.2012.08.028
   On AY, 2004, NEUROREHAB NEURAL RE, V18, P127, DOI 10.1177/0888439004269030
   Pagano RL, 2011, EUR J PAIN, V15, DOI 10.1016/j.ejpain.2010.08.003
   Perini F, 2005, HEADACHE, V45, P926, DOI 10.1111/j.1526-4610.2005.05135.x
   Pleger B, 2004, NEUROSCI LETT, V356, P87, DOI 10.1016/j.neulet.2003.11.037
   PRICE DD, 1983, PAIN, V17, P45, DOI 10.1016/0304-3959(83)90126-4
   Raabe A, 2004, NEUROL RES, V26, P440, DOI 10.1179/016164104225015958
   Rabie MA, 2014, J AFFECT DISORDERS, V162, P67, DOI 10.1016/j.jad.2014.02.038
   Rasmussen P, 2009, EXP PHYSIOL, V94, P1062, DOI 10.1113/expphysiol.2009.048512
   Ren K, 2010, NAT MED, V16, P1267, DOI 10.1038/nm.2234
   REZNICK AZ, 1994, METHOD ENZYMOL, V233, P357
   Rokyta R, 2003, NEUROENDOCRINOL LETT, V24, P304
   Rossi S, 2009, CLIN NEUROPHYSIOL, V120, P2008, DOI 10.1016/j.clinph.2009.08.016
   Rothwell JC, 1997, J NEUROSCI METH, V74, P113, DOI 10.1016/S0165-0270(97)02242-5
   Rozen T, 2007, HEADACHE, V47, P1050, DOI 10.1111/j.1526-4610.2006.00722.x
   Schaller G, 2014, J NEURAL TRANSM, V121, P307, DOI 10.1007/s00702-013-1102-1
   Shah JP, 2008, J BODYW MOV THER, V12, P371, DOI 10.1016/j.jbmt.2008.06.006
   Sheeran P, 1997, BRIT J ANAESTH, V78, P201, DOI 10.1093/bja/78.2.201
   Short EB, 2011, PAIN, V152, P2477, DOI 10.1016/j.pain.2011.05.033
   Silva JRT, 2011, J PAIN, V12, P51, DOI 10.1016/j.jpain.2010.04.008
   Simkó M, 2007, CURR MED CHEM, V14, P1141, DOI 10.2174/092986707780362835
   Simons DG., 1999, MYOFASCIAL PAIN DYSF, V1
   Simons DG, 2007, J MUSCULOSKELET PAIN, V15, P39
   Spampinato C, 2013, IEEE T NEUR SYS REH, V21, P391, DOI 10.1109/TNSRE.2013.2256432
   Staud R, 2007, BEST PRACT RES CL RH, V21, P581, DOI 10.1016/j.berh.2007.02.013
   Su TF, 2012, EUR J PAIN, V16, P624, DOI 10.1002/j.1532-2149.2011.00055.x
   Taha R, 2012, CAN J ANESTH, V59, P875, DOI 10.1007/s12630-012-9748-y
   Tanure MTA, 2010, J HEADACHE PAIN, V11, P427, DOI 10.1007/s10194-010-0233-0
   Tasset I, 2010, NEUROCHEM RES, V35, P1182, DOI 10.1007/s11064-010-0172-9
   Taves S, 2013, NEURAL PLAST, V2013, DOI 10.1155/2013/753656
   Tian WN, 1999, AM J PHYSIOL-CELL PH, V276, pC1121, DOI 10.1152/ajpcell.1999.276.5.C1121
   Tough EA, 2007, CLIN J PAIN, V23, P278, DOI 10.1097/AJP.0b013e31802fda7c
   Túnez I, 2006, NEUROSCI RES, V56, P91, DOI 10.1016/j.neures.2006.05.012
   Turgut N, 2009, ACTA NEUROL SCAND, V120, P383, DOI 10.1111/j.1600-0404.2009.01235.x
   Vos PE, 2004, NEUROLOGY, V62, P1303, DOI 10.1212/01.WNL.0000120550.00643.DC
   Voti PL, 2011, EXP BRAIN RES, V212, P91, DOI 10.1007/s00221-011-2700-5
   White PF, 2001, ANESTH ANALG, V92, P505, DOI 10.1213/00000539-200102000-00042
   Witt CM, 2009, FORSCH KOMPLEMENTMED, V16, P91, DOI 10.1159/000209315
   Woolf CJ, 2000, SCIENCE, V288, P1765, DOI 10.1126/science.288.5472.1765
   Yap EC, 2007, ANN ACAD MED SINGAP, V36, P43
   Yukimasa T, 2006, PHARMACOPSYCHIATRY, V39, P52, DOI 10.1055/s-2006-931542
   Zanardini R, 2006, J AFFECT DISORDERS, V91, P83, DOI 10.1016/j.jad.2005.12.029
NR 98
TC 24
Z9 27
U1 0
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD JAN
PY 2016
VL 17
IS 1
BP 122
EP 135
DI 10.1111/pme.12919
PG 14
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; General & Internal Medicine
GA DI8DD
UT WOS:000373730500016
PM 26408420
OA Bronze
DA 2026-01-16
ER

PT J
AU Irwin, ML
   Cartmel, B
   Gross, CP
   Ercolano, E
   Li, FY
   Yao, XP
   Fiellin, M
   Capozza, S
   Rothbard, M
   Zhou, Y
   Harrigan, M
   Sanft, T
   Schmitz, K
   Neogi, T
   Hershman, D
   Ligibel, J
AF Irwin, Melinda L.
   Cartmel, Brenda
   Gross, Cary P.
   Ercolano, Elizabeth
   Li, Fangyong
   Yao, Xiaopan
   Fiellin, Martha
   Capozza, Scott
   Rothbard, Marianna
   Zhou, Yang
   Harrigan, Maura
   Sanft, Tara
   Schmitz, Kathryn
   Neogi, Tuhina
   Hershman, Dawn
   Ligibel, Jennifer
TI Randomized Exercise Trial of Aromatase Inhibitor-Induced Arthralgia in
   Breast Cancer Survivors
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID POSTMENOPAUSAL WOMEN; PHYSICAL-ACTIVITY; JOINT SYMPTOMS;
   CLINICAL-PRACTICE; THERAPY; OUTCOMES; ACUPUNCTURE; TAMOXIFEN; PAIN
AB Purpose
   Arthralgia occurs in up to 50% of breast cancer survivors treated with aromatase inhibitors (AIs) and is the most common reason for poor AI adherence. We conducted, in 121 breast cancer survivors receiving an AI and reporting arthralgia, a yearlong randomized trial of the impact of exercise versus usual care on arthralgia severity.
   Patients and Methods
   Eligibility criteria included receiving an AI for at least 6 months, reporting >= 3 of 10 for worst joint pain on the Brief Pain Inventory (BPI), and reporting < 90 minutes per week of aerobic exercise and no strength training. Participants were randomly assigned to exercise (150 minutes per week of aerobic exercise and supervised strength training twice per week) or usual care. The BPI, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, and Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire were completed at baseline and at 3, 6, 9, and 12 months. Intervention effects were evaluated using mixed-model repeated measures analysis, with change at 12 months as the primary end point.
   Results
   Over 12 months, women randomly assigned to exercise (n = 61) attended 70% (+/- standard deviation [SD], 28%) of resistance training sessions and increased their exercise by 159 (+/- SD, 136) minutes per week. Worst joint pain scores decreased by 1.6 points (29%) at 12 months among women randomly assigned to exercise versus a 0.2-point increase (3%) among those receiving usual care (n = 60; P < .001). Pain severity and interference, as well as DASH and WOMAC pain scores, also decreased significantly at 12 months in women randomly assigned to exercise, compared with increases for those receiving usual care (all P < .001).
   Conclusion
   Exercise led to improvement in AI-induced arthralgia in previously inactive breast cancer survivors. (C) 2014 by American Society of Clinical Oncology
C1 [Irwin, Melinda L.; Cartmel, Brenda; Gross, Cary P.; Ercolano, Elizabeth; Li, Fangyong; Yao, Xiaopan; Fiellin, Martha; Capozza, Scott; Rothbard, Marianna; Zhou, Yang; Harrigan, Maura; Sanft, Tara] Yale Univ, New Haven, CT 06520 USA.
   [Irwin, Melinda L.; Cartmel, Brenda; Gross, Cary P.; Ercolano, Elizabeth; Li, Fangyong; Yao, Xiaopan; Zhou, Yang; Sanft, Tara] Yale Canc Ctr, New Haven, CT USA.
   [Schmitz, Kathryn] Univ Penn, Philadelphia, PA 19104 USA.
   [Neogi, Tuhina] Boston Univ, Sch Med, Boston, MA 02118 USA.
   [Ligibel, Jennifer] Dana Farber Canc Inst, Boston, MA 02115 USA.
   [Hershman, Dawn] Columbia Univ, New York, NY USA.
C3 Yale University; Yale University; Yale New Haven Hospital; University of
   Pennsylvania; Boston University; Harvard University; Harvard University
   Medical Affiliates; Dana-Farber Cancer Institute; Columbia University
RP Irwin, ML (corresponding author), Yale Univ, Sch Publ Hlth, Dept Chron Dis Epidemiol, POB 208034, New Haven, CT 06520 USA.
EM melinda.irwin@yale.edu
RI Schmitz, Kathryn H/HOA-7861-2023; Neogi, Tuhina/AAM-1110-2020; Hershman,
   Dawn/AAG-2114-2020
OI Schmitz, Kathryn H/0000-0003-2400-2935; Neogi,
   Tuhina/0000-0002-9515-1711; 
FU National Cancer Institute [R01 CA132931]; Breast Cancer Research
   Foundation; Yale Cancer Center [P30 CA016359]; Clinical and
   Translational Science Award from the National Center for Advancing
   Translational Science, a component of the National Institutes of Health
   [UL1 TR000142]; National Cancer Institute [P30CA016359] Funding Source:
   NIH RePORTER
FX Supported by National Cancer Institute Grant No. R01 CA132931 and in
   part by a grant from the Breast Cancer Research Foundation (M.L.I.),
   Yale Cancer Center Support Grant No. P30 CA016359, and Clinical and
   Translational Science Award Grant No. UL1 TR000142 from the National
   Center for Advancing Translational Science, a component of the National
   Institutes of Health. Certain data used in this study were obtained from
   the Connecticut Tumor Registry, located in the Connecticut Department of
   Public Health. The authors assume full responsibility for analyses and
   interpretation of these data.
CR [Anonymous], 2011, The DASH and QuickDASH Outcome Measure Users Manual
   Ballard-Barbash R, 2012, JNCI-J NATL CANCER I, V104, P815, DOI 10.1093/jnci/djs207
   BELLAMY N, 1988, J RHEUMATOL, V15, P1833
   BLAIR SN, 1985, AM J EPIDEMIOL, V122, P794, DOI 10.1093/oxfordjournals.aje.a114163
   Burstein HJ, 2010, J CLIN ONCOL, V28, P3784, DOI 10.1200/JOP.000082
   Chlebowski RT, 2009, J CLIN ONCOL, V27, P4032, DOI 10.1200/JCO.2009.23.3270
   Church TS, 2007, JAMA-J AM MED ASSOC, V297, P2081, DOI 10.1001/jama.297.19.2081
   Clarke M, 2006, ANN ONCOL, V17, pX59, DOI 10.1093/annonc/mdl238
   Cleeland C. S., 1994, Annals Academy of Medicine Singapore, V23, P129
   Crew KD, 2007, J CLIN ONCOL, V25, P3877, DOI 10.1200/JCO.2007.10.7573
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Fallowfield LJ, 2006, J CLIN ONCOL, V24, P910, DOI 10.1200/JCO.2005.03.3654
   Fitzmaurice GM, 2011, APPL LONGITUDINAL AN, P122
   Galantino ML, 2013, ALTERN THER HEALTH M, V19, P38
   Galantino ML, 2012, INTEGR CANCER THER, V11, P313, DOI 10.1177/1534735411413270
   Gnant M, 2011, BREAST CARE, V6, P136, DOI 10.1159/000328054
   Goss PE, 2003, NEW ENGL J MED, V349, P1793, DOI 10.1056/NEJMoa032312
   Greenlee H, 2013, SUPPORT CARE CANCER, V21, P1077, DOI 10.1007/s00520-012-1628-z
   Hedeker D, 1997, PSYCHOL METHODS, V2, P64, DOI 10.1037/1082-989X.2.1.64
   Henry NL, 2008, BREAST CANCER RES TR, V111, P365, DOI 10.1007/s10549-007-9774-6
   Hershman DL, 2011, BREAST CANCER RES TR, V126, P529, DOI 10.1007/s10549-010-1132-4
   Jones MD, 2014, MED SCI SPORT EXER, V46, P1640, DOI 10.1249/MSS.0000000000000273
   Khan QJ, 2010, BREAST CANCER RES TR, V119, P111, DOI 10.1007/s10549-009-0495-x
   KRISKA AM, 1990, DIABETES CARE, V13, P401, DOI 10.2337/diacare.13.4.401
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   Mao JJ, 2009, CANCER, V115, P3631, DOI 10.1002/cncr.24419
   Murphy CC, 2012, BREAST CANCER RES TR, V134, P459, DOI 10.1007/s10549-012-2114-5
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Peel AB, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.113.000432
   Schmitz KH, 2010, MED SCI SPORT EXER, V42, P1409, DOI 10.1249/MSS.0b013e3181e0c112
   Schmitz KH, 2009, NEW ENGL J MED, V361, P664, DOI 10.1056/NEJMoa0810118
   Sestak I, 2008, LANCET ONCOL, V9, P866, DOI 10.1016/S1470-2045(08)70182-7
   Thomas KS, 2002, BMJ-BRIT MED J, V325, P752, DOI 10.1136/bmj.325.7367.752
NR 33
TC 234
Z9 262
U1 0
U2 50
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD APR 1
PY 2015
VL 33
IS 10
BP 1104
EP 1111
DI 10.1200/JCO.2014.57.1547
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA CK2QZ
UT WOS:000356057900006
PM 25452437
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Zhou, J
   Jin, Y
   Ma, RJ
   Song, HY
   Chen, Q
   Chai, YY
   Liang, Y
   Zhou, Y
   Fang, JQ
AF Zhou, Jie
   Jin, Ying
   Ma, Ruijie
   Song, Hongyun
   Chen, Qin
   Chai, Yueyang
   Liang, Yi
   Zhou, You
   Fang, Jianqiao
TI Electroacupuncture Alleviates Experimental Chronic Inflammatory Pain by
   Inhibiting Calcium Voltage-Gated Channel-Mediated Inflammation
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID DORSAL-ROOT GANGLIA; NEURONAL APOPTOSIS; RNA-SEQ; EXPRESSION ANALYSIS;
   RAT MODEL; INVOLVEMENT; ACTIVATION; HYPERALGESIA; RECEPTORS; ANALGESIA
AB Background. Both experimental and clinical studies have shown that electroacupuncture (EA) administration ameliorates chronic inflammatory pain (CIP). However, the multifaceted mechanism underlying the effects of EA on CIP is poorly understood. In this study, the mRNA transcriptome was used to study various therapeutic targets of EA. Methods. Using RNA-sequencing, protein-coding mRNA expression profiles of the L4-L5 dorsal root ganglion (DRG) were examined in the control (CN), complete Freund's adjuvant- (CFA-) induced CIP, and EA-treated CIP groups. A series of bioinformatics analyses was performed; "EA-reversed upregulated genes with CIP" (up-DEGs) and "EA-reversed downregulated genes with CIP" (down-DEGs) were identified. Thereafter, based on up-DEGs and down-DEGs, biological functions and signaling pathways were enriched using gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway analyses. Results. In total, 189 DEGs were identified, including 134 up- and 55 down-DEGs, which were enriched in arachidonic acid metabolism (rno00590), glutamatergic synapse (rno04724), serotonergic synapse (rno04726), FoxO signaling pathway (rno04068), insulin signaling pathway (rno04910), amyotrophic lateral sclerosis (rno05014), cholinergic synapse (rno04725), ECM-receptor interaction (rno04512), and choline metabolism in cancer (rno05231). Conclusion. We identified a few GOs, pathways, and genes that could play key roles in the amelioration of CIP by EA. Hence, this study may provide a theoretical basis for CIP amelioration by EA.
C1 [Zhou, Jie; Ma, Ruijie; Chen, Qin] Zhejiang Chinese Med Univ, Affiliated Hosp 3, 219 Moganshan Rd, Hangzhou 310005, Zhejiang, Peoples R China.
   [Jin, Ying; Song, Hongyun; Zhou, You] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Rehabil Tradit Chinese Med, 88,JiefangRd, Hangzhou 310000, Zhejiang, Peoples R China.
   [Chai, Yueyang] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Emergency Med, 88,JiefangRd, Hangzhou 310000, Zhejiang, Peoples R China.
   [Liang, Yi] Zhejiang Chinese Med Univ, Clin Med Coll 3, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.
   [Fang, Jianqiao] Zhejiang Chinese Med Univ, Key Lab Acupuncture & Neurol Zhejiang Prov, Clin Med Coll 3, Hangzhou 310053, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang University; Zhejiang
   University; Zhejiang Chinese Medical University; Zhejiang Chinese
   Medical University
RP Fang, JQ (corresponding author), Zhejiang Chinese Med Univ, Key Lab Acupuncture & Neurol Zhejiang Prov, Clin Med Coll 3, Hangzhou 310053, Zhejiang, Peoples R China.
EM fangjianqiao7532@163.com
OI Fang, Jianqiao/0000-0002-5155-8544; Jin, Ying/0000-0001-9731-2307; Zhou,
   Jie/0000-0002-1436-0969
FU Natural Science Foundation of Zhejiang Province [LQ18H270001];
   Innovation Fund for Youth of Zhejiang Chinese Medical University
   [KC201947]
FX The authors are grateful to Mr. Qiang Fan (Ao Ji Bio-tech Co., Ltd,
   Shanghai, China) for providing help in data analysis. This work was
   supported by the Natural Science Foundation of Zhejiang Province
   (LQ18H270001) and Innovation Fund for Youth of Zhejiang Chinese Medical
   University (KC201947).
CR Alvarez-Garcia O, 2018, AGING CELL, V17, DOI 10.1111/acel.12800
   [Anonymous], EVIDENCE BASED COMPL
   Ashburner M, 2000, NAT GENET, V25, P25, DOI 10.1038/75556
   Borghi SM, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1496-2
   Fang JQ, 2013, EUR J INFLAMM, V11, P375, DOI 10.1177/1721727X1301100208
   Fang JQ, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-285
   Fang JQ, 2013, MOL PAIN, V9, DOI 10.1186/1744-8069-9-13
   Ferreira ML, 2017, BEST PRACT RES CL RH, V31, P192, DOI 10.1016/j.berh.2017.08.006
   Gagliese L, 2018, PROG NEURO-PSYCHOPH, V87, P207, DOI 10.1016/j.pnpbp.2017.09.022
   Han JS, 2011, PAIN, V152, pS41, DOI 10.1016/j.pain.2010.10.012
   Hu F, 2019, FASEB J, V33, P668, DOI 10.1096/fj.201800382RR
   Jackson T, 2016, ANESTH ANALG, V123, P739, DOI 10.1213/ANE.0000000000001389
   Ji RR, 1995, J NEUROSCI, V15, P8156
   Kim D, 2015, NAT METHODS, V12, P357, DOI [10.1038/NMETH.3317, 10.1038/nmeth.3317]
   Mao JR, 2002, J NEUROSCI, V22, P7650
   Matsubara T, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1155/2011/543291
   Mi WL, 2008, BRAIN RES BULL, V77, P98, DOI 10.1016/j.brainresbull.2008.04.008
   Mi WL, 2011, J PAIN, V12, P974, DOI 10.1016/j.jpain.2011.03.002
   Mortazavi A, 2008, NAT METHODS, V5, P621, DOI 10.1038/nmeth.1226
   Nikolayeva O, 2014, METHODS MOL BIOL, V1150, P45, DOI 10.1007/978-1-4939-0512-6_3
   Pertea M, 2016, NAT PROTOC, V11, P1650, DOI 10.1038/nprot.2016.095
   Pertea M, 2015, NAT BIOTECHNOL, V33, P290, DOI 10.1038/nbt.3122
   Robinson MD, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-3-r25
   Robinson MD, 2010, BIOINFORMATICS, V26, P139, DOI 10.1093/bioinformatics/btp616
   Scholz J, 2005, J NEUROSCI, V25, P7317, DOI 10.1523/JNEUROSCI.1526-05.2005
   Shan S, 2007, NEUROBIOL DIS, V26, P558, DOI 10.1016/j.nbd.2007.02.007
   Wang DM, 2015, J PHARMACOL EXP THER, V354, P431, DOI 10.1124/jpet.115.225672
   Wang F, 2018, BLOOD, V131, P2929, DOI 10.1182/blood-2017-10-813576
   Wang JY, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/8403064
   Wu GW, 2019, CHIN J INTEGR MED, V25, P677, DOI 10.1007/s11655-018-2916-8
   Xu Y, 2018, AM J CHINESE MED, V46, P997, DOI 10.1142/S0192415X18500520
   Yu GC, 2012, OMICS, V16, P284, DOI 10.1089/omi.2011.0118
   Zhao XY, 2019, SCI TOTAL ENVIRON, V646, P1047, DOI 10.1016/j.scitotenv.2018.07.363
NR 33
TC 7
Z9 9
U1 2
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD FEB 10
PY 2020
VL 2020
AR 7061972
DI 10.1155/2020/7061972
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA LD5YY
UT WOS:000526107500001
PM 32104194
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Silva, JG
   Santana, CG
   Inocêncio, KR
   Orsini, M
   Machado, S
   Bergmann, A
AF Silva, Julio Guilherme
   Santana, Camila Goncalves
   Inocencio, Kelly Rosane
   Orsini, Marco
   Machado, Sergio
   Bergmann, Anke
TI Electrocortical Analysis of Patients with Intercostobrachial Pain
   Treated with TENS after Breast Cancer Surgery
SO JOURNAL OF PHYSICAL THERAPY SCIENCE
LA English
DT Article
DE Transcutaneous electric nerve stimulation; Mastectomy;
   Electroencephalography
ID ELECTRICAL NERVE-STIMULATION; HIGH-FREQUENCY; EEG ALPHA; ATTENTION;
   CORTEX; POWER
AB [Purpose] Among the physical therapeutic procedures to decrease pain, there is transcutaneous electrical neural stimulation (TENS). There is no consensus about its efficacy for oncological patients, especially for post-mastectomy pain and eletrocortical changes in somatosensory areas. The aim of this study was to analyze acute electrocortical changes after TENS treatment of patients with intercostobrachial post mastectomy pain. [Subjects] Eighteen patients were divided into acupuncture (A) and burst (B) group. [Methods] In this pre and post-intervention study each group was measured for EEG analysis in absulte power in alpha band (8-14 Hz). Outcomes variables were the alpha waveband in the sensorymotor cortex and pain pre-and-post TENS intervention. Data were analyzed using ANOVA to compare times (rest, 10 and 15 min), group and electrodes. Pain was analyzed using percentual pain evaluation (PPE) in both groups. [Results] Outcomes indicate main effects of time and electrodes because of slow (8-10 Hz) and fast alpha (10-12 Hz) wavebands decreased. PPE reduced 88.4% in A and 66.3% in G. [Conclusion] TENS promoted electrical modification in the parietal region and a decrease in pain. Future studies should investigate other wave must be proposed for other bands and use different methods of EEG analysis to elucidate the actual mechanisms behind the efficacy of TENS treatment.
C1 [Silva, Julio Guilherme; Orsini, Marco] Fed Univ Rio de Janeiro UFRJ, Dept Phys Therapy, Rio De Janeiro, Brazil.
   [Silva, Julio Guilherme; Santana, Camila Goncalves; Bergmann, Anke] Augusto Motta Univ Ctr UNISUAM, Rehabil Sci Masters Program, BR-21041021 Rio De Janeiro, Brazil.
   [Machado, Sergio] Fed Univ Rio de Janeiro UFRJ, Pan & Respirat Lab, Inst Psychiat, Rio De Janeiro, Brazil.
   [Machado, Sergio] Cent Univ, Quiropraxia Program, Santiago, Chile.
C3 Universidade Federal do Rio de Janeiro; Centro Universitario Augusto
   Motta (UNISUAM); Universidade Federal do Rio de Janeiro; Universidad
   Central de Chile
RP Silva, JG (corresponding author), Fed Univ Rio de Janeiro UFRJ, Dept Phys Therapy, Rio De Janeiro, Brazil.
EM jgl-silva@yahoo.com.br
RI Machado, Sergio/M-9384-2013; Bergmann, Anke/G-2684-2012; Silva,
   Julio/T-3582-2018
OI Machado, Sergio/0000-0001-8946-8467; 
CR Bevilacqua JLB, 2012, ANN SURG ONCOL, V19, P2580, DOI 10.1245/s10434-012-2290-x
   Cameroon M, 2008, AGENTES FISICOS REAB
   Domingues CA, 2008, ARQ NEURO-PSIQUIAT, V66, P336, DOI 10.1590/S0004-282X2008000300010
   Dong WK, 1995, FRONTIER PAIN RES, P183
   Downian R, 2008, CLIN NEUROPHYSIOL, V119, P1201, DOI 10.1016/j.clinph.2008.01.019
   Foxe JJ, 1998, NEUROREPORT, V9, P3929, DOI 10.1097/00001756-199812010-00030
   Frot M, 2001, PAIN, V94, P65, DOI 10.1016/S0304-3959(01)00342-6
   Hurlow A, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006276.pub3
   Jung BF, 2003, PAIN, V104, P1, DOI 10.1016/S0304-3959(03)00241-0
   Klimesch W, 1998, NEUROSCI LETT, V244, P73, DOI 10.1016/S0304-3940(98)00122-0
   Klimesch W, 1999, BRAIN RES REV, V29, P169, DOI 10.1016/S0165-0173(98)00056-3
   Léonard G, 2011, J PAIN, V12, P213, DOI 10.1016/j.jpain.2010.07.003
   Leonard G, 2010, PAIN, V151, P215, DOI 10.1016/j.pain.2010.07.012
   Liebano RE, 2011, PAIN, V152, P335, DOI 10.1016/j.pain.2010.10.040
   Ministerio de Agricultura Alimentacion y Medio Ambiente, 2012, ENC SUP REND CULT ES, P1
   NEIDERMEYER E, 1999, ELECTROENCEPHALOGRAP
   Fabro EAN, 2012, BREAST, V21, P321, DOI 10.1016/j.breast.2012.01.019
   Pena R., 2008, Revista Brasileira de Cancerologia, V54, P193, DOI DOI 10.32635/2176-9745.RBC.2008V54N2.1750
   Rakel B, 2003, J PAIN, V4, P455, DOI 10.1067/S1526-5900(03)00780-6
   Robb K, 2009, J PAIN SYMPTOM MANAG, V37, P746, DOI 10.1016/j.jpainsymman.2008.03.022
   Robb KA, 2007, J PAIN SYMPTOM MANAG, V33, P410, DOI 10.1016/j.jpainsymman.2006.09.020
   Sampaio LR, 2005, REV BRAS CANCEROL, V51, P339, DOI [10.32635/2176-9745.RBC.2005v51n4.1940, DOI 10.32635/2176-9745.RBC.2005V51N4.1940]
   Sauseng P, 2005, EUR J NEUROSCI, V22, P2917, DOI 10.1111/j.1460-9568.2005.04482.x
   Silva JG, 2006, ARQ NEURO-PSIQUIAT, V64, P473, DOI 10.1590/S0004-282X2006000300023
   Sluka KA, 2005, J NEUROCHEM, V95, P1794, DOI 10.1111/j.1471-4159.2005.03511.x
   Thatcher RW, 2005, CLIN EEG NEUROSCI, V36, P116, DOI 10.1177/155005940503600211
   Thut G, 2006, J NEUROSCI, V26, P9494, DOI 10.1523/JNEUROSCI.0875-06.2006
   Tiezzi DG, 2009, REV BRAS GINECOL OBS, V31, P213, DOI 10.1590/S0100-72032009000500001
   Worden MS, 2000, J NEUROSCI, V20
NR 29
TC 22
Z9 27
U1 0
U2 13
PU SOC PHYSICAL THERAPY SCIENCE
PI TOKYO
PA C/O PUBLICATION CENTER, 1-24-12 SUGAMO, TOSHIMA-KU, TOKYO, 170-0002,
   JAPAN
SN 0915-5287
EI 2187-5626
J9 J PHYS THER SCI
JI J. Phys. Ther. Sci.
PD MAR
PY 2014
VL 26
IS 3
BP 349
EP 353
DI 10.1589/jpts.26.349
PG 5
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA AM1QA
UT WOS:000339621300006
PM 24707082
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Hamachi, A
   Matriz, J
   Fukui, J
AF Hamachi, April
   Matriz, Jobel
   Fukui, Jami
TI The use of complementary and alternative medicine among cancer patients
   in Hawaii
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE CAM; Complementary; Alternative; Integrative medicine; Cancer symptom
   management
ID BREAST-CANCER; WOMEN
AB Complementary and alternative medicine (CAM) are medical products and practices that are not part of standard medical care. Various studies demonstrate benefits of CAM use in alleviating cancer related side effects. However, data involving the use of CAM therapies among cancer patients is limited. Hawaii has a unique and diverse population and trends in CAM use could reveal important aspects of cancer care.We distributed questionnaires to various cancer treatment centers across Oahu. The questionnaires were optional and anonymous. We evaluated 126 questionnaires and analyzed CAM use. We collected participant data including: cancer type, treatments used (surgery, radiation, chemotherapy) and patient demographics (age, gender, ethnicity, income, religion).We found that at least one CAM therapy is used by a majority of patients 72/126 (57.1%), while 54 (42.9%) do not use any CAM therapy. Among the CAM therapies, meditation and herbal supplements were most commonly used 26 (36.1%), followed by massage 25 (34.7%), yoga 18 (25%), CBD 17 (23.6%), THC 16 (22.2%), and acupuncture 14 (19.4%). Stress reduction was the most common symptom benefit noted for meditation, herbal supplement, massage, and yoga. Anxiety was another symptom benefit reported for meditation. THC and CBD are used for sleep, however, CBS was also used for pain reduction together with acupuncture. Among the patients who use CAM therapy (n = 72), 80.6% are female (n = 58) while only 8.3% are male (n = 6). Furthermore only, 18.3% (n = 23) of our respondents have spoken to a clinician about CAM.We discovered that stress reduction is a symptom benefit associated with the most commonly used CAM therapies by cancer patients in Hawaii. Other symptom benefits involve anxiety, pain, and sleep. The modalities utilized were similar to nonpharmacologic therapies recommended by the NCCN guidelines for cancer survivorship, with the exception of herbal supplements. There is a lack of physician discussion regarding CAM use, which could impact the cancer burden in Hawaii.
C1 [Hamachi, April; Matriz, Jobel] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA.
   [Fukui, Jami] Univ Hawaii, Canc Ctr, Honolulu, HI USA.
C3 University of Hawaii System; Cancer Research Center of Hawaii;
   University of Hawaii System
RP Hamachi, A (corresponding author), Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA.
EM ahamachi@hawaii.edu
FU University of Hawaii Cancer Center [P30 CA071789-18]
FX The study was supported by the University of Hawaii Cancer Center P30
   CA071789-18 support grant.
CR AARP/NCCAM, 2007, Consumer Survey Report
   Bennett JA, 2009, J GEN INTERN MED, V24, P1089, DOI 10.1007/s11606-009-0979-8
   Complementary and Alternative Medicine (CAM), 1980, NCI
   Fukui Jami, 2021, J Psychosoc Oncol Res Pract, V3, DOI [10.1097/or9.0000000000000055, 10.1097/or9.0000000000000055]
   Harrigan Rosanne, 2006, Hawaii Med J, V65, P130
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hierl M, 2017, ONCOLOGY-BASEL, V93, P157, DOI 10.1159/000464248
   Horneber M, 2012, INTEGR CANCER THER, V11, P187, DOI 10.1177/1534735411423920
   Källman M, 2023, BMC COMPLEMENT MED, V23, DOI 10.1186/s12906-023-03876-2
   Kim Min Jae, 2004, Korean Journal of Internal Medicine, V19, P250
   Krogstad J.M., 2015, Hawaii is home to the nation's largest share of multiracial Americans
   Kwon JH, 2019, CANCER RES TREAT, V51, P851, DOI 10.4143/crt.2019.137
   Metin ZG, 2019, EUR J ONCOL NURS, V42, P116, DOI 10.1016/j.ejon.2019.09.003
   Oneha Mary Frances, 2023, Hawaii J Health Soc Welf, V82, P72
   Sanford NN, 2019, JAMA ONCOL, V5, P735, DOI 10.1001/jamaoncol.2019.0349
   Taso CJ, 2014, J NURS RES, V22, P155, DOI 10.1097/jnr.0000000000000044
   Wolf CPJG, 2022, J CANCER RES CLIN, V148, P461, DOI 10.1007/s00432-021-03625-3
   Wu A, 2023, JCO GLOB ONCOL, V9, DOI 10.1200/GO.22.00303
NR 18
TC 0
Z9 0
U1 6
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD MAY 8
PY 2025
VL 25
IS 1
AR 167
DI 10.1186/s12906-025-04912-z
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 2KY4L
UT WOS:001485122000001
PM 40340689
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Kwekkeboom, KL
AF Kwekkeboom, Kristine L.
TI CANCER SYMPTOM CLUSTER MANAGEMENT
SO SEMINARS IN ONCOLOGY NURSING
LA English
DT Article
DE symptom cluster; symptom management; clinical practice; therapeutics;
   patient education
ID RANDOMIZED CONTROLLED-TRIAL; COGNITIVE-BEHAVIORAL INTERVENTION;
   QUALITY-OF-LIFE; BREAST-CANCER; PALLIATIVE CARE; LUNG-CANCER; WOMEN;
   DISTRESS; THERAPY; FATIGUE
AB OBJECTIVES: To discuss the importance of cancer symptom clusters in clinical practice, review evidence for symptom cluster interventions, and make recommendations for symptom cluster identification, patient education, and management in clinical practice.
   DATA SOURCES: Primary research and review articles identified through CINAHL, PubMed, and PsycINFO databases.
   CONCLUSION: Several studies have investigated interventions for multi-symptom management or have evaluated the secondary effects of a single-symptom intervention on related symptoms. To date, only five studies have tested an intervention designed to manage a specific cancer symptom cluster. Those studies used nonpharmacologic approaches (psycho-education, cognitive-behavioral strategies, and acupressure) to address the pain, fatigue, and sleep disturbance symptom cluster, or the respiratory distress symptom cluster with some initial evidence of success. Further development and efficacy testing of symptom cluster interventions is needed.
   IMPLICATIONS FOR NURSING PRACTICE: Clinical practice can be guided by knowledge of individual and multi-symptom management, and clinical judgment regarding possible etiologies of cancer symptom clusters. Clinicians should be aware of co-occurring symptoms in their patients, educate and involve patients in identifying symptom clusters and aggravating/alleviating factors, and coordinate treatment recommendations using strategies that are likely to be beneficial across symptoms.
C1 [Kwekkeboom, Kristine L.] Univ Wisconsin Madison, Sch Nursing, Signe Skott Cooper Hall,Suite 3137,701 Highland A, Madison, WI 53705 USA.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Kwekkeboom, KL (corresponding author), Univ Wisconsin Madison, Sch Nursing, Signe Skott Cooper Hall,Suite 3137,701 Highland A, Madison, WI 53705 USA.
EM kwekkeboom@wisc.edu
OI Kwekkeboom, Kristine/0000-0003-2459-0896
FU National Institute of Nursing Research of the National Institutes of
   Health [R01NR013468]
FX This publication was made possible by grant no. R01NR013468 (Kwekkeboom,
   PI) from the National Institute of Nursing Research of the National
   Institutes of Health. The content is solely the responsibility of the
   author and does not necessarily represent the official views of the
   National Institutes of Health.
CR Aktas A, 2012, SUPPORT CARE CANCER, V20, P2837, DOI 10.1007/s00520-012-1408-9
   Al-Dasooqi N, 2013, SUPPORT CARE CANCER, V21, P3233, DOI 10.1007/s00520-013-1900-x
   American Cancer Society, GETT HELP FAT
   Bakitas M, 2009, JAMA-J AM MED ASSOC, V302, P741, DOI 10.1001/jama.2009.1198
   Barsevick A, 2010, J PAIN SYMPTOM MANAG, V40, P200, DOI 10.1016/j.jpainsymman.2009.12.020
   Barsevick AM, 2007, ONCOL NURS FORUM, V34, P971, DOI 10.1188/07.ONF.971-980
   Berger AM, 2009, PSYCHO-ONCOLOGY, V18, P634, DOI 10.1002/pon.1438
   Carpenter J.S., 2007, ONCOL NURS FORUM, V34, pE1, DOI DOI 10.1188/07.ONF.E1-E8
   Chan CWH, 2011, J PAIN SYMPTOM MANAG, V41, P347, DOI 10.1016/j.jpainsymman.2010.04.024
   Chang VT, 2000, CANCER-AM CANCER SOC, V88, P1175, DOI 10.1002/(SICI)1097-0142(20000301)88:5<1175::AID-CNCR30>3.0.CO;2-N
   Cherwin CH, 2012, ONCOL NURS FORUM, V39, P157, DOI 10.1188/12.ONF.157-165
   Coolbrandt A, 2014, INT J NURS STUD, V51, P495, DOI 10.1016/j.ijnurstu.2013.08.008
   Dodd M, 2001, J ADV NURS, V33, P668, DOI 10.1046/j.1365-2648.2001.01697.x
   Dodd M J, 2001, Oncol Nurs Forum, V28, P465
   Dong ST, 2014, J PAIN SYMPTOM MANAG, V48, P411, DOI 10.1016/j.jpainsymman.2013.10.027
   Donovan HS, 2014, J PAIN SYMPTOM MANAG, V47, P218, DOI 10.1016/j.jpainsymman.2013.04.005
   Doong SH, 2015, BIOL RES NURS, V17, P237, DOI 10.1177/1099800414550394
   Ellis J, 2012, J PAIN SYMPTOM MANAG, V44, P831, DOI 10.1016/j.jpainsymman.2011.12.274
   Erickson JM, 2013, INT J NURS STUD, V50, P847, DOI 10.1016/j.ijnurstu.2012.10.011
   Fenlon DR, 2008, J PAIN SYMPTOM MANAG, V35, P397, DOI 10.1016/j.jpainsymman.2007.05.014
   Fleming L, 2014, PSYCHO-ONCOLOGY, V23, P679, DOI 10.1002/pon.3468
   Freeman LW, 2015, PSYCHO-ONCOLOGY, V24, P910, DOI 10.1002/pon.3656
   Given C, 2004, J CLIN ONCOL, V22, P507, DOI 10.1200/JCO.2004.01.241
   Heidrich SM, 2009, ONCOL NURS FORUM, V36, pE133, DOI 10.1188/09.ONF.E133-E143
   Jarden M, 2009, J PAIN SYMPTOM MANAG, V38, P174, DOI 10.1016/j.jpainsymman.2008.09.005
   Jiménez A, 2011, J PAIN SYMPTOM MANAG, V42, P24, DOI 10.1016/j.jpainsymman.2010.10.266
   Johnson J., 1997, SELF REGULATION THEO
   Kao CY, 2014, INT J NURS STUD, V51, P226, DOI 10.1016/j.ijnurstu.2013.05.008
   Kim Hee-Ju, 2012, Oncol Nurs Forum, V39, pE20, DOI 10.1188/12.ONF.E20-E30
   Kim HJ, 2005, CANCER NURS, V28, P270
   Kirkova J, 2011, J PALLIAT MED, V14, P1149, DOI 10.1089/jpm.2010.0507
   Kirkova J, 2010, AM J HOSP PALLIAT ME, V27, P342, DOI 10.1177/1049909110369869
   Knobf MT, 2014, CANCER NURS, V37, pE43, DOI 10.1097/NCC.0b013e318288d40e
   Kwekkeboom KL, 2012, J PAIN SYMPTOM MANAG, V44, P810, DOI 10.1016/j.jpainsymman.2011.12.281
   Kwekkeboom Kristine L, 2010, Oncol Nurs Forum, V37, pE151, DOI 10.1188/10.ONF.E151-E159
   Lacasse Cheryl, 2007, Semin Oncol Nurs, V23, P106, DOI 10.1016/j.soncn.2007.01.007
   Lee TI, 2006, AM J CHINESE MED, V34, P37, DOI 10.1142/S0192415X06003618
   Lengacher CA, 2012, J BEHAV MED, V35, P86, DOI 10.1007/s10865-011-9346-4
   Matthews EE, 2014, ONCOL NURS FORUM, V41, P241, DOI 10.1188/14.ONF.41-03AP
   McMillan SC, 2007, ONCOL NURS FORUM, V34, P313, DOI 10.1188/07.ONF.313-321
   Molassiotis A, 2010, J PAIN SYMPTOM MANAG, V39, P847, DOI 10.1016/j.jpainsymman.2009.09.012
   National Cancer Institute, PAIN CONTR SUPP PEOP
   PORTENOY RK, 1994, QUAL LIFE RES, V3, P183, DOI 10.1007/BF00435383
   Redd WH, 2001, JNCI-J NATL CANCER I, V93, P810, DOI 10.1093/jnci/93.11.810
   Ruland CM, 2013, CANCER NURS, V36, P6, DOI 10.1097/NCC.0b013e31824d90d4
   Schneider SM, 2007, ONCOL NURS FORUM, V34, P39, DOI 10.1188/07.ONF.39-46
   Schofield P, 2013, PSYCHO-ONCOLOGY, V22, P2445, DOI 10.1002/pon.3306
   Sturgeon M, 2009, J ALTERN COMPLEM MED, V15, P373, DOI 10.1089/acm.2008.0399
   Tassinari D, 2016, REV RECENT CLIN TRIA, V11, P63, DOI 10.2174/1574887110666151014141650
   Temel JS, 2010, NEW ENGL J MED, V363, P733, DOI 10.1056/NEJMoa1000678
   Thomas BC, 2014, J PAIN SYMPTOM MANAG, V47, P566, DOI 10.1016/j.jpainsymman.2013.04.007
   Thornton LM, 2010, HEALTH PSYCHOL, V29, P333, DOI 10.1037/a0018836
   Wagland R, 2012, SUPPORT CARE CANCER, V20, P2565, DOI 10.1007/s00520-011-1362-y
   Williams Loretta A, 2007, Semin Oncol Nurs, V23, P113, DOI 10.1016/j.soncn.2007.01.006
   Wood LJ, 2013, CURR OPIN SUPPORT PA, V7, P54, DOI 10.1097/SPC.0b013e32835dabe3
   Yang CY, 2011, J ADV NURS, V67, P158, DOI 10.1111/j.1365-2648.2010.05492.x
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Yorke J, 2015, SUPPORT CARE CANCER, V23, P3373, DOI 10.1007/s00520-015-2810-x
NR 58
TC 132
Z9 151
U1 6
U2 77
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0749-2081
EI 1878-3449
J9 SEMIN ONCOL NURS
JI Semin. Oncol. Nurs.
PD NOV
PY 2016
VL 32
IS 4
BP 373
EP 382
DI 10.1016/j.soncn.2016.08.004
PG 10
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA FR0XU
UT WOS:000418788700005
PM 27789073
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Zhao, FY
   Zhang, WD
   Chow, CM
   Xu, PJ
   Yue, LP
   Ho, YS
   Fu, QQ
   Conduit, R
AF Zhao, Fei-Yi
   Zhang, Wen-Ding
   Chow, Chin Moi
   Xu, Peijie
   Yue, Li-Ping
   Ho, Yuen-Shan
   Fu, Qiang-Qiang
   Conduit, Russell
TI From Needles to Photons: Clinical Efficacy, Safety, and Mechanistic
   Insights of Laser Acupuncture in Insomnia Management
SO NATURE AND SCIENCE OF SLEEP
LA English
DT Article
DE traditional Chinese medicine; non-pharmacological treatment; auricular
   therapy; auriculotherapy; sleep disorder; sleep disturbance
ID QUALITY-OF-LIFE; SLEEP; RISK; PAIN; COMPLEMENTARY; SYMPTOMS; THERAPY;
   ANXIETY
AB Insomnia constitutes a significant worldwide public health burden. Limitations of conventional treatments, such as cognitive-behavioral therapy and hypnotic medications, have fueled growing interest in complementary and alternative medicine approaches, including laser acupuncture (LA). This comprehensive mini-review evaluates LA's effects and mechanisms for insomnia management. Clinical evidence indicates that LA alleviates both primary insomnia and comorbid cases (eg, with cancer, hypertension, and perimenopausal syndrome). LA demonstrates efficacy comparable to traditional needle acupuncture in improving subjective and objective sleep quality, while also reducing affective symptoms and enhancing quality of life. This provides an appealing alternative for needle-phobia patients. LA appears generally safe, with only mild, transient adverse effects reported. Mechanistic investigations suggest that LA may act via neurotransmitter modulation, autonomic nervous system regulation, and alterations in brain wave activity. reporting, and insufficient follow-ups -- compromise the current evidence base. Future research should adopt multicenter, large-scale, placebo-controlled randomized trials, complemented by advanced techniques such as neuroimaging, polysomnography, and neurochemical assays, to further validate the therapeutic potential of LA and elucidate its underlying mechanisms.
C1 [Zhao, Fei-Yi; Yue, Li-Ping] Shanghai Sanda Univ, Sch Int Med Technol, Dept Nursing, Shanghai 201209, Peoples R China.
   [Zhao, Fei-Yi; Conduit, Russell] RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Vic 3083, Australia.
   [Zhao, Fei-Yi; Chow, Chin Moi] Univ Sydney, Fac Med & Hlth, Sydney Sch Hlth Sci, Camperdown, NSW 2050, Australia.
   [Zhao, Fei-Yi; Zhang, Wen-Ding] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China.
   [Chow, Chin Moi] Univ Sydney, Charles Perkins Ctr, Sleep Res Grp, Camperdown, NSW 2050, Australia.
   [Xu, Peijie] RMIT Univ, Sch Comp Technol, Melbourne, Vic 3000, Australia.
   [Ho, Yuen-Shan] Hong Kong Polytech Univ, Fac Hlth & Social Sci, Sch Nursing, Hong Kong, Peoples R China.
   [Fu, Qiang-Qiang] Tongji Univ, Yangpu Hosp, Sch Med, Shanghai 200090, Peoples R China.
C3 Sanda University; Royal Melbourne Institute of Technology (RMIT);
   University of Sydney; Shanghai University of Traditional Chinese
   Medicine; University of Sydney; Royal Melbourne Institute of Technology
   (RMIT); Hong Kong Polytechnic University; Tongji University
RP Ho, YS (corresponding author), Hong Kong Polytech Univ, Fac Hlth & Social Sci, Sch Nursing, Hong Kong, Peoples R China.; Fu, QQ (corresponding author), Tongji Univ, Yangpu Hosp, Sch Med, Shanghai 200090, Peoples R China.
EM janice.ys.ho@polyu.edu.hk; qiangqiang.fu@tongji.edu.cn
OI Zhao, Fei-Yi/0000-0001-9009-8870; Fu, Qiangqiang/0000-0002-2369-1508;
   Conduit, Russell/0000-0001-9356-6844
FU Scientific Research Fund Project of Shanghai Sanda University
   [2024BSZX03]
FX Funding This work was supported by the Scientific Research Fund Project
   of Shanghai Sanda University [2024BSZX03] to FY-Z.
CR Baxter GD, 2008, J ACUPUNCT MERIDIAN, V1, P65, DOI 10.1016/S2005-2901(09)60026-1
   Benjafield AV, 2025, SLEEP MED REV, V82, DOI 10.1016/j.smrv.2025.102121
   Bolge SC, 2009, QUAL LIFE RES, V18, P415, DOI 10.1007/s11136-009-9462-6
   Chang YP, 2024, LASER MED SCI, V39, DOI 10.1007/s10103-024-04114-y
   Chaput JP, 2023, SLEEP HEALTH, V9, P185, DOI 10.1016/j.sleh.2022.09.010
   Chen CK, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/8136967
   Chilcott LA, 1996, PHARMACOECONOMICS, V10, P1, DOI 10.2165/00019053-199600101-00003
   Chokroverty S, 2010, INDIAN J MED RES, V131, P126
   Chon TY, 2019, MED ACUPUNCT, V31, P164, DOI 10.1089/acu.2019.1343
   Ciano C, 2017, JOGNN-J OBST GYN NEO, V46, P804, DOI 10.1016/j.jogn.2017.07.011
   de Freitas LF, 2016, IEEE J SEL TOP QUANT, V22, DOI 10.1109/JSTQE.2016.2561201
   Dong XY, 2023, J Med Theory Pract, V36, P3762
   Feng SL, 2018, Shandong J Trad Chin Med, V37, P494
   Geiger-Brown JM, 2015, SLEEP MED REV, V23, P54, DOI 10.1016/j.smrv.2014.11.007
   Grandner MA, 2012, J SLEEP RES, V21, P427, DOI 10.1111/j.1365-2869.2011.00990.x
   Grimaldi D, 2021, SLEEP, V44, DOI 10.1093/sleep/zsaa274
   Hettinga DM, 2008, PHYSIOTHERAPY, V94, P97, DOI 10.1016/j.physio.2007.10.008
   Irwin M, 2003, BRAIN BEHAV IMMUN, V17, P365, DOI 10.1016/S0889-1591(03)00031-X
   Jansson-Fröjmark M, 2008, J PSYCHOSOM RES, V64, P443, DOI 10.1016/j.jpsychores.2007.10.016
   Jieun Jung, 2025, sleep medicine research, V15, P218, DOI [10.17241/smr.2024.02593, 10.17241/smr.2024.02593]
   Karia Sagar B, 2016, Ind Psychiatry J, V25, P155, DOI [10.4103/ipj.ipj_86_15, 10.4103/ipj.ipj_86_15]
   Kyle SD, 2010, BEHAV SLEEP MED, V8, P123, DOI 10.1080/15402002.2010.487450
   Lan KC, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/8997051
   Law D, 2015, J ACUPUNCT MERIDIAN, V8, P2
   Leung AK, 2015, Clinical study on laser acupoint therapy for treating insomnia with Yin deficiency with effulgent Fire Master
   Liang GY, 2006, Chin J Pract Med, V5, P648
   Lin JG, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/740508
   Liu T, 2007, EVID-BASED COMPL ALT, V4, P3, DOI 10.1093/ecam/nel061
   Liu WL, 2025, NAT SCI SLEEP, V17, P947, DOI 10.2147/NSS.S501619
   Miglis MG, 2016, SLEEP MED, V19, P40, DOI 10.1016/j.sleep.2015.10.001
   Mira PCD, 2024, LASER MED SCI, V39, DOI 10.1007/s10103-024-03999-z
   Monti Jaime M., 2004, Current Medicinal Chemistry - Central Nervous System Agents, V4, P119, DOI 10.2174/1568015043357039
   Moreno Claudia R C, 2025, Handb Clin Neurol, V206, P89, DOI 10.1016/B978-0-323-90918-1.00015-0
   Moskvin SV, 2020, J LASERS MED SCI, V11, P381, DOI 10.34172/jlms.2020.61
   Naeser MA, 2002, ARCH PHYS MED REHAB, V83, P978, DOI 10.1053/apmr.2002.33096
   Namazi N, 2017, ACUPUNCT MED, V35, P452, DOI 10.1136/acupmed-2017-011401
   Neckelmann D, 2007, SLEEP, V30, P873, DOI 10.1093/sleep/30.7.873
   Neubauer DN, 2018, J CENT NERV SYST DIS, V10, DOI 10.1177/1179573518770672
   Oishi Y, 2017, BRAIN STRUCT FUNCT, V222, P2907, DOI 10.1007/s00429-017-1365-7
   Page JM, 2025, PSYCHO-ONCOLOGY, V34, DOI 10.1002/pon.70079
   Patel D, 2018, J CLIN SLEEP MED, V14, P1017, DOI 10.5664/jcsm.7172
   Pearson NJ, 2006, ARCH INTERN MED, V166, P1775, DOI 10.1001/archinte.166.16.1775
   Sarris J, 2011, SLEEP MED REV, V15, P99, DOI 10.1016/j.smrv.2010.04.001
   Sheppard N, 2022, J SLEEP RES, V31, DOI 10.1111/jsr.13677
   Sterne J., 2019, BMJ, V366, P14898, DOI [10.1136/bmj.l4898, DOI 10.1136/BMJ.L4898]
   Sterne JAC, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i4919
   Suen LKP, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/3651268
   Ton G, 2022, MED ACUPUNCT, V34, P228, DOI 10.1089/acu.2022.0002
   Wang Y, 2015, Liaoning J Tradit Chin Med, V42, P1087
   Wang Y, 2016, Henan Traditional Chin Med, V36, P1258
   Whittaker P, 2004, LASER MED SCI, V19, P69, DOI 10.1007/s10103-004-0296-8
   Winsper C, 2014, INT REV PSYCHIATR, V26, P189, DOI 10.3109/09540261.2014.881330
   Wu JH, 2009, PHOTOMED LASER SURG, V27, P273, DOI 10.1089/pho.2007.2235
   Wu SY, 2017, J Chin Med, V28
   Yang J, 2020, MED ACUPUNCT, V32, P209, DOI 10.1089/acu.2020.1419
   Zhang L, 2018, J Shaanxi Univ Tradit Chin Med, V41, P53
   Zhang Xuejiao, 2024, J Clin Sleep Med, V20, P1975, DOI [10.5664/jcsm.11326, 10.5664/jcsm.11326]
   Zhao FY, 2025, WORLD J PSYCHIATR, V15, DOI 10.5498/wjp.v15.i5.105802
   Zhao FY, 2024, SLEEP MED REV, V74, DOI 10.1016/j.smrv.2023.101892
   Zhao FY, 2021, SLEEP MED, V80, P244, DOI 10.1016/j.sleep.2021.01.053
   Zhou P, 2012, Chin J Clin Healthc, V15, P50
NR 61
TC 0
Z9 0
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1608
J9 NAT SCI SLEEP
JI NAT. SCI. SLEEP
PY 2025
VL 17
BP 3105
EP 3114
DI 10.2147/NSS.S570796
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA M6402
UT WOS:001630773400001
PM 41356808
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, HP
   Su, W
   Shu, Y
   Yuan, XC
   Lin, LX
   Hou, TF
   Xiang, HC
   Zhu, H
   Hu, XF
   Pan, L
   Wu, JN
   Meng, XF
   Pan, HL
   Wu, CH
   Li, M
AF Li, Hong-Ping
   Su, Wen
   Shu, Yang
   Yuan, Xiao-Cui
   Lin, Li-Xue
   Hou, Teng-Fei
   Xiang, Hong-Chun
   Zhu, He
   Hu, Xue-Fei
   Pan, Li
   Wu, Jing-Nan
   Meng, Xian-Fang
   Pan, Hui-Lin
   Wu, Cai-Hua
   Li, Man
TI Electroacupuncture decreases Netrin-1-induced myelinated afferent fiber
   sprouting and neuropathic pain through μ-opioid receptors
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE postherpetic neuralgia; analgesia; mechanical hyperalgesia; rat;
   mu-opioid receptors
ID COLORECTAL-CANCER; SENSORY NEURONS; SPINAL-CORD; MECHANICAL
   SENSITIVITIES; AXON GUIDANCE; MICE LACKING; RAT-BRAIN; EXPRESSION;
   MOUSE; DCC
AB Purpose: We determined whether electroacupuncture (EA) reduces Netrin-1-induced myelinated primary afferent nerve fiber sprouting in the spinal cord and pain hypersensitivity associated with postherpetic neuralgia (PHN) through activation of mu-opioid receptors.
   Methods: PHN was induced by systemic injection of resiniferatoxin (RTX) in rats. Thirty-six days after RTX injection, a mu-opioid receptor antagonist, beta-funaltrexamine (beta-FNA) or a kappa-opioid receptor antagonist, nor Binaltorphimine (nor-BNI), was injected intrathecally 30 mins before EA, once every other day for 4 times. Mechanical allodynia was tested with von Frey filaments. The protein expression level of Netrin-1 and its receptors (DCC and UNC5H2) were quantified by using western blotting. The myelinated primary afferent nerve fiber sprouting was mapped with the transganglionic tracer cholera toxin B-subunit (CTB).
   Results: Treatment with 2 Hz EA at "Huantiao" (GB30) and "Yanglingquan" (GB34) decreased the mechanical allodynia at 22 days and the myelinated primary afferent nerve fiber preternatural sprouting into the lamina II of the spinal dorsal horn at 42 days after RTX injection. Also, treatment with 2 Hz EA reduced the protein levels of DCC and Netrin-1 and promoted the expression of UNC5H2 in the spinal dorsal horn 42 days after RTX injection. Furthermore, the mu-opioid receptor antagonist beta-FNA, but not the kappa-opioid receptor antagonist nor-BNI, reversed the effect of EA on neuropathic pain caused by RTX. In addition, morphine inhibited the Netrin-1 protein level induced by RTX in SH-SY5Y cells.
   Conclusions: Through activation of mu-opioid receptors, treatment with EA reduces the expression level of DCC and Netrin-1 and changes a growth-permissive environment in spinal dorsal horn into an inhibitory environment by increasing UNC5H2, thus decreasing RTX-caused primary afferent nerve sprouting in the spinal dorsal horn and neuropathic pain.
C1 [Li, Hong-Ping; Yuan, Xiao-Cui; Lin, Li-Xue; Hou, Teng-Fei; Xiang, Hong-Chun; Zhu, He; Hu, Xue-Fei; Pan, Li; Wu, Jing-Nan; Meng, Xian-Fang; Wu, Cai-Hua; Li, Man] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Neurobiol, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Su, Wen; Wu, Cai-Hua] Wuhan First Hosp, Dept Acupuncture, 215 Zhongshan Ave, Wuhan 430030, Hubei, Peoples R China.
   [Shu, Yang] Jiangsu Univ, Dept Cent Lab, Affiliated Hosp, Zhenjiang 212000, Jiangsu, Peoples R China.
   [Pan, Hui-Lin] Univ Texas MD Anderson Canc Ctr, Dept Anesthesiol & Perioperat Med, Houston, TX 77030 USA.
C3 Huazhong University of Science & Technology; Jiangsu University;
   University of Texas System; UTMD Anderson Cancer Center
RP Wu, CH; Li, M (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Neurobiol, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.; Wu, CH (corresponding author), Wuhan First Hosp, Dept Acupuncture, 215 Zhongshan Ave, Wuhan 430030, Hubei, Peoples R China.
EM wch0007@126.com; liman73@mails.tjmu.edu.cn
RI Li, Man/IAO-9803-2023; li, hongping/JBR-8611-2023; Wu,
   Jingnan/MGT-7744-2025
OI Pan, Hui-Lin/0000-0001-8444-3770; Zhu, He/0000-0001-5107-7575; Xiang,
   Hongchun/0000-0002-1796-977X; wu, caihua/0000-0003-0062-5767
FU National Natural Science Foundation of China [81804187]; Natural Science
   Foundation of Jiangsu Province [BK20160548]; Major Social Development
   Project of Zhenjiang city [SH2016032]; Doctor startup Fund Program
   [JDFYRC-2015005]
FX This work was supported by a grant from the National Natural Science
   Foundation of China (No. 81804187), the Natural Science Foundation of
   Jiangsu Province (No. BK20160548), the Major Social Development Project
   of Zhenjiang city (No. SH2016032) and Doctor startup Fund Program (No.
   JDFYRC-2015005).
CR Ackerman SL, 1997, NATURE, V386, P838, DOI 10.1038/386838a0
   Bakkum BW, 2007, J MANIP PHYSIOL THER, V30, P336, DOI 10.1016/j.jmpt.2007.04.007
   CHAPLAN SR, 1994, J NEUROSCI METH, V53, P55, DOI 10.1016/0165-0270(94)90144-9
   Chen L, 2009, J PAIN, V10, P732, DOI 10.1016/j.jpain.2008.12.012
   Chen SR, 2006, J NEUROPHYSIOL, V95, P3086, DOI 10.1152/jn.01343.2005
   Engelkamp D, 2002, MECH DEVELOP, V118, P191, DOI 10.1016/S0925-4773(02)00248-4
   Fazeli A, 1997, NATURE, V386, P796, DOI 10.1038/386796a0
   FEARON ER, 1990, SCIENCE, V247, P49, DOI 10.1126/science.2294591
   Grachev YV, 1998, ZH NEVROPATOL PSIKH, V98, P4
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   Keeling SL, 1997, ONCOGENE, V15, P691, DOI 10.1038/sj.onc.1201225
   KeinoMasu K, 1996, CELL, V87, P175, DOI 10.1016/S0092-8674(00)81336-7
   Khan GM, 2002, NEUROSCIENCE, V114, P291, DOI 10.1016/S0306-4522(02)00372-X
   Kieffer BL, 2009, NEUROPHARMACOLOGY, V56, P205, DOI 10.1016/j.neuropharm.2008.07.033
   Kim HY, 2009, PAIN, V145, P332, DOI 10.1016/j.pain.2009.06.035
   Kim JH, 2004, BRAIN RES, V998, P230, DOI 10.1016/j.brainres.2003.11.045
   Komatsuzaki K, 2002, BIOCHEM BIOPH RES CO, V297, P898, DOI 10.1016/S0006-291X(02)02277-5
   Leonardo ED, 1997, NATURE, V386, P833, DOI 10.1038/386833a0
   Liu H, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/848603
   Liu N, 2011, NEUROSCIENCE, V194, P349, DOI 10.1016/j.neuroscience.2011.07.037
   Manitt C, 2001, J NEUROSCI, V21, P3911, DOI 10.1523/JNEUROSCI.21-11-03911.2001
   Manitt C, 2004, J NEUROSCI RES, V77, P690, DOI 10.1002/jnr.20199
   Manitt C, 2006, J NEUROSCI RES, V84, P1808, DOI 10.1002/jnr.21070
   Mao-Ying QL, 2006, EUR J PAIN, V10, P689, DOI 10.1016/j.ejpain.2005.11.001
   Matthes HWD, 1996, NATURE, V383, P819, DOI 10.1038/383819a0
   Mehlen P, 2004, J CLIN ONCOL, V22, P3420, DOI 10.1200/JCO.2004.02.019
   Meyerhardt JA, 1997, ONCOGENE, V14, P1129, DOI 10.1038/sj.onc.1200935
   Mintz CD, 2013, ANESTHESIOLOGY, V118, P825, DOI 10.1097/ALN.0b013e318287b850
   Ossipov MH, 2010, J CLIN INVEST, V120, P3779, DOI 10.1172/JCI43766
   Pan HL, 2003, J NEUROSCI, V23, P2911
   Philip A, 2011, J PALLIAT MED, V14, P765, DOI 10.1089/jpm.2011.9685
   Richards LJ, 1997, J NEUROSCI, V17, P2445
   Serafini T, 1996, CELL, V87, P1001, DOI 10.1016/S0092-8674(00)81795-X
   Sora I, 1997, P NATL ACAD SCI USA, V94, P1544, DOI 10.1073/pnas.94.4.1544
   Stein C, 2011, PHARMACOL REV, V63, P860, DOI 10.1124/pr.110.003145
   Thiébault K, 2003, P NATL ACAD SCI USA, V100, P4173, DOI 10.1073/pnas.0738063100
   Ugur M, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01240
   VANCANEGHEM P, 1975, CR SOC BIOL, V169, P242
   Wang Chen-Yao, 2012, Zhen Ci Yan Jiu, V37, P64
   Wang LN, 2006, BRAIN RES, V1120, P46, DOI 10.1016/j.brainres.2006.08.077
   Wang XD, 2013, NEURAL REGEN RES, V8, P64, DOI 10.3969/j.issn.1673-5374.2013.01.008
   WARD SJ, 1982, J PHARMACOL EXP THER, V220, P494
   WARD SJ, 1985, EUR J PHARMACOL, V107, P323, DOI 10.1016/0014-2999(85)90257-2
   Wehrle R, 2005, EUR J NEUROSCI, V22, P2134, DOI 10.1111/j.1460-9568.2005.04419.x
   Williams ME, 2003, J NEUROSCI, V23, P11279
   Wu CH, 2016, MOL NEUROBIOL, V53, P5640, DOI 10.1007/s12035-015-9482-x
   Wu CH, 2013, MOL PAIN, V9, DOI 10.1186/1744-8069-9-18
   Yuan XY, 2017, APPL SPECTROSC, V71, P2325, DOI 10.1177/0003702817721527
   Zhang RX, 2005, BRAIN RES, V1048, P235, DOI 10.1016/j.brainres.2005.05.008
   Zhang RX, 2004, BRAIN RES, V1020, P12, DOI 10.1016/j.brainres.2004.05.067
   ZIMMERMANN M, 1983, PAIN, V16, P109, DOI 10.1016/0304-3959(83)90201-4
   2011, DEVELOPMENT, V138, P2153, DOI DOI 10.1242/DEV.044529
NR 52
TC 27
Z9 37
U1 2
U2 14
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2019
VL 12
BP 1259
EP 1268
DI 10.2147/JPR.S191900
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HU8ME
UT WOS:000465541900001
PM 31118749
OA Green Published, gold
DA 2026-01-16
ER

PT J
AU Hack, CC
   Häberle, L
   Brucker, SY
   Janni, W
   Volz, B
   Loehberg, CR
   Hartkopf, AD
   Walter, CB
   Baake, G
   Fridman, A
   Malter, W
   Wuerstlein, R
   Harbeck, N
   Hoffmann, O
   Kuemmel, S
   Martin, B
   Thomssen, C
   Graf, H
   Wolf, C
   Lux, MP
   Bayer, CM
   Rauh, C
   Almstedt, K
   Gass, P
   Heindl, F
   Brodkorb, T
   Willer, L
   Lindner, C
   Kolberg, HC
   Krabisch, P
   Weigel, M
   Steinfeld-Birg, D
   Kohls, A
   Brucker, C
   Schulz, 
   Fischer, G
   Pelzer, 
   Rack, B
   Beckmann, MW
   Fehm, T
   Rody, A
   Maass, N
   Hein, A
   Fasching, PA
   Nabieva, N
AF Hack, C. C.
   Haeberle, L.
   Brucker, S. Y.
   Janni, W.
   Volz, B.
   Loehberg, C. R.
   Hartkopf, A. D.
   Walter, C-B
   Baake, G.
   Fridman, A.
   Malter, W.
   Wuerstlein, R.
   Harbeck, N.
   Hoffmann, O.
   Kuemmel, S.
   Martin, B.
   Thomssen, C.
   Graf, H.
   Wolf, C.
   Lux, M. P.
   Bayer, C. M.
   Rauh, C.
   Almstedt, K.
   Gass, P.
   Heindl, F.
   Brodkorb, T.
   Willer, L.
   Lindner, C.
   Kolberg, H-C
   Krabisch, P.
   Weigel, M.
   Steinfeld-Birg, D.
   Kohls, A.
   Brucker, C.
   Schulz, V
   Fischer, G.
   Pelzer, V
   Rack, B.
   Beckmann, M. W.
   Fehm, T.
   Rody, A.
   Maass, N.
   Hein, A.
   Fasching, P. A.
   Nabieva, N.
TI Complementary and alternative medicine and musculoskeletal pain in the
   first year of adjuvant aromatase inhibitor treatment in early breast
   cancer patients
SO BREAST
LA English
DT Article
DE Breast cancer; Endocrine therapy/treatment; Aromatase inhibitors;
   Letrozole; Integrative medicine; Complementary and alternative medicine;
   Arthralgia; Myalgia
ID POSTMENOPAUSAL WOMEN; INDUCED ARTHRALGIA; ENDOCRINE THERAPY; CONTROLLED
   TRIAL; FREE SURVIVAL; SYMPTOMS; TAMOXIFEN; ACUPUNCTURE; PERSONALITY;
   ANASTROZOLE
AB Background: Patients with breast cancer (BC) show strong interest in complementary and alternative medicine (CAM), particularly for adverse effects of adjuvant endocrine treatment - e.g., with letrozole. Letrozole often induces myalgia/limb pain and arthralgia, with potential noncompliance and treatment termination. This analysis investigated whether CAM before aromatase inhibitor (AI) therapy is associated with pain development and the intensity of AI-induced musculoskeletal syndrome (AIMSS) during the first year of treatment.
   Patients and methods: The multicenter phase IV PreFace study evaluated letrozole therapy in post-menopausal, hormone receptor-positive patients with early BC. Patients were asked about CAM use before, 6 months after, and 12 months after treatment started. They recorded pain every month for 1 year in a diary including questions about pain and numeric pain rating scales. Data were analyzed for patients who provided pain information for all time points.
   Results: Of 1396 patients included, 901 (64.5%) had used CAM before AI treatment. Throughout the observation period, patients with CAM before AI treatment had higher pain values, for both myalgia/limb pain and arthralgia, than non-users. Pain increased significantly in both groups over time, with the largest increase during the first 6 months. No significant difference of pain increase was noted regarding CAM use.
   Conclusions: CAM use does not prevent or improve the development of AIMSS. Pain intensity was generally greater in the CAM group. Therefore, because of the risk of non-compliance and treatment discontinuation due to the development of higher pain levels, special attention must be paid to patient education and aftercare in these patients. (C) 2020 The Author(s). Published by Elsevier Ltd.
C1 [Hack, C. C.; Haeberle, L.; Volz, B.; Loehberg, C. R.; Lux, M. P.; Bayer, C. M.; Rauh, C.; Almstedt, K.; Gass, P.; Heindl, F.; Brodkorb, T.; Willer, L.; Beckmann, M. W.; Hein, A.; Fasching, P. A.; Nabieva, N.] Friedrich Alexander Univ Erlangen Nuremberg, Erlangen Univ Hosp, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol, Erlangen, Germany.
   [Haeberle, L.] Erlangen Univ Hosp, Dept Gynecol, Biostat Unit, Erlangen, Germany.
   [Brucker, S. Y.; Hartkopf, A. D.; Walter, C-B; Fehm, T.] Univ Tubingen, Dept Gynecol, Tubingen, Germany.
   [Janni, W.; Rack, B.] Ulm Univ Hosp, Dept Gynecol, Ulm, Germany.
   [Loehberg, C. R.] St Theresien Hosp, Nurnberg, Germany.
   [Baake, G.] Oncol Med Practice Pinneberg, Pinneberg, Germany.
   [Fridman, A.; Malter, W.; Wuerstlein, R.; Harbeck, N.] Univ Cologne Hosp, Breast Ctr, Dept Obstet & Gynecol, Cologne, Germany.
   [Fridman, A.] Evangelisches Krankenhaus Kalk, Cologne, Germany.
   [Wuerstlein, R.; Harbeck, N.] Univ Munich LMU, Breast Ctr, Dept Gynecol & Obstet, Munich, Germany.
   [Fridman, A.] Univ Munich LMU, CCC Munich, Munich, Germany.
   [Hoffmann, O.] Essen Univ Hosp, Dept Gynecol, Essen, Germany.
   [Kuemmel, S.] Evang Huyssens Stiftung Knappschaft GmbH, Breast Unit, Essen Mitte Clin, Essen, Germany.
   [Martin, B.] Tuttlingen Clin, Tuttlingen, Germany.
   [Thomssen, C.] Martin Luther Univ Halle Wittenberg, Dept Gynecol, Halle, Saale, Germany.
   [Graf, H.] Helios Clin Meiningen, Meiningen, Germany.
   [Wolf, C.] Ulm Med Ctr, Ulm, Germany.
   [Almstedt, K.] Mainz Univ Hosp, Dept Gynecol, Mainz, Germany.
   [Lindner, C.] Agaplesion Diakonie Clin Hamburg, Hamburg, Germany.
   [Kolberg, H-C] Marienhosp Bottrop, Dept Gynecol & Obstet, Bottrop, Germany.
   [Krabisch, P.] Klinikum Chemnitz gGmbH, Dept Gynecol, Chemnitz, Germany.
   [Weigel, M.] Leopoldina Hosp Schweinfurt, Dept Gynecol, Schweinfurt, Germany.
   [Steinfeld-Birg, D.] Gynecol Onocol Practice Steinfeld Birg, Augsburg, Germany.
   [Kohls, A.] Protestant Cty Hosp Ludwigsfelde Teltow, Ludwigsfelde Teltow, Germany.
   [Brucker, C.] Paracelsus Med Univ, Nuremberg Gen Hosp, Dept Gynecol & Obstet, Nurnberg, Germany.
   [Schulz, V] Gynecol Practice Abts Partner, Kiel, Germany.
   [Fischer, G.] Mittweida Hosp gGmbH, Mittweida, Germany.
   [Pelzer, V] GFO Clin Bonn, Dept Gynecol, Bonn, Germany.
   [Fehm, T.] Heinrich Heine Univ Dusseldorf, Dept Gynecol, Dusseldorf, Germany.
   [Rody, A.] Schleswig Holstein Univ Hosp, Dept Gynecol, Campus Lubeck, Schleswig Holstein, Germany.
   [Maass, N.] Schleswig Holstein Univ Hosp, Dept Gynecol, Campus Kiel, Schleswig Holstein, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg;
   Eberhard Karls University of Tubingen; Ulm University; University of
   Cologne; University of Munich; University of Munich; University of
   Duisburg Essen; Kliniken Essen-Mitte; Martin Luther University Halle
   Wittenberg; University Hospital Mainz; St. Marien Hospital; Chemnitz
   Clinic; Heinrich Heine University Dusseldorf
RP Fasching, PA (corresponding author), Erlangen Univ Hosp, Dept Gynecol, Univ Str 21-23, D-91054 Erlangen, Germany.; Fasching, PA (corresponding author), Univ Breast Ctr Franconia, Univ Str 21-23, D-91054 Erlangen, Germany.; Fasching, PA (corresponding author), European Metropolitan Area Nuremberg CCC ER EMN, Comprehens Canc Ctr Erlangen, Univ Str 21-23, D-91054 Erlangen, Germany.; Fasching, PA (corresponding author), Friedrich Alexander Univ Erlangen Nuremberg, Univ Str 21-23, D-91054 Erlangen, Germany.
EM peter.fasching@uk-erlangen.de
RI Thomssen, Christoph/ABC-3102-2021; Kuemmel, Sherko/AFV-3420-2022;
   Fasching, Peter/ABH-9912-2020; Harbeck, Nadia/JOZ-6178-2023; Heindl,
   Felix/AAU-7766-2020
OI Rauh, Claudia/0009-0006-0777-2523; Fehm, Tanja/0000-0002-4926-0108; 
CR Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Baum M, 2002, LANCET, V359, P2131
   Beckwée D, 2017, SUPPORT CARE CANCER, V25, P1673, DOI 10.1007/s00520-017-3613-z
   Briot K, 2010, BREAST CANCER RES TR, V120, P127, DOI 10.1007/s10549-009-0692-7
   Burstein HJ, 1999, NEW ENGL J MED, V340, P1733, DOI 10.1056/NEJM199906033402206
   Chen L, 2017, BREAST, V33, P132, DOI 10.1016/j.breast.2017.03.015
   Chirgwin JH, 2016, J CLIN ONCOL, V34, P2452, DOI 10.1200/JCO.2015.63.8619
   Colleoni M, 2011, J CLIN ONCOL, V29, P1117, DOI 10.1200/JCO.2010.31.6455
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Davidson R, 2005, PSYCHO-ONCOLOGY, V14, P187, DOI 10.1002/pon.834
   DiGianni LM, 2002, J CLIN ONCOL, V20, p34S, DOI 10.1200/JCO.2002.07.176
   Dowsett M, 2015, LANCET, V386, P1341, DOI 10.1016/S0140-6736(15)61074-1
   Fremd C, 2017, ARCH GYNECOL OBSTET, V295, P1239, DOI 10.1007/s00404-017-4348-2
   Galantino ML, 2012, EXPLORE-NY, V8, P40, DOI 10.1016/j.explore.2011.10.002
   Hack CC, 2017, INTEGR CANCER THER, V16, P165, DOI 10.1177/1534735416668575
   Hadji P, 2014, ANN ONCOL, V25, P372, DOI 10.1093/annonc/mdt513
   Hadji P, 2013, ANN ONCOL, V24, P1505, DOI 10.1093/annonc/mds653
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Hershman DL, 2015, J CLIN ONCOL, V33, P1910, DOI 10.1200/JCO.2014.59.5595
   Honda K, 2005, PREV MED, V40, P46, DOI 10.1016/j.ypmed.2004.05.001
   Horneber M, 2012, INTEGR CANCER THER, V11, P187, DOI 10.1177/1534735411423920
   Irwin ML, 2015, J CLIN ONCOL, V33, P1104, DOI 10.1200/JCO.2014.57.1547
   Jacobsen PB, 2015, PSYCHO-ONCOLOGY, V24, P1578, DOI 10.1002/pon.3756
   Johnson SB, 2018, JAMA ONCOL, V4, P1375, DOI 10.1001/jamaoncol.2018.2487
   Lash BW, 2011, J CLIN ONCOL, V29, DOI 10.1200/jco.2011.29.15_suppl.e19725
   Lohrisch CA, 2011, J CLIN ONCOL, V29, DOI 10.1200/jco.2011.29.15_suppl.636
   Lombard JM, 2016, SUPPORT CARE CANCER, V24, P2139, DOI 10.1007/s00520-015-3001-5
   Möbus V, 2017, GEBURTSH FRAUENHEILK, V77, P1079, DOI 10.1055/s-0043-119542
   Molassiotis A, 2005, ANN ONCOL, V16, P655, DOI 10.1093/annonc/mdi110
   Moschèn R, 2001, SUPPORT CARE CANCER, V9, P267, DOI 10.1007/s005200000208
   Nabieva N, 2018, ANN ONCOL, V29, P186, DOI 10.1093/annonc/mdx630
   O'Connor Casey, 2016, Hand (N Y), V11, P295, DOI 10.1177/1558944715620798
   Peppone LJ, 2015, BREAST CANCER RES TR, V150, P597, DOI 10.1007/s10549-015-3351-1
   Prieto-Alhambra D, 2011, BREAST CANCER RES TR, V125, P869, DOI 10.1007/s10549-010-1075-9
   Roberts K, 2017, CRIT REV ONCOL HEMAT, V111, P66, DOI 10.1016/j.critrevonc.2017.01.010
   Scharl A, 2016, GEBURTSH FRAUENHEILK, V76, P516, DOI 10.1055/s-0042-106389
   Sirois FM, 2008, J ALTERN COMPLEM MED, V14, P1151, DOI 10.1089/acm.2007.0801
   Stearns V, 2015, J CLIN ONCOL, V33, P265, DOI 10.1200/JCO.2014.57.6926
   Templeton AJ, 2013, BMC CANCER, V13, DOI 10.1186/1471-2407-13-153
   Thorne C, 2007, Curr Oncol, V14 Suppl 1, pS11, DOI 10.3747/co.2007.152
   Thürlimann B, 2005, NEW ENGL J MED, V353, P2747
   Toivonen KI, 2018, INTEGR CANCER THER, V17, P785, DOI 10.1177/1534735417753539
   Untch M, 2017, GEBURTSH FRAUENHEILK, V77, P633, DOI 10.1055/s-0043-111601
NR 43
TC 7
Z9 7
U1 1
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0960-9776
EI 1532-3080
J9 BREAST
JI Breast
PD APR
PY 2020
VL 50
BP 11
EP 18
DI 10.1016/j.breast.2019.12.017
PG 8
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA KU6HI
UT WOS:000519815500002
PM 31958661
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lee, SM
   Choi, HC
   Hyun, MK
AF Lee, Seong Min
   Choi, Ho Cheol
   Hyun, Min Kyung
TI An Overview of Systematic Reviews: Complementary Therapies for Cancer
   Patients
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE Complementary therapies; cancer; Assessing the Methodological Quality of
   Systematic Reviews 2; AMSTAR2
ID QUALITY-OF-LIFE; TRADITIONAL CHINESE MEDICINE; COMPOUND KUSHEN
   INJECTION; BREAST-CANCER; ALTERNATIVE MEDICINE; HERBAL MEDICINE;
   TAI-CHI; COLORECTAL-CANCER; ADJUNCTIVE THERAPY; MASSAGE THERAPY
AB Introduction: This article critically examines the systematic reviews (SR) and meta-analysis (MA) of complementary therapies for cancer patients to appraise the evidence level, and offers suggestions for future research and practice. Methods: The Cochrane Library and MEDLINE were searched from their inception to January 2018, to identify SR and MA of complementary therapies available for cancer patients. Final selected SR and MA were methodologically evaluated for their quality by applying the Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR2) instrument. Data extraction and risk of quality assessments were performed by 2 independent reviewers. Results: A total of 104 studies were included in the analysis. The majority of the individual clinical trials included in the SR and MA were performed in China (48%) and the United States (26.9%). Breast cancer was the most studied cancer type (25%), and acupuncture was the most studied intervention (21%). Side effects of cancer such as pain, depression, and fatigue were effectively managed with complementary therapies. The methodologically problematic items included not listing the excluded studies and lack of protocol or protocol registration. Conclusions: With increasing interest in research, complementary therapies appear to be beneficial in reducing side effects and raising the quality of life of cancer patients. Complementary therapies have generally been studied for all cancers, with acupuncture being the most researched, regardless of the cancer type. Since AMSTAR2 is a stricter assessment tool than before, future studies need to consider the risk of methodological bias with caution and discuss appropriate overall quality assessment tools.
C1 [Lee, Seong Min; Choi, Ho Cheol] Dongguk Univ, Coll Korean Med, Gyeongju, South Korea.
   [Hyun, Min Kyung] Dongguk Univ, Dept Prevent Med, Coll Korean Med, Gyeongju, South Korea.
C3 Dongguk University; Dongguk University
RP Hyun, MK (corresponding author), Dongguk Univ, Coll Korean Med, Dept Prevent Med, 123 Dongdae Ro, Gyeongju Si 38066, Gyeongsanbuk Do, South Korea.
EM mk3three@dongguk.ac.kr
RI ; Hyun, Min Kyung/C-1534-2010
OI LEE, SEONG MIN/0000-0003-3056-2509; Hyun, Min Kyung/0000-0003-0212-8633
FU National Research Foundation of Korea (NRF) - Korea government (Ministry
   of Science and ICT) [2016R1C1B3006806]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the National Research Foundation of Korea (NRF) grant
   funded by the Korea government (Ministry of Science and ICT; No.
   2016R1C1B3006806).
CR Archer S, 2015, PSYCHO-ONCOLOGY, V24, P1, DOI 10.1002/pon.3607
   Arthur K, 2012, INTEGR CANCER THER, V11, P232, DOI 10.1177/1534735411433832
   Bao YJ, 2014, SUPPORT CARE CANCER, V22, P825, DOI 10.1007/s00520-013-2063-5
   Bardia A, 2006, J CLIN ONCOL, V24, P5457, DOI 10.1200/JCO.2006.08.3725
   Barnes Patricia M, 2008, Natl Health Stat Report, P1
   Bergenthal N, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009075.pub2
   Bradt J, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006911.pub3
   Buckner CA, 2018, CURR ONCOL, V25, pE275, DOI 10.3747/co.25.3884
   Buffart LM, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-559
   Campbell CL, 2012, PATIENT EDUC COUNS, V89, P15, DOI 10.1016/j.pec.2012.06.019
   Cao HJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160253
   Carayol M, 2015, PSYCHO-ONCOLOGY, V24, P737, DOI 10.1002/pon.3727
   Chan CLW, 2012, SUPPORT CARE CANCER, V20, P1121, DOI 10.1007/s00520-011-1378-3
   Chao LF, 2009, BREAST CANCER RES TR, V118, P255, DOI 10.1007/s10549-009-0533-8
   Chen MH, 2014, PHYTOTHER RES, V28, P976, DOI 10.1002/ptr.5092
   Chen X, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004520.pub7
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Choi TY, 2015, SUPPORT CARE CANCER, V23, P1819, DOI 10.1007/s00520-014-2530-7
   Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
   Chung VCH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002793
   Cramer H, 2012, CURR ONCOL, V19, pE343, DOI 10.3747/co.19.1016
   Cramer H, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010802.pub2
   Cramer H, 2015, INTEGR CANCER THER, V14, P5, DOI 10.1177/1534735414550035
   Cramer H, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-412
   Ernst E, 2003, INT J CANCER, V107, P262, DOI 10.1002/ijc.11386
   Ernst E, 2009, SUPPORT CARE CANCER, V17, P333, DOI 10.1007/s00520-008-0569-z
   Ernst E, 2006, BREAST J, V12, P526, DOI 10.1111/j.1524-4741.2006.00340.x
   Ezzo J, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003475.pub2
   Felbel S, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010146.pub2
   Fitzmaurice C, 2017, JAMA ONCOL, V3, P524, DOI [10.1001/jamaoncol.2016.5688, 10.1001/jamaoncol.2018.2706]
   Garcia MK, 2013, J CLIN ONCOL, V31, P952, DOI 10.1200/JCO.2012.43.5818
   Gorin SS, 2012, J CLIN ONCOL, V30, P539, DOI 10.1200/JCO.2011.37.0437
   Harder H, 2012, SUPPORT CARE CANCER, V20, P3055, DOI 10.1007/s00520-012-1611-8
   He WB, 2019, COMPLEMENT THER MED, V42, P407, DOI 10.1016/j.ctim.2018.12.020
   Hulett JM, 2016, INTEGR CANCER THER, V15, P405, DOI 10.1177/1534735416636222
   Kassab S, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004845.pub2
   Kim JI, 2010, INTEGR CANCER THER, V9, P326, DOI 10.1177/1534735410387423
   Kim KH, 2016, ACUPUNCT MED, V34, P248, DOI 10.1136/acupmed-2015-010941
   Kim W, 2015, COMPLEMENT THER MED, V23, P626, DOI 10.1016/j.ctim.2015.03.011
   Kim W, 2015, INTEGR CANCER THER, V14, P212, DOI 10.1177/1534735415572881
   Klein PJ, 2016, SUPPORT CARE CANCER, V24, P3209, DOI 10.1007/s00520-016-3201-7
   Koithan Mary, 2009, J Nurse Pract, V5, P18
   Lau CHY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002901
   Lee JW, 2015, COMPLEMENT THER MED, V23, P265, DOI 10.1016/j.ctim.2015.02.003
   Lee MS, 2007, ACTA ONCOL, V46, P717, DOI 10.1080/0284160701261584
   Lee MS, 2007, SUPPORT CARE CANCER, V15, P597, DOI 10.1007/s00520-007-0221-3
   Lee MS, 2010, BMC CANCER, V10, DOI 10.1186/1471-2407-10-130
   Lee MS, 2010, BREAST CANCER RES TR, V120, P309, DOI 10.1007/s10549-010-0741-2
   Lee PLT, 2016, COMPLEMENT THER MED, V27, P87, DOI 10.1016/j.ctim.2016.06.003
   Lee S, 2014, SUPPORT CARE CANCER, V22, P1429, DOI 10.1007/s00520-014-2161-z
   Lee SH, 2015, INTEGR CANCER THER, V14, P297, DOI 10.1177/1534735415572885
   Lian WL, 2014, CHIN J INTEGR MED, V20, P136, DOI 10.1007/s11655-013-1439-1
   Mansky PJ, 2006, CANCER J, V12, P425, DOI 10.1097/00130404-200609000-00011
   McCulloch M, 2006, J CLIN ONCOL, V24, P419, DOI 10.1200/JCO.2005.03.6392
   McCulloch M, 2016, INTEGR CANCER THER, V15, P285, DOI 10.1177/1534735416638738
   Milazzo S, 2006, EUR J CANCER, V42, P282, DOI 10.1016/j.ejca.2005.09.025
   Nie Yan-li, 2012, J Evid Based Med, V5, P216, DOI 10.1111/jebm.12001
   Oh B, 2012, INTEGR CANCER THER, V11, P101, DOI 10.1177/1534735411413268
   Oh PJ, 2014, ONCOL NURS FORUM, V41, pE290, DOI 10.1188/14.ONF.E290-E301
   Paley CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007753.pub3
   Pan YQ, 2014, INT J CLIN ONCOL, V19, P829, DOI 10.1007/s10147-013-0635-5
   Pan YQ, 2017, ASIA-PAC J CLIN ONCO, V13, pE79, DOI 10.1111/ajco.12329
   Pearce A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184360
   Posadzki P, 2013, CLIN MED, V13, P126, DOI 10.7861/clinmedicine.13-2-126
   Puetz TW, 2013, JAMA INTERN MED, V173, P960, DOI 10.1001/jamainternmed.2013.836
   Roffe L, 2005, PSYCHO-ONCOLOGY, V14, P607, DOI 10.1002/pon.889
   Rossi E, 2015, SUPPORT CARE CANCER, V23, P1795, DOI 10.1007/s00520-014-2517-4
   Salhofer I, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011157.pub2
   Shea BJ, 2017, BMJ-BRIT MED J, V358, DOI 10.1136/bmj.j4008
   Shin ES, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009873.pub3
   Shneerson C, 2013, COMPLEMENT THER MED, V21, P417, DOI 10.1016/j.ctim.2013.05.003
   Siegel RL, 2018, CA-CANCER J CLIN, V68, P7, DOI [10.3322/caac.21442, 10.3322/caac.21551]
   Sun QZ, 2012, AFR J TRADIT COMPLEM, V9, P178, DOI 10.4314/ajtcam.v9i2.1
   Tao WW, 2016, J PAIN SYMPTOM MANAG, V51, P728, DOI 10.1016/j.jpainsymman.2015.11.027
   Tao WW, 2015, ONCOTARGET, V6, P39725, DOI 10.18632/oncotarget.5388
   van Die MD, 2016, BJU INT, V117, P17, DOI 10.1111/bju.13361
   Walsh D, 2000, SUPPORT CARE CANCER, V8, P175, DOI 10.1007/s005200050281
   Wang SS, 2016, J CANCER RES THER, V12, P1298, DOI 10.4103/0973-1482.199538
   Wilkinson S, 2008, J ADV NURS, V63, P430, DOI 10.1111/j.1365-2648.2008.04712.x
   World Health Organization, Diagnosis and treatment
   Wu P, 2009, J EXP CLIN CANC RES, V28, DOI 10.1186/1756-9966-28-112
   Xu M, 2009, J ALTERN COMPLEM MED, V15, P1347, DOI 10.1089/acm.2009.0202
   Yan JH, 2014, ASIAN PAC J CANCER P, V15, P3715, DOI 10.7314/APJCP.2014.15.8.3715
   Yan XY, 2016, SUPPORT CARE CANCER, V24, P11, DOI 10.1007/s00520-015-2737-2
   Yang S, 2012, CHIN J INTEGR MED, V18, P862, DOI 10.1007/s11655-012-1111-1
   Yun Hyeongjun, 2017, Journal of the National Cancer Institute Monographs, P29, DOI [10.1093/jncimonographs/lgx004, 10.1093/jncimonographs/lgx004]
   Zeng YC, 2014, INTEGR CANCER THER, V13, P193, DOI 10.1177/1534735413510024
   Zeng YC, 2014, COMPLEMENT THER MED, V22, P173, DOI 10.1016/j.ctim.2013.11.010
   Zhang FR, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/8791538
   Zhang J, 2012, J ALTERN COMPLEM MED, V18, P994, DOI 10.1089/acm.2011.0514
   Zhang JM, 2012, SUPPORT CARE CANCER, V20, P3043, DOI 10.1007/s00520-012-1606-5
   Zhang M, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004921.pub2
   Zhong LLD, 2012, COMPLEMENT THER MED, V20, P240, DOI 10.1016/j.ctim.2012.02.004
NR 93
TC 35
Z9 41
U1 1
U2 21
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD DEC
PY 2019
VL 18
AR 1534735419890029
DI 10.1177/1534735419890029
PG 11
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Integrative & Complementary Medicine
GA JY9HK
UT WOS:000504717000001
PM 31876212
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Jin, RR
   Wu, BL
   Zhang, XD
   Hu, WY
   Wang, ZJ
   Xie, SR
AF Jin, Ru-Ru
   Wu, Bei-Lei
   Zhang, Xiao-Dan
   Hu, Wei-Yan
   Wang, Zhe-Jin
   Xie, Shang-Ren
TI Accelerated Rehabilitation Surgery Nursing Combined with Traditional
   Chinese Medicine Acupoint Application Therapy in Postoperative
   Rehabilitation of Elderly Patients with Liver Cancer
SO ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH
LA English
DT Article; Early Access
DE liver cancer; postoperative rehabilitation; pain management; opioid
   reduction; inflammatory markers; quality of life
ID INTEGRATIVE MEDICINE; PAIN MANAGEMENT; ACUPUNCTURE
AB The purpose of the study is to evaluate the effectiveness of acupoint therapy in the comprehensive postoperative management of patients with liver cancer, aiming to reduce pain, decrease the need for opioid analgesics, and improve quality of life. The study was conducted in China at Wenzhou Central Hospital. A total of 156 patients who had undergone liver resection surgery for liver cancer were included. The patients were randomized into two groups: the experimental group (n = 79), which received standard postoperative rehabilitation combined with acupoint therapy, and the control group (n = 77), which received only standard postoperative rehabilitation. Patient assessment was conducted at three time points: before treatment initiation (T0), on the 4th day of therapy (T1), and 2 weeks after completion of the course (T2). Twelve nurses participated in the study and recorded sleep quality, appetite, need for assistance, behavioral distress signs, and frequency of PRN interventions. The results of this study confirm the effectiveness of acupoint therapy as an adjunctive method in the rehabilitation process following liver cancer surgery. The practical value lies in the potential for reducing the pharmacological burden, decreasing the frequency of opioid-related side effects, and accelerating patient recovery.
C1 [Jin, Ru-Ru; Wu, Bei-Lei; Wang, Zhe-Jin] Wenzhou Cent Hosp, Dept Hepatobiliary Surg, Wenzhou, Peoples R China.
   [Zhang, Xiao-Dan; Hu, Wei-Yan] Wenzhou Cent Hosp, Dept Emergency Surg, Wenzhou, Peoples R China.
   [Zhang, Xiao-Dan; Hu, Wei-Yan; Xie, Shang-Ren] Wenzhou Cent Hosp, Dept Tradit Chinese Med, Wenzhou, Peoples R China.
RP Wang, ZJ (corresponding author), Wenzhou Cent Hosp, Dept Hepatobiliary Surg, Wenzhou, Peoples R China.
EM zhejinwang78@outlook.com
FU Wenzhou City Scientific Research Project [Y20220704]
FX Wenzhou City Scientific Research Project (Project Number: Y20220704).
CR Cao C., 2020, Investigacion Clinica, V61, P1183
   Chang XL, 2023, BMC COMPLEMENT MED, V23, DOI 10.1186/s12906-023-04075-9
   Chen J, 2024, J INTEGR COMPLEMENT, V30, P493, DOI 10.1089/jicm.2023.0272
   Curseen KA, 2020, MED CLIN N AM, V104, P415, DOI 10.1016/j.mcna.2020.01.005
   Dudek P, 2021, J CLIN MED, V10, DOI 10.3390/jcm10163662
   Echeverria-Villalobos M, 2020, CLIN J PAIN, V36, P219, DOI 10.1097/AJP.0000000000000792
   Faria M, 2024, J INTEGR MED-JIM, V22, P235, DOI 10.1016/j.joim.2024.03.002
   Giovannini S, 2021, DIAGNOSTICS, V11, DOI 10.3390/diagnostics11040613
   Iliescu MG, 2024, J CLIN MED, V13, DOI 10.3390/jcm13051190
   Invernizzi M, 2022, ANTI-CANCER AGENT ME, V22, P801, DOI 10.2174/1871520621666210609095602
   Isozaki AB, 2024, SEMIN ONCOL NURS, V40, DOI 10.1016/j.soncn.2024.151672
   Li J, 2011, CHIN J INTEGR MED, V17, P243, DOI 10.1007/s11655-011-0712-4
   Liou KT, 2021, ACUPUNCT MED, V39, P637, DOI 10.1177/0964528421999395
   Liu XY, 2022, TRIALS, V23, DOI 10.1186/s13063-022-06003-7
   Mai QL, 2022, EUR J INTEGR MED, V51, DOI 10.1016/j.eujim.2022.102120
   Majd I, 2025, ACUPUNCT MED, V43, P52, DOI 10.1177/09645284251314188
   Majid M, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.50633
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mayer RS, 2022, ANN REHABIL MED-ARM, V46, P60, DOI 10.5535/arm.22036
   Miyazaki T, 2024, J THORAC DIS, V16, P3422, DOI 10.21037/jtd-24-158
   Niyonkuru E, 2025, PAIN THER, V14, P121, DOI 10.1007/s40122-024-00688-1
   Pugh TM, 2021, FRONT PAIN RES, V2, DOI 10.3389/fpain.2021.688511
   Sun LX, 2024, INT J COLORECTAL DIS, V39, DOI 10.1007/s00384-024-04768-8
   Taleban S, 2016, DIGEST LIVER DIS, V48, P1105, DOI 10.1016/j.dld.2016.05.006
   Tang ZY, 2012, CHIN J INTEGR MED, V18, P323, DOI 10.1007/s11655-012-1103-1
   Tong QY, 2025, J PERIANESTH NURS, V40, P535, DOI [10.1016/j.jopan.2024.06.110, 10.1016/j.jopan.2024.06.110]
   Wang J, 2023, PAIN THER, V12, P707, DOI 10.1007/s40122-023-00493-2
   Wang LJ, 2024, BMC NURS, V23, DOI 10.1186/s12912-024-02144-z
   Wang XB, 2022, CLIN NURS RES, V31, P1100, DOI 10.1177/10547738221090556
   Wei W, 2024, FRONT ONCOL, V14, DOI 10.3389/fonc.2024.1322196
   Yan YQ, 2023, CANCER MED-US, V12, P12504, DOI 10.1002/cam4.5962
   Zhang YJ, 2023, FRONT ONCOL, V13, DOI 10.3389/fonc.2023.1169458
NR 32
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0360-1293
EI 2167-9010
J9 ACUPUNCTURE ELECTRO
JI Acupunct. Electro-Ther. Res.
PD 2025 DEC 3
PY 2025
DI 10.1177/03601293251397402
EA DEC 2025
PG 15
WC Integrative & Complementary Medicine; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Neurosciences & Neurology
GA L4632
UT WOS:001629588700001
DA 2026-01-16
ER

PT J
AU Holz, SC
AF Holz, Sara Christensen
TI Aromatase Inhibitor Musculoskeletal Syndrome and Bone Loss: a Review of
   the Current Literature
SO CURRENT ONCOLOGY REPORTS
LA English
DT Review
DE Aromatase inhibitor; Musculoskeletal complications; Cancer
   rehabilitation; Cancer treatment side effects
ID BREAST-CANCER SURVIVORS; INDUCED ARTHRALGIA; POSTMENOPAUSAL WOMEN;
   RISK-FACTORS; TRIAL; SYMPTOMS; PAIN; ANASTROZOLE; EXEMESTANE; LETROZOLE
AB Purpose of Review The study aims to review the literature regarding musculoskeletal complications of aromatase inhibitors and treatment options for these complications.
   Recent Findings Aromatase inhibitors are common medications to treat hormone receptor-positive breast cancer in postmenopausal women and have been shown to improve survival and prevent disease recurrence. However, 20-60% patients stop treatment prematurely due to side effects. Side effects include joint stiffness and pain, tendonitis, tendon tears, muscle pain, and carpal tunnel syndrome known as aromatase inhibitor musculoskeletal syndrome (AIMSS) as well as bone loss. Proposed mechanisms of AIMSS include decreased estrogen levels, inflammation, and genetic factors. Switching aromatase inhibitors, exercise, non-steroidal anti-inflammatory medications, duloxetine, acupuncture, prednisone, and bisphosphonates are some treatment options for this syndrome and will be discussed in more detail in this review.
   Summary Aromatase inhibitors are important in the treatment of hormone receptor-positive breast cancer in postmenopausal women. As we study the incidence of side effects of these medications including bone loss and AIMSS and determine the mechanisms of these symptoms and possible treatment options, we will decrease the incidence of patients discontinuing treatment prematurely and improve symptoms, quality of life, and survival in this patient population.
C1 [Holz, Sara Christensen] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53705 USA.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Holz, SC (corresponding author), Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53705 USA.
EM christensenholz@rehab.wisc.edu
OI Christensen Holz, Sara/0000-0002-7488-7287
CR Anand K, 2019, CURR ONCOL REP, V21, DOI 10.1007/s11912-019-0795-1
   Arem H, 2016, J CANCER SURVIV, V10, P654, DOI 10.1007/s11764-015-0511-6
   Bertolini E, 2011, JOINT BONE SPINE, V78, P62, DOI 10.1016/j.jbspin.2010.05.016
   Boing L, 2020, MATURITAS, V141, P71, DOI 10.1016/j.maturitas.2020.06.022
   Briot K, 2010, BREAST CANCER RES TR, V120, P127, DOI 10.1007/s10549-009-0692-7
   Bruzzese V, 2011, INT J IMMUNOPATH PH, V24, P1099, DOI 10.1177/039463201102400430
   Caprioli M, 2017, RMD OPEN, V3, DOI 10.1136/rmdopen-2017-000523
   Chao J, 2009, J RHEUMATOL, V36, P1087, DOI 10.3899/jrheum.080648
   Chung KY, 2022, PLAST RECONSTR SURG, V149, p445E, DOI 10.1097/PRS.0000000000008835
   Coleman R, 2014, ANN ONCOL, V25, P124, DOI 10.1093/annonc/mdu103
   Colleoni M, 2018, LANCET ONCOL, V19, P127, DOI 10.1016/S1470-2045(17)30715-5
   De Placido S, 2018, LANCET ONCOL, V19, P474, DOI 10.1016/S1470-2045(18)30116-5
   Din OS, 2010, BREAST CANCER RES TR, V120, P525, DOI 10.1007/s10549-010-0757-7
   Dowsett M, 2015, LANCET, V386, P1341, DOI 10.1016/S0140-6736(15)61074-1
   Eastell R, 2008, J CLIN ONCOL, V26, P1051, DOI 10.1200/JCO.2007.11.0726
   Henry NL, 2018, J CLIN ONCOL, V36, P326, DOI 10.1200/JCO.2017.74.6651
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Hyder T, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.713700
   Kubo M, 2012, ANTICANCER RES, V32, P2331
   Lustberg MB, 2018, BREAST CANCER RES TR, V167, P709, DOI 10.1007/s10549-017-4559-z
   Mao JJ, 2009, CANCER, V115, P3631, DOI 10.1002/cncr.24419
   Martens HA, 2007, RHEUMATOLOGY, V46, P1619, DOI 10.1093/rheumatology/kem213
   Mitsimponas N, 2018, CASE REP ONCOL, V11, P557, DOI 10.1159/000491874
   Morales L, 2007, BREAST CANCER RES TR, V104, P87, DOI 10.1007/s10549-006-9394-6
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Paulo TRS, 2019, HEALTH QUAL LIFE OUT, V17, DOI 10.1186/s12955-019-1090-4
   Pedersini R, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.11080
   Presant CA, 2007, CLIN BREAST CANCER, V7, P775, DOI 10.3816/CBC.2007.n.038
   Roberts KE, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013167.pub2
   Santa-Maria CA, 2018, BREAST CANCER RES TR, V171, P121, DOI 10.1007/s10549-018-4811-1
   Sestak I, 2008, LANCET ONCOL, V9, P866, DOI 10.1016/S1470-2045(08)70182-7
   Shen S, 2018, BREAST CANCER RES TR, V172, P603, DOI 10.1007/s10549-018-4946-0
   Sheng JY, 2019, BREAST CANCER RES TR, V176, P617, DOI 10.1007/s10549-019-05270-4
   Shin DJ, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000028786
   Tenti S, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21165625
   Wagner LI, 2018, BREAST CANCER RES TR, V169, P537, DOI 10.1007/s10549-018-4713-2
   Xu XQ, 2019, BREAST CANCER RES TR, V174, P785, DOI 10.1007/s10549-018-05086-8
   Yardley DA, 2016, BREAST CANCER-TARGET, V8, P73, DOI 10.2147/BCTT.S97963
   Zhu XY, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.745280
NR 40
TC 7
Z9 7
U1 1
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3790
EI 1534-6269
J9 CURR ONCOL REP
JI Curr. Oncol. Rep.
PD JUL
PY 2023
VL 25
IS 7
BP 825
EP 831
DI 10.1007/s11912-023-01413-5
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA LG1P9
UT WOS:001185540600001
PM 37052869
DA 2026-01-16
ER

PT J
AU Yurkovski, IL
   Andreazzoli, F
   Ben-Arye, E
   Attias, S
   Tadmor, T
AF Yurkovski, Ilana Levy
   Andreazzoli, Francesca
   Ben-Arye, Eran
   Attias, Samuel
   Tadmor, Tamar
TI Integrative Approaches in the Treatment of Patients Affected by Lymphoma
SO CURRENT ONCOLOGY REPORTS
LA English
DT Review
DE Integrative medicine; Lymphoma; Complementary medicine; Haemato-oncology
ID NON-HODGKIN-LYMPHOMA; CANCER-RELATED FATIGUE; VINCRISTINE-INDUCED
   NEUROPATHY; INDUCED PERIPHERAL NEUROPATHY; CHEMOTHERAPY-INDUCED NAUSEA;
   ORAL POLYPHENON E; VITAMIN-D LEVELS; B-CELL LYMPHOMA; RAI STAGE 0;
   ALTERNATIVE MEDICINE
AB Purpose of ReviewLymphoma is the most frequent hematological malignancy with wide disease spectrum of watchful waiting period, active treatment, survivorship, and palliative care. All these steps impose unmet needs in terms of prevention, symptom alleviation, or prognosis. Complementary and integrative medicine (CIM) is widely used by patients with lymphoma to cope with such issues. Here, we describe the different CIM modalities that may be effective and safe for the management of patients with lymphoma.Recent FindingsLow inflammatory diet and ginseng seem effective for lymphoma prevention. Pain and neuropathy may be improved using acupuncture, touch therapy and specific dietary supplements. Nausea/vomiting, fatigue, and insomnia may be relieved by acupuncture, mind-body, touch therapy, and certain dietary supplements. Vitamin D, curcumin, and some traditional medicine herbs may positively impact lymphoma prognosis. Finally, safety issues should be considered especially for the concomitant use of dietary supplements and lymphoma-directed therapies.SummaryCIM may be beneficial along the continuum of lymphoma management although safety concerns should be considered when used concomitantly with conventional therapy.
C1 [Yurkovski, Ilana Levy; Tadmor, Tamar] Bnai Zion Med Ctr, Rheumatol Unit, Golomb 47, Haifa 38041, Israel.
   [Yurkovski, Ilana Levy; Attias, Samuel] Bnai Zion Med Ctr, Complementary Med Serv, Hefa, Israel.
   [Yurkovski, Ilana Levy; Ben-Arye, Eran; Tadmor, Tamar] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
   [Andreazzoli, Francesca] Versilias Hosp, Dept Hematol, Camaiore, Italy.
   [Ben-Arye, Eran] Lin Carmel & Zebulun Med Ctr, Integrat Oncol Program, Oncol Serv, Clalit Hlth Serv, Haifa, Israel.
C3 Bnai Zion Medical Center; Bnai Zion Medical Center; Technion Israel
   Institute of Technology; Rappaport Faculty of Medicine; Clalit Health
   Services
RP Yurkovski, IL (corresponding author), Bnai Zion Med Ctr, Rheumatol Unit, Golomb 47, Haifa 38041, Israel.; Yurkovski, IL (corresponding author), Bnai Zion Med Ctr, Complementary Med Serv, Hefa, Israel.; Yurkovski, IL (corresponding author), Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
EM ilana.e.levy@gmail.com
CR Abad A. Namvaran Abbas, 2011, Chinese Journal of Natural Medicines, V9, P126, DOI 10.3724/SP.J.1009.2011.00126
   Abad Ali Namvaran Abbas, 2011, Chinese Journal of Natural Medicines, V9, P354, DOI 10.3724/SP.J.1009.2011.00354
   Afungchwi GM, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1719-y
   Almanza-Aguilera E, 2023, SEMIN CANCER BIOL, V95, P103, DOI 10.1016/j.semcancer.2023.08.001
   Alparslan GB, 2012, J AUST TRADIT-MED SO, V18, P15
   Amatya B, 2021, J REHABIL MED, V53, DOI 10.2340/16501977-2810
   Andreazzoli F, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24021732
   Atas U, 2023, NUTR CANCER, V75, P591, DOI 10.1080/01635581.2022.2142248
   Baysal M, 2021, NIGER J CLIN PRACT, V24, P1194, DOI 10.4103/njcp.njcp_429_20
   Ben-Arye E, 2022, IMPACT ACUPUNCTURE I
   Ben-Arye E, 2010, LEUKEMIA LYMPHOMA, V51, P1414, DOI 10.3109/10428194.2010.487622
   Bertrand KA, 2017, AM J CLIN NUTR, V106, P650, DOI 10.3945/ajcn.117.155010
   Borchmann S, 2019, J CLIN ONCOL, V37, P3528, DOI 10.1200/JCO.19.00985
   Bruns H, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aaa3230
   Chang YD, 2018, AM J HOSP PALLIAT ME, V35, P144, DOI 10.1177/1049909117695733
   Chen KW, 2002, J ALTERN COMPLEM MED, V8, P615, DOI 10.1089/107555302320825138
   Choi J, 2022, NUTRIENTS, V14, DOI 10.3390/nu14234982
   Cohen L, 2004, CANCER-AM CANCER SOC, V100, P2253, DOI 10.1002/cncr.20236
   Drake MT, 2010, J CLIN ONCOL, V28, P4191, DOI 10.1200/JCO.2010.28.6674
   Eikeland SA, 2021, ACTA ONCOL, V60, P911, DOI 10.1080/0284186X.2021.1917776
   El Iskandarani S, 2022, BLOOD REV, V56, DOI 10.1016/j.blre.2022.100985
   Fancher KM, 2020, CANCER CHEMOTH PHARM, V86, P507, DOI 10.1007/s00280-020-04137-6
   Felbel S, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010146.pub2
   Frenkel M, 2015, CURR ONCOL REP, V17, DOI 10.1007/s11912-015-0445-1
   Geyer HL, 2020, BLOOD, V135, P2354, DOI 10.1182/blood.2019003116
   Ghirardi O, 2005, ANTICANCER RES, V25, P2681
   Gupta Kush, 2021, Cancer Treat Res Commun, V26, P100278, DOI [10.1016/j.ctarc.2020.100278, 10.1016/j.ctarc.2020.100278]
   Habermann TM, 2009, AM J HEMATOL, V84, P795, DOI 10.1002/ajh.21554
   Hamilton AS, 2013, INTEGR CANCER THER, V12, P225, DOI 10.1177/1534735412449733
   Hathiramani S, 2021, J CANCER SURVIV, V15, P470, DOI 10.1007/s11764-020-00941-4
   Hohaus S, 2018, CANCER MED-US, V7, P270, DOI 10.1002/cam4.1166
   Huang Q, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.787816
   Hübner J, 2021, DTSCH ARZTEBL INT, V118, P654, DOI 10.3238/arztebl.m2021.0277
   Hutchinson K, 2015, LEUKEMIA LYMPHOMA, V56, P508, DOI 10.3109/10428194.2014.919633
   International Agency for Research on Cancer. World Health Organization, 2023, FACT SHEET: PCAOB Imposes Historic Sanctions on China-Based Audit Firms'
   Jang DK, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10020324
   Jiménez-Cortegana C, 2021, CANCERS, V13, DOI 10.3390/cancers13184622
   Jung JS, 2017, CASE REP ONCOL, V10, P515, DOI 10.1159/000472248
   Kaur Gurpreet, 2018, Int J Yoga, V11, P249, DOI [10.4103/ijoy.ijoy_17_18, 10.4103/ijoy.IJOY_17_18]
   Kayo T, 2024, J INTEGR COMPLEMENT, V30, P77, DOI 10.1089/jicm.2022.0710
   Kelly JL, 2015, J CLIN ONCOL, V33, P1482, DOI 10.1200/JCO.2014.57.5092
   Kelly JL, 2009, CANCER INVEST, V27, P942, DOI 10.3109/07357900902849632
   Kim K, 2018, EUR J ONCOL NURS, V33, P91, DOI 10.1016/j.ejon.2018.01.012
   Konstantinidis Theocharis I, 2019, Asian Pac J Cancer Prev, V20, P1487, DOI 10.31557/apjcp.2019.20.5.1487
   Kulling PM, 2017, EUR J HAEMATOL, V98, P187, DOI 10.1111/ejh.12818
   Kumagai T, 2007, LEUKEMIA RES, V31, P523, DOI 10.1016/j.leukres.2006.08.019
   Kutcher AM, 2022, WESTERN J NURS RES, V44, P169, DOI 10.1177/0193945921992538
   Lee S, 2021, EXPLORE-NY, V17, P265, DOI 10.1016/j.explore.2020.10.004
   Lemke EA, 2021, J ADV PRACT ONCOL, V12
   Li DH, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5558590
   Li WY, 2022, BMC INFECT DIS, V22, DOI 10.1186/s12879-022-07338-x
   Li XX, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1060783
   Liang H, 2023, INTEGR CANCER THER, V22, DOI 10.1177/15347354221147515
   Liu WP, 2020, CANCER MED-US, V9, P3765, DOI 10.1002/cam4.3037
   Ma Y., 2022, FRONT  ONCOL, V12, P1
   Mahurin HM, 2021, COMPLEMENT THER MED, V61, DOI 10.1016/j.ctim.2021.102762
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Marx W, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080867
   Marx W, 2017, CRIT REV FOOD SCI, V57, P141, DOI 10.1080/10408398.2013.865590
   Matsukawa T, 2020, ANN HEMATOL, V99, P2859, DOI 10.1007/s00277-020-04262-5
   Mora DC, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03537-w
   Nagata A, 2020, HEMATOL ONCOL, V38, P309, DOI 10.1002/hon.2732
   Nakamura N, 2022, LEUKEMIA LYMPHOMA, V63, P1323, DOI 10.1080/10428194.2021.2020777
   Nath K, 2022, TRANSPL CELL THER, V28, DOI 10.1016/j.jtct.2022.08.001
   Ni F, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21570-z
   Okolo ON, 2019, CURR HEMATOL MALIG R, V14, P328, DOI 10.1007/s11899-019-00526-8
   Pradhan P, 2023, J NUTR, V153, P1170, DOI 10.1016/j.tjnut.2023.02.032
   Psaltopoulou T, 2018, NUTR CANCER, V70, P821, DOI 10.1080/01635581.2018.1490444
   Rambod M, 2019, EUR J ONCOL NURS, V43, DOI 10.1016/j.ejon.2019.101678
   Hosnijeh FS, 2021, INT J CANCER, V148, P2115, DOI 10.1002/ijc.33369
   Samuels N, 2020, PHARMACEUTICALS-BASE, V13, DOI 10.3390/ph13120455
   Sands S, 2017, SUPPORT CARE CANCER, V25, P701, DOI 10.1007/s00520-016-3441-6
   Sarisoy P, 2020, HOLIST NURS PRACT, V34, P345, DOI 10.1097/HNP.0000000000000412
   Sato T, 2015, MOL MED REP, V12, P6215, DOI 10.3892/mmr.2015.4137
   Satoh T, 2016, J PHARM PHARM SCI, V19, P188, DOI 10.18433/J3MS5C
   Schloss JM, 2017, SUPPORT CARE CANCER, V25, P195, DOI 10.1007/s00520-016-3404-y
   Sezgin MG, 2022, SUPPORT CARE CANCER, V30, P8733, DOI 10.1007/s00520-022-07198-w
   Shan SN, 2023, SUPPORT CARE CANCER, V31, DOI 10.1007/s00520-023-07926-w
   Shanafelt TD, 2013, CANCER-AM CANCER SOC, V119, P363, DOI 10.1002/cncr.27719
   Shanafelt TD, 2009, J CLIN ONCOL, V27, P3808, DOI 10.1200/JCO.2008.21.1284
   Shivappa N, 2017, CANCER CAUSE CONTROL, V28, P791, DOI 10.1007/s10552-017-0905-z
   Solans M, 2020, EUR J NUTR, V59, P813, DOI 10.1007/s00394-019-01947-0
   Solans M, 2019, INT J CANCER, V145, P122, DOI 10.1002/ijc.32091
   Solimini AG, 2016, CANCER CAUSE CONTROL, V27, P595, DOI 10.1007/s10552-016-0745-2
   Stephenson NLN, 2007, ONCOL NURS FORUM, V34, P127, DOI 10.1188/07.ONF.127-132
   Tabatabaee Amir, 2016, Med Arch, V70, P142, DOI [10.5455/medarh.2016.70.142-147, 10.5455/medarh.2016.70.142-147]
   Talib WH, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.905658
   Tan BL, 2019, MOLECULES, V24, DOI 10.3390/molecules24142527
   Tao YX, 2021, FUTURE ONCOL, V17, P1825, DOI 10.2217/fon-2020-0914
   Tretli S, 2012, CANCER CAUSE CONTROL, V23, P363, DOI 10.1007/s10552-011-9885-6
   Vargas-Roman K, 2022, J CLIN MED, V11
   Viscuse PV, 2017, CURR OPIN ONCOL, V29, P235, DOI 10.1097/CCO.0000000000000376
   Wang HN, 2018, CHEM-BIOL INTERACT, V281, P11, DOI 10.1016/j.cbi.2017.12.017
   Wang XS, 2002, J CLIN ONCOL, V20, P1319, DOI 10.1200/JCO.20.5.1319
   Weinhold KR, 2023, NUTR CANCER, V75, P937, DOI 10.1080/01635581.2023.2173259
   Wu T, 2015, J EXP CLIN CANC RES, V34, DOI 10.1186/s13046-015-0133-x
   Wu WC, 2023, CANCER MED-US, V12, P9439, DOI 10.1002/cam4.5706
   Yang S, 2010, CLIN CANCER RES, V16, P4755, DOI 10.1158/1078-0432.CCR-10-0883
   Yeh ML, 2016, EUR J ONCOL NURS, V23, P81, DOI 10.1016/j.ejon.2016.05.003
   Zhang W, 2020, BIOCHEM BIOPH RES CO, V524, P70, DOI 10.1016/j.bbrc.2019.12.129
   Zhang Y., 2021, FRONT ONCOL, V11, P1
   Zhang Y, 2018, SUPPORT CARE CANCER, V26, P415, DOI 10.1007/s00520-017-3955-6
   Zhang YJ, 2022, HEMATOLOGY, V27, P653, DOI 10.1080/16078454.2022.2078040
   Zhang YY, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000033939
NR 104
TC 5
Z9 5
U1 2
U2 9
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3790
EI 1534-6269
J9 CURR ONCOL REP
JI Curr. Oncol. Rep.
PD DEC
PY 2023
VL 25
IS 12
BP 1523
EP 1534
DI 10.1007/s11912-023-01476-4
EA DEC 2023
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA CE8P5
UT WOS:001115083700001
PM 38060095
DA 2026-01-16
ER

PT J
AU Bullen, A
   Awdishu, L
   Lester, W
   Moore, T
   Trzebinska, D
AF Bullen, Alexander
   Awdishu, Linda
   Lester, Wendy
   Moore, Teri
   Trzebinska, Danuta
TI Effect of Acupuncture or Massage on Health-Related Quality of Life of
   Hemodialysis Patients
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE acupuncture; massage; psychological; anxiety; renal dialysis
ID STAGE RENAL-DISEASE; CHRONIC KIDNEY-DISEASE; RESTLESS LEGS SYNDROME;
   UNITED-STATES; DIALYSIS PATIENTS; SYMPTOM MANAGEMENT; CANCER-PATIENTS;
   SLEEP QUALITY; FOLLOW-UP; PAIN
AB Objective: The purpose of this study was to evaluate the effect of acupuncture and massage on health-related quality of life (HR-QOL) among end stage renal disease (ESRD) patients. Design: Pre-post test design. Setting: A hemodialysis (HD) unit located in a university hospital. Intervention: Participants were given the option to choose between 20min sessions of massage or acupuncture therapy once a week for 8 weeks by licensed acupuncturists and massage therapists while undergoing their usual HD session in the University of California, San Diego Chronic HD unit. Outcome measures: Participants were asked to complete pre- and postintervention surveys, which consisted of the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health Short Form and a Generalized Anxiety Disorder 7-item Scale. Results: A total of 101 patients were included in this study. The average age was 57.6 (standard deviation: 14.5) dialysis vintage 7.5 years, 58% patients were male and the most common etiology of ESRD was diabetic nephropathy (45%). Patients had multiple comorbidities as can be expected for this population with the most common being hypertension (94%), diabetes mellitus (53%), and cardiovascular disease (53%). In this brief intervention study, we were able to find a trend toward improvement in overall HR-QOL as determined by the PROMIS score (p=0.08). PROMIS mental raw score improved with intervention, which was statistically significant (p=0.034). Conclusion: Use of complementary therapies such as massage and acupuncture during HD may contribute toward improvement of HR-QOL and thus should be considered when addressing overall health status of these patients.
C1 [Bullen, Alexander; Lester, Wendy; Moore, Teri; Trzebinska, Danuta] Univ Calif San Diego, Div Nephrol, San Diego, CA 92103 USA.
   [Awdishu, Linda] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Trzebinska, D (corresponding author), Univ Calif San Diego, Sch Med, Div Nephrol, 200 West Arbor Dr 8781, San Diego, CA 92103 USA.
EM dtrzebinska@ucsd.edu
RI Awdishu, Linda/AAH-1427-2019
OI Awdishu, Linda/0000-0002-3187-3264
CR Chatterjee SS, 2015, J NEUROSCI RURAL PRA, V6, P160, DOI 10.4103/0976-3147.153219
   Collins AJ, 2010, AM J KIDNEY DIS, V55, pVI, DOI 10.1053/j.ajkd.2009.10.009
   Cukor D, 2008, CLIN J AM SOC NEPHRO, V3, P1752, DOI 10.2215/CJN.01120308
   Davison SN, 2015, CLIN J AM SOC NEPHRO, V10, P350, DOI 10.2215/CJN.00600115
   Davison SN, 2014, SEMIN DIALYSIS, V27, P188, DOI 10.1111/sdi.12196
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Diaz-Buxo JA, 2000, AM J KIDNEY DIS, V35, P293, DOI 10.1016/S0272-6386(00)70339-8
   Diemont WL, 2000, AM J KIDNEY DIS, V35, P845, DOI 10.1016/S0272-6386(00)70254-X
   Gerogianni GK., 2013, Health Sci. J, V7, P169, DOI DOI 10.1016/j.ijnurstu.2014.11.002
   Hashemi SH, 2015, NURS MIDWIFERY STUD, V4, DOI 10.17795/nmsjournal29617
   Hedayati SS, 2017, JAMA-J AM MED ASSOC, V318, P1876, DOI 10.1001/jama.2017.17131
   Hmwe NTT, 2015, INT J NURS STUD, V52, P509, DOI 10.1016/j.ijnurstu.2014.11.002
   Hoffmann F, 2011, NEPHROL DIAL TRANSPL, V26, P1634, DOI 10.1093/ndt/gfq609
   Kalantar-Zadeh K, 2003, KIDNEY INT, V63, P793, DOI 10.1046/j.1523-1755.2003.00803.x
   Kim KH, 2016, COCHRANE DATABASE SY, V2016
   Kim KH, 2013, ACUPUNCT MED, V31, P228, DOI 10.1136/acupmed-2012-010257
   Kim KH, 2011, J ALTERN COMPLEM MED, V17, P741, DOI 10.1089/acm.2010.0206
   Kimmel PL, 2017, J AM SOC NEPHROL, V28, P3658, DOI 10.1681/ASN.2017010098
   Ma TKW, 2016, NEPHROLOGY, V21, P639, DOI 10.1111/nep.12742
   Mapes DL, 2003, KIDNEY INT, V64, P339, DOI 10.1046/j.1523-1755.2003.00072.x
   Mastnardo Diane, 2016, Int J Ther Massage Bodywork, V9, P3, DOI 10.3822/ijtmb.v9i2.305
   Murtagh FEM, 2007, ADV CHRONIC KIDNEY D, V14, P82, DOI 10.1053/j.ackd.2006.10.001
   O'Connor NR, 2012, AM FAM PHYSICIAN, V85, P705
   Özdemir G, 2013, INT J NURS PRACT, V19, P265, DOI 10.1111/ijn.12066
   Palmer SC, 2016, COCHRANE DB SYST REV, V2016
   Romeo MJ, 2015, EXPLORE-NY, V11, P357, DOI 10.1016/j.explore.2015.06.001
   Saletu M, 2002, EUR ARCH PSY CLIN N, V252, P185, DOI 10.1007/s00406-002-0380-7
   Saran R, 2017, AM J KIDNEY DIS, V69, DOI 10.1053/j.ajkd.2016.12.004
   Shariati A, 2012, COMPLEMENT THER MED, V20, P417, DOI 10.1016/j.ctim.2012.08.001
   Su DJ, 2011, J HEALTH CARE POOR U, V22, P296, DOI 10.1353/hpu.2011.0002
   Tas D, 2014, ASIAN PAC J CANCER P, V15, P3139, DOI 10.7314/APJCP.2014.15.7.3139
   Thomas Z, 2017, CLIN J AM SOC NEPHRO, V12, P2008, DOI 10.2215/CJN.03900417
   Thompson LMA, 2015, J ACUPUNCT MERIDIAN, V8, P127, DOI 10.1016/j.jams.2015.04.002
   Unal KS, 2016, COMPLEMENT THER CLIN, V24, P139, DOI 10.1016/j.ctcp.2016.06.004
NR 34
TC 13
Z9 15
U1 1
U2 34
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD NOV
PY 2018
VL 24
IS 11
BP 1069
EP 1075
DI 10.1089/acm.2018.0030
EA MAY 2018
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA HA2KF
UT WOS:000434708700001
PM 29851511
DA 2026-01-16
ER

PT J
AU Narayanan, S
   Liu, WL
   Lopez, G
   Fellman, B
   Reddy, A
   Subbiah, IM
   Cohen, L
   Bruera, E
AF Narayanan, Santhosshi
   Liu, Wenli
   Lopez, Gabriel
   Fellman, Bryan
   Reddy, Akhila
   Subbiah, Ishwaria M.
   Cohen, Lorenzo
   Bruera, Eduardo
TI Practice Patterns on the Incorporation of Integrative Medicine Into the
   Oncologic Care of Patients With Cancer
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE integrative oncology; complementary and alternative treatments; cancer;
   integrative medicine; patient reported outcomes; implementation research
ID CONSULTATIONS; COMPLEMENTARY
AB Background: With rising interest in complementary approaches to symptom management, awareness of real-world practice patterns in the incorporation of integrative oncology (IO) into cancer care is limited. Therefore, we examined the reasons for referral, symptom burdens, and clinical outcomes for cancer patients who underwent initial IO consultations.Methods: The records of adult patients with cancer who underwent initial outpatient IO consultations at our cancer center for a representative 10-day period at the start of each month for 12 months starting January 1, 2017, were reviewed retrospectively. Patient demographic and medical characteristics and outpatient IO consultation details, including patient-reported outcome measures of symptom burden, were extracted. Descriptive summary statistics and logistic regression were used to analyze the data.Results: Among the 473 study patients, 71% were women, breast cancer (42%) was the most common cancer type, and 31% had metastatic cancer. Referring clinicians listed an integrative approach (57%) as the most common reason for referral, followed by diet (26%), pain (19%), discussion of herbs and supplements (18%), and stress (18%). In comparison, patients listed their primary concerns as diet (16%), pain (15%), and an integrative approach to overall health (11%). After the IO consultations, the highest likelihood of subsequent recommendations were acupuncture for hot flashes (odds ratio [OR], P = .002) or peripheral neuropathy (OR = 6.59, P < .001), oncology massage for pain (OR = 3.04, P < .001), psychology referral for patient's self-reported anxiety (OR = 2.35, P < .001), and mind-body therapies for stress (OR = 2.57, P < .001).Conclusion: Cancer patients' top concerns regarding IO consultation may not always match providers' reasons for referral. Longitudinal data analysis is needed to determine the effect of integrative interventions on symptom burden.
C1 [Narayanan, Santhosshi; Liu, Wenli; Lopez, Gabriel; Fellman, Bryan; Reddy, Akhila; Subbiah, Ishwaria M.; Cohen, Lorenzo; Bruera, Eduardo] Univ Texas MD Anderson Canc Ctr, Houston, TX USA.
   [Narayanan, Santhosshi] Univ Texas MD Anderson Canc, Dept Palliat Rehabil & Integrat Med, Unit 1414, 1400 Pressler St,1515 Holcombe Blvd, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; UTMD Anderson Cancer Center
RP Narayanan, S (corresponding author), Univ Texas MD Anderson Canc, Dept Palliat Rehabil & Integrat Med, Unit 1414, 1400 Pressler St,1515 Holcombe Blvd, Houston, TX 77030 USA.
EM snarayanan2@mdanderson.org
RI ; Subbiah, Ishwaria/AAW-1733-2021
OI Lopez, Gabriel/0000-0002-3685-0280; 
FU Duncan Family Institute for Cancer Prevention and Risk Assessment
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Editorial
   support was provided by Bryan Tutt and Donald Norwood, Scientific
   Editors, Research Medical Library. This research was funded in part by
   the Duncan Family Institute for Cancer Prevention and Risk Assessment.
CR ASCO in Action, 2018, National Survey Reveals Surprising Number of Americans Believe Alternative Therapies Can Cure Cancer
   Bao T, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.0681
   Ben-Arye E, 2021, SUPPORT CARE CANCER, V29, P6155, DOI 10.1007/s00520-021-06205-w
   Berger Ann M, 2015, J Natl Compr Canc Netw, V13, P1012
   Bruera E, 1991, J Palliat Care, V7, P6
   Davis EL, 2012, ONCOLOGIST, V17, P1475, DOI 10.1634/theoncologist.2012-0223
   Falkensteiner M., 2011, ISRN Nurs, P2011
   Garcia MK, 2015, CANCER-AM CANCER SOC, V121, P3948, DOI 10.1002/cncr.29630
   Grant SJ., 2021, INTEGR CANCER THER, V20
   Hays RD, 2009, QUAL LIFE RES, V18, P873, DOI 10.1007/s11136-009-9496-9
   Hui D, 2015, CANCER-AM CANCER SOC, V121, P3027, DOI 10.1002/cncr.29437
   Lee RT, 2014, J CLIN ONCOL, V32, P4095, DOI 10.1200/JCO.2014.55.8676
   Lopez G, 2017, J CANCER, V8, P395, DOI 10.7150/jca.17506
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Mao JJ, 2023, JCO ONCOL PRACT, V19, P45, DOI 10.1200/OP.22.00622
   Narayanan S, 2021, INTEGR CANCER THER, V20, DOI 10.1177/1534735421999101
   National Comprehensive Cancer Center, Flash Update: NCCN Guidelines and NCCN Compendium for Antiemesis
   Paterson C, 2007, COMPLEMENT THER MED, V15, P38, DOI 10.1016/j.ctim.2006.03.006
   Witt Claudia M., 2017, Journal of the National Cancer Institute Monographs, P3, DOI [10.1093/jncimonographs/lgx012, 10.1093/jncimonographs/lgx012]
   Yun Hyeongjun, 2017, Journal of the National Cancer Institute Monographs, P29, DOI [10.1093/jncimonographs/lgx004, 10.1093/jncimonographs/lgx004]
   Zia Farah Z., 2017, Journal of the National Cancer Institute Monographs, P68, DOI [10.1093/jncimonographs/lgx005, 10.1093/jncimonographs/lgx005]
NR 21
TC 3
Z9 3
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2023
VL 22
AR 15347354231213045
DI 10.1177/15347354231213045
PG 7
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA CC8Q6
UT WOS:001123146900001
PM 37978821
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ma, MJ
   Zhang, LQ
   Wang, XL
AF Ma, Mengjie
   Zhang, Liuqiao
   Wang, Xiangli
TI Effect of auricular point pressing therapy on hyperplasia of mammary
   glands A protocol for systematic review and meta-analysis
SO MEDICINE
LA English
DT Review
DE auricular point pressing; hyperplasia of mammary glands; meta-analysis;
   systematic review
ID ACUPRESSURE; PAIN
AB Background: In recent years, with the accelerated pace of life, diet, environmental problems occur frequently. External factors are easily to cause endocrine disorders and hormone sensitivity of breast tissue, which can lead to mammary hyperplasia. The incidence rate of hyperplasia of mammary glands is increasing year by year, and the age of onset is also getting lower and lower. If not treated in time, there is a crisis of breast cancer. Clinical studies have found that auricular point pressing therapy is widely used in clinical treatment of mammary hyperplasia recently, but the efficacy of massage in the treatment of mammary hyperplasia has not been systematically reviewed. The purpose of this study is to explore the efficacy, safety and effectiveness of auricular point pressing therapy in the treatment of hyperplasia of mammary glands. Methods: We will search PubMed, Web of Science, Cochrane Library, EMBASE, Wan fang Database, Chinese Scientific Journal Database, CNKI, VIP, and Chinese Biomedical Literature Database. The retrieval date was January 10, 2021. RevMan 5.3 software was used to evaluate the quality and risk of included studies. The efficacy, recurrence rate, and symptom score of breast hyperplasia were analyzed, and the results were observed and measured. Results: This study will be from the clinical efficiency, improvement rate, pain symptoms disappear rate, tumor size improvement rate, and other aspects of the existing evidence for a high quality synthesis, as well as auricular point pressing therapy adverse events. Conclusion: the conclusion of this review will provide the basis for judging whether auricular point pressing therapy is safe and effective in the treatment of hyperplasia of mammary glands. Ethics and dissemination: This systematic will evaluate the effectiveness and safety of auricular point pressing therapy in the treatment of hyperplasia of mammary glands. As all data used in this systematic review and meta-analysis have been published, ethical approval is not required for this review. Protocol registration number: INPLASY202110028.
C1 [Ma, Mengjie; Zhang, Liuqiao; Wang, Xiangli] Henan Univ Tradit Chinese Med, 156 Jinshui East Rd, Zhengzhou, Henan, Peoples R China.
C3 Henan University of Traditional Chinese Medicine
RP Zhang, LQ (corresponding author), Henan Univ Tradit Chinese Med, Affiliated Hosp 2, Henan Hosp Tradit Chinese Med, 6 Dongfeng Rd, Zhengzhou, Henan, Peoples R China.
EM 2553868697@qq.com
FU Special Project of Traditional Chinese Medicine Research in Henan
   Province [2019ZY2148]
FX This work was financially supported by the Special Project of
   Traditional Chinese Medicine Research in Henan Province (Grant number:
   2019ZY2148).
CR Chai L., 2020, PAIN MANAG NURS, V20, P17
   Chen SG., 1997, ORTHODOX SURG, P436
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Gao JL, 2020, EUR J CARDIOVASC NUR, V19, P20, DOI 10.1177/1474515119876778
   Han Q, 2020, J ADV NURS, V76, P1924, DOI 10.1111/jan.14375
   Jie Y, 2021, CHIN J TRADIT CHIN M, V1, P1005
   Jin L., 2012, HEILONGJIANG TRADIT, V41, P62
   KAWAKITA K, 1991, AM J CHINESE MED, V19, P199, DOI 10.1142/S0192415X91000272
   Ko YL, 2016, J CLIN NURS, V25, P332, DOI 10.1111/jocn.13053
   Kuo HC, 2018, RES NURS HEALTH, V41, P469, DOI 10.1002/nur.21885
   Li Wan-shan, 2011, Zhongguo Zhen Jiu, V31, P349
   Yang YL, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/1618767
   Ye Yu-Fei, 2019, Zhongguo Zhen Jiu, V39, P605, DOI 10.13703/j.0255-2930.2019.06.010
   Yeh CH, 2020, TRIALS, V21, DOI 10.1186/s13063-019-4016-x
   Yeh CH, 2012, J ALTERN COMPLEM MED, V18, P334, DOI 10.1089/acm.2011.0102
   Yu J, 2017, J ACUPUNCT TUINA SCI, V15, P219, DOI 10.1007/s11726-017-1004-0
   Zhang Z, 2012, SHANGHAI J ACUPUNCT, V31, P730
   Zhao X., 2020, J GUANGZHOU UNIVERS, V37, P1259
   Zhou M., 2016, HUBEI J TRADIT CHIN, V38, P76
   Zhu D, 2019, WORLD J INTEGR TRADI, V14, P292
NR 20
TC 4
Z9 6
U1 1
U2 43
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR 2
PY 2021
VL 100
IS 13
AR e24875
DI 10.1097/MD.0000000000024875
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA SO4RD
UT WOS:000658960700012
PM 33787577
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Jiang, YY
   Li, X
   Hu, FX
   Wang, DN
   Zang, JM
   Liu, ZL
   Xu, F
   Cui, WQ
AF Jiang, Yi-Yang
   Li, Xue
   Hu, Feng-Xian
   Wang, Dan-Ni
   Zang, Ji-Miao
   Liu, Zhen-Ling
   Xu, Fei
   Cui, Wen-Qiang
TI Electroacupuncture alleviates chemotherapy-induced peripheral neuropathy
   and anxiety by reducing TRPC6/PKC-dependent activation of glutamatergic
   neurons in the paraventricular thalamic nucleus
SO NEUROSCIENCE
LA English
DT Article
DE Electroacupuncture; Chemotherapeutic neuropathy; Anxiety;
   Paraventricular thalamic nucleus; Cisplatin
ID CALCIUM; TRPC6; FACILITATION; RECEPTORS; CHANNELS; DAMAGE
AB Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and dose-limiting side effect of neurotoxic cancer treatments, generally alongside anxiety disorders. The paraventricular thalamic nucleus (PVT), as an integrative node of sensory perceptions and emotional reactions, remains unclear in CIPN modulation. This study aimed to investigate the role of PVT in CIPN and reveal the mechanisms through which electroacupuncture (EA) alleviates CIPN. In this study, a CIPN mouse model with emotional disorders was established through the intervention of cisplatin for 21 d, which was validated by the von Frey test, adhesive removal test, open-field test and elevated plus-maze test. Data showed that the cisplatin-related CIPN was characterized by the increase of calcium channel proteins TRPC6 and PKC, as well as the activation of glutamatergic neurons in PVT. Inhibition of TRPC6 and PKC using SAR7334 significantly hindered sensory neuron damage and the loss of intra-epidermal nerve fibers (IENFs) and Merkel cells, while improving anxiety-like behaviors. EA treatment ameliorated the symptoms of CIPN, including neuropathic pain, impairment of cutaneous sensation, and loss of IENFs and Merkel cells in the acral skin, which exhibited similar effects of SAR7334. Mechanically, EA treatment significantly inhibited TRPC6 activation, reducing the Ca2+ influx and attenuating p-PKC level, thereby decreasing the release of excitatory neurotransmitter glutamate in the PVT. Our findings revealed a novel mechanism through which calcium influx-mediated glutamatergic neuron activation in PVT participated in the CIPN and provided evidence that TRPC6/PKC may be potent targets for the EA effect.
C1 [Jiang, Yi-Yang; Hu, Feng-Xian; Wang, Dan-Ni; Zang, Ji-Miao; Liu, Zhen-Ling] Shandong Univ Tradit Chinese Med, Sch Clin Med 1, Jinan 250014, Peoples R China.
   [Li, Xue] Shandong Univ Tradit Chinese Med, Sch Acupuncture & Tuina, Jinan 250014, Peoples R China.
   [Xu, Fei] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Resp & Crit Care Med, 16369 Jingshi Rd, Jinan 250014, Peoples R China.
   [Cui, Wen-Qiang] Shandong Univ Tradit Chinese Med, Dept Neurol, Affiliated Hosp, 16369 Jingshi Rd, Jinan 250014, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University of Traditional
   Chinese Medicine; Shandong University of Traditional Chinese Medicine
RP Xu, F (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Resp & Crit Care Med, 16369 Jingshi Rd, Jinan 250014, Peoples R China.; Cui, WQ (corresponding author), Shandong Univ Tradit Chinese Med, Dept Neurol, Affiliated Hosp, 16369 Jingshi Rd, Jinan 250014, Peoples R China.
EM Fei_Xu1012@126.com; wqcui16@fudan.edu.cn
FU Shandong Province Taishan Scholar Project [tsqn202211355,
   tsqn202306393]; China Postdoctoral Science Foundation [2023T160726,
   2023M733914]
FX Funding This study was supported by the Shandong Province Taishan
   Scholar Project [grant numbers tsqn202211355 and tsqn202306393] and the
   China Postdoctoral Science Foundation [grant numbers 2023T160726 and
   2023M733914] .
CR Airaksinen MS, 1996, NEURON, V16, P287, DOI 10.1016/S0896-6273(00)80047-1
   Areti A, 2014, REDOX BIOL, V2, P289, DOI 10.1016/j.redox.2014.01.006
   Bentzen AG, 2013, ACTA ONCOL, V52, P736, DOI 10.3109/0284186X.2013.770599
   Bu F, 2015, SCI REP-UK, V5, DOI 10.1038/srep15945
   Chang S, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aax1342
   Chu WG, 2025, ADV SCI, DOI 10.1002/advs.202501182
   Cui WQ, 2020, J PAIN, V21, P238, DOI 10.1016/j.jpain.2019.08.012
   Du WL, 2010, J CLIN INVEST, V120, P3480, DOI 10.1172/JCI43165
   Duan LQ, 2025, BRAIN RES BULL, V222, DOI 10.1016/j.brainresbull.2025.111235
   Estadella I, 2025, SCI SIGNAL, V18, DOI 10.1126/scisignal.ado8924
   Fechner S, 2018, NEURON, V100, P1272, DOI 10.1016/j.neuron.2018.12.001
   Florczak A, 2020, J NANOBIOTECHNOL, V18, DOI 10.1186/s12951-020-00734-y
   Gao C, 2020, NAT NEUROSCI, V23, P217, DOI 10.1038/s41593-019-0572-3
   Garland SN, 2019, JNCI-J NATL CANCER I, V111, P1323, DOI 10.1093/jnci/djz050
   Hunt JL, 2005, J AM SOC NEPHROL, V16, P1593, DOI 10.1681/ASN.2004080679
   Jia YZ, 2022, FRONT MOL NEUROSCI, V15, DOI 10.3389/fnmol.2022.979483
   Kawata D, 2017, MOL THER-METH CLIN D, V6, P91, DOI 10.1016/j.omtm.2017.06.004
   Li D, 2025, NEURON, V113, P2310, DOI 10.1016/j.neuron.2025.04.019
   Li S, 2012, BRAIN STRUCT FUNCT, V217, P257, DOI 10.1007/s00429-011-0360-7
   Li SH, 2024, NEUROSCIENCE, V537, P151, DOI 10.1016/j.neuroscience.2023.11.033
   Li YY, 2025, CHIN MED-UK, V20, DOI 10.1186/s13020-024-01023-8
   Li YY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235917
   Liang HY, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16198-5
   Liang SH, 2020, J NEUROSCI, V40, P7837, DOI 10.1523/JNEUROSCI.2487-19.2020
   Liu GH, 2025, NEUROCHEM RES, V50, DOI 10.1007/s11064-025-04401-2
   Liu X, 2024, BRAIN BEHAV, V15, DOI 10.1002/brb3.70218
   Ma X, 2022, ANESTH ANALG, V134, P204, DOI 10.1213/ANE.0000000000005768
   Maksimovic S, 2014, NATURE, V509, P617, DOI 10.1038/nature13250
   Maksimovic S, 2013, ANN NY ACAD SCI, V1279, P13, DOI 10.1111/nyas.12057
   Perez SM, 2018, J NEUROSCI, V38, P10607, DOI 10.1523/JNEUROSCI.2629-16.2018
   Podratz JL, 2011, NEUROBIOL DIS, V41, P661, DOI 10.1016/j.nbd.2010.11.017
   Rosethorne EM, 2008, BIOCHEM PHARMACOL, V75, P942, DOI 10.1016/j.bcp.2007.10.015
   Sahu G, 2017, J NEUROSCI, V37, P11255, DOI 10.1523/JNEUROSCI.0967-17.2017
   Seo SY, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084037
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Shi J, 2004, J PHYSIOL-LONDON, V561, P415, DOI 10.1113/jphysiol.2004.075051
   Tang QQ, 2023, NEUROPSYCHOPHARMACOL, DOI 10.1038/s41386-023-01748-4
   Tao ZR, 2025, CANCER LETT, V611, DOI 10.1016/j.canlet.2024.217433
   Wan KX, 2025, CHIN MED-UK, V20, DOI 10.1186/s13020-025-01083-4
   Xie JD, 2017, J BIOL CHEM, V292, P20644, DOI 10.1074/jbc.M117.818476
   Yeh ML, 2024, BMC COMPLEMENT MED, V24, DOI 10.1186/s12906-024-04603-1
   Zernov N, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242015415
   Zhang MC, 2020, J CLIN INVEST, V130, P2953, DOI 10.1172/JCI123159
   Zhao ZQ, 2008, PROG NEUROBIOL, V85, P355, DOI 10.1016/j.pneurobio.2008.05.004
   Zhou J, 2008, NAT NEUROSCI, V11, P741, DOI 10.1038/nn.2127
NR 45
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD JAN 9
PY 2026
VL 592
BP 97
EP 110
DI 10.1016/j.neuroscience.2025.11.031
EA JAN 2025
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA N4150
UT WOS:001631550600002
PM 41290068
DA 2026-01-16
ER

PT J
AU Angeletti, C
   Angeletti, PM
   Paesani, M
   Guetti, C
   Gyra, A
   Perseo, G
   Ciccozzi, A
   Marinangeli, F
   Altobelli, E
AF Angeletti, Chiara
   Angeletti, Paolo Matteo
   Paesani, Martina
   Guetti, Cristiana
   Gyra, Aglaia
   Perseo, Gianluca
   Ciccozzi, Alessandra
   Marinangeli, Franco
   Altobelli, Emma
TI Assessment of Pain and Associated Comorbidities: A Survey of Real Life
   Experiences Among Nurses in Italy
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE pain management; nurse education; psychological comorbidities
ID MENTAL-HEALTH; AMERICAN-SOCIETY; UNITED-STATES; NECK PAIN; DISORDERS;
   PREVALENCE; MANAGEMENT; EPIDEMIOLOGY; METAANALYSIS; EDUCATION
AB Purpose: Pain is a symptom that should be evaluated along with its comorbidities in order to plan an effective holistic treatment strategy involving specific pharmacological interventions, side effect management, psychological support, control of therapeutic effects over time, and dialogue with the patient and their relatives. In this holistic process of caring for patients with pain, nurses play a central role as they deal with suffering patients directly and continuously. The purpose of this study was to evaluate the types of pain identified by nurses in their daily clinical practice and the associated comorbidities (anamnestic history taking) by geographical region and to evaluate the pharmacological strategies used.
   Methods: A cross-sectional survey was performed among 696 registered nurses in Italy. Data were collected using an online questionnaire.
   Results: There was a significant difference between geographical regions in terms of reports of acute and chronic pain: acute pain was more frequently reported in the South (63.5%), while chronic pain was more frequent in the Central region (32.3%; p=0.0008). Additionally, chronic oncological pain was more frequent in the Northeast (29.6%), while chronic nononcological pain was more frequently reported in the Central region (33.9%; p=0.0001). The underlying pain disorders reported were also different between geographical regions; rheumatic pain (21.8%) and neurological pain (18.6%) were more frequent in the Central region, while musculoskeletal pain was significantly more frequent in the South (43.4%; p=0.004). Anxiety, sleep disorders and somatization were found in acute pain (60.82%, 43.56% and 53.12%), while depression and mood disorders were more frequently detected in chronic pain condition (p<0.001).
   Conclusion: Our study showed differences among Italian regions in pain assessment. Specific education on pain management nursing is essential for nurses. Promotion of optimal nursing care for people affected by pain is the main focus of pain management nursing. Nowadays, nurses should focus on personalized complex care and research in order to improve the patient's quality of life.
C1 [Angeletti, Chiara; Paesani, Martina; Perseo, Gianluca] Civil Hosp G Mazzini Teramo, Operat Unit Anaesthesiol Intens Care & Pain Med, Teramo, Italy.
   [Angeletti, Paolo Matteo; Gyra, Aglaia; Ciccozzi, Alessandra; Marinangeli, Franco] Univ Aquila, Dept Life Hlth & Environm Sci, Laquila, Italy.
   [Guetti, Cristiana] Azienda Osped Univ Careggi, Emergency Dept, Intens Care Unit, Florence, Italy.
   [Guetti, Cristiana] Azienda Osped Univ Careggi, Reg ECMO Referral Ctr, Florence, Italy.
   [Altobelli, Emma] Univ Aquila, Dept Life Hlth & Environm Sci, Epidemiol & Biostat Unit, AUSL Teramo, Laquila, Italy.
C3 University of L'Aquila; University of Florence; Azienda Ospedaliero
   Universitaria Careggi; University of Florence; Azienda Ospedaliero
   Universitaria Careggi; University of L'Aquila
RP Angeletti, C (corresponding author), Civil Hosp G Mazzini Teramo, Piazza Italia 1, I-64100 Teramo, Italy.
EM chiara.angeletti@gmail.com
RI Angeletti, Chiara/HJB-3435-2022; Ciccozzi, Alessana/AAC-3271-2022;
   Angeletti, Paolo/KYP-0706-2024; Marinangeli, Franco/IQR-6149-2023
OI Angeletti, Chiara/0000-0002-3656-1040; Ciccozzi,
   Alessana/0000-0003-0250-7991; Paesani, Martina/0000-0002-7517-0384;
   Marinangeli, Franco/0000-0002-4931-7717; Gyra,
   Aglaia/0000-0003-1866-8677
CR Adams LM, 2015, CURR RHEUMATOL REV, V11, P96, DOI 10.2174/1573397111666150619095330
   Allegri M, 2016, CURR MED RES OPIN, V32, P377, DOI 10.1185/03007995.2015.1129321
   American Society for Pain Management Nursing & American Nurses Association, 2016, PAIN MAN NURS SCOP S
   Angeletti C, 2018, PAIN RES MANAG, V2018, DOI 10.1155/2018/5165262
   [Anonymous], 1996, Cancer pain relief
   [Anonymous], 2015, COD ETH NURS
   [Anonymous], 2013, Diagnostic and statistical manual of mental disorders
   Ashburn MA, 2012, ANESTHESIOLOGY, V116, P248, DOI 10.1097/ALN.0b013e31823c1030
   Brennan F, 2007, ANESTH ANALG, V105, P205, DOI 10.1213/01.ane.0000268145.52345.55
   Correa-de-Araujo R, 2016, HEALTH CARE WOMEN IN, V37, P2, DOI 10.1080/07399332.2015.1102269
   Demyttenaere K, 2007, PAIN, V129, P332, DOI 10.1016/j.pain.2007.01.022
   Derry S, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008609.pub2
   Doorenbos AZ, 2013, J PAIN, V14, P1533, DOI 10.1016/j.jpain.2013.07.006
   Dowell D, 2016, AM FAM PHYSICIAN, V93, P970
   Ferrell Betty, 2005, Pain Manag Nurs, V6, P83, DOI 10.1016/j.pmn.2005.06.001
   Flaskerud JH, 2015, ISSUES MENT HEALTH N, V36, P74, DOI 10.3109/01612840.2014.932873
   Garcia-Larrea L, 2013, PAIN, V154, pS29, DOI 10.1016/j.pain.2013.09.001
   Heikkinen J, 2019, MATURITAS, V127, P18, DOI 10.1016/j.maturitas.2019.05.011
   Henschke N, 2015, MAYO CLIN PROC, V90, P139, DOI 10.1016/j.mayocp.2014.09.010
   Hooten WM, 2016, MAYO CLIN PROC, V91, P955, DOI 10.1016/j.mayocp.2016.04.029
   Hoy D, 2014, ANN RHEUM DIS, V73, P1309, DOI 10.1136/annrheumdis-2013-204431
   Jomar RT, 2014, ECANCERMEDICALSCIENC, V8, DOI 10.3332/ecancer.2014.462
   Kudlow PA, 2015, J AFFECT DISORDERS, V188, P134, DOI 10.1016/j.jad.2015.08.030
   Limón D, 2015, EUR J PHARM BIOPHARM, V96, P421, DOI 10.1016/j.ejpb.2015.09.007
   Mansfield KE, 2016, PAIN, V157, P55, DOI 10.1097/j.pain.0000000000000314
   Mathews L, 2011, INDIAN J PALLIAT CAR, V17, P70, DOI 10.4103/0973-1075.76247
   Meghani SH, 2012, PAIN MED, V13, P5, DOI 10.1111/j.1526-4637.2011.01289.x
   Mercadante S, 2015, EXPERT REV NEUROTHER, V15, P1249, DOI 10.1586/14737175.2015.1101347
   Miceli L, 2017, MINERVA ANESTESIOL, V83, P33, DOI 10.23736/S0375-9393.16.11099-5
   Naranjo C, 2019, EXPERT REV NEUROTHER, V19, P1201, DOI 10.1080/14737175.2019.1653760
   Nguyen TA, 2013, J DRUGS DERMATOL, V12, P1131
   Pasero C, 2016, PAIN MANAG NURS, V17, P170, DOI [10.1016/j.pmn.2016.03.001, 10.1016/j.pmn.2016.08.002]
   Peptu C, 2015, CURR PHARM DESIGN, V21, P6125, DOI 10.2174/1381612821666151027152752
   Reme SE, 2011, EUR J PAIN, V15, P1075, DOI 10.1016/j.ejpain.2011.04.012
   Steel Z, 2014, INT J EPIDEMIOL, V43, P476, DOI 10.1093/ije/dyu038
   Van Oudenhove L, 2016, GASTROENTEROLOGY, V150, P866, DOI 10.1053/j.gastro.2015.11.010
   Von Korff M, 2005, PAIN, V113, P331, DOI 10.1016/j.pain.2004.11.010
   West SJ, 2015, NEUROSCIENCE, V300, P254, DOI 10.1016/j.neuroscience.2015.05.020
NR 38
TC 2
Z9 2
U1 0
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2021
VL 14
BP 107
EP 115
DI 10.2147/JPR.S245792
PG 9
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA QA8WO
UT WOS:000613723600001
PM 33531830
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Liu, XM
   Qi, YX
   Zheng, JY
   Hao, SQ
   Hao, WW
   Du, Y
   Li, WJ
   An, LX
AF Liu, Xu-ming
   Qi, Yu-xuan
   Zheng, Jian-yong
   Hao, Si-qi
   Hao, Wen-wen
   Du, Yi
   Li, Wen-jing
   An, Li-xin
TI Transcutaneous Electrical Acupoint Stimulation Reduces Postoperative
   Abdominal Pain after Endoscopic Submucosal Dissection: A Single-Center,
   Prospective, and Randomized Controlled Trial
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article; Early Access
DE transcutaneous electrical acupoint stimulation; endoscopic submucosal
   dissection; postoperative abdominal pain; randomized controlled trial
ID RELIEF
AB Objective: To evaluate the efficacy of perioperative transcutaneous electrical acupoint stimulation (TEAS) for reducing postoperative abdominal pain in patients after endoscopic submucosal dissection (ESD) for early gastric and esophageal neoplasms. Methods: A total of 129 patients undergoing ESD were assigned randomly to the TEAS group (64 cases) or the sham group (65 cases) using computer-generated random numbers and stratified by the surgical type (i.e., gastric or esophageal ESD). Patients in the TEAS group were treated bilaterally at the acupoints Hegu (LI 4), Neiguan (PC 6), Zusanli (ST 36), and Shangjuxu (ST 37), with the stimulation current frequency 2/100 Hz and intensity to the patient's maximum tolerance level. Patients in the sham group were treated at sham acupoints, and no electrical stimulation was given from the HANS stimulator. The TEAS and sham stimulations are both given from 30 min before ESD to the end of surgery. The primary outcome was the incidence of moderate-to-severe pain within 24 h. Secondary outcomes included the area under the curve (AUC) of Numeric Rating Scale (NRS) pain score from 1 to 48 h, morphine consumption after ESD, intraoperative hemodynamic parameters and postoperative nausea and vomiting (PONV).Results: The incidence of moderate-to-severe pain within 24 h postoperative period was significantly decreased by TEAS [22 (37.9%) vs. 40 (64.5%), P=0.004]. Patients needing morphine were also reduced by TEAS treatment [19 (32.7%) vs. 40 (64.5%), P<0.01]. TEAS significantly decreased the proportion and incidence of PONV compared with the sham group (P=0.06). Intraoperative hemodynamic parameters, recovery of gastrointestinal function, postoperative adverse events were similar between the two groups. According to the results of multivariate logistic regression, TEAS treatment was a protective factor associated with reduced incidence of NRS scores >= 4 (OR=0.227; 95% CI: 0.100 to 0.512; P<0.01), whereas patients undergoing gastric ESD had a much lower incidence of NRS scores >= 4 than esophageal ESD (OR=0.287; 95% CI: 0.133 to 0.621; P=0.002).Conclusions: TEAS can effectively reduce the incidence of moderate-to-severe pain in patients after ESD. TEAS demonstrates an morphine-sparing effect and reduces the occurrence of PONV.
C1 [Liu, Xu-ming; Qi, Yu-xuan; Hao, Si-qi; Hao, Wen-wen; Li, Wen-jing; An, Li-xin] Capital Med Univ, Beijing Friendship Hosp, Dept Anesthesiol, Beijing 100050, Peoples R China.
   [Zheng, Jian-yong] Peking Univ Canc Hosp, Dept Anesthesiol, Beijing 100053, Peoples R China.
   [Du, Yi] Capital Med Univ, Beijing Friendship Hosp, Dept Tradit Chinese Med, Beijing 100050, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP An, LX (corresponding author), Capital Med Univ, Beijing Friendship Hosp, Dept Anesthesiol, Beijing 100050, Peoples R China.
EM anlixin8120@163.com
RI Qi, Yuxuan/AAH-4783-2021
FU Beijing Municipal Administration of Traditional Chinese Medicine
   [BJZYQN-2023-22]; Beijing Tongzhou District Science and Technology
   Program, China [WS2024036]
FX Supported by Beijing Municipal Administration of Traditional Chinese
   Medicine (No. BJZYQN-2023-22), and Beijing Tongzhou District Science and
   Technology Program, China (No. WS2024036)
CR Chang XL, 2023, BMC COMPLEMENT MED, V23, DOI 10.1186/s12906-023-04075-9
   Hayashi T, 2017, GASTROINTEST ENDOSC, V86, P358, DOI 10.1016/j.gie.2016.11.032
   Hou LL, 2016, J TRADIT CHIN MED, V36, P450
   Jung DH, 2015, ENDOSCOPY, V47, P1119, DOI 10.1055/s-0034-1392537
   Kim B, 2015, SURG ENDOSC, V29, P714, DOI 10.1007/s00464-014-3730-4
   Kim HI, 2024, J CLIN MED, V13, DOI 10.3390/jcm13113119
   Kim JE, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003593
   Kim JW, 2019, SURG ENDOSC, V33, P794, DOI 10.1007/s00464-018-6345-3
   Kim SY, 2016, DIGEST DIS SCI, V61, P3560, DOI 10.1007/s10620-016-4325-9
   Li D, 2019, CLIN COLON RECT SURG, V32, P138, DOI 10.1055/s-0038-1676480
   Li WJ, 2021, J INTEGR MED-JIM, V19, P211, DOI 10.1016/j.joim.2021.01.005
   Li YJ, 2023, ANAESTH CRIT CARE PA, V42, DOI 10.1016/j.accpm.2023.101273
   Liu Q, 2020, INT J SURG, V73, P28, DOI 10.1016/j.ijsu.2019.11.027
   Liu SB, 2021, NATURE, V598, P641, DOI 10.1038/s41586-021-04001-4
   Luo X, 2023, J CLIN MED, V12, DOI 10.3390/jcm12051816
   Maple JT, 2015, GASTROINTEST ENDOSC, V81, P1311, DOI 10.1016/j.gie.2014.12.010
   Misumi Y, 2021, J CLIN MED, V10, DOI 10.3390/jcm10112511
   Pyo JH, 2016, GUT LIVER, V10, P549, DOI 10.5009/gnl15302
   Shah S, 2022, CURR PAIN HEADACHE R, V26, P453, DOI 10.1007/s11916-022-01048-4
   Tanabe S, 2017, GASTRIC CANCER, V20, pS45, DOI 10.1007/s10120-016-0664-7
   Uozumi T, 2023, CLIN ENDOSC, V56, P409, DOI 10.5946/ce.2023.024
   Wang D, 2022, PAIN RES MANAG, V2022, DOI 10.1155/2022/7570533
   Wang Y, 2023, JAMA SURG, V158, P20, DOI 10.1001/jamasurg.2022.5674
   Yu CH, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12081660
NR 24
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD 2025 DEC 15
PY 2025
DI 10.1007/s11655-025-3844-7
EA DEC 2025
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA W5324
UT WOS:001639697600001
PM 41396394
DA 2026-01-16
ER

PT J
AU Wang, ZZ
   Zheng, XH
   Lin, J
   Zhou, B
   Zeng, ZM
   Gao, HW
   Chen, HX
   Tang, CZ
AF Wang, Zhenzhen
   Zheng, Xiahai
   Lin, Jing
   Zhou, Bin
   Zeng, Zhenming
   Gao, Haiwei
   Chen, Haoxiong
   Tang, Chunzhi
TI Electroacupuncture ameliorates cartilage damage in a rat model of knee
   osteoarthritis and regulates expression of miRNAs and the TLR4/NF-κB
   pathway
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE cartilage damage; inflammation; knee osteoarthritis; microRNA; TLR4;
   NF-kappa B
ID PAIN
AB Background: Electroacupuncture (EA) has been shown to be effective in the treatment of knee osteoarthritis (KOA); however, its underlying mechanism remains unclear.Methods: 40 KOA model rats were divided into control, untreated model, EA-treated model and celecoxib-treated model groups (n=10 each). Articular cartilage of the knee joint was stained with hematoxylin and eosin (HE), periodic acid-Schiff (PAS) and Alcian blue (AB)-PAS, and Moran/Mankin scores were used to evaluate articular cartilage injury across groups. Moreover, toll-like receptor (TLR)4/nuclear factor (NF)-kappa B pathway (TN-P)-related protein levels in the articular cartilage were detected using Western blotting. Oxidative stress and inflammatory biomarkers in the synovial fluid were measured by enzyme-linked immunosorbent assay (ELISA). MicroRNA (miRNA/miR) expression was measured by quantitative real-time polymerase chain reaction (qRT-PCR).Results: Compared with the control group, Moran scores increased and Mankin scores decreased in the KOA model rats. In addition, compared with those in the control group, levels of superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and interleukin (IL)-10 were significantly decreased, while levels of IL-1 beta, IL-6, tumor necrosis factor (TNF)-alpha, malondialdehyde (MDA) and nitric oxide (NO) were significantly increased, in the synovial fluid of the KOA model group. Protein levels of TLR4, anti-myeloid differentiation primary response protein 88 (MyD88) and p65 NF-kappa B phosphorylation were significantly increased in the articular cartilage of the KOA model group. EA and celecoxib treatment reversed the trends of these protein levels. Moreover, expression of miR-15a/127/140/146a/216a-5p and miR-27a-3p in the articular cartilage were markedly increased in KOA rats, while EA and celecoxib treatment reduced their expression.Conclusions: EA reduces inflammation, oxidative stress and cartilage damage in KOA model rats, likely through regulation of the miRNA/TLR4/NF-kappa B pathway.
C1 [Wang, Zhenzhen; Zheng, Xiahai; Lin, Jing; Zhou, Bin; Zeng, Zhenming; Gao, Haiwei; Chen, Haoxiong] Guangzhou Univ Chinese Med, Dept Rehabil, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Wang, Zhenzhen; Tang, Chunzhi] Guangzhou Univ Chinese Med, Med Coll Acupuncture Moxibust & Rehabil, 12 Jichang Rd, Guangzhou 510000, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Tang, CZ (corresponding author), Guangzhou Univ Chinese Med, Med Coll Acupuncture Moxibust & Rehabil, 12 Jichang Rd, Guangzhou 510000, Peoples R China.
EM jordan664@163.com
OI Wang, Zhenzhen/0009-0007-8302-0523
FU Project of Administration of Traditional Chinese Medicine of Guangdong
   Province of China [20202086]
FX The authors disclosed receipt of the following financial support for the
   research, authorship and/or publication of this article: This work was
   supported by the Project of Administration of Traditional Chinese
   Medicine of Guangdong Province of China (grant no. 20202086).
CR Bisson DG, 2020, J CELL MOL MED, V24, P11355, DOI 10.1111/jcmm.15733
   Bu Y, 2022, CHIN J INTEGR MED, V28, P153, DOI 10.1007/s11655-021-3350-5
   Cao PH, 2020, EXPERT OPIN PHARMACO, V21, P797, DOI 10.1080/14656566.2020.1732924
   Chen N, 2017, AM J CHINESE MED, V45, P965, DOI 10.1142/S0192415X17500513
   Chou WC, 2022, ENVIRON TOXICOL, V37, P478, DOI 10.1002/tox.23414
   Geurts J, 2011, RHEUMATOLOGY, V50, P1216, DOI 10.1093/rheumatology/ker021
   Gregori D, 2018, JAMA-J AM MED ASSOC, V320, P2564, DOI 10.1001/jama.2018.19319
   Guo CG, 2020, GUT LIVER, V14, P179, DOI 10.5009/gnl19201
   Huang HT, 2021, PAIN MED, V22, P352, DOI 10.1093/pm/pnaa230
   Huang Z, 2023, IMMUNOPHARM IMMUNOT, V45, P61, DOI 10.1080/08923973.2022.2115924
   Jokar Z, 2024, SAGE OPEN NURS, V10, DOI 10.1177/23779608241260822
   Kapoor M, 2011, NAT REV RHEUMATOL, V7, P33, DOI 10.1038/nrrheum.2010.196
   Li ZY, 2020, J MUSCULOSKEL NEURON, V20, P398
   Lv ZT, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1899-6
   MORAN ME, 1992, J BONE JOINT SURG BR, V74, P659, DOI 10.1302/0301-620X.74B5.1527109
   Nasi S, 2014, JOINT BONE SPINE, V81, P320, DOI 10.1016/j.jbspin.2014.01.018
   Papathanasiou I, 2020, BIOCHEM BIOPH RES CO, V522, P783, DOI 10.1016/j.bbrc.2019.11.168
   Sahbaz T, 2024, REUMATISMO, V76, P121, DOI 10.4081/reumatismo.2024.1660
   Shi XW, 2020, BIOMED PHARMACOTHER, V123, DOI 10.1016/j.biopha.2019.109724
   Sun SY, 2023, EVID-BASED COMPL ALT, V2023, DOI [10.1155/2023/9050763, 10.1155/2023/9050763, DOI 10.1155/2023/9050763]
   Sun XS, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16234701
   Wan HS, 2022, J INT MED RES, V50, DOI 10.1177/03000605221104764
   Wang KW, 2023, J ORTHOP SURG RES, V18, DOI 10.1186/s13018-023-04201-w
   Wang Y, 2019, ARTIF CELL NANOMED B, V47, P1241, DOI 10.1080/21691401.2019.1596940
   Wu GW, 2019, CHIN J INTEGR MED, V25, P677, DOI 10.1007/s11655-018-2916-8
   Xu XT, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.951860
   Yu Yi-Nan, 2022, Zhen Ci Yan Jiu, V47, P471, DOI 10.13702/j.1000-0607.20211269
   Zeng XJ, 2022, J ENVIRON PUBLIC HEA, V2022, DOI 10.1155/2022/1933504
   Zhang GC, 2020, LIFE SCI, V261, DOI 10.1016/j.lfs.2020.118429
   Zhang Xiao-Qin, 2023, Zhen Ci Yan Jiu, V48, P185, DOI 10.13702/j.1000-0607.20220246
   Zhang YC, 2022, AUTOIMMUNITY, V55, P577, DOI 10.1080/08916934.2022.2103798
   Zhao YX, 2020, J PAIN RES, V13, P239, DOI 10.2147/JPR.S241101
NR 32
TC 1
Z9 1
U1 2
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD JUN
PY 2025
VL 43
IS 3
BP 164
EP 173
DI 10.1177/09645284251342259
EA MAY 2025
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 3LT9J
UT WOS:001491070800001
PM 40390302
DA 2026-01-16
ER

PT J
AU Jung, M
   Rein, N
   Fuchs, B
AF Jung, M.
   Rein, N.
   Fuchs, B.
TI Physical Therapy for Chemotherapy-induced Peripheral Neuropathy in
   Pediatric Oncology
SO KLINISCHE PADIATRIE
LA German
DT Article
DE chemotherapy-induced peripheral neuropathy; pediatric oncology; physical
   therapy; neurologic rehabilitation; systematic review;
   vinchristin-induced polyneuropathy
ID CANCER; CHILDREN; POLYNEUROPATHY; ACUPUNCTURE; VINCRISTINE; PERFORMANCE;
   MANAGEMENT; CIPN; LIFE
AB Background: Chemotherapy-induced peripheral neuropathy is a frequent side-effect of drugs that are used in the treatment of cancer. Affected individuals can suffer from motor, sensory or autonomy nerve damage. Further medication is used for the treatment of CIPN which can cause further side-effects. Patients should be offered physical therapy treatment to relieve the symptoms.
   Objective: The aim of this article is to give an overview of available literature investigating physical therapy in CIPN in pediatric oncology.
   Methods: To determine relevant literature, a systematic review was conducted in the databases CINAHL, The Cochrane Library, ERIC, MEDPILOT, PEDro, PsycARTICLES, PsycINFO, PubMed and DIMDI. Besides the methodological quality of the identified literature is supposed to be reviewed.
   Results: There is no current literature regarding the subject of this article, so no evaluation of the quality could be carried out. Although several publications concerning adults could be identified and transfer could be established for pediatrics.
   Conclusion: Acupuncture appeared to be effective in the treatment of CIPN in adults. Good results appeared especially regarding pain. Sensorimotor training, balance training, electrotherapy and alternative methods like Reiki and Yoga showed good results for patients symptoms. These treatment methods give a future prospect how CIPN in children can be treated successfully - but further pediatric research is necessary.
C1 [Jung, M.; Fuchs, B.] Hsch Fresenius gGmbH, Sch Therapy & Social Work, Marienburgstr 2, D-65510 Idstein, Germany.
   [Rein, N.] Hsch Fresenius gGmbH, Sch Med, Idstein, Germany.
RP Jung, M (corresponding author), Hsch Fresenius gGmbH, Sch Therapy & Social Work, Marienburgstr 2, D-65510 Idstein, Germany.
EM jung.michael@hs-fresenius.de
CR [Anonymous], NEUROLOGIE
   Cavaletti G, 2002, EUR J CANCER, V38, P1832, DOI 10.1016/S0959-8049(02)00229-0
   Cil T, 2009, J PEDIAT HEMATOL ONC, V31, P787, DOI 10.1097/MPH.0b013e3181b530ad
   Clark PG, 2012, J EVID-BASED INTEGR, V17, P161, DOI 10.1177/2156587212450175
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Gilchrist L, 2012, SEMIN PEDIATR NEUROL, V19, P9, DOI 10.1016/j.spen.2012.02.011
   Gilchrist LS, 2013, SUPPORT CARE CANCER, V21, P847, DOI 10.1007/s00520-012-1591-8
   Hartman A, 2006, CANCER, V106, P1395, DOI 10.1002/cncr.21706
   Jensen W, 2014, CONTEMP CLIN TRIALS, V37, P120, DOI 10.1016/j.cct.2013.11.013
   Jongen JLM, 2015, J NEURO-ONCOL, V121, P229, DOI 10.1007/s11060-014-1632-x
   Jung M, 2016, KLIN PADIATR, V228, P157, DOI 10.1055/s-0042-105291
   Kannarkat G, 2007, CURR OPIN NEUROL, V20, P719
   Kim JH, 2015, GYNECOL ONCOL, V136, P453, DOI 10.1016/j.ygyno.2015.01.524
   Liedberg GM, 2009, DISABIL REHABIL, V31, P1402, DOI 10.1080/09638280802621382
   Mattle H, 2011, KURZLEHRBUCH NEUROLO
   Numismatische Zeitschrift, 2001, S ELBSTV OST NUM GES
   Pignataro RM, 2010, REHABIL ONCOL, V28, P10, DOI 10.1097/01893697-201028020-00002
   Postma TJ, 2000, ANN ONCOL, V11, P509, DOI 10.1023/A:1008345613594
   Purser MJ, 2014, CAN J NEUROL SCI, V41, P442, DOI 10.1017/S0317167100018461
   Schloss JM, 2013, CLIN NUTR, V32, P888, DOI 10.1016/j.clnu.2013.04.007
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Smith TJ, 2010, J PAIN SYMPTOM MANAG, V40, P883, DOI 10.1016/j.jpainsymman.2010.03.022
   Steimann M, 2011, ONKOLOGE, V17, P940, DOI 10.1007/s00761-011-2111-z
   Steimann M., 2014, GMS ONKOL REHABIL SO, V3
   Streckmann F, 2014, BEWEGUNGSTHERAPIE GE, V30, P179, DOI 10.1055/s-0034-1384422
   Tofthagen C, 2014, REHABIL ONCOL, V32, P38, DOI 10.1097/01893697-201432040-00007
   Visovsky Constance, 2007, Clin J Oncol Nurs, V11, P901
   Wong Raimond, 2006, Acupunct Med, V24, P87
NR 30
TC 7
Z9 9
U1 1
U2 20
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0300-8630
EI 1439-3824
J9 KLIN PADIATR
JI Klinische Padiatr.
PD NOV
PY 2016
VL 228
IS 6-7
BP 313
EP 318
DI 10.1055/s-0042-111692
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA ED1XG
UT WOS:000388637600005
PM 27846661
DA 2026-01-16
ER

PT J
AU Jung, M
   Rein, N
   Fuchs, B
AF Jung, M.
   Rein, N.
   Fuchs, B.
TI Physical Therapy for Chemotherapy-induced Peripheral Neuropathy in
   Pediatric Oncology
SO PHYSIKALISCHE MEDIZIN REHABILITATIONSMEDIZIN KURORTMEDIZIN
LA German
DT Article
DE chemotherapy-induced peripheral neuropathy; pediatric oncology; physical
   therapy; neurologic rehabilitation; systematic review;
   vinchristin-induced polyneuropathy
ID CANCER; CHILDREN; POLYNEUROPATHY; ACUPUNCTURE; VINCRISTINE; PERFORMANCE;
   MANAGEMENT; CIPN; LIFE
AB Background Chemotherapy-induced peripheral neuropathy is a frequent side-effect of drugs that are used in the treatment of cancer. People affected can suffer from motor, sensory or autonomy nerve damage. Further medication is used for the treatment of CIPN which can cause further side-effects. Patients should be offered physical therapy treatment to relieve the symptoms.
   Objective The aim of this article is to give an overview of available literature affecting physical therapy in CIPN in pediatric oncology.
   Methods To determine relevant literature, a systematic review was conducted in the databases CINAHL, The Cochrane Library, ERIC, MEDPILOT, PEDro, PsycARTICLES, PsycINFO, PubMed and DIMDI. Besides the methodological quality of the identified literature is supposed to be reviewed.
   Results There is no current literature regarding the subject of this article, so no evaluation of the quality could be carried out. Although several publications concerning adults could be identified and transfer could be established for pediatrics.
   Conclusion Acupuncture appeared to be effective in the treatment of CIPN in adults. Good results appeared especially regarding pain. Sensorimotor training, balance training, electrotherapy and alternative methods like Reiki and Yoga showed good results for patients symptoms. These treatment methods give a future prospect how CIPN in children can be treated successfully - but further pediatric research is necessary.
C1 [Jung, M.; Fuchs, B.] Hsch Fresenius gGmbH, Sch Therapy & Social Works, Marienburgstr 2, D-65510 Idstein, Germany.
   [Rein, N.] Hsch Fresenius gGmbH, Sch Med, Idstein, Germany.
RP Jung, M (corresponding author), Hsch Fresenius gGmbH, Sch Therapy & Social Works, Marienburgstr 2, D-65510 Idstein, Germany.
EM jung.michael@hs-fresenius.de
CR [Anonymous], NEUROLOGIE
   Cavaletti G, 2002, EUR J CANCER, V38, P1832, DOI 10.1016/S0959-8049(02)00229-0
   Cil T, 2009, J PEDIAT HEMATOL ONC, V31, P787, DOI 10.1097/MPH.0b013e3181b530ad
   Clark PG, 2012, J EVID-BASED INTEGR, V17, P161, DOI 10.1177/2156587212450175
   Donald GK, 2011, ACUPUNCT MED, V29, P230, DOI 10.1136/acupmed.2011.010025
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Gilchrist L, 2012, SEMIN PEDIATR NEUROL, V19, P9, DOI 10.1016/j.spen.2012.02.011
   Gilchrist LS, 2013, SUPPORT CARE CANCER, V21, P847, DOI 10.1007/s00520-012-1591-8
   Hartman A, 2006, CANCER, V106, P1395, DOI 10.1002/cncr.21706
   Jensen W, 2014, CONTEMP CLIN TRIALS, V37, P120, DOI 10.1016/j.cct.2013.11.013
   Jongen JLM, 2015, J NEURO-ONCOL, V121, P229, DOI 10.1007/s11060-014-1632-x
   Jung M, 2016, KLIN PADIATR, V228, P157, DOI 10.1055/s-0042-105291
   Kannarkat G, 2007, CURR OPIN NEUROL, V20, P719
   Kim JH, 2015, GYNECOL ONCOL, V136, P453, DOI 10.1016/j.ygyno.2015.01.524
   Liedberg GM, 2009, DISABIL REHABIL, V31, P1402, DOI 10.1080/09638280802621382
   Mattle H, 2011, KURZLEHRBUCH NEUROLO
   Numismatische Zeitschrift, 2001, S ELBSTV OST NUM GES
   Pignataro RM, 2010, REHABIL ONCOL, V28, P10, DOI 10.1097/01893697-201028020-00002
   Postma TJ, 2000, ANN ONCOL, V11, P509, DOI 10.1023/A:1008345613594
   Purser MJ, 2014, CAN J NEUROL SCI, V41, P442, DOI 10.1017/S0317167100018461
   Schloss JM, 2013, CLIN NUTR, V32, P888, DOI 10.1016/j.clnu.2013.04.007
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Smith TJ, 2010, J PAIN SYMPTOM MANAG, V40, P883, DOI 10.1016/j.jpainsymman.2010.03.022
   Steimann M, 2011, ONKOLOGE, V17, P940, DOI 10.1007/s00761-011-2111-z
   Steimann M., 2014, GMS ONKOL REHABIL SO, V3
   Streckmann F, 2014, BEWEGUNGSTHERAPIE GE, V30, P179, DOI 10.1055/s-0034-1384422
   Tofthagen C, 2014, REHABIL ONCOL, V32, P38, DOI 10.1097/01893697-201432040-00007
   Visovsky Constance, 2007, Clin J Oncol Nurs, V11, P901
   Wong Raimond, 2006, Acupunct Med, V24, P87
NR 30
TC 2
Z9 4
U1 1
U2 18
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0940-6689
EI 1439-085X
J9 PHYS MED REHAB KUROR
JI Physik. Med. Rehabilitationsmed. Kurort.
PD JAN
PY 2018
VL 28
IS 1
BP 46
EP 52
DI 10.1055/s-0043-124644
PG 7
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation; Sport Sciences
GA FW2ZA
UT WOS:000425173100006
DA 2026-01-16
ER

PT J
AU Guo, F
   Han, RL
   Sun, L
   Zheng, LL
   Wang, YZ
   Yan, YT
   Liu, C
   Qin, Y
   Yuan, C
   Wang, S
   Sun, XD
   Gao, CJ
AF Guo, Fei
   Han, Ruili
   Sun, Li
   Zheng, Lanlan
   Wang, Yanzheng
   Yan, Yuting
   Liu, Chen
   Qin, Yuan
   Yuan, Chen
   Wang, Shuang
   Sun, Xude
   Gao, Changjun
TI Effect of transcutaneous electrical acupoint stimulation on
   postoperative cognitive function in older patients with lung cancer: A
   randomized, double-blind, placebo-controlled trial
SO HELIYON
LA English
DT Article
DE Transcutaneous electrical acupoint stimulation; (TEAS); Postoperative
   cognitive dysfunction(POCD); Quality of life; Lung cancer; Older
   patients
ID DYSFUNCTION; ANESTHESIA; DELIRIUM; DECLINE; SURGERY; PREVENTION;
   FATIGUE; STRESS; SLEEP; PAIN
AB Objective: This trial was to examine the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative cognitive function in older patients who underwent thoracoscopic pulmonary resection.Methods: This was a prospective, randomized, double-blind, placebo-controlled study. 128 patients scheduled for surgery were randomly assigned to the TEAS group and sham-TEAS group. A standardized intervention of TEAS or sham-TEAS on the acupoints of Baihui (DU20) and bilateral Neiguan (PC6), Hegu (LI4), and Zusanli (ST36) from 30 min before anesthesia induction until the end of the surgery, combined with a general anesthetic protocol performed in the two groups respectively. The primary outcome was the incidence of postoperative cognitive dysfunction (POCD) assessed via the Montreal Cognitive Assessment (MoCA) scale at each time point. The secondary outcomes included the results of the Mini-Mental State Examination (MMSE) score, the Numerical Rating Scale (NRS) on pain and sleep, the European Organization for Research and Treatment of Cancer Quality of Life (EORTC-QLQ-C30), and a chronic pain questionnaire at relative time points.Results: Participants who completed the 12-month trial of the two groups were well-matched in baseline demographic and clinical parameters. At postoperative day 1, day 7, and day 30 time points, the incidence of POCD in the sham-TEAS group was always significantly higher than in the TEAS group (65.4% vs 20%, 43.6% vs 7.3%, 40% vs 3.6%, all P < 0.001). Also, the TEAS group showed better scores of MMSE, sleep, and pain compared with the sham-TEAS group (all P < 0.001). At 6 and 12 months points, the global health scores of the TEAS group were still significantly higher than the sham-TEAS group, and the prevalence of chronic pain was significantly lower than the sham-TEAS group (all P < 0.05).Conclusion: TEAS could effectively improve the postoperative cognitive function and long-term life quality of geriatric patients with lung cancer.
C1 [Guo, Fei; Han, Ruili; Sun, Li; Zheng, Lanlan; Wang, Yanzheng; Liu, Chen; Qin, Yuan; Yuan, Chen; Wang, Shuang; Sun, Xude; Gao, Changjun] Air Force Med Univ, Dept Anesthesiol, Affiliated Hosp 2, Xian, Peoples R China.
   [Sun, Xude; Gao, Changjun] Air Force Med Univ, Dept Anesthesiol, Affiliated Hosp 2, Xian 710038, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Sun, XD; Gao, CJ (corresponding author), Air Force Med Univ, Dept Anesthesiol, Affiliated Hosp 2, Xian 710038, Peoples R China.
EM sunxude@fmmu.edu.cn; gaocj74@163.com
RI Guo, Fei/JJE-8063-2023; yuan, chen/JRW-7055-2023
FU National Natural Science Foundation of China [81971225]; Clinical
   Research Project of the Air Force Medical University [2021LC2207]
FX This research was supported by the National Natural Science Foundation
   of China (No. Grant number 81971225) and the Clinical Research Project
   of the Air Force Medical University (No. 2021LC2207) .
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   Avidan MS, 2017, LANCET, V390, P267, DOI 10.1016/S0140-6736(17)31467-8
   Batchelor TJP, 2019, EUR J CARDIO-THORAC, V55, P91, DOI 10.1093/ejcts/ezy301
   BRAEKHUS A, 1992, J AM GERIATR SOC, V40, P1139, DOI 10.1111/j.1532-5415.1992.tb01804.x
   Chen JB, 2020, INT J SURG, V73, P57, DOI 10.1016/j.ijsu.2019.10.036
   Chen YQ, 2015, INT J CLIN EXP MED, V8, P5781
   Chi YL, 2019, AM J CHINESE MED, V47, P1445, DOI 10.1142/S0192415X19500745
   Deiner S, 2021, ANN SURG, V274, pE1108, DOI 10.1097/SLA.0000000000003764
   Ding X, 2021, J MOL NEUROSCI, V71, P515, DOI 10.1007/s12031-020-01673-x
   Evered L, 2018, BRIT J ANAESTH, V121, P1005, DOI 10.1016/j.bja.2017.11.087
   Ezhevskaya AA, 2019, J NEUROSURG-SPINE, V31, P894, DOI 10.3171/2019.4.SPINE184
   Fan YX, 2017, J CLIN ANESTH, V39, P77, DOI 10.1016/j.jclinane.2017.03.023
   Feng B, 2019, PSYCHIAT CLIN NEUROS, V73, P179, DOI 10.1111/pcn.12810
   Gao F, 2018, CLIN INTERV AGING, V13, P2127, DOI 10.2147/CIA.S183698
   Hoffman AJ, 2007, ONCOL NURS FORUM, V34, P785, DOI 10.1188/07.ONF.785-792
   Hou LL, 2017, J THORAC DIS, V9, P1959, DOI 10.21037/jtd.2017.06.05
   Kotekar N, 2018, CLIN INTERV AGING, V13, P2267, DOI 10.2147/CIA.S133896
   Li H, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-053309
   Liu BY, 2022, CNS NEUROSCI THER, V28, P470, DOI 10.1111/cns.13763
   Liu SB, 2021, NATURE, V598, P641, DOI 10.1038/s41586-021-04001-4
   Lu ZH, 2021, J CLIN ANESTH, V74, DOI 10.1016/j.jclinane.2021.110453
   Moller JT, 1998, LANCET, V351, P857, DOI 10.1016/S0140-6736(97)07382-0
   Monk TG, 2008, ANESTHESIOLOGY, V108, P18, DOI 10.1097/01.anes.0000296071.19434.1e
   Nasreddine ZS, 2005, J AM GERIATR SOC, V53, P695, DOI 10.1111/j.1532-5415.2005.53221.x
   O'Gara BP, 2021, ANESTHESIOLOGY, V135, P1132, DOI 10.1097/ALN.0000000000004046
   Patel D, 2016, ANAESTHESIA, V71, P1144, DOI 10.1111/anae.13571
   Radtke FM, 2013, BRIT J ANAESTH, V110, P98, DOI 10.1093/bja/aet055
   Ritmala-Castren M, 2014, SCAND J CARING SCI, V28, P435, DOI 10.1111/scs.12072
   Rodriguez C S, 2001, Pain Manag Nurs, V2, P38, DOI 10.1053/jpmn.2001.23746
   Rundshagen I, 2014, DTSCH ARZTEBL INT, V111, DOI 10.3238/arztebl.2014.0119
   Schabath MB, 2019, CANCER EPIDEM BIOMAR, V28, P1563, DOI 10.1158/1055-9965.EPI-19-0221
   Shen Y, 2022, GERONTOLOGY, V68, P538, DOI 10.1159/000517511
   Sikkes SAM, 2021, ALZHEIMERS DEMENT, V17, P255, DOI 10.1002/alz.12188
   Small C, 2020, BJS-BRIT J SURG, V107, pE70, DOI 10.1002/bjs.11477
   Steinmetz J, 2009, ANESTHESIOLOGY, V110, P548, DOI 10.1097/ALN.0b013e318195b569
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Tida JA, 2018, ACUPUNCT MED, V36, P386, DOI 10.1136/acupmed-2017-011515
   van der Stouwe ECD, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03579-3
   Wang H, 2014, BRIT J ANAESTH, V112, P1075, DOI 10.1093/bja/aeu001
   Weerink LBM, 2018, ANN SURG ONCOL, V25, P231, DOI 10.1245/s10434-017-6118-6
   Xie ZZ, 2017, NEUROL RES, V39, P559, DOI 10.1080/01616412.2017.1315864
   Yalcin EK, 2021, EXPERT OPIN EMERG DR, V26, P371, DOI 10.1080/14728214.2021.2009799
   Zhou J, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000933
NR 43
TC 6
Z9 8
U1 4
U2 14
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD SEP
PY 2023
VL 9
IS 9
AR e19386
DI 10.1016/j.heliyon.2023.e19386
EA AUG 2023
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA T6NR3
UT WOS:001079138500001
PM 37809441
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Hempen, CH
   Hummelsberger, J
AF Hempen, Carl-Hermann
   Hummelsberger, Josef
TI Traditional Chinese medicine (TCM)-what is myth and what is the state of
   evidence today?
SO BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ
LA German
DT Article
DE Chinese medicine; TCM; Acupuncture; Chinese herbal medicine; Evidence
ID CELL LUNG-CANCER; EFFICACY; QUALITY
AB Traditional Chinese medicine (TCM) is the most comprehensive and widely practiced system of medicine in the world. Originally, TCM appeared in our Western context as an unfathomable mythological doctrine. Once the linguistic barriers had been overcome, it became possible to understand and apply the terminological and physiological concepts, the method of diagnosis, and the clinical findings. Since the NIH consensus conference in 1998, our understanding of TCM has been the subject of methodologically robust studies. We now have evidence of the efficacy and effectiveness of acupuncture beyond its use in pain therapy and allergy treatment. Thanks to fMRI studies, among others, we also have a better understanding of the mechanisms underlying acupuncture. Meta-analyses and studies also confirm the efficacy of Chinese medicinal drugs and remedies in some fields, yet there is still extensive need for further research. But opportunities are also emerging for new medicines and prescriptions for (accompanying) treatments of infections, autoimmune diseases, cancer, metabolic illnesses, dermatological disorders, and gastrointestinal diseases. To enable further evaluation of TCM, but also to ensure an integrative, critical application in the practice of TCM, it is vital for doctors to have thorough training. Further institutionalisation is necessary to provide orientation and patient safety. The days of regarding TCM as some kind of mysticism are indeed long over and it can offer real opportunities for better patient care. In many fields, there is increasing evidence of TCM's effectiveness, yet further comprehensive research is essential. This should be encouraged unconditionally.
C1 [Hempen, Carl-Hermann] Tech Univ Munich, Georg Brauchle Ring 62, D-80992 Munich, Germany.
C3 Technical University of Munich
RP Hempen, CH (corresponding author), Tech Univ Munich, Georg Brauchle Ring 62, D-80992 Munich, Germany.
EM ch@hempen.de
FU Projekt DEAL
FX Open Access funding provided by Projekt DEAL.
CR Adams D, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006348.pub2
   ALTMAN DG, 1995, BRIT MED J, V311, P485, DOI 10.1136/bmj.311.7003.485
   [Anonymous], COCHRANE DATABASE SY, DOI DOI 10.1002/14651858.CD002291.PUB2
   AWMF, 2019, LEITL THER MIGR PROP
   AWMF, 2018, LEITL RUCK
   Barton DL, 2010, SUPPORT CARE CANCER, V18, P179, DOI 10.1007/s00520-009-0642-2
   Bensky D., 2005, Chinese Herbal Medicine: Materia Medica, Vthird
   Bensoussan A, 1998, JAMA-J AM MED ASSOC, V280, P1585, DOI 10.1001/jama.280.18.1585
   Cao H.Q., 2013, MOD MANUF ENG, V8, P12
   Chung V-CH, 2016, MEDICINE, V95, P7
   Deng HY, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012217.pub2
   Despeux C, 2000, GESCH CHINESISCHEN M
   Engelhardt Ute, 1997, Chinesische Diatetik.
   Flower A, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006568.pub2
   Flower A, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010446.pub2
   Freireich EJ., 1997, ADV J MIND BODY HLTH, V13, P41
   Fruhauf H, 2005, CHINESISCHE MED KR 1, P1
   Grant SJ, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006690.pub2
   Guo HR, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00454
   Guojia yaodian weiyuanhui, 2005, PHARM VR CHIN
   Hempen C-H, 2006, LEITFADEN CHINESISCH
   Hempen N, 2014, FORSCH KOMPLEMENTMED, V21, P401, DOI 10.1159/000369233
   Ho P.K., 1997, A brief history of Chinese medicine and its influence
   Hu C-J, 2019, PAOZHI AUFBEREITUNG
   Hummelsberger J, 2006, DTSCH ARZTEBL, V103, P21
   Jing Z, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006414.pub2
   Li XM, 2009, J ALLERGY CLIN IMMUN, V123, P297, DOI 10.1016/j.jaci.2008.12.026
   Liu JP, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003937.pub2
   Liu JP., 2002, COCHRANE DB SYST REV, DOI [DOI 10.1002/14651858.CD003642.PUB2, 10.1002/14651858.CD003642.pub2]
   Long XY, 2016, FRONT HUM NEUROSCI, V10, DOI 10.3389/fnhum.2016.00510
   Lu G.-D., 2002, CELESTIAL LANCETS HI
   MacDonald J., 2017, The acupuncture evidence project: a comparative literature review
   Manheimer E, 2009, J ALTERN COMPLEM MED, V15, P1001, DOI 10.1089/acm.2008.0414
   McCulloch M, 2006, J CLIN ONCOL, V24, P419, DOI 10.1200/JCO.2005.03.6392
   Needham J, 2004, SCI CIVILISATION CHI
   Ni XJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099377
   Porkert M, 1993, NEUES LEHRBUCH CHINE
   Porkert M, 1991, THEORETISCHEN GRUNDL
   Porkert M, 1985, SYSTEMATISCHE AKUPUN
   Ramsay DJ, 1998, JAMA-J AM MED ASSOC, V280, P1518
   RATHBONE J, 2005, COCHRANE DB SYST REV, V4
   Scheid V., 2009, Chinese Herbal Medicine: Formulas and Strategies, V2nd edn
   Scheid Volker., 2007, CURRENTS TRADITION C, V1st
   SHEEHAN MP, 1992, LANCET, V340, P13, DOI 10.1016/0140-6736(92)92424-E
   Sun YY, 2009, ANTI-CANCER DRUG, V20, P757, DOI 10.1097/CAD.0b013e328330d95b
   Unschuld PaulU., 1985, MED CHINA HIST IDEAS
   Wang G, 2005, COCHRANE DB SYST REV, V1, pCD003631
   Wayne PM, 2014, J AM GERIATR SOC, V62, P25, DOI 10.1111/jgs.12611
   Wiebrecht A, 2017, LEITFADEN CHINESISCH
   World Federation of Chinese Medicine Societies, 2017, UB INT STAND CHIN ME
   Yuan W., 2008, COCHRANE DB SYST REV, V2, DOI DOI 10.1002/14651858.CD006335.PUB2
   Zhang X, 2007, COCHRANE DATABASE SY, V1
   Zhu X, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005288.pub2
NR 53
TC 10
Z9 14
U1 5
U2 29
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1436-9990
EI 1437-1588
J9 BUNDESGESUNDHEITSBLA
JI Bundesgesundheitsblatt-Gesund.
PD MAY
PY 2020
VL 63
IS 5
SI SI
BP 570
EP 576
DI 10.1007/s00103-020-03132-9
EA APR 2020
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA LI5NW
UT WOS:000524385000002
PM 32266491
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Szymoniuk, M
   Chin, JH
   Domagalski, L
   Biszewski, M
   Józwik, K
   Kamieniak, P
AF Szymoniuk, Michal
   Chin, Jia-Hsuan
   Domagalski, Lukasz
   Biszewski, Mateusz
   Jozwik, Katarzyna
   Kamieniak, Piotr
TI Brain stimulation for chronic pain management: a narrative review of
   analgesic mechanisms and clinical evidence
SO NEUROSURGICAL REVIEW
LA English
DT Review
DE Chronic pain; Treatment; Deep brain stimulation; Motor cortex
   stimulation; Non-invasive brain stimulation
ID MOTOR CORTEX STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; CRANIAL
   ELECTROTHERAPY STIMULATION; CHRONIC NEUROPATHIC PAIN;
   SPINAL-CORD-INJURY; DEEP BRAIN; DOUBLE-BLIND; ELECTRICAL-STIMULATION;
   FOLLOW-UP; CLUSTER HEADACHE
AB Chronic pain constitutes one of the most common chronic complaints that people experience. According to the International Association for the Study of Pain, chronic pain is defined as pain that persists or recurs longer than 3 months. Chronic pain has a significant impact on individuals' well-being and psychosocial health and the economy of healthcare systems as well. Despite the availability of numerous therapeutic modalities, treatment of chronic pain can be challenging. Only about 30% of individuals with non-cancer chronic pain achieve improvement from standard pharmacological treatment. Therefore, numerous therapeutic approaches were proposed as a potential treatment for chronic pain including non-opioid pharmacological agents, nerve blocks, acupuncture, cannabidiol, stem cells, exosomes, and neurostimulation techniques. Although some neurostimulation methods such as spinal cord stimulation were successfully introduced into clinical practice as a therapy for chronic pain, the current evidence for brain stimulation efficacy in the treatment of chronic pain remains unclear. Hence, this narrative literature review aimed to give an up-to-date overview of brain stimulation methods, including deep brain stimulation, motor cortex stimulation, transcranial direct current stimulation, repetitive transcranial magnetic stimulation, cranial electrotherapy stimulation, and reduced impedance non-invasive cortical electrostimulation as a potential treatment for chronic pain.
C1 [Szymoniuk, Michal; Chin, Jia-Hsuan; Domagalski, Lukasz; Biszewski, Mateusz; Jozwik, Katarzyna] Med Univ Lublin, Dept Neurosurg, Student Sci Assoc, Lublin, Poland.
   [Kamieniak, Piotr] Med Univ Lublin, Dept Neurosurg, Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin
RP Domagalski, L (corresponding author), Med Univ Lublin, Dept Neurosurg, Student Sci Assoc, Lublin, Poland.
EM lukdom4@gmail.com
RI ; Szymoniuk, Michał/GON-5200-2022; Jóźwik, Katarzyna/GZG-5255-2022
OI Domagalski, Łukasz/0000-0001-6910-4607; Szymoniuk,
   Michał/0000-0001-6061-8089; Biszewski, Mateusz
   Józef/0000-0003-3082-6420; Chin, Jia-Hsuan/0000-0003-4722-8240; 
CR Abreu V, 2022, NEUROCHIRURGIE, V68, P52, DOI 10.1016/j.neuchi.2021.06.006
   Ahn H, 2020, J CLIN NEUROSCI, V77, P128, DOI 10.1016/j.jocn.2020.05.003
   Ahn H, 2017, BRAIN STIMUL, V10, P902, DOI 10.1016/j.brs.2017.05.007
   Alamri A, 2022, NEUROSURG CLIN N AM, V33, P311, DOI 10.1016/j.nec.2022.02.013
   André-Obadia N, 2014, PAIN PHYSICIAN, V17, P53
   [Anonymous], 2022, MEDTR ANN FDA APPR S
   Ansari AH, 2021, ACS CHEM NEUROSCI, V12, P256, DOI 10.1021/acschemneuro.0c00785
   Antony AB, 2019, PAIN PHYSICIAN, V22, P447, DOI 10.36076/ppj/2019.22.447
   Attal N, 2021, REV NEUROL-FRANCE, V177, P606, DOI 10.1016/j.neurol.2020.07.003
   Avery N., 2022, BMJ, V4, P377
   Ayache SS, 2016, FRONT NEUROSCI-SWITZ, V10, DOI 10.3389/fnins.2016.00147
   Baethge C, 2019, RES INTEGR PEER REV, V4, DOI 10.1186/s41073-019-0064-8
   Bai Y, 2017, NEUROIMAGE-CLIN, V15, P702, DOI 10.1016/j.nicl.2017.01.025
   Belasen A, 2017, J NEUROSURG, V126, P397, DOI 10.3171/2016.2.JNS152231
   Bergeron D, 2021, BRAIN SCI, V11, DOI 10.3390/brainsci11050639
   Bicego A, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0256001
   Bielewicz J, 2023, J CLIN MED, V12, DOI 10.3390/jcm12041380
   Boggio PS, 2009, CLIN J PAIN, V25, P691, DOI 10.1097/AJP.0b013e3181af1414
   Breivik H, 2006, EUR J PAIN, V10, P287, DOI 10.1016/j.ejpain.2005.06.009
   Brietzke AP, 2016, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00498
   Brunoni AR, 2017, BRAIN STIMUL, V10, P260, DOI 10.1016/j.brs.2016.11.005
   Brunye TT., 2021, Frontiers in Human Neuroscience, V1, P12
   Buchanan RJ, 2014, NEUROREPORT, V25, P715, DOI 10.1097/WNR.0000000000000174
   Bursali C, 2021, PAIN PHYSICIAN, V24, pE23
   Cha M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-08208-2
   Chang WJ., 2017, PLOS ONE, V12, P6
   Ching PY., 2022, FRONT PSYCHIATRY, V9, P13
   Choi GS, 2018, J REHABIL MED, V50, P246, DOI 10.2340/16501977-2321
   Choi GS, 2018, INT J NEUROSCI, V128, P110, DOI 10.1080/00207454.2017.1367682
   Chung CLH, 2020, ANN NEUROL, V88, P933, DOI 10.1002/ana.25881
   Cohen SP, 2021, LANCET, V397, P2082, DOI 10.1016/S0140-6736(21)00393-7
   Dahlhamer J, 2018, MMWR-MORBID MORTAL W, V67, P1001, DOI 10.15585/mmwr.mm6736a2
   Dale R, 2016, MED CLIN N AM, V100, P55, DOI 10.1016/j.mcna.2015.08.012
   De Risio L, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-01055-2
   Deer TR, 2019, BRAIN SCI, V9, DOI 10.3390/brainsci9020023
   Delavallée M, 2014, ACTA NEUROCHIR, V156, P2289, DOI 10.1007/s00701-014-2240-4
   Deuschl G, 2013, NEW ENGL J MED, V368, P2038, DOI 10.1056/NEJMc1303485
   Soler MD, 2010, BRAIN, V133, P2565, DOI 10.1093/brain/awq184
   Dondé C, 2017, PROG NEURO-PSYCHOPH, V78, P123, DOI 10.1016/j.pnpbp.2017.05.021
   Donnell A, 2015, BRAIN STIMUL, V8, P1085, DOI 10.1016/j.brs.2015.06.008
   Doyal A., 2022, StatPearls
   Els C., 2017, COCHRANE DB SYST REV, V10, P10
   FEIGHNER JP, 1973, J NERV MENT DIS, V157, P121, DOI 10.1097/00005053-197308000-00004
   Fitzgibbon BM, 2018, EUR J PAIN, V22, P1255, DOI 10.1002/ejp.1213
   Fontaine D, 2010, J HEADACHE PAIN, V11, P23, DOI 10.1007/s10194-009-0169-4
   Fontaine D, 2009, J NEUROSURG, V110, P251, DOI 10.3171/2008.6.17602
   Fregni F, 2018, BRAIN STIMUL, V11, P299, DOI 10.1016/j.brs.2017.11.009
   Fregni F, 2006, ARTHRITIS RHEUM-US, V54, P3988, DOI 10.1002/art.22195
   Fregni F, 2006, PAIN, V122, P197, DOI 10.1016/j.pain.2006.02.023
   Freire RC, 2020, ADV EXP MED BIOL, V1191, P331, DOI 10.1007/978-981-32-9705-0_18
   Fricová J, 2013, PHYSIOL RES, V62, pS125, DOI 10.33549/physiolres.932575
   Gabis L, 2009, J REHABIL MED, V41, P256, DOI 10.2340/16501977-0315
   Galletta EE, 2011, TOP STROKE REHABIL, V18, P87, DOI 10.1310/tsr1802-87
   George B, 2019, SUPPORT CARE CANCER, V27, P3105, DOI 10.1007/s00520-019-04828-8
   Gopalakrishnan R, 2018, J NEUROPHYSIOL, V119, P2118, DOI 10.1152/jn.00830.2017
   Grider J, 2016, PAIN PHYSICIAN, V19, pE33, DOI 10.36076/ppj/2016.19.e33
   Gruber D, 2018, BRAIN STIMUL, V11, P1368, DOI 10.1016/j.brs.2018.08.006
   Hagenacker T, 2014, J HEADACHE PAIN, V15, DOI 10.1186/1129-2377-15-78
   Hamani C, 2021, BRAIN, V144, P2994, DOI 10.1093/brain/awab189
   Hargrove JB, 2012, PAIN MED, V13, P115, DOI 10.1111/j.1526-4637.2011.01292.x
   Harvey MP, 2017, CLIN INTERV AGING, V12, P937, DOI 10.2147/CIA.S133423
   Hazime FA, 2017, EUR J PAIN, V21, P1132, DOI 10.1002/ejp.1037
   Helm S, 2021, PAIN THER, V10, P985, DOI 10.1007/s40122-021-00306-4
   Henssen D, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-64177-z
   Henssen DJHA, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191774
   Hylands-White N, 2017, RHEUMATOL INT, V37, P29, DOI 10.1007/s00296-016-3481-8
   Im SH, 2015, STEREOT FUNCT NEUROS, V93, P212, DOI 10.1159/000381557
   Inst Med, 2011, RELIEVING PAIN IN AMERICA: A BLUEPRINT FOR TRANSFORMING PREVENTION, CARE, EDUCATION, AND RESEARCH, P1
   Isagulyan E D, 2015, Zh Vopr Neirokhir Im N N Burdenko, V79, P46, DOI [10.17116/neiro201579646-60, 10.17116/neiro201579646-60]
   Ivanishvili Z, 2017, NEUROMODULATION, V20, P497, DOI 10.1111/ner.12610
   Jensen MP, 2013, CLIN NEUROPHYSIOL, V124, P2016, DOI 10.1016/j.clinph.2013.04.009
   Jiang WL, 2022, ASIAN J PSYCHIATR, V73, DOI 10.1016/j.ajp.2022.103100
   Kalso E, 2004, PAIN, V112, P372, DOI 10.1016/j.pain.2004.09.019
   Kang HW, 2020, J INT MED RES, V48, DOI 10.1177/0300060520939370
   Katta MR, 2022, J ONCOL PHARM PRACT, V28, P1859, DOI 10.1177/10781552221098437
   Kaye AD, 2018, CURR PAIN HEADACHE R, V22, DOI 10.1007/s11916-018-0674-8
   Khedr EM, 2017, BRAIN STIMUL, V10, P893, DOI 10.1016/j.brs.2017.06.006
   Kim YJ, 2013, ANN REHABIL MED-ARM, V37, P766, DOI 10.5535/arm.2013.37.6.766
   Kirsch DL, 2013, PSYCHIAT CLIN N AM, V36, P169, DOI 10.1016/j.psc.2013.01.006
   Klein J, 2020, J NEUROSURG, V134, P1244, DOI 10.3171/2019.12.JNS192261
   Knotkova H, 2021, LANCET, V397, P2111, DOI 10.1016/S0140-6736(21)00794-7
   Kogan M, 2019, NEUROSURG CLIN N AM, V30, P137, DOI 10.1016/j.nec.2019.01.001
   Komatsu T, 2022, J NEUROL SCI, V443, DOI 10.1016/j.jns.2022.120473
   Kumar A, 2021, NEUROL SCI, V42, P131, DOI 10.1007/s10072-020-04505-3
   Kustermans L, 2017, J CRANIO MAXILL SURG, V45, P39, DOI 10.1016/j.jcms.2016.10.014
   Lagueux É, 2018, CLIN J PAIN, V34, P145, DOI 10.1097/AJP.0000000000000522
   Lanska DJ, 2002, NEUROLOGY, V58, P452, DOI 10.1212/WNL.58.3.452
   Lefaucheur JP, 2014, CLIN NEUROPHYSIOL, V125, P2150, DOI 10.1016/j.clinph.2014.05.021
   Lempka SF, 2017, ANN NEUROL, V81, P653, DOI 10.1002/ana.24927
   Lenoir C, 2018, J PHYSIOL-LONDON, V596, P4767, DOI 10.1113/JP276359
   Leung A, 2016, NEUROMODULATION, V19, P133, DOI 10.1111/ner.12364
   Li JP, 2021, PAIN PHYSICIAN, V24, P533
   LIPPOLD OCJ, 1964, BRIT J PSYCHIAT, V110, P768, DOI 10.1192/bjp.110.469.768
   Litak J, 2022, CANCERS, V14, DOI 10.3390/cancers14194599
   Lubejko ST., 2022, FRONT SYST NEUROSCI, V14, P132
   Luedtke K., 2015, BMJ, V16, P350
   Ma QY, 2023, INT J CLIN HLTH PSYC, V23, DOI 10.1016/j.ijchp.2022.100355
   Maarrawi J, 2007, NEUROLOGY, V69, P827, DOI 10.1212/01.wnl.0000269783.86997.37
   Marques A, 2013, NEUROLOGY, V81, P633, DOI 10.1212/WNL.0b013e3182a08d00
   Martin DM, 2011, J AFFECT DISORDERS, V134, P459, DOI 10.1016/j.jad.2011.05.018
   Mattoo B, 2019, INDIAN J MED RES, V150, P73, DOI 10.4103/ijmr.IJMR_97_18
   Meints SM, 2018, PROG NEURO-PSYCHOPH, V87, P168, DOI 10.1016/j.pnpbp.2018.01.017
   Mendonca ME, 2016, FRONT HUM NEUROSCI, V10, DOI 10.3389/fnhum.2016.00068
   Mills SEE, 2019, BRIT J ANAESTH, V123, pE273, DOI 10.1016/j.bja.2019.03.023
   Mischoulon D, 2015, J PSYCHIATR RES, V70, P98, DOI 10.1016/j.jpsychires.2015.08.016
   Moisset X, 2021, REV NEUROL-FRANCE, V177, P834, DOI 10.1016/j.neurol.2021.07.004
   Moisset X, 2020, J NEURAL TRANSM, V127, P673, DOI 10.1007/s00702-019-02092-y
   Mori F, 2010, J PAIN, V11, P436, DOI 10.1016/j.jpain.2009.08.011
   Navarro-López V, 2022, EUR J PHYS REHAB MED, V58, P738, DOI 10.23736/S1973-9087.22.07439-1
   Nevro Corp, NEVR ANN FDA APPR IT
   Ngernyam N, 2015, CLIN NEUROPHYSIOL, V126, P382, DOI 10.1016/j.clinph.2014.05.034
   Nicholas M, 2019, PAIN, V160, P28, DOI 10.1097/j.pain.0000000000001390
   Nurmikko T, 2016, NEUROMODULATION, V19, P669, DOI 10.1111/ner.12444
   O'Connell NE., 2018, COCHRANE DB SYST REV, V4, P4
   O'Neill F, 2018, J PAIN RES, V11, P3117, DOI 10.2147/JPR.S186079
   Ojala J, 2022, NEUROMODULATION, V25, P538, DOI 10.1111/ner.13496
   Ostergard T, 2014, NEUROSURG CLIN N AM, V25, P693, DOI 10.1016/j.nec.2014.06.004
   Pagano RL, 2012, PAIN, V153, P2359, DOI 10.1016/j.pain.2012.08.002
   Parravano DC, 2019, NEUROSURGERY, V84, P451, DOI 10.1093/neuros/nyy060
   Poreisz C, 2007, BRAIN RES BULL, V72, P208, DOI 10.1016/j.brainresbull.2007.01.004
   Quesada C, 2020, PAIN, V161, P718, DOI 10.1097/j.pain.0000000000001760
   Radic JAE, 2015, CAN J NEUROL SCI, V42, P401, DOI 10.1017/cjn.2015.292
   Ramos-Fresnedo A, 2022, NEUROMODULATION, V25, P211, DOI 10.1016/j.neurom.2021.10.025
   Rapisarda A, 2021, EUR NEUROL, V84, P151, DOI 10.1159/000514827
   Rasche D, 2016, NEUROSURGERY, V79, P655, DOI 10.1227/NEU.0000000000001353
   Ren JX, 2019, CURR STEM CELL RES T, V14, P644, DOI 10.2174/1574888X14666190912162504
   Rintala DH, 2010, PARKINSONS DIS-US, V2010, DOI 10.4061/2010/569154
   Sabbagh M, 2020, ALZHEIMERS DEMENT, V16, P641, DOI 10.1016/j.jalz.2019.08.197
   Sachs AJ, 2014, NEUROMODULATION, V17, P303, DOI 10.1111/ner.12181
   Säisänen L, 2022, NEUROPHYSIOL CLIN, V52, P95, DOI 10.1016/j.neucli.2022.03.001
   Sakrajai P, 2014, CLIN J PAIN, V30, P1076, DOI 10.1097/AJP.0000000000000069
   Sanger TD, 2020, DEV MED CHILD NEUROL, V62, P28, DOI 10.1111/dmcn.14295
   Saxena V, 2021, CLIN PSYCHOPHARM NEU, V19, P589, DOI 10.9758/cpn.2021.19.4.589
   Schoenen J, 2013, CEPHALALGIA, V33, P816, DOI 10.1177/0333102412473667
   Shekelle P., 2018, EFF RISKS CRANIAL EL
   Shekelle PG, 2018, ANN INTERN MED, V168, P414, DOI 10.7326/M17-1970
   Shirvalkar P, 2018, FRONT COMPUT NEUROSC, V12, DOI 10.3389/fncom.2018.00018
   Silva GD, 2015, J NEUROINFLAMM, V12, DOI 10.1186/s12974-014-0216-1
   Sims-Williams H, 2017, NEUROIMAGE, V146, P833, DOI 10.1016/j.neuroimage.2016.08.038
   Sluka KA, 2016, NEUROSCIENCE, V338, P114, DOI 10.1016/j.neuroscience.2016.06.006
   Sobstyl M, 2020, SEIZURE-EUR J EPILEP, V81, P58, DOI 10.1016/j.seizure.2020.07.022
   Sokal P, 2019, J PAIN RES, V12, P1863, DOI 10.2147/JPR.S195867
   Sokal P, 2015, ADV CLIN EXP MED, V24, P289, DOI 10.17219/acem/40452
   Son BC, 2014, STEREOT FUNCT NEUROS, V92, P218, DOI 10.1159/000362933
   Sonmez AI, 2019, PSYCHIAT RES, V273, P770, DOI 10.1016/j.psychres.2018.12.041
   Souto G, 2014, CLIN J PAIN, V30, P809, DOI 10.1097/AJP.0000000000000037
   De Souza CG, 2021, BRAIN STIMUL, V14, P541, DOI 10.1016/j.brs.2021.02.015
   Lopes PSS, 2019, BEHAV BRAIN FUNCT, V15, DOI 10.1186/s12993-019-0156-0
   Szewczyk AK, 2023, DIAGNOSTICS, V13, DOI 10.3390/diagnostics13010108
   Szymoniuk M, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12010120
   Tan G, 2011, J SPINAL CORD MED, V34, P285, DOI 10.1179/2045772311Y.0000000008
   Tanei T, 2018, NEUROL MED-CHIR, V58, P422, DOI 10.2176/nmc.oa.2018-0106
   Taylor AG, 2013, PAIN MANAG NURS, V14, P327, DOI 10.1016/j.pmn.2011.07.002
   Thair H, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00641
   Thibaut A, 2017, NEUROSCI LETT, V658, P19, DOI 10.1016/j.neulet.2017.08.024
   Treede RD, 2015, PAIN, V156, P1003, DOI 10.1097/j.pain.0000000000000160
   Tronnier V, 2013, Handb Clin Neurol, V116, P343, DOI 10.1016/B978-0-444-53497-2.00028-0
   TSUBOKAWA T, 1991, PACE, V14, P131, DOI 10.1111/j.1540-8159.1991.tb04058.x
   Umezaki Y, 2016, BRAIN STIMUL, V9, P234, DOI 10.1016/j.brs.2015.10.005
   Urits I, 2020, BEST PRAC RES-CL ANA, V34, P463, DOI 10.1016/j.bpa.2020.06.004
   Uzair M, 2022, NEURAL REGEN RES, V17, P251, DOI 10.4103/1673-5374.317962
   van Dun K, 2016, FRONT HUM NEUROSCI, V10, DOI 10.3389/fnhum.2016.00199
   VENTAFRIDDA V, 1985, INT J TISSUE REACT, V7, P93
   Villamar MF, 2013, J PAIN, V14, P371, DOI 10.1016/j.jpain.2012.12.007
   Volz MS, 2016, PAIN, V157, P429, DOI 10.1097/j.pain.0000000000000386
   Winkelmueller M, 2016, J NEUROL SURG PART A, V77, P63, DOI [10.1055/s-0035-1558419, 10.1055/s-0035-1558419, 10.1055/s-0035-1547362]
   Woods AJ, 2016, CLIN NEUROPHYSIOL, V127, P1031, DOI 10.1016/j.clinph.2015.11.012
   Wrigley PJ, 2013, PAIN, V154, P2178, DOI 10.1016/j.pain.2013.06.045
   Wylde V, 2017, BJS-BRIT J SURG, V104, P1293, DOI 10.1002/bjs.10601
   Xiong HY., 2022, FRONT MOL NEUROSCI, V26, P15
   Yang L, 2018, CURR MED SCI, V38, P482, DOI 10.1007/s11596-018-1904-3
   Yennurajalingam S, 2018, J PAIN SYMPTOM MANAG, V55, P198, DOI 10.1016/j.jpainsymman.2017.08.027
   Yokoi Y, 2018, CLIN EEG NEUROSCI, V49, P93, DOI 10.1177/1550059417732247
   Yong RJ, 2022, PAIN, V163, pE328, DOI 10.1097/j.pain.0000000000002291
   Yu BB, 2020, AM J PHYS MED REHAB, V99, P811, DOI 10.1097/PHM.0000000000001421
   Zhang HJ, 2022, CURR ONCOL REP, V24, P223, DOI 10.1007/s11912-021-01166-z
   Zhang XL, 2018, STEREOT FUNCT NEUROS, V96, P239, DOI 10.1159/000492056
   Zhang XL, 2017, NEUROMODULATION, V20, P492, DOI 10.1111/ner.12547
   Zhao RH, 2018, FRONT CELL NEUROSCI, V12, DOI 10.3389/fncel.2018.00107
   Zhuo M, 2016, TRENDS NEUROSCI, V39, P136, DOI 10.1016/j.tins.2016.01.006
NR 180
TC 16
Z9 22
U1 3
U2 22
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0344-5607
EI 1437-2320
J9 NEUROSURG REV
JI Neurosurg. Rev.
PD MAY 29
PY 2023
VL 46
IS 1
AR 127
DI 10.1007/s10143-023-02032-1
PG 32
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA H8WZ4
UT WOS:000998711900001
PM 37247036
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Casazza, BA
AF Casazza, Brian A.
TI Diagnosis and Treatment of Acute Low Back Pain
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID SPINAL MANIPULATIVE THERAPY; MCKENZIE METHOD; LUMBAR SPINE; CARE;
   ACUPUNCTURE; PREVALENCE; RECURRENCE; COSTS; TRIAL; HEAT
AB Acute low back pain is one of the most common reasons for adults to see a family physician. Although most patients recover quickly with minimal treatment, proper evaluation is imperative to identify rare cases of serious underlying pathology. Certain red flags should prompt aggressive treatment or referral to a spine specialist, whereas others are less concerning. Serious red flags include significant trauma related to age (i.e., injury related to a fall from a height or motor vehicle crash in a young patient, or from a minor fall or heavy lifting in a patient with osteoporosis or possible osteoporosis), major or progressive motor or sensory deficit, new-onset bowel or bladder incontinence or urinary retention, loss of anal sphincter tone, saddle anesthesia, history of cancer metastatic to bone, and suspected spinal infection. Without clinical signs of serious pathology, diagnostic imaging and laboratory testing often are not required. Although there are numerous treatments for nonspecific acute low back pain, most have little evidence of benefit. Patient education and medications such as nonsteroidal anti-inflammatory drugs, acetaminophen, and muscle relaxants are beneficial. Bed rest should be avoided if possible. Exercises directed by a physical therapist, such as the McKenzie method and spine stabilization exercises, may decrease recurrent pain and need for health care services. Spinal manipulation and chiropractic techniques are no more effective than established medical treatments, and adding them to established treatments does not improve outcomes. No substantial benefit has been shown with oral steroids, acupuncture, massage, traction, lumbar supports, or regular exercise programs. (Am Fam Physician. 2012;85(4):343-350. Copyright (C) 2012 American Academy of Family Physicians.)
C1 [Casazza, Brian A.] Univ N Carolina, Sch Med, Spine Ctr Chapel Hill, Chapel Hill, NC 27599 USA.
   [Casazza, Brian A.] Univ N Carolina, Sch Med, Dept Phys Med & Rehabil, Chapel Hill, NC 27599 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina School of Medicine
RP Casazza, BA (corresponding author), Univ N Carolina, Sch Med, Spine Ctr Chapel Hill, 101 Manning Dr,CB 7200, Chapel Hill, NC 27599 USA.
EM brian_casazza@med.unc.edu
CR Acosta Frank L Jr, 2006, Curr Infect Dis Rep, V8, P390, DOI 10.1007/s11908-006-0050-4
   [Anonymous], 2008, COCHRANE DATABASE SY
   Assendelft WJ, 2004, COCHRANE DB SYST REV, V1, DOI DOI 10.1002/14651858.CD000447.PUB2
   Becker A, 2010, SPINE, V35, P1714, DOI 10.1097/BRS.0b013e3181cd656f
   BODEN SD, 1990, J BONE JOINT SURG AM, V72A, P403, DOI 10.2106/00004623-199072030-00013
   Carey TS, 1999, MED CARE, V37, P157, DOI 10.1097/00005650-199902000-00006
   CAREY TS, 1995, NEW ENGL J MED, V333, P913, DOI 10.1056/NEJM199510053331406
   Casazza BA, 1998, OCCUP MED, V13, P47
   Cheung KMC, 2009, SPINE, V34, P934, DOI 10.1097/BRS.0b013e3181a01b3f
   Choi BKL, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006555.pub2
   Chou R, 2009, LANCET, V373, P463, DOI 10.1016/S0140-6736(09)60172-0
   Cifuentes M, 2010, PAIN, V151, P22, DOI 10.1016/j.pain.2010.04.012
   Clarke JA, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003010.pub4
   Dahm KT, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007612.pub2
   Davis PC, AM COLL RADIOLOGY AC
   Engers A, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004057.pub3
   French SD, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004750.pub2
   Fritz JM, 2008, SPINE, V33, P1800, DOI 10.1097/BRS.0b013e31817bd853
   FRYMOYER JW, 1988, NEW ENGL J MED, V318, P291, DOI 10.1056/NEJM198802043180506
   Furlan AD, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001351.pub2
   Furlan AD, 2009, SPINE, V34, P1669, DOI 10.1097/BRS.0b013e3181ad7bd6
   Gellhorn AC, SPINE PHILA PA 1976
   Hagen KB., 2004, Cochrane Database Syst Rev, DOI [10.1002/14651858.CD001254.pub2, DOI 10.1002/14651858.CD001254.PUB2]
   Hancock MJ, 2007, LANCET, V370, P1638, DOI 10.1016/S0140-6736(07)61686-9
   Hancock MJ, 2009, CLIN J PAIN, V25, P659, DOI 10.1097/AJP.0b013e3181a7ee3a
   Hayden JA, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD000335.pub2
   Henschke N, 2009, ARTHRITIS RHEUM-US, V60, P3072, DOI 10.1002/art.24853
   Hides J A, 2001, Spine (Phila Pa 1976), V26, pE243, DOI 10.1097/00007632-200106010-00004
   Hoiriis KT, 2004, J MANIP PHYSIOL THER, V27, P388, DOI 10.1016/j.jmpt.2004.05.003
   Holve RL, 2008, J AM BOARD FAM MED, V21, P469, DOI 10.3122/jabfm.2008.05.070220
   Institute for Clinical Systems Improvement, 2010, AD LOW BACK PAIN GUI
   JENSEN MC, 1994, NEW ENGL J MED, V331, P69, DOI 10.1056/NEJM199407143310201
   Jüni P, 2009, ANN RHEUM DIS, V68, P1420, DOI 10.1136/ard.2008.093757
   Kennedy S, 2008, COMPLEMENT THER MED, V16, P139, DOI 10.1016/j.ctim.2007.03.001
   Lau PMY, 2008, AUST J PHYSIOTHER, V54, P243
   Lin CWC, 2011, EUR SPINE J, V20, P1024, DOI 10.1007/s00586-010-1676-3
   Machado LAC, 2006, SPINE, V31, pE254, DOI 10.1097/01.brs.0000214884.18502.93
   Machado LAC, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-10
   McIntosh G, CLIN EVIDENCE LOW BA
   Roberts ST, 2009, PM&R, V1, P657, DOI 10.1016/j.pmrj.2009.04.008
   Stanton TR, 2008, SPINE, V33, P2923, DOI 10.1097/BRS.0b013e31818a3167
   Tao XG, 2005, J OCCUP ENVIRON MED, V47, P1298, DOI 10.1097/01.jom.0000184877.01691.a3
   Van Duijvenbode ICD, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001823.pub3
   van Tulder M W, 2003, Cochrane Database Syst Rev, pCD004252
   Walker BF, 2011, SPINE, V36, P230, DOI 10.1097/BRS.0b013e318202ac73
   Webster BS, 2010, J OCCUP ENVIRON MED, V52, P900, DOI 10.1097/JOM.0b013e3181ef7e53
NR 46
TC 117
Z9 159
U1 0
U2 52
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD FEB 15
PY 2012
VL 85
IS 4
BP 343
EP 350
PG 8
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 980AZ
UT WOS:000306867300008
PM 22335313
DA 2026-01-16
ER

PT J
AU Araújo, LG
   Lima, DMF
   Sampaio, RF
   Pereira, LSM
AF Araujo, Louise G.
   Lima, Debora M. F.
   Sampaio, Rosana F.
   Pereira, Leani S. M.
TI Pain Locus of control scale: adaptation and reliability for
   elderly
SO BRAZILIAN JOURNAL OF PHYSICAL THERAPY
LA English
DT Article
DE pain control; reliability; cross-cultural adaptation; elderly
ID MULTIDIMENSIONAL HEALTH LOCUS; STRATEGIES; EFFICACY
AB Background: Pain is considered a multidimensional experience and is very common in the elderly. The pain locus of control has become essential to understand how the perceptions, expectations and beliefs are related to individual behavior, attitudes, coping and adherence of the elderly with regards to the health conditions and with the proposed treatment. Studies focused on adaptation and reliability of instruments are necessary for health professionals. Objectives: The present study performed the cross-cultural adaptation of the Pain Locus of Control Scale (C form of Multidimensional Health Locus of Control) for Brazil and assessed its intra and inter-examiner reliability among a sample of 68 elderly individuals with non-oncological pain living in the community. Methods: The cross-cultural adaptation of the scale was performed using the methodology standardized by Beaton et al. (2000)*. Pearson's correlation coefficient (PCC) and the intraclass correlation coefficient (ICC) were used for the statistical analysis (p=0.05). Results: Average age of the subjects was 69.6 +/- 5.5 years; most were women, with low levels of income and education. The average pain duration was 10.2 years and the main clinical diagnosis was osteoarthritis. The reliability of the scale was adequate, with a regular to very strong correlations (PCC = 0.60 to 0.93) and a moderate to nearly perfect ICC (0.60 to 0.93), in mainly the chance locus of control and medical and healthcare professionals locus of control subscales. Conclusion: An adequate reliability and applicability was observed in our sample after adjustments and adaptations of the scale for use in elderly
C1 [Araujo, Louise G.] Ctr Univ Belo Horizonte UniBH, Dept Phys Therapy, Belo Horizonte, MG, Brazil.
   [Sampaio, Rosana F.; Pereira, Leani S. M.] Univ Fed Minas Gerais, Sch Phys Educ Phys Therapy & Occupat Therapy, Dept Phys Therapy, Belo Horizonte, MG, Brazil.
C3 Centro Universitario de Belo Horizonte; Universidade Federal de Minas
   Gerais
RP Araújo, LG (corresponding author), Rua Perdigao 67,Apto 404, BR-31910190 Belo Horizonte, MG, Brazil.
EM lgara@terra.com.br
RI PEREIRA, LSM/L-2541-2014
CR Andrade Mônica, 2006, Rev. psiquiatr. Rio Gd. Sul, V28, P144, DOI 10.1590/S0101-81082006000200007
   [Anonymous], ESTATISTICA BASICA C
   Barry LC, 2005, J GERONTOL A-BIOL, V60, P1569, DOI 10.1093/gerona/60.12.1569
   Beaton DE, 2000, SPINE, V25, P3186, DOI 10.1097/00007632-200012150-00014
   Beissner K, 2009, PHYS THER, V89, P456, DOI 10.2522/ptj.20080163
   BERTOLUCCI PHF, 1994, ARQ NEURO-PSIQUIAT, V52, P1, DOI 10.1590/S0004-282X1994000100001
   Blumstein H, 2005, GERIATRICS, V60, P28
   Coughlin AM, 2000, ARCH PHYS MED REHAB, V81, P739, DOI 10.1016/S0003-9993(00)90103-5
   Cross MJ, 2006, RHEUMATOLOGY, V45, P92, DOI 10.1093/rheumatology/kei114
   Dela Coleta M, 2004, MODELOS PESQUISA MOD, P199
   Geertzen JHB, 2006, DISABIL REHABIL, V28, P363, DOI 10.1080/09638280500287437
   Gibson SJ, 2000, PAIN, V85, P375, DOI 10.1016/S0304-3959(99)00284-5
   Dellaroza MSG, 2007, CAD SAUDE PUBLICA, V23, P1151, DOI 10.1590/S0102-311X2007000500017
   Harris T, 2006, AGE AGEING, V35, P25, DOI 10.1093/ageing/afi216
   Herning Margaret M, 2005, J Geriatr Phys Ther, V28, P34
   LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
   Luszczynska A, 2005, J HEALTH PSYCHOL, V10, P633, DOI 10.1177/1359105305055307
   Monsivais D, 2007, PAIN MANAG NURS, V8, P64, DOI 10.1016/j.pmn.2007.03.001
   PAINE P, 1994, PSYCHOL REP, V75, P91, DOI 10.2466/pr0.1994.75.1.91
   Perez RSGM, 2006, DISABIL REHABIL, V28, P339, DOI 10.1080/09638280500287247
   Rodríguez-Rosero Jesús Edilberto, 2002, Rev. Latino-Am. Enfermagem, V10, P179, DOI 10.1590/S0104-11692002000200009
   Rotter J., 2006, Teorias da personalidade, V1a, P414
   Salvetti Marina de Góes, 2005, Arch. Clin. Psychiatry (São Paulo), V32, P202
   Samwel HJA, 2006, CLIN J PAIN, V22, P245, DOI 10.1097/01.ajp.0000173019.72365.f5
   Santos CC., 2006, Acta fisiatrica, V13, P75, DOI [10.11606/issn.2317-0190.v13i2a102586, DOI 10.11606/ISSN.2317-0190.V13I2A102586]
   SECHREST L, 1972, J CROSS CULT PSYCHOL, V3, P41, DOI 10.1177/002202217200300103
   Tsai YF, 2007, PAIN, V130, P188, DOI 10.1016/j.pain.2007.03.014
   WALLSTON KA, 1994, J PERS ASSESS, V63, P534, DOI 10.1207/s15327752jpa6303_10
   WALLSTON KA, 1978, HEALTH EDUC QUART, V6, P160, DOI 10.1177/109019817800600107
   Wallston KA, 2005, J HEALTH PSYCHOL, V10, P623, DOI 10.1177/1359105305055304
NR 30
TC 10
Z9 12
U1 0
U2 6
PU ASSOCIACAO BRASILEIRA PESQUISA POS-GRADUACAO FISIOTERAPIA-ABRAPG-FT
PI SAO CARLOS SP
PA ROD WASHINGTON LUIS, KM 235, CAIXA POSTAL 676, SAO CARLOS SP,
   CEP13565-905, BRAZIL
SN 1413-3555
EI 1809-9246
J9 BRAZ J PHYS THER
JI Braz. J. Phys. Ther.
PD SEP-OCT
PY 2010
VL 14
IS 5
BP 438
EP 445
DI 10.1590/S1413-35552010000500014
PG 8
WC Orthopedics; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rehabilitation
GA 697JW
UT WOS:000285510900014
PM 21180870
OA Green Submitted, Green Published, hybrid
DA 2026-01-16
ER

PT J
AU Que, B
   Tu, Q
   Shi, JL
   Wan, ZZ
   Li, YA
   Zhou, R
   Yu, H
   Gan, JH
   Yu, JM
AF Que, Bin
   Tu, Qing
   Shi, Jinlin
   Wan, Zhengzuo
   Li, Yanan
   Zhou, Rong
   Yu, Hong
   Gan, Jianhui
   Yu, Jianming
TI Effects of Transcutaneous Electrical Acupoint Stimulation on Systemic
   Inflammatory Response Syndrome of Patients after Percutaneous
   Nephrolithotomy: A Randomized Controlled Trial
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID ELECTROACUPUNCTURE; ACUPUNCTURE; RATS; PAIN
AB Purpose. Transcutaneous electrical acupoint stimulation (TEAS) is widely used. However, no study evaluated TEAS on systemic inflammatory response syndrome (SIRS) of patients after percutaneous nephrolithotomy (PCNL). The study was to evaluate TEAS on SIRS of patients after PCNL. Methods. 67 patients were enrolled and divided into group TEAS and group sham TEAS. Data were collected from 60 participants finally. In the study, TEAS or sham TEAS on bilateral Shenshu (BL23), Yinlingquan (SP9), Hegu (LI4), and Neiguan (PC6) was performed continuously throughout the procedure. The primary outcome included the incidence of systemic inflammatory response syndrome (SIRS) within 48 h after surgery. The secondary outcomes included the serum levels of inflammatory cytokines, hemodynamics changes, complications, and hospital stay after surgery. The serum levels of tumor necrosis factor- (TNF-) alpha and interleukin- (IL-) 6, mean arterial pressure (MAP), and heart rate (HR) at 30 min before anesthesia (T-0), the time after surgery (T-1), 24 h postoperation (T-2), and 48 h postoperation (T-3) were recorded. The consumption of analgesic during surgery was also recorded, as well as the complications and duration of hospital stay after PCNL. Results. The incidence of SIRS in group TEAS was lower than group sham TEAS (30% vs. 6.67%, p=0.023). Compared with the sham TEAS group, both levels of TNF-alpha and IL-6 at T-1, T-2, and T-3 were lower in the TEAS group (p<0.05). The levels of MAP and HR in sham TEAS at T-1, T-2, and T-3 were markedly higher than that in the TEAS group (p<0.05). The total consumption of propofol and remifentanil during surgery in group TEAS was lower than that in the sham TEAS group. The incidence of hypotension, hypertension, emergence agitation, and postoperative nausea and vomiting (PONV) was also lower in group TEAS after PCNL (p<0.05). Conclusions. TEAS could effectively reduce the incidence of SIRS and inflammatory cytokines for patients who underwent PCNL. In addition, TEAS helped to maintain the hemodynamic stability and cut down the consumption of analgesics during PCNL, reducing the complications after PCNL.
C1 [Que, Bin; Wan, Zhengzuo; Li, Yanan; Zhou, Rong; Yu, Jianming] Zhejiang Chinese Med Univ, Dept Anesthesiol, Hangzhou TCM Hosp, Hangzhou 310000, Peoples R China.
   [Tu, Qing] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Anesthesiol, Sch Med, Shanghai 200000, Peoples R China.
   [Shi, Jinlin; Yu, Hong; Gan, Jianhui] North China Univ Sci & Technol, Tangshan Peoples Hosp, Dept Anesthesiol, Tangshan 063000, Hebei, Peoples R China.
C3 Zhejiang Chinese Medical University; Shanghai Jiao Tong University;
   North China University of Science & Technology
RP Yu, JM (corresponding author), Zhejiang Chinese Med Univ, Dept Anesthesiol, Hangzhou TCM Hosp, Hangzhou 310000, Peoples R China.; Gan, JH (corresponding author), North China Univ Sci & Technol, Tangshan Peoples Hosp, Dept Anesthesiol, Tangshan 063000, Hebei, Peoples R China.
EM ganjianhui666@163.com; sjlints@163.com
RI JinLin, Shi/NWH-5237-2025
OI Gan, Jianhui/0000-0002-4946-3554
FU Tangshan Science and Technology Innovation Team Project [18130220A]
FX The authors would like to thank the study investigators and all
   participants. The study was financially supported by grants from the
   Tangshan Science and Technology Innovation Team Project (18130220A).
CR Akbulut F, 2016, SPRINGERPLUS, V5, DOI 10.1186/s40064-016-2830-0
   BONE RC, 1992, CHEST, V101, P1644, DOI 10.1378/chest.101.6.1644
   Chen JB, 2020, INT J SURG, V73, P57, DOI 10.1016/j.ijsu.2019.10.036
   Chen L, 2009, J PAIN, V10, P732, DOI 10.1016/j.jpain.2008.12.012
   El-Deeb AM, 2011, J ANESTH, V25, P698, DOI 10.1007/s00540-011-1198-0
   Gao Junlong, 2015, Zhongguo Zhen Jiu, V35, P269
   Hosseini MM, 2007, J ENDOUROL, V21, P1429, DOI 10.1089/end.2007.0092
   Huang ST, 2005, AM J CHINESE MED, V33, P157, DOI 10.1142/S0192415X0500276X
   Jones AYM, 2011, AM J CRIT CARE, V20, pE67, DOI 10.4037/ajcc2011142
   Kaukonen KM, 2015, NEW ENGL J MED, V372, P1629, DOI 10.1056/NEJMoa1415236
   Kawasaki Y, 2008, J NEUROSCI, V28, P5189, DOI 10.1523/JNEUROSCI.3338-07.2008
   Kim E, 2011, AM J CHINESE MED, V39, P243, DOI 10.1142/S0192415X11008786
   Knoll T, 2017, WORLD J UROL, V35, P1361, DOI 10.1007/s00345-017-2001-0
   Kurdowska A, 2002, CRIT CARE MED, V30, P2335, DOI 10.1097/00003246-200210000-00024
   Li H, 2015, ACUPUNCT MED, V33, P400, DOI 10.1136/acupmed-2014-010752
   Liu CF, 2015, ITAL J PEDIATR, V41, DOI 10.1186/s13052-015-0155-1
   Liu SB, 2020, NEURON, V108, P436, DOI 10.1016/j.neuron.2020.07.015
   Luo S.H., 2009, J TRADIT CHIN MED, V24, P179
   Michel MS, 2007, EUR UROL, V51, P899, DOI 10.1016/j.eururo.2006.10.020
   Mo YC, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/8369737
   Ng MCS, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/neq015
   Olyaei G R, 2004, Electromyogr Clin Neurophysiol, V44, P23
   Omar M, 2016, J UROLOGY, V196, P109, DOI 10.1016/j.juro.2016.01.104
   Qu F, 2017, J ZHEJIANG UNIV-SC B, V18, P186, DOI 10.1631/jzus.B1600437
   Su TF, 2011, MOL PAIN, V7, DOI 10.1186/1744-8069-7-98
   Tu Q, 2019, UROLITHIASIS, V47, P279, DOI 10.1007/s00240-018-1056-8
   Wang GJ, 2015, J ACUPUNCT MERIDIAN, V8, P94, DOI 10.1016/j.jams.2014.10.009
   Wang H, 2014, BRIT J ANAESTH, V112, P1075, DOI 10.1093/bja/aeu001
   Wang H, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/419212
   Xiong LZ, 2007, CHINESE MED J-PEKING, V120, P394, DOI 10.1097/00029330-200703010-00009
   Yoo YC, 2011, YONSEI MED J, V52, P1016, DOI 10.3349/ymj.2011.52.6.1016
   Zhang ZD, 2012, ANESTH ANALG, V114, P879, DOI 10.1213/ANE.0b013e318246536d
   Zijlstra FJ, 2003, MEDIAT INFLAMM, V12, P59, DOI 10.1080/0962935031000114943
NR 33
TC 7
Z9 8
U1 1
U2 18
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD AUG 12
PY 2021
VL 2021
AR 5909956
DI 10.1155/2021/5909956
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA UD8TI
UT WOS:000687474900003
PM 34422076
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Zeng, J
   Yang, YY
AF Zeng, Jin
   Yang, Yuanyuan
TI Diagnosis and treatment of varicella-zoster virus infection with
   herpetic visceral neuralgia without rash: A case report
SO MEDICINE
LA English
DT Article
DE diagnostic therapy; herpes zoster neuralgia; herpetic visceral
   neuralgia; postherpetic neuralgia; varicella-zoster virus
AB Rationale:Herpes zoster (HZ) is an infection caused by the varicella-zoster virus reactivation, often leading to peripheral nervous system infection and pain. This case report aimed to present 2 patients with damaged sensory nerves originating from the visceral neurons of the lateral horn of the spinal cord. Patient concerns:Two patients presented intractable, severe lower back pain and abdominal pain, but without rash or herpes. A female patient was admitted 2 months after symptom onset. She was presented with paroxysmal, acupuncture-like pain in the right upper quadrant and around the umbilicus without apparent incentives. A male patient was presented with recurrent episodes of paroxysmal and spastic colic in the left waist and left middle abdomen for 3 days. Abdominal examination showed no tumors or organic lesions in their intra-abdominal tissues or organs. Diagnoses:After excluding organic lesions on the waist and in abdominal organs, patients were diagnosed with herpetic visceral neuralgia without rash. Intervention:The treatment for herpes zoster neuralgia or postherpetic neuralgia was applied for 3 to 4 weeks. Outcome:Antibacterial and anti-inflammatory analgesics were not effective in either patient. The therapeutic effects of herpes zoster neuralgia or postherpetic neuralgia treatment were satisfactory. Lessons:Herpetic visceral neuralgia can be easily misdiagnosed due to the absence of a rash or herpes, resulting in delayed treatment. When patients have severe, intractable pain but no rash or herpes, and the biochemical and imaging examinations are normal, the treatment method for HZ neuralgia can be used. If the treatment is effective, HZ neuralgia is diagnosed. If not, shingles neuralgia can be ruled out. Further investigations are required to elucidate the mechanisms of pathophysiological changes in varicella-zoster virus-induced peripheral HZ neuralgia or visceral neuralgia without herpes.
C1 [Zeng, Jin] Guangxi Univ Sci & Technol, Affiliated Hosp 1, Dept Anesthesiol, Liuzhou, Peoples R China.
   [Yang, Yuanyuan] Guangxi Univ Sci & Technol, Affiliated Hosp 1, Liuzhou, Peoples R China.
   [Yang, Yuanyuan] Guangxi Univ Sci & Technol, Affiliated Hosp 1, 124 Yuejin Rd, Liuzhou 545002, Peoples R China.
C3 Guangxi University of Science & Technology; Guangxi University of
   Science & Technology; Guangxi University of Science & Technology
RP Yang, YY (corresponding author), Guangxi Univ Sci & Technol, Affiliated Hosp 1, 124 Yuejin Rd, Liuzhou 545002, Peoples R China.
EM zengjin1688@126.com; 2691245627@qq.com
CR Andrei G, 2021, MOLECULES, V26, DOI 10.3390/molecules26041132
   Gao CR., 2013, DIAGNOSIS TREATMENT, P662
   Henze L, 2022, ANN HEMATOL, V101, P491, DOI 10.1007/s00277-021-04746-y
   Jin Jill, 2018, JAMA, V320, P416, DOI [10.1001/jama.2018.7263, 10.1001/jama.2018.7263]
   Kawai K, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-004833
   Li LM., 2020, GUID J TRADIT CHIN M, V26, P104
   Li RZ, 2021, FRONT NEUROL, V12, DOI 10.3389/fneur.2021.741054
   Nalamachu S, 2012, DRUG AGING, V29, P863, DOI 10.1007/s40266-012-0014-3
   Zhang Y., 2017, MED RECAPITULATE, V23, P4256
NR 9
TC 1
Z9 2
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY 26
PY 2023
VL 102
IS 21
DI 10.1097/MD.0000000000033766
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA H4LV3
UT WOS:000995704800027
PM 37233427
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Goel, AR
   Henderson, CR
   Reid, MC
AF Goel, Anurag Ratan
   Henderson, Charles R.
   Reid, Manney Carrington
TI Do Palliative Care Providers Use Complementary and Integrative Medicine?
   A Nationwide Survey
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Article
DE Complementary; integrative; alternative; nationwide survey; usage
   patterns; recommendation rates
ID ALTERNATIVE MEDICINE; ADVANCED CANCER; PHYSICIANS ATTITUDES; FOLLOW-UP;
   THERAPIES; PREVALENCE; KNOWLEDGE; PATTERNS; MANAGEMENT; HOSPICE
AB Context. Given the high prevalence of burdensome symptoms in palliative care (PC) and increasing use of complementary and integrative medicine (CIM) therapies, research is needed to determine how often and what types of CIM therapies providers recommend to manage symptoms in PC.
   Objectives. To document recommendation rates of CIM for target symptoms and assess if, CIM use varies by provider characteristics.
   Methods. Nationwide survey's of physicians (MD and DO), physician assistants, and nurse practitioners in PC.
   Results. Participants (N = 404) were mostly female (71.3%), physicians (74.9%), and cared for adults (90.4%). Providers recommended CIM an average of 6.82 times per-month (95% CI: 6.04-7.60) and used an average of 5.13 (95% CI: 4.90-5.36) out of 10 CIM modalities. Respondents recommended mind-body medicines (e.g., meditation, biofeedback) most, followed by massage, and acupuncture and/or acupressure. The most targeted symptoms included pain; followed by anxiety, mood disturbance, and distress. Recommendation frequencies for specificmodality-for-symptomcombinations ranged fromlittle use (e.g., aromatherapy for constipation) to occasional use (e.g., mind-body interventions for psychiatric symptoms). Finally, recommendation rates increased as a function of pediatric practice, noninpatient practice setting, provider age, and proportion of effort spent delivering palliative care.
   Conclusion. To the best of our knowledge, this is the first national survey to characterize PC providers' CIM recommendation behaviors and assess specific therapies and common target symptoms. Providers recommended a broad range of CIM but do so less frequently than patients report using CIM. These findings should be of interest to any provider caring for patients with serious illness. (C) 2021 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Goel, Anurag Ratan] Brown Univ, Dept Med, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Goel, Anurag Ratan] Brown Univ, Dept Pediat, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Henderson, Charles R.] Cornell Univ, Dept Human Dev, Ithaca, NY USA.
   [Reid, Manney Carrington] Weill Cornell Med, Dept Med, New York, NY USA.
C3 Brown University; Brown University; Cornell University; Cornell
   University; Weill Cornell Medicine
RP Reid, MC (corresponding author), Weill Cornell Med, Div Geriatr & Palliat Med, 525 East 68th St Box 39, New York, NY 10065 USA.
EM mcr2004@med.cornell.edu
OI Reid, Cary/0000-0001-8117-662X
FU National Institute on Aging [K24AGO53462, P30AG022845]; National
   Institute on Aging [K24AG053462, P30AG022845, T32AG049666] Funding
   Source: NIH RePORTER
FX MCR is supported by grants from the National Institute on Aging
   [K24AGO53462, P30AG022845].
CR [Anonymous], HLTH TOP A Z
   [Anonymous], 1992, International statistical classification of diseases and related health problems
   [Anonymous], 2013, NHPCOs facts and figures: Hospice care in America
   Astin JA, 1998, JAMA-J AM MED ASSOC, V279, P1548, DOI 10.1001/jama.279.19.1548
   Axtner J, 2016, BMC CANCER, V16, DOI 10.1186/s12885-016-2594-5
   Barnes Patricia M, 2008, Natl Health Stat Report, P1
   Bercovitz Anita, 2011, Natl Health Stat Report, P1
   Berman B M, 1998, J Am Board Fam Pract, V11, P272
   Berman BM, 2002, ARCH INTERN MED, V162, P766, DOI 10.1001/archinte.162.7.766
   Bishop FL, 2010, PEDIATRICS, V125, P768, DOI 10.1542/peds.2009-1775
   Blinderman CD, 2015, NEW ENGL J MED, V373, P2549, DOI 10.1056/NEJMra1411746
   Bookbinder M, 2010, NURS CLIN N AM, V45, P271, DOI 10.1016/j.cnur.2010.04.002
   Center for Advancing Palliative Care, AM CAR SER ILLN 2019
   Chan Pon-Sang, 2004, Hawaii Med J, V63, P176
   Chiaramonte DR, 2020, J ALTERN COMPLEM MED, V26, P761, DOI 10.1089/acm.2020.0366
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   Corbin LW, 2009, J PALLIAT MED, V12, P7, DOI 10.1089/jpm.2008.0198
   Cramer H, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010802.pub2
   Demmer Craig, 2004, J Palliat Med, V7, P510, DOI 10.1089/1096621041838335
   Eisenberg DM, 1998, JAMA-J AM MED ASSOC, V280, P1569, DOI 10.1001/jama.280.18.1569
   Esplen MJ, 2020, SUPPORT CARE CANCER, V28, P381, DOI 10.1007/s00520-019-04812-2
   Frass M, 2012, OCHSNER J, V12, P45
   Gabbard J, 2019, AM J HOSP PALLIAT ME, V36, P273, DOI 10.1177/1049909118806664
   Glare P, 2011, CLIN INTERV AGING, V6, P243, DOI 10.2147/CIA.S13109
   Goel AR, 2022, AM J HOSP PALLIAT ME, V39, P370, DOI 10.1177/10499091211011708
   Goyal M, 2014, JAMA INTERN MED, V174, P357, DOI 10.1001/jamainternmed.2013.13018
   Greene Barry R, 2006, BMC Complement Altern Med, V6, P5, DOI 10.1186/1472-6882-6-5
   Horneber M, 2012, INTEGR CANCER THER, V11, P187, DOI 10.1177/1534735411423920
   IQVIA, About us
   Kemper KJ, 2004, AMBUL PEDIATR, V4, P482, DOI 10.1367/A04-050R.1
   Kent JB, 2020, ALTERN THER HEALTH M, V26, P28
   Klein E, 2017, ARCH GYNECOL OBSTET, V296, P295, DOI 10.1007/s00404-017-4420-y
   Korak LE, 2008, AM J HOSP PALLIAT ME, V25, P463, DOI 10.1177/1049909108322292
   Kundu A, 2011, CLIN PEDIATR, V50, P153, DOI 10.1177/0009922810384724
   Kurtz Margot E., 2003, Journal of the American Osteopathic Association, V103, P597
   Lee RT, 2014, J CLIN ONCOL, V32, P4095, DOI 10.1200/JCO.2014.55.8676
   Lin YC, 2017, ANESTH ANALG, V125, P2081, DOI 10.1213/ANE.0000000000002579
   Linde K, 2015, ANN FAM MED, V13, P69, DOI 10.1370/afm.1687
   Manek NJ, 2010, BMC COMPLEM ALTERN M, V10, DOI 10.1186/1472-6882-10-5
   Maratos AS, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004517.pub2
   Mbizo J, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2342-2
   Mercadante S, 2017, SUPPORT CARE CANCER, V25, P1301, DOI 10.1007/s00520-016-3524-4
   Mitchell AJ, 2011, LANCET ONCOL, V12, P160, DOI 10.1016/S1470-2045(11)70002-X
   Moens K, 2014, J PAIN SYMPTOM MANAG, V48, P660, DOI 10.1016/j.jpainsymman.2013.11.009
   Muecke R, 2016, INTEGR CANCER THER, V15, P10, DOI 10.1177/1534735415596423
   Nahin Richard L, 2016, Natl Health Stat Report, P1
   Olotu BS, 2014, AM J HOSP PALLIAT ME, V31, P254, DOI 10.1177/1049909113486535
   Penney LS, 2017, BMC FAM PRACT, V17, DOI 10.1186/s12875-016-0566-0
   Rhode JM, 2008, INT J GYNECOL OBSTET, V103, P111, DOI 10.1016/j.ijgo.2008.06.001
   Risberg T, 2004, EUR J CANCER, V40, P529, DOI 10.1016/j.ejca.2003.11.011
   Sarris J, 2011, EUR NEUROPSYCHOPHARM, V21, P841, DOI 10.1016/j.euroneuro.2011.04.002
   SAS Institute Inc, 2013, 9.4 statements: reference
   Sawni Anju, 2007, BMC Complement Altern Med, V7, P18, DOI 10.1186/1472-6882-7-18
   Sierpina V, 2007, EXPLORE-NY, V3, P129, DOI 10.1016/j.explore.2006.12.001
   Smith CA, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004046.pub4
   Stussman BJ, 2020, J ALTERN COMPLEM MED, V26, P25, DOI 10.1089/acm.2019.0303
   Thorne S, 2002, INT J NURS STUD, V39, P671, DOI 10.1016/S0020-7489(02)00005-6
   Tomlinson D, 2011, SUPPORT CARE CANCER, V19, P1857, DOI 10.1007/s00520-010-1029-0
   Valderas JM, 2009, BMC HEALTH SERV RES, V9, DOI 10.1186/1472-6963-9-221
   Van Hyfte GJ, 2014, AM J HOSP PALLIAT ME, V31, P553, DOI 10.1177/1049909113500378
   Wahner-Roedler DL, 2014, COMPLEMENT THER CLIN, V20, P54, DOI 10.1016/j.ctcp.2013.09.003
   Weisel KK, 2019, NPJ DIGIT MED, V2, DOI 10.1038/s41746-019-0188-8
NR 62
TC 7
Z9 8
U1 0
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD APR
PY 2022
VL 63
IS 4
BP 599
EP 609
DI 10.1016/j.jpainsymman.2021.11.002
EA MAR 2022
PG 11
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA 2P7TK
UT WOS:000819938200028
PM 34788656
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Li, WJ
   Gao, C
   An, LX
   Ji, YW
   Xue, FS
   Du, Y
AF Li, Wen-jing
   Gao, Chao
   An, Li-xin
   Ji, Yu-wei
   Xue, Fu-shan
   Du, Yi
TI Perioperative transcutaneous electrical acupoint stimulation for
   improving postoperative gastrointestinal function: A randomized
   controlled trial
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Article
DE Transcutaneous electrical acupoint stimulation; Postoperative period;
   Gastrointestinal disorders; Substance P
ID COLORECTAL-CANCER RESECTION; RECOVERY; ILEUS; ACUPUNCTURE; RESPONSES;
   RISK; PAIN
AB Background: Postoperative gastrointestinal dysfunction (PGD) is one of the most common complications in patients undergoing major abdominal surgery. Acupuncture has been used widely in gastrointestinal diseases due to its effectiveness and minimally invasive nature. Objective: This study evaluated the efficacy of using transcutaneous electrical acupoint stimulation (TEAS) during the surgery and postoperative recovery in patients with gastric and colorectal surgery for improving postoperative gastrointestinal function. Design, setting, participants and interventions: A total of 280 patients undergoing abdominal surgery were stratified by type of surgery (i.e., gastric or colorectal surgery) and randomly allocated into the TEAS group (group T) or the sham group (group S). Patients in group T received TEAS at LI4, PC6, ST36 and ST37. Patients in group S received pseudo-TEAS at sham acupoints. The stimulation was given from 30 min before anesthesia until the end of surgery. The same treatment was performed at 9 am on the 1st, 2nd and 3rd days after surgery, until the recovery of flatus in patients. Main outcome measures: The primary outcome was the time to the first bowel motion, as detected by auscultation. The secondary outcomes included the first flatus and ambulation time, changes of perioperative substance P (SP), incidence of PGD, postoperative pain, postoperative nausea and vomiting (PONV) and some economic indicators. Results: The time to first bowel motion, first flatus and first ambulation in group T was much shorter than that in group S (P < 0.01). In patients undergoing colorectal surgery, the concentration of SP was lower in group T than in group S on the third day after the operation (P < 0.05). The average incidence of PGD in all patients was 25%, and the frequency of PGD was significantly lower in group T than in group S (18.6% vs. 31.4%, respectively; P < 0.05). TEAS treatment (odds ratio = 0.498; 95% confidence interval: 0.232-0.786) and type of surgery were relevant factors for the development of PGD. Postoperative pain score and PONV occurrence were significantly lower in group T (P < 0.01). Postoperative hospitalization days and the resulting cost to patients were greatly reduced in the TEAS group (P < 0.01). Conclusion: Perioperative TEAS was able to promote the recovery of postoperative gastrointestinal function, reduce the incidence of PGD and PONV. The concentration of SP was decreased by TEAS treatment, which indicates that the brain-gut axis may play a role in how TEAS regulates gastrointestinal function. Trial registration: Chinese Clinical Trial Registry, ChiCTR1900023263. Please cite this article as: Li WJ, Gao C, An LX, Ji YW, Xue FS, Du Y. Perioperative transcutaneous electrical acupoint stimulation for improving postoperative gastrointestinal function: A randomized controlled trial. J Integr Med. Perioperative transcutaneous electrical acupoint stimulation for improving postoperative gastrointestinal function: A randomized controlled trial. J Integr Med. 2021; 19(3): 211-218. (C) 2021 Shanghai Changhai Hospital. Published by ELSEVIER B.V. All rights reserved.
C1 [Li, Wen-jing; An, Li-xin; Ji, Yu-wei; Xue, Fu-shan] Capital Med Univ, Beijing Friendship Hosp, Dept Anesthesiol, Beijing 100050, Peoples R China.
   [Gao, Chao] Beijing Hui Min Hosp, Dept Anesthesiol, Beijing 100053, Peoples R China.
   [Du, Yi] Capital Med Univ, Beijing Friendship Hosp, Dept Tradit Chinese Med, Beijing 100050, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP An, LX (corresponding author), Capital Med Univ, Beijing Friendship Hosp, Dept Anesthesiol, Beijing 100050, Peoples R China.
EM anlixin8120@163.com
RI ; Xue, Fu-Shan/ADO-0664-2022
OI 高, 超/0009-0005-8721-0944; 
FU Beijing Administration of Traditional Chinese Medicine, PR China
   [JJ-2020-62]
FX This study was supported by the Beijing Administration of Traditional
   Chinese Medicine, PR China (Grant No. JJ-2020-62). The funding agent
   plays no role in study design, data collection, data analysis, data
   interpretation, writing of the report, or submission of the report as an
   article for publication.
CR An LX, 2014, AM J CHINESE MED, V42, P1099, DOI 10.1142/S0192415X14500682
   Bai YF, 2020, TRIALS, V21, DOI 10.1186/s13063-020-04470-4
   Bragg D, 2015, CLIN NUTR, V34, P367, DOI 10.1016/j.clnu.2015.01.016
   Chen JB, 2020, INT J SURG, V73, P57, DOI 10.1016/j.ijsu.2019.10.036
   Chen YZ, 2020, J GASTROEN HEPATOL, V35, P1549, DOI 10.1111/jgh.15020
   Cheng H, 2011, CHINESE MED J-PEKING, V124, P1229, DOI 10.3760/cma.j.issn.0366-6999.2011.08.020
   Chi YL, 2019, AM J CHINESE MED, V47, P1445, DOI 10.1142/S0192415X19500745
   Fu CW, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000020301
   Hedrick TL, 2018, ANESTH ANALG, V126, P1896, DOI 10.1213/ANE.0000000000002742
   Hou LL, 2016, J TRADIT CHIN MED, V36, P450
   Huang W, 2019, J TRADIT CHIN MED, V39, P433
   Liu LS, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019610
   Liu YH, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/3178472
   Martin CR, 2018, CELL MOL GASTROENTER, V6, P133, DOI 10.1016/j.jcmgh.2018.04.003
   Murphy MM, 2016, J SURG RES, V201, P279, DOI 10.1016/j.jss.2015.10.047
   Paulasir S, 2015, DIS COLON RECTUM, V58, P870, DOI 10.1097/DCR.0000000000000430
   Qu Li Zhe, 2020, Zhen Ci Yan Jiu, V45, P136, DOI 10.13702/j.1000-0607.1904016
   Shin KM, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/918392
   Steinhoff MS, 2014, PHYSIOL REV, V94, P265, DOI 10.1152/physrev.00031.2013
   Venara A, 2016, J VISC SURG, V153, P439, DOI 10.1016/j.jviscsurg.2016.08.010
   Wang HY, 2018, AM J CHINESE MED, V46, P1387, DOI 10.1142/S0192415X18500738
   Xue ZZ, 2019, LIFE SCI, V233, DOI 10.1016/j.lfs.2019.116749
   Yang FM, 2020, CHIN J INTEGR MED, V26, P310, DOI 10.1007/s11655-019-3150-3
   Yang Y, 2017, SCI REP-UK, V7, DOI 10.1038/srep37826
   Yu YC, 2019, FRONT CELL NEUROSCI, V13, DOI 10.3389/fncel.2019.00030
   Yuan HC, 2020, CHIN J INTEGR MED, V26, P769, DOI 10.1007/s11655-019-3048-0
NR 26
TC 58
Z9 69
U1 13
U2 72
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD MAY
PY 2021
VL 19
IS 3
BP 211
EP 218
DI 10.1016/j.joim.2021.01.005
EA MAY 2021
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA RZ5ZR
UT WOS:000648676000003
PM 33495134
DA 2026-01-16
ER

PT J
AU Kim, WK
   Shin, JS
   Lee, J
   Koh, W
   Ha, IH
   Park, HJ
   Lee, SK
   Hong, JY
AF Kim, Won Kyung
   Shin, Joon-Shik
   Lee, Jinho
   Koh, Wonil
   Ha, In-Hyuk
   Park, Hyen Joo
   Lee, Sang Kook
   Hong, Jin Young
TI Effects of the administration of Shinbaro 2 in a rat lumbar disk
   herniation model
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE lumbar disc herniation; Shinbaro 2; pro-inflammatory cytokines;
   inflammation; disk degeneration-related factors
ID INTERVERTEBRAL DISC; PAIN; CENTIPEDE; GCSB-5
AB The current standard for the pharmacological management of lumbar disk herniation (LDH), involving non-steroidal anti-inflammatory drugs, muscle relaxants, and opioid analgesics, often carries a risk of adverse events. The search for alternative therapeutic options remains a vital objective, given the high prevalence of LDH and the critical impact on the quality of life. Shinbaro 2 is a clinically effective herbal acupuncture against inflammation and various musculoskeletal disorders. Therefore, we explored whether Shinbaro 2 exerts protective effects in an LDH rat model. The results showed that Shinbaro 2 suppressed pro-inflammatory cytokines, interleukin-1 beta, tumor necrosis factor-alpha, disk degeneration-related factors, matrix metalloproteinase-1,-3,-9, and ADAMTS-5 in LDH rats. Shinbaro 2 administration reinstated a behavioral activity to a normal level in the windmill test. The results indicated that Shinbaro 2 administration restored spinal cord morphology and functions in the LDH model. Therefore, Shinbaro 2 exerted a protective effect in LDH via actions on inflammatory responses and disk degeneration, indicating that future research is warranted to assess the action mechanisms further and validate its effects.
C1 [Kim, Won Kyung; Park, Hyen Joo; Lee, Sang Kook] Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul, South Korea.
   [Shin, Joon-Shik; Lee, Jinho; Koh, Wonil] Jaseng Hosp Korean Med, Seoul, South Korea.
   [Ha, In-Hyuk; Hong, Jin Young] Jaseng Med Fdn, Jaseng Spine & Joint Res Inst, Seoul, South Korea.
C3 Seoul National University (SNU)
RP Lee, SK (corresponding author), Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul, South Korea.; Hong, JY (corresponding author), Jaseng Med Fdn, Jaseng Spine & Joint Res Inst, Seoul, South Korea.
EM sklee61@snu.ac.kr; vrt23@jaseng.org
CR Ali SM, 2019, AMB EXPRESS, V9, DOI 10.1186/s13568-019-0816-3
   Alini M, 2008, EUR SPINE J, V17, P2, DOI 10.1007/s00586-007-0414-y
   Amin RM, 2017, CURR REV MUSCULOSKE, V10, P507, DOI 10.1007/s12178-017-9441-4
   Bachmeier BE, 2009, EUR SPINE J, V18, P1573, DOI 10.1007/s00586-009-1031-8
   Chao WW, 2011, CHIN MED-UK, V6, DOI 10.1186/1749-8546-6-29
   Cho G, 2015, J PHARMACOPUNCT, V18, P44, DOI 10.3831/KPI.2015.18.005
   Cho HK, 2016, J KOREAN NEUROSURG S, V59, P98, DOI 10.3340/jkns.2016.59.2.98
   Choi HS, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/2345640
   Cunha C, 2018, ARTHRITIS RES THER, V20, DOI 10.1186/s13075-018-1743-4
   Daly C, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/5952165
   Ducati LG, 2013, EUR SPINE J, V22, pS404, DOI 10.1007/s00586-012-2516-4
   Freynhagen R, 2009, CURR PAIN HEADACHE R, V13, P185, DOI 10.1007/s11916-009-0032-y
   Gao WD, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/1860637
   García-Cosamalón J, 2010, J ANAT, V217, P1, DOI 10.1111/j.1469-7580.2010.01227.x
   He JB, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01344
   HOLM S, 1993, ACTA ORTHOP SCAND, V64, P13, DOI 10.3109/17453679309160105
   Nasab NH, 2021, NAT PROD COMMUN, V16, DOI 10.1177/1934578X211050790
   Hwang L, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/5057372
   Ito T, 2007, SPINE, V32, P159, DOI 10.1097/01.brs.0000251437.10545.e9
   Jung HW, 2010, INT IMMUNOPHARMACOL, V10, P155, DOI 10.1016/j.intimp.2009.10.010
   Kanemoto M, 1996, SPINE, V21, P1, DOI 10.1097/00007632-199601010-00001
   Kang JD, 1997, SPINE, V22, P1065, DOI 10.1097/00007632-199705150-00003
   Karbwang J, 1997, EUR J CLIN PHARMACOL, V52, P307, DOI 10.1007/s002280050295
   Kim MJ, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/6749425
   Kim TH, 2011, J ETHNOPHARMACOL, V136, P297, DOI 10.1016/j.jep.2011.04.037
   Kim WK, 2016, CHIN MED-UK, V11, DOI 10.1186/s13020-016-0089-6
   Lee H, 2017, BIOCHEM J, V474, P635, DOI [10.1042/BCJ20161039, 10.1042/bcj20161039]
   Lee SG, 2012, J ETHNOPHARMACOL, V142, P634, DOI 10.1016/j.jep.2012.05.020
   Lee YJ, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1942-6
   Lee YJ, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1288-5
   Löffek S, 2011, EUR RESPIR J, V38, P191, DOI 10.1183/09031936.00146510
   Lu PF, 2011, CSH PERSPECT BIOL, V3, DOI 10.1101/cshperspect.a005058
   Oliveira CB, 2018, EUR SPINE J, V27, P2791, DOI 10.1007/s00586-018-5673-2
   Park JH, 2021, J CLIN MED, V10, DOI 10.3390/jcm10081703
   Park SH, 2019, MEDIAT INFLAMM, V2019, DOI 10.1155/2019/7651470
   Risbud MV, 2014, NAT REV RHEUMATOL, V10, P44, DOI 10.1038/nrrheum.2013.160
   Ruan WF, 2016, INT J SURG, V31, P86, DOI 10.1016/j.ijsu.2016.05.061
   Taher F, 2012, ADV ORTHOP, V2012, DOI 10.1155/2012/970752
   Zhang XX, 2022, FRONT PLANT SCI, V13, DOI 10.3389/fpls.2022.980854
   Zhao DD, 2016, MOLECULES, V21, DOI 10.3390/molecules21101362
NR 40
TC 8
Z9 12
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD MAR 10
PY 2023
VL 14
AR 1044724
DI 10.3389/fneur.2023.1044724
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 0A4SA
UT WOS:000951812800001
PM 36970511
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Shi, J
   Ge, ZBZ
   Jin, Y
   Li, YD
   Zhou, J
AF Shi, J.
   Ge, Z. B. Z.
   Jin, Y.
   Li, Y. D.
   Zhou, J.
TI ACUPUNCTURE IMPROVES THE EFFECTS OF CHINESE HERBAL MEDICINE IN TREATING
   ENDOMETRIOSIS MODEL RATS
SO JOURNAL OF ANIMAL AND PLANT SCIENCES
LA English
DT Article
DE Chinese herbal medicine acupuncture; endometriosis
ID SERUM CA-125 LEVELS; EUTOPIC ENDOMETRIUM; PELVIC PAIN; WOMEN;
   CYCLOOXYGENASE-2; EPIDEMIOLOGY; EXPRESSION; INTERLEUKIN-18; PREVALENCE;
   INFERTILE
AB The present study was aimed to investigate whether acupuncture could significantly enhance the efficacy of Chinese herbal medicine (CHM) in treating endometriosis model rats. A total of 40 female Sprague-Dawley (SD) rats with body weight of 200 +/- 20 g were included. Operational transplantation was used with animal models. The rats were randomly divided into 5 groups: sham-operation control group (Group A), model group (Group B), CHM combined with acupuncture group (Group C), CHM group (Group D), Danazol group (Group E) with 8 rats in each group. During the treatment, two rats in Group B and one rat in Group E passed away. When the treatment ended, all the left rats were sacrificed. The samples of peritoneal fluids, serum and the ectopic endometrium were taken. The serum levels of cancer antigen 125 (CA-125) and interleukin 18(IL-18) in the peritoneal fluids were detected using enzyme-linked immune-sorbent assay. The cyclooxygenase-2 (COX-2) mRNA expression levels in the ectopic endometrium were measured by Real-time PCR. The results showed that in the rats from Groups A, C, D and E, the serum CA-125 levels, COX-2 mRNA expression in the ectopic endometrium and the IL-18 levels in the peritoneal fluids were significantly lower than those of Group B (P<0.05). The serum CA-125 levels and COX-2 mRNA expression in the ectopic endometrium of the rats in Group C were significantly lower than those of Group D (P<0.05), while there was no significant difference between Group C and E (P>0.05). The levels of IL-18 in the peritoneal fluids of the rats in Group C were markedly lower than those of Group D and E (P<0.05). It is then concluded that acupuncture treatment can improve the effects of CHM in treating endometriosis model rats.
C1 [Shi, J.; Jin, Y.; Li, Y. D.] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China.
   [Ge, Z. B. Z.] Zhejiang Univ, Sir Run Shaw Hosp, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China.
   [Zhou, J.] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310012, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang Gongshang University
RP Zhou, J (corresponding author), Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310012, Zhejiang, Peoples R China.
EM juezhou2006@yahoo.com.cn
FU Zhejiang Administration of Traditional Chinese Medicine [2011ZA048,
   2008YA023]; Health Department of Zhejiang Province [2011KYA053];
   Zhejiang Provincial Education Department [Y201016894]; Science and
   Technology foundation of Overseas Scientists of Zhejiang Province
   [2011443]; Zhejiang Gongshang University [QY11-20]
FX The present research was funded by Zhejiang Administration of
   Traditional Chinese Medicine (No. 2011ZA048 and partly by 2008YA023);
   Health Department of Zhejiang Province (No. 2011KYA053) and Zhejiang
   Provincial Education Department (No. Y201016894). Dr Jue Zhou is funded
   by Science and Technology foundation of Overseas Scientists of Zhejiang
   Province (No. 2011443); Young Scientist Grant of Zhejiang Gongshang
   University (No. QY11-20).
CR Arici A, 2003, FERTIL STERIL, V80, P889, DOI 10.1016/S0015-0282(03)01122-1
   Ayaz L, 2011, FERTIL STERIL, V95, P298, DOI 10.1016/j.fertnstert.2010.07.1046
   Barbieri R L, 1987, Contrib Gynecol Obstet, V16, P103
   Brown J, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008475.pub2
   Chen FP, 1998, ACTA OBSTET GYN SCAN, V77, P665, DOI 10.1034/j.1600-0412.1998.770615.x
   Chen Ming, 2010, Zhongguo Zhen Jiu, V30, P725
   Chishima F, 2002, AM J REPROD IMMUNOL, V48, P50, DOI 10.1034/j.1600-0897.2002.01101.x
   Cho S, 2010, GYNECOL OBSTET INVES, V69, P93, DOI 10.1159/000261017
   Davis L, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001019.pub2
   Ramos IMD, 2012, REV ASSOC MED BRAS, V58, P26
   Ferrero S, 2010, EXPERT OPIN PHARMACO, V11, P1123, DOI 10.1517/14656561003685880
   Flower A, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006568.pub2
   Flower A, 2011, J ALTERN COMPLEM MED, V17, P691, DOI 10.1089/acm.2010.0073
   Giudice LC, 2004, LANCET, V364, P1789, DOI 10.1016/S0140-6736(04)17403-5
   GUILLEBAUD J, 1993, BRIT MED J, V306, P931, DOI 10.1136/bmj.306.6882.931
   Guo SW, 2006, GYNECOL OBSTET INVES, V62, P121, DOI 10.1159/000093019
   Guo SW, 2006, FERTIL STERIL, V86, P1584, DOI 10.1016/j.fertnstert.2006.04.040
   Lundeberg T, 2008, ACUPUNCT MED, V26, P94, DOI 10.1136/aim.26.2.94
   Machado DE, 2010, FERTIL STERIL, V93, P2674, DOI 10.1016/j.fertnstert.2009.11.037
   Matalliotakis IM, 2004, INT J FERTIL WOMEN M, V49, P75
   Matsuzaki S, 2004, FERTIL STERIL, V82, P1309, DOI 10.1016/j.fertnstert.2004.03.059
   Meissner K, 2010, FORSCH KOMPLEMENTMED, V17, P314, DOI 10.1159/000322890
   Ota H, 2001, HUM REPROD, V16, P561, DOI 10.1093/humrep/16.3.561
   OZAKSIT G, 1995, INT J GYNECOL OBSTET, V50, P269, DOI 10.1016/0020-7292(95)02456-M
   PARAZZINI F, 1993, BRIT MED J, V306, P930, DOI 10.1136/bmj.306.6882.930-b
   PATTON PE, 1986, FERTIL STERIL, V45, P770
   PITTAWAY DE, 1995, FERTIL STERIL, V64, P321, DOI 10.1016/S0015-0282(16)57730-9
   PRENTICE A, 1993, BRIT MED J, V306, P585, DOI 10.1136/bmj.306.6877.585-d
   PRENTICE A, 2000, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD002122
   Sagsveen M., 2003, COCHRANE DB SYST REV
   Schnyer RN, 2008, J ALTERN COMPLEM MED, V14, P515, DOI 10.1089/acm.2007.0826
   SELAK V, 2001, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD000068.PUB2
   Sharpe-Timms KL, 2004, FERTIL STERIL, V81, P1201, DOI 10.1016/j.fertnstert.2003.09.072
   Simoens S, 2007, HUM REPROD UPDATE, V13, P395, DOI 10.1093/humupd/dmm010
   Sinaii N, 2007, FERTIL STERIL, V87, P1277, DOI 10.1016/j.fertnstert.2006.11.051
   VESSEY MP, 1993, BRIT MED J, V306, P182, DOI 10.1136/bmj.306.6871.182
   Viganò P, 2004, BEST PRACT RES CL OB, V18, P177, DOI 10.1016/j.bpobgyn.2004.01.007
   Wang D Z, 1994, Zhongguo Zhong Xi Yi Jie He Za Zhi, V14, P112
   Wieser F, 2009, BIOL REPROD, V81, P371, DOI 10.1095/biolreprod.108.075069
   Xiang Dong-Fang, 2011, Zhongguo Zhen Jiu, V31, P113
   Zhang Yi, 2005, Zhong Nan Da Xue Xue Bao Yi Xue Ban, V30, P731
   Zhu X., 2011, COCHRANE DB SYST REV, V9
NR 42
TC 2
Z9 2
U1 0
U2 11
PU PAKISTAN AGRICULTURAL SCIENTISTS FORUM
PI LAHORE
PA UNIV VETERINARY & ANIMAL SCIENCES, LAHORE, 00000, PAKISTAN
SN 1018-7081
J9 J ANIM PLANT SCI
JI J. Anim. Plant Sci.
PY 2013
VL 23
IS 1
BP 298
EP 303
PG 6
WC Agriculture, Multidisciplinary; Biology; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Life Sciences & Biomedicine - Other Topics; Veterinary
   Sciences
GA 102NB
UT WOS:000315850200045
DA 2026-01-16
ER

PT J
AU Wong, R
   Major, P
   Sagar, S
AF Wong, Raimond
   Major, Pierre
   Sagar, Stephen
TI Phase 2 Study of Acupuncture-Like Transcutaneous Nerve Stimulation for
   Chemotherapy-Induced Peripheral Neuropathy
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE chemotherapy; ALTENS; Acupuncture; TENS; neuropathy
ID PILOCARPINE
AB A prospective phase 2 study was conducted to evaluate the clinical utility of acupuncture-like transcutaneous nerve stimulation (ALTENS) for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). Eligible cancer patients had a < 2 ECOG performance score, received neurotoxic chemotherapy, and developed CIPN symptoms for > two months. Randomization was used to eliminate bias in patient selection for ALTENS and was not to compare the effectiveness between the two treatments.ALTENS treatments were delivered using Codetron units. Bilateral acupuncture points included LI4 and LIV3, plus LI11 or ST36 were stimulated. Acupuncture treatments were administered to CV6, SP6, ST6, LI11, Bafeng, Baxie and selective Jing points bilaterally. Twelve treatments were delivered twice weekly over 6 to 8 weeks. The Modified Total Neuropathy Score (mTNS), Numbness Score, and Edmonton Symptom Assessment Score (ESAS) were assessed at baseline, treatment completion, plus at 3 and 6 months follow-up. The primary study endpoint was mTNS score at 6 months. We planned to recruit 23 patients into each group. After 30 patients were recruited, 2 were lost to follow-up at 3 months in the ALTENS group and 3 in the acupuncture group. The research team decided to recruit all remaining consecutive patients only to the ALTENS group to ensure an adequate evaluation of ALTENS, the primary object of evaluation. There were 27 patients in the ALTENS group, with an average symptom duration of 10 months after chemotherapy. Twenty four and 23 patients completed the 3 and 6 month follow-up respectively. The median mTNS scores were 7.1, 4.0, 3.6 and 3.1 at baseline, treatment completion, 3 and 6 months follow-up, respectively. One-way ANOVA analysis showed a significant improvement in mTNS scores (p<0.001) at 6 months. Numbness scores were also significantly improved at 6 months. ESAS pain scores and perception of well-being scores analyses were inconclusive. There were no significant reported side effects of ALTENS. There were only 13 patients in the acupuncture group and the number was insufficient for either an independent or a comparative analysis. The results of this study suggests that ALTENS significantly reduces the mTNS scores and numbness in patients suffering from CIPN symptoms.
C1 [Wong, Raimond; Major, Pierre; Sagar, Stephen] McMaster Univ, Juravinski Canc Ctr, Hamilton, ON, Canada.
C3 McMaster University
RP Wong, R (corresponding author), Juravinski Canc Ctr, Dept Radiat Oncol, 699 Concess St, Hamilton, ON L8V 5C2, Canada.
EM wongrai@hhsc.ca
OI Sagar, Stephen/0009-0002-9013-1989
FU Lotte & John Hecht Memorial Foundation, Vancouver, Canada
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The study
   was funded by the Lotte & John Hecht Memorial Foundation, Vancouver,
   Canada.
CR Avan A, 2015, ONCOLOGIST, V20, P411, DOI 10.1634/theoncologist.2014-0044
   Bhagra Anjali, 2007, Curr Oncol Rep, V9, P290
   Bruera E, 1991, J Palliat Care, V7, P6
   FARGASBABJAK AM, 1992, ACUPUNCTURE ELECTRO, V17, P95, DOI 10.3727/036012992816357828
   FOX EJ, 1976, PAIN, V2, P141, DOI 10.1016/0304-3959(76)90109-3
   Franconi G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/516916
   Guyton A.C., 1976, STRUCTURE FUNCTION N
   Kamei N, 2005, J DIABETES COMPLICAT, V19, P47, DOI 10.1016/j.jdiacomp.2003.12.006
   Kim JH, 2015, GYNECOL ONCOL, V136, P453, DOI 10.1016/j.ygyno.2015.01.524
   LAITINEN J, 1976, American Journal of Chinese Medicine, V4, P169, DOI 10.1142/S0192415X76000214
   Pomeranz B., 1987, AM J ELECTROMED, V2, P22
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Walters S., 2009, QUALITY LIFE OUTCOME
   Wampler MA, 2006, J SUPPORT ONCOL, V4, P9
   Watson T, 2010, PHYS THER REV, V15, P351, DOI 10.1179/1743288X10Y.0000000009
   Wong RKW, 2015, INT J RADIAT ONCOL, V92, P220, DOI 10.1016/j.ijrobp.2015.01.050
   Wong RKW, 2012, CANCER-AM CANCER SOC, V118, P4244, DOI 10.1002/cncr.27382
NR 17
TC 28
Z9 30
U1 1
U2 24
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD JUN
PY 2016
VL 15
IS 2
BP 153
EP 164
DI 10.1177/1534735415627926
PG 12
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA DM4HC
UT WOS:000376306900003
PM 27130723
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Liu, JP
   Han, M
   Li, XX
   Mu, YJ
   Lewith, G
   Wang, YY
   Witt, CM
   Yang, GY
   Manheimer, E
   Snellingen, T
   Berman, B
   Gluud, C
AF Liu, Jian-Ping
   Han, Mei
   Li, Xin-Xue
   Mu, Yu-Jie
   Lewith, George
   Wang, Yu-Yi
   Witt, Claudia M.
   Yang, Guo-Yan
   Manheimer, Eric
   Snellingen, Torkel
   Berman, Brian
   Gluud, Christian
TI Prospective registration, bias risk and outcome-reporting bias in
   randomised clinical trials of traditional Chinese medicine: an empirical
   methodological study
SO BMJ OPEN
LA English
DT Article
ID QUALITY
AB Background Clinical trials on Traditional Chinese Medicine (TCM) should be registered in a publicly accessible international trial register and report on all outcomes. We systematically assessed and evaluated TCM trials in registries with their subsequent publications.
   Objective To describe the characteristics of TCM trials, estimate bias risk and outcome-reporting bias in clinical trials.
   Data sources and study selection Fifteen trial registries were searched from their inception to July 2012 to identify randomised trials on TCM including Chinese herbs, acupuncture and/or moxibustion, cupping, tuina, qigong, etc.
   Data extraction We extracted data including TCM specialty and treated disease/conditions from the registries and searched for subsequent publications in PubMed and Chinese databases. We compared information in the registries of completed trials with any publications focusing on study design, sample size, randomisation, bias risk including reporting bias from the register protocol.
   Results 1096 registered randomised trials were identified evaluating TCM, of which 505 were completed studies (46.1%). The most frequent conditions were pain (13.3%), musculoskeletal (11.7%), nervous (8.7%), digestive (7.1%), circulatory (6.5%), respiratory (6.3%), mental and behavioural disorders (6.2%) and cancer (6.0%). The trial register data identified parallel, phase II/III randomised trials with sample size estimations and blinding, but limited information about randomisation (sequence generation and allocation concealment). Comparing trial registration data of 115 completed trials (22.8%) with their subsequent 136 publications, inconsistencies were identified in one or more of the following: sample size (11%), outcome assessor blinding (37.5%), primary outcomes (29%) and safety (28%) reporting.
   Conclusions Increasing numbers of clinical trials investigating a variety of TCM interventions have been registered in international trial registries. The study design of registered TCM trials has improved in estimating sample size, use of blinding and placebos. However, selective outcome reporting is widespread and similar to conventional medicine and therefore study conclusions should be interpreted with caution.
C1 [Liu, Jian-Ping; Han, Mei; Li, Xin-Xue; Mu, Yu-Jie; Wang, Yu-Yi; Yang, Guo-Yan; Snellingen, Torkel] Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing, Peoples R China.
   [Lewith, George] Univ Southampton, Ctr Complementary Med Res, Southampton, Hants, England.
   [Witt, Claudia M.] Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany.
   [Manheimer, Eric; Berman, Brian] Univ Maryland, Sch Med, Ctr Integrat Med, Baltimore, MD 21201 USA.
   [Gluud, Christian] Copenhagen Univ Hosp, Rigshosp, Ctr Clin Intervent Res, Copenhagen Trial Unit, Copenhagen, Denmark.
C3 Beijing University of Chinese Medicine; University of Southampton; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University System of Maryland; University of
   Maryland Baltimore; Rigshospitalet; University of Copenhagen; Copenhagen
   University Hospital
RP Liu, JP (corresponding author), Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing, Peoples R China.
EM Liujp@bucm.edu.cn
RI Witt med, Claudia M/AAX-2370-2021; Yang, Guoyan/AAG-7873-2021; Gluud,
   Christian/HGB-3191-2022
OI Witt med, Claudia M/0000-0002-5440-7805; Wang, Yuyi/0000-0002-4031-0420;
   Liu, Jianping/0000-0002-0320-061X; Yang, Guoyan/0000-0002-8012-2379;
   Lewith, George/0000-0002-2364-3960; Gluud, Christian/0000-0002-8861-0799
FU NCCAM of NIH, USA; Ministry of Science and Technology, China [R24
   AT001293, 2011-CXTD-09, 2011ZX09302-006-01-03(5)]; National Center for
   Complementary and Integrative Health [R24AT001293] Funding Source: NIH
   RePORTER
FX NCCAM of NIH, USA, Ministry of Science and Technology, China (grant
   number R24 AT001293, 2011-CXTD-09, 2011ZX09302-006-01-03(5))
CR Abaid LN, 2007, OBSTET GYNECOL, V109, P1434, DOI 10.1097/01.AOG.0000266557.11064.2a
   [Anonymous], 2005, BMJ-BRIT MED J
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], INT CLIN TRIALS REG
   Chan AW, 2004, JAMA-J AM MED ASSOC, V291, P2457, DOI 10.1001/jama.291.20.2457
   Dickersin K, 2003, JAMA-J AM MED ASSOC, V290, P516, DOI 10.1001/jama.290.4.516
   He J, 2011, TRIALS, V12, DOI 10.1186/1745-6215-12-122
   Higgins JP., 2011, COCHRANE HDB SYSTEMA, DOI DOI 10.1007/S12119-019-09598-3
   Mathieu S, 2009, JAMA-J AM MED ASSOC, V302, P977, DOI 10.1001/jama.2009.1242
   Reveiz L, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012484
   Savovic J, 2012, ANN INTERN MED, V157, P429, DOI 10.7326/0003-4819-157-6-201209180-00537
   Tang JL, 1999, BMJ-BRIT MED J, V319, P160, DOI 10.1136/bmj.319.7203.160
   Vickers A, 1998, CONTROL CLIN TRIALS, V19, P159, DOI 10.1016/S0197-2456(97)00150-5
   Viergever RF, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014701
   Wang G, 2007, CLIN THER, V29, P1456, DOI 10.1016/j.clinthera.2007.07.023
   Wood L, 2008, BMJ-BRIT MED J, V336, P601, DOI 10.1136/bmj.39465.451748.AD
NR 16
TC 48
Z9 51
U1 1
U2 13
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2013
VL 3
IS 7
AR e002968
DI 10.1136/bmjopen-2013-002968
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 291CO
UT WOS:000329805500049
PM 23864210
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Akutay, S
   Kaçmaz, HY
   Ceyhan, Ö
AF Akutay, Seda
   Kacmaz, Hatice Yuceler
   Ceyhan, Ozlem
TI The healing power of transcutaneous electrical nerve stimulation: a
   systematic review on its effects after breast surgery
SO SUPPORTIVE CARE IN CANCER
LA English
DT Review
DE Breast cancer; Transcutaneous electrical nerve stimulation; Pain;
   Postoperative care
ID ACUPOINT STIMULATION; POSTOPERATIVE NAUSEA; PAIN; TENS; MECHANISMS;
   RECOVERY; QUALITY
AB BackgroundTranscutaneous electrical stimulation after breast cancer surgery has been utilized for various purposes, but the full efficacy of this treatment approach on postoperative symptoms remains unclear.AimThis study aimed to answer the question: Does transcutaneous electrical nerve stimulation significantly impact postoperative patient outcomes in individuals undergoing breast cancer surgery?MethodsA systematic review of randomized controlled trials was conducted. Because of the limited number of studies included, it was not feasible to perform a meta-analysis. English-language publications from 2013 and 2024 that investigated the effects of transcutaneous electrical stimulation in breast cancer surgery patients were included. Electronic databases such as Web of Science, PubMed, Scopus, EBSCO, ScienceDirect, Cochrane Central Register of Controlled Trials, and Wiley Online Library were searched. Two independent investigators assessed the studies using the revised JBI risk of bias tool. Data from randomized trials were extracted by two researchers using the Cochrane data collection tool.ResultsOur comprehensive literature review identified 251 studies. After rigorous assessment, 12 articles met our inclusion criteria. Title and abstract screening excluded seven studies that did not involve surgery, used treatments other than TENS, included acupuncture, or did not measure pain outcomes. Among these, five studies involving 776 patients examined the effects of transcutaneous electrical stimulation on pain management in breast cancer surgery. In all of the studies reviewed, transcutaneous electrical stimulation had a beneficial effect on postoperative pain.ConclusionTranscutaneous electrical stimulation has significantly alleviated pain associated with breast cancer surgery. This therapeutic modality has improved patient satisfaction with analgesia by relieving pain; reducing analgesic use; reducing postoperative nausea and vomiting; increasing blood levels of IL-2, IFN-gamma, and IL-2/IL-4 ratio; and reducing skin sensitivity. Transcutaneous electrical stimulation devices may improve postoperative patient outcomes and enhance the recovery process in people undergoing breast cancer surgery. The results of this study are limited by heterogeneity and the small number of included studies. Future research should prioritize standardization of intervention procedures and investigation of the long-term effects of TENS in postoperative care.RegistrationThis study was registered in the PROSPERO registration system under the number CRD42024523558.
C1 [Akutay, Seda; Kacmaz, Hatice Yuceler] Erciyes Univ, Fac Hlth Sci, Dept Surg Nursing, Kayseri, Turkiye.
   [Ceyhan, Ozlem] Erciyes Univ, Fac Hlth Sci, Dept Internal Nursing, Kayseri, Turkiye.
C3 Erciyes University; Erciyes University
RP Akutay, S (corresponding author), Erciyes Univ, Fac Hlth Sci, Dept Surg Nursing, Kayseri, Turkiye.
EM sedaakutay@erciyes.edu.tr; haticeyclr@erciyes.edu.tr;
   ozlemg@erciyes.edu.tr
RI ceyhan, ozlem/AAL-7730-2021; AKUTAY, SEDA/AAT-1148-2021; Yüceler Kaçmaz,
   Hatice/AAL-6992-2021
OI ceyhan, ozlem/0000-0002-1869-8713; AKUTAY, SEDA/0000-0002-2843-8392;
   Yüceler Kaçmaz, Hatice/0000-0003-4529-1991
FU Scientific and Technological Research Council of Turkiye (TUBITAK)
FX Open access funding provided by the Scientific and Technological
   Research Council of Turkiye (TUBITAK).
CR Ao L, 2021, EXP THER MED, V21, DOI 10.3892/etm.2021.9615
   Barker TH, 2023, JBI EVID SYNTH, V21, P494, DOI 10.11124/JBIES-22-00430
   Bennett MI, 2011, PAIN, V152, P1226, DOI 10.1016/j.pain.2010.12.009
   Bjordal JM, 2003, EUR J PAIN, V7, P181, DOI 10.1016/S1090-3801(02)00098-8
   Castro-Martín E, 2017, ARCH PHYS MED REHAB, V98, P832, DOI 10.1016/j.apmr.2016.11.019
   Elshinnawy AM, 2024, PHYSIOTHER RES INT, V29, DOI 10.1002/pri.2051
   Erden S, 2022, J PERIANESTH NURS, V37, P485, DOI 10.1016/j.jopan.2021.08.017
   Ferlay J, 2010, BREAST CANCER EPIDEMIOLOGY, P1, DOI 10.1007/978-1-4419-0685-4_1
   HAN JS, 1991, PAIN, V47, P295, DOI 10.1016/0304-3959(91)90218-M
   Han ZX, 2023, MED SCI MONITOR, V29, DOI 10.12659/MSM.941262
   Hemmati M, 2022, BMC MUSCULOSKEL DIS, V23, DOI 10.1186/s12891-022-05780-1
   Huang S, 2017, J ANESTH, V31, P58, DOI 10.1007/s00540-015-2057-1
   HUGHES GS, 1984, PHYS THER, V64, P1062, DOI 10.1093/ptj/64.7.1062
   Johnson MI, 2022, MEDICINA-LITHUANIA, V58, DOI 10.3390/medicina58060803
   Johnson MI, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57040378
   Kalra A, 2001, J PHARMACOL EXP THER, V298, P257
   Kannan P, 2022, QUAL LIFE RES, V31, P951, DOI 10.1007/s11136-021-02926-x
   Keelan S, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.622621
   Lu LY, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0285943
   Lu ZH, 2021, J CLIN ANESTH, V74, DOI 10.1016/j.jclinane.2021.110453
   Lukasiewicz S, 2021, CANCERS, V13, DOI 10.3390/cancers13174287
   Mao JJ, 2014, EUR J CANCER, V50, P267, DOI 10.1016/j.ejca.2013.09.022
   MELZACK R, 1965, SCIENCE, V150, P971, DOI 10.1126/science.150.3699.971
   Mendonça Andreza Carvalho Rabelo, 2017, Fisioter. mov., V30, P285, DOI [10.1590/1980-5918.030.s01.ao28, 10.1590/1980-5918.030.s01.ao28]
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n160, 10.1136/bmj.n71, 10.1038/nchembio.2180, 10.1186/s40900-023-00424-7, 10.3390/jpm13020373]
   Reeves BC, 2024, Cochrane Handbook for Systematic Reviews of Interventions
   SALAR G, 1981, PAIN, V10, P169, DOI 10.1016/0304-3959(81)90192-5
   Shinbara H, 2015, ACUPUNCT MED, V33, P65, DOI 10.1136/acupmed-2014-010634
   Silva JG, 2014, J PHYS THER SCI, V26, P349, DOI 10.1589/jpts.26.349
   Sluka KA, 2003, J PAIN, V4, P109, DOI 10.1054/jpai.2003.434
   Szmit M, 2023, ADV CLIN EXP MED, V32, P1063, DOI 10.17219/acem/159703
   Szmit M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10010146
   Tong QY, 2022, CLIN BREAST CANCER, V22, P724, DOI 10.1016/j.clbc.2022.04.010
   Toth MJ, 2020, J APPL PHYSIOL, V128, P1654, DOI 10.1152/japplphysiol.00203.2020
   Vance CGT, 2022, MEDICINA-LITHUANIA, V58, DOI 10.3390/medicina58101332
   Vickers AJ, 2018, J PAIN, V19, P455, DOI 10.1016/j.jpain.2017.11.005
   Viderman D, 2024, J CLIN MED, V13, DOI 10.3390/jcm13020427
   Wang XQ, 2010, J NEUROSURG ANESTH, V22, P128, DOI 10.1097/ANA.0b013e3181c9fbde
   Yan WL, 2023, PAIN THER, V12, P631, DOI 10.1007/s40122-023-00496-z
   Yao YS, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/324360
   Zhang Q, 2014, ANAESTHESIA, V69, P832, DOI 10.1111/anae.12639
   Zhang YY, 2023, SURGERY, V174, P787, DOI 10.1016/j.surg.2023.06.014
NR 42
TC 0
Z9 1
U1 5
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD FEB
PY 2025
VL 33
IS 2
AR 90
DI 10.1007/s00520-024-09129-3
PG 16
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA S3I4Q
UT WOS:001397200600003
PM 39804405
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Wang, Y
   Fang, J
   Zhou, YL
   Lyu, Z
AF Wang, Yang
   Fang, Jie
   Zhou, Youlong
   Lyu, Zhifeng
TI Transcutaneous Electrical Acupoint Stimulation: Research Progress in
   Clinical Application (Review)
SO ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH
LA English
DT Review
DE Transcutaneous electrical acupoint stmulation (TEAS); Clinical
   application; Perioperative period
ID ACUPUNCTURE POINT STIMULATION; ELDERLY-PATIENTS; POSTOPERATIVE RECOVERY;
   PAIN; PREVENTION; DISEASE; SURGERY; STRESS; CANCER; TEAS
AB Transcutaneous electrical acupoint stimulation (TEAS) has become an important method for the treatment of diseases, which can be used alone or as a complementary mthod. TEAS combines the benefits of transcutaneous electrical Received: 4 July 2021/Accepted: 5 May 2022 nerve stimulation (TENS) and acupuncture, and it is welcomed by clinicians because Absr ct:Transc taneous el ctrical acupointimulatio(TEAS) habcome an of its safety and significant treatment effect . For instance, TEAS is helpful for importan mehod for t e treatmen of diseaes, which cabusd aone or s a sedation and analgesia, promotes gastrointestinal function re covery, reduces the occurrnce of postoperative cognitive dysfunction (POCD), postoperative nausea and complementary method. TEAS combines the benefits of transcutaneous elect ical vomiting (PONV), and other adverse reactios, enhances imune fucto, protects nerve stimulation (TENS) and acupuncture, and it is welcomed by clinicians because rgan funcion, accelerates he recovery of patients, improves the prognosis, and of its safety a d significant treatment effect. For i stance, TEAS is helpfu for enhnces patients' comfort degre. On this basis, more functions f TEAS need to bsedation and ana gesia, promote gastro ntestinal function recovery, reduces the occurnce of postopertive cognitive dysfunction (POCD), posto explored, and its clinical applications need to be further promoted.
C1 [Wang, Yang] Henan Univ Chinese Med, Clin Med Coll 1, Zhengzhou, Henan, Peoples R China.
   [Fang, Jie; Lyu, Zhifeng] Henan Univ Chinese Med, Dept Anesthesiol, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China.
   [Zhou, Youlong] Henan Univ Chinese Med, Dept Acupuncture & Pain, Affiliated Hosp 3, Zhengzhou, Henan, Peoples R China.
   [Lyu, Zhifeng] Henan Univ Chinese Med, Dept Anesthesiol, Affiliated Hosp 1, 19 Renmin Rd, Zhengzhou 450052, Henan, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Henan University of
   Traditional Chinese Medicine; Henan University of Traditional Chinese
   Medicine; Henan University of Traditional Chinese Medicine
RP Lyu, Z (corresponding author), Henan Univ Chinese Med, Dept Anesthesiol, Affiliated Hosp 1, 19 Renmin Rd, Zhengzhou 450052, Henan, Peoples R China.
EM mazui1846@126.com
CR Ao L, 2021, EXP THER MED, V21, DOI 10.3892/etm.2021.9615
   Bai WY, 2018, J NEUROSURG ANESTH, V30, P337, DOI 10.1097/ANA.0000000000000460
   Chen YM, 2021, ACUPUNCT MED, V39, P292, DOI 10.1177/0964528420960479
   Chi YL, 2019, AM J CHINESE MED, V47, P1445, DOI 10.1142/S0192415X19500745
   Deng KF, 2021, J ACUPUNCT TUINA SCI, V19, P78, DOI 10.1007/s11726-021-1229-9
   Feng B, 2019, PSYCHIAT CLIN NEUROS, V73, P179, DOI 10.1111/pcn.12810
   Feng B, 2016, J PSYCHIATR RES, V80, P30, DOI 10.1016/j.jpsychires.2016.05.015
   Gao F, 2018, CLIN INTERV AGING, V13, P2127, DOI 10.2147/CIA.S183698
   Hadadian F, 2016, J CLIN DIAGN RES, V10, pYC1, DOI 10.7860/JCDR/2016/19516.8532
   Han JS, 2003, TRENDS NEUROSCI, V26, P17, DOI 10.1016/S0166-2236(02)00006-1
   Hou LL, 2013, CANCER NURS, V36, P139, DOI 10.1097/NCC.0b013e3182483415
   Hou LL, 2017, J THORAC DIS, V9, P809, DOI 10.21037/jtd.2017.03.12
   Huang J, 2020, CHINA MEDICAL ABSTRA, V37, P141
   Huang S, 2017, J ANESTH, V31, P58, DOI 10.1007/s00540-015-2057-1
   Huang Wei, 2018, Zhen Ci Yan Jiu, V43, P611, DOI 10.13702/j.1000-0607.180005
   Li HZ, 2019, CLIN INTERV AGING, V14, P1607, DOI 10.2147/CIA.S210751
   Liu XM, 2015, J ALTERN COMPLEM MED, V21, P610, DOI 10.1089/acm.2014.0284
   MELZACK R, 1965, SCIENCE, V150, P971, DOI 10.1126/science.150.3699.971
   Miao Wei-Juan, 2020, Zhongguo Zhen Jiu, V40, P615, DOI 10.13703/j.0255-2930.20190824-0001
   Mo YC, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/8369737
   Ni XL, 2012, PEDIATR ANESTH, V22, P805, DOI 10.1111/j.1460-9592.2012.03822.x
   Qu F, 2017, EXPLORE-NY, V13, P306, DOI 10.1016/j.explore.2017.06.004
   Qu F, 2017, J ZHEJIANG UNIV-SC B, V18, P186, DOI 10.1631/jzus.B1600437
   Song BJ, 2020, NAT SCI SLEEP, V12, P809, DOI 10.2147/NSS.S270739
   Song Y, 2020, J INT MED RES, V48, DOI 10.1177/0300060520910052
   Sun K, 2017, CLIN J PAIN, V33, P340, DOI 10.1097/AJP.0000000000000400
   Sun S L, 1989, Sheng Li Xue Bao, V41, P416
   Tu Q, 2018, TECHNOL CANCER RES T, V17, DOI 10.1177/1533033818806477
   Tu Q, 2019, UROLITHIASIS, V47, P279, DOI 10.1007/s00240-018-1056-8
   Wu ZY, 2015, J TRADIT CHIN MED, V35, P134, DOI 10.1016/S0254-6272(15)30020-0
   Xie J, 2017, CHIN J CANCER, V36, DOI 10.1186/s40880-016-0176-1
   Yang XY, 2015, BRIT J ANAESTH, V115, P883, DOI 10.1093/bja/aev352
   Yao YS, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/324360
   Yin CP, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000013814
   Yu XD, 2019, ACUPUNCT MED, V37, P312, DOI 10.1136/acupmed-2017-011536
   Zhang W, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/5650413
   Zhao WL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0116976
   Zhou DD, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/7341920
   Zhou X, 2021, CANCER MANAG RES, V13, P1449, DOI 10.2147/CMAR.S292325
NR 39
TC 2
Z9 2
U1 8
U2 66
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0360-1293
EI 2167-9010
J9 ACUPUNCTURE ELECTRO
JI Acupunct. Electro-Ther. Res.
PY 2022
VL 47
IS 4
BP 379
EP 390
DI 10.3727/036012921X16341481788249
PG 12
WC Integrative & Complementary Medicine; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Neurosciences & Neurology
GA 6I1YR
UT WOS:000885927000001
DA 2026-01-16
ER

PT J
AU Zhang, F
   Zhou, H
   Ding, SY
   Zhang, D
   Lian, DS
   Chen, XL
   Wang, C
AF Zhang, Feng
   Zhou, Hao
   Ding, Songyi
   Zhang, Da
   Lian, Daoshi
   Chen, Xingliang
   Wang, Chao
TI Efficacy and safety of acupuncture for recurrent aphthous stomatitis: a
   systematic review protocol
SO BMJ OPEN
LA English
DT Review
DE pain management; health & safety; protocols & guidelines
ID CANCER
AB Introduction Recurrent aphthous stomatitis (RAS) is a distressing symptom. There are many ways to treat RAS, such as pudilan anti-inflammatory oral liquid and doxycycline and laser therapy, but these take a long time to produce positive effects and compliance is low. Previous reviews of acupuncture treatment for RAS has been growing, but a systematic review is not available. To assess the efficacy and safety of acupuncture for the management of RAS. Methods and analysis The following databases will be searched from their inception to 1 February 2020: PubMed, Embase, Cochrane Library, CINAHL, Chinese Biomedical Literature Database, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure and Wanfang. The randomised controlled trials in English or Chinese associated with acupuncture for patients with RAS will be included. Eligible study conference abstracts and reference lists of manuscripts will also be searched. Two reviewers will select the studies, extract data independently. The Cochrane risk of bias tool will be used to assess the risk of bias for the studies. According to heterogeneity testing, data will be synthesised using a random-effects model. A meta-analysis will be performed using Rev Man V.5.3.5 statistical software for each outcome. Subgroup analysis and sensitivity analysis are planned according to clinical evidence. Mean difference or standardised mean difference for continuous data and risk ratio for dichotomous data will be calculated. Ethics and dissemination No ethical approval is required. This protocol will not involve individual patient information and endangering participant rights. The results will be reported in a peer-reviewed journal or disseminated in relevant conferences. OSF registration number DOI 10.17605/OSF.IO/QASUY.
C1 [Zhang, Feng; Lian, Daoshi; Chen, Xingliang; Wang, Chao] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
   [Zhou, Hao; Ding, Songyi; Zhang, Da; Wang, Chao] Sichuan Integrat Med Hosp, Subhlth Ctr, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Wang, C (corresponding author), Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.; Wang, C (corresponding author), Sichuan Integrat Med Hosp, Subhlth Ctr, Chengdu, Peoples R China.
EM wangchaotcm@126.com
RI Zhou, Hao/HZL-8044-2023
FU administration science and technology project of traditional Chinese
   medicine of Sichuan provincial [2018LC001]; emphasis science and
   technology department of Sichuan Science and technology department
   [2018SZ0408];  [2020100]
FX The administration science and technology project of traditional Chinese
   medicine of Sichuan provincial (2018LC001). The emphasis science and
   technology department of Sichuan Science and technology department
   (2018SZ0408). Infrared visualization study of the subjective and
   objective consistency of 'disease-syndrome--symptom' in perimenopausal
   women with subhealthy insomnia based on the theory of 'yin deficiency
   leads to internal heat' (2020100).
CR Akintoye Sunday O, 2014, Dent Clin North Am, V58, P281, DOI 10.1016/j.cden.2013.12.002
   Altenburg A, 2007, J EUR ACAD DERMATOL, V21, P1019, DOI 10.1111/j.1468-3083.2007.02393.x
   Bulut N, 2015, J BUON, V20, P1276
   Chen Yan-ming, 2006, Zhongguo Zhen Jiu, V26, P103
   Eisen D, 2001, CUTIS, V68, P201
   El-Wakeel NM, 2019, J INVESTIG CLIN DENT, V10, DOI 10.1111/jicd.12437
   Giammarinaro Enrica, 2019, J Contemp Dent Pract, V20, P1249, DOI 10.5005/jp-journals-10024-2709
   Habibzadeh S, 2021, J DERMATOL TREAT, V32, P361, DOI 10.1080/09546634.2019.1654597
   Jin Y. G., 2017, PPAR RES, V2017, P1
   Joseph RM, 2016, SEMIN ARTHRITIS RHEU, V46, P133, DOI 10.1016/j.semarthrit.2016.03.001
   Krisdapong S, 2012, QUAL LIFE RES, V21, P71, DOI 10.1007/s11136-011-9925-4
   Nayir E, 2015, J BUON, V20, P1606
   Piacentini M, 2019, J CLIN PHARM THER, V44, P838, DOI 10.1111/jcpt.13022
   Sami AS, 2021, J MATERN-FETAL NEO M, V34, P1055, DOI 10.1080/14767058.2019.1623872
   Ship JA, 2000, QUINTESSENCE INT, V31, P95
   Stehlikova Z, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7120636
   Stokowski R, 2015, PRENATAL DIAG, V35, P1243, DOI 10.1002/pd.4686
   Sun N, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-034290
   Yildirimyan N, 2019, ORAL HLTH PREV DENT, V17, P465, DOI 10.3290/j.ohpd.a42736
   Zhang F, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000018900
   Zhou PR, 2017, J AM DENT ASSOC, V148, P17, DOI 10.1016/j.adaj.2016.08.025
NR 21
TC 2
Z9 2
U1 1
U2 17
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2020
VL 10
IS 10
AR e037603
DI 10.1136/bmjopen-2020-037603
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OI5DD
UT WOS:000583298100001
PM 33033019
OA Green Submitted, Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Larbi, OM
   Jiang, C
   McLane, B
   Wang, GM
   Daunov, K
   Hobson, SM
   Daly, B
   Mazanec, SR
   Feyes, D
   Rodgers-Melnick, S
   Li, M
   Momotaz, H
   Lee, RT
AF Larbi, Olivia M.
   Jiang, Cherry
   McLane, Bethanny
   Wang, Gi-Ming
   Daunov, Katherine
   Hobson, Sean M.
   Daly, Barbara
   Mazanec, Susan R.
   Feyes, Denise
   Rodgers-Melnick, Samuel
   Li, Ming
   Momotaz, Hasina
   Lee, Richard T.
TI Interest and Willingness to Pay for Integrative Therapies of Patients
   With Cancer and Caregivers
SO JCO ONCOLOGY PRACTICE
LA English
DT Article; Proceedings Paper
CT 3rd Annual Cancer Disparities Symposium of the
   Case-Comprehensive-Cancer-Center
CY MAR, 2019
CL Cleveland, OH
SP Case Comprehens Canc Ctr
ID ALTERNATIVE MEDICINE; FINANCIAL TOXICITY; COMPLEMENTARY; PAIN
AB PURPOSE Complementary and integrative medicine (CIM) services are more prevalent in cancer centers but continue to be underutilized by patients. This study examines perspectives from patients and caregivers about these services being offered at a comprehensive cancer center.
   METHODS Patients and caregivers were surveyed about their familiarity, interest, and experience with five CIM therapies: acupuncture, massage, meditation, music therapy, and yoga. Respondents were also asked about their interest when recommended by their medical team and when offered in a clinical trial as well as their willingness to pay for these services. Respondents were also asked about perceived barriers to accessing these services. Chi-squared tests were performed to explore associations between past experience, interest levels, and willingness to pay.
   RESULTS A total of 576 surveys were obtained (464 patients and 112 caregivers). Most respondents identified as White or Caucasian (65.6%), female (57.2%), had been a patient for < 3 years (74.2%), had some college education (73.8%), and made > $40,000 in US dollars as their annual household income (69.1%). Respondents were most familiar with therapeutic massage (34.2%) and least familiar with acupuncture (20.0%). The average interest in these services increased from 53.3% to 64.1% when recommended by a medical professional. Respondents were most willing to pay $1-60 for therapeutic massage (62.3%) and least willing to pay for meditation (43.7%). The main barriers to accessing CIM services were cost (56.0%) and lack of knowledge (52.1%).
   CONCLUSION Overall, a significant proportion of patients and caregivers were unfamiliar with these five integrative therapies. Increasing education, decreasing cost, and a recommendation by medical professionals would improve CIM usage. (C) 2021 by American Society of Clinical Oncology
C1 [Larbi, Olivia M.; Jiang, Cherry; Wang, Gi-Ming; Daly, Barbara; Mazanec, Susan R.; Li, Ming; Momotaz, Hasina] Case Western Reserve Univ, Cleveland, OH 44106 USA.
   [McLane, Bethanny; Daunov, Katherine; Hobson, Sean M.; Rodgers-Melnick, Samuel; Lee, Richard T.] Univ Hosp Seidman Canc Ctr, Cleveland, OH 44106 USA.
   [Feyes, Denise; Lee, Richard T.] Case Western Reserve Univ, Comprehens Canc Ctr, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; University
   System of Ohio; Case Western Reserve University
RP Lee, RT (corresponding author), Univ Hosp Seidman Canc Ctr, Med, 11100 Euclid Ave, Cleveland, OH 44106 USA.; Lee, RT (corresponding author), Univ Hosp Seidman Canc Ctr, Support & Integrat Oncol, 11100 Euclid Ave, Cleveland, OH 44106 USA.; Lee, RT (corresponding author), Case Western Reserve Univ, Sch Med, Integrat Oncol, 11100 Euclid Ave, Cleveland, OH 44106 USA.
EM Richard.T.Lee@case.edu
RI Rodgers-Melnick, Samuel/ABK-4891-2022; Lee, Richard/AAS-1416-2021
OI Daunov, Katherine/0000-0001-8734-2529; Lee, Richard/0000-0001-9916-6155
FU University Hospitals Seidman Cancer Center, Case Comprehensive Cancer
   Center,; Helen Moss Foundation-Schoff Family Professorship in
   Integrative Oncology
FX Supported by University Hospitals Seidman Cancer Center, Case
   Comprehensive Cancer Center, and Helen Moss Foundation-Schoff Family
   Professorship in Integrative Oncology.
CR Astin JA, 1998, JAMA-J AM MED ASSOC, V279, P1548, DOI 10.1001/jama.279.19.1548
   Carrera PM, 2018, CA-CANCER J CLIN, V68, P153, DOI 10.3322/caac.21443
   Chou R, 2017, ANN INTERN MED, V166, P493, DOI 10.7326/M16-2459
   Dusek JA, 2018, J ALTERN COMPLEM MED, V24, P557, DOI 10.1089/acm.2017.0203
   Horrigan B., 2012, GLOBAL ADV HLTH MED, V1, P18, DOI [10.7453/gahmj.2012.1.3.006, DOI 10.7453/GAHMJ.2012.1.3.006]
   Liou KT, 2019, PAIN MED, V20, P2060, DOI 10.1093/pm/pnz087
   Lyman GH, 2018, J CLIN ONCOL, V36, P2647, DOI 10.1200/JCO.2018.79.2721
   Mao JJ, 2011, J CANCER SURVIV, V5, P8, DOI 10.1007/s11764-010-0153-7
   Montross-Thomas LP, 2017, J ALTERN COMPLEM MED, V23, P259, DOI 10.1089/acm.2016.0288
   Sherman Karen J, 2004, BMC Complement Altern Med, V4, P9, DOI 10.1186/1472-6882-4-9
   Swarm RA, 2019, J NATL COMPR CANC NE, V17, P977, DOI 10.6004/jnccn.2019.0038
   Zafar SY, 2013, ONCOLOGIST, V18, P381, DOI 10.1634/theoncologist.2012-0279
NR 12
TC 14
Z9 14
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2688-1527
EI 2688-1535
J9 JCO ONCOL PRACT
JI JCO Oncol. Pract.
PD NOV
PY 2021
VL 17
IS 11
BP 672
EP +
DI 10.1200/OP.20.00471
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology
GA ZC1JK
UT WOS:000757284900006
PM 33492981
OA Bronze
DA 2026-01-16
ER

PT J
AU Teixeira, MZ
   Guedes, CHFF
   Barreto, PV
   Martins, MA
AF Teixeira, Marcus Z.
   Guedes, Cristina H. F. F.
   Barreto, Patricia V.
   Martins, Milton A.
TI The placebo effect and homeopathy
SO HOMEOPATHY
LA English
DT Article
DE Placebo; Nocebo; Specific effects; Non-specific effects; Expectation;
   Conditioning; Imaging; qEEG; Homeopathy; Acupuncture
ID IRRITABLE-BOWEL-SYNDROME; RANDOMIZED CONTROLLED-TRIALS; ALTERNATIVE
   MEDICINE USE; LOW-BACK-PAIN; COMPLEMENTARY MEDICINE; PARKINSONS-DISEASE;
   CANCER-PATIENTS; PATIENT EXPECTATIONS; NATIONAL-SURVEY; UNITED-STATES
AB Background: Like other forms of medicine, including Complementary and Alternative Medicine (CAM), homeopathy elicits expectations in patients. The physician-patient relationship, personal and comprehensive treatment and lack of adverse effects are elements in creating positive expectations. Other elements may be associated with negative expectations.
   Methods: We conducted a systematic literature review on placebo and nocebo effects in acupuncture and homeopathy using Medline.
   Results: Findings on the psychophysiological and neuromediating mechanisms of the placebo-nocebo phenomenon are reviewed. Studies of these effects reveal how expectations and unconscious conditioning can be measured by imaging and EEG methods. They result in significant, non-specific therapeutic effects, which may confuse the evaluation of the specific therapeutic effects treatment, hampering selection of the simillimum.
   Conclusions: Directions for future research on non-specific therapeutic effects of homeopathy to improve clinical practice and clinical research are discussed. Homeopathy (2010) 99, 119-129.
C1 [Teixeira, Marcus Z.; Guedes, Cristina H. F. F.; Barreto, Patricia V.; Martins, Milton A.] Univ Sao Paulo, Dept Internal Med, Sch Med, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Teixeira, MZ (corresponding author), Hosp Clin FMUSP, Serv Clin Med Geral, Av Dr Eneas Carvalho Aguiar 155,4 Andar,Bloco 6, BR-05403900 Sao Paulo, Brazil.
EM marcus@homeozulian.med.br
RI guedes, cristina/H-2889-2015; Teixeira, Marcus Zulian/A-7294-2008;
   Martins, Milton/D-6658-2012
OI Teixeira, Marcus Zulian/0000-0002-3338-8588; 
CR Amanzio M, 2001, PAIN, V90, P205, DOI 10.1016/S0304-3959(00)00486-3
   Amanzio M, 1999, J NEUROSCI, V19, P484, DOI 10.1523/JNEUROSCI.19-01-00484.1999
   Astin JA, 1998, JAMA-J AM MED ASSOC, V279, P1548, DOI 10.1001/jama.279.19.1548
   Bausell RB, 2005, EVAL HEALTH PROF, V28, P9, DOI 10.1177/0163278704273081
   Bell IR, 2004, INT J NEUROSCI, V114, P1195, DOI 10.1080/00207450490475724
   Bell IR, 2004, J ALTERN COMPLEM MED, V10, P285, DOI 10.1089/107555304323062275
   Bell IR, 2004, J ALTERN COMPLEM MED, V10, P269, DOI 10.1089/107555304323062266
   Ben Arush M, 2006, J PEDIAT HEMATOL ONC, V28, P141
   Benedetti F, 2007, NEUROSCIENCE, V147, P260, DOI 10.1016/j.neuroscience.2007.02.020
   Benedetti F, 2003, J NEUROSCI, V23, P4315
   Benedetti F, 1999, EUR J NEUROSCI, V11, P625, DOI 10.1046/j.1460-9568.1999.00465.x
   Benedetti F, 1996, PAIN, V64, P535, DOI 10.1016/0304-3959(95)00179-4
   BENEDETTI F, 1995, LANCET, V346, P1231, DOI 10.1016/S0140-6736(95)92938-X
   BIGNAMINI M, 1987, Clinica Terapeutica, V122, P429
   Brien S, 2004, J ALTERN COMPLEM MED, V10, P499, DOI 10.1089/1075553041323768
   Buettner C, 2006, BREAST CANCER RES TR, V100, P219, DOI 10.1007/s10549-006-9239-3
   Burg MA, 1998, SOUTHERN MED J, V91, P1126, DOI 10.1097/00007611-199812000-00006
   Cherkin DC, 2009, ARCH INTERN MED, V169, P858, DOI 10.1001/archinternmed.2009.65
   Cho HJ, 2005, PSYCHOSOM MED, V67, P301, DOI 10.1097/01.psy.0000156969.76986.e0
   Colloca L, 2004, LANCET NEUROL, V3, P679, DOI 10.1016/S1474-4422(04)00908-1
   de Craen AJM, 1999, J ROY SOC MED, V92, P511, DOI 10.1177/014107689909201005
   de la Fuente-Fernández R, 2004, BIOL PSYCHIAT, V56, P67, DOI 10.1016/j.biopsych.2003.11.019
   de la Fuente-Fernández R, 2001, SCIENCE, V293, P1164, DOI 10.1126/science.1060937
   De Pascalis V, 2002, PAIN, V96, P393, DOI 10.1016/S0304-3959(01)00485-7
   Dorn SD, 2007, NEUROGASTROENT MOTIL, V19, P630, DOI 10.1111/j.1365-2982.2007.00937.x
   EISENBERG DM, 1993, NEW ENGL J MED, V328, P246, DOI 10.1056/NEJM199301283280406
   Eisenberg DM, 1998, JAMA-J AM MED ASSOC, V280, P1569, DOI 10.1001/jama.280.18.1569
   FISHER P, 1994, BRIT MED J, V309, P107, DOI 10.1136/bmj.309.6947.107
   Fisher P, 2006, HOMEOPATHY, V95, P215, DOI 10.1016/j.homp.2006.07.006
   Fournier JC, 2010, JAMA-J AM MED ASSOC, V303, P47, DOI 10.1001/jama.2009.1943
   Frei H, 2007, HOMEOPATHY, V96, P35, DOI 10.1016/j.homp.2006.11.004
   Fricchione G, 2005, MED SCI MONITOR, V11, pMS54
   FURNHAM A, 1994, J CLIN PSYCHOL, V50, P458, DOI 10.1002/1097-4679(199405)50:3<458::AID-JCLP2270500318>3.0.CO;2-V
   Geers AL, 2006, J BEHAV MED, V29, P171, DOI 10.1007/s10865-005-9040-5
   Goebel MU, 2002, FASEB J, V16, P1869, DOI 10.1096/fj.02-0389com
   HAHNEMANN S, 1991, ORGANON MED
   Hill PB, 2009, VET REC, V164, P364, DOI 10.1136/vr.164.12.364
   Hróbjartsson A, 2004, J INTERN MED, V256, P91, DOI 10.1111/j.1365-2796.2004.01355.x
   Hunsley J, 2007, J CLIN PSYCHOL, V63, P391, DOI 10.1002/jclp.20352
   Ilnyckyj A, 1997, GASTROENTEROLOGY, V112, P1854, DOI 10.1053/gast.1997.v112.pm9178676
   Kaptchuk TJ, 2008, BMJ-BRIT MED J, V336, P999, DOI 10.1136/bmj.39524.439618.25
   Keltner JR, 2006, J NEUROSCI, V26, P4437, DOI 10.1523/JNEUROSCI.4463-05.2006
   Kirsch I., 1998, Prevention Treatment, V1, DOI DOI 10.1037/1522-3736.1.1.12A
   Kirsch I, 2008, PLOS MED, V5, P260, DOI 10.1371/journal.pmed.0050045
   Kong J, 2008, J NEUROSCI, V28, P13354, DOI 10.1523/JNEUROSCI.2944-08.2008
   Koyama T, 2005, P NATL ACAD SCI USA, V102, P12950, DOI 10.1073/pnas.0408576102
   Laengler A, 2008, EUR J CANCER, V44, P2233, DOI 10.1016/j.ejca.2008.07.020
   Launso L, 2007, HOMEOPATHY, V96, P233, DOI 10.1016/j.homp.2007.08.011
   Leuchter AF, 2002, AM J PSYCHIAT, V159, P122, DOI 10.1176/appi.ajp.159.1.122
   LEVINE JD, 1979, P NATL ACAD SCI USA, V76, P3528, DOI 10.1073/pnas.76.7.3528
   Lewith GT, 2005, EVID-BASED COMPL ALT, V2, P315, DOI 10.1093/ecam/neh110
   Linde K, 2007, PAIN, V128, P264, DOI 10.1016/j.pain.2006.12.006
   Macedo A, 2008, EUR J PAIN, V12, P68, DOI 10.1016/j.ejpain.2007.03.002
   Marian F, 2008, BMC COMPLEM ALTERN M, V8, DOI 10.1186/1472-6882-8-52
   Mayberg HS, 2002, AM J PSYCHIAT, V159, P728, DOI 10.1176/appi.ajp.159.5.728
   McRae C, 2004, ARCH GEN PSYCHIAT, V61, P412, DOI 10.1001/archpsyc.61.4.412
   Molassiotis A, 2006, SUPPORT CARE CANCER, V14, P260, DOI 10.1007/s00520-005-0883-7
   Myers SS, 2008, J GEN INTERN MED, V23, P148, DOI 10.1007/s11606-007-0460-5
   OLNESS K, 1992, J DEV BEHAV PEDIATR, V13, P124, DOI 10.1097/00004703-199204000-00008
   Pariente J, 2005, NEUROIMAGE, V25, P1161, DOI 10.1016/j.neuroimage.2005.01.016
   Patel SM, 2005, NEUROGASTROENT MOTIL, V17, P332, DOI 10.1111/j.1365-2982.2005.00650.x
   Paterson C, 2005, BMJ-BRIT MED J, V330, P1202, DOI 10.1136/bmj.330.7501.1202
   Petrovic P, 2002, SCIENCE, V295, P1737, DOI 10.1126/science.1067176
   Pollo A, 2002, NEUROREPORT, V13, P1383, DOI 10.1097/00001756-200208070-00006
   Price DD, 2001, PAIN, V90, P201, DOI 10.1016/S0304-3959(01)00265-2
   Price DD, 2008, ANNU REV PSYCHOL, V59, P565, DOI 10.1146/annurev.psych.59.113006.095941
   Price DD, 2007, PAIN, V127, P63, DOI 10.1016/j.pain.2006.08.001
   Sauro MD, 2005, J PSYCHOSOM RES, V58, P115, DOI 10.1016/j.jpsychores.2004.07.001
   Su CY, 2004, GASTROENTEROLOGY, V126, P1257, DOI 10.1053/j.gastro.2004.01.024
   Sysko R, 2007, J CLIN PSYCHIAT, V68, P1213, DOI 10.4088/JCP.v68n0807
   Teixeira MZ, 2007, REV ASSOC MED BRAS, V53, P547, DOI 10.1590/S0104-42302007000600026
   Teixeira MZ, 2009, REV ASSOC MED BRAS, V55, P13, DOI 10.1590/S0104-42302009000100008
   TEIXEIRA MZ, 2009, THESIS U SAO PAULO S
   Thompson Trevor D B, 2006, BMC Complement Altern Med, V6, P37
   Tilburt JC, 2008, BRIT MED J, V337, DOI 10.1136/bmj.a1938
   Träger-Maury S, 2007, B CANCER, V94, P1017
   *U SAO PAUL, EFF IND HOM TREATM P
   Van Wassenhoven M, 2004, Homeopathy, V93, P3, DOI 10.1016/j.homp.2003.11.010
   Vase L, 2005, PAIN, V115, P338, DOI 10.1016/j.pain.2005.03.014
   Veeramah EK, 2000, J R SOC PROMO HEALTH, V120, P42, DOI 10.1177/146642400012000117
   Wager TD, 2004, SCIENCE, V303, P1162, DOI 10.1126/science.1093065
   Walsh BT, 2002, JAMA-J AM MED ASSOC, V287, P1840, DOI 10.1001/jama.287.14.1840
   WAMPOLD BE, 2005, J CLIN PSYCHOL, V63, P373
NR 83
TC 15
Z9 18
U1 3
U2 46
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1475-4916
EI 1476-4245
J9 HOMEOPATHY
JI Homeopathy
PD APR
PY 2010
VL 99
IS 2
BP 119
EP 129
DI 10.1016/j.homp.2010.02.001
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 609CC
UT WOS:000278631700006
PM 20471615
DA 2026-01-16
ER

PT J
AU Roberts, K
   Rickett, K
   Greer, R
   Woodward, N
AF Roberts, Kate
   Rickett, Kirsty
   Greer, Ristan
   Woodward, Natasha
TI Management of aromatase inhibitor induced musculoskeletal symptoms in
   postmenopausal early Breast cancer: A systematic review and
   meta-analysis
SO CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
LA English
DT Review
DE Aromatase inhibitors; Letrozole; Exemestane; Anastrozole; AIMSS;
   Musculoskeletal symptoms; Arthralgias; Breast cancer
ID ADJUVANT ANASTROZOLE THERAPY; RANDOMIZED CLINICAL-TRIAL;
   QUALITY-OF-LIFE; INDUCED ARTHRALGIA; JOINT SYMPTOMS; DOUBLE-BLIND;
   RISK-FACTORS; BONE PAIN; FOLLOW-UP; PHASE-II
AB Aromatase Inhibitors (Al) are widely used for the adjuvant treatment of hormone receptor positive breast cancers in the post-menopausal population. AI are often associated with significant joint and muscular symptoms; symptoms that are commonly referred to as aromatase inhibitor-associated musculoskeletal syndrome (AIMSS). AIMSS adversely impacts health-related quality of life of many patients, and reduces Al compliance. Although there are informal practice recommendations, the limited current level of evidence for management of AIMSS for breast cancer patients on aromatase inhibitors has made development of formal guidelines challenging, and remains an unmet need. This is the first systematic review to consider the evidence for all pharmacological and non-pharmacological interventions in the treatment of AIMSS, including physical therapy, acupuncture and complementary therapies. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Roberts, Kate; Woodward, Natasha] Mater Hlth Serv, Dept Med Oncol, Brisbane, Qld, Australia.
   [Rickett, Kirsty; Greer, Ristan; Woodward, Natasha] Univ Queensland, Brisbane, Qld, Australia.
   [Greer, Ristan; Woodward, Natasha] Mater Med Res Inst Mater Hlth Serv, Brisbane, Qld, Australia.
C3 Mater Health Services; University of Queensland; Mater Health Services;
   University of Queensland; Mater Research
RP Roberts, K (corresponding author), Mater Hlth Serv, Dept Med Oncol, Brisbane, Qld, Australia.
EM Kate.Roberts@health.q1d.gov.au
RI Greer, Ristan/N-6948-2015; Woodward, Natasha Elizabeth/G-4054-2015;
   Rickett, Kirsty/B-3691-2015; Roberts, Kate/D-2719-2017
OI Greer, Ristan/0000-0002-1574-4729; Woodward, Natasha
   Elizabeth/0000-0003-0944-4807; 
CR [Anonymous], QI HERB AP NAT CHOIC
   [Anonymous], 2016, NATURAL MED COMPREHE
   Aydiner A, 2013, BREAST, V22, P121, DOI 10.1016/j.breast.2013.01.014
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Birrell S, 2010, TESTOSTERONE UNDECAN, V69
   Briot K, 2010, BREAST CANCER RES TR, V120, P127, DOI 10.1007/s10549-009-0692-7
   Burstein HJ, 2007, BREAST, V16, P223, DOI 10.1016/j.breast.2007.01.011
   Cantarero-Villanueva I, 2013, CLIN REHABIL, V27, P123, DOI 10.1177/0269215512448256
   Chien TJ, 2015, J ALTERN COMPLEM MED, V21, P251, DOI 10.1089/acm.2014.0083
   Coates AS, 2007, J CLIN ONCOL, V25, P486, DOI 10.1200/JCO.2006.08.8617
   Coleman RE, 2008, CANCER TREAT REV, V34, P275, DOI 10.1016/j.ctrv.2007.10.004
   Crew Katherine D, 2007, J Cancer Surviv, V1, P283, DOI 10.1007/s11764-007-0034-x
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Cuzick J, 2010, LANCET ONCOL, V11, P1135, DOI 10.1016/S1470-2045(10)70257-6
   DeNysschen CA, 2014, EUR J CANCER CARE, V23, P493, DOI 10.1111/ecc.12155
   Deshpande Prasanna R, 2011, Perspect Clin Res, V2, P137, DOI 10.4103/2229-3485.86879
   Fields J., 2015, A feasibility study of a Nordic walking intervention for women experiencing aromatase inhibitor associated arthralgia
   Galantino ML, 2013, ALTERN THER HEALTH M, V19, P38
   Galantino ML, 2012, INTEGR CANCER THER, V11, P313, DOI 10.1177/1534735411413270
   Goss PE, 2016, NEW ENGL J MED, V375, P209, DOI 10.1056/NEJMoa1604700
   Greenlee H, 2013, SUPPORT CARE CANCER, V21, P1077, DOI 10.1007/s00520-012-1628-z
   Hadji P, 2014, ANN ONCOL, V25, P372, DOI 10.1093/annonc/mdt513
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Henry NL, 2011, CANCER-AM CANCER SOC, V117, P5469, DOI 10.1002/cncr.26230
   Hershman DL, 2015, J CLIN ONCOL, V33, P1910, DOI 10.1200/JCO.2014.59.5595
   Hershman DL, 2011, BREAST CANCER RES TR, V126, P529, DOI 10.1007/s10549-010-1132-4
   Howell A, 2005, LANCET, V365, P60, DOI 10.1016/s0140-6736(04)17666-6
   Ingle JN, 2006, BREAST CANCER RES TR, V99, P295, DOI 10.1007/s10549-006-9207-y
   Irwin ML, 2015, J CLIN ONCOL, V33, P1104, DOI 10.1200/JCO.2014.57.1547
   Jacobsen PB, 2015, PSYCHO-ONCOLOGY, V24, P1578, DOI 10.1002/pon.3756
   Jadad AR, 1996, CONTROL CLIN TRIALS, V17, P1, DOI 10.1016/0197-2456(95)00134-4
   Kadakia KC, 2016, ASCO ANN M P
   Khan QJ, 2012, J CLIN ONCOL, V30
   Khan QJ, 2010, BREAST CANCER RES TR, V119, P111, DOI 10.1007/s10549-009-0495-x
   Kiyomi A, 2015, J CANCER, V6, P367, DOI 10.7150/jca.10695
   Kubo M, 2012, ANTICANCER RES, V32, P2331
   Laroche F, 2014, J PAIN, V15, P293, DOI 10.1016/j.jpain.2013.11.004
   Lash BW, 2011, J CLIN ONCOL, V29, DOI 10.1200/jco.2011.29.15_suppl.e19725
   Lintermans A, 2013, ANN ONCOL, V24, P350, DOI 10.1093/annonc/mds290
   Liu P, 2014, GENET MOL RES, V13, P5285, DOI 10.4238/2014.July.24.7
   Lohrisch CA, 2011, J CLIN ONCOL, V29, DOI 10.1200/jco.2011.29.15_suppl.636
   Lustberg M. B., 2015, CANC RES, V75
   Mao JJ, 2009, INTEGR CANCER THER, V8, P123, DOI 10.1177/1534735409332903
   Mao JJ, 2014, CANCER-AM CANCER SOC, V120, P3744, DOI 10.1002/cncr.28917
   Mao JJ, 2009, CANCER, V115, P3631, DOI 10.1002/cncr.24419
   Massimino K, 2011, J CLIN ONCOL, V29, DOI 10.1200/jco.2011.29.27_suppl.170
   Menas Pamela, 2012, J Oncol Pharm Pract, V18, P387, DOI 10.1177/1078155211434853
   Miller WR, 2003, J STEROID BIOCHEM, V86, P413, DOI 10.1016/S0960-0760(03)00352-2
   Muslimani AA, 2009, CLIN BREAST CANCER, V9, P34, DOI 10.3816/CBC.2009.n.006
   Muss HB, 2008, J CLIN ONCOL, V26, P1956, DOI 10.1200/JCO.2007.12.6334
   Nyrop KA, 2014, J GERIATR ONCOL, V5, P148, DOI 10.1016/j.jgo.2013.12.002
   Oh B, 2013, ACUPUNCT MED, V31, P264, DOI 10.1136/acupmed-2012-010309
   Olivo SA, 2008, PHYS THER, V88, P156, DOI 10.2522/ptj.20070147
   Partridge AH, 2008, J CLIN ONCOL, V26, P556, DOI 10.1200/JCO.2007.11.5451
   Pavuluri MN, 2004, J AM ACAD CHILD PSY, V43, P528, DOI 10.1097/00004583-200405000-00006
   Presant CA, 2007, CLIN BREAST CANCER, V7, P775, DOI 10.3816/CBC.2007.n.038
   Prieto-Alhambra D, 2011, BREAST CANCER RES TR, V125, P869, DOI 10.1007/s10549-010-1075-9
   Rastelli AL, 2011, BREAST CANCER RES TR, V129, P107, DOI 10.1007/s10549-011-1644-6
   Regan MM, 2011, LANCET ONCOL, V12, P1101, DOI 10.1016/S1470-2045(11)70270-4
   Rosati MS, 2011, J CLIN ONCOL, V29, DOI 10.1200/jco.2011.29.15_suppl.533
   Santa-Maria CA, 2014, J CLIN ONCOL, V32, DOI 10.1200/jco.2014.32.15_suppl.9615
   Schwarzer G., 2016, METAL GEN PACKAGE ME
   Sestak I, 2009, J CLIN ONCOL, V27, P4961, DOI 10.1200/JCO.2009.22.0236
   Shapiro AC, 2016, BREAST CANCER RES TR, V155, P501, DOI 10.1007/s10549-016-3710-6
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Spathis A, 2014, J CLIN ONCOL, V32, P1882, DOI 10.1200/JCO.2013.54.4346
   The Cochrane Collaboration, 2011, COCHRANE HDB SYSTEMA
   Xepapadakis G, 2010, EJC SUPPL, V8, P164, DOI 10.1016/S1359-6349(10)70393-1
   Zhang QY, 2010, AM J CLIN ONCOL-CANC, V33, P557, DOI 10.1097/COC.0b013e3181cae782
NR 69
TC 51
Z9 62
U1 1
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1040-8428
EI 1879-0461
J9 CRIT REV ONCOL HEMAT
JI Crit. Rev. Oncol./Hematol.
PD MAR
PY 2017
VL 111
BP 66
EP 80
DI 10.1016/j.critrevonc.2017.01.010
PG 15
WC Oncology; Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Hematology
GA EO8RR
UT WOS:000396958100008
PM 28259297
DA 2026-01-16
ER

PT J
AU Tarrasch, R
   Carmel-Neiderman, NN
   Ben-Ami, S
   Kaufman, B
   Pfeffer, R
   Ben-David, M
   Gamus, D
AF Tarrasch, Ricardo
   Carmel-Neiderman, Narin N.
   Ben-Ami, Sarah
   Kaufman, Bella
   Pfeffer, Raphi
   Ben-David, Merav
   Gamus, Dorit
TI The Effect of Reflexology on the Pain-Insomnia-Fatigue Disturbance
   Cluster of Breast Cancer Patients During Adjuvant Radiation Therapy
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE reflexology; radiation therapy; fatigue; breast cancer
ID QUALITY-OF-LIFE; INTERVENTIONS; SURVIVORS; YOGA; COMPLEMENTARY;
   RADIOTHERAPY; ACUPUNCTURE; IMPACT
AB Objective: To evaluate the effects of reflexology treatment on quality of life, sleep disturbances, and fatigue in breast cancer patients during radiation therapy. Methods/Subjects: A total of 72 women with breast cancer (stages 1-3) scheduled for radiation therapy were recruited. Design: Women were allocated upon their preference either to the group receiving reflexology treatments once a week concurrently with radiotherapy and continued for 10 weeks or to the control group (usual care). Outcome measures: The Lee Fatigue Scale, General Sleep Disturbance Scale, and Multidimensional Quality of Life Scale Cancer were completed by each patient in both arms at the beginning of the radiation treatment, after 5 weeks, and after 10 weeks of reflexology treatment. Results: The final analysis included 58 women. The reflexology treated group demonstrated statistically significant lower levels of fatigue after 5 weeks of radiation therapy (p<0.001), compared to the control group. It was also detected that although the quality of life in the control group deteriorated after 5 and 10 weeks of radiation therapy (p<0.01 and p<0.05, respectively), it was preserved in the reflexology group, which also demonstrated a significant improvement in the quality of sleep after 10 weeks of radiation treatment (p<0.05). Similar patterns were obtained in the assessment of the pain levels experienced by the patients. Conclusions: The results of the present study indicate that reflexology may have a positive effect on fatigue, quality of sleep, pain, and quality of life in breast cancer patients during radiation therapy. Reflexology prevented the decline in quality of life and significantly ameliorated the fatigue and quality of sleep of these patients. An encouraging trend was also noted in amelioration of pain levels.
C1 [Tarrasch, Ricardo] Tel Aviv Univ, Jaime & Joan Constantiner Sch Educ, Tel Aviv, Israel.
   [Carmel-Neiderman, Narin N.; Gamus, Dorit] Sheba Med Ctr, Complementary & Integrat Med Serv, IL-52621 Ramat Gan, Israel.
   [Ben-Ami, Sarah; Kaufman, Bella] Sheba Med Ctr, Dept Oncol, Ramat Gan, Israel.
   [Pfeffer, Raphi; Ben-David, Merav] Sheba Med Ctr, Dept Radiat Oncol, Ramat Gan, Israel.
   [Ben-David, Merav] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
C3 Tel Aviv University; Chaim Sheba Medical Center; Tel Aviv University;
   Tel Aviv University; Chaim Sheba Medical Center; Chaim Sheba Medical
   Center; Tel Aviv University; Tel Aviv University; Sackler Faculty of
   Medicine
RP Gamus, D (corresponding author), Sheba Med Ctr, Complementary & Integrat Med Serv, IL-52621 Ramat Gan, Israel.
EM dorit.gamus@sheba.health.gov.il
RI Tarrasch, Ricardo/H-9197-2013
OI Tarrasch, Ricardo/0000-0003-1677-6615
CR Alcântara-Silva TRD, 2013, J CLIN NURS, V22, P2679, DOI 10.1111/jocn.12236
   Bower JE, 2014, NAT REV CLIN ONCOL, V11, P597, DOI 10.1038/nrclinonc.2014.127
   Bower JE, 2014, PSYCHONEUROENDOCRINO, V43, P20, DOI 10.1016/j.psyneuen.2014.01.019
   Bower JE, 2012, CANCER-AM CANCER SOC, V118, P3766, DOI 10.1002/cncr.26702
   Bower JE, 2009, CLIN CANCER RES, V15, P5534, DOI 10.1158/1078-0432.CCR-08-2584
   Carpenter J S, 1998, Issues Ment Health Nurs, V19, P481
   Chandwani KD, 2014, J CLIN ONCOL, V32, P1058, DOI 10.1200/JCO.2012.48.2752
   Cramp F, 2012, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD006145.PUB3
   Crane JD, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3002882
   De Sanctis V, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/523568
   Finnegan-John J, 2013, INTEGR CANCER THER, V12, P276, DOI 10.1177/1534735413485816
   Garrett K, 2011, J PAIN SYMPTOM MANAG, V42, P239, DOI 10.1016/j.jpainsymman.2010.11.010
   Gay Caryl L, 2004, Biol Res Nurs, V5, P311, DOI 10.1177/1099800403262142
   Gupta D, 2007, J PAIN SYMPTOM MANAG, V34, P40, DOI 10.1016/j.jpainsymman.2006.10.012
   Kapoor A, 2015, SOUTH ASIAN J CANCER, V4, P21, DOI 10.4103/2278-330X.149942
   Kiecolt-Glaser JK, 2014, J CLIN ONCOL, V32, P1040, DOI 10.1200/JCO.2013.51.8860
   Kutner JS, 2008, ANN INTERN MED, V149, P369, DOI 10.7326/0003-4819-149-6-200809160-00003
   Kwekkeboom KL, 2010, J PAIN SYMPTOM MANAG, V39, P126, DOI 10.1016/j.jpainsymman.2009.05.022
   LEE KA, 1992, BIRTH-ISS PERINAT C, V19, P208, DOI 10.1111/j.1523-536X.1992.tb00404.x
   LEE KA, 1991, PSYCHIAT RES, V36, P291, DOI 10.1016/0165-1781(91)90027-M
   Lee SH, 2015, INTEGR CANCER THER, V14, P297, DOI 10.1177/1534735415572885
   Matthews EE, 2012, CANCER NURS, V35, pE1, DOI 10.1097/NCC.0b013e3182277222
   Mishra SI, 2012, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD007566.pub2, 10.1002/14651858.CD008465.pub2]
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Montgomery GH, 2009, HEALTH PSYCHOL, V28, P317, DOI 10.1037/a0013582
   Moran MS, 2013, INT J RADIAT ONCOL, V85, P40, DOI 10.1016/j.ijrobp.2012.03.025
   Padilla G V, 1992, Qual Life Res, V1, P155, DOI 10.1007/BF00635615
   Paltiel O, 2001, J CLIN ONCOL, V19, P2439, DOI 10.1200/JCO.2001.19.9.2439
   Pan YQ, 2014, INT J CLIN ONCOL, V19, P829, DOI 10.1007/s10147-013-0635-5
   Pedersen CG, 2009, EUR J CANCER, V45, P3172, DOI 10.1016/j.ejca.2009.09.005
   Pud D, 2008, J PAIN SYMPTOM MANAG, V35, P162, DOI 10.1016/j.jpainsymman.2007.03.010
   Sharp DM, 2010, EUR J CANCER, V46, P312, DOI 10.1016/j.ejca.2009.10.006
   Siev-Ner I, 2003, MULT SCLER J, V9, P356, DOI 10.1191/1352458503ms925oa
   Yennurajalingam S, 2014, CANCER J, V20, P319, DOI 10.1097/PPO.0000000000000069
   Yu JS, 2013, INT REV NEUROBIOL, V111, P125, DOI 10.1016/B978-0-12-411545-3.00006-7
NR 35
TC 27
Z9 30
U1 1
U2 17
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD JAN
PY 2018
VL 24
IS 1
BP 62
EP 68
DI 10.1089/acm.2017.0023
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA FT1ZP
UT WOS:000422937900010
PM 28440664
DA 2026-01-16
ER

PT J
AU Lo, YJ
   Mishra, VK
   Lo, HY
   Dubey, NK
   Lo, WC
AF Lo, Yun-Jo
   Mishra, Viraj Krishna
   Lo, Hung-Yao
   Dubey, Navneet Kumar
   Lo, Wen-Cheng
TI Clinical Spectrum and Trajectory of Innovative Therapeutic Interventions
   for Insomnia: A Perspective
SO AGING AND DISEASE
LA English
DT Article
DE insomnia; cognitive behavioral therapy; whole-body cryotherapy;
   traditional chinese medicine; pulsed magnetic field therapy; acupressure
ID COGNITIVE-BEHAVIORAL THERAPY; WHOLE-BODY CRYOTHERAPY; MAJOR DEPRESSIVE
   DISORDER; SHORT-SLEEP DURATION; CRANIAL ELECTROTHERAPY STIMULATION;
   GENERALIZED ANXIETY DISORDER; OREXIN RECEPTOR ANTAGONISTS;
   MAGNETIC-FIELD THERAPY; CORTICAL GABA LEVELS; FATTY LIVER-DISEASE
AB Increasing incidences of insomnia in adults, as well as the aging population, have been reported for their negative impact on the quality of life. Insomnia episodes may be associated with neurocognitive, musculoskeletal, cardiovascular, gastrointestinal, renal, hepatic, and metabolic disorders. Epidemiological evidence also revealed the association of insomnia with oncologic and asthmatic complications, which has been indicated as bidirectional. Two therapeutic approaches including cognitive behavioral therapy (CBT) and drugs-based therapies are being practiced for a long time. However, the adverse events associated with drugs limit their wide and long-term application. Further, Traditional Chinese medicine, acupressure, and pulsed magnetic field therapy may also provide therapeutic relief. Notably, the recently introduced cryotherapy has been demonstrated as a potential candidate for insomnia which could reduce pain, by suppressing oxidative stress and inflammation. It seems that the synergistic therapeutic approach of cryotherapy and the above-mentioned approaches might offer promising prospects to further improve efficacy and safety. Considering these facts, this perspective presents a comprehensive summary of recent advances in pathological aetiologies of insomnia including COVID-19, and its therapeutic management with a greater emphasis on cryotherapy.
C1 [Lo, Yun-Jo; Lo, Hung-Yao] EUDA Wellness, Taipei 114, Taiwan.
   [Mishra, Viraj Krishna] Biosource Tech, Ambala 133101, Haryana, India.
   [Dubey, Navneet Kumar] Victory Biotechnol Co Ltd, Taipei 114757, Taiwan.
   [Dubey, Navneet Kumar] ShiNeo Technol Co Ltd, New Taipei 24262, Taiwan.
   [Lo, Wen-Cheng] Taipei Med Univ, Sch Med, Div Neurosurg, Dept Surg,Coll Med, Taipei 11031, Taiwan.
   [Lo, Wen-Cheng] Taipei Med Univ Hosp, Dept Neurosurg, Taipei 11031, Taiwan.
   [Lo, Wen-Cheng] Taipei Med Univ, Taipei Neurosci Inst, Taipei 11031, Taiwan.
C3 Taipei Medical University; Taipei Medical University Hospital; Taipei
   Medical University; Taipei Medical University
RP Dubey, NK (corresponding author), Victory Biotechnol Co Ltd, Taipei 114757, Taiwan.; Lo, WC (corresponding author), Taipei Med Univ, Sch Med, Div Neurosurg, Dept Surg,Coll Med, Taipei 11031, Taiwan.
EM nkd@victorybio.com.tw; drlons@h.tmu.edu.tw
RI Dubey, Navneet/H-3870-2019
CR Abdo SM, 2020, Physiotherapy Quarterly, V28, P30, DOI [10.5114/pq.2019.86462, 10.5114/pq.2019.86462, DOI 10.5114/PQ.2019.86462]
   Adamantidis AR, 2007, NATURE, V450, P420, DOI 10.1038/nature06310
   Adem K., 2020, Psychiatry journal, V2019, P2020, DOI 10.1155/2020/1402712
   Adie S, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007911.pub2
   Ahmed AE, 2017, ETHNIC HEALTH, V22, P285, DOI 10.1080/13557858.2016.1244624
   Akin YA., 2021, GULHANE TIP DERGISI, V63, P141
   Alfano CA, 2013, J AFFECT DISORDERS, V147, P379, DOI 10.1016/j.jad.2012.08.015
   Alimoradi Z, 2021, ECLINICALMEDICINE, V36, DOI 10.1016/j.eclinm.2021.100916
   Antza C, 2022, J ENDOCRINOL, V252, P125, DOI 10.1530/JOE-21-0155
   Archer SN, 2018, SLEEP MED REV, V40, P109, DOI 10.1016/j.smrv.2017.10.008
   Arnulf I, 2008, ARCH NEUROL-CHICAGO, V65, P482, DOI 10.1001/archneur.65.4.482
   Asarnow LD, 2019, SLEEP MED CLIN, V14, P177, DOI 10.1016/j.jsmc.2019.01.009
   Atas DB, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0248117
   Attele A S, 2000, Altern Med Rev, V5, P249
   Azizi Elnaz, 2022, Basic Clin Neurosci, V13, P519, DOI 10.32598/bcn.2022.2610.1
   Baglioni C, 2019, J SLEEP RES, P12967, DOI 10.1111/jsr.12967
   Baglioni C, 2011, J AFFECT DISORDERS, V135, P10, DOI 10.1016/j.jad.2011.01.011
   Baker FC, 2018, NAT SCI SLEEP, V10, P73, DOI 10.2147/NSS.S125807
   Bala MM, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009058.pub3
   Bamer AM, 2008, MULT SCLER J, V14, P1127, DOI 10.1177/1352458508092807
   Baranov A, 2019, LOW TEMPERATURE TECH
   Barbera J, 2005, DRUG SAFETY, V28, P301, DOI 10.2165/00002018-200528040-00003
   Barbosa GM, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-50958-8
   Barragan R, 2022, J CLIN MED, V11, DOI 10.3390/jcm11010076
   Bathgate CJ, 2017, SLEEP, V40, DOI 10.1093/sleep/zsw012
   Bathgate CJ, 2016, SLEEP, V39, P1037, DOI 10.5665/sleep.5748
   Baust JG, 2004, CRYOBIOLOGY, V48, P190, DOI 10.1016/j.cryobiol.2004.01.005
   Baylan S, 2020, SLEEP MED REV, V49, DOI 10.1016/j.smrv.2019.101222
   Beck F, 2013, REV NEUROL-FRANCE, V169, P956, DOI 10.1016/j.neurol.2013.02.011
   Bellesi M, 2017, J NEUROSCI, V37, P5263, DOI 10.1523/JNEUROSCI.3981-16.2017
   Benoliel R, 2009, J OROFAC PAIN, V23, P330
   Bernsmeier C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143293
   Bertisch SM, 2018, SLEEP, V41, DOI 10.1093/sleep/zsy047
   Besedovsky L, 2019, PHYSIOL REV, V99, P1325, DOI 10.1152/physrev.00010.2018
   Besedovsky L, 2012, PFLUG ARCH EUR J PHY, V463, P121, DOI 10.1007/s00424-011-1044-0
   Bhaskar Swapna, 2016, J Family Med Prim Care, V5, P780, DOI [10.4103/2249-4863.201153, 10.4103/2249-4863.201153]
   Bjoroy I, 2020, FRONT PSYCHOL, V11, DOI 10.3389/fpsyg.2020.00527
   Bjorvatn B, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.639198
   Bláfoss R, 2019, FRONT PUBLIC HEALTH, V7, DOI 10.3389/fpubh.2019.00117
   Blake J, 2021, MENOPAUSE, V28, P973, DOI 10.1097/GME.0000000000001831
   Blask DE, 2009, SLEEP MED REV, V13, P257, DOI 10.1016/j.smrv.2008.07.007
   Bonilla-Jaime H, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222212531
   Bonnet M H, 1997, Sleep Med Rev, V1, P97, DOI 10.1016/S1087-0792(97)90012-5
   Bouzigon R, 2016, J THERM BIOL, V61, P67, DOI 10.1016/j.jtherbio.2016.08.009
   Bragantini D, 2019, BMC MED GENET, V20, DOI 10.1186/s12881-019-0916-6
   Bragantini D, 2019, CHRONOBIOL INT, V36, P681, DOI 10.1080/07420528.2019.1582540
   Briançon-Marjollet A, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0018-3
   Brosseau L., 2003, COCHRANE DB SYST REV, pCD004259, DOI [DOI 10.1002/14651858.CD004522, 10.1002/14651858. CD004522]
   Bruno A, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17041176
   Brunyé TT, 2021, FRONT HUM NEUROSCI, V15, DOI 10.3389/fnhum.2021.625321
   Bruyneel M, 2018, NAT SCI SLEEP, V10, P369, DOI 10.2147/NSS.S186665
   Bryczkowska I, 2018, FAM MED PRIM CARE RE, V20, P214, DOI 10.5114/fmpcr.2018.78253
   Budhiraja R, 2011, SLEEP, V34, P859, DOI 10.5665/SLEEP.1114
   Butler AC, 2006, CLIN PSYCHOL REV, V26, P17, DOI 10.1016/j.cpr.2005.07.003
   Buysse DJ, 2008, SLEEP, V31, P473, DOI 10.1093/sleep/31.4.473
   Byrne EM, 2013, AM J MED GENET B, V162B, P439, DOI 10.1002/ajmg.b.32168
   Cai GH, 2018, SLEEP MED, V46, P81, DOI 10.1016/j.sleep.2018.03.009
   Callander GE, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00230
   Cao XL, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170772
   Cardinali DP, 2012, J PINEAL RES, V52, P365, DOI 10.1111/j.1600-079X.2011.00962.x
   Cauley JA, 2019, J BONE MINER RES, V34, P464, DOI 10.1002/jbmr.3619
   Chang M., 2020, RELATIONSHIP ANXIETY, V8, P6
   Cheng J, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.615854
   Cheng ZM, 2021, REV ECON HOUSEHOLD, V19, P123, DOI 10.1007/s11150-020-09538-3
   Chiao YW, 2021, FRONT NEUROL, V11, DOI 10.3389/fneur.2020.583485
   Chrusciak Tomasz, 2016, Reumatologia (Warsaw), V54, P291, DOI [10.5114/reum.2016.64904, 10.5114/reum.2016.64904]
   Chung KF, 2015, J CLIN PSYCHIAT, V76, pE752, DOI 10.4088/JCP.14m09124
   Chung S, 2020, PSYCHIAT INVEST, V17, P533, DOI 10.30773/pi.2019.0218
   Clark JW, 2020, SLEEP MED REV, V53, DOI 10.1016/j.smrv.2020.101332
   Clebak KT, 2020, AM FAM PHYSICIAN, V101, P399
   Collins NC, 2008, EMERG MED J, V25, P65, DOI 10.1136/emj.2007.051664
   [Colten A.B. Institute of Medicine (US) Committee on Sleep Medicine and Research Institute of Medicine (US) Committee on Sleep Medicine and Research], 2006, Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem
   Conley S, 2021, DIGEST DIS SCI, V66, P181, DOI 10.1007/s10620-020-06213-6
   Copinschi G, 2014, FRONT HORM RES, V42, P59, DOI 10.1159/000358858
   Cordes F, 2019, EUR HEART J-CASE REP, V3, DOI 10.1093/ehjcr/ytz221
   Cuijpers P, 2014, AM J PSYCHIAT, V171, P453, DOI 10.1176/appi.ajp.2013.13030325
   Dahl J, 2016, ACTA PSYCHIAT SCAND, V134, P40, DOI 10.1111/acps.12576
   Dantas LO, 2019, J PHYSIOTHER, V65, P215, DOI 10.1016/j.jphys.2019.08.004
   Freitas DCDV, 2013, REV ESC ENFERM USP, V47, P867, DOI 10.1590/S0080-623420130000400014
   Dhaliwal A, 2022, WORLD J GASTRO ENDOS, V14, P17, DOI 10.4253/wjge.v14.i1.17
   Dijk DJ, 2010, SLEEP MED REV, V14, P151, DOI 10.1016/j.smrv.2009.07.002
   Ding CZ, 2018, J OBES METAB SYNDR, V27, P4, DOI 10.7570/jomes.2018.27.1.4
   Ding M, 2018, PROG NEURO-PSYCHOPH, V86, P180, DOI 10.1016/j.pnpbp.2018.05.026
   Doets JJR, 2021, COMPLEMENT THER MED, V63, DOI 10.1016/j.ctim.2021.102783
   Dolsen MR, 2019, CURR PSYCHIAT REP, V21, DOI 10.1007/s11920-019-0993-4
   Dombrovski AY, 2008, DEPRESS ANXIETY, V25, P1060, DOI 10.1002/da.20467
   Dong Jia-Zi, 2018, Zhen Ci Yan Jiu, V43, P335, DOI 10.13702/j.1000-0607.171010
   Dong YJ, 2021, BIOMED PHARMACOTHER, V143, DOI 10.1016/j.biopha.2021.112141
   Dopheide JA, 2020, AM J MANAG CARE, V26, pS76, DOI [10.37765/ajmc.2020.42769, 10.37765/ajmc.2020.42769]
   Douzi Wafa, 2019, Eur J Sport Sci, V19, P860, DOI 10.1080/17461391.2018.1551937
   Douzi W, 2019, BMC RES NOTES, V12, DOI 10.1186/s13104-019-4172-9
   Du SQ, 2018, CNS NEUROSCI THER, V24, P39, DOI 10.1111/cns.12773
   Dubey AK, 2015, J PHARMACOL PHARMACO, V6, P118, DOI 10.4103/0976-500X.155496
   Dubey V, 2006, BIOMATERIALS, V27, P3491, DOI 10.1016/j.biomaterials.2006.01.060
   Dündar Y, 2004, HEALTH TECHNOL ASSES, V8, P1
   Dworak M, 2007, PEDIATRICS, V120, P978, DOI 10.1542/peds.2007-0476
   Dziadkowiak E, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22147370
   Edinger JD, 2013, SLEEP, V36, P1179, DOI 10.5665/sleep.2882
   Fang HF, 2015, J CANCER, V6, P1140, DOI 10.7150/jca.12490
   Fawzy RM, 2022, EGYPT RHEUMATOL REH, V49, DOI 10.1186/s43166-021-00108-8
   Ferini-Strambi L, 2017, PAIN THER, V6, pS19, DOI 10.1007/s40122-017-0089-y
   Fernandez-Mendoza J, 2021, SLEEP, V44, DOI 10.1093/sleep/zsaa150
   Fernandez-Mendoza J, 2020, SLEEP HEALTH, V6, P71, DOI 10.1016/j.sleh.2019.09.003
   Flo E, 2013, OCCUP ENVIRON MED, V70, P238, DOI 10.1136/oemed-2012-101091
   Ford ES, 2014, SLEEP, V37, P1283, DOI 10.5665/sleep.3914
   Formentin Chiara, 2018, Curr Hepatol Rep, V17, P52, DOI 10.1007/s11901-018-0390-1
   Fossum IN, 2014, BEHAV SLEEP MED, V12, P343, DOI 10.1080/15402002.2013.819468
   Fuggle NR, 2018, OSTEOPOROSIS INT, V29, P1581, DOI 10.1007/s00198-018-4503-z
   Garbarino S, 2021, COMMUN BIOL, V4, DOI 10.1038/s42003-021-02825-4
   Garcia C, 2021, PAIN THER, V10, P81, DOI 10.1007/s40122-020-00225-w
   Garland SN, 2019, JNCI-J NATL CANCER I, V111, P1323, DOI 10.1093/jnci/djz050
   Garland SN, 2018, MED HYPOTHESES, V120, P72, DOI 10.1016/j.mehy.2018.08.019
   Gasparro R, 2021, CANCERS, V13, DOI 10.3390/cancers13081855
   Gauthier S, 2006, LANCET, V367, P1262, DOI 10.1016/S0140-6736(06)68542-5
   Gazal M, 2013, PSYCHIAT RES, V209, P742, DOI 10.1016/j.psychres.2013.03.002
   George Mathew, 2015, Asian Pac J Cancer Prev, V16, P6711, DOI 10.7314/apjcp.2015.16.15.6711
   Giménez-Arnau A, 2013, EUR J DERMATOL, V23, P694, DOI 10.1684/ejd.2013.2099
   Godse Kiran Vasant, 2009, Indian J Dermatol, V54, P310, DOI 10.4103/0019-5154.57603
   Goforth HW, 2009, EXPERT OPIN PHARMACO, V10, P1649, DOI 10.1517/14656560903005587
   Goodman Anna O G, 2010, PLoS Curr, V2, pRRN1189, DOI 10.1371/currents.RRN1189
   Gooneratne NS, 2007, LUNG CANCER, V58, P403, DOI 10.1016/j.lungcan.2007.07.011
   Grandner MA, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-016-0805-8
   Grandner MA, 2015, SLEEP HEALTH, V1, P158, DOI 10.1016/j.sleh.2015.06.003
   Grandner MA, 2016, SLEEP MED, V18, P7, DOI 10.1016/j.sleep.2015.01.020
   Green MJ, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1268-4
   Grima M., 2017, MOL MECH SLEEP WAKE
   Grunder Wilfried, 2003, Z Med Phys, V13, P203
   Guillot X, 2017, JOINT BONE SPINE, V84, P477, DOI 10.1016/j.jbspin.2016.09.004
   Haack M, 2007, SLEEP, V30, P1145, DOI 10.1093/sleep/30.9.1145
   Hale L, 2015, SLEEP MED REV, V21, P50, DOI 10.1016/j.smrv.2014.07.007
   Haley H., ANXIETY DEPRESSION I
   Hammond L, 2020, J THERM BIOL, V91, DOI 10.1016/j.jtherbio.2020.102633
   Han QQ, 2021, J CANCER, V12, P7003, DOI 10.7150/jca.55803
   Hantsoo L, 2013, J PSYCHOSOM RES, V74, P283, DOI 10.1016/j.jpsychores.2013.01.014
   Hassan M, 2020, MIDDLE EAST CURR PSY, V27, DOI 10.1186/s43045-020-00030-3
   Haus EL, 2013, SLEEP MED REV, V17, P273, DOI 10.1016/j.smrv.2012.08.003
   Hawkins J., 2017, MED RES ARCH, V5
   Haynes J, 2018, SOUTH MED J, V111, P75, DOI 10.14423/SMJ.0000000000000769
   He Y., 2021, PHYS ACTIVITY HLTH, V5
   Heffner KL, 2018, CLIN J PAIN, V34, P1133, DOI 10.1097/AJP.0000000000000644
   Herzog-Krzywoszanska R, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00221
   Higuchi S, 2005, J SLEEP RES, V14, P267, DOI 10.1111/j.1365-2869.2005.00463.x
   Hirvonen H, 2017, RHEUMATOL INT, V37, P1481, DOI 10.1007/s00296-017-3771-9
   Hirvonen HE, 2006, CLIN EXP RHEUMATOL, V24, P295
   Hjetland GJ, 2021, FRONT PUBLIC HEALTH, V9, DOI 10.3389/fpubh.2021.794307
   Hofmann S.G., 2011, An introduction to modern CBT: Psychological solutions to mental health problems
   Hofmann SG, 2012, COGNITIVE THER RES, V36, P427, DOI 10.1007/s10608-012-9476-1
   Huo ZY, 2021, SLEEP MED, V87, P183, DOI 10.1016/j.sleep.2021.06.044
   Inutsuka Ayumu, 2013, Front Endocrinol (Lausanne), V4, P18, DOI 10.3389/fendo.2013.00018
   Inutsuka A, 2013, NAGOYA J MED SCI, V75, P29
   Irwin M, 2003, BRAIN BEHAV IMMUN, V17, P365, DOI 10.1016/S0889-1591(03)00031-X
   Irwin M, 1999, J CLIN ENDOCR METAB, V84, P1979, DOI 10.1210/jc.84.6.1979
   Irwin MR, 2019, NAT REV IMMUNOL, V19, P702, DOI 10.1038/s41577-019-0190-z
   Irwin MR, 2017, NEUROPSYCHOPHARMACOL, V42, P129, DOI 10.1038/npp.2016.148
   Irwin MR, 2015, BRAIN BEHAV IMMUN, V47, P86, DOI 10.1016/j.bbi.2014.09.017
   Irwin MR, 2015, ANNU REV PSYCHOL, V66, P143, DOI 10.1146/annurev-psych-010213-115205
   Jafari-koulaee A, 2020, COMPLEMENT THER MED, V49, DOI 10.1016/j.ctim.2020.102326
   Janson C, 2001, SLEEP, V24, P425, DOI 10.1093/sleep/24.4.425
   Jansson C, 2009, CLIN GASTROENTEROL H, V7, P960, DOI 10.1016/j.cgh.2009.03.007
   Jarrar MH, 2008, ALIMENT PHARM THER, V27, P412, DOI 10.1111/j.1365-2036.2007.03586.x
   Jehan S., 2018, SLEEP MED DISORD INT, V2, P127
   Jing RZ, 2021, SLEEP MED, V85, P66, DOI 10.1016/j.sleep.2021.06.034
   Johnson EO, 2006, J PSYCHIATR RES, V40, P700, DOI 10.1016/j.jpsychires.2006.07.008
   Kalmbach DA, 2020, SLEEP MED, V71, P151, DOI 10.1016/j.sleep.2019.11.1184
   Kalmbach DA, 2018, NAT SCI SLEEP, V10, P193, DOI 10.2147/NSS.S138823
   Kaminska M, 2011, J NEUROL SCI, V302, P7, DOI 10.1016/j.jns.2010.12.008
   Kandeger A, 2019, EAT WEIGHT DISORD-ST, V24, P47, DOI 10.1007/s40519-018-0518-x
   Kasmi S, 2020, APPL PSYCHOL-HLTH WE, V12, P259, DOI 10.1111/aphw.12183
   Kaur H., 2021, StatPearls Publishing
   Kavanagh J, 2018, CURR OPIN PULM MED, V24, P569, DOI 10.1097/MCP.0000000000000526
   Kavirajan HC, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010521.pub2
   Kéri S, 2014, BRAIN BEHAV IMMUN, V40, P235, DOI 10.1016/j.bbi.2014.03.020
   Khaled SM, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-020-03035-8
   Khan IW, 2018, SLEEP SCI, V11, P166, DOI 10.5935/1984-0063.20180031
   Khanijow Vikesh, 2015, Gastroenterol Hepatol (N Y), V11, P817
   Khurshid Khurshid A, 2018, Innov Clin Neurosci, V15, P28
   Kim DJ, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-01291-6
   Kim SH, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000026223
   Kirsch DL, 2013, PSYCHIAT CLIN N AM, V36, P169, DOI 10.1016/j.psc.2013.01.006
   Klemm P, 2021, ADV RHEUMATOL, V61
   Koffel EA, 2015, SLEEP MED REV, V19, P6, DOI 10.1016/j.smrv.2014.05.001
   Kroeger D, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-06590-7
   Krzystanek M., 2021, PHARM BASEL, V14
   Ksiezopolska-Orlowska K, 2016, DISABIL REHABIL, V38, P1034, DOI 10.3109/09638288.2015.1060265
   Kubrak T, 2022, MOLECULES, V27, DOI 10.3390/molecules27030731
   Kumar M, 2021, J CLIN EXP HEPATOL, V11, P453, DOI 10.1016/j.jceh.2020.10.006
   Kwon Dong Rak, 2019, Journal of sleep medicine, V16, P36, DOI [10.13078/jsm.19029, 10.13078/jsm.19029]
   Lai CC, 2021, CRIT REV ONCOL HEMAT, V160, DOI 10.1016/j.critrevonc.2021.103276
   Lallukka T, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-565
   Lande R Gregory, 2018, Prim Care Companion CNS Disord, V20, DOI [10.4088/pcc.17m02214, 10.4088/PCC.17m02214]
   Langin D, 2006, TRENDS ENDOCRIN MET, V17, P314, DOI 10.1016/j.tem.2006.08.003
   Lao XQ, 2018, J CLIN SLEEP MED, V14, P109, DOI 10.5664/jcsm.6894
   Lee CL, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-88739-x
   Lee JY, 2019, POL ARCH INTERN MED, V129, P839, DOI 10.20452/pamw.4391
   Lee MS, 2008, INT J CLIN PRACT, V62, P1744, DOI 10.1111/j.1742-1241.2008.01876.x
   Lee SH, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1220-z
   Leger D, 2000, J SLEEP RES, V9, P35, DOI 10.1046/j.1365-2869.2000.00178.x
   Léger D, 2010, SLEEP MED REV, V14, P379, DOI 10.1016/j.smrv.2010.01.003
   Legrand FD, 2020, COMPLEMENT THER MED, V55, DOI 10.1016/j.ctim.2020.102539
   Lemoine P, 2011, THER CLIN RISK MANAG, V7, P301, DOI 10.2147/TCRM.S23036
   Levenson JC, 2015, CHEST, V147, P1179, DOI 10.1378/chest.14-1617
   Li C, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00586
   Li FG, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/8034263
   Li J, 2019, ACUPUNCT MED, V37, P107, DOI 10.1177/0964528419828733
   Li LJ, 2018, STROKE VASC NEUROL, V3, P197, DOI 10.1136/svn-2017-000136
   Li SS, 2020, NAT SCI SLEEP, V12, P1201, DOI 10.2147/NSS.S282315
   Li SS, 2018, ACUPUNCT MED, V36, P295, DOI 10.1136/acupmed-2017-011530
   Li XM, 2009, CURR OPIN ALLERGY CL, V9, P161, DOI 10.1097/ACI.0b013e328329226f
   Li Y, 2015, HYPERTENSION, V65, P644, DOI 10.1161/HYPERTENSIONAHA.114.04604
   Liang L, 2019, SLEEP MED, V62, P6, DOI 10.1016/j.sleep.2019.03.016
   Lie Janette D, 2015, P T, V40, P759
   Lim MM, 2014, NEURODEGENER DIS MAN, V4, P351, DOI [10.2217/NMT.14.33, 10.2217/nmt.14.33]
   Lind MJ, 2016, BRAIN SCI, V6, DOI 10.3390/brainsci6040064
   Liu FG, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/6621993
   Lombardi F, 2020, J NEUROSCI, V40, P171, DOI 10.1523/JNEUROSCI.1278-19.2019
   Lopresti AL, 2017, AUST NZ J PSYCHIAT, V51, P565, DOI 10.1177/0004867417701996
   Lu JL, 2018, MAYO CLIN PROC, V93, P1563, DOI 10.1016/j.mayocp.2018.05.032
   Lucassen EA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176685
   Lucassen EA, 2012, ANN NY ACAD SCI, V1264, P110, DOI 10.1111/j.1749-6632.2012.06655.x
   Lufiyani I, 2019, ENFERM CLIN, V29, P331, DOI 10.1016/j.enfcli.2019.04.141
   Luyster FS, 2016, CHEST, V150, P1242, DOI 10.1016/j.chest.2016.09.020
   Madari S, 2021, NEUROTHERAPEUTICS, V18, P44, DOI 10.1007/s13311-021-01010-z
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P676, DOI 10.1016/j.pnpbp.2010.05.004
   Main LC, 2009, RES SPORTS MED, V17, P121, DOI 10.1080/15438620802689757
   Mallon Lena, 2014, Sleep Disord, V2014, P843126, DOI 10.1155/2014/843126
   Manecke G, 2011, PRINCIPLES AND PRACTICE OF ANESTHESIA FOR THORACIC SURGERY, P537, DOI 10.1007/978-1-4419-0184-2_38
   Månsson KNT, 2021, INT J COGN THER, V14, P182, DOI 10.1007/s41811-020-00089-0
   Marilena V, 2018, MELATONIN
   Martinez SA, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192451
   Maywood ES, 2010, J NEUROSCI, V30, P10199, DOI 10.1523/JNEUROSCI.1694-10.2010
   McAlpine CS, 2022, J EXP MED, V219, DOI 10.1084/jem.20220081
   McCurry SM, 2021, JAMA INTERN MED, V181, P530, DOI 10.1001/jamainternmed.2020.9049
   Melancon MO, 2014, PATHOL BIOL, V62, P276, DOI 10.1016/j.patbio.2014.07.004
   Mendes-Neto José Marden, 2020, BrJP, V3, P53, DOI [10.5935/2595-0118.20200012, 10.5935/2595-0118.20200012]
   Metz M, 2010, ANN ALLERG ASTHMA IM, V104, P86, DOI 10.1016/j.anai.2009.11.013
   Michelson D, 2014, LANCET NEUROL, V13, P461, DOI 10.1016/S1474-4422(14)70053-5
   Miller E, 2011, WORLD J BIOL PSYCHIA, V12, P223, DOI 10.3109/15622975.2010.518626
   Miller E, 2010, J THERM BIOL, V35, P406, DOI 10.1016/j.jtherbio.2010.08.006
   Miller Elzbieta, 2010, Wiad Lek, V63, P41
   Mirza-Aghazadeh-Attari M, 2022, CANCER CELL INT, V22, DOI 10.1186/s12935-022-02472-7
   Mitchell LJ, 2019, SLEEP MED REV, V47, P90, DOI 10.1016/j.smrv.2019.06.002
   Mitchell MD, 2012, BMC FAM PRACT, V13, DOI 10.1186/1471-2296-13-40
   Moberg LT, 2021, J EAT DISORD, V9, DOI 10.1186/s40337-021-00430-8
   Moderie C, 2021, SLEEP DISORDERS PATI
   Monti JM, 2000, SLEEP MED REV, V4, P263, DOI 10.1053/smrv.1999.0096
   Moore RY, 2007, SLEEP MED, V8, pS27, DOI 10.1016/j.sleep.2007.10.003
   Moreira FP, 2015, J NEUROIMMUNOL, V285, P143, DOI 10.1016/j.jneuroim.2015.06.004
   Morey SS, 1998, AM FAM PHYSICIAN, V57, P2545
   Morgan PT, 2012, SLEEP, V35, P807, DOI 10.5665/sleep.1880
   Morin CM, 2021, SLEEP MED, V77, P346, DOI 10.1016/j.sleep.2020.06.005
   Morin CM, 2012, LANCET, V379, P1129, DOI 10.1016/S0140-6736(11)60750-2
   Morin CM, 2006, SLEEP MED, V7, P123, DOI 10.1016/j.sleep.2005.08.008
   Morin CM, 2004, J CLIN PSYCHIAT, V65, P33
   Morphy H, 2007, SLEEP, V30, P274
   Moylan S, 2013, MOL PSYCHIATR, V18, P595, DOI 10.1038/mp.2012.33
   Murtagh KN, 2004, AM J PUBLIC HEALTH, V94, P1406, DOI 10.2105/AJPH.94.8.1406
   Nam HW, 2012, ALCOHOL CLIN EXP RES, V36, P1117, DOI 10.1111/j.1530-0277.2011.01722.x
   Neutel D, 2015, SLEEP MED, V16, P754, DOI 10.1016/j.sleep.2014.12.021
   Neves G. S. L., 2016, Revista Brasileira de Neurologia, V51
   Ni XJ, 2019, J ALTERN COMPLEM MED, V25, P8, DOI 10.1089/acm.2018.0249
   Ni XJ, 2015, SLEEP MED, V16, P1462, DOI 10.1016/j.sleep.2015.08.012
   Nofzinger EA, 2004, AM J PSYCHIAT, V161, P2126, DOI 10.1176/appi.ajp.161.11.2126
   Norman JL, 2016, NAT SCI SLEEP, V8, P239, DOI 10.2147/NSS.S76910
   Ochs-Balcom HM, 2020, J BONE MINER RES, V35, P261, DOI 10.1002/jbmr.3879
   Ohayon MM, 2019, SLEEP MED REV, V47, P28, DOI 10.1016/j.smrv.2019.06.001
   Ohayon MM, 2010, SLEEP MED, V11, P980, DOI 10.1016/j.sleep.2010.07.012
   Ohayon MM, 2002, SLEEP MED, V3, P115, DOI 10.1016/S1389-9457(01)00158-7
   Ohayon MM, 2002, ENCEPHALE, V28, P420
   Macêdo PJOM, 2017, EPILEPSY RES, V135, P158, DOI 10.1016/j.eplepsyres.2017.05.014
   Oroz R, 2021, SLEEP SCI PRACT, V5, P3
   Orr WC, 2020, LANCET GASTROENTEROL, V5, P616, DOI 10.1016/S2468-1253(19)30412-1
   Palagini L, 2018, J CLIN SLEEP MED, V14, P759, DOI 10.5664/jcsm.7100
   Palagini L, 2014, SLEEP MED REV, V18, P225, DOI 10.1016/j.smrv.2013.05.002
   Palesh O, 2018, BRIT J CANCER, V119, P274, DOI 10.1038/s41416-018-0154-2
   Panda S, 2012, NEUROL INDIA, V60, P68, DOI 10.4103/0028-3886.93601
   Park HJ, 2011, CELL MOL NEUROBIOL, V31, P1123, DOI 10.1007/s10571-011-9718-x
   Park J, 2012, ACUPUNCT MED, V30, P195, DOI 10.1136/acupmed-2012-010144
   Park S, 2020, SLEEP MED, V71, P1, DOI 10.1016/j.sleep.2020.02.018
   Pasche B., 2004, BIOELECTROMAGNETIC M, P324
   Patel D, 2018, J CLIN SLEEP MED, V14, P1017, DOI 10.5664/jcsm.7172
   Pavloya MK, 2019, NAT SCI SLEEP, V11, P189, DOI 10.2147/NSS.S198944
   Pelka RB, 2001, ADV THER, V18, P101, DOI 10.1007/BF02850298
   Pelka RB, 2001, ADV THER, V18, P174, DOI 10.1007/BF02850111
   Perlis M L., 2013, Encyclopedia of Sleep; 2013, P199
   Perlis ML, 1997, J SLEEP RES, V6, P179, DOI 10.1046/j.1365-2869.1997.00045.x
   Pétein C, 2021, THER ADV PSYCHOPHARM, V11, DOI 10.1177/20451253211011874
   Petersén Å, 2012, J HUNTINGTONS DIS, V1, P5, DOI 10.3233/JHD-2012-120006
   Pigeon WR, 2008, SLEEP, V31, P481, DOI 10.1093/sleep/31.4.481
   Pillai V, 2017, SLEEP, V40, DOI 10.1093/sleep/zsw044
   Pini L, 2020, HUM BRAIN MAPP, V41, P256, DOI 10.1002/hbm.24790
   Planas-Ballvé A, 2022, NEUROLOGIA, V37, P639, DOI [10.1016/j.nrleng.2019.07.008, 10.1016/j.nrl.2019.07.006]
   Plante DT, 2012, SLEEP, V35, P741, DOI 10.5665/sleep.1854
   Plotogea OM, 2021, J PERS MED, V11, DOI 10.3390/jpm11121387
   Politis M, 2008, BRAIN, V131, P2860, DOI 10.1093/brain/awn244
   Porkka-Heiskanen T, 1997, SCIENCE, V276, P1265, DOI 10.1126/science.276.5316.1265
   Porramezani N, 2019, Journal of Advances in Medical and Biomedical Research, V27, P37, DOI 10.30699/jambs.27.124.37
   Portas CM, 2000, PROG NEUROBIOL, V60, P13, DOI 10.1016/S0301-0082(98)00097-5
   Prather AA, 2009, BIOL PSYCHOL, V82, P12, DOI 10.1016/j.biopsycho.2009.04.008
   Qi ZZ, 2021, PHARMACEUTICS, V13, DOI 10.3390/pharmaceutics13122198
   Quartana PJ, 2015, BRAIN BEHAV IMMUN, V47, P228, DOI 10.1016/j.bbi.2014.12.010
   Quigg M, 2016, EPILEPSY RES, V122, P91, DOI 10.1016/j.eplepsyres.2016.02.014
   Reddy M S, 2011, Indian J Psychol Med, V33, P1, DOI 10.4103/0253-7176.85388
   Redfern RE, 2018, J PEDIATR NURS, V38, P1, DOI 10.1016/j.pedn.2017.09.009
   Ren CY, 2021, SLEEP MED, V81, P42, DOI 10.1016/j.sleep.2021.02.005
   Ren R, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01672-5
   Reutrakul S, 2018, METABOLISM, V84, P56, DOI 10.1016/j.metabol.2018.02.010
   Riemann D, 2010, SLEEP MED REV, V14, P19, DOI 10.1016/j.smrv.2009.04.002
   Rivera J, 2018, RHEUMATOL INT, V38, P2243, DOI 10.1007/s00296-018-4176-0
   Roach M, 2021, INT J NEUROSCI, V131, P1058, DOI 10.1080/00207454.2020.1773460
   Robertson ME, 2016, SPRINGERPLUS, V5, DOI 10.1186/s40064-016-2578-6
   Rogers NL, 2003, SLEEP, V26, P1058
   Rose KM, 2009, APPL NURS RES, V22, P119, DOI 10.1016/j.apnr.2007.06.001
   Rossman J, 2019, AM J LIFESTYLE MED, V13, P544, DOI 10.1177/1559827619867677
   Roth T, 2010, CURR MED RES OPIN, V26, P2411, DOI 10.1185/03007995.2010.516142
   Roth T, 2009, AM J MANAG CARE, V15, pS6
   Roy S. K., 2015, International Journal of Medicine and Public Health, V5, P293
   Royant-Parola S, 2018, ENCEPHALE, V44, P321, DOI 10.1016/j.encep.2017.03.009
   Rymaszewska J, 2008, ARCH IMMUNOL THER EX, V56, P63, DOI 10.1007/s00005-008-0006-5
   Rymaszewska J, 2021, EXP GERONTOL, V146, DOI 10.1016/j.exger.2021.111237
   Rymaszewska J, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00522
   Rymaszewska J, 2019, PSYCHIATR POL, V53, P1053, DOI 10.12740/PP/OnlineFirst/91298
   Rymaszewska J, 2018, CRYOLETTERS, V39, P190
   Rymaszewska J, 2008, ARCH PSYCHIATR PSYCH, V10, P49
   Sadura-Sieklucka Teresa, 2019, Reumatologia (Warsaw), V57, P320, DOI [10.5114/reum.2019.90825, 10.5114/reum.2019.90825]
   Sakurai T, 2005, NEURON, V46, P297, DOI 10.1016/j.neuron.2005.03.010
   Santos LF, 2018, EUR J PHARM SCI, V118, P49, DOI 10.1016/j.ejps.2018.03.020
   Santoso AMM, 2019, SLEEP MED REV, V47, P62, DOI 10.1016/j.smrv.2019.06.003
   Saper CB, 2005, NATURE, V437, P1257, DOI 10.1038/nature04284
   Saponaro C, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0607-4
   Sasaki S, 2018, SLEEP BREATH, V22, P257, DOI 10.1007/s11325-017-1508-3
   Sauer LA, 2007, J NUTR BIOCHEM, V18, P637, DOI 10.1016/j.jnutbio.2006.12.009
   Sauvet F, 2010, J APPL PHYSIOL, V108, P68, DOI 10.1152/japplphysiol.00851.2009
   Savard J, 2003, PSYCHOSOM MED, V65, P211, DOI 10.1097/01.PSY.0000033126.22740.F3
   Schmitt K, 2016, ANN MED, V48, P42, DOI 10.3109/07853890.2015.1131327
   Schutte-Rodin S, 2008, J CLIN SLEEP MED, V4, P487
   Seixas AA, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011939
   Senczyszyn A, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.649066
   Shi TT, 2020, J SLEEP RES, V29, DOI 10.1111/jsr.12876
   Shiao YC, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-99410-w
   Shoji S., 2009, JPN J CLIN MED, V67, P1525
   Sieron A, 2007, REHABIL PRAKTYCE, V3, P34
   Sieron A, 2007, KRIOTERAPIA LECZENIE, V15, P149
   Silva Adriana Lucia Pastore, 2007, Acta ortop. bras., V15, P204
   Singh A, 2017, INT REV NEUROBIOL, V135, P97, DOI 10.1016/bs.irn.2017.02.006
   Sivertsen B, 2012, PSYCHOSOM MED, V74, P758, DOI 10.1097/PSY.0b013e3182648619
   Slade AN, 2020, SUPPORT CARE CANCER, V28, P551, DOI 10.1007/s00520-019-04849-3
   Smith LL, 2000, MED SCI SPORT EXER, V32, P317, DOI 10.1097/00005768-200002000-00011
   Soehner AM, 2014, J AFFECT DISORDERS, V167, P93, DOI 10.1016/j.jad.2014.05.060
   Sofi F, 2014, EUR J PREV CARDIOL, V21, P57, DOI 10.1177/2047487312460020
   Spence DW, 2004, J NEUROPSYCH CLIN N, V16, P19, DOI 10.1176/appi.neuropsych.16.1.19
   Spiegel K, 2004, J CLIN ENDOCR METAB, V89, P5762, DOI 10.1210/jc.2004-1003
   Spiegel K, 2011, J CLIN ENDOCR METAB, V96, P486, DOI 10.1210/jc.2010-1978
   Stahl SM, 2009, CNS SPECTRUMS, V14, P536, DOI 10.1017/S1092852900024020
   Stanczykiewicz B, 2015, EUR PSYCHIAT, V30, DOI 10.1016/S0924-9338(15)31127-5
   Stanek A., 2005, BALNEOL POL, V47, P24
   Stanek A, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121308
   Stanek A, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/7524878
   Stanek A, 2018, MEDIAT INFLAMM, V2018, DOI 10.1155/2018/8592532
   Stanek A, 2016, ADV CLIN EXP MED, V25, P1281, DOI 10.17219/acem/65980
   Stanek A, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/404259
   Stanhope BA, 2020, CURR BIOL, V30, P1092, DOI 10.1016/j.cub.2020.02.057
   Su Y, 2017, OSTEOPOROSIS INT, V28, P151, DOI 10.1007/s00198-016-3785-2
   Sumowski JF, 2021, ANN CLIN TRANSL NEUR, V8, P1172, DOI 10.1002/acn3.51262
   Sun HZ, 2020, BIOSCIENCE REP, V40, DOI 10.1042/BSR20201084
   Suszko R., 2003, MED REHABIL, V7, P63
   Swanson CM, 2018, METABOLISM, V84, P28, DOI 10.1016/j.metabol.2017.12.002
   Tachikawa M, 2012, J PHARMACOL EXP THER, V343, P608, DOI 10.1124/jpet.112.197012
   Tahmasian M, 2020, COMMUN BIOL, V3, DOI 10.1038/s42003-020-0892-6
   Tan DX, 2016, MED HYPOTHESES, V86, P3, DOI 10.1016/j.mehy.2015.11.018
   Tang HT, 2018, CHIN MED-UK, V13, DOI 10.1186/s13020-018-0165-1
   Tang JS, 2017, SCI REP-UK, V7, DOI 10.1038/srep43690
   Tang WK, 2015, TOP STROKE REHABIL, V22, P201, DOI 10.1179/1074935714Z.0000000026
   Tang YC, 2021, ARCH OSTEOPOROS, V16, DOI 10.1007/s11657-021-01025-1
   Taylor DJ, 2010, J AFFECT DISORDERS, V123, P181, DOI 10.1016/j.jad.2009.08.007
   Taylor-Gjevre RM, 2011, MUSCULOSKELET CARE, V9, P152, DOI 10.1002/msc.208
   Thakkar MM, 2011, SLEEP MED REV, V15, P65, DOI 10.1016/j.smrv.2010.06.004
   Toi N, 2019, J CLIN TRANSL ENDOCR, V15, P37, DOI 10.1016/j.jcte.2018.12.006
   Tsai Wen-Hsin, 2013, J Tradit Complement Med, V3, P142, DOI 10.4103/2225-4110.114898
   Tsega SS, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0261386
   Um YH, 2022, SLEEP BREATH, V26, P865, DOI 10.1007/s11325-021-02459-0
   Urade Y, 2010, FUTUR NEUROL, V5, P363, DOI 10.2217/FNL.10.18
   Ursin R, 2002, SLEEP MED REV, V6, P57, DOI 10.1053/smrv.2001.0174
   Valero-Cabré A, 2017, NEUROSCI BIOBEHAV R, V83, P381, DOI 10.1016/j.neubiorev.2017.10.006
   Van den Bulck J, 2004, SLEEP, V27, P101, DOI 10.1093/sleep/27.1.101
   van der Zweerde T, 2019, SLEEP MED REV, V48, DOI 10.1016/j.smrv.2019.08.002
   van Leeuwen WMA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004589
   Vasey C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103480
   Vashadze Sh V, 2007, Georgian Med News, P22
   Vendrame M, 2013, J CLIN SLEEP MED, V9, P141, DOI 10.5664/jcsm.2410
   Venner A, 2019, CURR BIOL, V29, P4155, DOI 10.1016/j.cub.2019.10.026
   Vgontzas AN, 2013, SLEEP MED REV, V17, P241, DOI 10.1016/j.smrv.2012.09.005
   Vgontzas AN, 2012, SLEEP, V35, P61, DOI 10.5665/sleep.1586
   Vgontzas AN, 2009, DIABETES CARE, V32, P1980, DOI 10.2337/dc09-0284
   Vgontzas AN, 2009, SLEEP, V32, P491, DOI 10.1093/sleep/32.4.491
   Vinik A, 2010, J CLIN ENDOCR METAB, V95, P4802, DOI 10.1210/jc.2010-0892
   Vitiello MV, 2009, J CLIN SLEEP MED, V5, P355
   Voysey Z, 2021, J NEUROL, V268, P2275, DOI 10.1007/s00415-020-10334-3
   Wade AG, 2011, NEUROPSYCH DIS TREAT, V7, P1, DOI 10.2147/NDT.S15123
   Walsh JK, 2011, SLEEP, V34, P997, DOI 10.5665/SLEEP.1150
   Wang XY, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000022462
   Wiecek M, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11071041
   Wijarnpreecha K, 2017, J POSTGRAD MED, V63, P226, DOI 10.4103/jpgm.JPGM_140_17
   Wijarnpreecha K, 2016, QJM-INT J MED, V109, P461, DOI 10.1093/qjmed/hcv172
   Wojtecka-Lukasik E, 2010, INFLAMM RES, V59, P253, DOI 10.1007/s00011-009-0144-1
   Wright B, 2020, J SMALL ANIM PRACT, V61, P267, DOI 10.1111/jsap.13130
   Wuyts J, 2012, INT J PSYCHOPHYSIOL, V83, P8, DOI 10.1016/j.ijpsycho.2011.09.016
   Xie CL, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-18
   Xie YP, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021598
   Xu HC, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/8961748
   Yan B, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.016201
   Yennurajalingam S, 2018, J PAIN SYMPTOM MANAG, V55, P198, DOI 10.1016/j.jpainsymman.2017.08.027
   Yeung WF, 2021, NAT SCI SLEEP, V13, P1195, DOI 10.2147/NSS.S318874
   Yeung WF, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/902578
   Yi Sun Shin, 2018, J Menopausal Med, V24, P143, DOI [10.6118/jmm.2018.24.3.143, 10.6118/jmm.2018.24.3.143]
   You Wei, 2010, Zhen Ci Yan Jiu, V35, P261
   Yu P, 2022, CHEM ENG J, V430, DOI 10.1016/j.cej.2021.132633
   Yun Seokho, 2021, Yeungnam Univ J Med, V38, P267, DOI [10.12701/yujm.2021.01424, 10.12701/yujm.2021.01424]
   Zachariae R, 2018, JNCI-J NATL CANCER I, V110, P880, DOI 10.1093/jnci/djx293
   Zeng LN, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.577429
   Zhang LX, 2020, PSYCHOL HEALTH MED, V25, P1201, DOI 10.1080/13548506.2020.1738015
   Zhang MM, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000017842
   Zhang P, 2020, NAT SCI SLEEP, V12, P693, DOI 10.2147/NSS.S263528
   Zhao J, 2021, SLEEP MED, V81, P375, DOI 10.1016/j.sleep.2021.03.005
   Zhao J, 2021, PEERJ, V9, DOI 10.7717/peerj.10956
   Zhao KC, 2013, INT REV NEUROBIOL, V111, P217, DOI 10.1016/B978-0-12-411545-3.00011-0
   ZHENG S., 2021, CHINESE J PRACTICAL, P103
   Zheng W, 2019, IEEE T APPL SUPERCON, V29, DOI 10.1109/TASC.2018.2882069
   Zhou L, 2014, CRYOBIOLOGY, V68, P79, DOI 10.1016/j.cryobiol.2013.12.004
   Zhou RR, 2021, AGING-US, V13, P25153, DOI 10.18632/aging.203733
   Zhou Yan-Li, 2012, Zhen Ci Yan Jiu, V37, P302
   Ziemann E, 2012, J ATHL TRAINING, V47, P664, DOI 10.4085/1062-6050-47.6.13
   Zisapel N, 2007, CELL MOL LIFE SCI, V64, P1174, DOI 10.1007/s00018-007-6529-9
NR 432
TC 7
Z9 8
U1 2
U2 29
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD JUL 31
PY 2023
VL 14
IS 4
BP 1038
EP 1069
DI 10.14336/AD.2022.1203
EA DEC 2022
PG 32
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA X9ZS5
UT WOS:000894246900001
PM 37163444
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Weilert, F
AF Weilert, Frank
TI Prospective evaluation of simplified algorithm for EUS-guided
   intra-hepatic biliary access and anterograde interventions for failed
   ERCP
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Pancreato Bilio; Cancer; Therapeutic; Palliation; Endoscopy; Endoscopic
   retrograde cholangiopancreatography (ERCP); Endoscopic ultrasound (EUS)
ID PANCREATIC-DUCT DRAINAGE; OBSTRUCTION; CHOLANGIOPANCREATOGRAPHY;
   EXPERIENCE; VIDEOS
AB EUS-guided biliary drainage (EUS-BD) is technically challenging but alternative method of therapeutic intervention when ERCP fails.
   Assess the feasibility, safety and risks of EUS-BD with intra-hepatic biliary access and anterograde interventions using an algorithm to increase flexibility of interventions, limit adverse events and improve procedural time.
   Prospective observational cohort study.
   21 consecutive patients underwent EUS-BD drainage for failed ERCP.
   Technical and clinical success rates with adverse event rate using simplified algorithm.
   Patient recruitment from June 2011-October 2013; mean age of 67.4 years, predominantly male (70.5 %) with pancreatic cancer (52.4 %), cholangiocarcinoma (14.3 %), other malignant biliary obstruction (9.5 %) and benign biliary obstruction (23.8 %). Prior interventions included failed ERCP in 18/21 (85.7 %) while 3/21 (14.3 %) had primary EUS-BD. Anterograde cholangiogram was achieved in all patients. Technical success was achieved in 20/21 (95.2 %) with clinical success was achieved in 19/21 (90.4 %). Placement of access wire was across the ampulla in 10/20 (50 %) and into CBD or contra-lateral IHD in 10/20 (50 %). Tract dilatation was accomplished in 17/20 (85 %) but required completion using intra-hepatic needle knife in 3/20 (15 %). Anterograde interventions were performed in 16/20 (80 %) but crossover to rendezvous in 3/20 (15 %) or choledochoduodenostomy 1/20 (5 %). Three patients 3/21 (14.3 %) also had endoscopic duodenal SEMS placement to relieve duodenal obstruction. Two patients (9.5 %) had post-procedural bile leak and pain.
   EUS-guided anterograde biliary drainage using the intra-hepatic access route has high technical and clinical success with low adverse rate. We would promote a simplified standardized algorithm, which gives flexibility of direct anterograde interventions.
C1 Waikato Hosp, Dept Gastroenterol, Hamilton 3200, New Zealand.
C3 Waikato Hospital
RP Weilert, F (corresponding author), Waikato Hosp, Dept Gastroenterol, Pembroke St, Hamilton 3200, New Zealand.
EM frank.weilert@waikatodhb.health.nz
CR Burmester E, 2003, GASTROINTEST ENDOSC, V57, P246, DOI 10.1067/mge.2003.85
   Dhir V, 2012, GASTROINTEST ENDOSC, V75, P354, DOI 10.1016/j.gie.2011.07.075
   Giovannini M, 2003, ENDOSCOPY, V35, P1076, DOI 10.1055/s-2003-44596
   Khashab MA, 2013, GASTROINTEST ENDOSC, V78, P734, DOI 10.1016/j.gie.2013.05.013
   Maranki J, 2009, ENDOSCOPY, V41, P532, DOI 10.1055/s-0029-1214712
   Nguyen-Tang T, 2010, ENDOSCOPY, V42, P232, DOI 10.1055/s-0029-1243858
   Park DH, 2013, GASTROINTEST ENDOSC, V78, P91, DOI 10.1016/j.gie.2013.01.042
   Park DH, 2012, GASTROINTEST ENDOSC, V75, P692, DOI 10.1016/j.gie.2011.04.013
   Park DH, 2011, GASTROINTEST ENDOSC, V74, P1276, DOI 10.1016/j.gie.2011.07.054
   Püspök A, 2005, AM J GASTROENTEROL, V100, P1743, DOI 10.1111/j.1572-0241.2005.41806.x
   Shah Janak N, 2005, Gastrointest Endosc Clin N Am, V15, P513, DOI 10.1016/j.giec.2005.03.003
   Shah JN, 2012, GASTROINTEST ENDOSC, V75, P56, DOI 10.1016/j.gie.2011.08.032
   SMITH AC, 1994, LANCET, V344, P1655, DOI 10.1016/S0140-6736(94)90455-3
   Stoker J, 1993, J Vasc Interv Radiol, V4, P767, DOI 10.1016/S1051-0443(93)71970-3
   Tapping CR, 2011, EUR RADIOL, V21, P1948, DOI 10.1007/s00330-011-2121-7
   Vila JJ, 2012, GASTROINTEST ENDOSC, V76, P1133, DOI 10.1016/j.gie.2012.08.001
   Wiersema MJ, 1996, GASTROINTEST ENDOSC, V43, P102, DOI 10.1016/S0016-5107(06)80108-2
   Will U, 2005, ENDOSCOPY, V37, P171, DOI 10.1055/s-2004-826151
   Winick A B, 2001, Tech Vasc Interv Radiol, V4, P200, DOI 10.1016/S1089-2516(01)90026-5
NR 19
TC 19
Z9 22
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD NOV
PY 2014
VL 28
IS 11
BP 3193
EP 3199
DI 10.1007/s00464-014-3588-5
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AS3HL
UT WOS:000344168200022
PM 24879144
DA 2026-01-16
ER

PT J
AU Liedtke, W
AF Liedtke, Wolfgang
TI Long March Toward Safe and Effective Analgesia by Enhancing Gene
   Expression of Kcc2: First Steps Taken
SO FRONTIERS IN MOLECULAR NEUROSCIENCE
LA English
DT Review
DE pain; spinal cord dorsal horn; KCC2; Kcc2 gene expression enhancer;
   GSK3; delta-catenin; Kaiso
ID CATION-CHLORIDE-COTRANSPORTERS; NMDA RECEPTOR-ACTIVITY; NEUROPATHIC
   PAIN; DEVELOPMENTAL SWITCH; SYNAPTIC INHIBITION; DOWN-REGULATION; ANION
   GRADIENT; MOTOR-NEURONS; UP-REGULATION; NERVE
AB Low intraneuronal chloride in spinal cord dorsal horn pain relay neurons is critical for physiologic transmission of primary pain afferents because low intraneuronal chloride dictates whether GABA-ergic and glycin-ergic neurotransmission is inhibitory. If the neuronal chloride elevates to pathologic levels, then spinal cord primary pain relay becomes leaky and exhibits the behavioral hallmarks of pathologic pain, namely hypersensitivity and allodynia. Low chloride in spinal cord dorsal horn neurons is maintained by proper gene expression of Kcc2 and sustained physiologic function of the KCC2 chloride extruding electroneutral transporter. Peripheral nerve injury and other forms of neural injury evoke greatly diminished Kcc2 gene expression and subsequent corruption of inhibitory neurotransmission in the spinal cord dorsal horn, thus causing derailment of the gate function for pain. Here I review key discoveries that have helped us understand these fundamentals, and focus on recent insights relating to the discovery of Kcc2 gene expression enhancing compounds via compound screens in neurons. One such study characterized the kinase inhibitor, kenpaullone, more in-depth, revealing its function as a robust and long-lasting analgesic in preclinical models of nerve injury and cancer bone pain, also elucidating its mechanism of action via GSK3 beta inhibition, diminishing delta-catenin phosphorylation, and facilitating its nuclear transfer and subsequent enhancement of Kcc2 gene expression by de-repressing Kaiso epigenetic transcriptional regulator. Future directions re Kcc2 gene expression enhancement are discussed, namely combination with other analgesics and analgesic methods, such as spinal cord stimulation and electroacupuncture, gene therapy, and leveraging Kcc2 gene expression-enhancing nanomaterials.
C1 [Liedtke, Wolfgang] Regeneron Pharmaceut, Global Dev Sci Council, Tarrytown, NY 10591 USA.
C3 Regeneron
RP Liedtke, W (corresponding author), Regeneron Pharmaceut, Global Dev Sci Council, Tarrytown, NY 10591 USA.
EM wolfgang.liedtke@regeneron.com
RI Liedtke, Wolfgang/GNH-1878-2022
CR Austin TM, 2011, ANESTH ANALG, V113, P1509, DOI 10.1213/ANE.0b013e31822e0a5d
   Ben-Ari Y, 2012, NEUROSCIENTIST, V18, P467, DOI 10.1177/1073858412438697
   Berta T, 2017, EXPERT OPIN THER TAR, V21, P695, DOI 10.1080/14728222.2017.1328057
   Castro A, 2017, PAIN, V158, P1366, DOI 10.1097/j.pain.0000000000000926
   Chamessian A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25110-7
   Côme E, 2020, NEUROPHARMACOLOGY, V169, DOI 10.1016/j.neuropharm.2019.03.014
   Cook C, 2018, ADV EMERG NURS J, V40, P148, DOI 10.1097/TME.0000000000000203
   Coull JAM, 2005, NATURE, V438, P1017, DOI 10.1038/nature04223
   Coull JAM, 2003, NATURE, V424, P938, DOI 10.1038/nature01868
   Dai SD, 2011, CANCER SCI, V102, P95, DOI 10.1111/j.1349-7006.2010.01766.x
   Dedek A, 2019, BRAIN, V142, P1535, DOI 10.1093/brain/awz105
   Delpire E, 2000, NEWS PHYSIOL SCI, V15, P309, DOI 10.1152/physiologyonline.2000.15.6.309
   Diener HC, 1999, CURR OPIN NEUROL, V12, P261, DOI 10.1097/00019052-199906000-00004
   Doyon N, 2013, EXPERT REV NEUROTHER, V13, P469, DOI [10.1586/ERN.13.40, 10.1586/ern.13.40]
   Ferrini F, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17824-y
   Fiumelli H, 2007, CURR OPIN NEUROBIOL, V17, P81, DOI 10.1016/j.conb.2007.01.002
   Friedman BW, 2017, NEUROLOGY, V89, P2075, DOI 10.1212/WNL.0000000000004642
   Gagnon M, 2013, NAT MED, V19, P1524, DOI 10.1038/nm.3356
   GAMSE R, 1981, N-S ARCH PHARMACOL, V316, P38, DOI 10.1007/BF00507224
   Ganguly K, 2001, CELL, V105, P521, DOI 10.1016/S0092-8674(01)00341-5
   Gutierrez-Mecinas M, 2017, PAIN, V158, P440, DOI 10.1097/j.pain.0000000000000778
   Hayek SM, 2015, NEUROMODULATION, V18, P603, DOI 10.1111/ner.12312
   Hochberg MC, 2015, OSTEOARTHR CARTILAGE, V23, pS18, DOI 10.1016/j.joca.2014.10.005
   Hozumi T, 2021, NEUROSCI LETT, V749, DOI 10.1016/j.neulet.2021.135772
   Jaggi AS, 2015, CURR NEUROPHARMACOL, V13, P369, DOI 10.2174/1570159X13666150205130359
   Kahle KT, 2008, NAT CLIN PRACT NEURO, V4, P490, DOI 10.1038/ncpneuro0883
   Kahle KT, 2016, NEUROSCIENTIST, V22, P555, DOI 10.1177/1073858416645087
   Kahle KT, 2016, SCI SIGNAL, V9, DOI 10.1126/scisignal.aad0163
   Kahle KT, 2014, EMBO REP, V15, P766, DOI 10.15252/embr.201438840
   Kahle KT, 2014, JAMA NEUROL, V71, P640, DOI 10.1001/jamaneurol.2014.21
   Kahle KT, 2013, TRENDS NEUROSCI, V36, P726, DOI 10.1016/j.tins.2013.08.006
   Kaplun D, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22147587
   Kelley MR, 2018, EBIOMEDICINE, V32, P62, DOI 10.1016/j.ebiom.2018.05.029
   King GF, 2014, ACS CHEM NEUROSCI, V5, P749, DOI 10.1021/cn500171p
   Kirmse K, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8750
   Kontou G, 2021, J BIOL CHEM, V296, DOI 10.1016/j.jbc.2021.100364
   Lagraize SC, 2010, NEUROSCIENCE, V171, P1341, DOI 10.1016/j.neuroscience.2010.09.040
   Lee HHC, 2011, NAT NEUROSCI, V14, P736, DOI 10.1038/nn.2806
   Lee HHC, 2010, MOL CELL NEUROSCI, V45, P173, DOI 10.1016/j.mcn.2010.06.008
   Li LY, 2016, CELL REP, V15, P1376, DOI 10.1016/j.celrep.2016.04.039
   Li SS, 2018, MOL MED REP, V17, P6961, DOI 10.3892/mmr.2018.8766
   Liabeuf S, 2017, J NEUROTRAUM, V34, P3397, DOI 10.1089/neu.2017.5152
   Liang LL, 2015, EPIGENOMICS-UK, V7, P235, DOI [10.2217/EPI.14.75, 10.2217/epi.14.75]
   Liedtke W, 2013, SMALL, V9, P1066, DOI 10.1002/smll.201201994
   Liu ML, 2016, CELL REP, V14, P115, DOI 10.1016/j.celrep.2015.12.018
   Lopes EC, 2008, CANCER RES, V68, P7258, DOI 10.1158/0008-5472.CAN-08-0344
   Lorenzo LE, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14154-6
   Mantyh PW, 2004, TRENDS NEUROSCI, V27, P582, DOI 10.1016/j.tins.2004.07.007
   Mapplebeck JCS, 2019, CELL REP, V28, P590, DOI 10.1016/j.celrep.2019.06.059
   Medina I, 2014, FRONT CELL NEUROSCI, V8, DOI 10.3389/fncel.2014.00027
   Mekhail N, 2022, JAMA NEUROL, V79, P251, DOI 10.1001/jamaneurol.2021.4998
   Miller RE, 2017, CURR OPIN RHEUMATOL, V29, P110, DOI 10.1097/BOR.0000000000000354
   Morrison D, 2021, MOL PAIN, V17, DOI 10.1177/17448069211007289
   MORTON CR, 1989, BRAIN RES, V488, P89, DOI 10.1016/0006-8993(89)90696-3
   MOSKOWITZ MA, 1993, NEUROLOGY, V43, P16
   Mulcahy JV, 2019, J MED CHEM, V62, P8695, DOI 10.1021/acs.jmedchem.8b01906
   Munro G, 2013, EUR J PHARMACOL, V716, P17, DOI 10.1016/j.ejphar.2013.01.070
   Noorsal E, 2021, MICROMACHINES-BASEL, V12, DOI 10.3390/mi12080968
   Okamoto K, 2001, EXP NEUROL, V169, P386, DOI 10.1006/exnr.2001.7677
   Otsu Y, 2020, J PHYSIOL-LONDON, V598, P1865, DOI 10.1113/JP279221
   Pilitsis JG, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.673998
   Pisella LI, 2019, SCI SIGNAL, V12, DOI 10.1126/scisignal.aay0300
   Prescott SA, 2015, PROG MOL BIOL TRANSL, V131, P359, DOI 10.1016/bs.pmbts.2014.11.008
   Price TJ, 2005, CURR TOP MED CHEM, V5, P547, DOI 10.2174/1568026054367629
   Prokhortchouk A, 2001, GENE DEV, V15, P1613, DOI 10.1101/gad.198501
   Rivat C, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-03496-2
   Rivera C, 1999, NATURE, V397, P251, DOI 10.1038/16697
   Rodriguez E, 2017, NAT NEUROSCI, V20, P1734, DOI 10.1038/s41593-017-0012-1
   SANDKUHLER J, 1990, NEUROSCIENCE, V34, P565, DOI 10.1016/0306-4522(90)90165-Z
   Schulte JT, 2018, NEUROSCI BIOBEHAV R, V90, P260, DOI 10.1016/j.neubiorev.2018.05.001
   Shi TJS, 2014, MOL PAIN, V10, DOI 10.1186/1744-8069-10-12
   Skardelly M, 2011, INT J DEV NEUROSCI, V29, P543, DOI 10.1016/j.ijdevneu.2011.03.010
   SMIRNE S, 1977, MED J AUSTRALIA, V1, P93, DOI 10.5694/j.1326-5377.1977.tb130531.x
   Strange K, 2000, AM J PHYSIOL-CELL PH, V279, pC860, DOI 10.1152/ajpcell.2000.279.3.C860
   Tang X, 2019, SCI TRANSL MED, V11, DOI 10.1126/scitranslmed.aau0164
   Teitz T, 2018, J EXP MED, V215, P1187, DOI 10.1084/jem.20172246
   Uvarov P, 2006, J NEUROSCI, V26, P13463, DOI 10.1523/JNEUROSCI.4731-06.2006
   Wang H, 2002, NEUROSCIENCE, V114, P529, DOI 10.1016/S0306-4522(02)00341-X
   Watanabe M, 2019, SCI SIGNAL, V12, DOI 10.1126/scisignal.aaw9315
   Wei B, 2013, NEUROSCIENCE, V228, P334, DOI 10.1016/j.neuroscience.2012.10.043
   Woo NS, 2002, HIPPOCAMPUS, V12, P258, DOI 10.1002/hipo.10014
   Woodin MA, 2003, NEURON, V39, P807, DOI 10.1016/S0896-6273(03)00507-5
   Wu LA, 2009, NEUROSCI LETT, V457, P36, DOI 10.1016/j.neulet.2009.03.107
   Xiao YC, 2010, MOL PHARMACOL, V78, P1124, DOI 10.1124/mol.110.066332
   Xu B, 2020, BRIT J PHARMACOL, V177, P93, DOI 10.1111/bph.14848
   Yang YM, 2013, CELL STEM CELL, V12, P713, DOI 10.1016/j.stem.2013.04.003
   Yeo M., 2020, NEURONAL CHLORIDE TR
   Yeo M, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-26270-3
   Yeo M, 2013, EPIGENETICS-US, V8, P1128, DOI 10.4161/epi.26406
   Yeo M, 2013, P NATL ACAD SCI USA, V110, P4315, DOI 10.1073/pnas.1300959110
   Yeo M, 2009, J NEUROSCI, V29, P14652, DOI 10.1523/JNEUROSCI.2934-09.2009
   YIN KJ, 1995, ANAT REC, V241, P579, DOI 10.1002/ar.1092410415
   Yuan XC, 2022, MOL PAIN, V18, DOI 10.1177/17448069221087583
   Zeilhofer HU, 2012, PHYSIOL REV, V92, P193, DOI 10.1152/physrev.00043.2010
   Zhang P, 2017, INFLAMMATION, V40, P1102, DOI 10.1007/s10753-017-0552-2
   Zhu L, 2008, EPILEPSY RES, V79, P201, DOI 10.1016/j.eplepsyres.2008.02.005
NR 96
TC 5
Z9 5
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5099
J9 FRONT MOL NEUROSCI
JI Front. Molec. Neurosci.
PD MAY 13
PY 2022
VL 15
AR 865600
DI 10.3389/fnmol.2022.865600
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 1R7XH
UT WOS:000803578200001
PM 35645734
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Münstedt, K
   Thienel, J
   Hrogovic, I
   Hackethal, A
   Kalder, M
   Misselwitz, B
AF Muenstedt, Karsten
   Thienel, Janina
   Hrogovic, Igor
   Hackethal, Andreas
   Kalder, Matthias
   Misselwitz, Bjoern
TI Use of Acupuncture and Other CAM Methods in Obstetrics: An Analysis of
   409,413 Deliveries from Hesse, Germany
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID NULLIPAROUS WOMEN; PAIN RELIEF; LABOR; COMPLEMENTARY; REDUCE
AB Objectives: This study was done to analyze the frequency of use of acupuncture and other complementary and alternative medicine (CAM) methods during labor and to investigate the different characteristics of women being treated with or without acupuncture and CAM methods, as well as try to analyze birth-related outcome measures.
   Study design: Data were analyzed from 409,413 deliveries, registered between 2001 and 2008 by the agency for quality assurance in Hesse (the Hessian Perinatal Registry [HEPE] survey), which made up more than 95% of all deliveries in this German state during the given time period.
   Results: Interest in the use of CAM seems to have decreased within the given time period. On average, acupuncture was used in 3.7% (15,345/409,295) of all deliveries and other CAM methods in 4.8% (19,507/409,295). The most important determinant for the use of one or both methods was the type of hospital. It was also found that German women with higher job qualifications were more likely to receive CAM treatment during delivery. Interestingly, application of CAM methods was associated with a higher use of analgesics during labor. The risk status of the pregnancy or the delivery was of minor importance.
   Conclusions: This analysis shows that the determinants of CAM use are similar to those in the field of oncology. In order to assess the efficacy of acupuncture or other CAM methods in the field of obstetrics, it seems necessary to extend the HEPE survey to cover these areas.
C1 [Muenstedt, Karsten; Hrogovic, Igor; Hackethal, Andreas] Univ Giessen, Dept Obstet & Gynaecol, D-35385 Giessen, Germany.
   [Thienel, Janina] Univ Munich, Munich, Germany.
   [Kalder, Matthias] Univ Marburg, Dept Gynaecol & Gynaecol Endocrinol & Oncol, Marburg, Germany.
   [Misselwitz, Bjoern] Inst Qual Assurance, Eschborn, Germany.
C3 Justus Liebig University Giessen; University of Munich; Philipps
   University Marburg
RP Münstedt, K (corresponding author), Univ Giessen, Dept Obstet & Gynaecol, Klinikstr 32, D-35385 Giessen, Germany.
EM karsten.muenstedt@gyn.med.uni-giessen.de
CR BISHOP FL, 2008, EVID BASED COMP 0313
   Boivin J, 2009, HUM REPROD, V24, P1626, DOI 10.1093/humrep/dep077
   Borup L, 2009, BIRTH-ISS PERINAT C, V36, P5, DOI 10.1111/j.1523-536X.2008.00290.x
   Goerke K, 2000, GYNAKOLOGE, V33, P220, DOI 10.1007/s001290050538
   Hantoushzadeh S, 2007, AUST NZ J OBSTET GYN, V47, P26, DOI 10.1111/j.1479-828X.2006.00674.x
   Koog YH, 2009, J ALTERN COMPLEM MED, V15, P1107, DOI 10.1089/acm.2009.0132
   KUBISTA E, 1973, WIEN KLIN WOCHENSCHR, V85, P628
   KUNZEL W, 1994, EUR J OBSTET GYN R B, V54, P13, DOI 10.1016/0028-2243(94)90075-2
   Lee H, 2004, AM J OBSTET GYNECOL, V191, P1573, DOI 10.1016/j.ajog.2004.05.027
   Mårtensson L, 2011, MIDWIFERY, V27, P93, DOI 10.1016/j.midw.2010.08.011
   MESTLER G E, 1954, Bull Med Libr Assoc, V42, P468
   Münstedt K, 2009, EUR J OBSTET GYN R B, V146, P50, DOI 10.1016/j.ejogrb.2009.05.013
   Münstedt K, 2009, FORSCH KOMPLEMENTMED, V16, P111, DOI 10.1159/000208918
   Nesheim BI, 2003, CLIN J PAIN, V19, P187, DOI 10.1097/00002508-200305000-00006
   Peuker E, 2001, Acupunct Med, V19, P103
   Selmer-Olsen T, 2007, ACTA OBSTET GYN SCAN, V86, P1447, DOI 10.1080/00016340701645287
   Smith CA, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003521.pub2
   SMITH CA, 2001, COCHRANE DB SYST REV, V1
   Smith CA, 2009, BIRTH-ISS PERINAT C, V36, P246, DOI 10.1111/j.1523-536X.2009.00329.x
   So EWS, 2009, HUM REPROD, V24, P341, DOI 10.1093/humrep/den380
   Tournaire M, 2007, EVID-BASED COMPL ALT, V4, P409, DOI 10.1093/ecam/nem012
NR 21
TC 11
Z9 16
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD MAY
PY 2011
VL 17
IS 5
BP 421
EP 426
DI 10.1089/acm.2010.0145
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA 766LP
UT WOS:000290784100007
PM 21554127
DA 2026-01-16
ER

PT J
AU Cheng, L
   Chen, Y
   Li, LJ
AF Cheng, Lan
   Chen, Yu
   Li, Lianjie
TI Crowned dens syndrome combined with cervical disc herniation: A case
   report and literature review
SO MEDICINE
LA English
DT Article
DE case report; cervical disc herniation; Crowned dens syndrome; neck pain;
   odontoid syndrome
AB Rationale:Crowned dens syndrome (CDS) is an unusual and frequently underdiagnosed cause of intense neck pain in older people due to the lack of awareness. The clinical presentation often mimics intracranial infections, which may result in unnecessary invasive procedures and the inappropriate use of antibiotics. The patient had a long-standing history of chronic neck pain, and the acute exacerbation was initially misdiagnosed as cervical disc herniation with suspected intracranial infection before the diagnosis of CDS was established.Patient concerns:We report the first case of an 80-year-old female patient who presented with severe suboccipital neck pain for 10 days, accompanied by restriction of rotational movement of the neck and low-grade fever.Diagnoses and interventions:Differentiating CDS from other potential causes of neck pain, such as degenerative cervical spondylosis, fracture, or metastatic spinal tumors, is challenging given the patient's history and clinical presentation. Initially, the patient was diagnosed with cervical spondylosis. However, treatment with pain-relief patches, acupuncture, and physiotherapy did not alleviate these symptoms. Diagnosis of intracranial infection based on laboratory tests and clinical symptoms cannot be ruled out. However, the antibiotics had no effect. Plain cervical computed tomography revealed typical calcification around the odontoid process. Increased levels of inflammatory markers can contribute to the final diagnosis of CDS. Radiography of the knee joints revealed calcium deposits in the cartilage and ligament tissues, with no apparent alteration, deformity, or destruction of the joints. This finding supported the diagnosis. After combined administration of celecoxib, colchicine, and a short course of corticosteroids, the patient's fever subsided rapidly, and both neck pain and restricted cervical mobility improved significantly. Inflammatory markers, including C-reactive protein and erythrocyte sedimentation rate, decreased rapidly and were within normal limits within 7 days.Outcomes:There was no indication of recurrence, and C-reactive protein and erythrocyte sedimentation rate levels returned to normal at the 2-week follow-up.Lessons:CDS should be considered in cases of acute pain in the neck or occipital regions. Moreover, prompt computed tomography of the cervical vertebrae may guide early diagnosis and avoid unnecessary invasive procedures or administration of antibiotics.
C1 [Cheng, Lan] Ningbo No 2 Hosp, Dept Cardiovasc Med, Ningbo, Zhejiang, Peoples R China.
   [Chen, Yu] Xiangshan Red Cross Taiwan Compatriot Hosp Med & H, Dept Neurosurg, Ningbo, Zhejiang, Peoples R China.
   [Li, Lianjie] Ningbo No 2 Hosp, Dept Neurosurg, 41 Xibei St, Ningbo 315000, Zhejiang, Peoples R China.
RP Li, LJ (corresponding author), Ningbo No 2 Hosp, Dept Neurosurg, 41 Xibei St, Ningbo 315000, Zhejiang, Peoples R China.
EM 1157202624@qq.com; 564600178@qq.com; 798095204@qq.com
CR Awisat A, 2020, CLIN RHEUMATOL, V39, P571, DOI 10.1007/s10067-019-04822-9
   BOUVET JP, 1985, ARTHRITIS RHEUM, V28, P1417, DOI 10.1002/art.1780281215
   Castellanos Gustavo, 2025, Cureus, V17, pe78158, DOI [10.7759/cureus.78158, 10.7759/cureus.78158]
   Ferraccioli G, 2023, RMD OPEN, V9, DOI 10.1136/rmdopen-2023-003017
   Goto S, 2007, J BONE JOINT SURG AM, V89A, P2732, DOI 10.2106/JBJS.F.01322
   Haikal A, 2020, AM J MED, V133, pE32, DOI 10.1016/j.amjmed.2019.06.050
   Hamdan O, 2025, RHEUMATOL INT, V45, DOI 10.1007/s00296-025-05884-6
   Huang P, 2022, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.528663
   Koda R, 2015, INTERNAL MED, V54, P2405, DOI 10.2169/internalmedicine.54.4571
   Morita S, 2025, CLIN CASE REP, V13, DOI 10.1002/ccr3.70168
   Okumura N, 2025, J GEN FAM MED, V26, P267, DOI 10.1002/jgf2.780
   Palmowski A, 2025, CAN J EMERG MED, V27, P233, DOI 10.1007/s43678-024-00850-w
   Sakhamuru P., 2025, Cureus, V17, pe84853
   Tang J, 2020, EXP THER MED, V20, P3853, DOI 10.3892/etm.2020.9128
   Wang SM, 2023, QUANT IMAG MED SURG, V13, P4984, DOI 10.21037/qims-22-1387
   Yang X, 2022, BONE JOINT J, V104B, P1242, DOI 10.1302/0301-620X.104B11.BJJ-2022-0657.R2
NR 16
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 31
PY 2025
VL 104
IS 44
AR e45039
DI 10.1097/MD.0000000000045039
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9ZK4O
UT WOS:001618674700036
PM 41261598
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Alsabri, M
   Yeluru, A
   Basak, RB
AF Alsabri, Mohammed
   Yeluru, Ajitha
   Basak, Ratna B.
TI Ancillary Services in Pediatric Departments of USA
SO INDIAN PEDIATRICS
LA English
DT Article
DE Art; Clowning; Health; Hospital; Music; Pets
ID PROCEDURE-RELATED PAIN; MUSIC-THERAPY; ALTERNATIVE MEDICINE;
   ART-THERAPY; CHILDREN; HYPNOSIS; CANCER; COMPLEMENTARY; CHEMOTHERAPY;
   ACUPUNCTURE
AB It is well known that prolonged hospitalizations and medical procedures have adverse psychological impact on children. Ancillary services in the pediatric departments help in mitigating stress, improve patient satisfaction, reduce procedural time, and improve the quality of life. This can be translated to measurable outcomes such as less doctor's visits, fewer symptoms, early discharge and fewer medications. Other benefits include conserving staff time and energy, thereby increasing productivity, staff retention and decreasing burnout. As more free-standing children's hospitals emerge, the ancillary services will gain more recognition and popularity to give the best patient care experience.
C1 [Alsabri, Mohammed; Yeluru, Ajitha; Basak, Ratna B.] Brookdale Univ Hosp Med Ctr, Dept Pediat, One Brookdale Plaza, New York, NY 11212 USA.
RP Basak, RB (corresponding author), Brookdale Univ Hosp Med Ctr, Dept Pediat, One Brookdale Plaza, New York, NY 11212 USA.
EM ratnabimalbasak@gmail.com
CR Abasi Z, 2011, J N KHORASAN U MED S, V3, P51, DOI [10.29252/jnkums.3.3.51, DOI 10.29252/JNKUMS.3.3.51]
   Ali Babar, 2015, Asian Pacific Journal of Tropical Biomedicine, V5, P601, DOI [10.1016/j.apjtb.2015.05.007, 10.1016/j.apjtb.2015.05.007]
   American Academy of Pediatrics Committee on Hospital Care, 1986, HDB HOSP CAR CHILDR
   [Anonymous], 2014, HIST AN ASS THER
   [Anonymous], 2014, GLOBAL J HLTH SCI
   [Anonymous], 2004, COCHRANE DB SYST REV
   [Anonymous], 1946, PURPOSE FAMILY GUIDE
   Barrera ME, 2002, PSYCHO-ONCOL, V11, P379, DOI 10.1002/pon.589
   Basak RB, 2019, J PAIN SYMPTOM MANAG, V58, P735, DOI 10.1016/j.jpainsymman.2019.05.022
   Beebe A, 2010, J ALLERGY CLIN IMMUN, V126, P263, DOI 10.1016/j.jaci.2010.03.019
   Bieleninik L, 2016, PEDIATRICS, V138, DOI 10.1542/peds.2016-0971
   Bremner J Douglas, 2006, Dialogues Clin Neurosci, V8, P445
   Bustad L., 1980, Animals, Aging, and the Aged, DOI [DOI 10.5749/J.CTTTT4CW, 10.5749/j.ctttt4cw]
   Dain AS, 2015, J PAIN SYMPTOM MANAG, V49, P1035, DOI 10.1016/j.jpainsymman.2014.11.295
   Ernst E, 2000, B WORLD HEALTH ORGAN, V78, P252
   Gagnon Johanne, 2004, Can Oncol Nurs J, V14, P217
   Ghetti CM, 2013, J MUSIC THER, V50, P93, DOI 10.1093/jmt/50.2.93
   Gomberg J, 2020, CLIN MED INSIGHTS-PE, V14, DOI 10.1177/1179556520909376
   Grebosz-Haring K, 2018, HELIYON, V4, DOI 10.1016/j.heliyon.2018.e01014
   Groenewald CB, 2017, ACAD PEDIATR, V17, P785, DOI 10.1016/j.acap.2017.02.008
   Jindal V, 2008, J PEDIAT HEMATOL ONC, V30, P431, DOI 10.1097/MPH.0b013e318165b2cc
   Kaminski M, 2002, CHILD HEALTH CARE, V31, P321, DOI 10.1207/S15326888CHC3104_5
   Kemper KJ, 2000, PEDIATRICS, V105, P941
   Knott D, 2020, J MUSIC THER, V57, P34, DOI 10.1093/jmt/thz019
   Könsgen N, 2019, SYST REV-LONDON, V8, DOI 10.1186/s13643-019-1095-4
   Kong LJ, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/613279
   Längler A, 2013, COMPLEMENT THER MED, V21, pS26, DOI 10.1016/j.ctim.2012.01.005
   Landier W, 2010, J PEDIATR NURS, V25, P566, DOI 10.1016/j.pedn.2010.01.009
   Liossi C, 2003, INT J CLIN EXP HYP, V51, P4, DOI 10.1076/iceh.51.1.4.14064
   Lookabaugh S, 2018, J CHILD FAM STUD, V27, P1721, DOI 10.1007/s10826-018-1031-6
   Malchiodi C.A., 1999, Medical art therapy with children
   Martin L, 2018, BEHAV SCI-BASEL, V8, DOI 10.3390/bs8020028
   Metzl E, 2016, Canadian Art Therapy Association Journal, V29, P3, DOI [10.1080/08322473.2016.1170496, 10.1080/08322473.2016.1170496, DOI 10.1080/08322473.2016.1170496, https://doi.org/10.1080/08322473.2016.1170496, 10.1080/08322473.2016, DOI 10.1080/08322473.2016]
   Michelson KN, 2018, CLIN PEDIAT EMERG ME, V83, P212
   MORGAN AH, 1979, AM J CLIN HYPN, V21, P148
   Ndao DH, 2012, PSYCHO-ONCOLOGY, V21, P247, DOI 10.1002/pon.1898
   Post-White J, 2009, J PEDIATR ONCOL NURS, V26, P16, DOI 10.1177/1043454208323295
   Reindl TK, 2006, SUPPORT CARE CANCER, V14, P172, DOI 10.1007/s00520-005-0846-z
   Richardson J, 2007, EUR J CANCER CARE, V16, P402, DOI 10.1111/j.1365-2354.2006.00736.x
   Richardson J, 2006, J PAIN SYMPTOM MANAG, V31, P70, DOI 10.1016/j.jpainsymman.2005.06.010
   Riley S, 2001, WESTERN J MED, V175, P54, DOI 10.1136/ewjm.175.1.54
   Shaw SR, 2008, PSYCHOL SCHOOLS, V45, P74, DOI 10.1002/pits.20280
   Shefer S, 2019, EUR J PEDIATR, V178, P1283, DOI 10.1007/s00431-019-03415-7
   Silva NB, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194731
   Steinke SM, 2016, Physical Disabilities Education and Related Services, V35, P28, DOI [10.14434/pders.v35i1.20896, 10.14434/pders.v35i1.20896, DOI 10.14434/PDERS.V35I1.20896]
   Still G F., 1931, The history of pediatrics: the progress of the study of diseases of children up to the end of the XVIIIth century
   Stuckey HL, 2010, AM J PUBLIC HEALTH, V100, P254, DOI 10.2105/AJPH.2008.156497
   Vanhaudenhuyse A, 2008, Rev Med Liege, V63, P424
   Xinghua BB, 2001, ACUPUNCTURE VISIBLE
   Yinger OS, 2016, J MUSIC THER, V53, P336, DOI 10.1093/jmt/thw010
NR 50
TC 0
Z9 0
U1 0
U2 14
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0019-6061
EI 0974-7559
J9 INDIAN PEDIATR
JI Indian Pediatrics
PD NOV
PY 2020
VL 57
IS 11
BP 999
EP 1003
DI 10.1007/s13312-020-2022-4
PG 5
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA OT8WE
UT WOS:000591119000002
PM 33231173
DA 2026-01-16
ER

PT J
AU Maschio, M
   Mengarelli, A
   Zarabla, A
   Giannarelli, D
   Maialetti, A
   Gumenyuk, S
   Renzi, D
   Palombi, F
   Pisani, F
   Romano, A
   Spadea, A
   Galiè, E
   Marchesi, F
AF Maschio, Marta
   Mengarelli, Andrea
   Zarabla, Alessia
   Giannarelli, Diana
   Maialetti, Andrea
   Gumenyuk, Svetlana
   Renzi, Daniela
   Palombi, Francesca
   Pisani, Francesco
   Romano, Atelda
   Spadea, Antonio
   Galie, Edvina
   Marchesi, Francesco
TI Role of Pregabalin in Treatment of Polyneuropathy in Multiple Myeloma
   Patients: A Retrospective Study
SO CLINICAL NEUROPHARMACOLOGY
LA English
DT Review
DE polyneuropathy; multiple myeloma; pregabalin; neurophysiological data;
   chemotherapy; bortezomib
ID INDUCED PERIPHERAL NEUROPATHY; BORTEZOMIB; MANAGEMENT; PREVENTION;
   NEUROTOXICITY; ACUPUNCTURE; GUIDELINES; CONSENSUS; SYSTEM
AB Objectives Polyneuropathy (PN) is a frequent and significant clinical manifestation of multiple myeloma that may be observed at onset of disease or induced during treatment as a therapy-related complication. Polyneuropathy may be a relevant issue in myeloma patients owing to its significant impact on the quality of life, considering that it may lead to dose reduction or treatment discontinuation. The present retrospective study intended to evaluate efficacy of pregabalin (PGB) in treatment of PN in multiple myeloma patients. Materials and Methods Medical charts of 108 consecutive PN myeloma patients were reviewed. Data regarding the tumor history and therapy as well as the clinical and neurophysiological examinations 6 months before and after initiation of PGB therapy were collected. Results Thirty-eight medical charts had all the requested information. All patients (n = 38) underwent bortezomib-based treatment; 19 were previously treated and 19 were treatment naive. At first neurologic visit, all patients had PN symptoms (grade 2 of National Cancer Institute-Common Toxicity Criteria) without relevant pain. Neurophysiological evaluation showed a significant decrease in sensory nerve action potential amplitude (P = 0.006), conduction velocity (P = 0.006), and distal latency (P = 0.03) of sensory nerves between the first and the last neurological examination, in all patient population. Similar results were observed in treatment-naive patients, when the study cohort was stratified according to previous treatment. On the contrary, no significant differences were found between the first and the last neurophysiological follow-up evaluation in previously treated patients. Six months after PGB treatment, all patients reported disappearance of neurological symptoms (grade 0 National Cancer Institute-Common Toxicity Criteria). Conclusions In this retrospective study, improvement in neurological symptoms during PGB therapy was observed in the total population, despite the presence of a distal, sensory axonal neuropathy, as evidenced by neurophysiological examination.
C1 [Maschio, Marta; Zarabla, Alessia; Maialetti, Andrea] IRCCS Regina Elena Natl Canc Inst, UOSD Neurol, Ctr Tumor Related Epilepsy, Via Elio Chianesi 55, I-00144 Rome, Italy.
   [Mengarelli, Andrea; Gumenyuk, Svetlana; Renzi, Daniela; Palombi, Francesca; Pisani, Francesco; Romano, Atelda; Spadea, Antonio; Marchesi, Francesco] IRCCS Regina Elena Natl Canc Inst, Hematol & Stem Cell Transplantat Unit, Rome, Italy.
   [Giannarelli, Diana] IRCCS Regina Elena Natl Canc Inst, Biostat Unit, Rome, Italy.
   [Galie, Edvina] IRCCS Regina Elena Natl Canc Inst, UOSD Neurol, Rome, Italy.
RP Maschio, M (corresponding author), IRCCS Regina Elena Natl Canc Inst, UOSD Neurol, Ctr Tumor Related Epilepsy, Via Elio Chianesi 55, I-00144 Rome, Italy.
EM marta.maschio@ifo.gov.it
RI ; Marchesi, Francesco/ABH-8310-2020; Maschio, Marta/H-8872-2017; Pisani,
   Francesco/ABH-8545-2020; Mengarelli, Anea/ABH-6559-2020; Giannarelli,
   Diana/T-5507-2017
OI SPADEA, ANTONIO/0000-0002-3651-2951; Marchesi,
   Francesco/0000-0001-6353-2272; Pisani, Francesco/0000-0002-6853-5605;
   Mengarelli, Anea/0000-0002-2606-2467; Giannarelli,
   Diana/0000-0002-6085-1195
CR [Anonymous], 2009, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD007076.pub2
   Antoine JC, 2007, LANCET NEUROL, V6, P75, DOI 10.1016/S1474-4422(06)70679-2
   Bao T, 2014, INTEGR CANCER THER, V13, P396, DOI 10.1177/1534735414534729
   Beijers AJM, 2016, SUPPORT CARE CANCER, V24, P2411, DOI 10.1007/s00520-015-3032-y
   Beijers AJM, 2012, NETH J MED, V70, P18
   Bilinska M, 2013, WSPOLCZESNA ONKOL, V17, P421, DOI 10.5114/wo.2013.37214
   Callander N, 2014, CANCER CHEMOTH PHARM, V74, P875, DOI 10.1007/s00280-014-2550-5
   Cavaletti G, 2013, ANN ONCOL, V24, P454, DOI 10.1093/annonc/mds329
   Delforge M, 2010, LANCET ONCOL, V11, P1086, DOI 10.1016/S1470-2045(10)70068-1
   Garcia MK, 2014, J HEMATOL ONCOL, V7, DOI 10.1186/1756-8722-7-41
   Han XY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-016-3037-z
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Javed Saad, 2015, Rev Diabet Stud, V12, P63, DOI [10.1900/rds.2015.12.63, 10.1900/RDS.2015.12.63]
   Koeppen S, 2014, ONCOL RES TREAT, V37, P506, DOI 10.1159/000365534
   Lanzani F, 2008, J PERIPHER NERV SYST, V13, P267, DOI 10.1111/j.1529-8027.2008.00192.x
   Leone C, 2016, NEUROL SCI, V37, P1141, DOI 10.1007/s10072-016-2542-9
   Mallick-Searle T, 2016, J MULTIDISCIP HEALTH, V9, DOI 10.2147/JMDH.S106340
   Maschio M, 2018, INTEGR CANCER THER, V17, P1115, DOI 10.1177/1534735418803758
   Mohty B, 2010, HAEMATOL-HEMATOL J, V95, P311, DOI 10.3324/haematol.2009.012674
   Morawska M, 2015, HEMATOL ONCOL, V33, P113, DOI 10.1002/hon.2149
   Moulin DE, 2014, PAIN RES MANAG, V19, P328
   Nagahara Hisashi, 2013, Gan To Kagaku Ryoho, V40, P1181
   Nasu S, 2014, CLIN NEUROPHYSIOL, V125, P381, DOI 10.1016/j.clinph.2013.07.014
   Pachman DR, 2011, CLIN PHARMACOL THER, V90, P377, DOI 10.1038/clpt.2011.115
   Park SB, 2013, CA-CANCER J CLIN, V63, P419, DOI 10.3322/caac.21204
   Postma TJ, 2000, ANN ONCOL, V11, P509, DOI 10.1023/A:1008345613594
   Richardson PG, 2012, LEUKEMIA, V26, P595, DOI 10.1038/leu.2011.346
   Saif MW, 2010, ANTICANCER RES, V30, P2927
   SCOTT J, 1976, PAIN, V2, P175, DOI 10.1016/0304-3959(76)90113-5
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Shinde SS, 2016, SUPPORT CARE CANCER, V24, P547, DOI 10.1007/s00520-015-2807-5
   Snowden JA, 2011, BRIT J HAEMATOL, V154, P76, DOI 10.1111/j.1365-2141.2011.08574.x
   Sonneveld P, 2010, HEMATOL-AM SOC HEMAT, P423, DOI 10.1182/asheducation-2010.1.423
   Terpos E, 2015, HAEMATOLOGICA, V100, P1254, DOI 10.3324/haematol.2014.117176
   Trotti A, 2003, SEMIN RADIAT ONCOL, V13, P176, DOI 10.1016/S1053-4296(03)00031-6
   Windebank AJ, 2008, J PERIPHER NERV SYST, V13, P27, DOI 10.1111/j.1529-8027.2008.00156.x
   Zhang Li-Li, 2017, Zhongguo Shi Yan Xue Ye Xue Za Zhi, V25, P480, DOI 10.7534/j.issn.1009-2137.2017.02.031
NR 37
TC 2
Z9 3
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0362-5664
EI 1537-162X
J9 CLIN NEUROPHARMACOL
JI Clin. Neuropharmacol.
PD SEP-OCT
PY 2019
VL 42
IS 5
BP 167
EP 171
DI 10.1097/WNF.0000000000000360
PG 5
WC Clinical Neurology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA KA3VD
UT WOS:000505725500004
PM 31361668
DA 2026-01-16
ER

PT J
AU Xie, DW
   Shi, XY
   Zhang, YX
AF Xie, Duowen
   Shi, Xiaoyuan
   Zhang, Yinxia
TI Effect of Combined Acupuncture Anesthesia on Surgical Dosage and Serum
   IL-4, IL-10 of Pneumonectomy Patients
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Combined acupuncture anesthesia; Pneumonectomy; Propofol; Fentanyl;
   Interleukin-4; Interleukin-10
ID CANCER; STIMULATION; FREQUENCY; IMMUNE; CELL
AB Objective: To analyse the effects of combined acupuncture anesthesia on surgical dosage and serum interleukin-4 (IL-4), interleukin-10 (IL-10) of pneumonectomy patients.
   Study Design: A randomised controlled trial (RCT).
   Place and Duration of Study: Lanzhou University Second Hospital, Lanzhou, China, from January 2016 to November 2017.
   Methodology: A total of 110 patients undergoing pneumonectomy were randomly divided into group A and group B, with 55 cases in each group. Group A was treated with combined 2Hz acupuncture anesthesia, while group B was treated with combined 2Hz/100Hz acupuncture anesthesia. The additional propofol, fentanyl dosage, and changes in heart rate and systolic blood pressure 5 min before and during extubation were compared between the two groups. The serum IL-4 and IL-10 levels were measured 10 minutes after skin incision and 24 hours after surgery using ELISA. Pain was rated by visual analogue scale (VAS) at 24 hours after surgery.
   Results: There was no statistically significant difference between group A and group B in the intraoperative additional propofol and fentanyl dosags (p=0.541 and 0.719, respectively). There is no statistical difference in heart rate and systolic blood pressure between group A and group B at 5 minutes before and during extubation (p=0.151, 0.660 and 0.734, 0.528, respectively). There is no statistical difference between group A and group B in serum IL-4 and IL-10 levels 10 minutes after surgical incision (p=0.916 and 0.841, respectively). However, serum IL-4 and IL-2 levels in group A are statistically lower than that of group B at 24 hours after surgery (all p<0.001). The VAS score at 24 hours after surgery in group A was 2.44 +/- 0.71 points, which was significantly lower than that of group B (3.82 +/- 0.77 points, p<0.001).
   Conclusion: Combined 2 Hz, 2 Hz/100 Hz acupuncture anesthesia need few anesthetic dosages of propofol and fentanyl to stabilise the patient's blood pressure and heart rate when intubated under general anesthesia; but combined 2 Hz acupuncture anesthesia can reduce IL-4 and IL-10 levels during surgery stress to a greater extent than the latter, and can effectively lower patients' serum IL-4, IL-10 expression after surgery.
C1 [Xie, Duowen] Lanzhou Univ, Hosp 2, Dept Intens Care Unit, Lanzhou 730000, Gansu, Peoples R China.
   [Shi, Xiaoyuan] Lanzhou Univ, Hosp 2, Med Record, Lanzhou 730000, Gansu, Peoples R China.
   [Zhang, Yinxia] Northwest Minzu Univ Hosp, Dept Hlth, Lanzhou 730000, Gansu, Peoples R China.
C3 Lanzhou University; Lanzhou University
RP Zhang, YX (corresponding author), Northwest Minzu Univ Hosp, Dept Hlth, Lanzhou 730000, Gansu, Peoples R China.
EM pu088u@163.com
CR Abeles G, 1999, DERMATOL SURG, V25, P559, DOI 10.1046/j.1524-4725.1999.98225.x
   Agelink MW, 2003, FORTSCHR NEUROL PSYC, V71, P141, DOI 10.1055/s-2003-37756
   Ding C, 2008, J CLIN ENDOCR METAB, V93, P1952, DOI 10.1210/jc.2007-2325
   Fan Wen-Chao, 2012, Zhongguo Zhen Jiu, V32, P715
   Fu Guo-qiang, 2011, Zhen Ci Yan Jiu, V36, P361
   Glocker EO, 2009, NEW ENGL J MED, V361, P2033, DOI 10.1056/NEJMoa0907206
   Gomes M, 2012, GENE, V504, P111, DOI 10.1016/j.gene.2012.05.008
   Hamza MA, 1999, ANESTHESIOLOGY, V91, P1232, DOI 10.1097/00000542-199911000-00012
   Kim SB, 2014, J ACUPUNCT MERIDIAN, V7, P122
   Liu LY, 2015, CHINESE J PHYSIOL, V58, P165, DOI 10.4077/CJP.2015.BAD290
   Min Yihua, 2015, Zhongguo Zhen Jiu, V35, P367
   Peng Li-chao, 2008, Zhongguo Zhen Jiu, V28, P910
   Ramanathan M, 2008, AM J RHINOL, V22, P115, DOI 10.2500/ajr.2008.22.3136
   Romita VV, 1997, BRAIN RES BULL, V42, P289, DOI 10.1016/S0361-9230(96)00264-X
   Sharma A, 2007, AM J REPROD IMMUNOL, V58, P21, DOI 10.1111/j.1600-0897.2007.00486.x
   Sharma S, 1999, J IMMUNOL, V163, P5020
   Széchenyi I, 2015, MED ACUPUNCT, V27, P23, DOI 10.1089/acu.2014.1072
   Vijayalakshmi I, 2014, Indian J Physiol Pharmacol, V58, P69
   Wang NK, 2018, ONCOL LETT, V15, P189, DOI 10.3892/ol.2017.7262
   Wang Y, 1993, Zhen Ci Yan Jiu, V18, P44
   Yang Q G, 2001, Zhongguo Zhong Xi Yi Jie He Za Zhi, V21, P729
NR 21
TC 3
Z9 4
U1 1
U2 21
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD NOV
PY 2018
VL 28
IS 11
BP 817
EP 820
DI 10.29271/jcpsp.2018.11.817
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GZ6NX
UT WOS:000449556100002
PM 30369370
OA Bronze
DA 2026-01-16
ER

PT J
AU Jang, S
   Kim, KH
AF Jang, Soobin
   Kim, Kyeong Han
TI Clinical Effectiveness and Adverse Events of Bee Venom Therapy: A
   Systematic Review of Randomized Controlled Trials
SO TOXINS
LA English
DT Review
DE bee venom; bee venom therapy; bee venom acupuncture; bee sting;
   efficacy; safety
ID ADHESIVE CAPSULITIS; ACUPUNCTURE; PAIN; ARTHRITIS; PHYSIOTHERAPY;
   MECHANISM
AB Bee venom has been used to treat many diseases because of its anti-inflammatory and analgesic effects. However, the secretions of bee venom can also cause life-threatening adverse reactions. The objective of this paper was to review the clinical effectiveness of bee venom and adverse events induced by bee venom, regardless of the disease. Four electronic databases were searched in April 2020. The reference lists of the retrieved articles and previous review articles were also hand-searched. Randomized controlled trials (RCTs) using any type of bee venom other than live bee stings for the clinical treatment of any disease other than cancer were included. The studies were selected, the data were extracted, and the quality of the studies was assessed by two authors. Risk of bias was assessed using the Cochrane risk of bias standards. Twelve RCTs were included in this review-three on Parkinson's disease, four on arthralgia, four on musculoskeletal disorders, and one on polycystic ovary syndrome. The types of bee venom used were acupuncture injections, ultrasound gel, and an ointment. Six studies reported adverse events, and skin reactions such as pruritus and swelling were the most common. The large-scale clinical trials of bee venom therapy are needed to verify the statistical difference, and the reporting system for adverse events is also required to increase the safety of bee venom therapy.
C1 [Jang, Soobin] Korea Inst Oriental Med, Clin Med Div, Daejeon 34054, South Korea.
   [Kim, Kyeong Han] Woosuk Univ, Coll Korean Med, Dept Prevent Med, Jeonju 54986, Jeollabuk Do, South Korea.
C3 Korea Institute of Oriental Medicine (KIOM); Woosuk University
RP Kim, KH (corresponding author), Woosuk Univ, Coll Korean Med, Dept Prevent Med, Jeonju 54986, Jeollabuk Do, South Korea.
EM suebin@nate.com; solip922@hanmail.net
RI Jang, Soobin/ODN-1434-2025
OI Jang, Soobin/0000-0003-0943-9290; KIM, KYEONG HAN/0000-0003-4868-9145
FU National Research Foundation of Korea [NRF-2019R1C1C1007573]
FX This work was funded by National Research Foundation of Korea
   (NRF-2019R1C1C1007573).
CR Ahn C.B., 2001, J DONG EUI ORIENT ME, V5, P23
   Aufschnaiter A, 2020, TOXINS, V12, DOI 10.3390/toxins12020066
   Baek YH, 2006, BRAIN RES, V1073, P305, DOI 10.1016/j.brainres.2005.12.086
   Cagnie B, 2003, PHYS THER, V83, P707, DOI 10.1093/ptj/83.8.707
   Castro HJ, 2005, ALLERGY ASTHMA PROC, V26, P470
   Chen HS, 2010, BRAIN RES, V1355, P61, DOI 10.1016/j.brainres.2010.08.002
   Chen J, 2010, PROG NEUROBIOL, V92, P151, DOI 10.1016/j.pneurobio.2010.06.006
   Chen SH, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar2926
   Cho SY, 2018, J ALTERN COMPLEM MED, V24, P25, DOI 10.1089/acm.2016.0250
   Cho SY, 2012, PARKINSONISM RELAT D, V18, P948, DOI 10.1016/j.parkreldis.2012.04.030
   Choi MS, 2013, CYTOKINE, V61, P256, DOI 10.1016/j.cyto.2012.10.005
   Conrad VJ, 2019, J ALTERN COMPLEM MED, V25, P845, DOI 10.1089/acm.2019.0121
   Cumpston M, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000142
   Hartmann A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158235
   Heo D.S., 2005, J ORIENT REHAB MED, V15, P171
   Kim SK, 2014, J PHYS THER SCI, V26, P1419, DOI 10.1589/jpts.26.1419
   Kim TaeHwa Kim TaeHwa, 2006, Journal of Veterinary Clinics, V23, P190
   권기록, 2001, Journal of Pharmacopuncture, V4, P127, DOI 10.3831/KPI.2001.4.3.127
   Koh PS, 2013, J SHOULDER ELB SURG, V22, P1053, DOI 10.1016/j.jse.2012.10.045
   Korean Pharmacopuncutre Institute, 2019, PHARM
   Kwon YB, 2002, LIFE SCI, V71, P191, DOI 10.1016/S0024-3205(02)01617-X
   박원, 2010, Journal of Acupuncture Research, V27, P105
   Lee G, 2016, TOXINS, V8, DOI 10.3390/toxins8020048
   Lee JY, 2005, IN VIVO, V19, P801
   Lee MS, 2008, J PAIN, V9, P289, DOI 10.1016/j.jpain.2007.11.012
   Lim J.A., 2005, J PHARMACOPUNCT, V20, P73, DOI [10.3831/KPI.2005.8.2.029, DOI 10.3831/KPI.2005.8.2.029]
   Mohamed E.A., 2016, INT J PHARMTECH RES, V9, P66
   Nitecka-Buchta A, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/296053
   Park JE, 2019, EUR J INTEGR MED, V27, P121, DOI 10.1016/j.eujim.2019.03.001
   Park JH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126971
   Park JS, 2013, INT J DERMATOL, V52, P1519, DOI 10.1111/ijd.12161
   Park YC, 2014, J ALTERN COMPLEM MED, V20, P919, DOI 10.1089/acm.2014.0220
   Seo BK, 2017, TOXINS, V9, DOI 10.3390/toxins9110361
   Shamseer L, 2015, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g7647
   Shin BC, 2012, EUR J INTEGR MED, V4, pE271, DOI 10.1016/j.eujim.2012.02.005
   Son DJ, 2007, PHARMACOL THERAPEUT, V115, P246, DOI 10.1016/j.pharmthera.2007.04.004
   심우행, 2011, [Korean Journal of Dermatology, 대한피부과학회지], V49, P374
   Surh YJ, 2001, MUTAT RES-FUND MOL M, V480, P243, DOI 10.1016/S0027-5107(01)00183-X
   World Health Organization Regional Office for the Western Pacific (WPRO), 2007, WHO INT STAND TERM T
   Yang MS, 2008, ANN ALLERG ASTHMA IM, V100, P31, DOI 10.1016/S1081-1206(10)60401-2
   Yasin M. M., 2018, Journal of Applied Pharmaceutical Science, V8, P159, DOI 10.7324/japs.2018.8124
   유덕선, 2011, [Journal of Korean Medicine Rehabilitation, 한방재활의학과학회지], V21, P101
   Zhang S, 2018, TOXICON, V148, P64, DOI 10.1016/j.toxicon.2018.04.012
NR 43
TC 31
Z9 34
U1 1
U2 34
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6651
J9 TOXINS
JI Toxins
PD SEP
PY 2020
VL 12
IS 9
AR 558
DI 10.3390/toxins12090558
PG 16
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA OF9BX
UT WOS:000581494500001
PM 32872552
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zou, X
   Chen, ZY
   Yang, YH
   Qiao, Y
   He, SJ
   Li, Q
   Chen, WL
   Zhang, XY
   Li, SY
   Sha, SY
   Hu, MH
   Zhang, XY
   Yang, MJ
   Wang, RP
   Wu, HG
   Shi, Y
   Xue, XH
   Ji, YJ
AF Zou, Xuan
   Chen, Zi-Yi
   Yang, Yu-Han
   Qiao, Yu
   He, Shu-Jin
   Li, Qiong
   Chen, Wei-Li
   Zhang, Xin-Yue
   Li, Si-Yu
   Sha, Shan-Yan
   Hu, Min-Hao
   Zhang, Xi-Yin
   Yang, Ming-Ju
   Wang, Rui-Ping
   Wu, Huan-Gan
   Shi, Yin
   Xue, Xiao-Hong
   Ji, Ya-Jie
TI Acupoint Thread Embedding Combined With Wenshen Bugu Decoction for the
   Treatment of Aromatase Inhibitor-Associated Musculoskeletal Symptom
   Among Postmenopausal Breast Cancer Patients: Study Protocol of a
   Randomized Controlled Trial
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE aromatase inhibitor-associated musculoskeletal symptom (AIMSS); acupoint
   thread embedding (ATE); Wenshen Bugu Decoction; breast cancer; endocrine
   therapy
ID QUALITY-OF-LIFE; ACUPUNCTURE; THERAPY; WOMEN; VALIDITY; OSTEOPOROSIS;
   MANAGEMENT; TAMOXIFEN; ADHERENCE
AB Background:Aromatase inhibitors (AIs) are recommended as the preferred therapy for postmenopausal women with hormone receptor-positive (HR+) breast cancer. As a result, aromatase inhibitor-associated musculoskeletal symptom (AIMSS) have become a major problem leading to therapy discontinuation and decreased quality of life in patients receiving adjuvant AIs treatment. Multiple therapies have been attempted, but have yielded limited clinical results. This study will be performed to determine whether acupoint thread embedding (ATE) combined with Wenshen Bugu Decoction can effectively treat AIMSS, so as to improve the AIs medication compliance of postmenopausal breast cancer patients. Methods:This study will utilize a randomized, 2 parallel groups controlled trial design. A total of 128 eligible postmenopausal breast cancer women with AIMSS will be randomized to receive a 12-week treatment with Wenshen Bugu Decoction alone (control group) or in combination with ATE (treatment group) in a 1:1 ratio. The primary outcome will be the 12 week Brief Pain Inventory Worst Pain (BPI-WP) score. The secondary outcome measures will include response rate, Brief Pain Inventory-Short Form (BFI-SF), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Functional Assessment of Cancer Therapy-Endocrine Symptom (FACT-ES), Functional Assessment of Cancer Therapy-Breast (FACT-B), bone marrow density (BMD), blood markers of bone metabolite, Morisky medication adherence scale-8 (MMAS-8), credibility and expectancy, and survival outcomes. Discussion:This trial may provide clinical evidence that ATE combined with Wenshen Bugu Decoction can be beneficial for treating AIMSS among postmenopausal breast cancer survivors. Our findings will be helpful to enhance the quality of life and reduce the occurrence of AIs withdrawal.
C1 [Zou, Xuan; Chen, Zi-Yi; Yang, Yu-Han; Qiao, Yu; He, Shu-Jin; Li, Qiong; Chen, Wei-Li; Zhang, Xin-Yue; Li, Si-Yu; Sha, Shan-Yan; Hu, Min-Hao; Zhang, Xi-Yin; Yang, Ming-Ju; Xue, Xiao-Hong; Ji, Ya-Jie] Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China.
   [Zou, Xuan; Chen, Zi-Yi; Qiao, Yu; He, Shu-Jin; Zhang, Xi-Yin; Wu, Huan-Gan; Shi, Yin; Ji, Ya-Jie] Shanghai Res Inst Acupuncture & Meridian, Shanghai, Peoples R China.
   [Wang, Rui-Ping] Tongji Univ, Shanghai, Peoples R China.
   [Xue, Xiao-Hong; Ji, Ya-Jie] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrat Chinese & Western Med, 110,Ganhe Rd, Shanghai 200437, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Tongji University;
   Shanghai University of Traditional Chinese Medicine
RP Xue, XH; Ji, YJ (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrat Chinese & Western Med, 110,Ganhe Rd, Shanghai 200437, Peoples R China.
EM 195641459@qq.com; 2373602874@qq.com
CR [Anonymous], 1994, World Health Organ Tech Rep Ser, V843, P1
   BELLAMY N, 1988, J RHEUMATOL, V15, P1833
   Bian ZX, 2011, ANN INTERN MED, V154, P290, DOI 10.7326/0003-4819-154-4-201102150-00016
   Brady MJ, 1997, J CLIN ONCOL, V15, P974, DOI 10.1200/JCO.1997.15.3.974
   Butani D, 2021, BREAST CANCER-TARGET, V13, P625, DOI 10.2147/BCTT.S331831
   Chai C., 2016, EFFECTS RUAI SHUHOU
   Chen T, 2020, AM J CHINESE MED, V48, P793, DOI 10.1142/S0192415X20500408
   Chim K, 2013, BMC CANCER, V13, DOI 10.1186/1471-2407-13-401
   Coombes RC, 2004, NEW ENGL J MED, V350, P1081, DOI 10.1056/NEJMoa040331
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Devilly GJ, 2000, J BEHAV THER EXP PSY, V31, P73, DOI 10.1016/S0005-7916(00)00012-4
   Farrar JT, 2001, PAIN, V94, P149, DOI 10.1016/S0304-3959(01)00349-9
   G-Tsadik D, 2020, INT J HYPERTENS, V2020, DOI 10.1155/2020/9540810
   Ge L, 2022, CHIN MED-UK, V17, DOI 10.1186/s13020-021-00558-4
   Goldhirsch A, 2007, ANN ONCOL, V18, P1133, DOI 10.1093/annonc/mdm271
   Gradishar W J., 2021, Journal of the National Comprehensive Cancer Network, DOI DOI 10.6004/JNCCN.2021.0023
   Gradishar WJ, 2020, J NATL COMPR CANC NE, V18, P452, DOI 10.6004/jnccn.2020.0016
   He SJ., 2023, ACAD J SHANGHAI U TR, V37, P76
   Hershman DL, 2018, JAMA-J AM MED ASSOC, V320, P167, DOI 10.1001/jama.2018.8907
   Huang F, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/2673763
   Huo Jin, 2017, Zhongguo Zhen Jiu, V37, P1251, DOI 10.13703/j.0255-2930.2017.11.031
   Hyder T, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.713700
   Jung Y, 2018, J BREAST CANCER, V21, P182, DOI 10.4048/jbc.2018.21.2.182
   Kiyomi A, 2015, J CANCER, V6, P367, DOI 10.7150/jca.10695
   Korde LA, 2021, J CLIN ONCOL, V39, P1485, DOI 10.1200/JCO.20.03399
   Li Q., 2017, J HUBEI U TRADIT CHI, V19, P13
   MacPherson H, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000261
   Manyanga T, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-312
   Mendoza TR, 2004, CLIN J PAIN, V20, P357, DOI 10.1097/00002508-200409000-00011
   Morisky DE, 2008, J CLIN HYPERTENS, V10, P348, DOI 10.1111/j.1751-7176.2008.07572.x
   Niravath P, 2013, ANN ONCOL, V24, P1443, DOI 10.1093/annonc/mdt037
   Pan H, 2018, AM J CHINESE MED, V46, P489, DOI 10.1142/S0192415X18500258
   Qi QL, 2022, BIOMED RES INT, V2022, DOI 10.1155/2022/1164355
   Roberts KE, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013167.pub2
   Shi N, 2021, AM J TRANSL RES, V13, P1789
   Soerjomataram I, 2021, NAT REV CLIN ONCOL, V18, P663, DOI 10.1038/s41571-021-00514-z
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Unger JM, 2022, J CLIN ONCOL, V40, P1474, DOI 10.1200/JCO.21.02377
   Wang B., 2016, SHANGHAI J ACUPUNCT, V35, P1429
   Wang X, 2020, THER ADV MED ONCOL, V12, DOI 10.1177/1758835920925991
   Winer EP, 2005, J CLIN ONCOL, V23, P619, DOI 10.1200/JCO.2005.09.121
   Yang JW., 2020, J TRADIT CHIN MED, V42, P1897
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep07835
   Zhang Y., 2021, HEART SURG FORUM, V24
NR 44
TC 0
Z9 0
U1 4
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2023
VL 22
AR 15347354231188679
DI 10.1177/15347354231188679
PG 12
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA O8KC9
UT WOS:001046233500001
PM 37565358
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Liu, W
   Zhang, Y
   Zhu, Q
   Wu, L
AF Liu, Wei
   Zhang, Ying
   Zhu, Qi
   Wu, Lan
TI A scientometric study on research trends and characteristics of burning
   mouth syndrome
SO JOURNAL OF DENTAL SCIENCES
LA English
DT Article
DE Burning mouth syndrome; Bibliometrics; Neurological factors;
   Psychological factors; Therapy strategy
AB Background/purpose: Burning mouth syndrome (BMS) is a chronic condition characterized by intraoral burning sensation and orofacial pain but without oral mucosal lesions. The purpose of this study was to analyze the scientometric characteristics and research trends of BMS. Materials and methods: All the papers on BMS were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2015 and 2015-2024 in the analysis of research trends. Results: There were 924 papers on BMS, with total citations of 24,024 and the h index of 76. The related disorders of BMS were depression, xerostomia, pain, anxiety, glossodynia, taste disorder, nociception, paresthesia, analgesia, sleep disorder, diabetes mellitus, and neuralgia. Clonazepam was most common pharmacotherapy for BMS. After 2015, pharmacologic keywords including drug safety, aripiprazole, duloxetine, folic acid, hydrocortisone, and pregabalin were more frequent. Low level laser therapy, acupuncture, and cognitive behavioral therapy were the emerging nonpharmacologic strategies for BMS. Moreover, laboratory investigations on biomarkers, blood, genetics, interleukin 6, and tumor necrosis factor were more common. Various questionnaires, comorbidity, complication, anemia, hypertension, diabetes mellitus, and sleep were also more concerned after 2015. Conclusion: This scientometric study elucidated the current scenario and research trends of BMS, and would help in improving in reciprocal collaboration and communication for investiga-tions on this condition. <feminine ordinal indicator> 2025 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
C1 [Liu, Wei] Shanghai Ninth Peoples Hosp, Fengcheng Hosp Fengxian Dist, Dept Stomatol, Fengcheng Branch Hosp, Shanghai, Peoples R China.
   [Liu, Wei; Zhu, Qi] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai, Peoples R China.
   [Liu, Wei; Zhang, Ying; Zhu, Qi; Wu, Lan] Shanghai Jiao Tong Univ, Shanghai Res Inst Stomatol, Coll Stomatol, Natl Ctr Stomatol,Natl Clin Res Ctr Oral Dis,Shang, Shanghai, Peoples R China.
   [Zhang, Ying; Wu, Lan] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Oral Mucosal Dis, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University; Shanghai Jiao Tong University
RP Wu, L (corresponding author), Shanghai Ninth Peoples Hosp, Dept Oral Mucosal Dis, 500 Quxi Rd, Shanghai 200011, Peoples R China.; Zhu, Q (corresponding author), Shanghai Ninth Peoples Hosp, Dept Oral & Maxillofacial Head & Neck Oncol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
EM zhuqi70@hotmail.com; teana_wu@sina.com
FU Shanghai Municipal Health Committee [(2021-2023) -0207-01-04, 2022CX009]
FX This work was supported by Shanghai Municipal Health Committee (ZY
   (2021-2023) -0207-01-04, 2022CX009) .
CR Alhendi F, 2023, ORAL DIS, V29, P6, DOI 10.1111/odi.14051
   Alvarenga-Brant R, 2023, J DENT RES, V102, P135, DOI 10.1177/00220345221130025
   de Lima-Souza RA, 2024, OR SURG OR MED OR PA, V137, P119, DOI 10.1016/j.oooo.2023.10.002
   Falagas ME, 2008, FASEB J, V22, P338, DOI 10.1096/fj.07-9492LSF
   Farag AM, 2023, ORAL DIS, V29, P343, DOI 10.1111/odi.13817
   Fernández-Agra M, 2023, ORAL DIS, V29, P2600, DOI 10.1111/odi.14390
   Finfter O, 2024, ORAL DIS, V30, P4668, DOI 10.1111/odi.14900
   Goncalves S, 2023, ORAL DIS, V29, P3016, DOI 10.1111/odi.14297
   Kao CY, 2023, J DENT SCI, V18, P456, DOI 10.1016/j.jds.2022.08.028
   Kong MS, 2024, ORAL DIS, V30, P5360, DOI 10.1111/odi.14959
   Lin XY, 2024, FRONT NEUROL, V15, DOI 10.3389/fneur.2024.1443817
   Liu H, 2023, J DENT SCI, V18, P1883, DOI 10.1016/j.jds.2023.05.016
   Lu CH, 2023, BMC ORAL HEALTH, V23, DOI 10.1186/s12903-023-03441-w
   Lv K, 2024, Int Dent J, DOI [10.1016/j.identj,2024.09.034, DOI 10.1016/J.IDENTJ,2024.09.034]
   Pereira JV, 2021, OR SURG OR MED OR PA, V131, P186, DOI 10.1016/j.oooo.2020.11.019
   Sangalli L, 2024, ORAL DIS, V30, P3761, DOI 10.1111/odi.14914
   Wang GR, 2023, J DENT SCI, V18, P1378, DOI 10.1016/j.jds.2023.03.007
   Wu SS, 2022, ORAL DIS, V28, P1431, DOI 10.1111/odi.13868
   Wu YH, 2023, J DENT SCI, V18, P833, DOI 10.1016/j.jds.2023.01.009
   Zhang Y, 2024, J DENT SCI, V19, P1052, DOI 10.1016/j.jds.2023.06.003
   Zhou ZY, 2024, J DENT SCI, V19, P614, DOI 10.1016/j.jds.2023.06.004
NR 21
TC 0
Z9 0
U1 4
U2 9
PU ELSEVIER TAIWAN
PI TAIPEI
PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2,
   TAIPEI, 10449, TAIWAN
SN 1991-7902
EI 2213-8862
J9 J DENT SCI
JI J. Dental Sci.
PD APR
PY 2025
VL 20
IS 2
BP 1252
EP 1256
DI 10.1016/j.jds.2025.01.009
EA MAR 2025
PG 5
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 0XE9C
UT WOS:001458158500001
PM 40224121
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Badel, T
   Zadravec, D
   Kes, VB
   Smoljan, M
   Lovko, SK
   Zavoreo, I
   Krapac, L
   Milosevic, SA
AF Badel, Tomislav
   Zadravec, Dijana
   Kes, Vanja Basic
   Smoljan, Mia
   Lovko, Sandra Kocijan
   Zavoreo, Iris
   Krapac, Ladislav
   Milosevic, Sandra Anic
TI OROFACIAL PAIN - DIAGNOSTIC AND THERAPEUTIC CHALLENGES
SO ACTA CLINICA CROATICA
LA English
DT Article
DE orofacial pain; temporomandibular joint; anxiety; trigeminal neuralgia
ID TEMPOROMANDIBULAR-JOINT
AB The concept of diagnostics and therapy of musculoskeletal and neuropathic diseases of the stomatognathic system, which are the subject of this paper, has been developing for decades. It can be said that in order to avoid misunderstanding, the orofacial pain as a clinical problem, in the narrower sense, involves non-odontogenic and non-malignant causes of orofacial region. In this study, the results of clinical diagnosis of the population of 557 consecutive patients with orofacial pain based on multidisciplinary diagnostics were evaluated. 15.6% of patients have given up on the participation in the study. It has been shown that the patients who dropped out of the study were significantly older (p=0.0411) than those who agreed to participate, but there was no difference in gender ratio (p=0.185) since the proportion of female patients prevailed. In an analysis of 84.4% of patients participating in the study, the elevated anxiety values were established (mean value on STAI 1 was 39.2 and STAI 2 was 41.1) and statistical significance was found in correlation between elevated anxiety and intensity of pain as shown on visual analogue scale on open mouth (p<0.0001). Compared to the age, the statistical significance was for STAI 1 (p=0.0097) but not for STAI 2 (p=0.5599). The most common form of therapy is Michigan stabilization splint: for disc displacement of temporomandibular joint (TMJ) in 38.9% of patients and in combination with physiotherapy in 18.7% of patients; for osteoarthritis of TMJ in 28.4% and in combination with physiotherapy in 26.4% of patients. The treatment with anticonvulsant drugs for trigeminal neuralgia predominates in 54.3% of patients, which is combined with acupuncture in 25.7% of patients and only acupuncture in 17.1% of patients. In this study, a multidisciplinary co-operation in initial diagnostics and differential was designed to develop subspecialist knowledge on orofacial pain.
C1 [Badel, Tomislav] Univ Zagreb, Sch Dent Med, Dept Removable Prosthodont, Zagreb, Croatia.
   [Zadravec, Dijana; Smoljan, Mia] Univ Zagreb, Sestre Milosrdnice Univ Hosp Ctr, Dept Diagnost & Intervent Radiol, Vinogradska Cesta 29, HR-10000 Zagreb, Croatia.
   [Kes, Vanja Basic; Zavoreo, Iris] Univ Zagreb, Sestre Milosrdnice Univ Hosp Ctr, Dept Neurol, Zagreb, Croatia.
   [Lovko, Sandra Kocijan] Psychiat Hosp Sv Ivan, Zagreb, Croatia.
   [Krapac, Ladislav] Acad Med Sci Croatia, Dept Publ Hlth, Zagreb, Croatia.
   [Milosevic, Sandra Anic] Univ Zagreb, Sch Dent Med, Dept Orthodont, Zagreb, Croatia.
C3 University of Zagreb; University of Zagreb, School of Dental Medicine;
   University of Zagreb; University of Zagreb; University of Zagreb;
   University of Zagreb, School of Dental Medicine
RP Zadravec, D (corresponding author), Univ Zagreb, Sestre Milosrdnice Univ Hosp Ctr, Dept Diagnost & Intervent Radiol, Vinogradska Cesta 29, HR-10000 Zagreb, Croatia.
EM zadravec@sfzg.hr
RI Anic Milosevic, Sana/ADW-5401-2022; Smoljan Basuga, Mia/LTC-9205-2024;
   Badel, Tomislav/AFU-3433-2022; Zadravec, Dijana/JRW-7362-2023
OI Anic Milosevic, Sana/0000-0003-2641-2364; Smoljan Basuga,
   Mia/0000-0002-5996-423X; 
CR Alanen P, 2018, J CRANIOMAND FUNC, V10, P103
   BADEL T, 2007, TEMPOROMANDIBULARNI
   Badel T., 2018, J. Dent. Probl. Solut, V5, P029, DOI [10.17352/2394-8418.000060, DOI 10.17352/2394-8418.000060]
   Badel T, 2017, ACTA CLIN CROAT, V56, P460, DOI 10.20471/acc.2017.56.03.13
   Badel T, 2014, ACTA CLIN CROAT, V53, P462
   Badel T, 2014, ACTA DERMATOVENER CR, V22, P114
   Badel T, 2013, PERIOD BIOL, V115, P185
   Bag AK, 2014, WORLD J RADIOL, V6, P567, DOI 10.4329/wjr.v6.i8.567
   BRAJKOVIC B, 2002, ACTA STOMATOL CROAT, V36, P213
   Canales GD, 2018, J ORAL REHABIL, V45, P881, DOI 10.1111/joor.12685
   Cesarik M, 2017, ACTA CLIN CROAT, V56, P44, DOI 10.20471/acc.2017.56.01.07
   Hladnik A, 2015, PERIOD BIOL, V117, P195
   Jerolimov V., 2009, Medical Sciences, P53
   Karibe H, 2011, CRANIO, V29, P138, DOI 10.1179/crn.2011.022
   Kes VB, 2017, ACTA CLIN CROAT, V56, P157, DOI 10.20471/acc.2017.56.01.21
   Krapac L, 2010, RAD HAZU MED ZNANOST, V34, P97
   Lajnert V, 2009, MEDICINA, V45, P56
   Learreta JA, 2009, CRANIO, V27, P125, DOI 10.1179/crn.2009.019
   Morovic-Vergles J., 2014, MEDIX, V20, P51
   Niemelä K, 2012, J ORAL REHABIL, V39, P799, DOI 10.1111/j.1365-2842.2012.02335.x
   Palla S, 2003, SCHMERZ, V17, P425, DOI 10.1007/s00482-003-0254-6
   Renton Tara, 2019, Prim Dent J, V7, P71, DOI 10.1177/205016841800700414
   Shiloh AR, 2014, ANXIETY DISORDERS RI, P93
   Sklebar D, 2015, PERIOD BIOL, V117, P231
   Spielberger C. D., 2001, PRIRUCNIK UPITNIK AN
   Turp JC, 2017, J Cranio Mand Func, V3, P197
   Turp JC, 2014, J CRANIOMANDIB FUNCT, V6, P231
   Yadav S, 2018, J AM GERIATR SOC, V66, P1213, DOI 10.1111/jgs.15354
NR 28
TC 31
Z9 39
U1 1
U2 22
PU SESTRE MILOSRDNICE UNIV HOSPITAL
PI ZAGREB
PA VINOGRADSKA C 29, ZAGREB, HR-10000, CROATIA
SN 0353-9466
EI 1333-9451
J9 ACTA CLIN CROAT
JI Acta Clin. Croat.
PD JUL
PY 2019
VL 58
SU 1
BP 82
EP 89
DI 10.20471/acc.2019.58.s1.12
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IU1PR
UT WOS:000483348700012
PM 31741564
OA gold
DA 2026-01-16
ER

PT J
AU Soós, SA
   Jeszenoi, N
   Darvas, K
   Harsányi, L
AF Soos Sandor Arpad
   Jeszenoi Norbert
   Darvas Katalin
   Harsanyi Laszlo
TI Attitudes, knowledge and use of complementary and alternative medicine
   among perioperative healthcare professionals
SO ORVOSI HETILAP
LA Hungarian
DT Article
DE nurses; surgery; integrative medicine
ID POSTOPERATIVE PAIN; NURSES ATTITUDES; HERBAL MEDICINES; NATIONAL-SURVEY;
   UNITED-STATES; DOUBLE-BLIND; ACUPUNCTURE; SURGERY; THERAPIES; CANCER
AB Introduction: Perioperative healthcare professionals' attitudes towards non- conventional treatments have not been explored in Hungary yet.
   Aim: Our goal was to survey healthcare professionals' attitude and knowledge towards naturopathy in six clinics of the Semmelweis University that provide perioperative care.
   Method: An anonymous, paper-based questionnaire was used. With an 82% response rate, the data was gained from 119 questionnaires and was processed using statistical analysis and chi-squared test.
   Results: Only 25.2% of those surveyed considered themselves to be well- informed in this field. 68.1% of the participants had an interest in naturopathy and 60.5% would have liked to learn about naturopathy. 70.6% would be willing to use non-conventional treatments in their daily work, predominantly those who have used these methods in the case of their own illness, p = 0.0027. The most popular treatment methods included homeopathy, alternative massage and movement therapy, acupuncture and manual therapy.
   Conclusion: As anticipated based on international literature in this field, those Hungarian healthcare professionals who took part in our survey showed openness and interest towards naturopathy.
C1 [Soos Sandor Arpad; Darvas Katalin; Harsanyi Laszlo] Semmelweis Egyet, Altalanos Orvostud Kar, Sebeszeti Klin 1, Budapest, Hungary.
   [Darvas Katalin] Semmelweis Egyet, Altalanos Orvostud Kar, Aneszteziol & Intenziv Terapias Klin, Budapest, Hungary.
   [Jeszenoi Norbert] Eotvos Lorand Univ, Genet Tanszek, Budapest, Hungary.
   [Jeszenoi Norbert] MTA NAP B Mol Neuroendokrinol Kutatocsoport, Elettani Intezet, Szentagothai Kutatokozpont, Idegtud Kozpont Pecsi Tud Egyet, Pecs, Hungary.
C3 Semmelweis University; Semmelweis University; Eotvos Lorand University;
   University of Pecs
RP Soós, SA (corresponding author), Ulloi Ut 78, H-1082 Budapest, Hungary.
EM soossandormd@gmail.com
RI Jeszenői, Norbert/N-4631-2015
CR Almeida JC, 1996, ANN INTERN MED, V125, P940, DOI 10.7326/0003-4819-125-11-199612010-00023
   American Society of Anesthesiologists, WHAT YOU SHOULD KNOW
   Bahall M, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0610-y
   Barlow T, 2013, COMPLEMENT THER MED, V21, P529, DOI 10.1016/j.ctim.2013.06.008
   Bjerså K, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-42
   Boitor M, 2015, PAIN MANAG NURS, V16, P354, DOI 10.1016/j.pmn.2014.08.014
   Booth-Laforce C, 2010, J PROF NURS, V26, P293, DOI 10.1016/j.profnurs.2010.03.003
   Brown Janis, 2007, Complement Ther Clin Pract, V13, P194, DOI 10.1016/j.ctcp.2007.03.003
   Buchan S., 2012, BR J NURS, V21, P676
   Buchan Shonagh, 2012, Br J Nurs, V21, P672
   Christina J, 2016, ASIA-PAC J ONCOL NUR, V3, P241, DOI 10.4103/2347-5625.189816
   Chu FY, 2007, INT J NURS STUD, V44, P1371, DOI 10.1016/j.ijnurstu.2006.07.001
   Cooke M, 2012, AUST CRIT CARE, V25, P213, DOI 10.1016/j.aucc.2011.12.055
   Damkier A, 1998, SCAND J CARING SCI, V12, P119, DOI 10.1080/02839319850163057
   DeKeyser FG, 2001, J ADV NURS, V36, P41, DOI 10.1046/j.1365-2648.2001.01941.x
   EISENBERG DM, 1993, NEW ENGL J MED, V328, P246, DOI 10.1056/NEJM199301283280406
   Eisenberg DM, 1998, JAMA-J AM MED ASSOC, V280, P1569, DOI 10.1001/jama.280.18.1569
   Ernst E, 2000, B WORLD HEALTH ORGAN, V78, P252
   Giannelli M, 2007, BMC FAM PRACT, V8, DOI 10.1186/1471-2296-8-30
   Hill C F, 1993, Intensive Crit Care Nurs, V9, P116, DOI 10.1016/0964-3397(93)90052-Y
   Holroyd E, 2008, INT J NURS STUD, V45, P1660, DOI 10.1016/j.ijnurstu.2008.04.003
   Horneber M, 2012, INTEGR CANCER THER, V11, P187, DOI 10.1177/1534735411423920
   Jalili J, 2013, PLAST RECONSTR SURG, V131, P168, DOI 10.1097/PRS.0b013e318272f1bb
   Kaye AD, 2000, J CLIN ANESTH, V12, P468, DOI 10.1016/S0952-8180(00)00195-1
   장은희, 2003, [Korean Journal of Adult Nursing, 성인간호학회지], V15, P402
   Leach Matthew J, 2004, Complement Ther Nurs Midwifery, V10, P13, DOI 10.1016/S1353-6117(03)00082-9
   Leung JM, 2001, ANESTH ANALG, V93, P1062, DOI 10.1097/00000539-200110000-00053
   Lindquist Ruth, 2005, Crit Care Nurse, V25, P63
   Lucenteforte E, 2012, EVID-BASED COMPL ALT, V2012, P1, DOI 10.1155/2012/527238
   Malicka I, 2014, MENOPAUSE REV, V13, P221, DOI 10.5114/pm.2014.44997
   Marx W, 2015, CURR OPIN SUPPORT PA, V9, P189, DOI 10.1097/SPC.0000000000000135
   Medical Sciences Section Hungarian Academy of Sciences, 2011, Orv Hetil, V152, P1197, DOI 10.1556/OH.2011.29171
   Mei-Ying Chang, 2004, J Nurs Res, V12, P103
   Melland H I, 2000, Nurse Educ, V25, P247
   Miller J, 2015, ORTHOP NURS, V34, P227, DOI 10.1097/NOR.0000000000000163
   Miller LG, 1998, ARCH INTERN MED, V158, P2200, DOI 10.1001/archinte.158.20.2200
   Noll DR, 2008, J AM OSTEOPATH ASSOC, V108, P508
   Pettersson PH, 2012, J CLIN NURS, V21, P1799, DOI 10.1111/j.1365-2702.2012.04114.x
   Roncada G, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1468-3
   Shorofi Seyed Afshin, 2010, Complement Ther Clin Pract, V16, P229, DOI 10.1016/j.ctcp.2010.05.008
   Shuval J, 2006, SOC SCI MED, V63, P1784, DOI 10.1016/j.socscimed.2006.05.009
   Singer Shepherd R, 2010, BMC Clin Pharmacol, V10, P9, DOI 10.1186/1472-6904-10-9
   Skinner CM, 2002, BRIT J ANAESTH, V89, P792, DOI 10.1093/bja/aef256
   Son H. M., 2001, J KOREAN ACAD FUNDAM, V8, P314
   Soós SA, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1426-0
   Soós SA, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0890-2
   Soós SA, 2015, ORVOSI HETILAP, V156, P1133, DOI 10.1556/650.2015.30132
   Sun Y, 2008, BRIT J ANAESTH, V101, P151, DOI 10.1093/bja/aen146
   Taghavi R, 2013, KOREAN J PAIN, V26, P46, DOI 10.3344/kjp.2013.26.1.46
   Tracy MF, 2005, AM J CRIT CARE, V14, P404
   Tracy MF, 2003, HEART LUNG, V32, P197, DOI 10.1016/S0147-9563(03)00040-2
   Trail-Mahan T, 2013, PAIN MANAG NURS, V14, P277, DOI 10.1016/j.pmn.2011.06.001
   Tsao GJ, 2015, LARYNGOSCOPE, V125, P1972, DOI 10.1002/lary.25252
   Tsen LC, 2000, ANESTHESIOLOGY, V93, P148, DOI 10.1097/00000542-200007000-00025
   Wang Hsiao-Lan, 2004, Pain Manag Nurs, V5, P59, DOI 10.1016/j.pmn.2004.01.002
   Wang SM, 2001, ANESTH ANALG, V93, P1178, DOI 10.1097/00000539-200111000-00024
   Waterbrook AL, 2010, J EMERG MED, V39, P569, DOI 10.1016/j.jemermed.2008.01.007
   Wilkinson J M, 2002, Complement Ther Nurs Midwifery, V8, P142, DOI 10.1054/ctnm.2002.0632
   Yang B, 2014, AFR J TRADIT COMPLEM, V11, P101, DOI 10.4314/ajtcam.v11i4.17
   Yildirim Y, 2010, J CLIN NURS, V19, P1157, DOI 10.1111/j.1365-2702.2009.03188.x
   Yom YH, 2008, J CLIN NURS, V17, P2565, DOI 10.1111/j.1365-2702.2007.02065.x
   Yoshikawa K, 2015, J AM COLL SURGEONS, V221, P571, DOI 10.1016/j.jamcollsurg.2015.03.004
NR 62
TC 1
Z9 1
U1 0
U2 14
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0030-6002
EI 1788-6120
J9 ORVOSI HETILAP
JI Orvosi Hetilap
PD MAR
PY 2017
VL 158
IS 10
BP 368
EP 375
DI 10.1556/650.2017.30676
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EP3NV
UT WOS:000397289900002
PM 28270001
OA hybrid
DA 2026-01-16
ER

PT J
AU Miladinia, M
   Baraz, S
   Shariati, A
   Malehi, AS
AF Miladinia, Mojtaba
   Baraz, Shahram
   Shariati, Abdolali
   Malehi, Amal Saki
TI Effects of Slow-Stroke Back Massage on Symptom Cluster in Adult Patients
   With Acute Leukemia Supportive Care in Cancer Nursing
SO CANCER NURSING
LA English
DT Article
DE Acute leukemia; Chemotherapy; Complementary medicine; Fatigue; Massage
   therapy; Nursing; Pain; Randomized controlled trial; Sleep; Slow-stroke
   back massage
ID RANDOMIZED CONTROLLED-TRIAL; SLEEP DISTURBANCE; THERAPY; FATIGUE;
   COMPLEMENTARY; INTERVENTION; ACUPUNCTURE; MANAGEMENT; DISTRESS; PAIN
AB Background: Patients with acute leukemia usually experience pain, fatigue, and sleep disorders, which affect their quality of life. Massage therapy, as a nondrug approach, can be useful in controlling such problems. However, very few studies have been conducted on the effects of massage therapy on the complications of leukemia. Objective: The aim of this study was to examine the effects of slow-stroke back massage (SSBM) on the symptom cluster in acute leukemia adult patients undergoing chemotherapy. Methods: In this randomized controlled trial, 60 patients with acute leukemia were allocated randomly to either the intervention or control group. The intervention group received SSBM 3 times a week (every other day for 10 minutes) for 4 weeks. The pain, fatigue, and sleep disorder intensities were measured using the numeric rating scale. The sleep quality was measured using the Pittsburgh Sleep Quality Index. Statistical tests of chi(,) t test, and the repeated-measure analysis of variance were used for data analysis. Results: Results showed that the SSBM intervention significantly reduced the progressive sleep disorder, pain, fatigue, and improved sleep quality over time. Conclusions: Slow-stroke back massage, as a simple, noninvasive, and cost-effective approach, along with routine nursing care, can be used to improve the symptom cluster of pain, fatigue, and sleep disorders in leukemia patients. Implications for Practice: Oncology nurses can increase their knowledge regarding this symptom cluster and work to diminish the cluster components by using SSBM in adult leukemia patients.
C1 [Miladinia, Mojtaba; Baraz, Shahram; Shariati, Abdolali] Ahvaz Jundishapur Univ Med Sci, Nursing Care Res Ctr Chron Dis, Sch Nursing & Midwifery, Golestan St, Ahvaz 6135715794, Iran.
   [Malehi, Amal Saki] Ahvaz Jundishapur Univ Med Sci, Dept Biostat & Epidemil, Sch Publ Hlth, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS)
RP Baraz, S (corresponding author), Ahvaz Jundishapur Univ Med Sci, Nursing Care Res Ctr Chron Dis, Sch Nursing & Midwifery, Golestan St, Ahvaz 6135715794, Iran.
EM shahrambaraz@ajums.ac.ir
RI Malehi, Amal/R-8625-2017; Miladinia, Mojtaba/H-3931-2016; shariati,
   abdolali/ABB-5122-2020; Molavynejad, shahram/G-2069-2015; Shariati,
   Abdolali/ABB-5122-2020
OI Miladinia, Mojtaba/0000-0002-6352-7008; shariati,
   abdolali/0000-0002-5851-1618; Molavynejad, shahram/0000-0003-0113-7263;
   Shariati, Abdolali/0000-0001-8113-1894
CR Bao T, 2011, J PAIN SYMPTOM MANAG, V41, P995, DOI 10.1016/j.jpainsymman.2010.08.012
   Barsevick Andrea M, 2007, Semin Oncol Nurs, V23, P89, DOI 10.1016/j.soncn.2007.01.009
   Battaglini CL, 2009, INTEGR CANCER THER, V8, P130, DOI 10.1177/1534735409334266
   Beck SL, 2004, J PAIN SYMPTOM MANAG, V27, P140, DOI 10.1016/j.jpainsymman.2003.12.002
   Bower JE, 2012, J CLIN ONCOL, V30, P4449, DOI 10.1200/JCO.2012.46.0436
   Buysse D J, 1989, Psychiatry Res, V28, P193
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   Clevenger L, 2013, CANCER-AM CANCER SOC, V119, P3234, DOI 10.1002/cncr.28188
   Currin J, 2008, CANCER NURS, V31, P214, DOI 10.1097/01.NCC.0000305725.65345.f3
   Dodd M J, 2001, Oncol Nurs Forum, V28, P465
   Edwards H E, 2001, Nurs Health Sci, V3, P35, DOI 10.1046/j.1442-2018.2001.00069.x
   Erickson JM, 2013, INT J NURS STUD, V50, P847, DOI 10.1016/j.ijnurstu.2012.10.011
   Ernst E, 2009, SUPPORT CARE CANCER, V17, P333, DOI 10.1007/s00520-008-0569-z
   Falkensteiner Maria, 2011, ISRN Nurs, V2011, P929868, DOI 10.5402/2011/929868
   Hajbaghery MA, 2005, BMC HEALTH SERV RES, V5, DOI 10.1186/1472-6963-5-24
   Hasankhani H., 2013, INT RES J APPL BASIC, V4, P3004, DOI [10.1515/jcim-2017-0183, DOI 10.1515/JCIM-2017-0183]
   Holland B, 2001, Rehabil Nurs, V26, P182
   Huang ST, 2010, INT J NURS STUD, V47, P1354, DOI 10.1016/j.ijnurstu.2010.03.008
   Humphreys J., 2008, Middle range theory for nursing, V2nd, P145
   Karagozoglu S, 2013, APPL NURS RES, V26, P210, DOI 10.1016/j.apnr.2013.07.002
   Kashani Fahimeh, 2014, Iran J Nurs Midwifery Res, V19, P113
   Kim HJ, 2005, CANCER NURS, V28, P270
   Kwekkeboom KL, 2012, J PAIN SYMPTOM MANAG, V44, P810, DOI 10.1016/j.jpainsymman.2011.12.281
   Kwekkeboom Kristine L, 2010, Oncol Nurs Forum, V37, pE151, DOI 10.1188/10.ONF.E151-E159
   Lee JS, 2003, ACAD EMERG MED, V10, P1128, DOI 10.1197/S1069-6563(03)00372-5
   Meek S S, 1993, Image J Nurs Sch, V25, P17
   Mehling WE, 2007, J PAIN SYMPTOM MANAG, V33, P258, DOI 10.1016/j.jpainsymman.2006.09.016
   Mok Esther, 2004, Complement Ther Nurs Midwifery, V10, P209, DOI 10.1016/j.ctnm.2004.05.006
   Morrow GR, 2007, ONCOLOGIST, V12, P1, DOI 10.1634/theoncologist.12-S1-1
   Musarezaie Amir, 2014, J Educ Health Promot, V3, P64, DOI 10.4103/2277-9531.134778
   Niggemann B, 2003, ALLERGY, V58, P707, DOI 10.1034/j.1398-9995.2003.00219.x
   Otte JL, 2015, CANCER MED-US, V4, P183, DOI 10.1002/cam4.356
   Post-White Janice, 2003, Integr Cancer Ther, V2, P332, DOI 10.1177/1534735403259064
   Romito F, 2014, EUR J CANCER CARE, V23, P385, DOI 10.1111/ecc.12106
   Rosen G, 2015, SLEEP MED, V16, P503, DOI 10.1016/j.sleep.2014.11.002
   Shinde M.B., 2014, International Journal of Science and Research, V3, P292
   Soltow D, 2010, CANCER NURS, V33, P296, DOI 10.1097/NCC.0b013e3181ce5a1a
   Sudarshan M, 2013, COMPLEMENT THER CLIN, V19, P227, DOI 10.1016/j.ctcp.2013.06.004
   Tas D, 2014, ASIAN PAC J CANCER P, V15, P3139, DOI 10.7314/APJCP.2014.15.7.3139
   Taylor AG, 2009, BRAIN BEHAV IMMUN
   Valeberg BT, 2013, CANCER NURS, V36, P429, DOI 10.1097/NCC.0b013e3182747bcf
   Walters SJ, 2010, J AUST TRADIT-MED SO, V16, P141
   Wesa KM, 2009, EXPERT REV ANTICANC, V9, P1241, DOI 10.1586/ERA.09.100
   Zarea K, 2009, NURS HEALTH SCI, V11, P326, DOI 10.1111/j.1442-2018.2009.00466.x
   Zhou KN, 2015, EUR J ONCOL NURS, V19, P54, DOI 10.1016/j.ejon.2014.07.010
NR 45
TC 43
Z9 50
U1 1
U2 62
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD JAN-FEB
PY 2017
VL 40
IS 1
BP 31
EP 38
DI 10.1097/NCC.0000000000000353
PG 8
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA EG0AH
UT WOS:000390692300010
PM 26925992
DA 2026-01-16
ER

PT J
AU Cassileth, BR
AF Cassileth, Barrie R.
TI Psychiatric benefits of integrative therapies in patients with cancer
SO INTERNATIONAL REVIEW OF PSYCHIATRY
LA English
DT Article
ID QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; COGNITIVE-BEHAVIORAL
   THERAPY; BRIEF HYPNOSIS INTERVENTION; BREAST-CANCER; STRESS REDUCTION;
   PHYSICAL-ACTIVITY; MASSAGE THERAPY; PALLIATIVE CARE; LUNG RESECTION
AB Integrative oncology uses non-pharmacological adjuncts to mainstream care to manage physical, emotional, and psychological symptoms experienced by cancer survivors. Depression, anxiety, fatigue and pain are among the common, often burdensome symptoms that can occur in clusters, deplete patient morale, interfere with treatment plans, and hamper recovery.
   Patients already seek various modalities on their own to address a broad range of problems. Legitimate complementary therapies offered at major cancer institutions improve quality of life, speed recovery, and optimize patient support. They also augment the benefits of psychiatric interventions, due to their ability to increase self-awareness and improve physical and psychological conditioning. Further, these integrated therapies provide lifelong tools and develop skills that patients use well after treatment to develop self-care regimens. The active referral of patients to integrative therapies achieves three important objectives: complementary care is received from therapists experienced in working with cancer patients, visits become part of the medical record, allowing treatment teams to guide individuals in maximizing benefit, and patients are diverted from useless or harmful 'alternatives.'
   We review the reciprocal physical and psychiatric benefits of exercise, mind-body practices, massage, acupuncture, and music therapy for cancer survivors, and suggest how their use can augment mainstream psychiatric interventions.
C1 Mem Sloan Kettering Canc Ctr, Integrat Med Serv, New York, NY 10021 USA.
C3 Memorial Sloan Kettering Cancer Center
RP Cassileth, BR (corresponding author), Mem Sloan Kettering Canc Ctr, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
EM Cassileth@mskcc.org
CR Ahmadi H, 2013, BJU INT, V111, P543, DOI 10.1111/j.1464-410X.2012.11774.x
   Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   Allen JJB, 2006, J CLIN PSYCHIAT, V67, P1665, DOI 10.4088/JCP.v67n1101
   American Cancer Society, 2013, REIK
   Andersen SR, 2013, ACTA ONCOL, V52, P336, DOI 10.3109/0284186X.2012.745948
   Andreescu C, 2011, J CLIN PSYCHIAT, V72, P1129, DOI 10.4088/JCP.10m06105
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], 2013, PALLIAT SUPPORT CARE
   [Anonymous], 2024, LANCET ONCOL, DOI DOI 10.1016/S1470-2045
   Arbane G, 2011, LUNG CANCER, V71, P229, DOI 10.1016/j.lungcan.2010.04.025
   Balboni T, 2011, CANCER-AM CANCER SOC, V117, P5383, DOI 10.1002/cncr.26221
   Binkhorst L, 2013, BREAST CANCER RES TR, V139, P923, DOI 10.1007/s10549-013-2585-z
   Binns-Turner Pamela G, 2011, AANA J, V79, pS21
   Blair SN, 2012, SCAND J MED SCI SPOR, V22, pE24, DOI 10.1111/j.1600-0838.2012.01462.x
   Blumenthal JA, 2007, PSYCHOSOM MED, V69, P587, DOI 10.1097/PSY.0b013e318148c19a
   Blumenthal JA, 2012, J AM COLL CARDIOL, V60, P1053, DOI 10.1016/j.jacc.2012.04.040
   Bobbio A, 2008, EUR J CARDIO-THORAC, V33, P95, DOI 10.1016/j.ejcts.2007.10.003
   Borneman Tami, 2007, J Natl Compr Canc Netw, V5, P1092
   Borneman T, 2010, J PAIN SYMPTOM MANAG, V39, P486, DOI 10.1016/j.jpainsymman.2009.08.007
   Botha D, 2013, CAN J ANESTH, V60, P208, DOI 10.1007/s12630-012-9830-5
   Bower JE, 2012, CANCER-AM CANCER SOC, V118, P3766, DOI 10.1002/cncr.26702
   Bradt J, 2011, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD006911, 10.1002/14651858.CD006911.pub4, 10.1002/14651858.CD006911.pub2]
   Braun LA, 2012, J THORAC CARDIOV SUR, V144, P1453, DOI 10.1016/j.jtcvs.2012.04.027
   Breitbart W, 2012, J CLIN ONCOL, V30, P1304, DOI 10.1200/JCO.2011.36.2517
   Breitbart W, 2011, PSYCHO-ONCOLOGY, V20, P1, DOI 10.1002/pon.1872
   Brown JC, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0030955, 10.1371/journal.pone.0036735]
   Calle EE, 2004, NAT REV CANCER, V4, P579, DOI 10.1038/nrc1408
   Campbell TS, 2012, J BEHAV MED, V35, P262, DOI 10.1007/s10865-011-9357-1
   Carli F, 2012, CAN J ANESTH, V59, P779, DOI 10.1007/s12630-012-9734-4
   Carlson LE, 2004, PSYCHONEUROENDOCRINO, V29, P448, DOI 10.1016/S0306-4530(03)00054-4
   Cassileth BR, 2013, CANCER-AM CANCER SOC, V119, P2455, DOI 10.1002/cncr.28093
   Cassileth BR, 2012, ONCOLOGIST, V17, P590, DOI 10.1634/theoncologist.2012-0149
   CASSILETH BR, 1989, CANCER INVEST, V7, P361, DOI 10.3109/07357908909039864
   Cassileth BR, 2004, ONCOLOGIST, V9, P80, DOI 10.1634/theoncologist.9-1-80
   Cassileth BR, 2004, J PAIN SYMPTOM MANAG, V28, P244, DOI 10.1016/j.jpainsymman.2003.12.016
   Cassileth BR, 2003, CANCER, V98, P2723, DOI 10.1002/cncr.11842
   Chen Z, 2013, CANCER-AM CANCER SOC, V119, P1690, DOI 10.1002/cncr.27904
   Chiesa A, 2013, CLIN PSYCHOL REV, V33, P82, DOI 10.1016/j.cpr.2012.10.006
   Citrin DL, 2012, ONCOLOGIST, V17, P607, DOI 10.1634/theoncologist.2011-0468
   Coats V, 2013, CAN RESPIR J, V20, pE10, DOI 10.1155/2013/291059
   Cohen L, 2004, CANCER-AM CANCER SOC, V100, P2253, DOI 10.1002/cncr.20236
   Craft LL, 2012, CANCER EPIDEM BIOMAR, V21, P3, DOI 10.1158/1055-9965.EPI-11-0634
   Crew KD, 2010, J CLIN ONCOL, V28, P1154, DOI 10.1200/JCO.2009.23.4708
   Cunningham AJ, 1998, PSYCHO-ONCOL, V7, P508, DOI 10.1002/(SICI)1099-1611(199811/12)7:6<508::AID-PON376>3.3.CO;2-Z
   de Raaf PJ, 2013, J CLIN ONCOL, V31, P716, DOI 10.1200/JCO.2012.44.4216
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   DeLoach Walworth Darcy, 2005, J Pediatr Nurs, V20, P276
   Deng G, 2005, CA-CANCER J CLIN, V55, P109, DOI 10.3322/canjclin.55.2.109
   Deng G.E., 2013, CHEST S5, V143, pe420S
   Deng G, 2013, SUPPORT CARE CANCER, V21, P1735, DOI 10.1007/s00520-013-1720-z
   Deng G, 2013, ANN SURG ONCOL, V20, P1164, DOI 10.1245/s10434-012-2759-7
   Desmarais JE, 2009, J CLIN PSYCHIAT, V70, P1688, DOI 10.4088/JCP.08r04856blu
   Dhruva A, 2012, J ALTERN COMPLEM MED, V18, P473, DOI 10.1089/acm.2011.0555
   Docherty SL, 2013, J ADOLESCENT HEALTH, V52, P170, DOI 10.1016/j.jadohealth.2012.05.010
   Doka K.J., 2013, UNDERSTANDING SPIRIT
   Duijts SFA, 2012, J CLIN ONCOL, V30, P4124, DOI 10.1200/JCO.2012.41.8525
   Dusetzina SB, 2013, BREAST CANCER RES TR, V137, P285, DOI 10.1007/s10549-012-2330-z
   Edwards A, 2010, PALLIATIVE MED, V24, P753, DOI 10.1177/0269216310375860
   Elkins G, 2008, J CLIN ONCOL, V26, P5022, DOI 10.1200/JCO.2008.16.6389
   Elkins GR, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-92
   Ernst E, 2009, SUPPORT CARE CANCER, V17, P333, DOI 10.1007/s00520-008-0569-z
   Faber MJ, 2006, ARCH PHYS MED REHAB, V87, P885, DOI 10.1016/j.apmr.2006.04.005
   Fearon KCH, 2008, EUR J CANCER, V44, P1124, DOI 10.1016/j.ejca.2008.02.033
   Feiler Bruce, 2011, Time, V177, P56
   Finnegan-John J, 2013, INTEGR CANCER THER, V12, P276, DOI 10.1177/1534735413485816
   Ford D.W., 2013, CHEST S5, V143
   Geeganage C, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD000323.pub2
   GELLERT GA, 1993, J CLIN ONCOL, V11, P66, DOI 10.1200/JCO.1993.11.1.66
   Gorin SS, 2012, J CLIN ONCOL, V30, P539, DOI 10.1200/JCO.2011.37.0437
   Granger CL, 2013, INTEGR CANCER THER, V12, P213, DOI 10.1177/1534735412450461
   Gulde I, 2011, J PALLIAT CARE, V27, P296, DOI 10.1177/082585971102700406
   Gutgsell KJ, 2013, J PAIN SYMPTOM MANAG, V45, P822, DOI 10.1016/j.jpainsymman.2012.05.008
   Hadi S, 2008, CURR ONCOL, V15, P211
   Hameed KA, 2011, J PEDIAT HEMATOL ONC, V33, pS19, DOI 10.1097/MPH.0b013e3182121a45
   He J. P., 1999, Clinical and Experimental Obstetrics and Gynecology, V26, P81
   Henderson VP, 2013, INTEGR CANCER THER, V12, P404, DOI 10.1177/1534735412473640
   Hilliard RE, 2005, EVID-BASED COMPL ALT, V2, P173, DOI 10.1093/ecam/neh076
   Hodgson NA, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/456897
   Hoffman BM, 2011, PSYCHOSOM MED, V73, P127, DOI 10.1097/PSY.0b013e31820433a5
   Holick CN, 2008, CANCER EPIDEM BIOMAR, V17, P379, DOI 10.1158/1055-9965.EPI-07-0771
   Holland JC, 2010, J NATL COMPR CANC NE, V8, P448, DOI 10.6004/jnccn.2010.0034
   Holmes MD, 2005, JAMA-J AM MED ASSOC, V293, P2479, DOI 10.1001/jama.293.20.2479
   Hovind IL, 2013, J CLIN NURS, V22, P1044, DOI 10.1111/jocn.12167
   Howell D, 2013, CURR ONCOL, V20, pE233, DOI 10.3747/co.20.1302
   Hwang CL, 2012, SUPPORT CARE CANCER, V20, P3169, DOI 10.1007/s00520-012-1452-5
   Irwin ML, 2008, J CLIN ONCOL, V26, P3958, DOI 10.1200/JCO.2007.15.9822
   Jarden M, 2009, BONE MARROW TRANSPL, V43, P725, DOI 10.1038/bmt.2009.27
   Jin Y, 2005, JNCI-J NATL CANCER I, V97, P30, DOI 10.1093/jnci/dji005
   Jones LW, 2007, CANCER-AM CANCER SOC, V110, P590, DOI 10.1002/cncr.22830
   Jones L, 2013, J PAIN SYMPTOM MANAG, V46, P315, DOI 10.1016/j.jpainsymman.2012.08.017
   Jones P, 2013, PSYCHO-ONCOLOGY, V22, P2148, DOI 10.1002/pon.3251
   Kanakura Y, 2002, AM J CHINESE MED, V30, P37, DOI 10.1142/S0192415X02000041
   Kasymjanova G, 2013, CURR ONCOL, V20, P152, DOI 10.3747/co.20.1312
   Kim KH, 2011, DIS COLON RECTUM, V54, P1107, DOI 10.1097/DCR.0b013e318221a934
   Kondryn HJ, 2011, LANCET ONCOL, V12, P100, DOI 10.1016/S1470-2045(10)70069-3
   Ladas EJ, 2006, J PEDIAT HEMATOL ONC, V28, P601, DOI 10.1097/01.mph.0000212989.26317.52
   Lee MS, 2008, INT J CLIN PRACT, V62, P947, DOI 10.1111/j.1742-1241.2008.01729.x
   Lee TI, 2006, AM J CHINESE MED, V34, P37, DOI 10.1142/S0192415X06003618
   Li FZ, 2005, J GERONTOL A-BIOL, V60, P187, DOI 10.1093/gerona/60.2.187
   Lin MR, 2006, PHYS THER, V86, P1189, DOI 10.2522/ptj.20040408
   López-Sendín N, 2012, J ALTERN COMPLEM MED, V18, P480, DOI 10.1089/acm.2011.0277
   Lu WD, 2012, CONTEMP CLIN TRIALS, V33, P700, DOI 10.1016/j.cct.2012.02.017
   Lu WD, 2010, INTEGR CANCER THER, V9, P284, DOI 10.1177/1534735410378856
   Mackereth Peter, 2012, Br J Nurs, V21, pS18
   Magill L, 2008, PSYCHIAT SERV, V59, P1216, DOI 10.1176/appi.ps.59.10.1216
   Marcus DA, 2013, AM J HOSP PALLIAT ME, V30, P216, DOI 10.1177/1049909112469275
   Matecki A.L., 2009, ACUPUNCTURE SAFETY
   Melchart D, 2004, ARCH INTERN MED, V164, P104, DOI 10.1001/archinte.164.1.104
   Memorial Sloan-Kettering Cancer Center, 2013, MED MASS CANC PAT 1
   Memorial Sloan-Kettering Cancer Center, 2013, INT MED HOM TOOLS
   Milani RV, 2011, AM J CARDIOL, V107, P64, DOI 10.1016/j.amjcard.2010.08.047
   Mishra SI, 2012, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD007566.pub2, 10.1002/14651858.CD008465.pub2]
   Molassiotis A, 2007, COMPLEMENT THER MED, V15, P3, DOI 10.1016/j.ctim.2006.07.005
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Montgomery GH, 2007, JNCI-J NATL CANCER I, V99, P1304, DOI 10.1093/jnci/djm106
   Montgomery GH, 2010, J CONSULT CLIN PSYCH, V78, P80, DOI 10.1037/a0017392
   Montgomery GH, 2009, HEALTH PSYCHOL, V28, P317, DOI 10.1037/a0013582
   Mustian Karen M, 2012, Oncol Hematol Rev, V8, P81
   National Cancer Institute, 2013, OB CANC RISK FACT SH
   National Cancer Institute, 2013, CANC SURV RES SURV D
   National Center for Complementary and Alternative Medicine, 2013, EN MED OV
   National Comprehensive Cancer Network, 2013, NCCN GUID SUPP CAR V
   Navarro M., 2012, 9 INT C SOC INT ONC
   Oh B, 2010, ANN ONCOL, V21, P608, DOI 10.1093/annonc/mdp479
   Oh B, 2012, SUPPORT CARE CANCER, V20, P1235, DOI 10.1007/s00520-011-1209-6
   Oldervoll LM, 2011, ONCOLOGIST, V16, P1649, DOI 10.1634/theoncologist.2011-0133
   Paley CA, 2011, PHYSIOTHERAPY, V97, P256, DOI 10.1016/j.physio.2010.08.008
   Peppone LJ, 2013, J CLIN ONCOL, V31
   Pfister DG, 2010, J CLIN ONCOL, V28, P2565, DOI 10.1200/JCO.2009.26.9860
   Puterman E, 2011, PSYCHOSOM MED, V73, P604, DOI 10.1097/PSY.0b013e318229e1e0
   Ramondetta LM, 2013, SUPPORT CARE CANCER, V21, P2991, DOI 10.1007/s00520-013-1863-y
   Richmond J, 1996, JAMA-J AM MED ASSOC, V276, P313
   Riesenberg H, 2010, SUPPORT CARE CANCER, V18, P877, DOI 10.1007/s00520-009-0727-y
   Schmitz KH, 2010, MED SCI SPORT EXER, V42, P1409, DOI 10.1249/MSS.0b013e3181e0c112
   Schnur Julie B, 2008, Contemp Hypn, V25, P114, DOI 10.1002/ch.364
   Schnur JB, 2009, J CLIN PSYCHOL, V65, P443, DOI 10.1002/jclp.20559
   Schreiber KL, 2013, PAIN, V154, P660, DOI 10.1016/j.pain.2012.11.015
   Selman LE, 2012, EUR J CANCER CARE, V21, P87, DOI 10.1111/j.1365-2354.2011.01285.x
   Shapiro SL, 2003, J PSYCHOSOM RES, V54, P85, DOI 10.1016/S0022-3999(02)00546-9
   Sharp DM, 2010, EUR J CANCER, V46, P312, DOI 10.1016/j.ejca.2009.10.006
   Silver JK, 2013, AM J PHYS MED REHAB, V92, P715, DOI 10.1097/PHM.0b013e31829b4afe
   Simcock R, 2013, ANN ONCOL, V24, P776, DOI 10.1093/annonc/mds515
   Society for Integrative Oncology, 2009, EV BAS CLIN PRACT GU
   Stafford L, 2013, SUPPORT CARE CANCER, V21, P3009, DOI 10.1007/s00520-013-1880-x
   Stephenson NLN, 2007, ONCOL NURS FORUM, V34, P127, DOI 10.1188/07.ONF.127-132
   Streeter CC, 2012, MED HYPOTHESES, V78, P571, DOI 10.1016/j.mehy.2012.01.021
   Tipples K, 2011, DRUG AGING, V28, P867, DOI 10.2165/11595820-000000000-00000
   Toth M, 2013, J ALTERN COMPLEM MED, V19, P650, DOI 10.1089/acm.2012.0466
   Tsang HWH, 2013, AGING MENT HEALTH, V17, P336, DOI 10.1080/13607863.2012.732035
   Tsay SL, 2008, CANCER NURS, V31, P109, DOI 10.1097/01.NCC.0000305694.74754.7b
   Tsivian M, 2012, UROLOGY, V79, P32, DOI 10.1016/j.urology.2011.09.037
   Vesey Siobhan, 2013, Br J Community Nurs, VSuppl, pS18
   Virgo KS, 2013, J CLIN ONCOL, V31, P2322, DOI 10.1200/JCO.2012.45.6954
   Walker EM, 2010, J CLIN ONCOL, V28, P634, DOI 10.1200/JCO.2009.23.5150
   Wang SM, 2008, ANESTH ANALG, V107, P811, DOI 10.1213/ane.0b013e3181804441
   Wang SM, 2007, J ALTERN COMPLEM MED, V13, P241, DOI 10.1089/acm.2006.6262
   Wang SM, 2005, ANESTH ANALG, V101, P666, DOI 10.1213/01.ANE.0000175212.17642.45
   Wilkinson S, 2008, J ADV NURS, V63, P430, DOI 10.1111/j.1365-2648.2008.04712.x
   Wilkinson SM, 2007, J CLIN ONCOL, V25, P532, DOI 10.1200/JCO.2006.08.9987
   Witt CM, 2009, FORSCH KOMPLEMENTMED, V16, P91, DOI 10.1159/000209315
   Würtzen H, 2013, EUR J CANCER, V49, P1365, DOI 10.1016/j.ejca.2012.10.030
   Wyatt G, 2007, ONCOL NURS FORUM, V34, P635, DOI 10.1188/07.ONF.635-642
   Wyatt G, 2012, ONCOL NURS FORUM, V39, P568, DOI 10.1188/12.ONF.568-577
NR 163
TC 10
Z9 14
U1 0
U2 46
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-0261
EI 1369-1627
J9 INT REV PSYCHIATR
JI Int. Rev. Psych.
PD FEB
PY 2014
VL 26
IS 1
BP 114
EP 127
DI 10.3109/09540261.2013.838153
PG 14
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA AB9QJ
UT WOS:000332130100010
PM 24716505
DA 2026-01-16
ER

PT J
AU Poo, CL
   Dewadas, HD
   Ng, FL
   Foo, CN
   Lim, YM
AF Poo, Chin Long
   Dewadas, Hemaniswarri Dewi
   Ng, Foong Leng
   Foo, Chai Nien
   Lim, Yang Mooi
TI Effect of Traditional Chinese Medicine on Musculoskeletal Symptoms in
   Breast Cancer: A Systematic Review and Meta-Analysis
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Review
DE Traditional Chinese Medicine (TCM); breast cancer; aromatase
   inhibitor-associated musculoskeletal symptoms (AIMSS); systematic
   review; meta-analysis
ID POSTMENOPAUSAL WOMEN; OSTEOARTHRITIS INDEX; TAMOXIFEN THERAPY;
   RANDOMIZED-TRIAL; WESTERN-ONTARIO; SHORT-FORM; BRIEF PAIN; OSTEOPOROSIS;
   RELIABILITY; ACUPUNCTURE
AB Context. Traditional Chinese Medicine (TCM) has been widely used as a complementary medical treatment for arthralgia and other types of pain. The available literature on the effectiveness of TCM on breast cancer patients with musculoskeletal symptoms reports controversial results. Objectives. The objective of this review is to assess the effectiveness of TCM as a treatment option for musculoskeletal symptoms in patients with breast cancer who were treated with aromatase inhibitors (AIs). Methods. A comprehensive literature search was conducted using PubMed, the Cochrane Library, SAGE journals, Scopus, EMBASE, Web of Science, Medline, Cumulated Index to Nursing and Allied Health Literature (CINAHL), Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), Wanfang, and Chinese Medical Journal Database (CMJ) from May 2020 to November 2020. The literature review included randomized controlled trials (RCTs) of TCM for AI-related musculoskeletal symptoms. Results. Four RCTs incorporating TCM were assessed by meta-analysis and reported favorable effects in reducing worst pain score (n = 284, mean difference [MD]: 2.31; 95% CI, 1.74 to 2.88; P < 0.00001). Three trials showed favorable effects of TCM in reducing pain interference (n = 211, MD: 2.62; 95% CI, 1.29 to 3.94; P= 0.0001), while two trials reported no significant effects of TCM on stiffness (n = 147, MD: 1.21; 95% CI, -0.39 to 2.82; P= 0.14). The meta-analysis of three trials also found no significant effect of TCM on bone mineral density (n = 214, MD, -0.01; 95% CI, -0.07 to 0.05; P= 0.71). The physical aspect of quality of life was significantly increased in breast cancer patients after TCM treatment (n = 220, MD, 5.13; 95% CI, 2.04 to 8.22; P = 0.001). In addition, three RCTs reported minimal TCM-related adverse events. Conclusion. The results suggest that TCM could be an effective treatment in relieving pain especially worst pain and pain interference as well as improving quality of life caused by AI-related musculoskeletal symptoms. However, further investigation of the molecular pathway involved and in-depth safety profile are needed. J Pain Symptom Manage 2021;62:159e173. (c) 2020 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Poo, Chin Long; Dewadas, Hemaniswarri Dewi; Ng, Foong Leng; Foo, Chai Nien; Lim, Yang Mooi] Univ Tunku Abdul Rahman, Ctr Canc Res, Fac Med & Hlth Sci, Jalan Sungai Long, Kajang, Selangor, Malaysia.
   [Ng, Foong Leng] Univ Tunku Abdul Rahman, Dept Chinese Med, Fac Med & Hlth Sci, Jalan Sungai Long, Kajang, Selangor, Malaysia.
   [Foo, Chai Nien] Univ Tunku Abdul Rahman, Dept Populat Med, Fac Med & Hlth Sci, Jalan Sungai Long, Kajang, Selangor, Malaysia.
   [Lim, Yang Mooi] Univ Tunku Abdul Rahman, Dept Preclin Sci, Fac Med & Hlth Sci, Jalan Sungai Long, Kajang, Selangor, Malaysia.
C3 Universiti Tunku Abdul Rahman (UTAR); Universiti Tunku Abdul Rahman
   (UTAR); Universiti Tunku Abdul Rahman (UTAR); Universiti Tunku Abdul
   Rahman (UTAR)
RP Lim, YM (corresponding author), Univ Tunku Abdul Rahman, Dept Preclin Sci, Fac Med & Hlth Sci, Ctr Canc Res, Jalan Sungai Long, Kajang 43000, Selangor, Malaysia.
EM ymlim@utar.edu.my
RI Dewadas, Hemaniswarri Dewi/A-5493-2019; Foong Leng, Ng/T-6716-2017; LIM,
   YANG MOOI/J-1311-2014; FOO, CHAINIEN/ABW-8479-2022
OI Dewadas, Hemaniswarri Dewi/0000-0002-6851-1574; LIM, YANG
   MOOI/0000-0003-1377-7655; FOO, CHAINIEN/0000-0003-0362-6394
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
   [Anonymous], BREAST CANCER-TOKYO
   Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
   Baum M, 2002, LANCET, V359, P2131
   Boccardo F, 2005, J CLIN ONCOL, V23, P5138, DOI 10.1200/JCO.2005.04.120
   Coates AS, 2007, J CLIN ONCOL, V25, P486, DOI 10.1200/JCO.2006.08.8617
   Coombes RC, 2004, NEW ENGL J MED, V350, P1081, DOI 10.1056/NEJMoa040331
   Crew Katherine D, 2007, J Cancer Surviv, V1, P283, DOI 10.1007/s11764-007-0034-x
   Darby Susan B, 2009, Nurs Womens Health, V13, P198, DOI 10.1111/j.1751-486X.2009.01420.x
   Gandek B, 2015, ARTHRIT CARE RES, V67, P216, DOI 10.1002/acr.22415
   Gao Huimin, 2011, Front Med, V5, P195, DOI 10.1007/s11684-011-0134-x
   Goss PE, 2003, NEW ENGL J MED, V349, P1793, DOI 10.1056/NEJMoa032312
   Hawker GA, 2011, ARTHRIT CARE RES, V63, pS240, DOI 10.1002/acr.20543
   He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
   Henry NL, 2012, J CLIN ONCOL, V30, P936, DOI 10.1200/JCO.2011.38.0261
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Honma N, 2019, SUPPORT CARE CANCER, V27, P3813, DOI 10.1007/s00520-019-04674-8
   Li JY, 2017, CLIN INTERV AGING, V12, P45, DOI 10.2147/CIA.S117597
   Li YF, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/2478565
   Liu WG, 2013, J HENAN UNI CHIN MED
   Lombard JM, 2016, SUPPORT CARE CANCER, V24, P2139, DOI 10.1007/s00520-015-3001-5
   Macdonald G, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001930.pub3
   Mendoza T, 2006, EUR J PAIN, V10, P353, DOI 10.1016/j.ejpain.2005.06.002
   Muslimani AA, 2009, CLIN BREAST CANCER, V9, P34, DOI 10.3816/CBC.2009.n.006
   Peng N, 2018, BREAST, V37, P18, DOI 10.1016/j.breast.2017.08.003
   Pineda-Moncusí M, 2019, BREAST CANCER RES TR, V177, P53, DOI 10.1007/s10549-019-05289-7
   Salaffi F, 2003, OSTEOARTHR CARTILAGE, V11, P551, DOI 10.1016/S1063-4584(03)00089-X
   Suskin J, 2018, GLAND SURG, V7, P411, DOI 10.21037/gs.2018.07.05
   Victorson D, 2008, QUAL LIFE RES, V17, P1137, DOI 10.1007/s11136-008-9398-2
   Wang XS, 1996, PAIN, V67, P407, DOI 10.1016/0304-3959(96)03147-8
   Winer EP, 2005, J CLIN ONCOL, V23, P619, DOI 10.1200/JCO.2005.09.121
   Xu L, 2007, INTEGR CANCER THER, V6, P208, DOI 10.1177/1534735407305705
   Xue Jing-Xian, 2018, Evid Based Complement Alternat Med, V2018, P6305645, DOI 10.1155/2018/6305645
   Ye J., 2015, Shanghai J Acup Moxib, V34, P642
   Zhong Y., 2017, THESIS GUANGZHOU U C
   Zhu LB, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/9469276
NR 36
TC 14
Z9 17
U1 3
U2 41
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD JUL
PY 2021
VL 62
IS 1
BP 159
EP 173
DI 10.1016/j.jpainsymman.2020.11.024
EA JUN 2021
PG 15
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA SW8AB
UT WOS:000664736200021
PM 33278502
DA 2026-01-16
ER

PT J
AU Cheng, XL
   Liu, HQ
   Wang, Q
   Huo, JG
   Wang, XN
   Cao, P
AF Cheng, Xiao L.
   Liu, Hong Q.
   Wang, Qi
   Huo, Jie G.
   Wang, Xiao N.
   Cao, Peng
TI Chemotherapy-induced peripheral neurotoxicity and complementary and
   alternative medicines: progress and perspective
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE chemotherapy-induced peripheral neurotoxicity; complementary and
   alternative medicine; herbal medicine; acupuncture; Pathogenesis
ID OXALIPLATIN-RELATED NEUROTOXICITY; NEUROPATHIC PAIN; ALCOHOLIC
   NEUROPATHY; DIABETIC-NEUROPATHY; DRUG TRANSPORTERS; PACLITAXEL; CANCER;
   VINCRISTINE; CURCUMIN; EXTRACT
AB Chemotherapy-induced peripheral neurotoxicity (CIPN) is a severe and dose-limiting side effect of antineoplastic drugs. It can cause sensory, motor and autonomic system dysfunction, and ultimately force patients to discontinue chemotherapy. Until now, little is understood about CIPN and no consistent caring standard is available. Since CIPN is a multifactorial disease, the clinical efficacy of single pharmacological drugs is disappointing, prompting patients to seek alternative treatment options. Complementary and alternative medicines (CAMs), especially herbal medicines, are well known for their multifaceted implications and widely used in human health care. Up to date, several phytochemicals, plant extractions, and herbal formulas have been evaluated for their potential therapeutic benefit of preventing the onset and progression of CIPN in experimental models. Clinical acupuncture has also been shown to improve CIPN symptoms. In this review, we will give an outline of our current knowledge regrading the advanced research of CIPN, the role of CAMs in alleviating CIPN and possible lacunae in research that needs to be addressed.
C1 [Cheng, Xiao L.; Liu, Hong Q.; Huo, Jie G.; Wang, Xiao N.; Cao, Peng] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing, Jiangsu, Peoples R China.
   [Cheng, Xiao L.; Cao, Peng] Jiangsu Prov Acad Tradit Chinese Med, Lab Cellular & Mol Biol, Nanjing, Jiangsu, Peoples R China.
   [Wang, Qi] Jiangsu Shenlong Pharmaceut Co Ltd, Yancheng, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Cao, P (corresponding author), Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing, Jiangsu, Peoples R China.
EM pcao79@yahoo.com
RI , Peng/HTL-5606-2023; Cao, Peng/AGT-2878-2022; Wang,
   Xiaoning/ODL-4589-2025; huo, jiege/HKM-3928-2023
OI , Peng/0000-0002-2044-3074; 
FU National Natural Science Foundation of China [81403092, 81473377,
   81274150, 81573665]; Foundation for Distinguished Young Scholars of
   Jiangsu Province [BK20140049]
FX This study received support from National Natural Science Foundation of
   China (NO.81403092, NO.81473377, NO. 81274150, NO. 81573665), and was
   also funded by grants from Science Foundation for Distinguished Young
   Scholars of Jiangsu Province (No. BK20140049).
CR Abad A. Namvaran Abbas, 2011, Chinese Journal of Natural Medicines, V9, P126, DOI 10.3724/SP.J.1009.2011.00126
   Akira S, 2004, NAT REV IMMUNOL, V4, P499, DOI 10.1038/nri1391
   Al Moundhri MS, 2013, J MED TOXICOL, V9, P25, DOI 10.1007/s13181-012-0239-x
   Alessandri-Haber N, 2008, J NEUROSCI, V28, P1046, DOI 10.1523/JNEUROSCI.4497-07.2008
   Ameyaw EO, 2014, PHARMACOGN RES, V6, P172, DOI 10.4103/0974-8490.129041
   Anand U, 2010, MOL PAIN, V6, DOI 10.1186/1744-8069-6-82
   Andoh Tsugunobu, 2014, J Tradit Complement Med, V4, P293, DOI 10.4103/2225-4110.128906
   Argyriou AA, 2014, CANCER MANAG RES, V6, P135, DOI 10.2147/CMAR.S44261
   Argyriou AA, 2013, CANCER-AM CANCER SOC, V119, P3570, DOI 10.1002/cncr.28234
   Ataie A, 2010, PHARMACOL BIOCHEM BE, V96, P378, DOI 10.1016/j.pbb.2010.06.009
   Attia HN, 2012, BEHAV PHARMACOL, V23, P153, DOI 10.1097/FBP.0b013e3283512c00
   Azevedo MI, 2013, MOL PAIN, V9, DOI 10.1186/1744-8069-9-53
   Bahar MK, 2013, ADV HIGH ENERGY PHYS, V2013, DOI 10.1155/2013/814985
   Bennett GJ, 2011, EUR J NEUROSCI, V33, P1667, DOI 10.1111/j.1460-9568.2011.07652.x
   Boyette-Davis J, 2011, PAIN, V152, P308, DOI 10.1016/j.pain.2010.10.030
   Broyl A, 2010, LANCET ONCOL, V11, P1057, DOI 10.1016/S1470-2045(10)70206-0
   Carozzi VA, 2015, NEUROSCI LETT, V596, P90, DOI 10.1016/j.neulet.2014.10.014
   Cassileth BR, 2007, CHEST, V132, p340S, DOI 10.1378/chest.07-1389
   Cavaletti G, 2014, ANTICANCER RES, V34, P483
   Cavaletti G, 2011, ONCOLOGIST, V16, P1667, DOI 10.1634/theoncologist.2011-0343
   Ceresa C, 2011, CURR MED CHEM, V18, P329, DOI 10.2174/092986711794839160
   Ciarimboli G, 2010, AM J PATHOL, V176, P1169, DOI 10.2353/ajpath.2010.090610
   Dean-Clower E, 2010, INTEGR CANCER THER, V9, P158, DOI 10.1177/1534735409360666
   Fidanboylu M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025212
   Flatters SJL, 2006, NEUROSCI LETT, V397, P219, DOI 10.1016/j.neulet.2005.12.013
   Flatters SJL, 2004, PAIN, V109, P150, DOI 10.1016/j.pain.2004.01.029
   Florea Ana-Maria, 2011, Cancers (Basel), V3, P1351, DOI 10.3390/cancers3011351
   Gamelin L, 2008, J CLIN ONCOL, V26, P1188, DOI 10.1200/JCO.2007.15.3767
   Gauchan P, 2009, NEUROSCI LETT, V458, P93, DOI 10.1016/j.neulet.2009.04.029
   Gauchan P, 2009, BIOL PHARM BULL, V32, P732, DOI 10.1248/bpb.32.732
   Gobran NS., 2013, Chinese-German J Clin Oncol, V12, P232, DOI DOI 10.1007/S10330-013-1161-7
   Goswami C, 2012, J NEUROCHEM, V123, P1, DOI 10.1111/j.1471-4159.2012.07892.x
   Han YQ, 2013, FRONT PHARMACOL, V4, DOI 10.3389/fphar.2013.00156
   Hara T, 2013, PAIN, V154, P882, DOI 10.1016/j.pain.2013.02.023
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Hutchinson MR, 2008, EUR J NEUROSCI, V28, P20, DOI 10.1111/j.1460-9568.2008.06321.x
   Jaggi AS, 2012, TOXICOLOGY, V291, P1, DOI 10.1016/j.tox.2011.10.019
   Kandhare AD, 2012, NEUROSCI LETT, V511, P18, DOI 10.1016/j.neulet.2012.01.019
   Kaur G, 2010, J BRACHIAL PLEX PERI, V5, DOI 10.1186/1749-7221-5-3
   Kim HK, 2010, ANESTHESIOLOGY, V112, P432, DOI 10.1097/ALN.0b013e3181ca31bd
   Ko J, 2002, J BIOCHEM MOL BIOL, V35, P420
   Kono T, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nep200
   Leal AD, 2014, CANCER-AM CANCER SOC, V120, P1890, DOI 10.1002/cncr.28654
   Ledeboer A, 2007, BRAIN BEHAV IMMUN, V21, P686, DOI 10.1016/j.bbi.2006.10.012
   Lee JS, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-124
   Litscher G, 2002, LASER MED SCI, V17, P19, DOI 10.1007/s10103-002-8262-9
   Liu YF, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/541217
   Loprinzi CL, 2014, J CLIN ONCOL, V32, P997, DOI 10.1200/JCO.2013.52.0536
   Mangiacavalli S, 2010, BRIT J HAEMATOL, V149, P916, DOI 10.1111/j.1365-2141.2010.08138.x
   Mannelli LD, 2012, J PAIN, V13, P276, DOI 10.1016/j.jpain.2011.11.009
   Melli G, 2008, EXP NEUROL, V214, P276, DOI 10.1016/j.expneurol.2008.08.013
   Mendonça LM, 2013, NEUROTOXICOLOGY, V34, P205, DOI 10.1016/j.neuro.2012.09.011
   Miltenburg NC, 2014, CANCER TREAT REV, V40, P872, DOI 10.1016/j.ctrv.2014.04.004
   Mizuno K, 2014, J PHARMACOL SCI, V125, P91, DOI 10.1254/jphs.13244FP
   Nativi C, 2013, SCI REP-UK, V3, DOI 10.1038/srep02005
   Negi G, 2011, CURR NEUROVASC RES, V8, P294, DOI 10.2174/156720211798120972
   Nishioka M, 2011, INT J CLIN ONCOL, V16, P322, DOI 10.1007/s10147-010-0183-1
   Öztürk G, 2004, TOXICOL APPL PHARM, V196, P169, DOI 10.1016/j.taap.2003.12.006
   Park HJ, 2012, ANESTH ANALG, V115, P1228, DOI 10.1213/ANE.0b013e318262e170
   Park JH, 2010, BRAIN RES, V1322, P24, DOI 10.1016/j.brainres.2010.02.001
   Podratz JL, 2011, NEUROBIOL DIS, V41, P661, DOI 10.1016/j.nbd.2010.11.017
   Polomano RC, 2001, PAIN, V94, P293, DOI 10.1016/S0304-3959(01)00363-3
   Quartu M, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/180428
   Nieto FR, 2008, PAIN, V137, P520, DOI 10.1016/j.pain.2007.10.012
   Raygude Kiran S., 2012, Inflammopharmacology, V20, P331, DOI 10.1007/s10787-012-0122-z
   Salat K, 2013, CURR MED CHEM, V20, P1409, DOI 10.2174/09298673113209990107
   Sandireddy R, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/674987
   Schäfers M, 2008, NEUROSCI LETT, V437, P188, DOI 10.1016/j.neulet.2008.03.052
   Schroeder S, 2012, ACUPUNCT MED, V30, P4, DOI 10.1136/acupmed-2011-010034
   Shabani M, 2012, NEUROTOXICOLOGY, V33, P1314, DOI 10.1016/j.neuro.2012.08.004
   Silva JRT, 2011, J PAIN, V12, P51, DOI 10.1016/j.jpain.2010.04.008
   Sittl R, 2012, P NATL ACAD SCI USA, V109, P6704, DOI 10.1073/pnas.1118058109
   Sprowl JA, 2013, P NATL ACAD SCI USA, V110, P11199, DOI 10.1073/pnas.1305321110
   Ta LE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054161
   Ta LE, 2010, MOL PAIN, V6, DOI 10.1186/1744-8069-6-15
   Thiagarajan VRK, 2013, TOXICOL IND HEALTH, V29, P3, DOI 10.1177/0748233711432573
   Uno T, 2005, DIABETES RES CLIN PR, V69, P129, DOI 10.1016/j.diabres.2004.11.017
   Ushio S, 2012, EUR J CANCER, V48, P1407, DOI 10.1016/j.ejca.2011.08.009
   Wagner K, 2011, J AGR FOOD CHEM, V59, P2816, DOI 10.1021/jf102559q
   Wang Hong-tao, 2011, Zhonghua Xue Ye Xue Za Zhi, V32, P107
   Wang JR, 2008, BIOL PHARM BULL, V31, P643, DOI 10.1248/bpb.31.643
   Wang YK, 2013, SCI REP-UK, V3, DOI [10.1038/srep01864, 10.1038/srep02490]
   Waseem M, 2016, PROTOPLASMA, V253, P417, DOI 10.1007/s00709-015-0821-6
   Webster RG, 2005, BRIT J PHARMACOL, V146, P1027, DOI 10.1038/sj.bjp.0706407
   Wolf G, 2006, PAIN, V120, P315, DOI 10.1016/j.pain.2005.11.011
   Wolf S, 2008, EUR J CANCER, V44, P1507, DOI 10.1016/j.ejca.2008.04.018
   Xiao WH, 2012, PAIN, V153, P704, DOI 10.1016/j.pain.2011.12.011
   Xu Wei-Ru, 2010, Zhongguo Zhen Jiu, V30, P457
   Yamamoto Tomoya, 2009, Gan To Kagaku Ryoho, V36, P89
   Yerra VG, 2013, REDOX BIOL, V1, P394, DOI 10.1016/j.redox.2013.07.005
   Zaveri NT, 2006, LIFE SCI, V78, P2073, DOI 10.1016/j.lfs.2005.12.006
   Zhang YY, 2014, BASIC RES CARDIOL, V109, DOI 10.1007/s00395-014-0407-z
   Zheng H, 2012, EXP NEUROL, V238, P225, DOI 10.1016/j.expneurol.2012.08.023
NR 93
TC 29
Z9 36
U1 0
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 23
PY 2015
VL 6
AR 234
DI 10.3389/fphar.2015.00234
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CX9UO
UT WOS:000366051400002
PM 26557088
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Aljawadi, MH
   Khoja, AT
   AlOtaibi, AD
   Alharbi, KT
   Alodayni, MA
   AlMetwazi, MS
   Arafah, A
   Al-Shammari, SA
   Khoja, TA
AF Aljawadi, Mohammad H.
   Khoja, Abdullah T.
   AlOtaibi, Azzam D.
   Alharbi, Khalid Turki
   Alodayni, Muhannad Abdulwahed
   AlMetwazi, Mansour S.
   Arafah, Azher
   Al-Shammari, Sulaiman A.
   Khoja, Tawfik A.
TI The Utilization of Complementary and Alternative Medicine among Saudi
   Older Adults: A Population-Based Study
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID PATIENT-PHYSICIAN RELATIONSHIP; SUBJECTIVE COGNITIVE DECLINE;
   QUALITY-OF-LIFE; HERBAL MEDICINES; CANCER-PATIENTS; UNITED-STATES;
   BREAST-CANCER; DRUG-INTERACTIONS; CHRONIC DISEASES; CONTROLLED-TRIAL
AB Background. Complementary and alternative medicine (CAM) is an integral part of patients' therapeutic experience worldwide. Among Saudi older adults, less is known about CAM utilization. Objectives. To determine the prevalence, patterns, and factors associated with CAM utilization among SOA. Methods. In the Saudi National Survey for Elderly Health (SNSEH), subjects were asked about CAM use during the last twelve months before the interview. CAM use was defined as any use of herbal products, acupuncture, bloodletting, cauterization, medical massage, bones manual manipulation, honey, or religious rituals. Demographic characteristics included gender, age, marital status, region, educational level, and residence area. In addition, multiple comorbidities were included as possible factors that may be associated with CAM use. Multivariable logistic regression was used to explore factors associated with CAM utilization. All statistical analyses were done using STATA v.14. Results. Out of 2946 respondents, 50.4% were males, the mean age was 70.3 +/- 8.3 years, and 70% were illiterate. CAM use was prevalent (62.5%). The most common CAM types were herbal products (25.4%), acupuncture (21.2%), bloodletting (12%), honey (9.5%), cauterization (7.4%), medical massage and bones manual manipulation (4%), and traditional bone setting (2.1%). In the multivariable regression, age, gender, and marital status did not have an impact on the odds of using CAM. Subjects from rural areas were 2.92 times more likely to use CAM compared with subjects in urban areas (OR = 2.92; 95%CI: 2.28-3.75). Subjects with metabolic disorders (OR = 0.50; 95% CI: 0.42-0.60) or kidney disease were less likely to use CAM (OR = 0.30; 95%CI: 0.14-0.64). About pain, CAM is used more in neck pain (OR = 1.69; 95%CI: 1.30-2.21) and also used in back pain (OR = 1.22; 95%CI: 1.03-1.46). Conclusions. CAM use was very prevalent among SOA. Clinicians and pharmacists must ask about CAM use among older adults as many of CAM may interact with patients medications.
C1 [Aljawadi, Mohammad H.; AlMetwazi, Mansour S.; Arafah, Azher] King Saud Univ, Coll Pharm, Dept Clin Pharm, Riyadh, Saudi Arabia.
   [Khoja, Abdullah T.] Al Imam Muhammad Ibn Saud Islamic Univ IMSIU, Coll Med, Publ Hlth Dept, Riyadh, Saudi Arabia.
   [Khoja, Abdullah T.] Al Imam Muhammad Ibn Saud Islamic Univ IMSIU, Coll Med, Family Med Dept, Riyadh, Saudi Arabia.
   [AlOtaibi, Azzam D.] Al Imam Muhammad Ibn Saud Islamic Univ IMSIU, Coll Med, Dept Med, Riyadh, Saudi Arabia.
   [Alharbi, Khalid Turki] Prince Sultan Mil Med City, Pharm Serv, Riyadh, Saudi Arabia.
   [Alodayni, Muhannad Abdulwahed] Imam Muhammad Ibn Saud Islamic Univ, Coll Med, Riyadh, Saudi Arabia.
   [Al-Shammari, Sulaiman A.] King Saud Univ, Coll Med, Dept Family & Community Med, Riyadh, Saudi Arabia.
   [Khoja, Tawfik A.] Hlth Ministers Council Cooperat Council States, Riyadh, Saudi Arabia.
C3 King Saud University; Imam Mohammad Ibn Saud Islamic University (IMSIU);
   Imam Mohammad Ibn Saud Islamic University (IMSIU); Imam Mohammad Ibn
   Saud Islamic University (IMSIU); Prince Sultan Military Medical City;
   Imam Mohammad Ibn Saud Islamic University (IMSIU); King Saud University
RP Aljawadi, MH (corresponding author), King Saud Univ, Coll Pharm, Dept Clin Pharm, Riyadh, Saudi Arabia.
EM maljawadi@ksu.edu.sa
RI Khoja, Abdullah/AAD-8780-2020; Arafah, Azher/ABC-7803-2020; Aljawadi,
   Mohammad/R-7589-2017; Almuqbil, Mansour/ABD-3433-2020; Alshammari,
   Sulaiman/IST-6774-2023
OI Alotaibi, Azzam/0000-0002-8537-2748; Alshammari,
   Sulaiman/0000-0001-9596-5590
FU Deanship of Scientific Research at King Saud University [RG-1441-476]
FX The authors extend their appreciation to the Deanship of Scientific
   Research at King Saud University for funding this work through research
   group no. RG-1441-476.
CR AALEN O, 1978, ANN STAT, V6, P701, DOI 10.1214/aos/1176344247
   Abuelgasim KA, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2150-8
   Al Bedah AMN, 2016, J ALTERN COMPLEM MED, V22, P768, DOI 10.1089/acm.2016.0193
   Al-Eidi S, 2016, J INTEGR MED-JIM, V14, P187, DOI 10.1016/S2095-4964(16)60244-3
   Al-Faris EA, 2008, ANN SAUDI MED, V28, P4
   Al-Ghamdi S, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1714-3
   Al-Ramahi R, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0764-7
   Al-Zahim AA, 2013, SAUDI J GASTROENTERO, V19, P75, DOI 10.4103/1319-3767.108477
   AlBedah A, 2015, J ALTERN COMPLEM MED, V21, P504, DOI 10.1089/acm.2015.0065
   AlBedah AM, 2015, J CUTAN MED SURG, V19, P527, DOI 10.1177/1203475415607170
   AlBedah Abdullah M, 2015, Asian Pac J Cancer Prev, V16, P6799, DOI 10.7314/apjcp.2015.16.15.6799
   AlBedah AM, 2013, J ALTERN COMPLEM MED, V19, P918, DOI 10.1089/acm.2013.0162
   AlBedah AMN, 2013, ANN SAUDI MED, V33, P282, DOI 10.5144/0256-4947.2013.282
   AlGhamdi KM, 2015, J CUTAN MED SURG, V19, P570, DOI 10.1177/1203475415584867
   Anderegg MD, 2016, HYPERTENSION, V68, P1314, DOI 10.1161/HYPERTENSIONAHA.116.08043
   Ariff Kamil M, 2006, Aust J Rural Health, V14, P2, DOI 10.1111/j.1440-1584.2006.00747.x
   Armishaw J, 1999, ARCH DIS CHILD, V81, P133, DOI 10.1136/adc.81.2.133
   Astin JA, 1998, JAMA-J AM MED ASSOC, V279, P1548, DOI 10.1001/jama.279.19.1548
   Astin JA, 2000, J GERONTOL A-BIOL, V55, pM4
   Awortwe C, 2018, BRIT J CLIN PHARMACO, V84, P679, DOI 10.1111/bcp.13490
   Ayele AA, 2017, COMPLEMENT THER MED, V35, P115, DOI 10.1016/j.ctim.2017.10.006
   Barnes Patricia M, 2004, Adv Data, P1
   Barnes Patricia M, 2008, Natl Health Stat Report, P1
   Beedie C, 2018, BRIT J SPORT MED, V52, P817, DOI 10.1136/bjsports-2017-097747
   Chang CM, 2019, J ETHNOPHARMACOL, V236, P70, DOI 10.1016/j.jep.2019.02.042
   Chang EY, 2006, AM J SURG, V192, P471, DOI 10.1016/j.amjsurg.2006.05.013
   Cherniack E Paul, 2008, Complement Ther Clin Pract, V14, P116, DOI 10.1016/j.ctcp.2007.11.002
   Clairet AL, 2019, MED ONCOL, V36, DOI 10.1007/s12032-019-1267-z
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   Cordier W, 2012, PHARM BIOL, V50, P443, DOI 10.3109/13880209.2011.611145
   del Mundo WFB, 2002, FAM MED, V34, P206
   EISENBERG DM, 1993, NEW ENGL J MED, V328, P246, DOI 10.1056/NEJM199301283280406
   Elolemy Ahmed Tawfik, 2012, Oman Med J, V27, P20, DOI 10.5001/omj.2012.04
   Ernst E, 2000, B WORLD HEALTH ORGAN, V78, P252
   FISHER P, 1994, BRIT MED J, V309, P107, DOI 10.1136/bmj.309.6947.107
   Foster DF, 2000, J AM GERIATR SOC, V48, P1560, DOI 10.1111/j.1532-5415.2000.tb03864.x
   Gronnesby J K, 1996, Lifetime Data Anal, V2, P315, DOI 10.1007/BF00127305
   Hafner-Blumenstiel Verena, 2011, Ther Umsch, V68, P54, DOI 10.1024/0040-5930/a000120
   He D, 1997, PREV MED, V26, P208, DOI 10.1006/pmed.1996.0125
   Huiart L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0081677
   Hussain MS, 2011, AFR J TRADIT COMPLEM, V8, P152, DOI 10.4314/ajtcam.v8i5S.8
   Hwang AY, 2017, J FAM PRACTICE, V66, pE1
   Hwang SW, 2008, J THORAC ONCOL, V3, P942, DOI 10.1097/JTO.0b013e3181803f1e
   Innes KE, 2017, J ALZHEIMERS DIS, V56, P899, DOI 10.3233/JAD-160867
   Innes KE, 2016, J ALZHEIMERS DIS, V52, P1277, DOI 10.3233/JAD-151106
   Innes KE, 2016, COMPLEMENT THER MED, V26, P98, DOI 10.1016/j.ctim.2016.03.002
   Izzo AA, 2009, DRUGS, V69, P1777, DOI 10.2165/11317010-000000000-00000
   Jan MM, 2009, SAUDI MED J, V30, P682
   Javed F, 2008, J LARYNGOL OTOL, V122, P116, DOI 10.1017/S0022215107000011
   Jazieh AR, 2012, J ALTERN COMPLEM MED, V18, P1045, DOI 10.1089/acm.2011.0266
   Johnson SB, 2018, JAMA ONCOL, V4, P1375, DOI 10.1001/jamaoncol.2018.2487
   Johnson SB, 2018, JNCI-J NATL CANCER I, V110, DOI 10.1093/jnci/djx145
   Abad MJ, 2010, CURR DRUG METAB, V11, P171
   Kamel FO, 2017, COMPLEMENT THER CLIN, V29, P207, DOI 10.1016/j.ctcp.2017.10.007
   Kessler RC, 2001, ANN INTERN MED, V135, P262, DOI 10.7326/0003-4819-135-4-200108210-00011
   Khoja AT, 2017, SAUDI PHARM J
   Kulchaitanaroaj P, 2017, J HYPERTENS, V35, P178, DOI 10.1097/HJH.0000000000001126
   Landin J, 2008, INT J GERIATR PSYCH, V23, P1163, DOI 10.1002/gps.2046
   Liang Ni-Cheng, 2017, Am J Respir Crit Care Med, V195, pP21, DOI [10.1164/rccm.19511p21, 10.1164/rccm.19511P21]
   Lin HW, 2018, J FORMOS MED ASSOC, V117, P235, DOI 10.1016/j.jfma.2017.04.017
   Linetzky B, 2017, J DIABETES, V9, P596, DOI 10.1111/1753-0407.12443
   Linus-Lojikip S, 2019, COMPLEMENT THER CLIN, V37, P73, DOI 10.1016/j.ctcp.2019.09.001
   Mariampillai JE, 2017, BLOOD PRESSURE, V26, P133, DOI 10.1080/08037051.2016.1277129
   Mbada CE, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0695-3
   Meurk C, 2013, HEALTH PLACE, V20, P75, DOI 10.1016/j.healthplace.2012.12.005
   Mohammad Y, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0623-6
   Mohieldin A, 2017, J CANCER EDUC, V32, P314, DOI 10.1007/s13187-015-0973-2
   Moran JM, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1629-z
   Neiberg RH, 2011, J ALTERN COMPLEM MED, V17, P363, DOI 10.1089/acm.2009.0157
   NELSON W, 1972, TECHNOMETRICS, V14, P945, DOI 10.2307/1267144
   Nguyen D, 2014, RURAL REMOTE HEALTH, V14
   Persons AAoR, 2007, COMPL ALT MED WHAT P
   Posadzki P, 2016, COMPLEMENT THER MED, V29, P141, DOI 10.1016/j.ctim.2016.09.019
   Public IoMUCotUoCaAMbtA, 2005, COMPL ALT MED US
   Rakovitch E, 2005, BREAST CANCER RES TR, V90, P139, DOI 10.1007/s10549-004-3779-1
   Ramos FL, 2014, INT J CHRONIC OBSTR, V9, P139, DOI 10.2147/COPD.S38938
   Roumeliotis GA, 2017, PLAST SURG-CHIR PLAS, V25, P275, DOI 10.1177/2292550317716126
   Saydah SH, 2006, J ALTERN COMPLEM MED, V12, P805, DOI 10.1089/acm.2006.12.805
   Schnabel K, 2014, BMC GERIATR, V14, DOI 10.1186/1471-2318-14-38
   Shumer G, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-360
   Singh Vimal, 2004, BMC Complement Altern Med, V4, P3, DOI 10.1186/1472-6882-4-3
   Smith SM, 2016, J AM SOC HYPERTENS, V10, P307, DOI 10.1016/j.jash.2016.01.010
   Sood A, 2006, NICOTINE TOB RES, V8, P767, DOI 10.1080/14622200601004109
   Statistics GAo, 2018, POP EST
   Sturman MT, 2008, NEUROLOGY, V70, P360, DOI 10.1212/01.wnl.0000285081.04409.bb
   Sullivan A, 2015, INTEGR CANCER THER, V14, P350, DOI 10.1177/1534735415580679
   Thomas K, 2004, J PUBLIC HEALTH, V26, P152, DOI 10.1093/pubmed/fdh139
   Tindle HA, 2005, ALTERN THER HEALTH M, V11, P42
   Turkmenoglu FP, 2016, COMPLEMENT THER CLIN, V23, P46, DOI 10.1016/j.ctcp.2016.03.004
   Waite NR, 1998, BRIT J GEN PRACT, V48, P1487
   Wang SH, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1337-0
   Weeger S, 2017, DISABIL REHABIL, V39, P468, DOI 10.3109/09638288.2016.1146360
   Williams AM, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-47
   Xue CCL, 2007, J ALTERN COMPLEM MED, V13, P643, DOI 10.1089/acm.2006.6355
   Zeller T, 2013, J CANCER RES CLIN, V139, P357, DOI 10.1007/s00432-012-1336-6
   Zeng LF, 2015, PHYTOTHER RES, V29, P1843, DOI 10.1002/ptr.5481
NR 96
TC 17
Z9 25
U1 0
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD AUG 7
PY 2020
VL 2020
AR 4357194
DI 10.1155/2020/4357194
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA NE8SE
UT WOS:000562874700003
PM 32831865
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Tan, MY
   Mo, CY
   Zhao, Q
AF Tan, Mo-Yao
   Mo, Chao-Yue
   Zhao, Qian
TI Research hotspots and trends on acupuncture therapy on vomiting from
   1990 to 2022: A bibliometric analysis
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Acupuncture; Vomiting; Hotspots and trends; Bibliometric analysis
ID CHEMOTHERAPY-INDUCED NAUSEA; POSTOPERATIVE NAUSEA; POINT STIMULATION;
   CANCER; PAIN; MANAGEMENT
AB Objectives: Acupuncture treatment (AT) is commonly utilized for vomiting; however, limited bibliometric ana-lyses exist in this area. Employing a bibliometric approach, we conducted a comprehensive review spanning three decades to assess the research landscape, advancements, and emerging trends in AT for vomiting.Methods: We collected the related literature data from the Web of Science Core Collection (WOSCC) from 1990 to 2022. VOSviewer and R studio were used to perform the bibliometric analysis of AT on vomiting. The status of authors, countries, affiliations, annual publications, keywords, and journals were analyzed accordingly. Results: The earliest relevant paper was published in 1990. Streitberger, K was the most productive author (7 records) and had significant influence (225 reference times, H-Index = 7). The United States had the highest publication count (224 records) and received the most recognition (9719 reference times, H-Index = 52). MEDICINE had the highest number of outputs (34 records), while ANESTHESIA AND ANALGESIA was the most cited journal (1045 reference times). The institution with the most works was Chengdu University of Traditional Chinese Medicine (CDUTCM) (13 records), and the University of California, Los Angeles received the most ci-tations (1252 reference times). Recent and future research hotspots included AT for postoperative vomiting and post-chemotherapy vomiting. Systematic reviews and meta-analyses were the predominant study types.Conclusions: The current status and development prospects of AT for vomiting are shown in this study. In addition, this article provides valuable ideas and potential directions for future research activities.
C1 [Tan, Mo-Yao; Zhao, Qian] Chengdu First Peoples Hosp, Chengdu, Sichuan, Peoples R China.
   [Mo, Chao-Yue] Chengdu Univ Tradit Chinese Med, Coll Life & Sci, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Zhao, Q (corresponding author), Chengdu First Peoples Hosp, Chengdu, Sichuan, Peoples R China.
EM zhaoqian6628@163.com
CR [Anonymous], 1997, NIH Consens Statement, V15, P1
   Aria M, 2017, J INFORMETR, V11, P959, DOI 10.1016/j.joi.2017.08.007
   Asmussen S, 2017, J NEUROSURG ANESTH, V29, P219, DOI 10.1097/ANA.0000000000000290
   Bartneck C, 2011, SCIENTOMETRICS, V87, P85, DOI 10.1007/s11192-010-0306-5
   Becker Daniel E, 2010, Anesth Prog, V57, P150, DOI 10.2344/0003-3006-57.4.150
   Bhandari S, 2017, DIGEST DIS SCI, V62, P2035, DOI 10.1007/s10620-016-4432-7
   Boyack KW, 2010, J AM SOC INF SCI TEC, V61, P2389, DOI 10.1002/asi.21419
   Dou BM, 2020, J CLIN ACUPUNCT MOXI, V36, P72, DOI [10.3969/j.issn.1005-0779.2020.10.019, DOI 10.3969/J.ISSN.1005-0779.2020.10.019]
   DUNDEE JW, 1989, LANCET, V1, P1016
   Enblom A, 2017, COMPLEMENT THER MED, V34, P141, DOI 10.1016/j.ctim.2017.08.003
   Enblom A, 2017, ACUPUNCT MED, V35, P251, DOI 10.1136/acupmed-2015-011007
   Enblom A, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/5806351
   Ezzo J, 2005, J CLIN ONCOL, V23, P7188, DOI 10.1200/JCO.2005.06.028
   Ezzo J, 2006, J ALTERN COMPLEM MED, V12, P489, DOI 10.1089/acm.2006.12.489
   Fan SJ, 2018, CLIN J CHIN MED, V10, P122
   Fernández-Ortega P, 2012, SUPPORT CARE CANCER, V20, P3141, DOI 10.1007/s00520-012-1448-1
   Gan TJ, 2020, ANESTH ANALG, V131, P411, DOI 10.1213/ANE.0000000000004833
   Gang Wei-Juan, 2023, Zhongguo Zhen Jiu, V43, P3, DOI 10.13703/j.0255-2930.20221205-0001
   Gao W, 2021, SURGERY, V170, P1618, DOI 10.1016/j.surg.2021.08.007
   Hao TY, 2018, SOFT COMPUT, V22, P7875, DOI 10.1007/s00500-018-3511-4
   Jerson B, 2019, CURR OPIN PEDIATR, V31, P630, DOI 10.1097/MOP.0000000000000800
   Kim KH, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-013457
   Kim SY, 2015, ACUPUNCT MED, V33, P148, DOI 10.1136/acupmed-2014-010641
   Kotani N, 2001, ANESTHESIOLOGY, V95, P349, DOI 10.1097/00000542-200108000-00015
   Kovac AL, 2021, PEDIATR DRUGS, V23, P11, DOI 10.1007/s40272-020-00424-0
   Kovacic K, 2021, HEADACHE, V61, P231, DOI 10.1111/head.14073
   Lariviere Vincent, 2013, Nature, V504, P211
   Lee A, 1999, ANESTH ANALG, V88, P1362, DOI 10.1097/00000539-199906000-00031
   Lee A, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003281.pub4
   [李旷宇 Li Kuangyu], 2020, [中草药, Chinese Traditional and Herbal Drugs], V51, P2046
   Li S, 2019, EUR J INTEGR MED, V30, DOI 10.1016/j.eujim.2019.100951
   Lin WL, 2022, HUNAN J TRADIT CHIN, V38, P111, DOI [10.16808/j.cnki.issn1003-7705.2022.01.033, DOI 10.16808/J.CNKI.ISSN1003-7705.2022.01.033]
   Lindley C, 1999, CANCER PRACT, V7, P59, DOI 10.1046/j.1523-5394.1999.07205.x
   Liodden I, 2011, ACUPUNCT MED, V29, P9, DOI 10.1136/aim.2010.002915
   Liu MY, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000024588
   Lu Jian-Qin, 2013, Zhen Ci Yan Jiu, V38, P245
   MALAGELADA JR, 1984, ANN INTERN MED, V101, P211, DOI 10.7326/0003-4819-101-2-211
   Norheim A J, 2001, Tidsskr Nor Laegeforen, V121, P2712
   Norheim AJ, 2011, ACUPUNCT MED, V29, P3, DOI 10.1136/aim.2011.003988
   Parkman HP, 2011, GASTROENTEROLOGY, V141, P486, DOI 10.1053/j.gastro.2011.04.045
   Parkman HP, 2011, GASTROENTEROLOGY, V140, P101, DOI 10.1053/j.gastro.2010.10.015
   Rithirangsriroj K, 2015, GYNECOL ONCOL, V136, P82, DOI 10.1016/j.ygyno.2014.10.025
   Rosen T, 2003, OBSTET GYNECOL, V102, P129, DOI 10.1016/S0029-7844(03)00375-2
   Shi YZ, 2016, WORLD CHIN MED, V11, P209, DOI [10.3969/j.issn.1673-7202.2016.02.006, DOI 10.3969/J.ISSN.1673-7202.2016.02.006]
   Stoicea N, 2015, FRONT MED, V2, DOI 10.3389/fmed.2015.00087
   Streitberger K, 2006, AUTON NEUROSCI-BASIC, V129, P107, DOI 10.1016/j.autneu.2006.07.015
   Streitberger K, 2011, EUR J ANAESTH, V28, P396, DOI 10.1097/EJA.0b013e3283412529
   Tan MY, 2023, FRONT PUBLIC HEALTH, V11, DOI 10.3389/fpubh.2023.1108756
   van Eck NJ, 2010, SCIENTOMETRICS, V84, P523, DOI 10.1007/s11192-009-0146-3
   Van Eck NJ., 2014, MEASURING SCHOLARLY, P285, DOI [DOI 10.1007/978-3-319-10377-8_13, 10.1007/978-3-319-10377-8_13]
   Vasigh A, 2018, ANAESTH PAIN INTENSI, V22, P499
   WATCHA MF, 1992, ANESTHESIOLOGY, V77, P162, DOI 10.1097/00000542-199207000-00023
   Xu Mj, 2023, J CLIN ACUPUNCT MOXI, V39, P16, DOI [10.19917/j.cnki.1005-0779.023090, DOI 10.19917/J.CNKI.1005-0779.023090]
   Yan YQ, 2023, CANCER MED-US, V12, P12504, DOI 10.1002/cam4.5962
   Yao YS, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/324360
   Yin ZH, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/7509481
   Yu Zengfang, 2017, Shanxi J Trad Chinese Med, V33, P49
   Zhu J, 2022, ACUPUNCT MED, V40, P415, DOI 10.1177/09645284221076517
NR 58
TC 6
Z9 7
U1 1
U2 49
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD SEP
PY 2023
VL 76
AR 102962
DI 10.1016/j.ctim.2023.102962
EA JUL 2023
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA N5YT0
UT WOS:001037771100001
PM 37406969
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Al-Ajlouni, YA
   Al Ta'ani, O
   Zweig, SA
   Bak, M
   Tanashat, M
   Gabr, A
   Khamis, Z
   Al-Bitar, F
   Islam, M
AF Al-Ajlouni, Yazan A.
   Al Ta'ani, Omar
   Zweig, Sophia A.
   Bak, Magdalena
   Tanashat, Mohammad
   Gabr, Ahmed
   Khamis, Zaid
   Al-Bitar, Farah
   Islam, Mohammad
TI Assessing the Therapeutic Role of Rehabilitation Programs in
   Chemotherapy-Induced Peripheral Neuropathy (CIPN)-A Scoping Review
SO HEALTHCARE
LA English
DT Review
DE chemotherapy-induced peripheral neuropathy; rehabilitation programs;
   pain management; neuropathic symptoms; scoping review
ID QUALITY-OF-LIFE; COLORECTAL-CANCER; CONTROLLED-TRIAL; BREAST; STRENGTH;
   YOGA; PREVENTION; SURVIVORS; PAIN
AB Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating side effect of cancer treatment. Characterized by symptoms like pain, numbness, and muscle weakness, CIPN significantly impacts patients' quality of life. Current management strategies vary, with limited consensus on effective treatments. This scoping review aims to explore comprehensive rehabilitation interventions for CIPN, focusing on enhancing patient well-being and functional abilities. Methods: A scoping review, guided by Arksey and O'Malley's framework and Levac et al.'s refinements, was conducted to assess rehabilitation programs for CIPN. Searches across six databases were performed, with inclusion and exclusion criteria focusing on studies with physical rehabilitation interventions. Data were charted, detailing interventions, demographics, and outcomes. Results were synthesized descriptively and presented narratively with tables. Results: The review included 24 studies covering diverse cancer types and treatments, involving a total of 1167 participants. Various interventions for CIPN were assessed, and results were thematically categorized according to exercise category. Physical modalities like ultrasound and exercise showed promise in symptom relief for colorectal and breast cancer patients. No distinct advantage was found in the timing of exercise interventions. Complementary therapies such as acupuncture and yoga demonstrated effectiveness in managing CIPN symptoms. Conclusions: This review highlights the effectiveness of diverse physical and complementary interventions in managing CIPN, advocating for their integration into standard protocols. It emphasizes the need for holistic, patient-centered approaches that combine exercises, physical therapy, and complementary therapies to improve patient outcomes. These findings set a direction for future research and clinical practices focused on comprehensive and personalized CIPN management strategies.
C1 [Al-Ajlouni, Yazan A.; Gabr, Ahmed] New York Med Coll, Sch Med, Valhalla, NY 10595 USA.
   [Al-Ajlouni, Yazan A.; Islam, Mohammad] Metropolitan Hosp, Dept Phys Med & Rehabil, New York, NY 10029 USA.
   [Al-Ajlouni, Yazan A.; Khamis, Zaid] Staten Isl Univ Hosp, Dept Med, Staten Isl, NY 10305 USA.
   [Al Ta'ani, Omar] Alleghany Hlth Network, Pittsburgh, PA USA.
   [Zweig, Sophia A.] SUNY Downstate Coll Med, Sch Med, Brooklyn, NY 11203 USA.
   [Bak, Magdalena] New York Univ Abu Dhabi NYUAD, Sch Sci, POB 129188, Abu Dhabi, U Arab Emirates.
   [Tanashat, Mohammad] Yarmouk Univ, Fac Med, Irbid 21163, Jordan.
   [Al-Bitar, Farah] Western Michigan Univ, Homer Stryker MD Sch Med, Kalamazoo, MI 49007 USA.
C3 New York Medical College; Metropolitan Hospital Center; Northwell
   Health; State University of New York (SUNY) System; SUNY Downstate
   Health Sciences University; Yarmouk University; Western Michigan
   University
RP Al-Ajlouni, YA (corresponding author), New York Med Coll, Sch Med, Valhalla, NY 10595 USA.; Al-Ajlouni, YA (corresponding author), Metropolitan Hosp, Dept Phys Med & Rehabil, New York, NY 10029 USA.; Al-Ajlouni, YA (corresponding author), Staten Isl Univ Hosp, Dept Med, Staten Isl, NY 10305 USA.
EM alajlouni.yazan@gmail.com
RI ; Gabr, Ahmed/ABZ-3954-2022; Al Ta'ani, Omar/LMO-8687-2024
OI Al-Ajlouni, Yazan/0000-0002-1718-4964; Khamis, Zaid/0009-0004-8625-3953;
   
CR Al Onazi MM, 2021, J PAIN SYMPTOM MANAG, V61, P1127, DOI 10.1016/j.jpainsymman.2020.10.028
   Anshu A, 2022, International Journal of Alternative and Complementary Medicine, P17, DOI [10.46797/ijacm.v3i2.341, 10.46797/ijacm.v3i2.341, DOI 10.46797/IJACM.V3I2.341]
   Arksey H., 2005, INT J SOC RES METHOD, V8, P19, DOI [DOI 10.1080/1364557032000119616, 10.1080/1364557032000119616, DOI 10.1080/136.455.7032000119616]
   Ben-Arye E, 2022, CANCER-AM CANCER SOC, V128, P3641, DOI 10.1002/cncr.34422
   Bland KA, 2019, CLIN BREAST CANCER, V19, P411, DOI 10.1016/j.clbc.2019.05.013
   Bös C, 2023, FRONT PSYCHOL, V14, DOI 10.3389/fpsyg.2023.1096848
   Bonakdar Robert, 2019, Glob Adv Health Med, V8, p2164956119855629, DOI [10.1177/2164956119855629, 10.1177/2164956119855629]
   Bower JE, 2012, CANCER-AM CANCER SOC, V118, P3766, DOI 10.1002/cncr.26702
   Boyette-Davis JA, 2018, PAIN MANAG, V8, P363, DOI 10.2217/pmt-2018-0020
   Buckner SL, 2017, SPORTS MED, V47, P193, DOI 10.1007/s40279-016-0580-3
   Cartwright T, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-031848
   Cramer H, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-412
   De Melo MN, 2022, CURR ONCOL REP, V24, P1363, DOI 10.1007/s11912-022-01296-y
   Dhawan S, 2020, CANCER NURS, V43, P269, DOI 10.1097/NCC.0000000000000693
   Dixit S, 2023, LIFE-BASEL, V13, DOI 10.3390/life13020262
   Eckhoff L, 2015, EUR J CANCER, V51, P292, DOI 10.1016/j.ejca.2014.11.024
   Fremion E, 2020, J PEDIATR REHAB MED, V13, P513, DOI 10.3233/PRM-200718
   Galantino ML, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419850627
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Grgic J, 2020, SPORTS MED, V50, P1983, DOI 10.1007/s40279-020-01331-7
   Grisold W, 2012, NEURO-ONCOLOGY, V14, P45, DOI 10.1093/neuonc/nos203
   Guizelini PC, 2018, EXP GERONTOL, V102, P51, DOI 10.1016/j.exger.2017.11.020
   Haffer H, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-92788-7
   Hammond EA, 2020, NEUROREHAB NEURAL RE, V34, P235, DOI 10.1177/1545968319899918
   Huang YJ, 2024, FRONT NEUROL, V14, DOI 10.3389/fneur.2023.1252259
   Ikio Y, 2022, SUPPORT CARE CANCER, V30, P4981, DOI 10.1007/s00520-022-06846-5
   Iravani S, 2020, PAIN RES MANAG, V2020, DOI 10.1155/2020/2504674
   Izgu N, 2019, EUR J ONCOL NURS, V40, P36, DOI 10.1016/j.ejon.2019.03.002
   Kneis S, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-5522-7
   Knoerl R, 2022, J CANCER SURVIV, V16, P882, DOI 10.1007/s11764-021-01081-z
   Knoerl R, 2018, J PAIN, V19, P382, DOI 10.1016/j.jpain.2017.11.009
   Levac D, 2010, IMPLEMENT SCI, V5, DOI 10.1186/1748-5908-5-69
   Li Y, 2021, CANCERS, V13, DOI 10.3390/cancers13040766
   Loprinzi C, 2020, SUPPORT CARE CANCER, V28, P1183, DOI 10.1007/s00520-019-04881-3
   Maestas NA, 2021, J DISABIL POLICY STU, V32, P13, DOI 10.1177/1044207320933211
   Quintao NLM, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00907
   Osmani K, 2012, J NEUROL, V259, P1936, DOI 10.1007/s00415-012-6442-5
   Prinsloo S, 2017, CANCER-AM CANCER SOC, V123, P1989, DOI 10.1002/cncr.30649
   Quasthoff S, 2002, J NEUROL, V249, P9, DOI 10.1007/PL00007853
   Rick O, 2017, BIOELECTROMAGNETICS, V38, P85, DOI 10.1002/bem.22005
   Ross A, 2013, COMPLEMENT THER MED, V21, P313, DOI 10.1016/j.ctim.2013.04.001
   Rosson Gedge D, 2006, Clin Podiatr Med Surg, V23, P637
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Shibata Yosuke, 2020, J Phys Ther Sci, V32, P428, DOI [10.1589/jpts.32.428, 10.1589/jpts.32.428]
   Simão Delma Aurélia da Silva, 2015, Rev. dor, V16, P215, DOI [10.5935/1806-0013.20150043, 10.5935/1806-0013.20150043]
   Smith EML, 2013, JAMA-J AM MED ASSOC, V309, P1359, DOI 10.1001/jama.2013.2813
   Song SY, 2020, INTEGR CANCER THER, V19, DOI 10.1177/1534735420925519
   Streckmann F, 2014, ANN ONCOL, V25, P493, DOI 10.1093/annonc/mdt568
   Streckmann F, 2019, SUPPORT CARE CANCER, V27, P2471, DOI 10.1007/s00520-018-4531-4
   Tamburin S, 2022, CRIT REV ONCOL HEMAT, V171, DOI 10.1016/j.critrevonc.2021.103575
   Tanay MAL, 2023, J CANCER SURVIV, V17, P254, DOI 10.1007/s11764-021-00997-w
   Tricco AC, 2018, ANN INTERN MED, V169, P467, DOI 10.7326/M18-0850
   Villemure C, 2015, FRONT HUM NEUROSCI, V9, DOI 10.3389/fnhum.2015.00281
   Vollmers PL, 2018, J CANCER RES CLIN, V144, P1785, DOI 10.1007/s00432-018-2686-5
   Waibel S, 2021, ANN CLIN TRANSL NEUR, V8, P1680, DOI 10.1002/acn3.51426
   Windebank AJ, 2008, J PERIPHER NERV SYST, V13, P27, DOI 10.1111/j.1529-8027.2008.00156.x
   Zhang X, 2017, BIOMED REP, V6, P267, DOI 10.3892/br.2017.851
   Zhao HT, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192315491
   Zhi WI, 2021, CANCER RES, V81
   Zimmer P, 2018, SUPPORT CARE CANCER, V26, P615, DOI 10.1007/s00520-017-3875-5
NR 60
TC 0
Z9 0
U1 5
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD JUN 26
PY 2025
VL 13
IS 13
AR 1526
DI 10.3390/healthcare13131526
PG 21
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 4TL0Z
UT WOS:001526255100001
PM 40648551
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Chen, J
   Liu, QF
   Xiong, J
   Lu, LB
   Zhu, SY
   Zhong, ZY
   Tang, GH
   Zhou, XC
   Guo, H
   Chen, ZJ
AF Chen, Jun
   Liu, Qifang
   Xiong, Jun
   Lu, Lunbin
   Zhu, Siyuan
   Zhong, Zhiying
   Tang, Genhua
   Zhou, Xingchen
   Guo, Han
   Chen, Zhijun
TI Effect of fire needle for ganglion cysts A protocol of systematic review
   and meta-analysis of randomized controlled trials
SO MEDICINE
LA English
DT Article
DE acupuncture; fire needle; ganglion cysts; protocol; systematic review;
   tendon sheath
ID HAND
AB Background: Ganglion cysts (GCs) are tumor-like lesions that often occur in the soft tissues, which are mostly caused by the degeneration of mucin produced by the joint capsule and tendon sheath on the carpal dorsal joints of extremities. GCs may appear asymptomatic as benign tumors, but some patients also seek treatment because of the pain caused by these fluid-filled cysts. As a kind of complementary and alternative therapy, there have been some studies published in China which have proved that the fire needle has a better therapeutic effect on ganglion cyst. The purpose of this systematic review is to evaluate the efficacy of fire needle in the treatment of GCs. Methods: PubMed, EMBASE, the Cochrane Library, Chinese National Knowledge Infrastructure, Chinese VIP Information, Wanfang Database, and Chinese Biomedical Literature Database were searched by 2 reviewers from the inception until August 2020. The original study that randomised control trials of fire needle for GCs will be selected and is not limited by country or language. In addition, researches in progress, the reference lists and the citation lists of identified publications will be retrieved similarly. Study selection, data extraction, and assessment of the quality will be performed independently by 2 reviewers who have been trained prior to data extraction. A meta-analysis will be conduct if the quantity and quality of the original studies included are satisfactory; otherwise, a descriptive analysis will be conducted. Review Manager V5.4: (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) software will be using for data synthesis and assessment the risk of bias according by Cochrane Handbook. Result: This study will provide a comprehensive review of current evidence for the treatment of fire needle on GCs. Conclusion: The conclusion of this study will provide a judging basis that whether the treatment of GCs with fire needle is effective. INPLASY registration number: INPLASY202080032
C1 [Chen, Jun; Lu, Lunbin; Zhu, Siyuan; Zhong, Zhiying; Tang, Genhua] Jiangxi Univ Tradit Chinese Med, Nanchang, Jiangxi, Peoples R China.
   [Liu, Qifang] Jiangxi Univ Tradit Chinese Med, Nanchang Hosp 1, Nanchang, Jiangxi, Peoples R China.
   [Xiong, Jun; Zhou, Xingchen; Guo, Han; Chen, Zhijun] Jiangxi Univ Tradit Chinese Med, Affiliated Hosp, 445 Bayi Ave, Nanchang 330009, Jiangxi, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine; Jiangxi University
   of Traditional Chinese Medicine; Jiangxi University of Traditional
   Chinese Medicine; Affiliated Hospital of Jiangxi University of
   Traditional Chinese Medicine
RP Xiong, J (corresponding author), Jiangxi Univ Tradit Chinese Med, Affiliated Hosp, 445 Bayi Ave, Nanchang 330009, Jiangxi, Peoples R China.
EM xiongjun196071@163.com
RI ; Yang, Jun/GSE-2352-2022; Chen, Jun/HPG-3928-2023
OI Zhou, Xing-chen/0000-0002-5700-2942; 
FU Project of Jiangxi University of Traditional Chinese Medicine 1050 youth
   talent project [:5141900101]; National Natural Science Foundation
   [:81573835]; distinguished Young Talents Plan of Jiangxi Province
   [20171BCB23093]; Natural Science Youth Foundation Key Projects of
   Jiangxi Province [20192ACB21007]
FX This work was supported by Project of Jiangxi University of Traditional
   Chinese Medicine 1050 youth talent project (Grant number:5141900101),
   National Natural Science Foundation (Grant number:81573835),
   distinguished Young Talents Plan of Jiangxi Province (Grant No.
   20171BCB23093), and Natural Science Youth Foundation Key Projects of
   Jiangxi Province (Grant No. 20192ACB21007).
CR [Anonymous], 2009, BMJ-BRIT MED J, V6, pe1000097, DOI [DOI 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, DOI 10.1371/JOURNAL.PMED.1000097]
   Atkins D, 2004, BMJ-BRIT MED J, V328, P1490
   Chen PY, 2011, J MED IMAGING, V21, P1734
   DU X., 2018, J CLIN ACUPUNCT MOXI, V34, P1
   Ebrahim S, 2013, J CLIN EPIDEMIOL, V66, P1014, DOI 10.1016/j.jclinepi.2013.03.014
   Giard MC, 2015, RHEUMATOL INT, V35, P597, DOI 10.1007/s00296-014-3120-1
   Higgins J, 2019, Cochrane Handbook for Systematic Reviews of Interventions, DOI DOI 10.1002/9781119536604.CH17
   Higgins JP, 2011, ASSESSING RISK BIAS, P187
   Li SL, 2019, ANN PLAS SURG, V82, P577, DOI 10.1097/SAP.0000000000001584
   Liang Teresa, 2013, HSS J, V9, P270, DOI 10.1007/s11420-013-9345-9
   Luo Y, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/8797056
   Nahra ME, 2011, OPERATIVE TECHNIQUES, V3, P3010
   Soren A, 1966, Clin Orthop Relat Res, V48, P173
   Tang ZH, 2017, SINGAP MED J, V58, P714, DOI 10.11622/smedj.2016147
   Wang LP, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/3513179
   Xueyong Z., 1990, NEW ROUTINE DIAGNOSI
   ZUBOWICZ VN, 1987, J HAND SURG-AM, V12A, P618, DOI 10.1016/S0363-5023(87)80221-6
NR 17
TC 2
Z9 2
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 9
PY 2020
VL 99
IS 41
AR e22602
DI 10.1097/MD.0000000000022602
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OC6DZ
UT WOS:000579245800061
PM 33031314
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Stomski, NJ
   Petterson, A
   Kristjanson, L
   Lobb, EA
   Phillips, M
   Williamsa, A
   Morrison, P
   Joske, D
AF Stomski, N. J.
   Petterson, A.
   Kristjanson, L.
   Lobb, E. A.
   Phillips, M.
   Williamsa, A.
   Morrison, P.
   Joske, D.
TI The effect of self-selected complementary therapies on cancer patients'
   quality of life and symptom distress: A prospective cohort study in an
   integrative oncology setting
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Cancer; Complementary therapies; Quality of life; Distress; Prospective
   study
ID ALTERNATIVE MEDICINE; CARE; PAIN; COMMUNICATION; ACUPUNCTURE
AB Objective: To examine the effectiveness of a multifaceted complementary therapies intervention, delivered in a systematic manner within an Australian public hospital setting, on quality of life and symptom distress outcomes for cancer patients.
   Methods: Adults receiving treatment for any form of cancer were eligible to participate in this study. Self-referred participants were offered a course of six complementary therapy sessions. Measures were administered at baseline, and at the third and sixth visit. The primary outcomes were quality of life and symptom distress. Linear mixed models were used to assess change in the primary outcomes.
   Results: In total, 1376 cancer patients participated in this study. The linear mixed models demonstrated that there were significant improvements in quality of life and significant reductions in symptom distress over six sessions. Body-based therapies demonstrated significantly superior improvement in quality of life over counselling, but no other differences between therapies were identified. Reduced symptom distress was not significantly associated with any particular type of therapy.
   Conclusion: A self-selected complementary therapies intervention, provided in an Australian public hospital by accredited therapists, for cancer patients significantly improved quality of life and reduced symptom distress. The effect of this intervention on quality of life has particular salience, since cancer impacts on many areas of people's lives and impairs quality of life.
C1 [Stomski, N. J.; Williamsa, A.; Morrison, P.] Murdoch Univ, Sch Hlth Profess, 90 South St, Murdoch, WA 6150, Australia.
   [Petterson, A.; Joske, D.] Sir Charles Gairdner Hosp, SolarisCare Fdn, Nedlands, WA, Australia.
   [Kristjanson, L.] Swinburne Univ Technol, Chancellery, Hawthorn, Vic, Australia.
   [Lobb, E. A.] Univ Notre Dame Sydney, Sch Med, Darlinghurst, NSW, Australia.
   [Lobb, E. A.] Calvary Hlth Care Sydney, Kogarah, NSW, Australia.
   [Lobb, E. A.] Cunningham Ctr Palliat Care, Darlinghurst, NSW, Australia.
   [Phillips, M.] Harry Perkins Inst Med Res, Nedlands, WA, Australia.
   [Phillips, M.] Univ Western Australia, Ctr Med Res, Crawley, WA, Australia.
   [Phillips, M.] Royal Perth Hosp, Perth, WA, Australia.
   [Williamsa, A.] Sir Charles Gairdner Hosp, Ctr Nursing Res, Nedlands, WA, Australia.
   [Joske, D.] Sir Charles Gairdner Hosp, Dept Haematol, Nedlands, WA, Australia.
   [Joske, D.] Univ Western Australia, Fac Hlth & Med Sci, Crawley, WA, Australia.
C3 Murdoch University; University of Western Australia; Sir Charles
   Gairdner Hospital; Swinburne University of Technology; The University of
   Notre Dame Australia; University of Notre Dame Australia - Sydney;
   University of Notre Dame Australia - Sydney Campus Darlinghurst; Harry
   Perkins Institute of Medical Research; University of Western Australia;
   University of Western Australia; East Metropolitan Health Service; Royal
   Perth Hospital; University of Western Australia; Sir Charles Gairdner
   Hospital; University of Western Australia; Sir Charles Gairdner
   Hospital; University of Western Australia
RP Stomski, NJ (corresponding author), Murdoch Univ, Sch Hlth Profess, 90 South St, Murdoch, WA 6150, Australia.
EM N.Stomski@murdoch.edu.au
RI ; Willia, Anne/L-4808-2013
OI Phillips, Michael/0000-0002-0252-9085; Morrison,
   Paul/0000-0002-3389-8393; Willia, Anne/0000-0003-1564-8574
CR Bardia A, 2006, J CLIN ONCOL, V24, P5457, DOI 10.1200/JCO.2006.08.3725
   Ben-Arye E, 2013, MED ONCOL, V30, DOI 10.1007/s12032-013-0511-1
   Boutron I, 2017, ANN INTERN MED, V167, P40, DOI 10.7326/M17-0046
   Commonwealth of Australia, 2014, OUT POCK COSTS AUSTR
   Deng G, 2013, NAT REV CLIN ONCOL, V10, P656, DOI 10.1038/nrclinonc.2013.125
   Deng Gary E, 2009, J Soc Integr Oncol, V7, P85
   Frenkel M, 2010, INTEGR CANCER THER, V9, P177, DOI 10.1177/1534735410363706
   Horneber M, 2012, INTEGR CANCER THER, V11, P187, DOI 10.1177/1534735411423920
   Huisman ERCM, 2012, BUILD ENVIRON, V58, P70, DOI 10.1016/j.buildenv.2012.06.016
   Keshet Y, 2015, PSYCHO-ONCOLOGY, V24, P169, DOI 10.1002/pon.3621
   Lim E, 2017, ASIA-PAC J CLIN ONCO, V13, P6, DOI 10.1111/ajco.12591
   Linde K, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-75
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Oh Byeongsang, 2010, J Soc Integr Oncol, V8, P56
   Quirino M, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006522
   Richardson MA, 2000, J CLIN ONCOL, V18, P2505, DOI 10.1200/JCO.2000.18.13.2505
   Roberts CS, 2005, J PSYCHOSOC ONCOL, V23, P35, DOI 10.1300/J077v23n04_03
   Saccà L, 2010, INTERN EMERG MED, V5, P201, DOI 10.1007/s11739-010-0355-z
   Singh P, 2015, INDIAN J PALLIAT CAR, V21, P105, DOI 10.4103/0973-1075.150202
   Stomski NJ, 2014, ACUPUNCT MED, V32, P333, DOI 10.1136/acupmed-2013-010477
   Verhoef MJ, 2008, CURR ONCOL, V15, pS88
   Verhoef Marja J, 2005, Integr Cancer Ther, V4, P274, DOI 10.1177/1534735405282361
   Williams AM, 2014, J HOLIST NURS, V32, P250, DOI 10.1177/0898010114526951
NR 23
TC 8
Z9 12
U1 0
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD APR
PY 2018
VL 37
BP 1
EP 5
DI 10.1016/j.ctim.2018.01.006
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GD8RT
UT WOS:000430780500001
PM 29609920
DA 2026-01-16
ER

PT J
AU Campbell, CL
   Campbell, LC
AF Campbell, Cathy L.
   Campbell, Lisa C.
TI A systematic review of cognitive behavioral interventions in advanced
   cancer
SO PATIENT EDUCATION AND COUNSELING
LA English
DT Review
DE Advanced neoplasms; Cognitive-behavioral; Cognitive therapy;
   Psycho-educational interventions; Adults
ID QUALITY-OF-LIFE; PALLIATIVE CARE; PSYCHOLOGICAL INTERVENTIONS; PAIN
   MANAGEMENT; SELF-EFFICACY; DISTRESS; ISSUES; CAREGIVERS; SYMPTOMS;
   SURVIVAL
AB Objective: To systematically review cognitive behavioral interventions for people with advanced cancer.
   Methods: A literature search was conducted using Medline(C), CINAHL(C), and Psych-info(C). Inclusion criteria: studies were included in the review if they met the following criteria: (1) the design was a randomized clinical trial, (2) the study tested a cognitive behavioral therapy, including psycho-educational, alternative and complementary therapies (i.e. acupuncture, relaxation), expressive, support and skill building interventions, (3) participants were adults (18 years of age or older) with advanced cancer and the (4) outcomes were directly related to the patient with advanced cancer.
   Results: 11 studies met the inclusion criteria. Of the studies in the review: treatment effects were not statistically significant in most studies, methods were not consistently described, and samples had limited racial/ethnic diversity.
   Conclusion: The interpretation of the effectiveness of the CBIs was limited by major challenges to the internal validity of the studies included in the review. The lack of data about the efficacy of CBIs to support people with advanced cancer is a gap in the current knowledge base. Practice implications: Given the needs of people living with advanced cancer well-designed studies are needed to test interventions that will improve outcomes for people living with advanced cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Campbell, Cathy L.] Univ Virginia, Sch Nursing, Dept Acute & Specialty Care, Charlottesville, VA 22903 USA.
   [Campbell, Lisa C.] E Carolina Univ, Dept Psychol, Greenville, NC 27858 USA.
C3 University of Virginia; University of North Carolina; East Carolina
   University
RP Campbell, CL (corresponding author), Univ Virginia, Sch Nursing, Dept Acute & Specialty Care, 202 Jeanette Lancaster Way,McLeod Hall, Charlottesville, VA 22903 USA.
EM clc5t@virginia.edu
FU NIH/NCI [5R01CA122704-04, 3R01CA122704-03S1]
FX Development of the manuscript was supported by 5R01CA122704-04 (Dr. Lisa
   Campbell) and 3R01CA122704-03S1 NIH/NCI (Dr. Lisa Campbell and Dr. Cathy
   Campbell).
CR [Anonymous], BMC MED RES METHODOL
   [Anonymous], 2011, Cancer Facts and Figures 2011
   [Anonymous], US HISP POP SURP 45
   Aubin M, 2006, ONCOL NURS FORUM, V33, P1183, DOI 10.1188/06.ONF.1183-1188
   Bahn D, 2001, NURS EDUC TODAY, V21, P110, DOI 10.1054/nedt.2000.0522
   Bakitas M, 2009, JAMA-J AM MED ASSOC, V302, P741, DOI 10.1001/jama.2009.1198
   BANDURA A, 1977, PSYCHOL REV, V84, P191, DOI 10.1037/0033-295X.84.2.191
   Bowers Libby, 2003, Clin J Oncol Nurs, V7, P281, DOI 10.1188/03.CJON.281-288
   Breitbart W, 2010, PSYCHO-ONCOLOGY, V19, P21, DOI 10.1002/pon.1556
   Brown Jean K, 2002, Oncol Nurs Forum, V29, P517, DOI 10.1188/02.ONF.517-532
   Buck H.G., 2008, Journal of Hospice and Palliative Nursing, V10, P91, DOI DOI 10.1097/01.NJH.0000306737.08850.71
   Byock IR, 1996, CLIN GERIATR MED, V12, P237
   Campbell C.L., 2007, Journal of Hospice Palliative Nursing, V9, P31, DOI DOI 10.1097/00129191-2007
   Chambers SK, 2011, PATIENT EDUC COUNS, V85, pE75, DOI 10.1016/j.pec.2011.01.027
   Clapper T.C., 2010, CLIN SIMUL NURS, V6, pe7
   Devine E C, 1995, Oncol Nurs Forum, V22, P1369
   Devine Elizabeth C, 2003, Oncol Nurs Forum, V30, P75, DOI 10.1188/03.ONF.75-89
   Doorenbos A, 2006, NURS RES, V55, P161, DOI 10.1097/00006199-200605000-00002
   Flor H, 2004, PROG PAIN RES MANAG, V27, P47
   FOLKMAN S, 1980, J HEALTH SOC BEHAV, V21, P219, DOI 10.2307/2136617
   Frankl V.E., 1963, Mans search for meaning
   Gelman M, 1998, AUST NZ J PSYCHIAT, V32, P307
   Gibson CA, 2006, ANESTHESIOL CLIN N A, V24, P61, DOI 10.1016/j.atc.2005.12.001
   Given Barbara, 2009, Oncol Nurs Forum, V36, pE293, DOI 10.1188/09.ONF.E293-E302
   Glass E., 2007, Journal of Hospice and Palliative Nursing, V9, P15
   Goodwin PJ, 2001, NEW ENGL J MED, V345, P1719, DOI 10.1056/NEJMoa011871
   Henry M, 2010, PSYCHO-ONCOLOGY, V19, P1340, DOI 10.1002/pon.1764
   Kapo J, 2004, J PALLIAT MED S1, V8, pS148
   KARNOFSKY DA, 1948, CANCER-AM CANCER SOC, V1, P634, DOI 10.1002/1097-0142(194811)1:4<634::AID-CNCR2820010410>3.0.CO;2-L
   Keefe FJ, 2005, J PAIN SYMPTOM MANAG, V29, P263, DOI 10.1016/j.jpainsymman.2004.06.014
   Kolva E, 2011, J PAIN SYMPTOM MANAG, V42, P691, DOI 10.1016/j.jpainsymman.2011.01.013
   Kwekkeboom KL, 2010, ONCOL NURS FORUM, V37, P151
   Lauver DR, 2002, RES NURS HEALTH, V25, P246, DOI 10.1002/nur.10044
   Lavoy G, 1997, CALLINGS FINDING FOL
   Lepore SJ, 2006, ANN BEHAV MED, V32, P85, DOI 10.1207/s15324796abm3202_2
   Lloyd-Wiiams M, 2008, EUR J CANCER, V44, P1133, DOI 10.1016/j.ejca.2008.02.032
   Manne SL, 2006, ANN BEHAV MED, V32, P98, DOI 10.1207/s15324796abm3202_4
   McMillan SC, 2007, ONCOL NURS FORUM, V34, P313, DOI 10.1188/07.ONF.313-321
   Meyers FJ, 2011, J PALLIAT MED, V14, P465, DOI 10.1089/jpm.2010.0416
   Miller JJ, 2007, J PSYCHOSOC ONCOL, V25, P105, DOI 10.1300/J077v25n04_07
   Moorey S, 2009, PSYCHOL MED, V39, P713, DOI 10.1017/S0033291708004169
   National Hospice and Palliative Care Association, NHPCO FACTS FIG HOSP
   Peppercorn JM, 2011, J CLIN ONCOL, V29, P755, DOI 10.1200/JCO.2010.33.1744
   Porter LS, 2011, CURR PAIN HEADACHE R, V15, P263, DOI 10.1007/s11916-011-0190-6
   Ransom S, 2006, RES NURS HEALTH, V29, P190, DOI 10.1002/nur.20129
   Ropka M E, 2001, Oncol Nurs Forum, V28, P1585
   Savard Josee, 2006, Palliat Support Care, V4, P219
   Sherwood P, 2005, ONCOL NURS FORUM, V32, P1190, DOI 10.1188/05.ONF.1190-1198
   SKINNER BF, 1958, J EXP ANAL BEHAV, V1, P371, DOI 10.1901/jeab.1958.1-371
   Steel JL, 2007, J PSYCHOSOC ONCOL, V25, P19, DOI 10.1300/J077v25n03_02
   Teunissen SCCM, 2007, PALLIATIVE MED, V21, P341, DOI 10.1177/0269216307079067
   Thekkumpurath P, 2008, J PAIN SYMPTOM MANAG, V36, P520, DOI 10.1016/j.jpainsymman.2007.11.010
   Virnig BA, 2009, HEALTH AFFAIR, V28, P160, DOI 10.1377/hlthaff.28.1.160
   Waters SJ, 2004, PROG PAIN RES MANAG, V27, P261
   Weber BA, 2004, PSYCHO-ONCOLOGY, V13, P47, DOI 10.1002/pon.718
   Younis T, 2007, J PALLIAT MED, V10, P381, DOI 10.1089/jpm.2006.0071
NR 56
TC 28
Z9 33
U1 0
U2 48
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0738-3991
J9 PATIENT EDUC COUNS
JI Patient Educ. Couns.
PD OCT
PY 2012
VL 89
IS 1
BP 15
EP 24
DI 10.1016/j.pec.2012.06.019
PG 10
WC Public, Environmental & Occupational Health; Social Sciences,
   Interdisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Social Sciences - Other
   Topics
GA 028KJ
UT WOS:000310420900005
PM 22796302
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Shalom-Sharabi, I
   Samuels, N
   Lavie, O
   Lev, E
   Keinan-Boker, L
   Schiff, E
   Ben-Arye, E
AF Shalom-Sharabi, Ilanit
   Samuels, Noah
   Lavie, Ofer
   Lev, Efraim
   Keinan-Boker, Lital
   Schiff, Elad
   Ben-Arye, Eran
TI Effect of a patient-tailored integrative medicine program on
   gastro-intestinal concerns and quality of life in patients with breast
   and gynecologic cancer
SO JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
LA English
DT Article
DE Integrative medicine; Breast cancer; Complementary medicine;
   Chemotherapy; Quality of life; Supportive care
ID RANDOMIZED CONTROLLED-TRIAL; COMPLEMENTARY MEDICINE; INDUCED NAUSEA;
   ONCOLOGY; CHEMOTHERAPY; ACUPUNCTURE; OUTCOMES; ISRAEL; CARE; PREVENTION
AB This study was conducted to assess the impact of a patient-tailored complementary/integrative medicine (CIM) program on gastro-intestinal (GI) symptoms and other concerns in female patients with breast/gynecological cancer undergoing chemotherapy.
   Patients with breast/gynecological cancer reporting GI-related concerns were referred to an integrative physician (IP) consultation. The treatment group included patients agreeing to attend the consultation; controls those who did not. The Edmonton Symptom Assessment Scale (ESAS) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were administered at baseline and at 6 weeks. Adherence to integrative care (AIC) was defined as attending 4 CIM treatments, with 30 days between each session.
   Of 496 patients approached, 289 reported GI-related concerns. Optimal assessment at baseline and 6 weeks was achieved in 117 patients in the treatment arm, with 86 adhering to the CIM program (AIC subgroup); and in 89 of controls. EORTC scores improved more significantly in the treatment arm for appetite (P = 0.018), fatigue (P = 0.026), cognitive functioning (P < 0.001) and emotional functioning (P = 0.002); and ESAS scores for pain (P = 0.038), anxiety (P = 0.016), and sleep (P = 0.001). EORTC scores improved more significantly in the AIC group for global health status/QOL (P = 0.041), physical functioning (P = 0.004), role functioning (P = 0.011), appetite (P = 0.019), and fatigue (P = 0.001); and ESAS scores for pain (P = 0.048), fatigue (P = 0.011), drowsiness (P = 0.035), and appetite (P = 0.002).
   The integration of CIM may improve chemotherapy-related GI and other QOL-related concerns in patients with breast and gynecological cancer, with greater benefit observed in adherent patients.
C1 [Shalom-Sharabi, Ilanit; Samuels, Noah; Ben-Arye, Eran] Clalit Hlth Serv, Oncol Serv, Integrat Oncol Program, Haifa, Israel.
   [Shalom-Sharabi, Ilanit; Samuels, Noah; Ben-Arye, Eran] Clalit Hlth Serv, Lin Med Ctr, Haifa, Israel.
   [Samuels, Noah] Sheba Med Ctr, Inst Oncol, Tal Ctr Integrat Oncol, Tel Hashomer, Israel.
   [Lavie, Ofer] Carmel Hosp, Dept Obstet & Gynecol, Gynecol Oncol Serv, Haifa, Israel.
   [Lev, Efraim] Univ Haifa, Dept Eretz Israel Studies, Haifa, Israel.
   [Keinan-Boker, Lital] Univ Haifa, Sch Publ Hlth, Fac Social Welf & Hlth Sci, Haifa, Israel.
   [Keinan-Boker, Lital] Israel Minist Hlth, Israel Ctr Dis Control, Haifa, Israel.
   [Schiff, Elad] Bnai Zion Hosp, Dept Internal Med, Haifa, Israel.
   [Schiff, Elad] Bnai Zion Hosp, Integrat Med Serv, Haifa, Israel.
   [Ben-Arye, Eran] Technion Israel Inst Technol, Dept Family Med, Fac Med, Complementary & Tradit Med Unit, Haifa, Israel.
   [Ben-Arye, Eran] Clalit Hlth Serv, Haifa, Israel.
C3 Clalit Health Services; Clalit Health Services; Chaim Sheba Medical
   Center; Tel Aviv University; Clalit Health Services; Carmel Medical
   Center; University of Haifa; University of Haifa; Ministry of Health -
   Israel; Bnai Zion Medical Center; Bnai Zion Medical Center; Technion
   Israel Institute of Technology; Rappaport Faculty of Medicine; Clalit
   Health Services
RP Ben-Arye, E (corresponding author), Clalit Hlth Serv, Oncol Serv, Integrat Oncol Program, Haifa, Israel.; Ben-Arye, E (corresponding author), Clalit Hlth Serv, Lin Med Ctr, Haifa, Israel.; Ben-Arye, E (corresponding author), Technion Israel Inst Technol, Dept Family Med, Fac Med, Complementary & Tradit Med Unit, Haifa, Israel.; Ben-Arye, E (corresponding author), Clalit Hlth Serv, Haifa, Israel.
EM eranben@netvision.net.il
OI Lev, Efraim/0000-0002-9914-4164
CR AARONSON NK, 1993, J NATL CANCER I, V85, P365, DOI 10.1093/jnci/85.5.365
   Ben-Arye E, 2015, CLIN NUTR, V34, P1215, DOI 10.1016/j.clnu.2014.12.011
   Ben-Arye E, 2015, SUPPORT CARE CANCER, V23, P3411, DOI 10.1007/s00520-015-2690-0
   Ben-Arye E, 2015, J PAIN SYMPTOM MANAG, V49, P871, DOI 10.1016/j.jpainsymman.2014.09.014
   Ben-Arye E, 2013, MED ONCOL, V30, DOI 10.1007/s12032-013-0511-1
   Ben-Arye E, 2012, PATIENT EDUC COUNS, V89, P423, DOI 10.1016/j.pec.2012.02.011
   Bruera E, 1991, J Palliat Care, V7, P6
   Keshet Y, 2015, PSYCHO-ONCOLOGY, V24, P169, DOI 10.1002/pon.3621
   Lesi G, 2016, J CLIN ONCOL, V34, P1795, DOI 10.1200/JCO.2015.63.2893
   Minchom A, 2016, EUR J CANCER, V61, P102, DOI 10.1016/j.ejca.2016.03.078
   Molassiotis A, 2012, J CLIN ONCOL, V30, P4470, DOI 10.1200/JCO.2012.41.6222
   Oldenmenger WH, 2013, J PAIN SYMPTOM MANAG, V45, P1083, DOI 10.1016/j.jpainsymman.2012.06.007
   Palmer JB, 2015, J CLIN ONCOL, V33, P3162, DOI 10.1200/JCO.2014.59.6049
   Pedersen CG, 2009, EUR J CANCER, V45, P3172, DOI 10.1016/j.ejca.2009.09.005
   Rithirangsriroj K, 2015, GYNECOL ONCOL, V136, P82, DOI 10.1016/j.ygyno.2014.10.025
   Roila F, 2010, ANN ONCOL, V21, pv232, DOI 10.1093/annonc/mdq194
   Sawada NO, 2010, CANCER NURS, V33, pE21, DOI 10.1097/NCC.0b013e3181d86739
   Sharabi IS, 2016, SUPPORT CARE CANCER, V24, P4345, DOI 10.1007/s00520-016-3274-3
   Weeks LC, 2013, CURR ONCOL, V20, pE289, DOI 10.3747/co.20.1378
   Witt CM, 2015, BREAST CANCER RES TR, V149, P449, DOI 10.1007/s10549-014-3249-3
NR 20
TC 30
Z9 32
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0171-5216
EI 1432-1335
J9 J CANCER RES CLIN
JI J. Cancer Res. Clin. Oncol.
PD JUL
PY 2017
VL 143
IS 7
BP 1243
EP 1254
DI 10.1007/s00432-017-2368-8
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA EY8HQ
UT WOS:000404235900014
PM 28247032
OA Green Submitted
DA 2026-01-16
ER

EF